                         SEQUENCE LISTING

<110>  FUNDACI PRIVADA INSTITUT D'INVESTIGACI ONCOLGICA DE VALL
        HEBRON
       INSTITUCI CATALANA DE RECERCA I ESTUDIS AVANATS
 
<120>  CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR P95HER2 AND USES THEREOF

<130>  P18520PC00

<140>  PCT/EP2021/064383
<141>  2021-05-28

<150>  EP20382457.8
<151>  2020-05-28

<160>  202   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH m32H2

<400>  1

Asp Phe Gly Met Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH m32H2

<400>  2

Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Asn Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH m32H2

<400>  3

Glu Gly Leu Asp Tyr 
1               5   


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL m32H2

<400>  4

Lys Ala Ser Gln Ser Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL m32H2

<400>  5

Ser Ala Ser Asn Arg Phe Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL m32H2

<400>  6

Gln Gln Tyr Ser Thr Tyr Pro Leu Ala 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH 214D8

<400>  7

Thr Tyr Gly Met Ala 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH 214D8

<400>  8

Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH 214D8

<400>  9

Glu Gly Phe Asp Tyr 
1               5   


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL 214D8

<400>  10

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL 214VL

<400>  11

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL 214D8

<400>  12

Gln Gln Tyr Ser Thr Tyr Pro Leu Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VH 215C2

<400>  13

Asp Tyr Gly Met Ser 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH 215C2

<400>  14

Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VH 215C2

<400>  15

Glu Gly Phe Asp Tyr 
1               5   


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL 215C2

<400>  16

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VL 215C2

<400>  17

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 VL 215C2

<400>  18

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH  H1-32H2

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            20                  25                  30  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H1-32H2

<400>  20

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  21
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH  H1-32H2

<400>  21

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  H1-32H2

<400>  22

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  23
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  H1-32H2

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H1-32H2

<400>  24

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  25
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  H1-32H2

<400>  25

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  H1-32H2

<400>  26

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  (FRs H1-32H2 and CDRs m32H2)

<400>  27

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  (FRs H1 32H2 and CDRs m32H2)

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker coneting VH and VL regions

<400>  29

Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
1               5                   10                  15      


<210>  30
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH (CDRs m32H2 and FRs H1 32H2)

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Asn Thr 
                165                 170                 175     


Asn Gly Gly Thr Thr His Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Gly Leu 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH 214D8

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH 214D8

<400>  32

Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val Ala 
1               5                   10                  


<210>  33
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH 214D8

<400>  33

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH 214D8

<400>  34

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  35
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL 214D8

<400>  35

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys 
            20              


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL 214D8

<400>  36

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile Tyr 
1               5                   10                  15  


<210>  37
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL 214C8

<400>  37

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asn Met Lys Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL 214D8

<400>  38

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL 214D8

<400>  39

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Lys Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  40
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 214D8

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  41
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  214D8  VL-VH

<400>  41

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Lys Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ala Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val Ala Thr Ile Asn Ser 
                165                 170                 175     


Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser 
        195                 200                 205             


Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235         


<210>  42
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH 215C2

<400>  42

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH 215C2

<400>  43

Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala 
1               5                   10                  


<210>  44
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH 215C2

<400>  44

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Pro Arg 
            20                  25                  30          


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH 215C2

<400>  45

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  46
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL 215C2

<400>  46

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys 
            20              


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL 215C2

<400>  47

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr 
1               5                   10                  15  


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL 215C2

<400>  48

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL 215C2

<400>  49

Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
1               5                   10  


<210>  50
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL 215C2

<400>  50

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105         


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 215C2

<400>  51

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  52
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  215C2  VL-VH

<400>  52

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val His Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala Thr Ile Asn Gly 
                165                 170                 175     


Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Pro Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235         


<210>  53
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  H1-214D8

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  54
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  H1-214D8

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  55
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  H2-214D8

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  56
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  H2-214D8

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  H1-215C2

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  H1-215C2

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  61
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  H2-215C2

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  H2-215C2

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH  H1-214D8

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H1-214D8

<400>  66

Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val Ala 
1               5                   10                  


<210>  67
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH  H1-214D8

<400>  67

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  H1-214D8

<400>  68

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  H1-214D8

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL  H1-214D8

<400>  70

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  H1-214D8

<400>  71

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  H1-214D8

<400>  72

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  73
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH  H2-214D8

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H2-214D8

<400>  74

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  75
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH  H2-214D8

<400>  75

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  H2-214D8

<400>  76

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  77
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  H2-214D8

