                               SEQUENCE LISTING

<110> MAMMOTH BIOSCIENCES, INC.
 
<120> PROGRAMMABLE NUCLEASE DIAGNOSTIC DEVICE

<130> 53694-754.601

<140> PCT/US2021/035031
<141> 2021-05-28

<150> 63/181,130
<151> 2021-04-28

<150> 63/166,538
<151> 2021-03-26

<150> 63/151,592
<151> 2021-02-19

<150> 63/113,798
<151> 2020-11-13

<150> 63/032,455
<151> 2020-05-29

<160> 74    

<170> PatentIn version 3.5

<210> 1
<211> 529
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Ala Lys Asn Thr Ile Thr Lys Thr Leu Lys Leu Arg Ile Val Arg 
1               5                   10                  15      


Pro Tyr Asn Ser Ala Glu Val Glu Lys Ile Val Ala Asp Glu Lys Asn 
            20                  25                  30          


Asn Arg Glu Lys Ile Ala Leu Glu Lys Asn Lys Asp Lys Val Lys Glu 
        35                  40                  45              


Ala Cys Ser Lys His Leu Lys Val Ala Ala Tyr Cys Thr Thr Gln Val 
    50                  55                  60                  


Glu Arg Asn Ala Cys Leu Phe Cys Lys Ala Arg Lys Leu Asp Asp Lys 
65                  70                  75                  80  


Phe Tyr Gln Lys Leu Arg Gly Gln Phe Pro Asp Ala Val Phe Trp Gln 
                85                  90                  95      


Glu Ile Ser Glu Ile Phe Arg Gln Leu Gln Lys Gln Ala Ala Glu Ile 
            100                 105                 110         


Tyr Asn Gln Ser Leu Ile Glu Leu Tyr Tyr Glu Ile Phe Ile Lys Gly 
        115                 120                 125             


Lys Gly Ile Ala Asn Ala Ser Ser Val Glu His Tyr Leu Ser Asp Val 
    130                 135                 140                 


Cys Tyr Thr Arg Ala Ala Glu Leu Phe Lys Asn Ala Ala Ile Ala Ser 
145                 150                 155                 160 


Gly Leu Arg Ser Lys Ile Lys Ser Asn Phe Arg Leu Lys Glu Leu Lys 
                165                 170                 175     


Asn Met Lys Ser Gly Leu Pro Thr Thr Lys Ser Asp Asn Phe Pro Ile 
            180                 185                 190         


Pro Leu Val Lys Gln Lys Gly Gly Gln Tyr Thr Gly Phe Glu Ile Ser 
        195                 200                 205             


Asn His Asn Ser Asp Phe Ile Ile Lys Ile Pro Phe Gly Arg Trp Gln 
    210                 215                 220                 


Val Lys Lys Glu Ile Asp Lys Tyr Arg Pro Trp Glu Lys Phe Asp Phe 
225                 230                 235                 240 


Glu Gln Val Gln Lys Ser Pro Lys Pro Ile Ser Leu Leu Leu Ser Thr 
                245                 250                 255     


Gln Arg Arg Lys Arg Asn Lys Gly Trp Ser Lys Asp Glu Gly Thr Glu 
            260                 265                 270         


Ala Glu Ile Lys Lys Val Met Asn Gly Asp Tyr Gln Thr Ser Tyr Ile 
        275                 280                 285             


Glu Val Lys Arg Gly Ser Lys Ile Gly Glu Lys Ser Ala Trp Met Leu 
    290                 295                 300                 


Asn Leu Ser Ile Asp Val Pro Lys Ile Asp Lys Gly Val Asp Pro Ser 
305                 310                 315                 320 


Ile Ile Gly Gly Ile Asp Val Gly Val Lys Ser Pro Leu Val Cys Ala 
                325                 330                 335     


Ile Asn Asn Ala Phe Ser Arg Tyr Ser Ile Ser Asp Asn Asp Leu Phe 
            340                 345                 350         


His Phe Asn Lys Lys Met Phe Ala Arg Arg Arg Ile Leu Leu Lys Lys 
        355                 360                 365             


Asn Arg His Lys Arg Ala Gly His Gly Ala Lys Asn Lys Leu Lys Pro 
    370                 375                 380                 


