                         SEQUENCE LISTING

<110>  Yale University
       Simons, Michael
       Corti, Federico
 
<120>  Methods and Compositions to Treat Vascular Leak

<130>  047162-7286WO1(01355)

<150>  U.S. Provisional Patent Application No: 63/029,062
<151>  2020-05-22

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526A8-Heavy Chain Variable Region

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asp 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Gly Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526A8- Light Chain Variable Region

<400>  2

Ser Ser Glu Leu Thr Gln Pro Ser Ser Val Ser Met Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 
            20                  25                  30          


Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Arg 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  3
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526B9-Heavy Chain Variable Region

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Gly Ile Arg Ala Tyr Gly Gly Tyr Ser Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526B9-Light Chain Variable Region

<400>  4

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Asn Ser Gly Ser Val Ser Ser Arg 
            20                  25                  30          


Phe Phe Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Arg Ile Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Phe Ile Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Val Tyr Tyr Cys Leu Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526E1-Heavy Chain Variable Region

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Ile Arg Gly Gln Arg Tyr Phe Ala Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526E1-Light Chain Variable Region

<400>  6

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526F3-Heavy Chain Variable Region

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Gly Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526F3-Light Chain Variable Region

<400>  8

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Leu Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Tyr Tyr Tyr Cys Leu Leu Tyr Met Gly Arg 
                85                  90                  95      


Gly Val Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526H5-Heavy Chain Variable Region

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Arg Gly Tyr Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526H5-Light Chain Variable Region

<400>  10

Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 
            20                  25                  30          


Arg Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Lys Gly Phe 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105     


<210>  11
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526A8-Heavy Chain

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asp 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Gly Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  12
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526A8- Light Chain

<400>  12

Ser Ser Glu Leu Thr Gln Pro Ser Ser Val Ser Met Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 
            20                  25                  30          


Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Arg 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  13
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526B9-Heavy Chain

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Gly Ile Arg Ala Tyr Gly Gly Tyr Ser Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  14
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526B9-Light Chain

<400>  14

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Asn Ser Gly Ser Val Ser Ser Arg 
            20                  25                  30          


Phe Phe Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Pro Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Arg Ile Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Phe Ile Leu Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Val Tyr Tyr Cys Leu Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  15
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526E1-Heavy Chain

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Ile Arg Gly Gln Arg Tyr Phe Ala Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  16
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526E1-Light Chain

<400>  16

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  17
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526F3-Heavy Chain

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Gly Gly Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  18
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526F3-Light Chain

<400>  18

Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Thr 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Leu Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Tyr Tyr Tyr Cys Leu Leu Tyr Met Gly Arg 
                85                  90                  95      


Gly Val Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  19
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526H5-Heavy Chain

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Arg Gly Tyr Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  20
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526H5-Light Chain

<400>  20

Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 
            20                  25                  30          


Arg Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Lys Gly Phe 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Val Thr Val Leu Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  21
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526A8-Heavy Chain- with tag

<400>  21

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Asp Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Asn Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Tyr Gly Asp Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  22
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526A8- Light Chain- with tag

<400>  22

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Ser Glu Leu Thr Gln Pro Ser Ser Val Ser Met 
            20                  25                  30          


Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala 
        35                  40                  45              


Lys Lys Tyr Ala Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  


Leu Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly 
                85                  90                  95      


Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser 
            100                 105                 110         


Ser Gly Thr Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  23
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526B9-Heavy Chain- with tag

<400>  23

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Pro Arg Gly Ile Arg Ala Tyr Gly Gly Tyr Ser 
        115                 120                 125             


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  24
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526B9-Light Chain- with tag

<400>  24

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val 
            20                  25                  30          


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Asn Ser Gly Ser 
        35                  40                  45              


Val Ser Ser Arg Phe Phe Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln 
    50                  55                  60                  


Pro Pro Arg Thr Leu Ile Tyr Ser Thr Arg Ile Arg Ser Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Phe Ile Leu Gly Asp Lys Ala Ala Leu Thr 
                85                  90                  95      


Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Val Tyr Tyr Cys Leu Leu 
            100                 105                 110         


Tyr Met Gly Ser Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  25
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526E1-Heavy Chain- with tag

<400>  25

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys His Ile Arg Gly Gln Arg Tyr Phe Ala Tyr Met 
        115                 120                 125             


Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  26
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526E1-Light Chain- with tag

<400>  26

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Val Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Ser Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
            100                 105                 110         


Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  27
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526F3-Heavy Chain- with tag

<400>  27

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Arg Arg Gly Gly Gly Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  28
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526F3-Light Chain- with tag

<400>  28

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Gln Ala Val Val Thr Gln Glu Pro Ser Phe Ser Val 
            20                  25                  30          


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser 
        35                  40                  45              


Val Ser Thr Thr Tyr Tyr Pro Ser Trp Tyr Gln Leu Thr Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Thr Leu Ile Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr 
                85                  90                  95      


Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Tyr Tyr Tyr Cys Leu Leu 
            100                 105                 110         


Tyr Met Gly Arg Gly Val Arg Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  29
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526H5-Heavy Chain- with tag

<400>  29

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Gly Leu Arg Gly Tyr Ala Phe Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  30
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11526H5-Light Chain- with tag

<400>  30

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Tyr Val Leu Thr Gln Pro Ser Ser Val Ser Val 
            20                  25                  30          


Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala 
        35                  40                  45              


Lys Lys Tyr Ala Arg Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Val 
    50                  55                  60                  


Leu Leu Ile Tyr Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Gly 
                85                  90                  95      


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp 
            100                 105                 110         


Asn Lys Gly Phe Phe Gly Thr Gly Thr Lys Val Thr Val Leu Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syndecan-2 disrupting peptide human

<400>  31

Pro Ala Glu Glu Asp Thr Asn Val Tyr Thr Glu Lys His Ser Asp Ser 
1               5                   10                  15      


Leu Phe 
        


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syndecan-2 disrupting peptide mouse

<400>  32

Pro Ala Ile Lys Ser Thr Asp Val Tyr Thr Glu Lys His Ser Asp Asn 
1               5                   10                  15      


Leu Phe 
        


<210>  33
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SDC2 extracellular

<400>  33

Met Tyr Leu Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro 
1               5                   10                  15      


Ile Asp Asp Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu 
            20                  25                  30          


Asp Val Glu Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile 
        35                  40                  45              


Leu Leu Thr Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile 
    50                  55                  60                  


Gln Asn Lys Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys 
65                  70                  75                  80  


Glu Lys Val His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu 
                85                  90                  95      


Glu Asp Thr Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys 
            100                 105                 110         


Arg Thr Glu Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe 
        115                 120                 125             


Leu Phe Ala Ile Phe Leu Ile Leu Leu 
    130                 135         


<210>  34
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SDC2 Human

<400>  34

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210>  35
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SDC2 Mouse

<400>  35

Met Gln Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Met Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Thr Arg Thr Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ser Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Ile Glu 
    50                  55                  60                  


Ser Pro Val Leu Thr Thr Ser Gln Leu Ile Pro Arg Ile Pro Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Ser Pro Lys Val Glu Thr Met Thr Leu Lys Thr Gln Ser 
                85                  90                  95      


Ile Thr Pro Ala Gln Thr Glu Ser Pro Glu Glu Thr Asp Lys Glu Glu 
            100                 105                 110         


Val Asp Ile Ser Glu Ala Glu Glu Lys Leu Gly Pro Ala Ile Lys Ser 
        115                 120                 125             


Thr Asp Val Tyr Thr Glu Lys His Ser Asp Asn Leu Phe Lys Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe 
145                 150                 155                 160 


Ala Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr 
            180                 185                 190         


Gln Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200         


<210>  36
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Syndecan 2 IgG heavy chain constant region

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  37
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Syndecan 2 IgG light chain constant region

<400>  37

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Syndecan 2 heavy chain tag

<400>  38

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu 
        


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Syndecan 2 light chain tag

<400>  39

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr 
            


<210>  40
<211>  1427
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256A8-HC cDNA

<400>  40
gaattcgccg ccaccatgaa gcacctgtgg ttcttcctgc tgctggtggc cgccccccgg       60