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL  H2-214D8

<400>  78

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile Tyr 
1               5                   10                  15  


<210>  79
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  H2-214D8

<400>  79

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  H2-214D8

<400>  80

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH  H1-215C2

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  90
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H1-215C2

<400>  90

Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Leu Val Ala 
1               5                   10                  


<210>  91
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH  H1-215C2

<400>  91

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Pro Arg 
            20                  25                  30          


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  H1-215C2

<400>  92

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  93
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  H1-215C2

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL  H1-215C2

<400>  94

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile Tyr 
1               5                   10                  15  


<210>  95
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  H1-215C2

<400>  95

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  H1-215C2

<400>  96

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  97
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH  H2-215C2

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  98
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H2-215C2

<400>  98

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  99
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH  H2-215C2

<400>  99

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Pro Arg 
            20                  25                  30          


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  H2-215C2

<400>  100

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  101
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  H2-215C2

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL  H2-215C2

<400>  102

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile Tyr 
1               5                   10                  15  


<210>  103
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  H2-215C2

<400>  103

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  H2-215C2

<400>  104

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  105

<400>  105
000

<210>  106

<400>  106
000

<210>  107

<400>  107
000

<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110

<400>  110
000

<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  113

Phe Trp Val Leu Val Val Val Gly Gly Asx Cys Val Leu Ala Cys Tyr 
1               5                   10                  15      


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25                  


<210>  114
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta intracellular signalling domain

<400>  114

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  115
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellualr domain of the coestimulatory domain CD28

<400>  115

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  116
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spacer

<400>  116

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  117

Gly Ser Gly Gly Ser 
1               5   


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  118

Gly Gly Gly Ser 
1               


<210>  119
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  119

Gly Gly Ser Gly 
1               


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  120

Gly Gly Ser Gly Gly 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  121

Gly Ser Gly Ser Gly 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  122

Gly Ser Gly Gly Gly 
1               5   


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  123

Gly Gly Gly Ser Gly 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  124

Gly Ser Ser Ser Gly 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  125

Gly Ser Gly Gly Ser 
1               5   


<210>  126
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  126

Gly Gly Gly Ser 
1               


<210>  127
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  127

Gly Gly Ser Gly 
1               


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  128

Gly Gly Ser Gly Gly 
1               5   


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  129

Gly Ser Gly Ser Gly 
1               5   


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  130

Gly Ser Gly Gly Gly 
1               5   


<210>  131
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  131

Gly Gly Gly Ser Gly 
1               5   


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  132

Gly Ser Ser Ser Gly 
1               5   


<210>  133
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  133

Cys Pro Pro Cys 
1               


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  134

Asp Lys Thr His Thr 
1               5   


<210>  135

<400>  135
000

<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  136

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  137

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  138

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  139

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  140

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  141

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  142
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  142

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  143
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  143

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  144

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  145

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  146
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  146

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  147
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  147

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 Vh m32H2

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            20                  25                  30  


<210>  153
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH m32H2

<400>  153

Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala 
1               5                   10                  


<210>  154
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH m32H2

<400>  154

Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Phe Val Tyr Leu 
1               5                   10                  15      


Gln Met Ser Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Pro 
            20                  25                  30          


Arg 
    


<210>  155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  m32H2

<400>  155

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  156
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  m32H2

<400>  156

Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys 
            20              


<210>  157
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL  m32H2

<400>  157

Trp Tyr Gln Leu Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  158
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  m32H2

<400>  158

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
            20                  25                  30          


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  m32H2

<400>  159

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  160
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  m32H2

<400>  160

Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  161
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  m32H2

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Phe Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Glu Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  162
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH m32H2

<400>  162

Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Lys Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Gly Met Ser Trp Ile 
145                 150                 155                 160 


Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala Thr Ile Asn Thr 
                165                 170                 175     


Asn Gly Gly Thr Thr His Tyr Pro Asp Asn Val Lys Gly Arg Phe Ser 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Lys Phe Val Tyr Leu Gln Met Ser Ser 
        195                 200                 205             


Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Pro Arg Glu Gly Leu 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235         


<210>  163
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VH   H2-32H2

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            20                  25                  30  


<210>  164
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VH  H2-32H2

<400>  164

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  165
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VH  H2-32H2

<400>  165

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Phe Val Tyr Leu 
1               5                   10                  15      


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Pro 
            20                  25                  30          


Arg 
    


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VH  H2-32H2

<400>  166

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  167
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1 VL  H2-32H2

<400>  167

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2 VL  H2-32H2

<400>  168

Trp Tyr Gln Leu Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  169
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3 VL  H2-32H2