Ile Thr Ile Leu Thr Glu Lys Ser Glu Arg Phe Arg Lys Lys Leu Ile 
385                 390                 395                 400 


Glu Arg Trp Ala Cys Glu Ile Ala Asp Phe Phe Ile Lys Asn Lys Val 
                405                 410                 415     


Gly Thr Val Gln Met Glu Asn Leu Glu Ser Met Lys Arg Lys Glu Asp 
            420                 425                 430         


Ser Tyr Phe Asn Ile Arg Leu Arg Gly Phe Trp Pro Tyr Ala Glu Met 
        435                 440                 445             


Gln Asn Lys Ile Glu Phe Lys Leu Lys Gln Tyr Gly Ile Glu Ile Arg 
    450                 455                 460                 


Lys Val Ala Pro Asn Asn Thr Ser Lys Thr Cys Ser Lys Cys Gly His 
465                 470                 475                 480 


Leu Asn Asn Tyr Phe Asn Phe Glu Tyr Arg Lys Lys Asn Lys Phe Pro 
                485                 490                 495     


His Phe Lys Cys Glu Lys Cys Asn Phe Lys Glu Asn Ala Asp Tyr Asn 
            500                 505                 510         


Ala Ala Leu Asn Ile Ser Asn Pro Lys Leu Lys Ser Thr Lys Glu Glu 
        515                 520                 525             


Pro 
    


<210> 2
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      NLS sequence

<400> 2
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Glu Phe 
        


<210> 3
<211> 51
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
ggccacccca aaaaugaagg ggacuaaaac agugauaagu ggaaugccau g                51


<210> 4
<211> 51
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ggccacccca aaaaugaagg ggacuaaaac acgaccuacu cucccauacu c                51


<210> 5
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 6
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 7
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 7
tttttuaauu ucuacuaagu guagaucccc cagcgcuuca gcguuc                      46


<210> 8
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 8
tttttttttt uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                51


<210> 9
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 9
uaauuucuau cuaaguguag aucccccagc gcuucagcgu uc                          42


<210> 10
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 10
uaauuucuac uaaguguaga ucuccccagc gcuucagcgu uc                          42


<210> 11
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 11
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 12
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 12
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 13
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 14
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 15
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 16
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ttattatt                                                                 8


<210> 17
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ttattatt                                                                 8


<210> 18
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ttattattat tatt                                                         14


<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ttttattatt attattatt                                                    19


<210> 20
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
ttattattat ta                                                           12


<210> 21
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
tttttttttt tttttttttt tttttttttt                                        30


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
tttttttttt tttttttttt                                                   20


<210> 23
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
tttttttttt tttttttttt ttt                                               23


<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
tttttttttt tttttttttt tt                                                22


<210> 25
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
tttttttttt tttttttttt ttt                                               23


<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
tttttttttt tttttttttt t                                                 21


<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
tttttttttt tttttttttt tt                                                22


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
tttttttttt tttttttttt t                                                 21


<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 29
tttttttttt ttuuuuuttt ttt                                               23


<210> 30
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
tttttttttt tt                                                           12


<210> 31
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
tttttttttt ttt                                                          13


<210> 32
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
tttttttttt tt                                                           12


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
tttttttttt tttttttttt t                                                 21


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
tttttttttt tttttttttt t                                                 21


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
tttttttttt tttttttttt                                                   20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
tttttttttt tttttttttt                                                   20


<210> 37
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 38
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 39
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 40
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 41
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
uaauuucuac uaaguguaga uuuacauggc ucugguccga g                           41


<210> 42
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
uaauuucuac uaaguguaga ugccgauaau gauguaggga u                           41


<210> 43
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 44
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
tttttttttt tttttttttt ttt                                               23


<210> 45
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
uaauuucuac uaaguguaga ugccgauaau gauguaggga u                           41


<210> 46
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
uaauuucuac uaaguguaga uuuacauggc ucugguccga g                           41


<210> 47
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
uaauuucuac uaaguguaga ucugccaauu gcaggaauga u                           41


<210> 48
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
tttttttttt ttt                                                          13


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
tttttttttt tttttttttt                                                   20


<210> 50
<211> 1224
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Lys Lys Ile Asp Asn Phe Val Gly Cys Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Ile Gly Lys Thr Gln Glu Asn Ile Glu 
            20                  25                  30          


