                         SEQUENCE LISTING

<110>  Corat Therapeutics GmbH
 
<120>  Therapeutic antibodies with neutralizing activity against 
       SARS-CoV-2 Glycoprotein S

<130>  WIPO (to be assigned) 

<140>  PCT Application Number (to be assigned)
<141>  2021-05-19

<150>  EP20178386.7 	
<151>  2020-06-04

<150>  EP20178327.1	
<151>  2020-06-04

<150>  EP20179323.9	
<151>  2020-06-10

<150>  EP20180942.3	
<151>  2020-06-18

<150>  EP20184057.6	
<151>  2020-07-03

<150>  EP20210462.6	
<151>  2020-11-27

<150>  EP20210803.1 	
<151>  2020-11-30 

<160>  1844     

<170>  PatentIn version 3.5

<210>  1
<211>  3822
<212>  DNA
<213>  SARS-CoV-2

<400>  1
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac     3780

tctgagccag tgctcaaagg agtcaaatta cattacacat aa                        3822


<210>  2
<211>  1273
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  3
<211>  2010
<212>  DNA
<213>  SARS-CoV-2

<400>  3
gttaatctta caaccagaac tcaattaccc cctgcataca ctaattcttt cacacgtggt       60

gtttattacc ctgacaaagt tttcagatcc tcagttttac attcaactca ggacttgttc      120

ttacctttct tttccaatgt tacttggttc catgctatac atgtctctgg gaccaatggt      180

actaagaggt ttgataaccc tgtcctacca tttaatgatg gtgtttattt tgcttccact      240

gagaagtcta acataataag aggctggatt tttggtacta ctttagattc gaagacccag      300

tccctactta ttgttaataa cgctactaat gttgttatta aagtctgtga atttcaattt      360

tgtaatgatc catttttggg tgtttattac cacaaaaaca acaaaagttg gatggaaagt      420

gagttcagag tttattctag tgcgaataat tgcacttttg aatatgtctc tcagcctttt      480

cttatggacc ttgaaggaaa acagggtaat ttcaaaaatc ttagggaatt tgtgtttaag      540

aatattgatg gttattttaa aatatattct aagcacacgc ctattaattt agtgcgtgat      600

ctccctcagg gtttttcggc tttagaacca ttggtagatt tgccaatagg tattaacatc      660

actaggtttc aaactttact tgctttacat agaagttatt tgactcctgg tgattcttct      720

tcaggttgga cagctggtgc tgcagcttat tatgtgggtt atcttcaacc taggactttt      780

ctattaaaat ataatgaaaa tggaaccatt acagatgctg tagactgtgc acttgaccct      840

ctctcagaaa caaagtgtac gttgaaatcc ttcactgtag aaaaaggaat ctatcaaact      900

tctaacttta gagtccaacc aacagaatct attgttagat ttcctaatat tacaaacttg      960

tgcccttttg gtgaagtttt taacgccacc agatttgcat ctgtttatgc ttggaacagg     1020

aagagaatca gcaactgtgt tgctgattat tctgtcctat ataattccgc atcattttcc     1080

acttttaagt gttatggagt gtctcctact aaattaaatg atctctgctt tactaatgtc     1140

tatgcagatt catttgtaat tagaggtgat gaagtcagac aaatcgctcc agggcaaact     1200

ggaaagattg ctgattataa ttataaatta ccagatgatt ttacaggctg cgttatagct     1260

tggaattcta acaatcttga ttctaaggtt ggtggtaatt ataattacct gtatagattg     1320

tttaggaagt ctaatctcaa accttttgag agagatattt caactgaaat ctatcaggcc     1380

ggtagcacac cttgtaatgg tgttgaaggt tttaattgtt actttccttt acaatcatat     1440

ggtttccaac ccactaatgg tgttggttac caaccataca gagtagtagt actttctttt     1500

gaacttctac atgcaccagc aactgtttgt ggacctaaaa agtctactaa tttggttaaa     1560

aacaaatgtg tcaatttcaa cttcaatggt ttaacaggca caggtgttct tactgagtct     1620

aacaaaaagt ttctgccttt ccaacaattt ggcagagaca ttgctgacac tactgatgct     1680

gtccgtgatc cacagacact tgagattctt gacattacac catgttcttt tggtggtgtc     1740

agtgttataa caccaggaac aaatacttct aaccaggttg ctgttcttta tcaggatgtt     1800

aactgcacag aagtccctgt tgctattcat gcagatcaac ttactcctac ttggcgtgtt     1860

tattctacag gttctaatgt ttttcaaaca cgtgcaggct gtttaatagg ggctgaacat     1920

gtcaacaact catatgagtg tgacataccc attggtgcag gtatatgcgc tagttatcag     1980

actcagacta attctcctcg gcgggcacgt                                      2010


<210>  4
<211>  670
<212>  PRT
<213>  SARS-CoV-2

<400>  4

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg 
            660                 665                 670 


<210>  5
<211>  669
<212>  DNA
<213>  SARS-CoV-2

<400>  5
agagtccaac caacagaatc tattgttaga tttcctaata ttacaaactt gtgccctttt       60

ggtgaagttt ttaacgccac cagatttgca tctgtttatg cttggaacag gaagagaatc      120

agcaactgtg ttgctgatta ttctgtccta tataattccg catcattttc cacttttaag      180

tgttatggag tgtctcctac taaattaaat gatctctgct ttactaatgt ctatgcagat      240

tcatttgtaa ttagaggtga tgaagtcaga caaatcgctc cagggcaaac tggaaagatt      300

gctgattata attataaatt accagatgat tttacaggct gcgttatagc ttggaattct      360

aacaatcttg attctaaggt tggtggtaat tataattacc tgtatagatt gtttaggaag      420

tctaatctca aaccttttga gagagatatt tcaactgaaa tctatcaggc cggtagcaca      480

ccttgtaatg gtgttgaagg ttttaattgt tactttcctt tacaatcata tggtttccaa      540

cccactaatg gtgttggtta ccaaccatac agagtagtag tactttcttt tgaacttcta      600

catgcaccag caactgtttg tggacctaaa aagtctacta atttggttaa aaacaaatgt      660

gtcaatttc                                                              669


<210>  6
<211>  223
<212>  PRT
<213>  SARS-CoV-2

<400>  6

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  7
<211>  2418
<212>  DNA
<213>  Homo sapiens

<400>  7
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct ccttttag                                                   2418


<210>  8
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 HCDR1 DNA

<400>  9
gacgcctgga tgacc                                                        15



<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 HCDR1 PRT

<400>  10

Asp Ala Trp Met Thr 
1               5   


<210>  11
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 HCDR2 DNA

<400>  11
cgtattaaca gcaacacgga tcatgggaca acagactacg ctgcacccgt gaaaggc          57



<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 HCDR2 PRT

<400>  12

Arg Ile Asn Ser Asn Thr Asp His Gly Thr Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 HCDR3 DNA

<400>  13
tcgtattacg attattggag tgctttcctg tac                                    33



<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 HCDR3 PRT

<400>  14

Ser Tyr Tyr Asp Tyr Trp Ser Ala Phe Leu Tyr 
1               5                   10      


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 LCDR1 DNA

<400>  15
cgggcaagtc agagcattag cagctattta aat                                    33



<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 LCDR1 PRT

<400>  16

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 LCDR2 DNA

<400>  17
gctgcatcca gtttgcaaag t                                                 21



<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 LCDR2 PRT

<400>  18

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  19
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 LCDR3 DNA

<400>  19
caacaggctt acaatatccc gtacact                                           27



<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 LCDR3 PRT

<400>  20

Gln Gln Ala Tyr Asn Ile Pro Tyr Thr 
1               5                   


<210>  21
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VL DNA

<400>  21
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagaatcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg gaacttacta ctgccaacag gcttacaata tcccgtacac ttttggccag      300

gggaccaagg tggaaatcaa a                                                321



<210>  22
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VL PRT

<400>  22

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Ala Tyr Asn Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VH DNA

<400>  23
gaggtgcagc tggtgcagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcctgtgcag cctctggatt ccctttcagt gacgcctgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attaacagca acacggatca tgggacaaca      180

gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacaca      240

ctgtatctgc aaatgaatag cctgaaaacc gaggacacag gcgtttatta ctgtaccttc      300

tcgtattacg attattggag tgctttcctg tactggggtc agggcaccct ggtcaccgtg      360

tcctca                                                                 366



<210>  24
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VH PRT

<400>  24
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Asn Ser Asn Thr Asp His Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Ser Tyr Tyr Asp Tyr Trp Ser Ala Phe Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  25
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VH complete DNA

<400>  25
gaggtgcagc tggtgcagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcctgtgcag cctctggatt ccctttcagt gacgcctgga tgacctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attaacagca acacggatca tgggacaaca      180

gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacaca      240

ctgtatctgc aaatgaatag cctgaaaacc gaggacacag gcgtttatta ctgtaccttc      300

tcgtattacg attattggag tgctttcctg tactggggtc agggcaccct ggtcaccgtg      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tccagtggcc      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtgggcgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa cagctcccat cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaaa gcctctccct gtccccgggt                                      1350



<210>  26
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VH complete PRT

<400>  26
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Asn Ser Asn Thr Asp His Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Ser Tyr Tyr Asp Tyr Trp Ser Ala Phe Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  27
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VL complete DNA

<400>  27
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagaatcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg gaacttacta ctgccaacag gcttacaata tcccgtacac ttttggccag      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  28
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C09 VL complete PRT

<400>  28
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Ala Tyr Asn Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  29
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 HCDR1 DNA

<400>  29
ggctactata tgcac                                                        15



<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 HCDR1 PRT

<400>  30
Gly Tyr Tyr Met His 
1               5   


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 HCDR2 DNA

<400>  31
tggatcaacc ctatcagtgg tggcacaaac tatgcacaga agtttcaagg c                51



<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 HCDR2 PRT

<400>  32
Trp Ile Asn Pro Ile Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  33
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 HCDR3 DNA

<400>  33
gtaccgtatt actatgatag tagtggtctc tggttcgacc cc                          42



<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 HCDR3 PRT

<400>  34
Val Pro Tyr Tyr Tyr Asp Ser Ser Gly Leu Trp Phe Asp Pro 
1               5                   10                  


<210>  35
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 LCDR1 DNA

<400>  35
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42



<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 LCDR1 PRT

<400>  36
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 LCDR2 DNA

<400>  37
gaggtcagta atcggccctc a                                                 21



<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 LCDR2 PRT

<400>  38
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 LCDR3 DNA

<400>  39
agctcatata caagcagcag cacttgggtg                                        30



<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 LCDR3 PRT

<400>  40
Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 
1               5                   10  


<210>  41
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VL DNA

<400>  41
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  42
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VL PRT

<400>  42
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  43
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VH DNA

<400>  43
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta tcagtggtgg cacaaactat      180

gcacagaagt ttcaaggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagtaccg      300

tattactatg atagtagtgg tctctggttc gacccctggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369



<210>  44
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VH PRT

<400>  44
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Tyr Tyr Tyr Asp Ser Ser Gly Leu Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VH complete DNA

<400>  45
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta tcagtggtgg cacaaactat      180

gcacagaagt ttcaaggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagtaccg      300

tattactatg atagtagtgg tctctggttc gacccctggg gccagggaac cctggtcacc      360

gtgtcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctccagtg      720

gccggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtgggc gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaacagctcc catcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga aaagcctctc cctgtccccg ggt                                  1353



<210>  46
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VH complete PRT

<400>  46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ile Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Pro Tyr Tyr Tyr Asp Ser Ser Gly Leu Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  47
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VL complete DNA

<400>  47
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  48
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B05 VL complete PRT

<400>  48
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  49
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 HCDR1 DNA

<400>  49
ggctactata tgcac                                                        15



<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 HCDR1 PRT

<400>  50
Gly Tyr Tyr Met His 
1               5   


<210>  51
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 HCDR2 DNA

<400>  51
tggatcaacc ctaacagtgg tggcacaaac tatgcacaga agtttcaggg c                51



<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 HCDR2 PRT

<400>  52
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  53
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 HCDR3 DNA

<400>  53
gcccccatgt attactatga tagtagtggt tactttgact ac                          42



<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 HCDR3 PRT

<400>  54
Ala Pro Met Tyr Tyr Tyr Asp Ser Ser Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210>  55
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 LCDR1 DNA

<400>  55
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42



<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 LCDR1 PRT

<400>  56
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 LCDR2 DNA

<400>  57
gaggtcagta atcggccctc a                                                 21



<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 LCDR2 PRT

<400>  58
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 LCDR3 DNA

<400>  59
agctcatata caagcagcag cacttatgtc                                        30



<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 LCDR3 PRT

<400>  60
Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val 
1               5                   10  


<210>  61
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VL DNA

<400>  61
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatata caagcagcag cacttatgtc      300

ttcggaactg ggaccaagct gaccgtccta                                       330



<210>  62
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VL PRT

<400>  62
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  63
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VH DNA

<400>  63
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagccccc      300

atgtattact atgatagtag tggttacttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369



<210>  64
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VH PRT

<400>  64
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Met Tyr Tyr Tyr Asp Ser Ser Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  65
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VH complete DNA

<400>  65
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagccccc      300

atgtattact atgatagtag tggttacttt gactactggg gccagggaac cctggtcacc      360

gtgtcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctccagtg      720

gccggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtgggc gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaacagctcc catcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga aaagcctctc cctgtccccg ggt                                  1353



<210>  66
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VH complete PRT

<400>  66
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Met Tyr Tyr Tyr Asp Ser Ser Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  67
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VL complete DNA

<400>  67
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatata caagcagcag cacttatgtc      300

ttcggaactg ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  68
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H01 VL complete PRT

<400>  68
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  69
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 HCDR1 DNA

<400>  69
ggctactata tgcac                                                        15



<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 HCDR1 PRT

<400>  70
Gly Tyr Tyr Met His 
1               5   


<210>  71
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 HCDR2 DNA

<400>  71
tggatcaacc ctaacagtgg tggcacaaac tatgcacaga agtttcaggg c                51



<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 HCDR2 PRT

<400>  72
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  73
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 HCDR3 DNA

<400>  73
ggaccccaat taaatatgat tacgtttggg ggagttggct atgcttttga tatc             54



<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 HCDR3 PRT

<400>  74
Gly Pro Gln Leu Asn Met Ile Thr Phe Gly Gly Val Gly Tyr Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  75
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 LCDR1 DNA

<400>  75
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42



<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 LCDR1 PRT

<400>  76
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 LCDR2 DNA

<400>  77
gatgtcagta atcggccctc a                                                 21



<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 LCDR2 PRT

<400>  78
Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 LCDR3 DNA

<400>  79
agctcatata caagcagcag cactgtggta                                        30



<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 LCDR3 PRT

<400>  80
Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 
1               5                   10  


<210>  81
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VL DNA

<400>  81
cagtctgccc tgactcagcc tgcctccgcg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactgtggta      300

ttcggcggag ggaccaaggt caccgtccta                                       330



<210>  82
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VL PRT

<400>  82
Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  83
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VH DNA

<400>  83
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggctg ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtat tgttggaccc      300

caattaaata tgattacgtt tgggggagtt ggctatgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtgtcttc a                                                381



<210>  84
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VH PRT

<400>  84
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ile Val Gly Pro Gln Leu Asn Met Ile Thr Phe Gly Gly Val Gly Tyr 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  85
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VH complete DNA

<400>  85
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggctg ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtat tgttggaccc      300

caattaaata tgattacgtt tgggggagtt ggctatgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtgtcttc agctagcacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctccag tggccggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg gcgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaacagct cccatccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaaaagcctc tccctgtccc cgggt                     1365



<210>  86
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VH complete PRT

<400>  86
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ile Val Gly Pro Gln Leu Asn Met Ile Thr Phe Gly Gly Val Gly Tyr 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln 
                325                 330                 335     


Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  87
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VL complete DNA

<400>  87
cagtctgccc tgactcagcc tgcctccgcg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactgtggta      300

ttcggcggag ggaccaaggt caccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  88
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F11 VL complete PRT

<400>  88
Gln Ser Ala Leu Thr Gln Pro Ala Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  89
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 HCDR1 DNA

<400>  89
aactatgcca tgagc                                                        15



<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 HCDR1 PRT

<400>  90
Asn Tyr Ala Met Ser 
1               5   


<210>  91
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 HCDR2 DNA

<400>  91
gcttttagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 HCDR2 PRT

<400>  92
Ala Phe Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  93
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 HCDR3 DNA

<400>  93
ggggcccggg gtggctacga ttacggggac tac                                    33



<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 HCDR3 PRT

<400>  94
Gly Ala Arg Gly Gly Tyr Asp Tyr Gly Asp Tyr 
1               5                   10      


<210>  95
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 LCDR1 DNA

<400>  95
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 LCDR1 PRT

<400>  96
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 LCDR2 DNA

<400>  97
gatgcctcca gtttggaaag t                                                 21



<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 LCDR2 PRT

<400>  98
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  99
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 LCDR3 DNA

<400>  99
caacagtata atagttattc tcccacg                                           27



<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 LCDR3 PRT

<400>  100
Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 
1               5                   


<210>  101
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VL DNA

<400>  101
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggttcgatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attctcccac gttcggccaa      300

gggaccaagc tggagatcaa a                                                321



<210>  102
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VL PRT

<400>  102
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Arg Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  103
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VH DNA

<400>  103
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct tttagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggcc      300

cggggtggct acgattacgg ggactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  104
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VH PRT

<400>  104
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Phe Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Arg Gly Gly Tyr Asp Tyr Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  105
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VH complete DNA

<400>  105
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct tttagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggcc      300

cggggtggct acgattacgg ggactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  106
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VH complete PRT

<400>  106
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Phe Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Arg Gly Gly Tyr Asp Tyr Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  107
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VL complete DNA

<400>  107
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggttcgatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attctcccac gttcggccaa      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  108
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C01 VL complete PRT

<400>  108
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Arg Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  109
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 HCDR1 DNA

<400>  109
agctatgcca tgagc                                                        15



<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 HCDR1 PRT

<400>  110
Ser Tyr Ala Met Ser 
1               5   


<210>  111
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 HCDR2 DNA

<400>  111
gctattggtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 HCDR2 PRT

<400>  112
Ala Ile Gly Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  113
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 HCDR3 DNA

<400>  113
ggcccccgct cttccgggga ctactttgac tac                                    33



<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 HCDR3 PRT

<400>  114
Gly Pro Arg Ser Ser Gly Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  115
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 LCDR1 DNA

<400>  115
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 LCDR1 PRT

<400>  116
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 LCDR2 DNA

<400>  117
gatgcctcca gtttggaaag t                                                 21



<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 LCDR2 PRT

<400>  118
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  119
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 LCDR3 DNA

<400>  119
caacagtata atagttattg ggggacg                                           27



<210>  120
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 LCDR3 PRT

<400>  120
Gln Gln Tyr Asn Ser Tyr Trp Gly Thr 
1               5                   


<210>  121
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VL DNA

<400>  121
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attgggggac gttcggccaa      300

gggaccaagg tggagatcaa a                                                321



<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VL PRT

<400>  122
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Trp Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  123
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VH DNA

<400>  123
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attggtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcccc      300

cgctcttccg gggactactt tgactactgg ggccagggaa ccacggtcac cgtgtcctca      360

                                                                       360



<210>  124
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VH PRT

<400>  124
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Ser Gly Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  125
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VH complete DNA

<400>  125
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attggtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcccc      300

cgctcttccg gggactactt tgactactgg ggccagggaa ccacggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  126
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VH complete PRT

<400>  126
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Ser Gly Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  127
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VL complete DNA

<400>  127
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attgggggac gttcggccaa      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  128
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A06 VL complete PRT

<400>  128
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Trp Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  129
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 HCDR1 DNA

<400>  129
agatatgcca tgagc                                                        15



<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 HCDR1 PRT

<400>  130
Arg Tyr Ala Met Ser 
1               5   


<210>  131
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 HCDR2 DNA

<400>  131
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 HCDR2 PRT

<400>  132
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  133
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 HCDR3 DNA

<400>  133
ggaccccgca gtggctggga ctactttgac tac                                    33



<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 HCDR3 PRT

<400>  134
Gly Pro Arg Ser Gly Trp Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  135
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 LCDR1 DNA

<400>  135
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 LCDR1 PRT

<400>  136
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 LCDR2 DNA

<400>  137
gatgcctcca gtttggaaag t                                                 21



<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 LCDR2 PRT

<400>  138
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  139
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 LCDR3 DNA

<400>  139
caacagtata atagttatcc gatgtacact                                        30



<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 LCDR3 PRT

<400>  140
Gln Gln Tyr Asn Ser Tyr Pro Met Tyr Thr 
1               5                   10  


<210>  141
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VL DNA

<400>  141
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt atccgatgta cacttttggc      300

caggggacca agctggagat caaa                                             324



<210>  142
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VL PRT

<400>  142
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  143
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VH DNA

<400>  143
caggtgcagc tggtggagtc tgggggaggc ttggtgcacc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agatatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggaccc      300

cgcagtggct gggactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  144
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VH PRT

<400>  144
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Gly Trp Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  145
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VH complete DNA

<400>  145
caggtgcagc tggtggagtc tgggggaggc ttggtgcacc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agatatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggaccc      300

cgcagtggct gggactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  146
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VH complete PRT

<400>  146
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Gly Trp Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  147
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VL complete DNA

<400>  147
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt atccgatgta cacttttggc      300

caggggacca agctggagat caaacgtacg gtggctgcac catctgtgtt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645



<210>  148
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D12 VL complete PRT

<400>  148
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  149
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 HCDR1 DNA

<400>  149
aattatgctg tcagc                                                        15



<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 HCDR1 PRT

<400>  150
Asn Tyr Ala Val Ser 
1               5   


<210>  151
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 HCDR2 DNA

<400>  151
agaatcatcc ccaatcttgg tcttacaaag tacgcgcaaa acttccaggg c                51



<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 HCDR2 PRT

<400>  152
Arg Ile Ile Pro Asn Leu Gly Leu Thr Lys Tyr Ala Gln Asn Phe Gln 
1               5                   10                  15      



<210>  153
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 HCDR3 DNA

<400>  153
gggttgggcg cttaccccga ttac                                              24



<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 HCDR3 PRT

<400>  154
Gly Leu Gly Ala Tyr Pro Asp Tyr 
1               5               


<210>  155
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 LCDR1 DNA

<400>  155
tctggaagca gctccaacat cggaaataat gctgtaaac                              39