<400>  169

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4 VL  H2-32H2

<400>  170

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  H2-32H2

<400>  171

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  172
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  H2-32H2

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Phe Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Glu Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  173
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H2-32H2

<400>  173

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Asn Thr 
                165                 170                 175     


Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Lys Phe Val Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Pro Arg Glu Gly Leu 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 VH  H1-32H2

<400>  174

Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL  H1-32H2

<400>  175

Arg Ala Ser Gln Ser Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 VL  H2-215C2

<400>  179

Arg Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  180
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL ScFv1 H1-32H2 (CDR2 174)

<400>  180

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  181
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  H1-32H2 CDR1 175

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Glu Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  182
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H1-32H2 (VL CDR2 174 and VH CDR1 175)

<400>  182

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Asn Thr 
                165                 170                 175     


Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val Lys Gly Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu Gly 
    210                 215                 220                 


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235             


<210>  183

<400>  183
000

<210>  184
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL 215C2 (CDR 179)

<400>  184

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
            100                 105         


<210>  185

<400>  185
000

<210>  186
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH 215C2 (VL 184)

<400>  186

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Glu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val His Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala Thr Ile Asn Gly 
                165                 170                 175     


Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Pro Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235         


<210>  187
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H1-214D8

<400>  187

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ala Trp Val 
145                 150                 155                 160 


Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val Ala Thr Ile Asn Ser 
                165                 170                 175     


Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  188
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H2-214D8

<400>  188

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met Ala Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Asn Ser 
                165                 170                 175     


Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  189
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H3-214D8

<400>  189

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Ala Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Ser 
                165                 170                 175     


Asn Gly Gly Lys Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Asp Tyr Trp 
    210                 215                 220                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 


<210>  190
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H1-215C2

<400>  190

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Arg Leu Glu Leu Val Ala Thr Ile Asn Gly 
                165                 170                 175     


Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Pro Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  191
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH  H2-215C2

<400>  191

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Gly Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Asn Gly 
                165                 170                 175     


Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Pro Arg Glu Gly Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235         


<210>  192

<400>  192
000

<210>  193
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL  m32H2 (CDR1 VL 175)

<400>  193

Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Arg Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  194
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH  m32H2 (CDR2 VH 174)

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Lys Phe Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Pro Arg Glu Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  195
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-VH m32H2 (193 and 194)

<400>  195

Asp Ile Val Leu Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Ile Cys Arg Ala Ser Gln Ser Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Leu Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Phe Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Thr Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Gly Ser Thr Ser 
            100                 105                 110         


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Ile Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Gly Met Ser Trp Ile 
145                 150                 155                 160 


Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val Ala Thr Ile Asn Thr 
                165                 170                 175     


Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val Lys Gly Gly Arg Phe 
            180                 185                 190         


Ser Ile Ser Arg Asp Asn Ala Lys Lys Phe Val Tyr Leu Gln Met Ser 
        195                 200                 205             


Ser Leu Lys Ser Asp Asp Thr Ala Ile Tyr Tyr Cys Pro Arg Glu Gly 
    210                 215                 220                 


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235             


<210>  196
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 32H2 CAR

<400>  196

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Ser Ala Ser Asn Arg Phe Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Thr Tyr Pro Leu Ala Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
                165                 170                 175     


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Thr Ile Asn Thr Asn Gly Gly Thr Thr His Tyr Pro Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Lys Glu Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  197
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  214D8 CAR

<400>  197

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Ile Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Asn Met Lys Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
            100                 105                 110         


Ser Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
                165                 170                 175     


Gly Met Ala Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val 
            180                 185                 190         


Ala Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
225                 230                 235                 240 


Thr Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  198
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1 214D8 CAR

<400>  198

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Ala Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Ile Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Thr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
                165                 170                 175     


Gly Met Ala Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Leu Val 
            180                 185                 190         


Ala Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  199
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 214D8 CAR

<400>  199

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Ala Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Ile Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Thr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
                165                 170                 175     


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Thr Ile Asn Ser Asn Gly Gly Lys Thr Tyr His Pro Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  200
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  215C2 CAR

<400>  200

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Glu Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Val Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
            100                 105                 110         


Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
                165                 170                 175     


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
            180                 185                 190         


Ala Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Pro Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  201
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1 215C2 CAR

<400>  201

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Ala Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Val Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
                165                 170                 175     


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Leu Val 
            180                 185                 190         


Ala Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Pro Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  202
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2 215C2 CAR

<400>  202

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Ala Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Ser Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
                165                 170                 175     


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ala Thr Ile Asn Gly Asn Gly Val Lys Ile Tyr Tyr Val Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Pro Arg Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


