                         SEQUENCE LISTING

<110>  RAMOT AT TEL-AVIV UNIVERSITY LTD.
       DAMMES, Niels
       PEER, Dan
 
<120>  MAdCAM-1 POLYPEPTIDES AND USES THEREOF

<130>  86287

<150>  US 63/132,510
<151>  2020-12-31

<150>  US 63/026,793
<151>  2020-05-19

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
gaaaacctgt actttcaggg cgctgaaaca acagccccat ctgtc                       45


<210>  2
<211>  64
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
cctctagagt cgactggtac cgatatcaga tctatcgatg tcatttacca ggagagtggg       60

agag                                                                    64


<210>  3
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ctggtcgctg tgctcaaagg tgtccagtgt gactacaaag acgatgacga c                51


<210>  4
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
gatcgaaccc ttgtcgaggt cgggggatcc tcatttacca ggagagtggg                  50


<210>  5
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
gtgcactggc gtggtctggc caccagcttg ggcagtgtac                             40


<210>  6
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
gtacactgcc caagctggtg gccagaccac gccagtgcac                             40


<210>  7
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
gaaaacctgt actttcaggg cggttctggt gtgccaaggg aatgcaatcc ttgtggatgt       60


<210>  8
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
accagaacca cctagtactg gaatctcctt tctatgggtc agcaccag                    48


<210>  9
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IFNg siRNA Sense


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  is a DEOXYRIBONUCLEOTIDE INSTEAD OF A RIBONUCLEOTIDE

<400>  9
cauucaugag uauugccaag uuuga                                             25


<210>  10
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IFNg siRNA Anrisense


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (25)..(27)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<400>  10
ucaaacuugg caauacucau gaaugca                                           27


<210>  11
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine D1 domain

<400>  11

Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu Val Ala Val Ala Met 
1               5                   10                  15      


Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser Cys Asp Glu Gly Val 
            20                  25                  30          


Ala Arg Val His Trp Arg Gly Leu Asp Thr Ser Leu Gly Ser Val Gln 
        35                  40                  45              


Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg Gly Met Leu Ser Asp 
    50                  55                  60                  


Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly Ser Arg Ser Phe Gln 
65                  70                  75                  80  


His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro Asp Gln Leu 
                85                  90                  


<210>  12
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine D2 domain

<400>  12

Val Val Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln Val Val Ser 
1               5                   10                  15      


Cys Thr Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser Leu Ser Phe 
            20                  25                  30          


Ala Leu Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln Ala Leu Glu 
        35                  40                  45              


Pro Glu Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr Pro Leu Phe 
    50                  55                  60                  


Arg Met Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Leu His Cys Gln Val Thr Met Gln Leu Pro Lys Leu Val Leu 
                85                  90                  95      


Thr His Arg Lys Glu Ile Pro Val Leu 
            100                 105 


<210>  13
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc domain of rat IgG2a (including the hinge, excluding CH1)

<400>  13

Val Pro Arg Glu Cys Asn Pro Cys Gly Cys Thr Gly Ser Glu Val Ser 
1               5                   10                  15      


Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp Val Leu Thr Ile Thr 
            20                  25                  30          


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Gln Asn Asp 
        35                  40                  45              


Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp Val Glu Val His Thr 
    50                  55                  60                  


Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn Ser Thr Leu Arg Ser 
65                  70                  75                  80  


Val Ser Glu Leu Pro Ile Val His Arg Asp Trp Leu Asn Gly Lys Thr 
                85                  90                  95      


Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Ser Ile Ser Lys Pro Glu Gly Thr Pro Arg Gly Pro Gln Val Tyr Thr 
        115                 120                 125             


Met Ala Pro Pro Lys Glu Glu Met Thr Gln Ser Gln Val Ser Ile Thr 
    130                 135                 140                 


Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr Thr Glu Trp Lys 
145                 150                 155                 160 


Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr Pro Pro Thr Met 
                165                 170                 175     


Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Asn Val Lys Lys 
            180                 185                 190         


Glu Thr Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
        195                 200                 205             


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  14
<211>  1440
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA sequence of open reading frame of the D1D2-Fc construct.