tgggtgctgt ccgaggtgca gctggtgcag tccggcggcg gagtggtgca gcctggaagg      120

agcctgaggc tgtcctgcgc tgcttctggc ttcaccttca gccgggacgg catgcactgg      180

gtgaggcagg cccccggaaa gggcctggag tgggtggctg tgatctggaa tgacggctcc      240

aacaagtact acgccgattc cgtgaagggc cggttcacca tcagccggga caattccaag      300

aataccctgt acctgcagat gaatagcctg cgggccgagg ataccgctgt gtattactgt      360

gctcggcact atggcgacta cggcatggac gtgtggggcc agggcaccac cgtgaccgtg      420

agctccgcta gcaccaaggg accttctgtg ttccctctgg ctccttcttc taagtccact      480

tccggtggta cagcagctct gggttgtctg gtgaaggatt acttcccaga accagtgact      540

gtgtcctgga actccggagc tctgacttct ggagtgcata ctttcccagc agtgctgcaa      600

tctagcggac tgtactctct gtcttccgtg gtgactgtgc cttcttcttc cctggggact      660

caaacttaca tctgcaacgt gaaccacaag ccctccaaca ccaaggtgga caagaaggtg      720

gagccaaaga gctgcgataa gacccacacc tgtccacctt gtccagctcc agaactgctg      780

ggtgggcctt ctgtgtttct gttcccacct aagccaaagg ataccctgat gatctctagg      840

accccagaag tgacctgtgt ggtcgtcgat gtgtctcatg aagaccctga agtgaagttc      900

aactggtacg tggacggggt ggaagtgcat aacgcaaaga ccaagcccag ggaagagcaa      960

tacaactcca cctacagggt ggtctccgtc ctgacagtcc tgcatcagga ttggctgaac     1020

ggcaaggagt acaagtgcaa ggtctccaat aaagccctgc ctgcccctat cgagaaaacc     1080

attagcaaag ccaaaggcca gcccagggag ccccaggtct atacactgcc ccccagcagg     1140

gaggagatga caaaaaatca ggtcagcctg acatgcctgg tcaaaggctt ttatcccagc     1200

gacattgccg tcgagtggga gtccaatggc cagcccgaga ataattataa aacaacaccc     1260

cccgtcctgg acagcgacgg cagctttttt ctgtatagca aactgacagt cgataaaagc     1320

aggtggcagc agggcaatgt cttttcctgc agcgtcatgc acgaggccct gcacaatcac     1380

tatactcaga aaagcctgag cctgtccccc gggaaatgag cggccgc                   1427


<210>  41
<211>  731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   11256A8-LC cDNA

<400>  41
gaattcgccg ccaccatggt gctgcagacc caggtgttca tctccctgct gctgtggatc       60

agcggcgcct acggctcctc cgagctgacc cagcctagct ccgtgagcat gtcccctggc      120

cagaccgcca ggatcacctg ctccggcgat gtgctggcta agaagtacgc taggtggttc      180

cagcagaagc ccggccaggc tcccgtgctg gtgatctaca aggatagcga gcggccctcc      240

ggcatccctg agaggttcag cggcagcagc agcggcacca ccgtgaccct gaccatctcc      300

ggcgtgcagg ccgaggacga ggctgactac tattgccagt ccgctgatag ctccggcacc      360

aggtgggtgt tcggcggcgg aaccaagctg accgtgctgc gtacggtggc tgcaccttct      420

gtgttcatct tccctccatc tgatgagcag ctgaagtctg gaaccgcatc tgtcgtctgt      480

ctgctgaaca acttttaccc cagggaggct aaggtccaat ggaaggtgga caacgccctg      540

cagtctggta atagccagga aagcgtgacc gaacaggatt ccaaggactc cacctactcc      600

ctgtcctcca cactgacact gagcaaagcc gactatgaaa agcacaaagt gtatgcctgc      660

gaggtcactc atcagggcct gtccagcccc gtgactaaaa gctttaatag gggggagtgc      720

tgagcggccg c                                                           731


<210>  42
<211>  1441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256B9-HC cDNA

<400>  42
gaattcgccg ccaccatgaa gcacctgtgg ttcttcctgc tgctggtggc tgctccccgg       60