<210>  156
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 LCDR1 PRT

<400>  156
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  157
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 LCDR2 DNA

<400>  157
tatgatgatc tgctgccctc a                                                 21



<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 LCDR2 PRT

<400>  158
Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  159
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 LCDR3 DNA

<400>  159
gcagcatggg atgacagcct gagtggtccg gtg                                    33



<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 LCDR3 PRT

<400>  160
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  161
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VL DNA

<400>  161
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  162
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VL PRT

<400>  162
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  163
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VH DNA

<400>  163
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaagtc       60

tcctgcaagg cttctggagc cacttccacg aattatgctg tcagctgggt gcgacaggcc      120

cctggacaag gacttcaata catgggaaga atcatcccca atcttggtct tacaaagtac      180

gcgcaaaact tccagggcgg ggtcacaatt accgcggaca catccacgag cacagtgtat      240

atggagttgc gcagcctgag atctgaagac acggccgtct attattgtgt gagagggttg      300

ggcgcttacc ccgattactg gggccaggga accctggtca ccgtgtcctc a               351



<210>  164
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VH PRT

<400>  164
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Thr Ser Thr Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Tyr Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Asn Leu Gly Leu Thr Lys Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Gly Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Gly Ala Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  165
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VH complete DNA

<400>  165
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaagtc       60

tcctgcaagg cttctggagc cacttccacg aattatgctg tcagctgggt gcgacaggcc      120

cctggacaag gacttcaata catgggaaga atcatcccca atcttggtct tacaaagtac      180

gcgcaaaact tccagggcgg ggtcacaatt accgcggaca catccacgag cacagtgtat      240

atggagttgc gcagcctgag atctgaagac acggccgtct attattgtgt gagagggttg      300

ggcgcttacc ccgattactg gggccaggga accctggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  166
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VH complete PRT

<400>  166
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Thr Ser Thr Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Tyr Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Asn Leu Gly Leu Thr Lys Tyr Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Gly Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Gly Ala Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  167
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VL complete DNA

<400>  167
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  168
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C09 VL complete PRT

<400>  168
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  169
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 HCDR1 DNA

<400>  169
aactactata tgcac                                                        15



<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 HCDR1 PRT

<400>  170
Asn Tyr Tyr Met His 
1               5   


<210>  171
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 HCDR2 DNA

<400>  171
ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51



<210>  172
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 HCDR2 PRT

<400>  172
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  173
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 HCDR3 DNA

<400>  173
gatctttatg cgatttttgg agtggttatt gac                                    33



<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 HCDR3 PRT

<400>  174
Asp Leu Tyr Ala Ile Phe Gly Val Val Ile Asp 
1               5                   10      


<210>  175
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 LCDR1 DNA

<400>  175
gctggaacca gcagtgacgt tggcggttat aactatgtct ca                          42



<210>  176
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 LCDR1 PRT

<400>  176
Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 LCDR2 DNA

<400>  177
gatgtcacta atcggccctc a                                                 21



<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 LCDR2 PRT

<400>  178
Asp Val Thr Asn Arg Pro Ser 
1               5           


<210>  179
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 LCDR3 DNA

<400>  179
agctcatata caagcagcag cacttgggtg                                        30



<210>  180
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 LCDR3 PRT

<400>  180
Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 
1               5                   10  


<210>  181
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VL DNA

<400>  181
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcgctg gaaccagcag tgacgttggc ggttataact atgtctcatg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ctaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacttgggtg      300

ttcggcggag ggaccaaggt caccgtccta                                       330



<210>  182
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VL PRT

<400>  182
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  183
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VH DNA

<400>  183
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc aactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatctt      300

tatgcgattt ttggagtggt tattgactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  184
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VH PRT

<400>  184
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ala Ile Phe Gly Val Val Ile Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  185
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VH complete DNA

<400>  185
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc aactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatctt      300

tatgcgattt ttggagtggt tattgactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  186
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VH complete PRT

<400>  186
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ala Ile Phe Gly Val Val Ile Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  187
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VL complete DNA

<400>  187
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcgctg gaaccagcag tgacgttggc ggttataact atgtctcatg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ctaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacttgggtg      300

ttcggcggag ggaccaaggt caccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  188
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C12 VL complete PRT

<400>  188
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  189
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 HCDR1 DNA

<400>  189
agcaatgcta tgcat                                                        15



<210>  190
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 HCDR1 PRT

<400>  190
Ser Asn Ala Met His 
1               5   


<210>  191
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 HCDR2 DNA

<400>  191
tggatcaacg ctggcaatgg taacacaaaa tattcacaga agttccaggg c                51



<210>  192
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 HCDR2 PRT

<400>  192
Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      



<210>  193
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 HCDR3 DNA

<400>  193
ggtcgagatg gctacaatgt ggactacttt gaatac                                 36



<210>  194
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 HCDR3 PRT

<400>  194
Gly Arg Asp Gly Tyr Asn Val Asp Tyr Phe Glu Tyr 
1               5                   10          


<210>  195
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 LCDR1 DNA

<400>  195
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  196
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 LCDR1 PRT

<400>  196
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 LCDR2 DNA

<400>  197
gatgcctcca gtttggaaag t                                                 21



<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 LCDR2 PRT

<400>  198
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  199
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 LCDR3 DNA

<400>  199
caacagtata atagttaccc gtggacg                                           27



<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 LCDR3 PRT

<400>  200
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  201
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VL DNA

<400>  201
gacatcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt acccgtggac gttcggccaa      300

gggaccaaag tggatatcaa a                                                321



<210>  202
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VL PRT

<400>  202
Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  203
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VH DNA

<400>  203
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agcaatgcta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaggtcga      300

gatggctaca atgtggacta ctttgaatac tggggccagg gaaccctggt caccgtgtcc      360

tca                                                                    363



<210>  204
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VH PRT

<400>  204
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Asp Gly Tyr Asn Val Asp Tyr Phe Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  205
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VH complete DNA

<400>  205
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agcaatgcta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaggtcga      300

gatggctaca atgtggacta ctttgaatac tggggccagg gaaccctggt caccgtgtcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agtggccgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt gggcgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaacag ctcccatccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaaaagcc tctccctgtc cccgggt                                         1347



<210>  206
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VH complete PRT

<400>  206
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Asp Gly Tyr Asn Val Asp Tyr Phe Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
    


<210>  207
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VL complete DNA

<400>  207
gacatcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt acccgtggac gttcggccaa      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  208
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A02 VL complete PRT

<400>  208
Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  209
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 HCDR1 DNA

<400>  209
agcaatgtta tgcat                                                        15



<210>  210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 HCDR1 PRT

<400>  210
Ser Asn Val Met His 
1               5   


<210>  211
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 HCDR2 DNA

<400>  211
tggatcaacg ctggcaatgg taacacaaaa tattcacaga agttccaggg c                51



<210>  212
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 HCDR2 PRT

<400>  212
Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      



<210>  213
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 HCDR3 DNA

<400>  213
ggtcgagatg gctacaatgt ggactacttt gactac                                 36



<210>  214
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 HCDR3 PRT

<400>  214
Gly Arg Asp Gly Tyr Asn Val Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  215
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 LCDR1 DNA

<400>  215
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  216
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 LCDR1 PRT

<400>  216
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  217
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 LCDR2 DNA

<400>  217
gatgcctcca gtttggaaag t                                                 21



<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 LCDR2 PRT

<400>  218
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  219
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 LCDR3 DNA

<400>  219
caacagtata atagttatcc ctggacg                                           27



<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 LCDR3 PRT

<400>  220
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  221
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VL DNA

<400>  221
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt atccctggac gttcggccaa      300

gggaccaagc tggagatcaa a                                                321



<210>  222
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VL PRT

<400>  222
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  223
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VH DNA

<400>  223
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggct       60

tcctgcaagg cttctggata caccttcact agcaatgtta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaggtcga      300

gatggctaca atgtggacta ctttgactac tggggccagg gaaccctggt caccgtgtcc      360

tca                                                                    363



<210>  224
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VH PRT

<400>  224
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ala Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Asp Gly Tyr Asn Val Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  225
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VH complete DNA

<400>  225
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggct       60

tcctgcaagg cttctggata caccttcact agcaatgtta tgcattgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaggtcga      300

gatggctaca atgtggacta ctttgactac tggggccagg gaaccctggt caccgtgtcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agtggccgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt gggcgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaacag ctcccatccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaaaagcc tctccctgtc cccgggt                                         1347



<210>  226
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VH complete PRT

<400>  226
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ala Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Asp Gly Tyr Asn Val Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
    


<210>  227
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VL complete DNA

<400>  227
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt atccctggac gttcggccaa      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  228
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-E07 VL complete PRT

<400>  228
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  229
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 HCDR1 DNA

<400>  229
agcaactaca tgagc                                                        15



<210>  230
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 HCDR1 PRT

<400>  230
Ser Asn Tyr Met Ser 
1               5   


<210>  231
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 HCDR2 DNA

<400>  231
cttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  232
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 HCDR2 PRT

<400>  232
Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  233
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 HCDR3 DNA

<400>  233
gccctcgagg tcaatacagc tggggactac tttgactac                              39



<210>  234
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 HCDR3 PRT

<400>  234
Ala Leu Glu Val Asn Thr Ala Gly Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  235
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 LCDR1 DNA

<400>  235
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  236
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 LCDR1 PRT

<400>  236
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  237
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 LCDR2 DNA

<400>  237
ggtaacagca atcggccctc a                                                 21



<210>  238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 LCDR2 PRT

<400>  238
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  239
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 LCDR3 DNA

<400>  239
cagtcctatg acagcagcct gagtggttgg gtg                                    33



<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 LCDR3 PRT

<400>  240
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  241
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VL DNA

<400>  241
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttgg      300

gtgttcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  242
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VL PRT

<400>  242
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  243
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VH DNA

<400>  243
gaggtgcagc tggtgcagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgagtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agccctcgag      300

gtcaatacag ctggggacta ctttgactac tggggccagg gaaccctggt caccgtgtcc      360

tca                                                                    363



<210>  244
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VH PRT

<400>  244
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Glu Val Asn Thr Ala Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  245
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VH complete DNA

<400>  245
gaggtgcagc tggtgcagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgagtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agccctcgag      300

gtcaatacag ctggggacta ctttgactac tggggccagg gaaccctggt caccgtgtcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agtggccgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt gggcgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaacag ctcccatccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaaaagcc tctccctgtc cccgggt                                         1347



<210>  246
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VH complete PRT

<400>  246
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Glu Val Asn Thr Ala Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
    


<210>  247
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VL complete DNA

<400>  247
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttgg      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  248
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E12 VL complete PRT

<400>  248
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  249
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 HCDR1 DNA

<400>  249
agcaactaca tgagc                                                        15



<210>  250
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 HCDR1 PRT

<400>  250
Ser Asn Tyr Met Ser 
1               5   


<210>  251
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 HCDR2 DNA

<400>  251
cttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  252
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 HCDR2 PRT

<400>  252
Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  253
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 HCDR3 DNA

<400>  253
gccctcgagg tcaatacagc tggggactac tttgactac                              39



<210>  254
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 HCDR3 PRT

<400>  254
Ala Leu Glu Val Asn Thr Ala Gly Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  255
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 LCDR1 DNA

<400>  255
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  256
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 LCDR1 PRT

<400>  256
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  257
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 LCDR2 DNA

<400>  257
ggtaacagca atcggccctc a                                                 21



<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 LCDR2 PRT

<400>  258
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  259
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 LCDR3 DNA

<400>  259
cagtcctatg acagcagcct gagtggttat gtc                                    33



<210>  260
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 LCDR3 PRT

<400>  260
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  261
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VL DNA

<400>  261
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

gtcttcggaa ctgggaccaa gctgaccgtc cta                                   333



<210>  262
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VL PRT

<400>  262
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  263
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VH DNA

<400>  263
caggtgcagc tggtgcagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgagtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agccctcgag      300

gtcaatacag ctggggacta ctttgactac tggggccagg gaaccctggt caccgtgtcc      360

tca                                                                    363



<210>  264
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VH PRT

<400>  264
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Glu Val Asn Thr Ala Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  265
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VH complete DNA

<400>  265
caggtgcagc tggtgcagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgagtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcactt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agccctcgag      300

gtcaatacag ctggggacta ctttgactac tggggccagg gaaccctggt caccgtgtcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agtggccgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt gggcgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaacag ctcccatccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaaaagcc tctccctgtc cccgggt                                         1347



<210>  266
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VH complete PRT

<400>  266
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Glu Val Asn Thr Ala Gly Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
    


<210>  267
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VL complete DNA

<400>  267
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

gtcttcggaa ctgggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  268
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-E03 VL complete PRT

<400>  268
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  269
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 HCDR1 DNA

<400>  269
agcaactaca tgagc                                                        15



<210>  270
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 HCDR1 PRT

<400>  270
Ser Asn Tyr Met Ser 
1               5   


<210>  271
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 HCDR2 DNA

<400>  271
gttatttata gcggtggtag cacattctac gcagactccg tgaagggc                    48



<210>  272
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 HCDR2 PRT

<400>  272
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  273
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 HCDR3 DNA

<400>  273
gatgggtatt acgatatttt gactggttat tattcagaga attcttttga tatc             54



<210>  274
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 HCDR3 PRT

<400>  274
Asp Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Tyr Ser Glu Asn Ser Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  275
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 LCDR1 DNA

<400>  275
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42



<210>  276
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 LCDR1 PRT

<400>  276
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  277
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 LCDR2 DNA

<400>  277
gaggtcagta atcggccctc a                                                 21



<210>  278
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 LCDR2 PRT

<400>  278
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  279
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 LCDR3 DNA

<400>  279
agctcatata caagcagcag cacttatgtg gta                                    33



<210>  280
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 LCDR3 PRT

<400>  280
Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val Val 
1               5                   10      


<210>  281
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VL DNA

<400>  281
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacttatgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  282
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VL PRT

<400>  282
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  283
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VH DNA

<400>  283
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caactgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatgggtat      300

tacgatattt tgactggtta ttattcagag aattcttttg atatctgggg ccaagggaca      360

atggtcaccg tgtcttca                                                    378



<210>  284
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VH PRT

<400>  284
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Tyr Ser Glu Asn Ser 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210>  285
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VH complete DNA

<400>  285
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caactgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatgggtat      300

tacgatattt tgactggtta ttattcagag aattcttttg atatctgggg ccaagggaca      360

atggtcaccg tgtcttcagc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctccagtgg ccggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtgggcg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aacagctccc atcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa aagcctctcc ctgtccccgg gt                        1362


<210>  286
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VH complete PRT

<400>  286
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Tyr Ser Glu Asn Ser 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  287
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VL complete DNA

<400>  287
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cacttatgtg      300

gtattcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  288
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D06 VL complete PRT

<400>  288
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  289
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 HCDR1 DNA

<400>  289
agcaactaca tgagc                                                        15



<210>  290
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 HCDR1 PRT

<400>  290
Ser Asn Tyr Met Ser 
1               5   


<210>  291
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 HCDR2 DNA

<400>  291
gttatttata gcggtggtag cacattctac gcagactccg tgaagggc                    48



<210>  292
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 HCDR2 PRT

<400>  292
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  293
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 HCDR3 DNA

<400>  293
gacttaggcc cctacggtat ggacgtc                                           27



<210>  294
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 HCDR3 PRT

<400>  294
Asp Leu Gly Pro Tyr Gly Met Asp Val 
1               5                   


<210>  295
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 LCDR1 DNA

<400>  295
cgggccagtc agggcattag cagttattta gcc                                    33



<210>  296
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 LCDR1 PRT

<400>  296
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  297
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 LCDR2 DNA

<400>  297
gctgcatcca ctttgcaaag t                                                 21



<210>  298
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 LCDR2 PRT

<400>  298
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  299
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 LCDR3 DNA

<400>  299
caacagctta atagttaccc tccgtacact                                        30



<210>  300
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 LCDR3 PRT

<400>  300
Gln Gln Leu Asn Ser Tyr Pro Pro Tyr Thr 
1               5                   10  


<210>  301
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VL DNA

<400>  301
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctccgta cacttttggc      300

caggggacca agctggagat caaa                                             324



<210>  302
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VL PRT

<400>  302
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  303
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VH DNA

<400>  303
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctc      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacttaggc      300

ccctacggta tggacgtctg gggccaaggg accctggtca ccgtgtcctc a               351



<210>  304
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VH PRT

<400>  304
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Gly Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  305
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VH complete DNA

<400>  305
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctc      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacttaggc      300

ccctacggta tggacgtctg gggccaaggg accctggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  306
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VH complete PRT

<400>  306
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Gly Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  307
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VL complete DNA

<400>  307
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctccgta cacttttggc      300

caggggacca agctggagat caaacgtacg gtggctgcac catctgtgtt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645



<210>  308
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-E07 VL complete PRT

<400>  308
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  309
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 HCDR1 DNA

<400>  309
agcaactaca tgagc                                                        15



<210>  310
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 HCDR1 PRT

<400>  310
Ser Asn Tyr Met Ser 
1               5   


<210>  311
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 HCDR2 DNA

<400>  311
gttatttata gcggtggtag cacattctac gcagactccg tgaagggc                    48



<210>  312
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 HCDR2 PRT

<400>  312
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  313
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 HCDR3 DNA

<400>  313
gacttaggcc cctacggtat ggacgtc                                           27



<210>  314
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 HCDR3 PRT

<400>  314
Asp Leu Gly Pro Tyr Gly Met Asp Val 
1               5                   


<210>  315
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 LCDR1 DNA

<400>  315
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  316
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 LCDR1 PRT

<400>  316
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  317
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 LCDR2 DNA

<400>  317
ggtagcagca atcggccctc a                                                 21



<210>  318
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 LCDR2 PRT

<400>  318
Gly Ser Ser Asn Arg Pro Ser 
1               5           


<210>  319
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 LCDR3 DNA

<400>  319
gcagcatggg atgacagttt gagtgtcgac gtg                                    33



<210>  320
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 LCDR3 PRT

<400>  320
Ala Ala Trp Asp Asp Ser Leu Ser Val Asp Val 
1               5                   10      


<210>  321
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VL DNA

<400>  321
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtagca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgt gcagcatggg atgacagttt gagtgtcgac      300

gtgttcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  322
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VL PRT

<400>  322
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Val Asp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  323
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VH DNA

<400>  323
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacttaggc      300

ccctacggta tggacgtctg gggccaaggg accctggtca ccgtgtcctc a               351



<210>  324
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VH PRT

<400>  324
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Gly Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  325
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VH complete DNA

<400>  325
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac attctacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacttaggc      300

ccctacggta tggacgtctg gggccaaggg accctggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  326
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VH complete PRT

<400>  326
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Gly Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  327
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VL complete DNA

<400>  327
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtagca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgt gcagcatggg atgacagttt gagtgtcgac      300

gtgttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  328
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B03 VL complete PRT

<400>  328
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Val Asp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  329
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 HCDR1 DNA

<400>  329
agcaactaca tgagc                                                        15



<210>  330
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 HCDR1 PRT

<400>  330
Ser Asn Tyr Met Ser 
1               5   


<210>  331
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 HCDR2 DNA

<400>  331
gttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  332
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 HCDR2 PRT

<400>  332
Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  333
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 HCDR3 DNA

<400>  333
gatttggtta actggggaat ggactac                                           27



<210>  334
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 HCDR3 PRT

<400>  334
Asp Leu Val Asn Trp Gly Met Asp Tyr 
1               5                   


<210>  335
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 LCDR1 DNA

<400>  335
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  336
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 LCDR1 PRT

<400>  336
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  337
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 LCDR2 DNA

<400>  337
ggtaacagca atcggccctc a                                                 21



<210>  338
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 LCDR2 PRT

<400>  338
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  339
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 LCDR3 DNA

<400>  339
cagtcctatg acagcagcct gagtggttat gtc                                    33



<210>  340
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 LCDR3 PRT

<400>  340
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  341
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VL DNA

<400>  341
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

gtcttcggaa ctgggaccaa gctgaccgtc cta                                   333



<210>  342
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VL PRT

<400>  342
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  343
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VH DNA

<400>  343
gaggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggagt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatttggtt      300

aactggggaa tggactactg gggccaggga accctggtca ccgtgtcctc a               351



<210>  344
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VH PRT

<400>  344
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Val Asn Trp Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  345
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VH complete DNA

<400>  345
gaggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggagt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatttggtt      300

aactggggaa tggactactg gggccaggga accctggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  346
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VH complete PRT

<400>  346
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Val Asn Trp Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  347
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VL complete DNA

<400>  347
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

gtcttcggaa ctgggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  348
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D10 VL complete PRT

<400>  348
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  349
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 HCDR1 DNA

<400>  349
agcaactaca tgagc                                                        15



<210>  350
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 HCDR1 PRT

<400>  350
Ser Asn Tyr Met Ser 
1               5   


<210>  351
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 HCDR2 DNA

<400>  351
gttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  352
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 HCDR2 PRT

<400>  352
Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  353
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 HCDR3 DNA

<400>  353
gatcttgttg taatgggcct ggacgtc                                           27



<210>  354
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 HCDR3 PRT

<400>  354
Asp Leu Val Val Met Gly Leu Asp Val 
1               5                   


<210>  355
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 LCDR1 DNA

<400>  355
cgggccagtc agggcattag cagttattta gcc                                    33



<210>  356
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 LCDR1 PRT

<400>  356
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  357
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 LCDR2 DNA

<400>  357
gctgcatcca ctttgcaaag t                                                 21



<210>  358
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 LCDR2 PRT

<400>  358
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  359
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 LCDR3 DNA

<400>  359
caacagctta atagttaccc aatcacc                                           27



<210>  360
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 LCDR3 PRT

<400>  360
Gln Gln Leu Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  361
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VL DNA

<400>  361
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt acccaatcac cttcggccaa      300

gggaccaagc tggagatcaa a                                                321



<210>  362
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VL PRT

<400>  362
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  363
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VH DNA

<400>  363
caggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggact caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt catcatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatcttgtt      300

gtaatgggcc tggacgtctg gggcaaaggg accctggtca ccgtgtcctc a               351



<210>  364
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VH PRT

<400>  364
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Val Val Met Gly Leu Asp Val Trp Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  365
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VH complete DNA

<400>  365
caggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggact caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt catcatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatcttgtt      300

gtaatgggcc tggacgtctg gggcaaaggg accctggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  366
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VH complete PRT

<400>  366
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Val Val Met Gly Leu Asp Val Trp Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  367
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VL complete DNA