<400>  14
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtgac       60

tacaaagacg atgacgacaa gcttgcggcc gcgcagtcct tccaggtgaa cccccctgag      120

tctgaggtag ctgtggccat gggcacatcc ctccagatca cctgcagcat gtcctgtgac      180

gagggtgtag cccgggtgca ctggcgtggt ctggacacca gcttgggcag tgtacagacc      240

ctcccaggca gcagtatcct ctctgtacgg ggcatgctgt cagacacagg cactcctgtg      300

tgtgtgggct cctgcgggag tcgaagcttc cagcactccg tgaagatcct tgtgtatgcc      360

ttcccagacc agctggtggt gtccccggag ttccttgtac ctggacagga ccaggtggtg      420

tcctgcacgg cccacaacat ctggcctgca gacccgaaca gtctctcctt tgccctgcta      480

ctgggagagc agagactgga gggtgcccaa gccctggaac cagagcaaga agaggagata      540

caagaggctg agggcacacc actgttccga atgacacaac gctggcggtt accctccctg      600

gggacccctg cccctcctgc ccttcactgc caggtcacca tgcagctgcc caaactggtg      660

ctgacccata gaaaggagat tccagtgctg ggcggaggcg ggagcggagg cggagggtcc      720

ggaggcggcg ggagcgtgcc aagggaatgc aatccttgtg gatgtacagg ctcagaagtg      780

tcatctgtct tcatcttccc cccaaagacc aaagatgtgc tcaccatcac tctgactcct      840

aaggtcacgt gtgttgtggt agacattagc cagaatgatc ccgaggtccg gttcagctgg      900

tttatagatg acgtggaagt ccacacagct cagactcatg ccccggagaa gcagtccaac      960

agcactttac gctcagtcag tgaactcccc atcgtgcacc gggactggct caatggcaag     1020

acgttcaaat gcaaagtcaa cagtggagca ttccctgccc ccatcgagaa aagcatctcc     1080

aaacccgaag gcacaccacg aggtccacag gtatacacca tggcgcctcc caaggaagag     1140

atgacccaga gtcaagtcag tatcacctgc atggtaaaag gcttctatcc cccagacatt     1200

tatacggagt ggaagatgaa cgggcagcca caggaaaact acaagaacac tccacctacg     1260

atggacacag atgggagtta cttcctctac agcaagctca atgtaaagaa agaaacatgg     1320

cagcagggaa acactttcac gtgttctgtg ctgcatgagg gcctgcacaa ccaccatact     1380

gagaagagtc tctcccactc tcctggtaaa ggctccggcc atcatcacca ccaccattga     1440


<210>  15
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein sequence of the D1D2-Fc construct.

<400>  15

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Tyr Lys Asp Asp Asp Asp Lys Leu Ala Ala Ala Gln 
            20                  25                  30          


Ser Phe Gln Val Asn Pro Pro Glu Ser Glu Val Ala Val Ala Met Gly 
        35                  40                  45              


Thr Ser Leu Gln Ile Thr Cys Ser Met Ser Cys Asp Glu Gly Val Ala 
    50                  55                  60                  


Arg Val His Trp Arg Gly Leu Asp Thr Ser Leu Gly Ser Val Gln Thr 
65                  70                  75                  80  


Leu Pro Gly Ser Ser Ile Leu Ser Val Arg Gly Met Leu Ser Asp Thr 
                85                  90                  95      


Gly Thr Pro Val Cys Val Gly Ser Cys Gly Ser Arg Ser Phe Gln His 
            100                 105                 110         


Ser Val Lys Ile Leu Val Tyr Ala Phe Pro Asp Gln Leu Val Val Ser 
        115                 120                 125             


Pro Glu Phe Leu Val Pro Gly Gln Asp Gln Val Val Ser Cys Thr Ala 
    130                 135                 140                 


His Asn Ile Trp Pro Ala Asp Pro Asn Ser Leu Ser Phe Ala Leu Leu 
145                 150                 155                 160 


Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln Ala Leu Glu Pro Glu Gln 
                165                 170                 175     


Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr Pro Leu Phe Arg Met Thr 
            180                 185                 190         


Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr Pro Ala Pro Pro Ala Leu 
        195                 200                 205             


His Cys Gln Val Thr Met Gln Leu Pro Lys Leu Val Leu Thr His Arg 
    210                 215                 220                 


Lys Glu Ile Pro Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Val Pro Arg Glu Cys Asn Pro Cys Gly Cys Thr 
                245                 250                 255     


Gly Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp 
            260                 265                 270         


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Ile Ser Gln Asn Asp Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Ser Val Ser Glu Leu Pro Ile Val His Arg Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Thr Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Ser Ile Ser Lys Pro Glu Gly Thr Pro Arg Gly 
        355                 360                 365             


Pro Gln Val Tyr Thr Met Ala Pro Pro Lys Glu Glu Met Thr Gln Ser 
    370                 375                 380                 


Gln Val Ser Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile 
385                 390                 395                 400 


Tyr Thr Glu Trp Lys Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Pro Pro Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Asn Val Lys Lys Glu Thr Trp Gln Gln Gly Asn Thr Phe Thr Cys 
        435                 440                 445             


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys Gly Ser Gly His His His His His His 
465                 470                 475                 


<210>  16
<211>  1440
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NA sequence of open reading frame of the mD1D2-Fc construct.