Lys Lys Arg Leu Val Glu Glu Asp Glu Val Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Leu Ile Asp Arg Tyr His Arg Glu Phe Ile Glu Gly 
    50                  55                  60                  


Val Leu Asp Asn Val Lys Leu Asp Gly Leu Glu Glu Tyr Tyr Met Leu 
65                  70                  75                  80  


Phe Asn Lys Ser Asp Arg Glu Glu Ser Asp Asn Lys Lys Ile Glu Ile 
                85                  90                  95      


Met Glu Glu Arg Phe Arg Arg Val Ile Ser Lys Ser Phe Lys Asn Asn 
            100                 105                 110         


Glu Glu Tyr Lys Lys Ile Phe Ser Lys Lys Ile Ile Glu Glu Ile Leu 
        115                 120                 125             


Pro Asn Tyr Ile Lys Asp Glu Glu Glu Lys Glu Leu Val Lys Gly Phe 
    130                 135                 140                 


Lys Gly Phe Tyr Thr Ala Phe Val Gly Tyr Ala Gln Asn Arg Glu Asn 
145                 150                 155                 160 


Met Tyr Ser Asp Glu Lys Lys Ser Thr Ala Ile Ser Tyr Arg Ile Val 
                165                 170                 175     


Asn Glu Asn Met Pro Arg Phe Ile Thr Asn Ile Lys Val Phe Glu Lys 
            180                 185                 190         


Ala Lys Ser Ile Leu Asp Val Asp Lys Ile Asn Glu Ile Asn Glu Tyr 
        195                 200                 205             


Ile Leu Asn Asn Asp Tyr Tyr Val Asp Asp Phe Phe Asn Ile Asp Phe 
    210                 215                 220                 


Phe Asn Tyr Val Leu Asn Gln Lys Gly Ile Asp Ile Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Ile Val Thr Gly Asp Gly Arg Lys Ile Gln Gly Leu Asn 
                245                 250                 255     


Glu Cys Ile Asn Leu Tyr Asn Gln Glu Asn Lys Lys Ile Arg Leu Pro 
            260                 265                 270         


Gln Phe Lys Pro Leu Tyr Lys Gln Ile Leu Ser Glu Ser Glu Ser Met 
        275                 280                 285             


Ser Phe Tyr Ile Asp Glu Ile Glu Ser Asp Asp Met Leu Ile Asp Met 
    290                 295                 300                 


Leu Lys Glu Ser Leu Gln Ile Asp Ser Thr Ile Asn Asn Ala Ile Asp 
305                 310                 315                 320 


Asp Leu Lys Val Leu Phe Asn Asn Ile Phe Asp Tyr Asp Leu Ser Gly 
                325                 330                 335     


Ile Phe Ile Asn Asn Gly Leu Pro Ile Thr Thr Ile Ser Asn Asp Val 
            340                 345                 350         


Tyr Gly Gln Trp Ser Thr Ile Ser Asp Gly Trp Asn Glu Arg Tyr Asp 
        355                 360                 365             


Val Leu Ser Asn Ala Lys Asp Lys Glu Ser Glu Lys Tyr Phe Glu Lys 
    370                 375                 380                 


Arg Arg Lys Glu Tyr Lys Lys Val Lys Ser Phe Ser Ile Ser Asp Leu 
385                 390                 395                 400 


Gln Glu Leu Gly Gly Lys Asp Leu Ser Ile Cys Lys Lys Ile Asn Glu 
                405                 410                 415     


Ile Ile Ser Glu Met Ile Asp Asp Tyr Lys Ser Lys Ile Glu Glu Ile 
            420                 425                 430         


Gln Tyr Leu Phe Asp Ile Lys Glu Leu Glu Lys Pro Leu Val Thr Asp 
        435                 440                 445             


Leu Asn Lys Ile Glu Leu Ile Lys Asn Ser Leu Asp Gly Leu Lys Arg 
    450                 455                 460                 


Ile Glu Arg Tyr Val Ile Pro Phe Leu Gly Thr Gly Lys Glu Gln Asn 
465                 470                 475                 480 


Arg Asp Glu Val Phe Tyr Gly Tyr Phe Ile Lys Cys Ile Asp Ala Ile 
                485                 490                 495     