<400>  367
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gggcattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt acccaatcac cttcggccaa      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  368
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-D04 VL complete PRT

<400>  368
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  369
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 HCDR1 DNA

<400>  369
agcaactaca tgagc                                                        15



<210>  370
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 HCDR1 PRT

<400>  370
Ser Asn Tyr Met Ser 
1               5   


<210>  371
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 HCDR2 DNA

<400>  371
gttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  372
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 HCDR2 PRT

<400>  372
Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  373
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 HCDR3 DNA

<400>  373
ggggagatac agccatacta ctactacggt atggacgtc                              39



<210>  374
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 HCDR3 PRT

<400>  374
Gly Glu Ile Gln Pro Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  375
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 LCDR1 DNA

<400>  375
actggaacca gcggtgacgt tggtggttat aactatgtct cc                          42



<210>  376
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 LCDR1 PRT

<400>  376
Thr Gly Thr Ser Gly Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  377
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 LCDR2 DNA

<400>  377
gatgtcagta atcggccctc a                                                 21



<210>  378
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 LCDR2 PRT

<400>  378
Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  379
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 LCDR3 DNA

<400>  379
agctcatata caagcagcag cactcctgtg gta                                    33



<210>  380
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 LCDR3 PRT

<400>  380
Ser Ser Tyr Thr Ser Ser Ser Thr Pro Val Val 
1               5                   10      


<210>  381
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VL DNA

<400>  381
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcgg tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactcctgtg      300

gtattcggcg aagggaccaa gctgaccgtc cta                                   333



<210>  382
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VL PRT

<400>  382
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Pro Val Val Phe Gly Glu Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  383
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VH DNA

<400>  383
caggtgcagc tggtgcagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgcgcgag aggggagata      300

cagccatact actactacgg tatggacgtc tggggccaag ggacaatggt caccgtgtct      360

tca                                                                    363



<210>  384
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VH PRT

<400>  384
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Ile Gln Pro Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  385
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VH complete DNA

<400>  385
caggtgcagc tggtgcagtc tgggggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgcgcgag aggggagata      300

cagccatact actactacgg tatggacgtc tggggccaag ggacaatggt caccgtgtct      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agtggccgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt gggcgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaacag ctcccatccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaaaagcc tctccctgtc cccgggt                                         1347



<210>  386
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VH complete PRT

<400>  386
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Ile Gln Pro Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
    


<210>  387
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VL complete DNA

<400>  387
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcgg tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactcctgtg      300

gtattcggcg aagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  388
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-B08 VL complete PRT

<400>  388
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Gly Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Pro Val Val Phe Gly Glu Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  389
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 HCDR1 DNA

<400>  389
agcaactaca tgagc                                                        15



<210>  390
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 HCDR1 PRT

<400>  390
Ser Asn Tyr Met Ser 
1               5   


<210>  391
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 HCDR2 DNA

<400>  391
gttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  392
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 HCDR2 PRT

<400>  392
Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  393
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 HCDR3 DNA

<400>  393
ggagaaagtg ggagcccgta cggtatggac gtc                                    33



<210>  394
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 HCDR3 PRT

<400>  394
Gly Glu Ser Gly Ser Pro Tyr Gly Met Asp Val 
1               5                   10      


<210>  395
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 LCDR1 DNA

<400>  395
tctggaagca gctccaacat tgggaataat tatgtatcc                              39



<210>  396
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 LCDR1 PRT

<400>  396
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  397
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 LCDR2 DNA

<400>  397
gacactaata agcgaccctc g                                                 21



<210>  398
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 LCDR2 PRT

<400>  398
Asp Thr Asn Lys Arg Pro Ser 
1               5           


<210>  399
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 LCDR3 DNA

<400>  399
gcaacatggg atagcagcct gagtgttggg gtg                                    33



<210>  400
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 LCDR3 PRT

<400>  400
Ala Thr Trp Asp Ser Ser Leu Ser Val Gly Val 
1               5                   10      


<210>  401
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VL DNA

<400>  401
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacactaata agcgaccctc ggggattcct      180

gaccgatttt ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgca acatgggata gcagcctgag tgttggggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  402
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VL PRT

<400>  402
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Thr Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  403
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VH DNA

<400>  403
gaggtgcagc tgttggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggct caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacgc gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag aggagaaagt      300

gggagcccgt acggtatgga cgtctggggc caagggaccc tggtcaccgt gtcctca         357



<210>  404
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VH PRT

<400>  404
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Ser Gly Ser Pro Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  405
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VH complete DNA

<400>  405
gaggtgcagc tgttggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggct caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacgc gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag aggagaaagt      300

gggagcccgt acggtatgga cgtctggggc caagggaccc tggtcaccgt gtcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctccagtggc cggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtgggcgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa acagctccca tcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaaa     1320

agcctctccc tgtccccggg t                                               1341



<210>  406
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VH complete PRT

<400>  406
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Glu Ser Gly Ser Pro Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  407
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VL complete DNA

<400>  407
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacactaata agcgaccctc ggggattcct      180

gaccgatttt ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgca acatgggata gcagcctgag tgttggggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  408
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H11 VL complete PRT

<400>  408
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Thr Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  409
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 HCDR1 DNA

<400>  409
agcaactaca tgagc                                                        15



<210>  410
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 HCDR1 PRT

<400>  410
Ser Asn Tyr Met Ser 
1               5   


<210>  411
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 HCDR2 DNA

<400>  411
gttatttata gcggtggtag cacatactac gcagactccg tgaagggc                    48



<210>  412
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 HCDR2 PRT

<400>  412
Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  413
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 HCDR3 DNA

<400>  413
ggcaagagta ttactatggt tcggggagtg ccaactgggg tgcctcccta catggacgtc       60

<210>  414
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 HCDR3 PRT

<400>  414
Gly Lys Ser Ile Thr Met Val Arg Gly Val Pro Thr Gly Val Pro Pro 
1               5                   10                  15      


Tyr Met Asp Val 
            20  


<210>  415
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 LCDR1 DNA

<400>  415
tctggaagca gctccaacat cggaaataat gctgtaaac                              39



<210>  416
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 LCDR1 PRT

<400>  416
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  417
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 LCDR2 DNA

<400>  417
tatgatgatc tgctgccctc a                                                 21



<210>  418
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 LCDR2 PRT

<400>  418
Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  419
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 LCDR3 DNA

<400>  419
gcagcatggg atgacagcct gaatggtgtg gta                                    33



<210>  420
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 LCDR3 PRT

<400>  420
Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  421
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VL DNA

<400>  421
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  422
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VL PRT

<400>  422
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  423
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VH DNA

<400>  423
gaggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggcaagagt      300

attactatgg ttcggggagt gccaactggg gtgcctccct acatggacgt ctggggcaaa      360

gggaccacgg tcaccgtgtc ctca                                             384



<210>  424
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VH PRT

<400>  424
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Lys Ser Ile Thr Met Val Arg Gly Val Pro Thr Gly Val Pro 
            100                 105                 110         


Pro Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  425
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VH complete DNA

<400>  425
gaggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggcaagagt      300

attactatgg ttcggggagt gccaactggg gtgcctccct acatggacgt ctggggcaaa      360

gggaccacgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  426
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VH complete PRT

<400>  426
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Lys Ser Ile Thr Met Val Arg Gly Val Pro Thr Gly Val Pro 
            100                 105                 110         


Pro Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  427
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VL complete DNA

<400>  427
cagtctgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  428
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-A11 VL complete PRT

<400>  428
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  429
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 HCDR1 DNA

<400>  429
agttatgcta tcacc                                                        15



<210>  430
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 HCDR1 PRT

<400>  430
Ser Tyr Ala Ile Thr 
1               5   


<210>  431
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 HCDR2 DNA

<400>  431
gggatcatcc ctatctttgg tacaccaaac tacgcacaga agttccagga c                51



<210>  432
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 HCDR2 PRT

<400>  432
Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  433
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 HCDR3 DNA

<400>  433
gataaagggt tcggggaggg gaaaggttac cactactacg gtctggacgt c                51



<210>  434
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 HCDR3 PRT

<400>  434
Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly Leu Asp 
1               5                   10                  15      



<210>  435
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 LCDR1 DNA

<400>  435
actggaacca gcagtgacgt tggtagttat aactttgtct cc                          42



<210>  436
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 LCDR1 PRT

<400>  436
Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Phe Val Ser 
1               5                   10                  


<210>  437
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 LCDR2 DNA

<400>  437
gaggtcaata atcggccctc a                                                 21



<210>  438
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 LCDR2 PRT

<400>  438
Glu Val Asn Asn Arg Pro Ser 
1               5           


<210>  439
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 LCDR3 DNA

<400>  439
agctcatata caagcagcag cgtggta                                           27



<210>  440
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 LCDR3 PRT

<400>  440
Ser Ser Tyr Thr Ser Ser Ser Val Val 
1               5                   


<210>  441
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VL DNA

<400>  441
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt agttataact ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca ataatcggcc ctcaggggtt      180

tcttatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cgtggtattc      300

ggcggaggga ccaaggtcac cgtccta                                          327



<210>  442
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VL PRT

<400>  442
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Asn Arg Pro Ser Gly Val Ser Tyr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  443
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VH DNA

<400>  443
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcacc agttatgcta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaatgataaa      300

gggttcgggg aggggaaagg ttaccactac tacggtctgg acgtctgggg ccaagggacc      360

ctggtcaccg tgtcctca                                                    378



<210>  444
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VH PRT

<400>  444
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  445
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VH complete DNA

<400>  445
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcacc agttatgcta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaatgataaa      300

gggttcgggg aggggaaagg ttaccactac tacggtctgg acgtctgggg ccaagggacc      360

ctggtcaccg tgtcctcagc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctccagtgg ccggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtgggcg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aacagctccc atcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa aagcctctcc ctgtccccgg gt                        1362



<210>  446
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VH complete PRT

<400>  446
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  447
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VL complete DNA

<400>  447
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt agttataact ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca ataatcggcc ctcaggggtt      180

tcttatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cgtggtattc      300

ggcggaggga ccaaggtcac cgtcctaggt cagcccaagg ctgcaccaag tgtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645



<210>  448
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G06 VL complete PRT

<400>  448
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Asn Arg Pro Ser Gly Val Ser Tyr Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  449
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 HCDR1 DNA

<400>  449
agctatgctc tcacc                                                        15



<210>  450
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 HCDR1 PRT

<400>  450
Ser Tyr Ala Leu Thr 
1               5   


<210>  451
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 HCDR2 DNA

<400>  451
gggatcatcc ctatctttgg tacaccaaac tacgcacaga agttccagga c                51



<210>  452
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 HCDR2 PRT

<400>  452
Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  453
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 HCDR3 DNA

<400>  453
gataaagggt tcggggaggg gaaaggttac cacttctacg gtctggacgt c                51



<210>  454
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 HCDR3 PRT

<400>  454
Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Phe Tyr Gly Leu Asp 
1               5                   10                  15      



<210>  455
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 LCDR1 DNA

<400>  455
actggaacca gcagtgacgt tggtggttat aattttgtct cc                          42



<210>  456
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 LCDR1 PRT

<400>  456
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser 
1               5                   10                  


<210>  457
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 LCDR2 DNA

<400>  457
gaggtcagta atcggccctc a                                                 21



<210>  458
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 LCDR2 PRT

<400>  458
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  459
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 LCDR3 DNA

<400>  459
agctcatata caagcagcgg cagtctcata                                        30



<210>  460
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 LCDR3 PRT

<400>  460
Ser Ser Tyr Thr Ser Ser Gly Ser Leu Ile 
1               5                   10  


<210>  461
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VL DNA

<400>  461
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgtactg gaaccagcag tgacgttggt ggttataatt ttgtctcctg gtatcaacaa      120

tacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctgatcgct tctcgggctc caagtctggc gacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcgg cagtctcata      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  462
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VL PRT

<400>  462
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Gly Ser Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  463
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VH DNA

<400>  463
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgctc tcacctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggccgtgt attactgtgc gaatgataaa      300

gggttcgggg aggggaaagg ttaccacttc tacggtctgg acgtctgggg ccaagggacc      360

acggtcaccg tgtcctca                                                    378



<210>  464
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VH PRT

<400>  464
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Phe Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  465
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VH complete DNA

<400>  465
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgctc tcacctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggccgtgt attactgtgc gaatgataaa      300

gggttcgggg aggggaaagg ttaccacttc tacggtctgg acgtctgggg ccaagggacc      360

acggtcaccg tgtcctcagc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctccagtgg ccggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtgggcg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aacagctccc atcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa aagcctctcc ctgtccccgg gt                        1362



<210>  466
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VH complete PRT

<400>  466
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Phe Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  467
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VL complete DNA

<400>  467
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgtactg gaaccagcag tgacgttggt ggttataatt ttgtctcctg gtatcaacaa      120

tacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctgatcgct tctcgggctc caagtctggc gacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcgg cagtctcata      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  468
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-H02 VL complete PRT

<400>  468
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Gly Ser Leu Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  469
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 HCDR1 DNA

<400>  469
agttatgcta tcacc                                                        15



<210>  470
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 HCDR1 PRT

<400>  470
Ser Tyr Ala Ile Thr 
1               5   


<210>  471
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 HCDR2 DNA

<400>  471
gggatcatcc ctatctttgg tacaccaaac tacgcacaga agttccagga c                51



<210>  472
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 HCDR2 PRT

<400>  472
Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  473
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 HCDR3 DNA

<400>  473
gataaagggt tcggggaggg gaaaggttac cactactacg gtctggacgt c                51



<210>  474
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 HCDR3 PRT

<400>  474
Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly Leu Asp 
1               5                   10                  15      



<210>  475
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 LCDR1 DNA

<400>  475
actggaacca gcagtgatgt tgggagttat aaccttgtct cc                          42



<210>  476
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 LCDR1 PRT

<400>  476
Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  477
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 LCDR2 DNA

<400>  477
gaggtcagta agcggccctc a                                                 21



<210>  478
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 LCDR2 PRT

<400>  478
Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  479
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 LCDR3 DNA

<400>  479
agctcatatg caggcagcaa caatgtggta                                        30



<210>  480
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 LCDR3 PRT

<400>  480
Ser Ser Tyr Ala Gly Ser Asn Asn Val Val 
1               5                   10  


<210>  481
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VL DNA

<400>  481
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa caatgtggta      300

ttcggcggag gcacccagct gaccgtcctc                                       330



<210>  482
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VL PRT

<400>  482
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  483
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VH DNA

<400>  483
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcacc agttatgcta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaatgataaa      300

gggttcgggg aggggaaagg ttaccactac tacggtctgg acgtctgggg ccaagggacc      360

ctggtcaccg tgtcctca                                                    378



<210>  484
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VH PRT

<400>  484
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  485
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VH complete DNA

<400>  485
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcacc agttatgcta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaatgataaa      300

gggttcgggg aggggaaagg ttaccactac tacggtctgg acgtctgggg ccaagggacc      360

ctggtcaccg tgtcctcagc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctccagtgg ccggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtgggcg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aacagctccc atcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa aagcctctcc ctgtccccgg gt                        1362



<210>  486
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VH complete PRT

<400>  486
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Phe Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  487
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VL complete DNA

<400>  487
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc      240

caggctgagg atgaggctga ttattactgc agctcatatg caggcagcaa caatgtggta      300

ttcggcggag gcacccagct gaccgtcctc ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  488
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-F06 VL complete PRT

<400>  488
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  489
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 HCDR1 DNA

<400>  489
agctatgcta tcagc                                                        15



<210>  490
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 HCDR1 PRT

<400>  490
Ser Tyr Ala Ile Ser 
1               5   


<210>  491
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 HCDR2 DNA

<400>  491
tggatcaacc ctaacagtgg tggcacaaac tatgcacaga agtttcaggg c                51



<210>  492
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 HCDR2 PRT

<400>  492
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  493
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 HCDR3 DNA

<400>  493
ggaccactac cgtataactg gaactacgaa ggacactggt tcgacccc                    48



<210>  494
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 HCDR3 PRT

<400>  494
Gly Pro Leu Pro Tyr Asn Trp Asn Tyr Glu Gly His Trp Phe Asp Pro 
1               5                   10                  15      


<210>  495
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 LCDR1 DNA

<400>  495
tctggaagca gctccaacat tgggaataat tatgtatcc                              39



<210>  496
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 LCDR1 PRT

<400>  496
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  497
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 LCDR2 DNA

<400>  497
ggtaacagca atcggccctc a                                                 21



<210>  498
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 LCDR2 PRT

<400>  498
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  499
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 LCDR3 DNA

<400>  499
cagtcctatg acagcagcct gagtggttcg gta                                    33



<210>  500
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 LCDR3 PRT

<400>  500
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  501
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VL DNA

<400>  501
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag      240

gctgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tggttcggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  502
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VL PRT

<400>  502
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  503
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VH DNA

<400>  503
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagaggacca      300

ctaccgtata actggaacta cgaaggacac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtgt cctca                                                       375



<210>  504
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VH PRT

<400>  504
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Leu Pro Tyr Asn Trp Asn Tyr Glu Gly His Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  505
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VH complete DNA

<400>  505
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagaggacca      300

ctaccgtata actggaacta cgaaggacac tggttcgacc cctggggcca gggaaccctg      360

gtcaccgtgt cctcagctag caccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagaaagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

ccagtggccg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtgggcgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtaca acagcacgta ccgggtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaac agctcccatc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaaaag cctctccctg tccccgggt                            1359



<210>  506
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VH complete PRT

<400>  506
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Leu Pro Tyr Asn Trp Asn Tyr Glu Gly His Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210>  507
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VL complete DNA

<400>  507
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcac tgggctccag      240

gctgaggatg aggctgatta ttactgccag tcctatgaca gcagcctgag tggttcggta      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  508
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C05 VL complete PRT

<400>  508
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  509
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 HCDR1 DNA

<400>  509
agttatgcta tcacc                                                        15



<210>  510
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 HCDR1 PRT

<400>  510
Ser Tyr Ala Ile Thr 
1               5   


<210>  511
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 HCDR2 DNA

<400>  511
gggatcatcc ctatctttgg tacaccaaac tacgcacaga agttccagga c                51



<210>  512
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 HCDR2 PRT

<400>  512
Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  513
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 HCDR3 DNA

<400>  513
gataaagggc tcggggaggg gaaaggttac cactactacg gtctggacgt c                51



<210>  514
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 HCDR3 PRT

<400>  514
Asp Lys Gly Leu Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly Leu Asp 
1               5                   10                  15      



<210>  515
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 LCDR1 DNA

<400>  515
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42



<210>  516
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 LCDR1 PRT

<400>  516
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  517
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 LCDR2 DNA

<400>  517
gaggtcagta atcggccctc a                                                 21



<210>  518
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 LCDR2 PRT

<400>  518
Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  519
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 LCDR3 DNA

<400>  519
acctcatata caagtaacag caatctcgcc                                        30



<210>  520
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 LCDR3 PRT

<400>  520
Thr Ser Tyr Thr Ser Asn Ser Asn Leu Ala 
1               5                   10  


<210>  521
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VL DNA

<400>  521
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc acctcatata caagtaacag caatctcgcc      300

ttcggatctg ggaccaagct gaccgtccta                                       330



<210>  522
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VL PRT

<400>  522
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Thr Ser Asn 
                85                  90                  95      


Ser Asn Leu Ala Phe Gly Ser Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  523
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VH DNA

<400>  523
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatgcta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaatgataaa      300

gggctcgggg aggggaaagg ttaccactac tacggtctgg acgtctgggg ccaagggacc      360

ctggtcaccg tgtcctca                                                    378



<210>  524
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VH PRT

<400>  524
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Leu Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  525
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VH complete DNA

<400>  525
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatgcta tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac accaaactac      180

gcacagaagt tccaggacag agtcacgatt accgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaatgataaa      300

gggctcgggg aggggaaagg ttaccactac tacggtctgg acgtctgggg ccaagggacc      360

ctggtcaccg tgtcctcagc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagaaag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctccagtgg ccggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtgggcg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aacagctccc atcccccatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa aagcctctcc ctgtccccgg gt                        1362



<210>  526
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VH complete PRT

<400>  526
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Asp Lys Gly Leu Gly Glu Gly Lys Gly Tyr His Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  527
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VL complete DNA

<400>  527
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc acctcatata caagtaacag caatctcgcc      300

ttcggatctg ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  528
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D09 VL complete PRT

<400>  528
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Thr Ser Asn 
                85                  90                  95      


Ser Asn Leu Ala Phe Gly Ser Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  529
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 HCDR1 DNA

<400>  529
agctatgcta tgcat                                                        15



<210>  530
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 HCDR1 PRT

<400>  530
Ser Tyr Ala Met His 
1               5   


<210>  531
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 HCDR2 DNA

<400>  531
tggatcaacg ctggcaatgg taacacaaaa tattcacaga agttccaggg c                51



<210>  532
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 HCDR2 PRT

<400>  532
Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      



<210>  533
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 HCDR3 DNA

<400>  533
tcgttcgatt cggggagtta ttataacgta gatgcttttg atatc                       45



<210>  534
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 HCDR3 PRT

<400>  534
Ser Phe Asp Ser Gly Ser Tyr Tyr Asn Val Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  535
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 LCDR1 DNA

<400>  535
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  536
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 LCDR1 PRT

<400>  536
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  537
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 LCDR2 DNA

<400>  537
gatgcctcca gtttggaaag t                                                 21



<210>  538
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 LCDR2 PRT

<400>  538
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  539
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 LCDR3 DNA

<400>  539
caacagtata atagttattc gtggacg                                           27



<210>  540
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 LCDR3 PRT

<400>  540
Gln Gln Tyr Asn Ser Tyr Ser Trp Thr 
1               5                   


<210>  541
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VL DNA

<400>  541
gacatcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attcgtggac gttcggccaa      300

gggaccaagg tggagatcaa a                                                321



<210>  542
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VL PRT

<400>  542
Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  543
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VH DNA

<400>  543
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgcattgggt gcgccaggcc      120

cccggacaaa ggcctgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagatcgttc      300

gattcgggga gttattataa cgtagatgct tttgatatct ggggccaagg gacaatggtc      360

accgtgtctt ca                                                          372



<210>  544
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VH PRT

<400>  544
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Asp Ser Gly Ser Tyr Tyr Asn Val Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  545
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VH complete DNA