<400>  16
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtgac       60

tacaaagacg atgacgacaa gcttgcggcc gcgcagtcct tccaggtgaa cccccctgag      120

tctgaggtag ctgtggccat gggcacatcc ctccagatca cctgcagcat gtcctgtgac      180

gagggtgtag cccgggtgca ctggcgtggt ctggccacca gcttgggcag tgtacagacc      240

ctcccaggca gcagtatcct ctctgtacgg ggcatgctgt cagacacagg cactcctgtg      300

tgtgtgggct cctgcgggag tcgaagcttc cagcactccg tgaagatcct tgtgtatgcc      360

ttcccagacc agctggtggt gtccccggag ttccttgtac ctggacagga ccaggtggtg      420

tcctgcacgg cccacaacat ctggcctgca gacccgaaca gtctctcctt tgccctgcta      480

ctgggagagc agagactgga gggtgcccaa gccctggaac cagagcaaga agaggagata      540

caagaggctg agggcacacc actgttccga atgacacaac gctggcggtt accctccctg      600

gggacccctg cccctcctgc ccttcactgc caggtcacca tgcagctgcc caaactggtg      660

ctgacccata gaaaggagat tccagtgctg ggcggaggcg ggagcggagg cggagggtcc      720

ggaggcggcg ggagcgtgcc aagggaatgc aatccttgtg gatgtacagg ctcagaagtg      780

tcatctgtct tcatcttccc cccaaagacc aaagatgtgc tcaccatcac tctgactcct      840

aaggtcacgt gtgttgtggt agacattagc cagaatgatc ccgaggtccg gttcagctgg      900

tttatagatg acgtggaagt ccacacagct cagactcatg ccccggagaa gcagtccaac      960

agcactttac gctcagtcag tgaactcccc atcgtgcacc gggactggct caatggcaag     1020

acgttcaaat gcaaagtcaa cagtggagca ttccctgccc ccatcgagaa aagcatctcc     1080

aaacccgaag gcacaccacg aggtccacag gtatacacca tggcgcctcc caaggaagag     1140

atgacccaga gtcaagtcag tatcacctgc atggtaaaag gcttctatcc cccagacatt     1200

tatacggagt ggaagatgaa cgggcagcca caggaaaact acaagaacac tccacctacg     1260

atggacacag atgggagtta cttcctctac agcaagctca atgtaaagaa agaaacatgg     1320

cagcagggaa acactttcac gtgttctgtg ctgcatgagg gcctgcacaa ccaccatact     1380

gagaagagtc tctcccactc tcctggtaaa ggctccggcc atcatcacca ccaccattga     1440


<210>  17
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein sequence of the mD1D2-Fc construct.

<400>  17

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Tyr Lys Asp Asp Asp Asp Lys Leu Ala Ala Ala Gln 
            20                  25                  30          


Ser Phe Gln Val Asn Pro Pro Glu Ser Glu Val Ala Val Ala Met Gly 
        35                  40                  45              


Thr Ser Leu Gln Ile Thr Cys Ser Met Ser Cys Asp Glu Gly Val Ala 
    50                  55                  60                  


Arg Val His Trp Arg Gly Leu Ala Thr Ser Leu Gly Ser Val Gln Thr 
65                  70                  75                  80  


Leu Pro Gly Ser Ser Ile Leu Ser Val Arg Gly Met Leu Ser Asp Thr 
                85                  90                  95      


Gly Thr Pro Val Cys Val Gly Ser Cys Gly Ser Arg Ser Phe Gln His 
            100                 105                 110         


Ser Val Lys Ile Leu Val Tyr Ala Phe Pro Asp Gln Leu Val Val Ser 
        115                 120                 125             


Pro Glu Phe Leu Val Pro Gly Gln Asp Gln Val Val Ser Cys Thr Ala 
    130                 135                 140                 


His Asn Ile Trp Pro Ala Asp Pro Asn Ser Leu Ser Phe Ala Leu Leu 
145                 150                 155                 160 


Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln Ala Leu Glu Pro Glu Gln 
                165                 170                 175     


Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr Pro Leu Phe Arg Met Thr 
            180                 185                 190         


Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr Pro Ala Pro Pro Ala Leu 
        195                 200                 205             