Lys Glu Ile Asp Gly Val Tyr Asn Lys Thr Arg Asn Tyr Leu Thr Lys 
            500                 505                 510         


Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Glu Asn Pro Gln 
        515                 520                 525             


Leu Met Gly Gly Trp Asp Arg Asn Lys Glu Ser Asp Tyr Arg Ser Thr 
    530                 535                 540                 


Leu Leu Arg Lys Asn Gly Lys Tyr Tyr Val Ala Ile Ile Asp Lys Ser 
545                 550                 555                 560 


Ser Ser Asn Cys Met Met Asn Ile Glu Glu Asp Glu Asn Asp Asn Tyr 
                565                 570                 575     


Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
            580                 585                 590         


Lys Val Phe Phe Ser Lys Lys Asn Arg Glu Tyr Phe Ala Pro Ser Lys 
        595                 600                 605             


Glu Ile Glu Arg Ile Tyr Ser Thr Gly Thr Phe Lys Lys Asp Thr Asn 
    610                 615                 620                 


Phe Val Lys Lys Asp Cys Glu Asn Leu Ile Thr Phe Tyr Lys Asp Ser 
625                 630                 635                 640 


Leu Asp Arg His Glu Asp Trp Ser Lys Ser Phe Asp Phe Ser Phe Lys 
                645                 650                 655     


Glu Ser Ser Ala Tyr Arg Asp Ile Ser Glu Phe Tyr Arg Asp Val Glu 
            660                 665                 670         


Lys Gln Gly Tyr Arg Val Ser Phe Asp Leu Leu Ser Ser Asn Ala Val 
        675                 680                 685             


Asn Thr Leu Val Glu Glu Gly Lys Leu Tyr Leu Phe Gln Leu Tyr Asn 
    690                 695                 700                 


Lys Asp Phe Ser Glu Lys Ser His Gly Ile Pro Asn Leu His Thr Met 
705                 710                 715                 720 


Tyr Phe Arg Ser Leu Phe Asp Asp Asn Asn Lys Gly Asn Ile Arg Leu 
                725                 730                 735     


Asn Gly Gly Ala Glu Met Phe Met Arg Arg Ala Ser Leu Asn Lys Gln 
            740                 745                 750         


Asp Val Thr Val His Lys Ala Asn Gln Pro Ile Lys Asn Lys Asn Leu 
        755                 760                 765             


Leu Asn Pro Lys Lys Thr Thr Thr Leu Pro Tyr Asp Val Tyr Lys Asp 
    770                 775                 780                 


Lys Arg Phe Thr Glu Asp Gln Tyr Glu Val His Ile Pro Ile Thr Met 
785                 790                 795                 800 


Asn Lys Val Pro Asn Asn Pro Tyr Lys Ile Asn His Met Val Arg Glu 
                805                 810                 815     


Gln Leu Val Lys Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg Gly 
            820                 825                 830         


Glu Arg Asn Leu Ile Tyr Val Val Val Val Asp Gly Gln Gly His Ile 
        835                 840                 845             


Val Glu Gln Leu Ser Leu Asn Glu Ile Ile Asn Glu Asn Asn Gly Ile 
    850                 855                 860                 


Ser Ile Arg Thr Asp Tyr His Thr Leu Leu Asp Ala Lys Glu Arg Glu 
865                 870                 875                 880 


Arg Asp Glu Ser Arg Lys Gln Trp Lys Gln Ile Glu Asn Ile Lys Glu 
                885                 890                 895     


Leu Lys Glu Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys Glu Leu 
            900                 905                 910         


Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser Gly 
        915                 920                 925             


Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
    930                 935                 940                 


Glu Lys Met Leu Ile Thr Lys Leu Asn Tyr Met Val Asp Lys Lys Lys 
945                 950                 955                 960 


Asp Tyr Asn Lys Pro Gly Gly Val Leu Asn Gly Tyr Gln Leu Thr Thr 
                965                 970                 975     


Gln Phe Glu Ser Phe Ser Lys Met Gly Thr Gln Asn Gly Ile Met Phe 
            980                 985                 990         


Tyr Ile Pro Ala Trp Leu Thr Ser  Lys Met Asp Pro Thr  Thr Gly Phe 
        995                 1000                 1005             


Val Asp  Leu Leu Lys Pro Lys  Tyr Lys Asn Lys Ala  Asp Ala Gln 
    1010                 1015                 1020             