<400>  545
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatgcta tgcattgggt gcgccaggcc      120

cccggacaaa ggcctgagtg gatgggatgg atcaacgctg gcaatggtaa cacaaaatat      180

tcacagaagt tccagggcag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagatcgttc      300

gattcgggga gttattataa cgtagatgct tttgatatct ggggccaagg gacaatggtc      360

accgtgtctt cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctcca      720

gtggccggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg ggcgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaacagc tcccatcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaaaagcct ctccctgtcc ccgggt                               1356



<210>  546
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VH complete PRT

<400>  546
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Asp Ser Gly Ser Tyr Tyr Asn Val Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
225                 230                 235                 240 


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  547
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VL complete DNA

<400>  547
gacatcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attcgtggac gttcggccaa      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  548
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-C06 VL complete PRT

<400>  548
Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  549
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 HCDR1 DNA

<400>  549
agctatgcca tgagc                                                        15



<210>  550
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 HCDR1 PRT

<400>  550
Ser Tyr Ala Met Ser 
1               5   


<210>  551
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 HCDR2 DNA

<400>  551
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  552
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 HCDR2 PRT

<400>  552
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  553
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 HCDR3 DNA

<400>  553
ggtccgaggg ggtctgctga ctacgttgac tac                                    33



<210>  554
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 HCDR3 PRT

<400>  554
Gly Pro Arg Gly Ser Ala Asp Tyr Val Asp Tyr 
1               5                   10      


<210>  555
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 LCDR1 DNA

<400>  555
cgggccagtc acagtattag tagctggttg gcc                                    33



<210>  556
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 LCDR1 PRT

<400>  556
Arg Ala Ser His Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  557
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 LCDR2 DNA

<400>  557
gatgcctcca gtttggaaag t                                                 21



<210>  558
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 LCDR2 PRT

<400>  558
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  559
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 LCDR3 DNA

<400>  559
caacagtata atacttattc agggacg                                           27



<210>  560
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 LCDR3 PRT

<400>  560
Gln Gln Tyr Asn Thr Tyr Ser Gly Thr 
1               5                   


<210>  561
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VL DNA

<400>  561
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca cagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctcagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatactt attcagggac gttcggccaa      300

gggaccaaag tggatatcaa a                                                321



<210>  562
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VL PRT

<400>  562
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  563
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VH DNA

<400>  563
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtccg      300

agggggtctg ctgactacgt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  564
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VH PRT

<400>  564
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Gly Ser Ala Asp Tyr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  565
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VH complete DNA

<400>  565
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtccg      300

agggggtctg ctgactacgt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  566
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VH complete PRT

<400>  566
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Gly Ser Ala Asp Tyr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  567
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VL complete DNA

<400>  567
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca cagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctcagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatactt attcagggac gttcggccaa      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  568
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-A09 VL complete PRT

<400>  568
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Ser Gly 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  569
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 HCDR1 DNA

<400>  569
agctatgcca tgagc                                                        15



<210>  570
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 HCDR1 PRT

<400>  570
Ser Tyr Ala Met Ser 
1               5   


<210>  571
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 HCDR2 DNA

<400>  571
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  572
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 HCDR2 PRT

<400>  572
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  573
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 HCDR3 DNA

<400>  573
ggtccgaggg ggtctgctga ctacgttgac tac                                    33



<210>  574
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 HCDR3 PRT

<400>  574
Gly Pro Arg Gly Ser Ala Asp Tyr Val Asp Tyr 
1               5                   10      


<210>  575
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 LCDR1 DNA

<400>  575
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  576
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 LCDR1 PRT

<400>  576
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  577
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 LCDR2 DNA

<400>  577
gatgcctcca gtttggaaag t                                                 21



<210>  578
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 LCDR2 PRT

<400>  578
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  579
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 LCDR3 DNA

<400>  579
caacagtata atagttattc gtacact                                           27



<210>  580
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 LCDR3 PRT

<400>  580
Gln Gln Tyr Asn Ser Tyr Ser Tyr Thr 
1               5                   


<210>  581
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VL DNA

<400>  581
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attcgtacac ttttggccag      300

gggacacgac tggagattaa a                                                321



<210>  582
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VL PRT

<400>  582
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  583
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VH DNA

<400>  583
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtccg      300

agggggtctg ctgactacgt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  584
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VH PRT

<400>  584
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Gly Ser Ala Asp Tyr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  585
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VH complete DNA

<400>  585
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtccg      300

agggggtctg ctgactacgt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  586
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VH complete PRT

<400>  586
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Gly Ser Ala Asp Tyr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  587
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VL complete DNA

<400>  587
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attcgtacac ttttggccag      300

gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  588
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G09 VL complete PRT

<400>  588
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  589
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 HCDR1 DNA

<400>  589
agctatgcca tgagc                                                        15



<210>  590
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 HCDR1 PRT

<400>  590
Ser Tyr Ala Met Ser 
1               5   


<210>  591
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 HCDR2 DNA

<400>  591
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  592
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 HCDR2 PRT

<400>  592
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  593
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 HCDR3 DNA

<400>  593
ggggtccgat ataactccga ctactttgac tac                                    33



<210>  594
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 HCDR3 PRT

<400>  594
Gly Val Arg Tyr Asn Ser Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  595
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 LCDR1 DNA

<400>  595
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  596
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 LCDR1 PRT

<400>  596
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  597
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 LCDR2 DNA

<400>  597
gatgcctcca gtttggaaag t                                                 21



<210>  598
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 LCDR2 PRT

<400>  598
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  599
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 LCDR3 DNA

<400>  599
caacagtata atagtgttct cggggtcact                                        30



<210>  600
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 LCDR3 PRT

<400>  600
Gln Gln Tyr Asn Ser Val Leu Gly Val Thr 
1               5                   10  


<210>  601
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VL DNA

<400>  601
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtg ttctcggggt cactttcggc      300

ggagggacca agctggagat caaa                                             324



<210>  602
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VL PRT

<400>  602
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Val Leu Gly 
                85                  90                  95      


Val Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  603
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VH DNA

<400>  603
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggtc      300

cgatataact ccgactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  604
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VH PRT

<400>  604
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Arg Tyr Asn Ser Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  605
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VH complete DNA

<400>  605
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggtc      300

cgatataact ccgactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  606
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VH complete PRT

<400>  606
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Arg Tyr Asn Ser Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  607
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VL complete DNA

<400>  607
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtg ttctcggggt cactttcggc      300

ggagggacca agctggagat caaacgtacg gtggctgcac catctgtgtt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645



<210>  608
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H01 VL complete PRT

<400>  608
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Val Leu Gly 
                85                  90                  95      


Val Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  609
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 HCDR1 DNA

<400>  609
agctatgcca tgagc                                                        15



<210>  610
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 HCDR1 PRT

<400>  610
Ser Tyr Ala Met Ser 
1               5   


<210>  611
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 HCDR2 DNA

<400>  611
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  612
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 HCDR2 PRT

<400>  612
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  613
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 HCDR3 DNA

<400>  613
ggggtcagat actcatcaga ctattttgag tac                                    33



<210>  614
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 HCDR3 PRT

<400>  614
Gly Val Arg Tyr Ser Ser Asp Tyr Phe Glu Tyr 
1               5                   10      


<210>  615
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 LCDR1 DNA

<400>  615
cgggccagtc agagtattag tagctggttg gcc                                    33



<210>  616
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 LCDR1 PRT

<400>  616
Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  617
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 LCDR2 DNA

<400>  617
gatgcctcca gtttggaaag t                                                 21



<210>  618
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 LCDR2 PRT

<400>  618
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  619
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 LCDR3 DNA

<400>  619
caacagtatg agacttattc tcagacg                                           27



<210>  620
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 LCDR3 PRT

<400>  620
Gln Gln Tyr Glu Thr Tyr Ser Gln Thr 
1               5                   


<210>  621
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VL DNA

<400>  621
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagtct      240

gatgattttg caacttatta ctgtcaacag tatgagactt attctcagac gttcggccaa      300

gggaccaagc tggagatcaa a                                                321



<210>  622
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VL PRT

<400>  622
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Thr Tyr Ser Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  623
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VH DNA

<400>  623
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggtc      300

agatactcat cagactattt tgagtactgg ggccagggaa ccacggtcac cgtgtcctca      360

                                                                       360



<210>  624
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VH PRT

<400>  624
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Arg Tyr Ser Ser Asp Tyr Phe Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  625
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VH complete DNA

<400>  625
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggggtc      300

agatactcat cagactattt tgagtactgg ggccagggaa ccacggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  626
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VH complete PRT

<400>  626
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Val Arg Tyr Ser Ser Asp Tyr Phe Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  627
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VL complete DNA

<400>  627
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagtct      240

gatgattttg caacttatta ctgtcaacag tatgagactt attctcagac gttcggccaa      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  628
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-H05 VL complete PRT

<400>  628
Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Thr Tyr Ser Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  629
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 HCDR1 DNA

<400>  629
agctatgcca tgagc                                                        15



<210>  630
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 HCDR1 PRT

<400>  630
Ser Tyr Ala Met Ser 
1               5   


<210>  631
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 HCDR2 DNA

<400>  631
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  632
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 HCDR2 PRT

<400>  632
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  633
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 HCDR3 DNA

<400>  633
ggtccccgta gtggtactga ctactttgac tac                                    33



<210>  634
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 HCDR3 PRT

<400>  634
Gly Pro Arg Ser Gly Thr Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  635
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 LCDR1 DNA

<400>  635
cgggccagtg agagtattcg gagctggttg gcc                                    33



<210>  636
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 LCDR1 PRT

<400>  636
Arg Ala Ser Glu Ser Ile Arg Ser Trp Leu Ala 
1               5                   10      


<210>  637
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 LCDR2 DNA

<400>  637
gatgcctcca atttggaaag t                                                 21



<210>  638
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 LCDR2 PRT

<400>  638
Asp Ala Ser Asn Leu Glu Ser 
1               5           


<210>  639
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 LCDR3 DNA

<400>  639
caacagtatt atagttatcc gctcact                                           27



<210>  640
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 LCDR3 PRT

<400>  640
Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  641
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VL DNA

<400>  641
gacatccaga tgacccagtc tccttccatc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtga gagtattcgg agctggttgg cctggtatca gcagaaggca      120

gggaaagccc ctaacctcct aatctatgat gcctccaatt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggtcagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tattatagtt atccgctcac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321



<210>  642
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VL PRT

<400>  642
Asp Ile Gln Met Thr Gln Ser Pro Ser Ile Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  643
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VH DNA

<400>  643
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtccc      300

cgtagtggta ctgactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  644
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VH PRT

<400>  644
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Gly Thr Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  645
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VH complete DNA

<400>  645
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggtccc      300

cgtagtggta ctgactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  646
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VH complete PRT

<400>  646
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Gly Thr Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  647
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VL complete DNA

<400>  647
gacatccaga tgacccagtc tccttccatc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtga gagtattcgg agctggttgg cctggtatca gcagaaggca      120

gggaaagccc ctaacctcct aatctatgat gcctccaatt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggtcagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tattatagtt atccgctcac tttcggcgga      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  648
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G02 VL complete PRT

<400>  648
Asp Ile Gln Met Thr Gln Ser Pro Ser Ile Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  649
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 HCDR1 DNA

<400>  649
agctatgcca tgagc                                                        15



<210>  650
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 HCDR1 PRT

<400>  650
Ser Tyr Ala Met Ser 
1               5   


<210>  651
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 HCDR2 DNA

<400>  651
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  652
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 HCDR2 PRT

<400>  652
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  653
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 HCDR3 DNA

<400>  653
ggaccgagaa gtggctacga ctatggggac tac                                    33



<210>  654
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 HCDR3 PRT

<400>  654
Gly Pro Arg Ser Gly Tyr Asp Tyr Gly Asp Tyr 
1               5                   10      


<210>  655
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 LCDR1 DNA

<400>  655
cgggcgagtc agggtattag cagctggtta gcc                                    33



<210>  656
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 LCDR1 PRT

<400>  656
Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  657
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 LCDR2 DNA

<400>  657
gatgcctcca gtttggaaag t                                                 21



<210>  658
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 LCDR2 PRT

<400>  658
Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  659
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 LCDR3 DNA

<400>  659
caacagttta atagttaccc tctcact                                           27



<210>  660
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 LCDR3 PRT

<400>  660
Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  661
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VL DNA

<400>  661
gacatccagt tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatcg      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300

gggaccaagg tggaaatcaa a                                                321



<210>  662
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VL PRT

<400>  662
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  663
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VH DNA

<400>  663
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggaccg      300

agaagtggct acgactatgg ggactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  664
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VH PRT

<400>  664
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Gly Tyr Asp Tyr Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  665
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VH complete DNA

<400>  665
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggaccg      300

agaagtggct acgactatgg ggactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  666
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VH complete PRT

<400>  666
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Arg Ser Gly Tyr Asp Tyr Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  667
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VL complete DNA

<400>  667
gacatccagt tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatcg      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  668
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-G11 VL complete PRT

<400>  668
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  669
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 HCDR1 DNA

<400>  669
agctatgcca tgagc                                                        15



<210>  670
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 HCDR1 PRT

<400>  670
Ser Tyr Ala Met Ser 
1               5   


<210>  671
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 HCDR2 DNA

<400>  671
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  672
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 HCDR2 PRT

<400>  672
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  673
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 HCDR3 DNA

<400>  673
tcggtgggtt actatgatag tagtggttat tatcactttg gggactactt tgactac          57



<210>  674
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 HCDR3 PRT

<400>  674
Ser Val Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Phe Gly Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  675
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 LCDR1 DNA

<400>  675
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  676
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 LCDR1 PRT

<400>  676
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  677
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 LCDR2 DNA

<400>  677
ggtaacagca atcggccctc a                                                 21



<210>  678
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 LCDR2 PRT

<400>  678
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  679
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 LCDR3 DNA

<400>  679
cagtcctatg acagcagcct gagtggttcg gta                                    33



<210>  680
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 LCDR3 PRT

<400>  680
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  681
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VL DNA

<400>  681
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  682
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VL PRT

<400>  682
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  683
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VH DNA

<400>  683
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc ccgctcggtg      300

ggttactatg atagtagtgg ttattatcac tttggggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  684
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VH PRT

<400>  684
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Phe Gly 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  685
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VH complete DNA

<400>  685
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc ccgctcggtg      300

ggttactatg atagtagtgg ttattatcac tttggggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  686
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VH complete PRT

<400>  686
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Phe Gly 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  687
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VL complete DNA

<400>  687
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

gtattcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  688
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-B11 VL complete PRT

<400>  688
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  689
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 HCDR1 DNA

<400>  689
agctatgcca tgagc                                                        15



<210>  690
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 HCDR1 PRT

<400>  690
Ser Tyr Ala Met Ser 
1               5   


<210>  691
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 HCDR2 DNA

<400>  691
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  692
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 HCDR2 PRT

<400>  692
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  693
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 HCDR3 DNA

<400>  693
tcggtgggtt actatgatag tagtggttat tatcactttg gggactactt tgactac          57



<210>  694
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 HCDR3 PRT

<400>  694
Ser Val Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Phe Gly Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  695
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 LCDR1 DNA

<400>  695
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  696
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 LCDR1 PRT

<400>  696
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  697
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 LCDR2 DNA

<400>  697
ggtaacagca atcggccctc a                                                 21



<210>  698
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 LCDR2 PRT

<400>  698
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  699
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 LCDR3 DNA

<400>  699
cagtcctatg acagcagcct gagtggagtg gta                                    33



<210>  700
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 LCDR3 PRT

<400>  700
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  701
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VL DNA

<400>  701
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggagtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  702
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VL PRT

<400>  702
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  703
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VH DNA

<400>  703
caggttcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc ccgctcggtg      300

ggttactatg atagtagtgg ttattatcac tttggggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  704
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VH PRT

<400>  704
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Phe Gly 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  705
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VH complete DNA

<400>  705
caggttcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc ccgctcggtg      300

ggttactatg atagtagtgg ttattatcac tttggggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  706
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VH complete PRT

<400>  706
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Gly Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Phe Gly 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  707
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VL complete DNA

<400>  707
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggagtg      300

gtattcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  708
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C10 VL complete PRT

<400>  708
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  709
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 HCDR1 DNA

<400>  709
agctactgga tcggc                                                        15



<210>  710
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 HCDR1 PRT

<400>  710
Ser Tyr Trp Ile Gly 
1               5   


<210>  711
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 HCDR2 DNA

<400>  711
atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg c                51



<210>  712
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 HCDR2 PRT

<400>  712
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      



<210>  713
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 HCDR3 DNA

<400>  713
caaaattact atgatagtag tggttattac tactttgact ac                          42



<210>  714
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 HCDR3 PRT

<400>  714
Gln Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  715
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 LCDR1 DNA

<400>  715
cgggcaagtc agagcattag cagctattta aat                                    33



<210>  716
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 LCDR1 PRT

<400>  716
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  717
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 LCDR2 DNA

<400>  717
gctgcatcca gtttgcaaag t                                                 21



<210>  718
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 LCDR2 PRT

<400>  718
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  719
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 LCDR3 DNA

<400>  719
caacagagtt acagtaccca ttcgtggacg                                        30



<210>  720
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 LCDR3 PRT

<400>  720
Gln Gln Ser Tyr Ser Thr His Ser Trp Thr 
1               5                   10  


<210>  721
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VL DNA

<400>  721
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccattcgtg gacgttcggc      300

caagggacca aagtggatat caaa                                             324



<210>  722
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VL PRT

<400>  722
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr His Ser 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  723
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VH DNA

<400>  723
caggttcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagccaaaat      300

tactatgata gtagtggtta ttactacttt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369



<210>  724
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VH PRT

<400>  724
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  725
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VH complete DNA

<400>  725
caggttcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagccaaaat      300

tactatgata gtagtggtta ttactacttt gactactggg gccagggaac cctggtcacc      360

gtgtcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctccagtg      720

gccggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtgggc gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaacagctcc catcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga aaagcctctc cctgtccccg ggt                                  1353



<210>  726
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VH complete PRT

<400>  726
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gln Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  727
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VL complete DNA

<400>  727
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccattcgtg gacgttcggc      300

caagggacca aagtggatat caaacgtacg gtggctgcac catctgtgtt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645



<210>  728
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-D10 VL complete PRT

<400>  728
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr His Ser 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  729
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 HCDR1 DNA

<400>  729
agctactgga tcggc                                                        15



<210>  730
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 HCDR1 PRT

<400>  730
Ser Tyr Trp Ile Gly 
1               5   


<210>  731
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 HCDR2 DNA

<400>  731
atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg c                51



<210>  732
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 HCDR2 PRT

<400>  732
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      



<210>  733
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 HCDR3 DNA

<400>  733
agtcggagta gtgactactt tgactac                                           27



<210>  734
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 HCDR3 PRT

<400>  734
Ser Arg Ser Ser Asp Tyr Phe Asp Tyr 
1               5                   


<210>  735
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 LCDR1 DNA

<400>  735
cgggcgagtc agggtattag cagctggtta gcc                                    33



<210>  736
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 LCDR1 PRT

<400>  736
Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  737
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 LCDR2 DNA

<400>  737
gatgcatcca atttggaaac a                                                 21



<210>  738
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 LCDR2 PRT

<400>  738
Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  739
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 LCDR3 DNA

<400>  739
caacagtatg ataatctccc tgtcact                                           27



<210>  740
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 LCDR3 PRT

<400>  740
Gln Gln Tyr Asp Asn Leu Pro Val Thr 
1               5                   


<210>  741
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VL DNA

<400>  741
gacatccagt tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccctgtcac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321



<210>  742
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VL PRT

<400>  742
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  743
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VH DNA

<400>  743
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagaagtcgg      300

agtagtgact actttgacta ctggggccag ggaaccacgg tcaccgtgtc ctca            354



<210>  744
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VH PRT

<400>  744
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Ser Ser Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  745
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VH complete DNA

<400>  745
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagaagtcgg      300

agtagtgact actttgacta ctggggccag ggaaccacgg tcaccgtgtc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctc cagtggccgg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tgggcgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaaca gctcccatcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaaaagc     1320

ctctccctgt ccccgggt                                                   1338



<210>  746
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VH complete PRT

<400>  746
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Ser Ser Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  747
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VL complete DNA

<400>  747
gacatccagt tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccctgtcac tttcggcgga      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  748
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU535-B02 VL complete PRT

<400>  748
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  749
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 HCDR1 DNA

<400>  749
agctactgga tcggc                                                        15



<210>  750
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 HCDR1 PRT

<400>  750
Ser Tyr Trp Ile Gly 
1               5   


<210>  751
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 HCDR2 DNA

<400>  751
atcatctatc ctggtgactc tgataccaga tacagcccgt ccttccaagg c                51



<210>  752
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 HCDR2 PRT

<400>  752
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      



<210>  753
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 HCDR3 DNA

<400>  753
tataacagtg gctggcttga ctac                                              24



<210>  754
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 HCDR3 PRT

<400>  754
Tyr Asn Ser Gly Trp Leu Asp Tyr 
1               5               


<210>  755
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 LCDR1 DNA

<400>  755
tctggaagca gctccaacat cggaagtaat cctgtaaac                              39



<210>  756
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 LCDR1 PRT

<400>  756
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Pro Val Asn 
1               5                   10              


<210>  757
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 LCDR2 DNA

<400>  757
agtaataatc agcggccctc a                                                 21



<210>  758
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 LCDR2 PRT

<400>  758
Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  759
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 LCDR3 DNA

<400>  759
gcagcatggg atgacagcct gaatggtaat gtgtta                                 36



<210>  760
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 LCDR3 PRT

<400>  760
Ala Ala Trp Asp Asp Ser Leu Asn Gly Asn Val Leu 
1               5                   10          


<210>  761
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VL DNA

<400>  761
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tggactccag      240

tctgaggatg aggctgacta ttactgtgca gcatgggatg acagcctgaa tggtaatgtg      300

ttatttggcg gagggaccaa gctgaccgtc cta                                   333



<210>  762
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VL PRT

<400>  762
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Asn Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  763
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VH DNA

<400>  763
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc taggtataac      300

agtggctggc ttgactactg gggccaggga accacggtca ccgtgtcctc a               351



<210>  764
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VH PRT

<400>  764
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asn Ser Gly Trp Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  765
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VH complete DNA

<400>  765
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc taggtataac      300

agtggctggc ttgactactg gggccaggga accacggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  766
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VH complete PRT

<400>  766
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asn Ser Gly Trp Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  767
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VL complete DNA

<400>  767
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatcctg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tggactccag      240

tctgaggatg aggctgacta ttactgtgca gcatgggatg acagcctgaa tggtaatgtg      300

ttatttggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  768
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-D07 VL complete PRT