His Cys Gln Val Thr Met Gln Leu Pro Lys Leu Val Leu Thr His Arg 
    210                 215                 220                 


Lys Glu Ile Pro Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Val Pro Arg Glu Cys Asn Pro Cys Gly Cys Thr 
                245                 250                 255     


Gly Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Thr Lys Asp 
            260                 265                 270         


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Ile Ser Gln Asn Asp Pro Glu Val Arg Phe Ser Trp Phe Ile Asp Asp 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr His Ala Pro Glu Lys Gln Ser Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Ser Val Ser Glu Leu Pro Ile Val His Arg Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Thr Phe Lys Cys Lys Val Asn Ser Gly Ala Phe Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Ser Ile Ser Lys Pro Glu Gly Thr Pro Arg Gly 
        355                 360                 365             


Pro Gln Val Tyr Thr Met Ala Pro Pro Lys Glu Glu Met Thr Gln Ser 
    370                 375                 380                 


Gln Val Ser Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile 
385                 390                 395                 400 


Tyr Thr Glu Trp Lys Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Pro Pro Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Asn Val Lys Lys Glu Thr Trp Gln Gln Gly Asn Thr Phe Thr Cys 
        435                 440                 445             


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
    450                 455                 460                 


Ser His Ser Pro Gly Lys Gly Ser Gly His His His His His His 
465                 470                 475                 


<210>  18
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Negative Control siRNA sense


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  IS A DEOXYRIBONUCLEOTIDE INSTEAD OF A RIBONUCLEOTIDE

<400>  18
cauauugcgc guauagucgc guuag                                             25


<210>  19
<211>  27
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Negative Control siRNA antisense


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (25)..(27)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<400>  19
cuaacgcgac uauacgcgca auauggu                                           27


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA CD45 Sense


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (10)..(13)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ARE DEOXYRIBONUCLEOTIDES

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ARE  LINKED TOGETHER WITH A PHOSPHOROTHIOATE BOND

<400>  20
cuggcugaau uucagagcat t                                                 21


<210>  21
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  4 aa MAdCAM-1 D1 binding sequence

<400>  21

Leu Asp Thr Ser 
1               


<210>  22
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAdCAM01 D1D2 sequence

<400>  22

Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu Val Ala Val Ala Met 
1               5                   10                  15      


Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser Cys Asp Glu Gly Val 
            20                  25                  30          


Ala Arg Val His Trp Arg Gly Leu Asp Thr Ser Leu Gly Ser Val Gln 
        35                  40                  45              


Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg Gly Met Leu Ser Asp 
    50                  55                  60                  


Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly Ser Arg Ser Phe Gln 
65                  70                  75                  80  


His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro Asp Gln Leu Val Val 
                85                  90                  95      


Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln Val Val Ser Cys Thr 
            100                 105                 110         


Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser Leu Ser Phe Ala Leu 
        115                 120                 125             


Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln Ala Leu Glu Pro Glu 
    130                 135                 140                 


Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr Pro Leu Phe Arg Met 
145                 150                 155                 160 


Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr Pro Ala Pro Pro Ala 
                165                 170                 175     


Leu His Cys Gln Val Thr Met Gln Leu Pro Lys Leu Val Leu Thr His 
            180                 185                 190         


Arg Lys Glu Ile Pro Val Leu 
        195                 


<210>  23
<211>  405
<212>  PRT
<213>  Mus musculus

<400>  23

Met Glu Ser Ile Leu Ser Leu Leu Leu Ser Leu Ser Leu Val Pro Tyr 
1               5                   10                  15      


Gln Leu Ser Arg Gly Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu 
            20                  25                  30          


Val Ala Val Ala Met Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser 
        35                  40                  45              


Cys Asp Glu Gly Val Ala Arg Val His Trp Arg Gly Arg Asp Thr Ser 
    50                  55                  60                  


Leu Gly Ser Val Gln Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg 
65                  70                  75                  80  


Gly Met Leu Ser Asp Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly 
                85                  90                  95      


Ser Arg Ser Phe Gln His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro 
            100                 105                 110         


Asp Gln Leu Val Val Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln 
        115                 120                 125             


Val Val Ser Cys Thr Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser 
    130                 135                 140                 


Leu Ser Phe Ala Leu Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln 
145                 150                 155                 160 


Ala Leu Glu Pro Glu Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr 
                165                 170                 175     


Pro Leu Phe Arg Met Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr 
            180                 185                 190         


Pro Ala Pro Pro Ala Leu His Cys Gln Val Thr Met Gln Leu Pro Lys 
        195                 200                 205             