tgggtgctga gccaggtgca gctggtgcag agcggcgctg aggtgaagaa gcctggcgct      120

tctgtgaagg tgtcctgtaa ggccagcggc tataccttca cctcctacta catgcactgg      180

gtgaggcagg ctcctggcca gggcctggag tggatgggca tcatcaatcc cagcggcggc      240

tccacctcct acgctcagaa gttccagggc cgggtgacca tgaccaggga cacctccacc      300

agcaccgtgt acatggagct gtcctccctg cggagcgagg ataccgccgt gtactattgt      360

gcccggccta ggggcatcag ggcctacgga ggctacagcc tggattattg gggccagggc      420

accctggtga ccgtgtcctc cgctagcacc aagggacctt ctgtgttccc tctggctcct      480

tcttctaagt ccacttccgg tggtacagca gctctgggtt gtctggtgaa ggattacttc      540

ccagaaccag tgactgtgtc ctggaactcc ggagctctga cttctggagt gcatactttc      600

ccagcagtgc tgcaatctag cggactgtac tctctgtctt ccgtggtgac tgtgccttct      660

tcttccctgg ggactcaaac ttacatctgc aacgtgaacc acaagccctc caacaccaag      720

gtggacaaga aggtggagcc aaagagctgc gataagaccc acacctgtcc accttgtcca      780

gctccagaac tgctgggtgg gccttctgtg tttctgttcc cacctaagcc aaaggatacc      840

ctgatgatct ctaggacccc agaagtgacc tgtgtggtcg tcgatgtgtc tcatgaagac      900

cctgaagtga agttcaactg gtacgtggac ggggtggaag tgcataacgc aaagaccaag      960

cccagggaag agcaatacaa ctccacctac agggtggtct ccgtcctgac agtcctgcat     1020

caggttggct gaacggcaag gagtacaagt gcaaggtctc caataaagcc ctgcctgccc     1080

ctatcgagaa aaccattagc aaagccaaag gccagcccag ggagccccag gtctatacac     1140

tgccccccag cagggaggag atgacaaaaa atcaggtcag cctgacatgc ctggtcaaag     1200

gcttttatcc cagcgacatt gccgtcgagt gggagtccaa tggccagccc gagaataatt     1260

ataaaacaac accccccgtc ctggacagcg acggcagctt ttttctgtat agcaaactga     1320

cagtcgataa aagcaggtgg cagcagggca atgtcttttc ctgcagcgtc atgcacgagg     1380

ccctgcacaa tcactatact cagaaaagcc tgagcctgtc ccccgggaaa tgagcggccg     1440

c                                                                     1441


<210>  43
<211>  737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256B9-LC cDNA

<400>  43
gaattcgccg ccaccatggt gctgcagacc caggtgttca tctccctgct gctgtggatc       60

tccggcgcct atggccagac cgtggtgacc caggagccta gcttctccgt gtcccctggc      120

ggcaccgtga ccctgacctg cggactgaac agcggcagcg tgtccagcag gttcttccct      180

agctggtacc agcagacccc cggccagccc ccaagaaccc tgatctatag caccaggatc      240

cggagcagcg gcgtgcctga caggttcagc ggcttcatcc tgggcgacaa ggccgctctg      300

accatcaccg gcgcccaggc tgacgatgag agcgtgtatt actgtctgct gtacatgggc      360

tccggcatct gggtgttcgg cggcggaacc aagctgaccg tgctgcgtac ggtggctgca      420

ccttctgtgt tcatcttccc tccatctgat gagcagctga agtctggaac cgcatctgtc      480

gtctgtctgc tgaacaactt ttaccccagg gaggctaagg tccaatggaa ggtggacaac      540

gccctgcagt ctggtaatag ccaggaaagc gtgaccgaac aggattccaa ggactccacc      600

tactccctgt cctccacact gacactgagc aaagccgact atgaaaagca caaagtgtat      660

gcctgcgagg tcactcatca gggcctgtcc agccccgtga ctaaaagctt taataggggg      720

gagtgctgag cggccgc                                                     737


<210>  44
<211>  1439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256E1-HC cDNA

<400>  44
gaattcgccg ccaccatgaa gcacctgtgg ttcttcctgc tgctggtggc tgccccccgg       60