<400>  768
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Asn Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  769
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 HCDR1 DNA

<400>  769
agctactata tgcac                                                        15



<210>  770
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 HCDR1 PRT

<400>  770
Ser Tyr Tyr Met His 
1               5   


<210>  771
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 HCDR2 DNA

<400>  771
ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51



<210>  772
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 HCDR2 PRT

<400>  772
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  773
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 HCDR3 DNA

<400>  773
gcgagtcggg attactatga tagtagtggt tatttgcgtc gaatgggggg cgactac          57



<210>  774
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 HCDR3 PRT

<400>  774
Ala Ser Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Leu Arg Arg Met Gly 
1               5                   10                  15      


Gly Asp Tyr 
            


<210>  775
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 LCDR1 DNA

<400>  775
gggggaaaca acattggaag taaaagtgtg cac                                    33



<210>  776
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 LCDR1 PRT

<400>  776
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  777
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 LCDR2 DNA

<400>  777
gatgatagcg accggccctc a                                                 21



<210>  778
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 LCDR2 PRT

<400>  778
Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210>  779
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 LCDR3 DNA

<400>  779
caggtgtggg acagcagcac tgcggta                                           27



<210>  780
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 LCDR3 PRT

<400>  780
Gln Val Trp Asp Ser Ser Thr Ala Val 
1               5                   


<210>  781
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VL DNA

<400>  781
cagtctgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gacagcagca ctgcggtatt cggcggaggg      300

accaagctga ccgtccta                                                    318



<210>  782
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VL PRT

<400>  782
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  783
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VH DNA

<400>  783
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc tagagcgagt      300

cgggattact atgatagtag tggttatttg cgtcgaatgg ggggcgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  784
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VH PRT

<400>  784
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Leu Arg Arg 
            100                 105                 110         


Met Gly Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  785
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VH complete DNA

<400>  785
gaggtgcagc tggtggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc tagagcgagt      300

cgggattact atgatagtag tggttatttg cgtcgaatgg ggggcgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  786
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VH complete PRT

<400>  786
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Arg Asp Tyr Tyr Asp Ser Ser Gly Tyr Leu Arg Arg 
            100                 105                 110         


Met Gly Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  787
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VL complete DNA

<400>  787
cagtctgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gacagcagca ctgcggtatt cggcggaggg      300

accaagctga ccgtcctagg tcagcccaag gctgcaccaa gtgtcactct gttcccgccc      360

tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac      420

ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag      480

accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg      540

acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc      600

accgtggaga agacagtggc ccctacagaa tgttca                                636



<210>  788
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU537-H08 VL complete PRT

<400>  788
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  789
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 HCDR1 DNA

<400>  789
acctatgcca tgggc                                                        15



<210>  790
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 HCDR1 PRT

<400>  790
Thr Tyr Ala Met Gly 
1               5   


<210>  791
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 HCDR2 DNA

<400>  791
actattagtg gtactggtgg tatcacatac tacgcagact ccgtgaaggg c                51



<210>  792
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 HCDR2 PRT

<400>  792
Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  793
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 HCDR3 DNA

<400>  793
gtcggagata attactatga taggagtggt aattatcaca tggactactt tgactac          57



<210>  794
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 HCDR3 PRT

<400>  794
Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  795
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 LCDR1 DNA

<400>  795
tctggaagca gctccaacat tgggaataat tatgtatcc                              39



<210>  796
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 LCDR1 PRT

<400>  796
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  797
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 LCDR2 DNA

<400>  797
gaagataatg agcgaccctc a                                                 21



<210>  798
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 LCDR2 PRT

<400>  798
Glu Asp Asn Glu Arg Pro Ser 
1               5           


<210>  799
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 LCDR3 DNA

<400>  799
ggaacatggg atagcagcct gagtgttatg tta                                    33



<210>  800
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 LCDR3 PRT

<400>  800
Gly Thr Trp Asp Ser Ser Leu Ser Val Met Leu 
1               5                   10      


<210>  801
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VL DNA

<400>  801
cagtctgtgt tgacgccgcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccaacacctc      120

ccaggaacag cccccaaact cctcatctat gaagataatg agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tccgccaccc tgggcatcac cggactccag      240

actggggacg agggcgattt ttactgcgga acatgggata gcagcctgag tgttatgtta      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  802
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VL PRT

<400>  802
Gln Ser Val Leu Thr Pro Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asp Asn Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Gly Asp Phe Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Met Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  803
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VH DNA

<400>  803
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgggctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  804
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VH PRT

<400>  804
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  805
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VH complete DNA

<400>  805
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgggctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  806
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VH complete PRT

<400>  806
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  807
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VL complete DNA

<400>  807
cagtctgtgt tgacgccgcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccaacacctc      120

ccaggaacag cccccaaact cctcatctat gaagataatg agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tccgccaccc tgggcatcac cggactccag      240

actggggacg agggcgattt ttactgcgga acatgggata gcagcctgag tgttatgtta      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  808
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-E01 VL complete PRT

<400>  808
Gln Ser Val Leu Thr Pro Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asp Asn Glu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Gly Asp Phe Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Met Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  809
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 HCDR1 DNA

<400>  809
acctatgcca tgagc                                                        15



<210>  810
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 HCDR1 PRT

<400>  810
Thr Tyr Ala Met Ser 
1               5   


<210>  811
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 HCDR2 DNA

<400>  811
actattagtg gtactggtgg tatcacatac tacgcagact ccgtgaaggg c                51



<210>  812
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 HCDR2 PRT

<400>  812
Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  813
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 HCDR3 DNA

<400>  813
gtcggagata attactatga taggagtggt aattatcaca tggactactt tgactac          57



<210>  814
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 HCDR3 PRT

<400>  814
Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  815
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 LCDR1 DNA

<400>  815
actgggagca gctccaacat cggggcagct tatgatgtac ac                          42



<210>  816
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 LCDR1 PRT

<400>  816
Thr Gly Ser Ser Ser Asn Ile Gly Ala Ala Tyr Asp Val His 
1               5                   10                  


<210>  817
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 LCDR2 DNA

<400>  817
gaaaacaaca agcggccctc a                                                 21



<210>  818
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 LCDR2 PRT

<400>  818
Glu Asn Asn Lys Arg Pro Ser 
1               5           


<210>  819
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 LCDR3 DNA

<400>  819
ggaacgtggg atggcagcct gagtgtt                                           27



<210>  820
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 LCDR3 PRT

<400>  820
Gly Thr Trp Asp Gly Ser Leu Ser Val 
1               5                   


<210>  821
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VL DNA

<400>  821
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcagcttatg atgtacactg gtaccagcag      120

cttccaggaa cggcccccaa actcctcatc tatgaaaaca acaagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acgtcagcca ccctgggcat caccggactc      240

cagactgggg acgaggccga ttatttctgc ggaacgtggg atggcagcct gagtgttttc      300

ggcggaggga ccaagctgac cgtccta                                          327



<210>  822
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VL PRT

<400>  822
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Ala 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Gly Ser 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  823
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VH DNA

<400>  823
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  824
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VH PRT

<400>  824
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  825
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VH complete DNA

<400>  825
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  826
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VH complete PRT

<400>  826
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  827
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VL complete DNA

<400>  827
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcagcttatg atgtacactg gtaccagcag      120

cttccaggaa cggcccccaa actcctcatc tatgaaaaca acaagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acgtcagcca ccctgggcat caccggactc      240

cagactgggg acgaggccga ttatttctgc ggaacgtggg atggcagcct gagtgttttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgcaccaag tgtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645



<210>  828
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C02 VL complete PRT

<400>  828
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Ala 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Phe Cys Gly Thr Trp Asp Gly Ser 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  829
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 HCDR1 DNA

<400>  829
acctatgcca tgagc                                                        15



<210>  830
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 HCDR1 PRT

<400>  830
Thr Tyr Ala Met Ser 
1               5   


<210>  831
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 HCDR2 DNA

<400>  831
actattagtg gtactggtgg tatcacatac tacgcagact ccgtgaaggg c                51



<210>  832
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 HCDR2 PRT

<400>  832
Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  833
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 HCDR3 DNA

<400>  833
gtcggagata attactatga taggagtggt aattatcaca tggactactt tgactac          57



<210>  834
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 HCDR3 PRT

<400>  834
Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  835
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 LCDR1 DNA

<400>  835
actgggagca cctccaacat cggggcaggt tatgatgttc ag                          42



<210>  836
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 LCDR1 PRT

<400>  836
Thr Gly Ser Thr Ser Asn Ile Gly Ala Gly Tyr Asp Val Gln 
1               5                   10                  


<210>  837
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 LCDR2 DNA

<400>  837
gaggacaaca atcggccctc a                                                 21



<210>  838
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 LCDR2 PRT

<400>  838
Glu Asp Asn Asn Arg Pro Ser 
1               5           


<210>  839
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 LCDR3 DNA

<400>  839
cagtcctctg tcagcagcct gagtgctgtg gta                                    33



<210>  840
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 LCDR3 PRT

<400>  840
Gln Ser Ser Val Ser Ser Leu Ser Ala Val Val 
1               5                   10      


<210>  841
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VL DNA

<400>  841
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcacctc caacatcggg gcaggttatg atgttcagtg gtaccagcag      120

cttccaggaa aagcccccaa actcctcgtc tatgaggaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggccgagg atgaggctga ttattactgc cagtcctctg tcagcagcct gagtgctgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  842
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VL PRT

<400>  842
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Thr Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Val Tyr Glu Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Val Ser Ser 
                85                  90                  95      


Leu Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  843
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VH DNA

<400>  843
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  844
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VH PRT

<400>  844
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  845
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VH complete DNA

<400>  845
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  846
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VH complete PRT

<400>  846
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  847
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VL complete DNA

<400>  847
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcacctc caacatcggg gcaggttatg atgttcagtg gtaccagcag      120

cttccaggaa aagcccccaa actcctcgtc tatgaggaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggccgagg atgaggctga ttattactgc cagtcctctg tcagcagcct gagtgctgtg      300

gtattcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  848
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-C06 VL complete PRT

<400>  848
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Thr Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Val Tyr Glu Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Val Ser Ser 
                85                  90                  95      


Leu Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  849
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 HCDR1 DNA

<400>  849
acctatgcca tgagc                                                        15



<210>  850
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 HCDR1 PRT

<400>  850
Thr Tyr Ala Met Ser 
1               5   


<210>  851
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 HCDR2 DNA

<400>  851
actattagtg gtactggtgg tatcacatac tacgcagact ccgtgaaggg c                51



<210>  852
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 HCDR2 PRT

<400>  852
Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  853
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 HCDR3 DNA

<400>  853
gtcggagata attactatga taggagtggt aattatcaca tggactactt tgactac          57



<210>  854
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 HCDR3 PRT

<400>  854
Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  855
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 LCDR1 DNA

<400>  855
actggaacca gcagtgacct tggtgcttat gactatgtct cc                          42



<210>  856
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 LCDR1 PRT

<400>  856
Thr Gly Thr Ser Ser Asp Leu Gly Ala Tyr Asp Tyr Val Ser 
1               5                   10                  


<210>  857
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 LCDR2 DNA

<400>  857
gatgtcaata atcggccctc a                                                 21



<210>  858
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 LCDR2 PRT

<400>  858
Asp Val Asn Asn Arg Pro Ser 
1               5           


<210>  859
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 LCDR3 DNA

<400>  859
aactcatata caagcagcag cacttgggtg                                        30



<210>  860
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 LCDR3 PRT

<400>  860
Asn Ser Tyr Thr Ser Ser Ser Thr Trp Val 
1               5                   10  


<210>  861
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VL DNA

<400>  861
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc ggtcaccatc       60

tcctgcactg gaaccagcag tgaccttggt gcttatgact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ataatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc aactcatata caagcagcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  862
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VL PRT

<400>  862
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  863
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VH DNA

<400>  863
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  864
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VH PRT

<400>  864
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  865
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VH complete DNA

<400>  865
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  866
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VH complete PRT

<400>  866
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  867
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VL complete DNA

<400>  867
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc ggtcaccatc       60

tcctgcactg gaaccagcag tgaccttggt gcttatgact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ataatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc aactcatata caagcagcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  868
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU536-C12 VL complete PRT

<400>  868
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  869
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 HCDR1 DNA

<400>  869
acctatgcca tgagc                                                        15



<210>  870
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 HCDR1 PRT

<400>  870
Thr Tyr Ala Met Ser 
1               5   


<210>  871
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 HCDR2 DNA

<400>  871
actattagtg gtactggtgg tatcacatac tacgcagact ccgtgaaggg c                51



<210>  872
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 HCDR2 PRT

<400>  872
Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  873
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 HCDR3 DNA

<400>  873
gtcggagata attactatga taggagtggt aattatcaca tggactactt tgactac          57



<210>  874
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 HCDR3 PRT

<400>  874
Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met Asp Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  875
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 LCDR1 DNA

<400>  875
actggaacca gcagtgatgt tgggagttat aaccttgtct cc                          42



<210>  876
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 LCDR1 PRT

<400>  876
Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 
1               5                   10                  


<210>  877
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 LCDR2 DNA

<400>  877
gagggcagtc agcggccctc a                                                 21



<210>  878
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 LCDR2 PRT

<400>  878
Glu Gly Ser Gln Arg Pro Ser 
1               5           


<210>  879
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 LCDR3 DNA

<400>  879
agctcatata caagcagcag caccgtggta                                        30



<210>  880
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 LCDR3 PRT

<400>  880
Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 
1               5                   10  


<210>  881
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VL DNA

<400>  881
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacaggc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actgatgatt tatgagggca gtcagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag caccgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  882
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VL PRT

<400>  882
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ala Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  883
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VH DNA

<400>  883
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  884
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VH PRT

<400>  884
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  885
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VH complete DNA

<400>  885
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta ctggtggtat cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagtcgga      300

gataattact atgataggag tggtaattat cacatggact actttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  886
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VH complete PRT

<400>  886
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Thr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Asp Asn Tyr Tyr Asp Arg Ser Gly Asn Tyr His Met 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  887
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VL complete DNA

<400>  887
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacaggc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actgatgatt tatgagggca gtcagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag caccgtggta      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  888
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU534-G10 VL complete PRT

<400>  888
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ala Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  889
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 HCDR1 DNA

<400>  889
agctactata tgcac                                                        15



<210>  890
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 HCDR1 PRT

<400>  890
Ser Tyr Tyr Met His 
1               5   


<210>  891
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 HCDR2 DNA

<400>  891
ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51



<210>  892
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 HCDR2 PRT

<400>  892
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  893
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 HCDR3 DNA

<400>  893
gaccgccatt actatgatag tagtggttct tcccaggcca cctttctctt tgactac          57



<210>  894
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 HCDR3 PRT

<400>  894
Asp Arg His Tyr Tyr Asp Ser Ser Gly Ser Ser Gln Ala Thr Phe Leu 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  895
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 LCDR1 DNA

<400>  895
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  896
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 LCDR1 PRT

<400>  896
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  897
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 LCDR2 DNA

<400>  897
ggtaacagca atcggccctc a                                                 21



<210>  898
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 LCDR2 PRT

<400>  898
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  899
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 LCDR3 DNA

<400>  899
cagtcctatg acagcagcct gaatgtc                                           27



<210>  900
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 LCDR3 PRT

<400>  900
Gln Ser Tyr Asp Ser Ser Leu Asn Val 
1               5                   


<210>  901
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VL DNA

<400>  901
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gaatgtcttc      300

ggaactggga ccaagctgac cgtccta                                          327



<210>  902
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VL PRT

<400>  902
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Asn Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  903
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VH DNA

<400>  903
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc tagagaccgc      300

cattactatg atagtagtgg ttcttcccag gccacctttc tctttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  904
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VH PRT

<400>  904
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg His Tyr Tyr Asp Ser Ser Gly Ser Ser Gln Ala Thr 
            100                 105                 110         


Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  905
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VH complete DNA

<400>  905
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc tagagaccgc      300

cattactatg atagtagtgg ttcttcccag gccacctttc tctttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  906
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VH complete PRT

<400>  906
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg His Tyr Tyr Asp Ser Ser Gly Ser Ser Gln Ala Thr 
            100                 105                 110         


Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  907
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VL complete DNA

<400>  907
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gaatgtcttc      300

ggaactggga ccaagctgac cgtcctaggt cagcccaagg ctgcaccaag tgtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggcc tggaaggcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttca                      645



<210>  908
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A01 VL complete PRT

<400>  908
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Asn Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  909
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 HCDR1 DNA

<400>  909
agctatgcta tcagc                                                        15



<210>  910
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 HCDR1 PRT

<400>  910
Ser Tyr Ala Ile Ser 
1               5   


<210>  911
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 HCDR2 DNA

<400>  911
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  912
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 HCDR2 PRT

<400>  912
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  913
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 HCDR3 DNA

<400>  913
caaatctggg cttatgatag tagtggttac cccgtcccgg ccgaatactt ccagcac          57



<210>  914
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 HCDR3 PRT

<400>  914
Gln Ile Trp Ala Tyr Asp Ser Ser Gly Tyr Pro Val Pro Ala Glu Tyr 
1               5                   10                  15      


Phe Gln His 
            


<210>  915
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 LCDR1 DNA

<400>  915
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  916
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 LCDR1 PRT

<400>  916
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  917
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 LCDR2 DNA

<400>  917
ggtaacagca atcggccctc a                                                 21



<210>  918
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 LCDR2 PRT

<400>  918
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  919
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 LCDR3 DNA

<400>  919
cagtcctatg acagcagcct gagtggtgtg gta                                    33



<210>  920
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 LCDR3 PRT

<400>  920
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  921
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VL DNA

<400>  921
cagtctgtgt tgacgcagcc gccctcggtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggtgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  922
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VL PRT

<400>  922
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  923
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VH DNA

<400>  923
caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc acgtcaaatc      300

tgggcttatg atagtagtgg ttaccccgtc ccggccgaat acttccagca ctggggccag      360

ggcaccctgg tcaccgtgtc ctca                                             384



<210>  924
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VH PRT

<400>  924
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ile Trp Ala Tyr Asp Ser Ser Gly Tyr Pro Val Pro Ala 
            100                 105                 110         


Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  925
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VH complete DNA

<400>  925
caggtgcagc tggtggagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc acgtcaaatc      300

tgggcttatg atagtagtgg ttaccccgtc ccggccgaat acttccagca ctggggccag      360

ggcaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  926
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VH complete PRT

<400>  926
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ile Trp Ala Tyr Asp Ser Ser Gly Tyr Pro Val Pro Ala 
            100                 105                 110         


Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  927
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VL complete DNA

<400>  927
cagtctgtgt tgacgcagcc gccctcggtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggtgtg      300

gtattcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  928
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A02 VL complete PRT

<400>  928
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  929
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 HCDR1 DNA

<400>  929
agctatgcta tcagc                                                        15



<210>  930
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 HCDR1 PRT

<400>  930
Ser Tyr Ala Ile Ser 
1               5   


<210>  931
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 HCDR2 DNA

<400>  931
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  932
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 HCDR2 PRT

<400>  932
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  933
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 HCDR3 DNA

<400>  933
agtgactccg gatatagtgg ctacgggtac tttgactac                              39



<210>  934
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 HCDR3 PRT

<400>  934
Ser Asp Ser Gly Tyr Ser Gly Tyr Gly Tyr Phe Asp Tyr 
1               5                   10              


<210>  935
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 LCDR1 DNA

<400>  935
actggaacca gcagcgacgt tggtcgttat aactatgtct cc                          42



<210>  936
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 LCDR1 PRT

<400>  936
Thr Gly Thr Ser Ser Asp Val Gly Arg Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  937
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 LCDR2 DNA

<400>  937
gatgtcacta atcggccctc a                                                 21



<210>  938
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 LCDR2 PRT

<400>  938
Asp Val Thr Asn Arg Pro Ser 
1               5           


<210>  939
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 LCDR3 DNA

<400>  939
acctcatata caagcagtaa cactcttgtg ata                                    33



<210>  940
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 LCDR3 PRT

<400>  940
Thr Ser Tyr Thr Ser Ser Asn Thr Leu Val Ile 
1               5                   10      


<210>  941
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VL DNA

<400>  941
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ccggacagtc gatctccatc       60

tcctgcactg gaaccagcag cgacgttggt cgttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ctaatcggcc ctcaggggtt      180

tctagtcgct tctctggctc caagtctggc aacgcggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga gtattattgc acctcatata caagcagtaa cactcttgtg      300

atattcggcg gagggaccaa ggtcaccgtc cta                                   333



<210>  942
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VL PRT

<400>  942
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Ser Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Arg Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Ala Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Leu Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  943
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VH DNA

<400>  943
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaagtgac      300

tccggatata gtggctacgg gtactttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctca                                                                 366



<210>  944
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VH PRT

<400>  944
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Ser Gly Tyr Ser Gly Tyr Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  945
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VH complete DNA

<400>  945
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaagtgac      300

tccggatata gtggctacgg gtactttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tccagtggcc      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtgggcgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa cagctcccat cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaaa gcctctccct gtccccgggt                                      1350



<210>  946
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VH complete PRT

<400>  946
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Ser Gly Tyr Ser Gly Tyr Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  947
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VL complete DNA

<400>  947
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ccggacagtc gatctccatc       60

tcctgcactg gaaccagcag cgacgttggt cgttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca ctaatcggcc ctcaggggtt      180

tctagtcgct tctctggctc caagtctggc aacgcggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga gtattattgc acctcatata caagcagtaa cactcttgtg      300

atattcggcg gagggaccaa ggtcaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  948
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-A05 VL complete PRT

<400>  948
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Ser Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Arg Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Ala Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Thr Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Thr Leu Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  949
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 HCDR1 DNA

<400>  949
agtagtaact ggtggagt                                                     18



<210>  950
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 HCDR1 PRT

<400>  950
Ser Ser Asn Trp Trp Ser 
1               5       


<210>  951
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 HCDR2 DNA

<400>  951
agtatctatc atagtgggag cacctactac aacccgtccc tcaagagt                    48



<210>  952
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 HCDR2 PRT

<400>  952
Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  953
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 HCDR3 DNA

<400>  953
gttcgccccg agaggaggtt tccttactac tactacatgg acgtc                       45



<210>  954
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 HCDR3 PRT

<400>  954
Val Arg Pro Glu Arg Arg Phe Pro Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  955
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 LCDR1 DNA

<400>  955
tctggaagca actccaacat cggaactaat actgtaaac                              39