Leu Val Leu Thr His Arg Lys Glu Ile Pro Val Leu Gln Ser Gln Thr 
    210                 215                 220                 


Ser Pro Lys Pro Pro Asn Thr Thr Ser Ala Glu Pro Tyr Ile Leu Thr 
225                 230                 235                 240 


Ser Ser Ser Thr Ala Glu Ala Val Ser Thr Gly Leu Asn Ile Thr Thr 
                245                 250                 255     


Leu Pro Ser Ala Pro Pro Tyr Pro Lys Leu Ser Pro Arg Thr Leu Ser 
            260                 265                 270         


Ser Glu Gly Pro Cys Arg Pro Lys Ile His Gln Asp Leu Glu Ala Gly 
        275                 280                 285             


Trp Glu Leu Leu Cys Glu Ala Ser Cys Gly Pro Gly Val Thr Val Arg 
    290                 295                 300                 


Trp Thr Leu Ala Pro Gly Asp Leu Ala Thr Tyr His Lys Arg Glu Ala 
305                 310                 315                 320 


Gly Ala Gln Ala Trp Leu Ser Val Leu Pro Pro Gly Pro Met Val Glu 
                325                 330                 335     


Gly Trp Phe Gln Cys Arg Gln Asp Pro Gly Gly Glu Val Thr Asn Leu 
            340                 345                 350         


Tyr Val Pro Gly Gln Val Thr Pro Asn Ser Ser Ser Thr Val Val Leu 
        355                 360                 365             


Trp Ile Gly Ser Leu Val Leu Gly Leu Leu Ala Leu Val Phe Leu Ala 
    370                 375                 380                 


Tyr Arg Leu Trp Lys Cys Tyr Arg Pro Gly Pro Arg Pro Asp Thr Ser 
385                 390                 395                 400 


Ser Cys Thr His Leu 
                405 


<210>  24
<211>  261
<212>  PRT
<213>  Mus musculus

<400>  24

Met Glu Ser Ile Leu Ala Leu Leu Leu Ala Leu Ala Leu Val Pro Tyr 
1               5                   10                  15      


Gln Leu Ser Arg Gly Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu 
            20                  25                  30          


Val Ala Val Ala Met Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser 
        35                  40                  45              


Cys Asp Glu Gly Val Ala Arg Val His Trp Arg Gly Leu Asp Thr Ser 
    50                  55                  60                  


Leu Gly Ser Val Gln Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg 
65                  70                  75                  80  


Gly Met Leu Ser Asp Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly 
                85                  90                  95      


Ser Arg Ser Phe Gln His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro 
            100                 105                 110         


Asp Gln Leu Val Val Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln 
        115                 120                 125             


Val Val Ser Cys Thr Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser 
    130                 135                 140                 


Leu Ser Phe Ala Leu Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln 
145                 150                 155                 160 


Ala Leu Glu Pro Glu Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr 
                165                 170                 175     


Pro Leu Phe Arg Met Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr 
            180                 185                 190         


Pro Ala Pro Pro Ala Leu His Cys Gln Val Thr Met Gln Leu Pro Lys 
        195                 200                 205             


Leu Val Leu Thr His Arg Lys Glu Ile Pro Ala Ser Thr Val Val Leu 
    210                 215                 220                 


Trp Ile Gly Ser Leu Val Leu Gly Leu Leu Ala Leu Val Phe Leu Ala 
225                 230                 235                 240 


Tyr Arg Leu Trp Lys Cys Tyr Arg Pro Gly Pro Arg Pro Asp Thr Ser 
                245                 250                 255     


Ser Cys Thr His Leu 
            260     


<210>  25
<211>  405
<212>  PRT
<213>  Mus musculus

<400>  25

Met Glu Ser Ile Leu Ala Leu Leu Leu Ala Leu Ala Leu Val Pro Tyr 
1               5                   10                  15      


Gln Leu Ser Arg Gly Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu 
            20                  25                  30          


Val Ala Val Ala Met Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser 
        35                  40                  45              


Cys Asp Glu Gly Val Ala Arg Val His Trp Arg Gly Leu Asp Thr Ser 
    50                  55                  60                  


Leu Gly Ser Val Gln Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg 
65                  70                  75                  80  


Gly Met Leu Ser Asp Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly 
                85                  90                  95      


Ser Arg Ser Phe Gln His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro 
            100                 105                 110         


Asp Gln Leu Val Val Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln 
        115                 120                 125             


Val Val Ser Cys Thr Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser 
    130                 135                 140                 