tgggttctgt cccaggtgca gctggtgcag tccggcggcg gactggtgca gcctggagga      120

tccctgaggc tgagctgcgc tgccagcggc ttcaccttca gctcctacgc tatgtcctgg      180

gtgcggcagg cccccggaaa gggactggag tgggtgagcg ccatctccgg cagcggcgga      240

agcacctact acgccgactc cgtgaagggc aggttcacca tctccaggga taactccaag      300

aacaccctgt atctgcagat gaacagcctg cgggctgagg ataccgccgt gtattactgc      360

gccaagcaca tccggggcca gaggtacttc gcctacatgg atgtgtgggg caagggcacc      420

ctggtgaccg tgtcctccgc tagcaccaag ggaccttctg tgttccctct ggctccttct      480

tctaagtcca cttccggtgg tacagcagct ctgggttgtc tggtgaagga ttacttccca      540

gaaccagtga ctgtgtcctg gaactccgga gctctgactt ctggagtgca tactttccca      600

gcagtgctgc aatctagcgg actgtactct ctgtcttccg tggtgactgt gccttcttct      660

tccctgggga ctcaaactta catctgcaac gtgaaccaca agccctccaa caccaaggtg      720

gacaagaagg tggagccaaa gagctgcgat aagacccaca cctgtccacc ttgtccagct      780

ccagaactgc tgggtgggcc ttctgtgttt ctgttcccac ctaagccaaa ggataccctg      840

atgatctcta ggaccccaga agtgacctgt gtggtcgtcg atgtgtctca tgaagaccct      900

gaagtgaagt tcaactggta cgtggacggg gtggaagtgc ataacgcaaa gaccaagccc      960

agggaagagc aatacaactc cacctacagg gtggtctccg tcctgacagt cctgcatcag     1020

gattggctga acggcaagga gtacaagtgc aaggtctcca ataaagccct gcctgcccct     1080

atcgagaaaa ccattagcaa agccaaaggc cagcccaggg agccccaggt ctatacactg     1140

ccccccagca gggaggagat gacaaaaaat caggtcagcc tgacatgcct ggtcaaaggc     1200

ttttatccca gcgacattgc cgtcgagtgg gagtccaatg gccagcccga gaataattat     1260

aaaacaacac cccccgtcct ggacagcgac ggcagctttt ttctgtatag caaactgaca     1320

gtcgataaaa gcaggtggca gcagggcaat gtcttttcct gcagcgtcat gcacgaggcc     1380

ctgcacaatc actatactca gaaaagcctg agcctgtccc ccgggaaatg agcggccgc      1439


<210>  45
<211>  728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256E1-LC cDNA

<400>  45
gaattcgccg ccaccatggt gctgcagacc caggtgttca tcagcctgct gctgtggatc       60

tccggcgctt atggcgctat ccggatgacc cagagcccca gctccgtgtc cgctagcgtg      120

ggcgacaggg tgaccatcac ctgtagggcc tcccagggca tctcctcccg gctggcttgg      180

tatcagcaga agcccggcaa ggctcccaag ctgctgatct atgctgccag ctccctgcag      240

agcggcgtgc cttcccggtt cagcggctcc ggatccggca ccgacttcac cctgaccatc      300

tccagcgtgc agcctgagga cttcgctacc tactattgtc agcaggccaa ttccttccct      360

ctgaccttcg gcggcggcac caaggtggac atcaagcgta cggtggctgc accttctgtg      420

ttcatcttcc ctccatctga tgagcagctg aagtctggaa ccgcatctgt cgtctgtctg      480

ctgaacaact tttaccccag ggaggctaag gtccaatgga aggtggacaa cgccctgcag      540

tctggtaata gccaggaaag cgtgaccgaa caggattcca aggactccac ctactccctg      600

tcctccacac tgacactgag caaagccgac tatgaaaagc acaaagtgta tgcctgcgag      660

gtcactcatc agggcctgtc cagccccgtg actaaaagct ttaatagggg ggagtgctga      720

gcggccgc                                                               728


<210>  46
<211>  1424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256F3-HC cDNA

<400>  46
gaattcgccg ccaccatgaa gcacctgtgg ttcttcctgc tgctggtggc tgcccctagg       60