<210>  956
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 LCDR1 PRT

<400>  956
Ser Gly Ser Asn Ser Asn Ile Gly Thr Asn Thr Val Asn 
1               5                   10              


<210>  957
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 LCDR2 DNA

<400>  957
actaatgatc agcggccctc a                                                 21



<210>  958
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 LCDR2 PRT

<400>  958
Thr Asn Asp Gln Arg Pro Ser 
1               5           


<210>  959
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 LCDR3 DNA

<400>  959
gcagcatggg atgacagcct gagtcgttgg gtg                                    33



<210>  960
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 LCDR3 PRT

<400>  960
Ala Ala Trp Asp Asp Ser Leu Ser Arg Trp Val 
1               5                   10      


<210>  961
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VL DNA

<400>  961
cagtctgtgc tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcaactc caacatcgga actaatactg taaactggta ccagcaactc      120

ccaggaacgg cccccaaact cctcatctat actaatgatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tccgacgatg aggctgatta ttactgtgca gcatgggatg acagcctgag tcgttgggtg      300

ttcggcggag ggaccaaggt caccgtccta                                       330



<210>  962
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VL PRT

<400>  962
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Arg Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  963
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VH DNA

<400>  963
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtagtaact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg agtatctatc atagtgggag cacctactac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc cagagttcgc      300

cccgagagga ggtttcctta ctactactac atggacgtct ggggcaaagg gaccacggtc      360

accgtgtcct ca                                                          372



<210>  964
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VH PRT

<400>  964
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Pro Glu Arg Arg Phe Pro Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  965
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VH complete DNA

<400>  965
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtagtaact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg agtatctatc atagtgggag cacctactac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc cagagttcgc      300

cccgagagga ggtttcctta ctactactac atggacgtct ggggcaaagg gaccacggtc      360

accgtgtcct cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctcca      720

gtggccggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg ggcgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaacagc tcccatcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaaaagcct ctccctgtcc ccgggt                               1356



<210>  966
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VH complete PRT

<400>  966
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Pro Glu Arg Arg Phe Pro Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
225                 230                 235                 240 


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  967
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VL complete DNA

<400>  967
cagtctgtgc tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcaactc caacatcgga actaatactg taaactggta ccagcaactc      120

ccaggaacgg cccccaaact cctcatctat actaatgatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tccgacgatg aggctgatta ttactgtgca gcatgggatg acagcctgag tcgttgggtg      300

ttcggcggag ggaccaaggt caccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  968
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B03 VL complete PRT

<400>  968
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Thr Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Arg Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  969
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 HCDR1 DNA

<400>  969
agctactata tgcac                                                        15



<210>  970
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 HCDR1 PRT

<400>  970
Ser Tyr Tyr Met His 
1               5   


<210>  971
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 HCDR2 DNA

<400>  971
ataatcaacc ctagtggtgg tagcacaagc tacgcacaga agttccaggg c                51



<210>  972
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 HCDR2 PRT

<400>  972
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  973
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 HCDR3 DNA

<400>  973
gaccgccatt actatgatag tagtggttct tcccaggcca cctttctctt tgactac          57



<210>  974
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 HCDR3 PRT

<400>  974
Asp Arg His Tyr Tyr Asp Ser Ser Gly Ser Ser Gln Ala Thr Phe Leu 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  975
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 LCDR1 DNA

<400>  975
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  976
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 LCDR1 PRT

<400>  976
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  977
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 LCDR2 DNA

<400>  977
ggtaacagca atcggccctc a                                                 21



<210>  978
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 LCDR2 PRT

<400>  978
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  979
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 LCDR3 DNA

<400>  979
cagtcctatg acagcagcct gagtggttcg ttg                                    33



<210>  980
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 LCDR3 PRT

<400>  980
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Leu 
1               5                   10      


<210>  981
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VL DNA

<400>  981
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

ttgttcggcg gaggcaccca ggtgaccgtc ctc                                   333



<210>  982
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VL PRT

<400>  982
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Leu Phe Gly Gly Gly Thr Gln Val Thr Val Leu 
            100                 105                 110     


<210>  983
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VH DNA

<400>  983
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc tagagaccgc      300

cattactatg atagtagtgg ttcttcccag gccacctttc tctttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctca                                             384



<210>  984
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VH PRT

<400>  984
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg His Tyr Tyr Asp Ser Ser Gly Ser Ser Gln Ala Thr 
            100                 105                 110         


Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  985
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VH complete DNA

<400>  985
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc tagagaccgc      300

cattactatg atagtagtgg ttcttcccag gccacctttc tctttgacta ctggggccag      360

ggaaccctgg tcaccgtgtc ctcagctagc accaagggcc catcggtctt ccccctggca      420

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      480

ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      540

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      600

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      660

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      720

ccagcacctc cagtggccgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tgggcgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgggtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaaca gctcccatcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaaaagc ctctccctgt ccccgggt                  1368



<210>  986
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VH complete PRT

<400>  986
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg His Tyr Tyr Asp Ser Ser Gly Ser Ser Gln Ala Thr 
            100                 105                 110         


Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  987
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VL complete DNA

<400>  987
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

ttgttcggcg gaggcaccca ggtgaccgtc ctcggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  988
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B04 VL complete PRT

<400>  988
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Leu Phe Gly Gly Gly Thr Gln Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  989
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 HCDR1 DNA

<400>  989
agctatgcca tgagc                                                        15



<210>  990
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 HCDR1 PRT

<400>  990
Ser Tyr Ala Met Ser 
1               5   


<210>  991
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 HCDR2 DNA

<400>  991
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  992
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 HCDR2 PRT

<400>  992
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  993
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 HCDR3 DNA

<400>  993
cctattgacc acgggatttt tgactac                                           27



<210>  994
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 HCDR3 PRT

<400>  994
Pro Ile Asp His Gly Ile Phe Asp Tyr 
1               5                   


<210>  995
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 LCDR1 DNA

<400>  995
gggggaaaca acattggaag taaaagtgtg cac                                    33



<210>  996
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 LCDR1 PRT

<400>  996
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  997
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 LCDR2 DNA

<400>  997
tatgatagcg accggccctc a                                                 21



<210>  998
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 LCDR2 PRT

<400>  998
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210>  999
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 LCDR3 DNA

<400>  999
caggtgtggg atagtagtag tgatcatgtg gta                                    33



<210>  1000
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 LCDR3 PRT

<400>  1000
Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  1001
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VL DNA

<400>  1001
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca agctgaccgt ccta                                             324



<210>  1002
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VL PRT

<400>  1002
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  1003
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VH DNA

<400>  1003
caggttcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacctatt      300

gaccacggga tttttgacta ctggggccag ggaaccctgg tcaccgtgtc ctca            354



<210>  1004
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VH PRT

<400>  1004
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ile Asp His Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  1005
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VH complete DNA

<400>  1005
caggttcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacctatt      300

gaccacggga tttttgacta ctggggccag ggaaccctgg tcaccgtgtc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctc cagtggccgg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tgggcgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaaca gctcccatcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaaaagc     1320

ctctccctgt ccccgggt                                                   1338



<210>  1006
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VH complete PRT

<400>  1006
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Ile Asp His Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  1007
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VL complete DNA

<400>  1007
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg caccaagtgt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642



<210>  1008
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-B06 VL complete PRT

<400>  1008
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  1009
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 HCDR1 DNA

<400>  1009
agttatgata tcaac                                                        15



<210>  1010
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 HCDR1 PRT

<400>  1010
Ser Tyr Asp Ile Asn 
1               5   


<210>  1011
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 HCDR2 DNA

<400>  1011
tggatgaacc ctaacagtgg taacacaggc tatgcacaga agttccaggg c                51



<210>  1012
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 HCDR2 PRT

<400>  1012
Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1013
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 HCDR3 DNA

<400>  1013
aactcgttag gagctgctac tggctggttc gacccc                                 36



<210>  1014
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 HCDR3 PRT

<400>  1014
Asn Ser Leu Gly Ala Ala Thr Gly Trp Phe Asp Pro 
1               5                   10          


<210>  1015
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 LCDR1 DNA

<400>  1015
tctggaagca gctccaacat cggaagtaat tatgtatac                              39



<210>  1016
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 LCDR1 PRT

<400>  1016
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  1017
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 LCDR2 DNA

<400>  1017
aggaataatc agcggccctc a                                                 21



<210>  1018
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 LCDR2 PRT

<400>  1018
Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  1019
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 LCDR3 DNA

<400>  1019
gcagcatggg atgacagcct ggta                                              24



<210>  1020
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 LCDR3 PRT

<400>  1020
Ala Ala Trp Asp Asp Ser Leu Val 
1               5               


<210>  1021
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VL DNA

<400>  1021
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctggt attcggcgga      300

gggaccaagg tcaccgtcct a                                                321



<210>  1022
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VL PRT

<400>  1022
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  1023
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VH DNA

<400>  1023
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggaactcg      300

ttaggagctg ctactggctg gttcgacccc tggggccagg gaaccctggt caccgtgtcc      360

tca                                                                    363



<210>  1024
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VH PRT

<400>  1024
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ser Leu Gly Ala Ala Thr Gly Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1025
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VH complete DNA

<400>  1025
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccagggcag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggaactcg      300

ttaggagctg ctactggctg gttcgacccc tggggccagg gaaccctggt caccgtgtcc      360

tcagctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctcc agtggccgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt gggcgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaacag ctcccatccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaaaagcc tctccctgtc cccgggt                                         1347



<210>  1026
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VH complete PRT

<400>  1026
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ser Leu Gly Ala Ala Thr Gly Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
    


<210>  1027
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VL complete DNA

<400>  1027
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctggt attcggcgga      300

gggaccaagg tcaccgtcct aggtcagccc aaggctgcac caagtgtcac tctgttcccg      360

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             639



<210>  1028
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D01 VL complete PRT

<400>  1028
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  1029
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 HCDR1 DNA

<400>  1029
agctatgcta tcagc                                                        15



<210>  1030
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 HCDR1 PRT

<400>  1030
Ser Tyr Ala Ile Ser 
1               5   


<210>  1031
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 HCDR2 DNA

<400>  1031
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  1032
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 HCDR2 PRT

<400>  1032
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1033
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 HCDR3 DNA

<400>  1033
gaaacctcca gtggctggag tttccttgac tac                                    33



<210>  1034
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 HCDR3 PRT

<400>  1034
Glu Thr Ser Ser Gly Trp Ser Phe Leu Asp Tyr 
1               5                   10      


<210>  1035
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 LCDR1 DNA

<400>  1035
gggggaaaca acattggaag taaaagtgtg cac                                    33



<210>  1036
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 LCDR1 PRT

<400>  1036
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  1037
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 LCDR2 DNA

<400>  1037
tatgatagcg accggccctc a                                                 21



<210>  1038
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 LCDR2 PRT

<400>  1038
Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210>  1039
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 LCDR3 DNA

<400>  1039
caggtgtggg atagtagtag tgatcatgtg gta                                    33



<210>  1040
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 LCDR3 PRT

<400>  1040
Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  1041
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VL DNA

<400>  1041
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca aggtcaccgt ccta                                             324



<210>  1042
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VL PRT

<400>  1042
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  1043
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VH DNA

<400>  1043
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaaacc      300

tccagtggct ggagtttcct tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  1044
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VH PRT

<400>  1044
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ser Ser Gly Trp Ser Phe Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1045
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VH complete DNA

<400>  1045
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagaaacc      300

tccagtggct ggagtttcct tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  1046
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VH complete PRT

<400>  1046
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ser Ser Gly Trp Ser Phe Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  1047
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VL complete DNA

<400>  1047
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca aggtcaccgt cctaggtcag cccaaggctg caccaagtgt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642



<210>  1048
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-D02 VL complete PRT

<400>  1048
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  1049
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 HCDR1 DNA

<400>  1049
agttatagta ttgtc                                                        15



<210>  1050
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 HCDR1 PRT

<400>  1050
Ser Tyr Ser Ile Val 
1               5   


<210>  1051
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 HCDR2 DNA

<400>  1051
gggatcatcc ctatttttgg tactacaaac tatgcacaga agttccaggg c                51



<210>  1052
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 HCDR2 PRT

<400>  1052
Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1053
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 HCDR3 DNA

<400>  1053
tctctgggag ccactcgtga ctac                                              24



<210>  1054
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 HCDR3 PRT

<400>  1054
Ser Leu Gly Ala Thr Arg Asp Tyr 
1               5               


<210>  1055
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 LCDR1 DNA

<400>  1055
tctggaagca gctccaacat cggaaataat gctgtaaac                              39



<210>  1056
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 LCDR1 PRT

<400>  1056
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  1057
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 LCDR2 DNA

<400>  1057
tatgatgatc tgctgccctc a                                                 21



<210>  1058
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 LCDR2 PRT

<400>  1058
Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  1059
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 LCDR3 DNA

<400>  1059
gcagcatggg atgacagcct gaatggtccg gtg                                    33



<210>  1060
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 LCDR3 PRT

<400>  1060
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  1061
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VL DNA

<400>  1061
tcctatgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccggtg      300

ttcggcggag ggaccaaggt caccgtccta                                       330



<210>  1062
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VL PRT

<400>  1062
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  1063
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VH DNA

<400>  1063
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatagta ttgtctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atcatcccta tttttggtac tacaaactat      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacaag cacagccttc      240

atggagctga gcaacctaaa atctgaggac acggccgtct atttctgtgc gagatctctg      300

ggagccactc gtgactactg gggccaggga accctggtca ccgtgtcctc a               351



<210>  1064
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VH PRT

<400>  1064
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Ala Thr Arg Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  1065
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VH complete DNA

<400>  1065
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agttatagta ttgtctgggt gcgacaggcc      120

cctggacaag gacttgagtg gatgggaggg atcatcccta tttttggtac tacaaactat      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacaag cacagccttc      240

atggagctga gcaacctaaa atctgaggac acggccgtct atttctgtgc gagatctctg      300

ggagccactc gtgactactg gggccaggga accctggtca ccgtgtcctc agctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctccag tggccggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg gcgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaacagct cccatccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaaaagcctc     1320

tccctgtccc cgggt                                                      1335



<210>  1066
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VH complete PRT

<400>  1066
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Ile Val Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Ser Asn Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Gly Ala Thr Arg Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  1067
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VL complete DNA

<400>  1067
tcctatgtgc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagctc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccggtg      300

ttcggcggag ggaccaaggt caccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  1068
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E01 VL complete PRT

<400>  1068
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  1069
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 HCDR1 DNA

<400>  1069
agctatacta tcagc                                                        15



<210>  1070
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 HCDR1 PRT

<400>  1070
Ser Tyr Thr Ile Ser 
1               5   


<210>  1071
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 HCDR2 DNA

<400>  1071
aggatcatcc ctatccttgg tatagcaaac tacgcacaga agttccaggg c                51



<210>  1072
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 HCDR2 PRT

<400>  1072
Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1073
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 HCDR3 DNA

<400>  1073
gatatggtct ctgtaggggc agctggacct tactactttg actac                       45



<210>  1074
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 HCDR3 PRT

<400>  1074
Asp Met Val Ser Val Gly Ala Ala Gly Pro Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  1075
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 LCDR1 DNA

<400>  1075
actgggagca gctccaacat cggggcaggt tatgatgtac ac                          42



<210>  1076
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 LCDR1 PRT

<400>  1076
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  1077
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 LCDR2 DNA

<400>  1077
ggtaacagca atcggccctc a                                                 21



<210>  1078
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 LCDR2 PRT

<400>  1078
Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  1079
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 LCDR3 DNA

<400>  1079
cagtcctatg acagcagcct gagtggttcg gta                                    33



<210>  1080
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 LCDR3 PRT

<400>  1080
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 
1               5                   10      


<210>  1081
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VL DNA

<400>  1081
cagtctgtgt tgacgcagcc gccctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctgtc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333



<210>  1082
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VL PRT

<400>  1082
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Val Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1083
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VH DNA

<400>  1083
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatatg      300

gtctctgtag gggcagctgg accttactac tttgactact ggggccaggg aaccctggtc      360

accgtgtcct ca                                                          372



<210>  1084
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VH PRT

<400>  1084
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Val Ser Val Gly Ala Ala Gly Pro Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  1085
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VH complete DNA

<400>  1085
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatacta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatatg      300

gtctctgtag gggcagctgg accttactac tttgactact ggggccaggg aaccctggtc      360

accgtgtcct cagctagcac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctcca      720

gtggccggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg ggcgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaacagc tcccatcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaaaagcct ctccctgtcc ccgggt                               1356



<210>  1086
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VH complete PRT

<400>  1086
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Val Ser Val Gly Ala Ala Gly Pro Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
225                 230                 235                 240 


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  1087
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VL complete DNA

<400>  1087
cagtctgtgt tgacgcagcc gccctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctgtc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttcg      300

gtattcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  1088
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E02 VL complete PRT

<400>  1088
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Val Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  1089
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 HCDR1 DNA

<400>  1089
agctatgcta tcagc                                                        15



<210>  1090
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 HCDR1 PRT

<400>  1090
Ser Tyr Ala Ile Ser 
1               5   


<210>  1091
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 HCDR2 DNA

<400>  1091
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  1092
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 HCDR2 PRT

<400>  1092
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1093
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 HCDR3 DNA

<400>  1093
ggacgtggat acagctatgg tcacgactac                                        30



<210>  1094
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 HCDR3 PRT

<400>  1094
Gly Arg Gly Tyr Ser Tyr Gly His Asp Tyr 
1               5                   10  


<210>  1095
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 LCDR1 DNA

<400>  1095
tctggaagca gctccaacat cggaaataat gctgtaaac                              39



<210>  1096
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 LCDR1 PRT

<400>  1096
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  1097
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 LCDR2 DNA

<400>  1097
tatgatgatc tgctgccctc a                                                 21



<210>  1098
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 LCDR2 PRT

<400>  1098
Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  1099
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 LCDR3 DNA

<400>  1099
gcagcctggg atgacagcct gaatggttgg gtg                                    33



<210>  1100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 LCDR3 PRT

<400>  1100
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  1101
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VL DNA

<400>  1101
tcctatgagc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagttc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcctgggatg acagcctgaa tggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  1102
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VL PRT

<400>  1102
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Phe Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  1103
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VH DNA

<400>  1103
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggacgt      300

ggatacagct atggtcacga ctactggggc cagggaaccc tggtcaccgt gtcctca         357



<210>  1104
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VH PRT

<400>  1104
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Tyr Ser Tyr Gly His Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  1105
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VH complete DNA

<400>  1105
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggacgt      300

ggatacagct atggtcacga ctactggggc cagggaaccc tggtcaccgt gtcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctccagtggc cggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtgggcgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa acagctccca tcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaaa     1320

agcctctccc tgtccccggg t                                               1341



<210>  1106
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VH complete PRT

<400>  1106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Tyr Ser Tyr Gly His Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  1107
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VL complete DNA

<400>  1107
tcctatgagc tgactcagcc accctcggtg tctgaagccc ccaggcagag ggtcaccatc       60

tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta ccagcagttc      120

ccaggaaagg ctcccaaact cctcatctat tatgatgatc tgctgccctc aggggtctct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcctgggatg acagcctgaa tggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  1108
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-E04 VL complete PRT

<400>  1108
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Phe Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  1109
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 HCDR1 DNA

<400>  1109
ggctactata tgcac                                                        15



<210>  1110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 HCDR1 PRT

<400>  1110
Gly Tyr Tyr Met His 
1               5   


<210>  1111
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 HCDR2 DNA

<400>  1111
cagatcaacc ctaacagtgg tggcacaaac tatgcacaga agtttcaggg c                51



<210>  1112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 HCDR2 PRT

<400>  1112
Gln Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1113
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 HCDR3 DNA

<400>  1113
ggggaaggct ttgactac                                                     18



<210>  1114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 HCDR3 PRT

<400>  1114
Gly Glu Gly Phe Asp Tyr 
1               5       


<210>  1115
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 LCDR1 DNA

<400>  1115
tctggaagca gctccaacat cggaagtaat tatgtatac                              39



<210>  1116
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 LCDR1 PRT

<400>  1116
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  1117
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 LCDR2 DNA

<400>  1117
aggaataatc agcggccctc a                                                 21



<210>  1118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 LCDR2 PRT

<400>  1118
Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  1119
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 LCDR3 DNA

<400>  1119
gcagcatggg atgacagcct gagtggtgtg gta                                    33



<210>  1120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 LCDR3 PRT

<400>  1120
Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  1121
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VL DNA

<400>  1121
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgagggtg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtgtggta      300

ttcggcggag ggaccaaggt caccgtccta                                       330



<210>  1122
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VL PRT

<400>  1122
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Gly Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  1123
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VH DNA

<400>  1123
gaggtgcagc tgttggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacag atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gaggggggaa      300

ggctttgact actggggcca gggaaccctg gtcaccgtgt cctca                      345



<210>  1124
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VH PRT

<400>  1124
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  1125
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VH complete DNA

<400>  1125
gaggtgcagc tgttggagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggacag atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gaggggggaa      300

ggctttgact actggggcca gggaaccctg gtcaccgtgt cctcagctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct ccagtggccg gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      780

gtgggcgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc      900

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      960

tccaacaaac agctcccatc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaaaag cctctccctg     1320

tccccgggt                                                             1329



<210>  1126
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VH complete PRT

<400>  1126
Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  1127
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VL complete DNA

<400>  1127
tcctatgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgagggtg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtgtggta      300

ttcggcggag ggaccaaggt caccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  1128
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F03 VL complete PRT

<400>  1128
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Gly Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  1129
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 HCDR1 DNA

<400>  1129
agctatgcta tcagc                                                        15



<210>  1130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 HCDR1 PRT

<400>  1130
Ser Tyr Ala Ile Ser 
1               5   


<210>  1131
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 HCDR2 DNA

<400>  1131
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  1132
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 HCDR2 PRT

<400>  1132
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1133
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 HCDR3 DNA

<400>  1133
ggagctgggg aaattgacta c                                                 21



<210>  1134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 HCDR3 PRT

<400>  1134
Gly Ala Gly Glu Ile Asp Tyr 
1               5           


<210>  1135
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 LCDR1 DNA

<400>  1135
actgggagca gctccaacat cggggcaggt tatgatgtac ag                          42



<210>  1136
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 LCDR1 PRT

<400>  1136
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val Gln 
1               5                   10                  


<210>  1137
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 LCDR2 DNA

<400>  1137
gctaacacct atcggccctc a                                                 21