Leu Ser Phe Ala Leu Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln 
145                 150                 155                 160 


Ala Leu Glu Pro Glu Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr 
                165                 170                 175     


Pro Leu Phe Arg Met Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr 
            180                 185                 190         


Pro Ala Pro Pro Ala Leu His Cys Gln Val Thr Met Gln Leu Pro Lys 
        195                 200                 205             


Leu Val Leu Thr His Arg Lys Glu Ile Pro Val Leu Gln Ser Gln Thr 
    210                 215                 220                 


Ser Pro Lys Pro Pro Asn Thr Thr Ser Ala Glu Pro Tyr Ile Leu Thr 
225                 230                 235                 240 


Ser Ser Ser Thr Ala Glu Ala Val Ser Thr Gly Leu Asn Ile Thr Thr 
                245                 250                 255     


Leu Pro Ser Ala Pro Pro Tyr Pro Lys Leu Ser Pro Arg Thr Leu Ser 
            260                 265                 270         


Ser Glu Gly Pro Cys Arg Pro Lys Ile His Gln Asp Leu Glu Ala Gly 
        275                 280                 285             


Trp Glu Leu Leu Cys Glu Ala Ser Cys Gly Pro Gly Val Thr Val Arg 
    290                 295                 300                 


Trp Thr Leu Ala Pro Gly Asp Leu Ala Thr Tyr His Lys Arg Glu Ala 
305                 310                 315                 320 


Gly Ala Gln Ala Trp Leu Ser Val Leu Pro Pro Gly Pro Met Val Glu 
                325                 330                 335     


Gly Trp Phe Gln Cys Arg Gln Asp Pro Gly Gly Gln Val Thr Asn Leu 
            340                 345                 350         


Tyr Val Pro Gly Gln Val Thr Pro Asn Ser Ser Ser Thr Val Val Leu 
        355                 360                 365             


Trp Ile Gly Ser Leu Val Leu Gly Leu Leu Ala Leu Val Phe Leu Ala 
    370                 375                 380                 


Tyr Arg Leu Trp Lys Cys Tyr Arg Pro Gly Pro Arg Pro Asp Thr Ser 
385                 390                 395                 400 


Ser Cys Thr His Leu 
                405 


<210>  26
<211>  382
<212>  PRT
<213>  homo sapiens

<400>  26

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu 
    210                 215                 220                 


His Ser Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser 
225                 230                 235                 240 


Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro 
                245                 250                 255     


Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro 
            260                 265                 270         


Ala Pro Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr 
        275                 280                 285             


Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu 
    290                 295                 300                 


Val Ile Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala 
305                 310                 315                 320 


Ala Leu Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu 
                325                 330                 335     


Pro Thr Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp 
            340                 345                 350         


Thr His Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp 
        355                 360                 365             


Ala Gly Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
    370                 375                 380         


<210>  27
<211>  295
<212>  PRT
<213>  homo sapiens

<400>  27

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Ala Ser 
    210                 215                 220                 


Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu Trp Thr Ser Ser Ala 
225                 230                 235                 240 


Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr Tyr His Leu Trp Lys 
                245                 250                 255     


Arg Cys Arg His Leu Ala Glu Asp Asp Thr His Pro Pro Ala Ser Leu 
            260                 265                 270         


Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly Leu Arg Gly Thr Gly 
        275                 280                 285             


Gln Val Gly Ile Ser Pro Ser 
    290                 295 


<210>  28
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extracellular domain of Mouse MAdCAM-1

<400>  28

Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu Val Ala Val Ala Met 
1               5                   10                  15      


Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser Cys Asp Glu Gly Val 
            20                  25                  30          


Ala Arg Val His Trp Arg Gly Leu Asp Thr Ser Leu Gly Ser Val Gln 
        35                  40                  45              


Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg Gly Met Leu Ser Asp 
    50                  55                  60                  


Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly Ser Arg Ser Phe Gln 
65                  70                  75                  80  


His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro Asp Gln Leu Val Val 
                85                  90                  95      


Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln Val Val Ser Cys Thr 
            100                 105                 110         


Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser Leu Ser Phe Ala Leu 
        115                 120                 125             


Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln Ala Leu Glu Pro Glu 
    130                 135                 140                 


Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr Pro Leu Phe Arg Met 
145                 150                 155                 160 


Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr Pro Ala Pro Pro Ala 
                165                 170                 175     


Leu His Cys Gln Val Thr Met Gln Leu Pro Lys Leu Val Leu Thr His 
            180                 185                 190         


Arg Lys Glu Ile Pro Val Leu Gln Ser Gln Thr Ser Pro Lys Pro Pro 
        195                 200                 205             