Lys Phe  Phe Ser Gln Phe Asp  Ser Ile Arg Tyr Asp  Asn Gln Glu 
    1025                 1030                 1035             


Asp Ala  Phe Val Phe Lys Val  Asn Tyr Thr Lys Phe  Pro Arg Thr 
    1040                 1045                 1050             


Asp Ala  Asp Tyr Asn Lys Glu  Trp Glu Ile Tyr Thr  Asn Gly Glu 
    1055                 1060                 1065             


Arg Ile  Arg Val Phe Arg Asn  Pro Lys Lys Asn Asn  Glu Tyr Asp 
    1070                 1075                 1080             


Tyr Glu  Thr Val Asn Val Ser  Glu Arg Met Lys Glu  Leu Phe Asp 
    1085                 1090                 1095             


Ser Tyr  Asp Leu Leu Tyr Asp  Lys Gly Glu Leu Lys  Glu Thr Ile 
    1100                 1105                 1110             


Cys Glu  Met Glu Glu Ser Lys  Phe Phe Glu Glu Leu  Ile Lys Leu 
    1115                 1120                 1125             


Phe Arg  Leu Thr Leu Gln Met  Arg Asn Ser Ile Ser  Gly Arg Thr 
    1130                 1135                 1140             


Asp Val  Asp Tyr Leu Ile Ser  Pro Val Lys Asn Ser  Asn Gly Tyr 
    1145                 1150                 1155             


Phe Tyr  Asn Ser Asn Asp Tyr  Lys Lys Glu Gly Ala  Lys Tyr Pro 
    1160                 1165                 1170             


Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1175                 1180                 1185             


Leu Trp  Ala Ile Glu Gln Phe  Lys Met Ala Asp Glu  Asp Lys Leu 
    1190                 1195                 1200             


Asp Lys  Thr Lys Ile Ser Ile  Lys Asn Gln Glu Trp  Leu Glu Tyr 
    1205                 1210                 1215             


Ala Gln  Thr His Cys Glu 
    1220                 


<210> 51
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
cuucacugau aaaguggaga accgcuucac caaaagcugu cccuuagggg auuagaacuu       60

gagugaaggu gggcugcuug caucagccua augucgagaa gugcuuucuu cggaaaguaa      120

cccucgaaac aaauucauuu                                                  140


<210> 52
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
guugcagaac ccgaauagac gaaugaagga augcaacccc ccagcgcuuc agcguuc          57


<210> 53
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
guugcagaac ccgaauagac gaaugaagga augcaacgcc gauaaugaug uagggau          57


<210> 54
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
guugcagaac ccgaauagac gaaugaagga augcaacugg cacugagaau uugacua          57


<210> 55
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
guugcagaac ccgaauagac gaaugaagga augcaacuac aagugccugu agguaua          57


<210> 56
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 56
gctcagtatu uuuuatactg accgcctcac ctctctttuu uuuaaacaga gg               52


<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
ttacaaacat tggccgcaaa                                                   20


<210> 58
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
gcgcgacatt ccgaagaa                                                     18


<210> 59
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
uaauuucuac uaaguguaga ucccccagcg cuucagcguu c                           41


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
cctccgtgat atggctcttc                                                   20


<210> 61
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
agagtccttt gggcttcc                                                     18


<210> 62
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
uaauuucuac uaaguguaga uuuacauggc ucugguccga g                           41


<210> 63
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
aggtgcctgg aatattggtg aacag                                             25


<210> 64
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
tcaagagtgc gggagaaaat tgatcg                                            26


<210> 65
<211> 41
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
uaauuucuac uaaguguaga ucaucagagg cugcucgugu u                           41


<210> 66
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
tttcttgctt tcgtggtatt cttgctagtt acactagcca tccttact                    48


<210> 67
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
tttttttttt tt                                                           12


<210> 68
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
tttttttttt tttttt                                                       16


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
tttttttttt tttttttttt                                                   20


<210> 70
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
tttttttttt tttttttttt tttttttttt                                        30


<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
tttttttttt tttttttttt                                                   20


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
tttttttttt tttttttttt                                                   20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
tttttttttt tttttttttt                                                   20


<210> 74
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
tttttttttt                                                              10