<210>  1138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 LCDR2 PRT

<400>  1138
Ala Asn Thr Tyr Arg Pro Ser 
1               5           


<210>  1139
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 LCDR3 DNA

<400>  1139
tcaacacgag atgacaacct ggatggtgtg ata                                    33



<210>  1140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 LCDR3 PRT

<400>  1140
Ser Thr Arg Asp Asp Asn Leu Asp Gly Val Ile 
1               5                   10      


<210>  1141
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VL DNA

<400>  1141
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacagtg gtaccaacaa      120

cttccaggaa cagcccccaa actcctcatc tatgctaaca cctatcggcc ctcaggggtc      180

cctgaccgat tctctgcctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cactctgagg atgaggctga ttattattgt tcaacacgag atgacaacct ggatggtgtg      300

atattcggcg gagggaccaa gttgaccgtc cta                                   333



<210>  1142
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VL PRT

<400>  1142
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Thr Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


His Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Asp Asp Asn 
                85                  90                  95      


Leu Asp Gly Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1143
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VH DNA

<400>  1143
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgcgc gagaggagct      300

ggggaaattg actactgggg ccagggaacc ctggtcaccg tgtcctca                   348



<210>  1144
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VH PRT

<400>  1144
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Glu Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1145
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VH complete DNA

<400>  1145
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgcgc gagaggagct      300

ggggaaattg actactgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctccagtgg ccggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtgggcg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgggtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aacagctccc atcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa aagcctctcc     1320

ctgtccccgg gt                                                         1332



<210>  1146
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VH complete PRT

<400>  1146
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Glu Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  1147
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VL complete DNA

<400>  1147
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacagtg gtaccaacaa      120

cttccaggaa cagcccccaa actcctcatc tatgctaaca cctatcggcc ctcaggggtc      180

cctgaccgat tctctgcctc caagtctggc acctcagcct ccctggccat cagtgggctc      240

cactctgagg atgaggctga ttattattgt tcaacacgag atgacaacct ggatggtgtg      300

atattcggcg gagggaccaa gttgaccgtc ctaggtcagc ccaaggctgc accaagtgtc      360

actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc      420

ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc      480

aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc      540

agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc      600

acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a               651



<210>  1148
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F04 VL complete PRT

<400>  1148
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Thr Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


His Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Arg Asp Asp Asn 
                85                  90                  95      


Leu Asp Gly Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  1149
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 HCDR1 DNA

<400>  1149
agctatggca tgcac                                                        15



<210>  1150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 HCDR1 PRT

<400>  1150
Ser Tyr Gly Met His 
1               5   


<210>  1151
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 HCDR2 DNA

<400>  1151
gttatgtcat atgatggaag taaaaaatac tatgcagact ccgtgaaggg c                51



<210>  1152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 HCDR2 PRT

<400>  1152
Val Met Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  1153
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 HCDR3 DNA

<400>  1153
cagggtatgg acgtc                                                        15



<210>  1154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 HCDR3 PRT

<400>  1154
Gln Gly Met Asp Val 
1               5   


<210>  1155
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 LCDR1 DNA

<400>  1155
gggggaaaca acattggaag taaaagtgtg cac                                    33



<210>  1156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 LCDR1 PRT

<400>  1156
Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  1157
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 LCDR2 DNA

<400>  1157
tatattagcg accggccctc a                                                 21



<210>  1158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 LCDR2 PRT

<400>  1158
Tyr Ile Ser Asp Arg Pro Ser 
1               5           


<210>  1159
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 LCDR3 DNA

<400>  1159
cacgtgtggg atagtagtag tgatcatgtg gta                                    33



<210>  1160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 LCDR3 PRT

<400>  1160
His Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  1161
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VL DNA

<400>  1161
cagtctgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgttggtcat ctattatatt agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg      240

gatgaggccg cctattactg tcacgtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca agctgaccgt ccta                                             324



<210>  1162
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VL PRT

<400>  1162
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Ile Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Ala Tyr Tyr Cys His Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  1163
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VH DNA

<400>  1163
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atgtcatatg atggaagtaa aaaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt cactcagggt      300

atggacgtct ggggccaagg gaccctggtc accgtgtcct ca                         342



<210>  1164
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VH PRT

<400>  1164
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Gln Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1165
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VH complete DNA

<400>  1165
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atgtcatatg atggaagtaa aaaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt cactcagggt      300

atggacgtct ggggccaagg gaccctggtc accgtgtcct cagctagcac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      660

cacacatgcc caccgtgccc agcacctcca gtggccggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

ggcgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg ggtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaacagc tcccatcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc     1320

ccgggt                                                                1326



<210>  1166
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VH complete PRT

<400>  1166
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Gln Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440         


<210>  1167
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VL complete DNA

<400>  1167
cagtctgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgttggtcat ctattatatt agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg      240

gatgaggccg cctattactg tcacgtgtgg gatagtagta gtgatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggtcag cccaaggctg caccaagtgt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642



<210>  1168
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU505-F05 VL complete PRT

<400>  1168
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Ile Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Ala Tyr Tyr Cys His Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  1169
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 HCDR1 DNA

<400>  1169
agctatgcca tgagc                                                        15



<210>  1170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 HCDR1 PRT

<400>  1170
Ser Tyr Ala Met Ser 
1               5   


<210>  1171
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 HCDR2 DNA

<400>  1171
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  1172
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 HCDR2 PRT

<400>  1172
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  1173
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 HCDR3 DNA

<400>  1173
gatcgatttt tggagtggtt attcacggga ccatttgact ac                          42



<210>  1174
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 HCDR3 PRT

<400>  1174
Asp Arg Phe Leu Glu Trp Leu Phe Thr Gly Pro Phe Asp Tyr 
1               5                   10                  


<210>  1175
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 LCDR1 DNA

<400>  1175
caggcgagtc aggacattag caactattta aat                                    33



<210>  1176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 LCDR1 PRT

<400>  1176
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  1177
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 LCDR2 DNA

<400>  1177
gatgcatcca atttggaaac a                                                 21



<210>  1178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 LCDR2 PRT

<400>  1178
Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  1179
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 LCDR3 DNA

<400>  1179
caccagtatg ataatttccc ctacact                                           27



<210>  1180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 LCDR3 PRT

<400>  1180
His Gln Tyr Asp Asn Phe Pro Tyr Thr 
1               5                   


<210>  1181
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VL DNA

<400>  1181
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggaaagat ttcactttta tcatcaacaa cctgcagcct      240

gatgacattg caacatatta ctgtcaccag tatgataatt tcccctacac ttttggccag      300

gggaccaaag tggatatcaa a                                                321



<210>  1182
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VL PRT

<400>  1182
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Phe Thr Phe Ile Ile Asn Asn Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Asp Asn Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  1183
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VH DNA

<400>  1183
caggttcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcga      300

tttttggagt ggttattcac gggaccattt gactactggg gccagggaac cctggtcacc      360

gtgtcctca                                                              369



<210>  1184
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VH PRT

<400>  1184
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Phe Leu Glu Trp Leu Phe Thr Gly Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  1185
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VH complete DNA

<400>  1185
caggttcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcga      300

tttttggagt ggttattcac gggaccattt gactactggg gccagggaac cctggtcacc      360

gtgtcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctccagtg      720

gccggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtgggc gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaacagctcc catcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga aaagcctctc cctgtccccg ggt                                  1353



<210>  1186
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VH complete PRT

<400>  1186
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Phe Leu Glu Trp Leu Phe Thr Gly Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  1187
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VL complete DNA

<400>  1187
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggaaagat ttcactttta tcatcaacaa cctgcagcct      240

gatgacattg caacatatta ctgtcaccag tatgataatt tcccctacac ttttggccag      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  1188
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A01 VL complete PRT

<400>  1188
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Phe Thr Phe Ile Ile Asn Asn Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Asp Asn Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1189
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 HCDR1 DNA

<400>  1189
agctatgcca tgagc                                                        15



<210>  1190
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 HCDR1 PRT

<400>  1190
Ser Tyr Ala Met Ser 
1               5   


<210>  1191
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 HCDR2 DNA

<400>  1191
gctattagtg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51



<210>  1192
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 HCDR2 PRT

<400>  1192
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  1193
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 HCDR3 DNA

<400>  1193
caccttgggg acggtgacta cgtcaattac tactactact acggtatgga cgtc             54



<210>  1194
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 HCDR3 PRT

<400>  1194
His Leu Gly Asp Gly Asp Tyr Val Asn Tyr Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  1195
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 LCDR1 DNA

<400>  1195
gggggaaaca acattggaag taaaaatgta cac                                    33



<210>  1196
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 LCDR1 PRT

<400>  1196
Gly Gly Asn Asn Ile Gly Ser Lys Asn Val His 
1               5                   10      


<210>  1197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 LCDR2 DNA

<400>  1197
gatgataacg tccggccctc a                                                 21



<210>  1198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 LCDR2 PRT

<400>  1198
Asp Asp Asn Val Arg Pro Ser 
1               5           


<210>  1199
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 LCDR3 DNA

<400>  1199
caggtgtggc ttaatagtag tgatgatgtg cta                                    33



<210>  1200
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 LCDR3 PRT

<400>  1200
Gln Val Trp Leu Asn Ser Ser Asp Asp Val Leu 
1               5                   10      


<210>  1201
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VL DNA

<400>  1201
tcctatgtgc tgactcagcc accctcggtg tcagtggccc cacgacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa aatgtacact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat aacgtccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg cttaatagta gtgatgatgt gctattcggc      300

ggaggcacca aggtgaccgt cctc                                             324



<210>  1202
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VL PRT

<400>  1202
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Arg Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Asn Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Leu Asn Ser Ser Asp Asp 
                85                  90                  95      


Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  1203
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VH DNA

<400>  1203
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttggc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacacctt      300

ggggacggtg actacgtcaa ttactactac tactacggta tggacgtctg gggccaaggg      360

accctggtca ccgtgtcctc a                                                381



<210>  1204
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VH PRT

<400>  1204
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Leu Gly Asp Gly Asp Tyr Val Asn Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  1205
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VH complete DNA

<400>  1205
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttggc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaacacctt      300

ggggacggtg actacgtcaa ttactactac tactacggta tggacgtctg gggccaaggg      360

accctggtca ccgtgtcctc agctagcacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctccag tggccggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg gcgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaacagct cccatccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaaaagcctc tccctgtccc cgggt                     1365



<210>  1206
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VH complete PRT

<400>  1206
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys His Leu Gly Asp Gly Asp Tyr Val Asn Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln 
                325                 330                 335     


Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  1207
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VL complete DNA

<400>  1207
tcctatgtgc tgactcagcc accctcggtg tcagtggccc cacgacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa aatgtacact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat aacgtccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg cttaatagta gtgatgatgt gctattcggc      300

ggaggcacca aggtgaccgt cctcggtcag cccaaggctg caccaagtgt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642



<210>  1208
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-A09 VL complete PRT

<400>  1208
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Arg Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Asn Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Leu Asn Ser Ser Asp Asp 
                85                  90                  95      


Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  1209
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 HCDR1 DNA

<400>  1209
agctatgcta tcagc                                                        15



<210>  1210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 HCDR1 PRT

<400>  1210
Ser Tyr Ala Ile Ser 
1               5   


<210>  1211
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 HCDR2 DNA

<400>  1211
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  1212
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 HCDR2 PRT

<400>  1212
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1213
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 HCDR3 DNA

<400>  1213
ccccgagtcc cccgagtctg ggagctctgg atcgggtttg gtgcttttga tatc             54



<210>  1214
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 HCDR3 PRT

<400>  1214
Pro Arg Val Pro Arg Val Trp Glu Leu Trp Ile Gly Phe Gly Ala Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  1215
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 LCDR1 DNA

<400>  1215
agggccagtc agagtgttag cagcagctac ttagcc                                 36



<210>  1216
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 LCDR1 PRT

<400>  1216
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  1217
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 LCDR2 DNA

<400>  1217
ggtgcatcca gcagggccac t                                                 21



<210>  1218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 LCDR2 PRT

<400>  1218
Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  1219
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 LCDR3 DNA

<400>  1219
cagcagtatg gtagctcacc ctacagt                                           27



<210>  1220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 LCDR3 PRT

<400>  1220
Gln Gln Tyr Gly Ser Ser Pro Tyr Ser 
1               5                   


<210>  1221
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VL DNA

<400>  1221
gaaatagtga tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccta cagttttggc      300

caggggacca agctggagat caaa                                             324



<210>  1222
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VL PRT

<400>  1222
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  1223
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VH DNA

<400>  1223
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggccccga      300

gtcccccgag tctgggagct ctggatcggg tttggtgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtgtcttc a                                                381



<210>  1224
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VH PRT

<400>  1224
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Pro Arg Val Trp Glu Leu Trp Ile Gly Phe Gly 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  1225
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VH complete DNA

<400>  1225
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaggccccga      300

gtcccccgag tctgggagct ctggatcggg tttggtgctt ttgatatctg gggccaaggg      360

acaatggtca ccgtgtcttc agctagcacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctccag tggccggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg gcgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgg gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaacagct cccatccccc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaaaagcctc tccctgtccc cgggt                     1365



<210>  1226
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VH complete PRT

<400>  1226
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Val Pro Arg Val Trp Glu Leu Trp Ile Gly Phe Gly 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln 
                325                 330                 335     


Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  1227
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VL complete DNA

<400>  1227
gaaatagtga tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccta cagttttggc      300

caggggacca agctggagat caaacgtacg gtggctgcac catctgtgtt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645



<210>  1228
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-B05 VL complete PRT

<400>  1228
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  1229
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 HCDR1 DNA

<400>  1229
agctatgcta tgcac                                                        15



<210>  1230
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 HCDR1 PRT

<400>  1230
Ser Tyr Ala Met His 
1               5   


<210>  1231
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 HCDR2 DNA

<400>  1231
gttatatcat atgatggaag caataaatac tacgcagact ccgtgaaggg c                51



<210>  1232
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 HCDR2 PRT

<400>  1232
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  1233
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 HCDR3 DNA

<400>  1233
gatcttttgg tgaac                                                        15



<210>  1234
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 HCDR3 PRT

<400>  1234
Asp Leu Leu Val Asn 
1               5   


<210>  1235
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 LCDR1 DNA

<400>  1235
cgggcgagtc agggcattag caattattta gcc                                    33



<210>  1236
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 LCDR1 PRT

<400>  1236
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  1237
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 LCDR2 DNA

<400>  1237
gctgcatcca ctttgcaatc a                                                 21



<210>  1238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 LCDR2 PRT

<400>  1238
Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  1239
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 LCDR3 DNA

<400>  1239
caaaagtata acagtgcccc ccggact                                           27



<210>  1240
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 LCDR3 PRT

<400>  1240
Gln Lys Tyr Asn Ser Ala Pro Arg Thr 
1               5                   


<210>  1241
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VL DNA

<400>  1241
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccccggac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321



<210>  1242
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VL PRT

<400>  1242
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  1243
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VH DNA

<400>  1243
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatctt      300

ttggtgaact ggggccaggg aaccctggtc accgtgtcct ca                         342



<210>  1244
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VH PRT

<400>  1244
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Val Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1245
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VH complete DNA

<400>  1245
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatctt      300

ttggtgaact ggggccaggg aaccctggtc accgtgtcct cagctagcac caagggccca      360

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc      540

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat      600

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact      660

cacacatgcc caccgtgccc agcacctcca gtggccggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

ggcgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg ggtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaacagc tcccatcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc     1320

ccgggt                                                                1326



<210>  1246
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VH complete PRT

<400>  1246
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Val Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440         


<210>  1247
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VL complete DNA

<400>  1247
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccccggac tttcggcgga      300

gggaccaaag tggatatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  1248
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-C01 VL complete PRT

<400>  1248
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1249
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 HCDR1 DNA

<400>  1249
agctatgcta tcagc                                                        15



<210>  1250
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 HCDR1 PRT

<400>  1250
Ser Tyr Ala Ile Ser 
1               5   


<210>  1251
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 HCDR2 DNA

<400>  1251
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  1252
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 HCDR2 PRT

<400>  1252
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1253
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 HCDR3 DNA

<400>  1253
ggtgggagct acttgccctt tgactac                                           27



<210>  1254
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 HCDR3 PRT

<400>  1254
Gly Gly Ser Tyr Leu Pro Phe Asp Tyr 
1               5                   


<210>  1255
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 LCDR1 DNA

<400>  1255
agggccagtc agagtgttag cagctactta gcc                                    33



<210>  1256
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 LCDR1 PRT

<400>  1256
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  1257
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 LCDR2 DNA

<400>  1257
gatgcatcca acagggccac t                                                 21



<210>  1258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 LCDR2 PRT

<400>  1258
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  1259
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 LCDR3 DNA

<400>  1259
cagcaacgta gcaactggcc tccgact                                           27



<210>  1260
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 LCDR3 PRT

<400>  1260
Gln Gln Arg Ser Asn Trp Pro Pro Thr 
1               5                   


<210>  1261
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VL DNA

<400>  1261
gaaatagtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg ccgtttatta ctgtcagcaa cgtagcaact ggcctccgac tttcggcgga      300

gggaccaagc tggagatcaa a                                                321



<210>  1262
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VL PRT

<400>  1262
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1263
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VH DNA

<400>  1263
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggtggg      300

agctacttgc cctttgacta ctggggccag ggaaccctgg tcaccgtgtc ctca            354



<210>  1264
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VH PRT

<400>  1264
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Tyr Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  1265
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VH complete DNA

<400>  1265
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggtggg      300

agctacttgc cctttgacta ctggggccag ggaaccctgg tcaccgtgtc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctc cagtggccgg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tgggcgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaaca gctcccatcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaaaagc     1320

ctctccctgt ccccgggt                                                   1338



<210>  1266
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VH complete PRT

<400>  1266
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Tyr Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  1267
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VL complete DNA

<400>  1267
gaaatagtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg ccgtttatta ctgtcagcaa cgtagcaact ggcctccgac tttcggcgga      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  1268
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E03 VL complete PRT

<400>  1268
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1269
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 HCDR1 DNA

<400>  1269
agctatgcta tcagc                                                        15



<210>  1270
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 HCDR1 PRT

<400>  1270
Ser Tyr Ala Ile Ser 
1               5   


<210>  1271
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 HCDR2 DNA

<400>  1271
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51



<210>  1272
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 HCDR2 PRT

<400>  1272
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      



<210>  1273
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 HCDR3 DNA

<400>  1273
gatttgtaca gctatggccc ctggtactac tttgactac                              39



<210>  1274
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 HCDR3 PRT

<400>  1274
Asp Leu Tyr Ser Tyr Gly Pro Trp Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  1275
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 LCDR1 DNA

<400>  1275
cgggcaagtc agagcattga caactattta aat                                    33



<210>  1276
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 LCDR1 PRT

<400>  1276
Arg Ala Ser Gln Ser Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  1277
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 LCDR2 DNA

<400>  1277
actgcatcca gtttgcaaag t                                                 21



<210>  1278
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 LCDR2 PRT

<400>  1278
Thr Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1279
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 LCDR3 DNA

<400>  1279
caacagagtt acaatacccc tcccact                                           27



<210>  1280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 LCDR3 PRT

<400>  1280
Gln Gln Ser Tyr Asn Thr Pro Pro Thr 
1               5                   


<210>  1281
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VL DNA

<400>  1281
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattgac aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgccaacag agttacaata cccctcccac tttcggccct      300

gggaccaagg tggaaatcaa a                                                321



<210>  1282
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VL PRT

<400>  1282
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1283
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VH DNA

<400>  1283
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatttg      300

tacagctatg gcccctggta ctactttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctca                                                                 366



<210>  1284
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VH PRT

<400>  1284
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ser Tyr Gly Pro Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  1285
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VH complete DNA

<400>  1285
caggttcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatttg      300

tacagctatg gcccctggta ctactttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tccagtggcc      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtgggcgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa cagctcccat cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaaa gcctctccct gtccccgggt                                      1350



<210>  1286
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VH complete PRT

<400>  1286
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ser Tyr Gly Pro Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  1287
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VL complete DNA

<400>  1287
gacatcgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattgac aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgccaacag agttacaata cccctcccac tttcggccct      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  1288
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YU519-E12 VL complete PRT

<400>  1288
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1289
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  PHE162-D2

<400>  1289

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Leu Asn Asn Trp Lys Thr Gln Pro Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  1290
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH PHE162-D2

<400>  1290

Gly Ser Ser Ile Ser Ser Gly Gly Tyr Tyr 
1               5                   10  


<210>  1291
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH PHE162-D2

<400>  1291

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  1292
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH PHE162-D2

<400>  1292

Ala Arg Arg Leu Asn Asn Trp Lys Thr Gln Pro Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  1293
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL PHE162-D2

<400>  1293

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Pro Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1294
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL PHE162-D2

<400>  1294

Ser Pro Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  1295
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL PHE162-D2

<400>  1295

Gly Asn Ser 
1           


<210>  1296
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL PHE162-D2

<400>  1296

Gln Ser Tyr Asp Ser Ser Leu Ser Asp Val Val 
1               5                   10      


<210>  1297
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-A10

<400>  1297

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1298
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-A10

<400>  1298

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1299
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-A10

<400>  1299

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1300
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-A10

<400>  1300

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1301
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-A10

<400>  1301

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr His Cys Gln Gln Tyr Asn Ser Tyr Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1302
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 STE90-A10

<400>  1302

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  1303
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-A10

<400>  1303

Lys Ala Ser 
1           


<210>  1304
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-A10

<400>  1304

Gln Gln Tyr Asn Ser Tyr Pro Val Thr 
1               5                   


<210>  1305
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-C11

<400>  1305

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1306
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-C11

<400>  1306

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1307
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-C11

<400>  1307

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1308
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-C11

<400>  1308

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1309
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-C11

<400>  1309

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  1310
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-C11

<400>  1310

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1311
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-C11

<400>  1311

Ala Ala Ser 
1           


<210>  1312
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-C11

<400>  1312

Gln Gln Leu Asn Ser Tyr Pro Pro Phe Thr 
1               5                   10  


<210>  1313
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-D7

<400>  1313

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1314
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-D7

<400>  1314

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1315
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-D7

<400>  1315

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1316
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-D7

<400>  1316

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1317
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-D7

<400>  1317

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  1318
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-D7

<400>  1318

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  1319
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-D7

<400>  1319

Ala Ala Ser 
1           


<210>  1320
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-D7

<400>  1320

Gln Gln Ala Asn Ser Leu Pro Leu Thr 
1               5                   


<210>  1321
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-G2

<400>  1321

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1322
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-G2