Asn Thr Thr Ser Ala Glu Pro Tyr Ile Leu Thr Ser Ser Ser Thr Ala 
    210                 215                 220                 


Glu Ala Val Ser Thr Gly Leu Asn Ile Thr Thr Leu Pro Ser Ala Pro 
225                 230                 235                 240 


Pro Tyr Pro Lys Leu Ser Pro Arg Thr Leu Ser Ser Glu Gly Pro Cys 
                245                 250                 255     


Arg Pro Lys Ile His Gln Asp Leu Glu Ala Gly Trp Glu Leu Leu Cys 
            260                 265                 270         


Glu Ala Ser Cys Gly Pro Gly Val Thr Val Arg Trp Thr Leu Ala Pro 
        275                 280                 285             


Gly Asp Leu Ala Thr Tyr His Lys Arg Glu Ala Gly Ala Gln Ala Trp 
    290                 295                 300                 


Leu Ser Val Leu Pro Pro Gly Pro Met Val Glu Gly Trp Phe Gln Cys 
305                 310                 315                 320 


Arg Gln Asp Pro Gly Gly Gln Val Thr Asn Leu Tyr Val Pro Gly Gln 
                325                 330                 335     


Val Thr Pro Asn Ser Ser Ser Thr 
            340                 


<210>  29
<211>  321
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Extracellular domain of HUman MAdCAM-1

<400>  29

Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val Val Ala Val Ala 
1               5                   10                  15      


Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala Cys Ala Asp Arg 
            20                  25                  30          


Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser Leu Gly Ala Val 
        35                  40                  45              


Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg Asn Ala Ser Leu 
    50                  55                  60                  


Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys Gly Gly Arg Thr 
65                  70                  75                  80  


Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe Pro Asp Gln Leu 
                85                  90                  95      


Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro Glu Val Ala Cys 
            100                 105                 110         


Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala Leu Ser Phe Ser 
        115                 120                 125             


Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln Ala Leu Gly Pro 
    130                 135                 140                 


Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp Glu Asp Val Leu 
145                 150                 155                 160 


Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu Gly Thr Pro Val 
                165                 170                 175     


Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu Pro Gly Leu Glu 
            180                 185                 190         


Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser Pro Thr Ser Pro 
        195                 200                 205             


Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro Asn Thr Thr Ser Pro 
    210                 215                 220                 


Glu Ser Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln 
225                 230                 235                 240 


Glu Pro Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Gln 
                245                 250                 255     


Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro 
            260                 265                 270         


Glu Pro Ala Pro Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly 
        275                 280                 285             


Ser Thr Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln 
    290                 295                 300                 


Gly Glu Val Ile Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu 
305                 310                 315                 320 


Pro 
    


<210>  30
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Transmembrane domain of Mouse MAdCAM-1

<400>  30

Val Val Leu Trp Ile Gly Ser Leu Val Leu Gly Leu Leu Ala Leu Val 
1               5                   10                  15      


Phe Leu Ala Tyr 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Transmembrane domain of Human MAdCAM-1

<400>  31

Ala Ala Leu Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Leu Pro Thr Tyr 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Intracellular domain of Mouse MAdCAM-1

<400>  32

Arg Leu Trp Lys Cys Tyr Arg Pro Gly Pro Arg Pro Asp Thr Ser Ser 
1               5                   10                  15      


Cys Thr His Leu 
            20  


<210>  33
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Intracellular domain of Human MAdCAM-1

<400>  33

His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp Thr His Pro 
1               5                   10                  15      


Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly Leu 
            20                  25                  30          


Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
        35                  40              


<210>  34
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D1 domain of mouse MAdCAM-1

<400>  34

Gln Ser Phe Gln Val Asn Pro Pro Glu Ser Glu Val Ala Val Ala Met 
1               5                   10                  15      


Gly Thr Ser Leu Gln Ile Thr Cys Ser Met Ser Cys Asp Glu Gly Val 
            20                  25                  30          


Ala Arg Val His Trp Arg Gly Leu Asp Thr Ser Leu Gly Ser Val Gln 
        35                  40                  45              


Thr Leu Pro Gly Ser Ser Ile Leu Ser Val Arg Gly Met Leu Ser Asp 
    50                  55                  60                  


Thr Gly Thr Pro Val Cys Val Gly Ser Cys Gly Ser Arg Ser Phe Gln 
65                  70                  75                  80  


His Ser Val Lys Ile Leu Val Tyr Ala Phe Pro Asp Gln Leu 
                85                  90                  