tgggtgctga gccaggtgca gctgcagcag agcggcgctg aggtgaagaa gcccggcgcc      120

agcgtgaagg tgagctgtaa ggcttccggc tacaccttca cctcctacta catgcactgg      180

gtgaggcagg ctcccggcca gggactggag tggatgggca tcatcaaccc tagcggcggc      240

tccacctcct acgcccagaa gttccagggc agggtgacca tgaccaggga cacctccacc      300

agcaccgtgt acatggagct gtccagcctg aggagcgagg ataccgctgt gtattactgt      360

gctcgggacc ggcggggcgg cggagactac tggggacagg gaaccctggt gaccgtgagc      420

tccgctagca ccaagggacc ttctgtgttc cctctggctc cttcttctaa gtccacttcc      480

ggtggtacag cagctctggg ttgtctggtg aaggattact tcccagaacc agtgactgtg      540

tcctggaact ccggagctct gacttctgga gtgcatactt tcccagcagt gctgcaatct      600

agcggactgt actctctgtc ttccgtggtg actgtgcctt cttcttccct ggggactcaa      660

acttacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag      720

ccaaagagct gcgataagac ccacacctgt ccaccttgtc cagctccaga actgctgggt      780

gggccttctg tgtttctgtt cccacctaag ccaaaggata ccctgatgat ctctaggacc      840

ccagaagtga cctgtgtggt cgtcgatgtg tctcatgaag accctgaagt gaagttcaac      900

tggtacgtgg acggggtgga agtgcataac gcaaagacca agcccaggga agagcaatac      960

aactccacct acagggtggt ctccgtcctg acagtcctgc atcaggattg gctgaacggc     1020

aaggagtaca agtgcaaggt ctccaataaa gccctgcctg cccctatcga gaaaaccatt     1080

agcaaagcca aaggccagcc cagggagccc caggtctata cactgccccc cagcagggag     1140

gagatgacaa aaaatcaggt cagcctgaca tgcctggtca aaggctttta tcccagcgac     1200

attgccgtcg agtgggagtc caatggccag cccgagaata attataaaac aacacccccc     1260

gtcctggaca gcgacggcag cttttttctg tatagcaaac tgacagtcga taaaagcagg     1320

tggcagcagg gcaatgtctt ttcctgcagc gtcatgcacg aggccctgca caatcactat     1380

actcagaaaa gcctgagcct gtcccccggg aaatgagcgg ccgc                      1424


<210>  47
<211>  737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256F3-LC cDNA

<400>  47
gaattcgccg ccaccatggt gctgcagacc caggtgttca tctccctgct gctgtggatc       60

tccggcgctt atggccaggc tgtggtgacc caggagcctt ccttcagcgt gtcccctggc      120

ggcaccgtga ccctgacctg tggcctgtcc agcggcagcg tgagcaccac ctactaccct      180

tcctggtacc agctgacccc tggccaggcc cctcggacac tgatctataa taccaacacc      240

cggagcagcg gcgtgcccga tcggttcagc ggctccatcc tgggcaataa ggctgctctg      300

accatcaccg gcgctcaggc tgacgatgag agctattact actgtctgct gtacatgggc      360

aggggcgtgc gggtgttcgg cggaggaacc aagctgaccg tgctgcgtac ggtggctgca      420

ccttctgtgt tcatcttccc tccatctgat gagcagctga agtctggaac cgcatctgtc      480

gtctgtctgc tgaacaactt ttaccccagg gaggctaagg tccaatggaa ggtggacaac      540

gccctgcagt ctggtaatag ccaggaaagc gtgaccgaac aggattccaa ggactccacc      600

tactccctgt cctccacact gacactgagc aaagccgact atgaaaagca caaagtgtat      660

gcctgcgagg tcactcatca gggcctgtcc agccccgtga ctaaaagctt taataggggg      720

gagtgctgag cggccgc                                                     737


<210>  48
<211>  1430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256H5-HC cDNA

<400>  48
gaattcgccg ccaccatgaa gcacctgtgg ttcttcctgc tgctggtggc tgcccctcgg       60