<210>  35
<211>  90
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D1 domain of HUMAN MAdCAM-1

<400>  35

Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val Val Ala Val Ala 
1               5                   10                  15      


Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala Cys Ala Asp Arg 
            20                  25                  30          


Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser Leu Gly Ala Val 
        35                  40                  45              


Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg Asn Ala Ser Leu 
    50                  55                  60                  


Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys Gly Gly Arg Thr 
65                  70                  75                  80  


Phe Gln His Thr Val Gln Leu Leu Val Tyr 
                85                  90  


<210>  36
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D2 domain of mouse MAdCAM-1

<400>  36

Val Val Ser Pro Glu Phe Leu Val Pro Gly Gln Asp Gln Val Val Ser 
1               5                   10                  15      


Cys Thr Ala His Asn Ile Trp Pro Ala Asp Pro Asn Ser Leu Ser Phe 
            20                  25                  30          


Ala Leu Leu Leu Gly Glu Gln Arg Leu Glu Gly Ala Gln Ala Leu Glu 
        35                  40                  45              


Pro Glu Gln Glu Glu Glu Ile Gln Glu Ala Glu Gly Thr Pro Leu Phe 
    50                  55                  60                  


Arg Met Thr Gln Arg Trp Arg Leu Pro Ser Leu Gly Thr Pro Ala Pro 
65                  70                  75                  80  


Pro Ala Leu His Cys Gln Val Thr Met Gln Leu Pro Lys Leu Val Leu 
                85                  90                  95      


Thr His Arg Lys Glu Ile Pro Val Leu 
            100                 105 


<210>  37
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D2 domain of HUMAN MAdCAM-1

<400>  37

Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
1               5                   10                  15      


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
            20                  25                  30          


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
        35                  40                  45              


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
    50                  55                  60                  


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
65                  70                  75                  80  


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
                85                  90                  95      


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu 
            100                 105                 110         


His 
    


<210>  38
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mouse D3 domain

<400>  38

Pro Ser Ala Pro Pro Tyr Pro Lys Leu Ser Pro Arg Thr Leu Ser Ser 
1               5                   10                  15      


Glu Gly Pro Cys Arg Pro Lys Ile His Gln Asp Leu Glu Ala Gly Trp 
            20                  25                  30          


Glu Leu Leu Cys Glu Ala Ser Cys Gly Pro Gly Val Thr Val Arg Trp 
        35                  40                  45              


Thr Leu Ala Pro Gly Asp Leu Ala Thr Tyr His Lys Arg Glu Ala Gly 
    50                  55                  60                  


Ala Gln Ala Trp Leu Ser Val Leu Pro Pro Gly Pro Met Val Glu Gly 
65                  70                  75                  80  


Trp Phe Gln Cys Arg Gln Asp Pro Gly Gly Gln Val Thr Asn Leu Tyr 
                85                  90                  95      


Val Pro Gly Gln Val Thr Pro Asn Ser Ser Ser Thr 
            100                 105             


<210>  39
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mucin-like domain of mouse MAdCAM-1

<400>  39

Gln Ser Gln Thr Ser Pro Lys Pro Pro Asn Thr Thr Ser Ala Glu Pro 
1               5                   10                  15      


Tyr Ile Leu Thr Ser Ser Ser Thr Ala Glu Ala Val Ser Thr Gly Leu 
            20                  25                  30          


Asn Ile Thr Thr Leu 
        35          


<210>  40
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mucin-like domain of HUMAN MAdCAM-1

<400>  40

Ser Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro 
1               5                   10                  15      


Asn Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Pro Glu Ser Pro 
            20                  25                  30          


Asp Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Gln Glu Pro Pro 
        35                  40                  45              


Asp Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro 
    50                  55                  60                  


Asp Lys Thr Ser Pro Glu Pro Ala Pro Gln Gln Gly Ser Thr His Thr 
65                  70                  75                  80  


Pro Arg Ser Pro Gly Ser Thr Arg Thr Arg Arg Pro Glu Ile Ser Gln 
                85                  90                  95      


Ala Gly Pro Thr Gln Gly Glu Val Ile Pro Thr Gly Ser Ser Lys Pro 
            100                 105                 110         


Ala Gly Asp Gln Leu Pro 
        115             


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA CD45 antisense


<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-METHYL RIBONUCLEOTIDE

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ARE DEOXYRIBONUCLEOTIDES INSTEAD OF A RIBONUCLEOTIDES

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  INKED TOGETHER WITH A PHOSPHOROTHIOATE BOND

<400>  41
ugcucugaaa uucagccagt t                                                 21