tgggtgctgt cccaggtgca gctggtggag agcggcggcg gagtggtgca gccaggaaga      120

agcctgaggc tgagctgtgc cgcttccggc ttcaccttca gctcctacgc tgtgcactgg      180

gtgcggcagg ctcccggaaa gggcctggag tgggtggctg tgatctccta cgatggctcc      240

aacaagtact atgccgactc cgtgaagggc cggttcacca tctcccggga taattccaag      300

aacaccctgt tcctgcagat gaatagcctg agggccgagg acaccgctgt gtactattgc      360

gcccggaggg gcctgcgggg ctatgccttc gatatctggg gccagggcac cctggtgacc      420

gtgtcctccg ctagcaccaa gggaccttct gtgttccctc tggctccttc ttctaagtcc      480

acttccggtg gtacagcagc tctgggttgt ctggtgaagg attacttccc agaaccagtg      540

actgtgtcct ggaactccgg agctctgact tctggagtgc atactttccc agcagtgctg      600

caatctagcg gactgtactc tctgtcttcc gtggtgactg tgccttcttc ttccctgggg      660

actcaaactt acatctgcaa cgtgaaccac aagccctcca acaccaaggt ggacaagaag      720

gtggagccaa agagctgcga taagacccac acctgtccac cttgtccagc tccagaactg      780

ctgggtgggc cttctgtgtt tctgttccca cctaagccaa aggataccct gatgatctct      840

aggaccccag aagtgacctg tgtggtcgtc gatgtgtctc atgaagaccc tgaagtgaag      900

ttcaactggt acgtggacgg ggtggaagtg cataacgcaa agaccaagcc cagggaagag      960

caatacaact ccacctacag ggtggtctcc gtcctgacag tcctgcatca ggattggctg     1020

aacggcaagg agtacaagtg caaggtctcc aataaagccc tgcctgcccc tatcgagaaa     1080

accattagca aagccaaagg ccagcccagg gagccccagg tctatacact gccccccagc     1140

agggaggaga tgacaaaaaa tcaggtcagc ctgacatgcc tggtcaaagg cttttatccc     1200

agcgacattg ccgtcgagtg ggagtccaat ggccagcccg agaataatta taaaacaaca     1260

ccccccgtcc tggacagcga cggcagcttt tttctgtata gcaaactgac agtcgataaa     1320

agcaggtggc agcagggcaa tgtcttttcc tgcagcgtca tgcacgaggc cctgcacaat     1380

cactatactc agaaaagcct gagcctgtcc cccgggaaat gagcggccgc                1430


<210>  49
<211>  725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11256H5-LC cDNA

<400>  49
gaattcgccg ccaccatggt gctgcagacc caggtgttca tctccctgct gctgtggatc       60

tccggcgctt atggctccta cgtgctgacc cagcctagca gcgtgtccgt gtcccctggc      120

cagaccgcta ggatcacctg tagcggcgat gtgctggcca agaagtacgc tcggtggttc      180

cagcagaagc ctggccagcc tcctgtgctg ctgatctata aggacaccga gcggcctagc      240

ggcatccctg agaggttctc cggctcctcc tccggcacca ccgctaccct gaccatctcc      300

ggcgcccagg ctgaggatga ggccgattac tattgctaca gcgctgccga caataagggc      360

ttcttcggca ccggcaccaa ggtgaccgtg ctgcgtacgg tggctgcacc ttctgtgttc      420

atcttccctc catctgatga gcagctgaag tctggaaccg catctgtcgt ctgtctgctg      480

aacaactttt accccaggga ggctaaggtc caatggaagg tggacaacgc cctgcagtct      540

ggtaatagcc aggaaagcgt gaccgaacag gattccaagg actccaccta ctccctgtcc      600

tccacactga cactgagcaa agccgactat gaaaagcaca aagtgtatgc ctgcgaggtc      660

actcatcagg gcctgtccag ccccgtgact aaaagcttta atagggggga gtgctgagcg      720

gccgc                                                                  725


<210>  50
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SDC2 Human

<400>  50

Leu Pro Lys Ile Leu Leu Thr Ser Ala Ala Pro Lys Val Glu Thr Thr 
1               5                   10                  15      


Thr Leu Asn Ile Gln Asn Lys Ile Pro Ala Gln Thr Lys Ser Pro Glu 
            20                  25                  30          


Glu Thr Asp Lys Glu Lys Val His Leu Ser Asp Ser Glu Arg Lys Met 
        35                  40                  45              


Asp Pro Ala Glu Glu Asp Thr Asn Val Tyr Thr Glu Lys His Ser Asp 
    50                  55                  60                  


Ser Leu Phe Lys 
65              


<210>  51
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SDC2 Mouse

<400>  51

Ile Pro Arg Ile Pro Leu Thr Ser Ala Ala Ser Pro Lys Val Glu Thr 
1               5                   10                  15      


Met Thr Leu Lys Thr Gln Ser Ile Thr Pro Ala Gln Thr Glu Ser Pro 
            20                  25                  30          


Glu Glu Thr Asp Lys Glu Glu Val Asp Ile Ser Glu Ala Glu Glu Lys 
        35                  40                  45              


Leu Gly Pro Ala Ile Lys Ser Thr Asp Val Tyr Thr Glu Lys His Ser 
    50                  55                  60                  


Asp Asn Leu Phe Lys 
65                  