<400>  1322

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1323
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-G2

<400>  1323

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1324
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-G2

<400>  1324

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1325
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-G2

<400>  1325

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210>  1326
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-G2

<400>  1326

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  1327
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-G2

<400>  1327

Ala Ala Ser 
1           


<210>  1328
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-G2

<400>  1328

Gln Gln Ala Asn Ser Phe Pro Pro Leu Phe Thr 
1               5                   10      


<210>  1329
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B1-A10

<400>  1329

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1330
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B1-A10

<400>  1330

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1331
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B1-A10

<400>  1331

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1332
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B1-A10

<400>  1332

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1333
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B1-A10

<400>  1333

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1334
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B1-A10

<400>  1334

Gln Ser Ile Gly Ser Trp 
1               5       


<210>  1335
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B1-A10

<400>  1335

Lys Ala Ser 
1           


<210>  1336
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B1-A10

<400>  1336

Gln Gln Tyr Asn Ser Tyr Pro Val Thr 
1               5                   


<210>  1337
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B1-B4

<400>  1337

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1338
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B1-B4

<400>  1338

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1339
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B1-B4

<400>  1339

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1340
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B1-B4

<400>  1340

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1341
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B1-B4

<400>  1341

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 
            100                 105         


<210>  1342
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B1-B4

<400>  1342

Gln Ser Ile Ser Thr Tyr 
1               5       


<210>  1343
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B1-B4

<400>  1343

Gly Ala Ser 
1           


<210>  1344
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B1-B4

<400>  1344

Gln Gln Ser Tyr Asn Thr Pro Leu Thr 
1               5                   


<210>  1345
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B1-D1

<400>  1345

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1346
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B1-D1

<400>  1346

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1347
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B1-D1

<400>  1347

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1348
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B1-D1

<400>  1348

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1349
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B1-D1

<400>  1349

Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  1350
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B1-D1

<400>  1350

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1351
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B1-D1

<400>  1351

Ala Ala Ser 
1           


<210>  1352
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B1-D1

<400>  1352

Gln Gln Leu Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  1353
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B1-D6

<400>  1353

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Leu Val Gly Ala Thr Thr Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1354
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B1-D6

<400>  1354

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1355
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B1-D6

<400>  1355

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1356
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B1-D6

<400>  1356

Ala Arg Glu Gly Leu Val Gly Ala Thr Thr Ala Phe Asp Tyr 
1               5                   10                  


<210>  1357
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B1-D6

<400>  1357

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Met Pro Pro 
                85                  90                  95      


Ser Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  1358
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B1-D6

<400>  1358

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1359
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B1-D6

<400>  1359

Ala Ala Ser 
1           


<210>  1360
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B1-D6

<400>  1360

Gln Gln Ser Tyr Ser Met Pro Pro Ser Thr 
1               5                   10  


<210>  1361
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B1-F8

<400>  1361

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Leu Val Gly Ala Thr Thr Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1362
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B1-F8

<400>  1362

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1363
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD2 VH STE90-B1-F8

<400>  1363

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1364
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B1-F8

<400>  1364

Ala Arg Glu Gly Leu Val Gly Ala Thr Thr Ala Phe Asp Tyr 
1               5                   10                  


<210>  1365
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B1-F8

<400>  1365

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  1366
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B1-F8

<400>  1366

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1367
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B1-F8

<400>  1367

Ala Ala Ser 
1           


<210>  1368
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B1-F8

<400>  1368

Gln Gln Ser Tyr Ser Thr Pro Pro Val Thr 
1               5                   10  


<210>  1369
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B2-A1

<400>  1369

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1370
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B2-A1

<400>  1370

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1371
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B2-A1

<400>  1371

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1372
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B2-A1

<400>  1372

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1373
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B2-A1

<400>  1373

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Asp Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Leu Glu Ile Lys 
            100             


<210>  1374
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B2-A1

<400>  1374

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1375
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B2-A1

<400>  1375

Ala Ala Ser 
1           


<210>  1376
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B2-A1

<400>  1376

Gln Gln Arg Asp Thr 
1               5   


<210>  1377
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B2-B3

<400>  1377

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1378
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B2-B3

<400>  1378

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1379
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B2-B3

<400>  1379

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1380
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B2-B3

<400>  1380

Ala Arg Asp Val Ala Asp Val Phe Asp Ile 
1               5                   10  


<210>  1381
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B2-B3

<400>  1381

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1382
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B2-B3

<400>  1382

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  1383
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B2-B3

<400>  1383

Lys Ala Ser 
1           


<210>  1384
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B2-B3

<400>  1384

Gln Gln Tyr Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  1385
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B2-C5

<400>  1385

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1386
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B2-C5

<400>  1386

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1387
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B2-C5

<400>  1387

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1388
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B2-C5

<400>  1388

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1389
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B2-C5

<400>  1389

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1390
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B2-C5

<400>  1390

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  1391
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B2-C5

<400>  1391

Lys Ala Ser 
1           


<210>  1392
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B2-C5

<400>  1392

Gln Gln Tyr Asn Ser Tyr Pro Val Thr 
1               5                   


<210>  1393
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B2-D12

<400>  1393

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1394
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLTVSSNY

<400>  1394

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1395
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B2-D12

<400>  1395

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1396
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B2-D12

<400>  1396

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1397
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B2-D12

<400>  1397

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  1398
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B2-D12

<400>  1398

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1399
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B2-D12

<400>  1399

Ala Ala Ser 
1           


<210>  1400
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B2-D12

<400>  1400

Gln Gln Leu Asn Ser Tyr Pro Pro Tyr Thr 
1               5                   10  


<210>  1401
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B2-E6

<400>  1401

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1402
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B2-E6

<400>  1402

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1403
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B2-E6

<400>  1403

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1404
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B2-E6

<400>  1404

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1405
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B2-E6

<400>  1405

Ala Ile Arg Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Ala Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  1406
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B2-E6

<400>  1406

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1407
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B2-E6

<400>  1407

Ala Ala Ser 
1           


<210>  1408
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B2-E6

<400>  1408

Gln Gln Leu Asn Ser Tyr Pro Pro Ala 
1               5                   


<210>  1409
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B3-B10

<400>  1409

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1410
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B3-B10

<400>  1410

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1411
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B3-B10

<400>  1411

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1412
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B3-B10

<400>  1412

Ala Arg Asp Val Ala Asp Ala Phe Asp Val 
1               5                   10  


<210>  1413
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B3-B10

<400>  1413

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1414
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B3-B10

<400>  1414

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  1415
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B3-B10

<400>  1415

Lys Ala Ser 
1           


<210>  1416
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B3-B10

<400>  1416

Gln Gln Tyr Asn Ser Tyr Pro Val Thr 
1               5                   


<210>  1417
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B3-H3

<400>  1417

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1418
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B3-H3

<400>  1418

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1419
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B3-H3

<400>  1419

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1420
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE90-B3-H3

<400>  1420

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1421
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B3-H3

<400>  1421

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Leu Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210>  1422
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B3-H3

<400>  1422

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  1423
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B3-H3

<400>  1423

Ala Ala Ser 
1           


<210>  1424
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B3-H3

<400>  1424

Gln Gln Ala Asn Ser Phe Pro Pro Leu Phe Thr 
1               5                   10      


<210>  1425
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE90-B3-H6

<400>  1425

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1426
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B3-H6

<400>  1426

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1427
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE90-B3-H6

<400>  1427

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1428
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE90-B3-H6

<400>  1428

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1429
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE90-B3-H6

<400>  1429

Ala Ile Arg Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  1430
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE90-B3-H6

<400>  1430

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1431
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE90-B3-H6

<400>  1431

Ala Ala Ser 
1           


<210>  1432
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE90-B3-H6

<400>  1432

Gln Gln Leu Asn Ser Tyr Pro Pro Trp Thr 
1               5                   10  


<210>  1433
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE91-C4

<400>  1433

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1434
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE91-C4

<400>  1434

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1435
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE91-C4

<400>  1435

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1436
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE91-C4

<400>  1436

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1437
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE91-C4

<400>  1437

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Thr 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ala Glu Asp Thr Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ala Gly Gln Ala Pro Val Leu Val Ile Phe 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Lys Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser Tyr Thr Asp Ala 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  1438
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE91-C4

<400>  1438

Thr Ile Gly Ser Lys Ser 
1               5       


<210>  1439
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE91-C4

<400>  1439

Tyr Asp Ser 
1           


<210>  1440
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE91-C4

<400>  1440

Gln Val Trp Asp Ser Tyr Thr Asp Ala Val Val 
1               5                   10      


<210>  1441
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE91-D4

<400>  1441

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1442
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE91-D4

<400>  1442

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1443
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE91-D4

<400>  1443

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1444
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE91-D4

<400>  1444

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1445
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE91-D4

<400>  1445

Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Tyr Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Phe Ala Phe Tyr 
                85                  90                  95      


Ile Phe Gly Thr Gly Thr Arg Val Thr Val Leu 
            100                 105         


<210>  1446
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE91-D4

<400>  1446

Lys Leu Gly Asp Lys Tyr 
1               5       


<210>  1447
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE91-D4

<400>  1447

Gln Asp Thr 
1           


<210>  1448
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE91-D4

<400>  1448

Gln Ala Trp Asp Ser Phe Ala Phe Tyr Ile 
1               5                   10  


<210>  1449
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE91-F6

<400>  1449

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1450
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE91-F6

<400>  1450

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1451
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE91-F6

<400>  1451

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1452
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE91-F6

<400>  1452

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1453
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE91-F6

<400>  1453

Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Gly Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  1454
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE91-F6

<400>  1454

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  1455
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE91-F6

<400>  1455

Gly Asn Ser 
1           


<210>  1456
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE91-F6

<400>  1456

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Gly Val 
1               5                   10          


<210>  1457
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE91-F10

<400>  1457

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1458
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE91-F10

<400>  1458

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1459
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE91-F10

<400>  1459

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1460
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE91-F10

<400>  1460

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1461
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE91-F10

<400>  1461

Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Ile Ala Ser Ile Thr Cys Ser Gly Tyr Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Gly Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Phe Ala Phe Tyr 
                85                  90                  95      


Val Phe Gly Thr Gly Thr Arg Val Thr Val Leu 
            100                 105         


<210>  1462
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE91-F10

<400>  1462

Lys Leu Gly Asp Lys Tyr 
1               5       


<210>  1463
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE91-F10

<400>  1463

Gln Gly Thr 
1           


<210>  1464
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE91-F10

<400>  1464

Gln Ala Trp Asp Ser Phe Ala Phe Tyr Val 
1               5                   10  


<210>  1465
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE91-B1-A10

<400>  1465

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1466
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE91-B1-A10

<400>  1466

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1467
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE91-B1-A10

<400>  1467

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1468
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE91-B1-A10

<400>  1468

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1469
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE91-B1-A10

<400>  1469

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Tyr Lys Leu Gly Asp Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Phe Ala Phe Tyr 
                85                  90                  95      


Val Phe Gly Thr Gly Thr Arg Val Thr Val Leu 
            100                 105         


<210>  1470
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE91-B1-A10

<400>  1470

Lys Leu Gly Asp Lys Tyr 
1               5       


<210>  1471
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE91-B1-A10

<400>  1471

Gln Asp Thr 
1           


<210>  1472
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE91-B1-A10

<400>  1472

Gln Ala Trp Asp Ser Phe Ala Phe Tyr Val 
1               5                   10  


<210>  1473
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE91-B1-B3

<400>  1473

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1474
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE91-B1-B3

<400>  1474

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1475
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE91-B1-B3

<400>  1475

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1476
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE91-B1-B3

<400>  1476

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1477
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE91-B1-B3

<400>  1477

Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  1478
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE91-B1-B3

<400>  1478

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  1479
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE91-B1-B3

<400>  1479

Asp Asp Ser 
1           


<210>  1480
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE91-B1-B3

<400>  1480

Gln Val Trp Asp Ser Ser Ser Asp His Tyr Val 
1               5                   10      


<210>  1481
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-A1

<400>  1481

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1482
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-A1

<400>  1482

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1483
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-A1

<400>  1483

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1484
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-A1

<400>  1484

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1485
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-A1

<400>  1485

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1486
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-A1

<400>  1486

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  1487
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-A1

<400>  1487

Gly Asn Ser 
1           


<210>  1488
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-A1

<400>  1488

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Leu Val 
1               5                   10      


<210>  1489
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-B2

<400>  1489

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1490
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-B2

<400>  1490

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1491
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-B2

<400>  1491

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1492
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-B2

<400>  1492

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1493
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-B2

<400>  1493

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Asn Asp Arg Pro Ser Arg Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asp Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  1494
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-B2

<400>  1494

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  1495
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-B2

<400>  1495

Asp Asp Asn 
1           


<210>  1496
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-B2

<400>  1496

Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  1497
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-D3

<400>  1497

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1498
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-D3

<400>  1498

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1499
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-D3

<400>  1499

Ile Tyr Ser Gly Gly Ser Thr 
1               5   
          

<210>  1500
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-D3

<400>  1500

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1501
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-D3

<400>  1501

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ala Ala 
            20                  25                  30          


Asn Tyr Val Phe Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Gly Tyr Leu Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1502
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-D3

<400>  1502

Ser Asn Asp Val Gly Ala Ala Asn Tyr 
1               5                   


<210>  1503
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-D3

<400>  1503

Gly Val Ser 
1           


<210>  1504
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-D3

<400>  1504

Ser Ser Tyr Thr Ser Ser Gly Tyr Leu Gly Val 
1               5                   10      


<210>  1505
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-E3

<400>  1505

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1506
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-E3

<400>  1506

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1507
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-E3

<400>  1507

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1508
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-E3

<400>  1508

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1509
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-E3

<400>  1509

Asp Ile Arg Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Arg 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1510
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-E3

<400>  1510

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1511
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-E3

<400>  1511

Ala Ala Ser 
1           


<210>  1512
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-E3

<400>  1512

Gln Gln Leu Asn Ser Tyr Pro Arg Ser 
1               5                   


<210>  1513
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-E9

<400>  1513

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1514
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-E9

<400>  1514

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1515
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-E9

<400>  1515

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1516
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-E9

<400>  1516

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1517
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-E9

<400>  1517

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Ser Ala Gly Ser Asn 
                85                  90                  95      


Asn Leu Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  1518
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-E9

<400>  1518

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  1519
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-E9

<400>  1519

Arg Asn Asn 
1           


<210>  1520
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-E9

<400>  1520

Ser Ser Ser Ala Gly Ser Asn Asn Leu Leu 
1               5                   10  


<210>  1521
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-F6

<400>  1521

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Val Gly Asp Tyr Tyr Tyr Asp Ser Ser Gly Tyr Ser Pro 
            100                 105                 110         


Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  1522
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-F6

<400>  1522

Gly Gly Thr Phe Asn Asn Tyr Ala 
1               5               


<210>  1523
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-F6

<400>  1523

Ile Ile Pro Ile Leu Gly Ile Ala 
1               5               


<210>  1524
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-F6

<400>  1524

Ala Thr Ala Val Gly Asp Tyr Tyr Tyr Asp Ser Ser Gly Tyr Ser Pro 
1               5                   10                  15      


Asn Trp Phe Asp Pro 
            20      


<210>  1525
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-F6

<400>  1525

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  1526
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-F6

<400>  1526

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1527
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-F6

<400>  1527

Ala Ala Ser 
1           


<210>  1528
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-F6

<400>  1528

Gln Gln Ser Tyr Ser Thr Leu Tyr Thr 
1               5                   


<210>  1529
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-F7

<400>  1529

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1530
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-F7

<400>  1530

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1531
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-F7

<400>  1531

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1532
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-F7

<400>  1532

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1533
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-F7

<400>  1533

Gln Ala Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu 
                85                  90                  95      


Ser Gly Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  1534
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-F7

<400>  1534

Ser Ser Asn Leu Gly Ser Asn Tyr 
1               5               


<210>  1535
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-F7

<400>  1535

Arg Asn Tyr 
1           


<210>  1536
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-F7

<400>  1536

Ala Ala Trp Asp Gly Ser Leu Ser Gly Val Leu 
1               5                   10      


<210>  1537
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-F12

<400>  1537

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1538
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-F12

<400>  1538

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1539
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-F12

<400>  1539

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1540
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-F12

<400>  1540

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1541
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-F12

<400>  1541

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Ile Cys Gly Gly Asn Asn Val Gly Ser Thr Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asn Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Thr Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr His Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  1542
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-F12

<400>  1542

Asn Asn Val Gly Ser Thr Ser 
1               5           


<210>  1543
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-F12

<400>  1543

Asp Asn Ser 
1           


<210>  1544
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-F12

<400>  1544

Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  1545
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-H2

<400>  1545

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1546
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-H2

<400>  1546

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1547
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-H2

<400>  1547

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1548
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-H2

<400>  1548

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1549
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-H2

<400>  1549

Asp Ile Arg Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  1550
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-H2

<400>  1550

Gln Gly Ile Ser Ser Tyr 
1               5       


<210>  1551
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-H2

<400>  1551

Ala Ala Ser 
1           


<210>  1552
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-H2

<400>  1552

Gln Gln Leu Asn Ser Tyr Pro Pro Tyr Thr 
1               5                   10  


<210>  1553
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-B1-D1

<400>  1553

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1554
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-B1-D1

<400>  1554

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1555
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-B1-D1

<400>  1555

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1556
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-B1-D1

<400>  1556

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1557
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-B1-D1

<400>  1557

Leu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Gly Gly Asp Tyr Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Glu Trp Pro Pro Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Pro Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Glu Ser Gly Ser Asp His 
                85                  90                  95      


Tyr Val Phe Gly Ser Gly Thr Lys Val Ala Val Leu 
            100                 105             


<210>  1558
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-B1-D1

<400>  1558

Tyr Ile Gly Ser Lys Ser 
1               5       


<210>  1559
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-B1-D1

<400>  1559

Asp Asp Ser 
1           


<210>  1560
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-B1-D1

<400>  1560

Gln Val Trp Glu Ser Gly Ser Asp His Tyr Val 
1               5                   10      


<210>  1561
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-B1-E12

<400>  1561

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1562
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-B1-E12

<400>  1562

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1563
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-B1-E12

<400>  1563

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1564
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-B1-E12

<400>  1564

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1565
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-B1-E12

<400>  1565

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Ile Ala Lys Ile Thr Cys Ser Gly Asp Asn Leu Gly Asp Lys Asn Val 
            20                  25                  30          


Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Gln Asp Leu Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Thr Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ile Ser Thr Ser Thr 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  1566
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-B1-E12

<400>  1566

Asn Leu Gly Asp Lys Asn 
1               5       


<210>  1567
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-B1-E12

<400>  1567

Gln Asp Leu 
1           


<210>  1568
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-B1-E12

<400>  1568

Gln Ala Trp Asp Ile Ser Thr Ser Thr Tyr Val 
1               5                   10      


<210>  1569
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-B2-B1

<400>  1569

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1570
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-B2-B1

<400>  1570

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1571
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-B2-B1

<400>  1571

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1572
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-B2-B1

<400>  1572

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1573
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-B2-B1

<400>  1573

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Leu Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1574
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-B2-B1

<400>  1574

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  1575
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-B2-B1

<400>  1575

Gly Asn Ser 
1           


<210>  1576
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-B2-B1

<400>  1576

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  1577
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-B2-B6

<400>  1577

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1578
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-B2-B6

<400>  1578

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1579
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-B2-B6

<400>  1579

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1580
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-B2-B6

<400>  1580

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1581
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-B2-B6

<400>  1581

Asp Val Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


His Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  1582
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-B2-B6

<400>  1582

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  1583
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-B2-B6

<400>  1583

Ala Ala Ser 
1           


<210>  1584
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-B2-B6

<400>  1584

Gln Gln Ser Tyr Ser Thr Pro Pro His Thr 
1               5                   10  


<210>  1585
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE94-B2-E11

<400>  1585

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1586
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE94-B2-E11

<400>  1586

Gly Leu Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1587
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE94-B2-E11

<400>  1587

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1588
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE94-B2-E11

<400>  1588

Ala Arg Asp Val Ala Asp Ala Phe Asp Ile 
1               5                   10  


<210>  1589
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE94-B2-E11

<400>  1589

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Thr Tyr Tyr Cys Gly Thr Trp Asp Ser Ser 
                85                  90                  95      


Leu Ile Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1590
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE94-B2-E11

<400>  1590

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  1591
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE94-B2-E11

<400>  1591

Asp Asn Asn 
1           


<210>  1592
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE94-B2-E11

<400>  1592

Gly Thr Trp Asp Ser Ser Leu Ile Gly Val Val 
1               5                   10      


<210>  1593
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE70-1E12

<400>  1593

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Gly Tyr Asn Phe Asn Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1594
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE70-1E12

<400>  1594

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  1595
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE70-1E12

<400>  1595

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  1596
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE70-1E12

<400>  1596

Val Arg Asp Gly Tyr Asn Phe Asn Asn Trp Phe Asp Pro 
1               5                   10              


<210>  1597
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE70-1E12

<400>  1597

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ile Thr Ile Ser Cys Thr Gly Ser Gly Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Arg Gln Arg Pro Gly Ser Ala Pro Thr Ile Val 
        35                  40                  45              


Ile Tyr Glu Asp Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Glu Ser 
                85                  90                  95      


Thr Asn His Val Met Phe Gly Gly Gly Ser Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1598
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE70-1E12

<400>  1598

Gly Gly Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  1599
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE70-1E12

<400>  1599

Glu Asp Thr 
1           


<210>  1600
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE70-1E12

<400>  1600

Gln Ser Ser Glu Ser Thr Asn His Val Met 
1               5                   10  


<210>  1601
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-1B6

<400>  1601

Gln Val Lys Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Pro Tyr Gly Asp Phe Arg Gly Leu Trp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  1602
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-1B6

<400>  1602

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1603
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-1B6

<400>  1603

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  1604
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-1B6

<400>  1604

Ala Lys Ala Pro Tyr Gly Asp Phe Arg Gly Leu Trp Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  1605
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-1B6

<400>  1605

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asp Ser Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Gln 
            100                 105         


<210>  1606
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-1B6

<400>  1606

Gln Asp Ile Arg Ser Trp 
1               5       


<210>  1607
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-1B6

<400>  1607

Asp Ala Ser 
1           


<210>  1608
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-1B6

<400>  1608

Gln Gln Ala Asp Ser Val Pro Leu Thr 
1               5                   


<210>  1609
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-1G5

<400>  1609

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Gly Val Gln Leu Trp Leu Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  1610
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-1G5

<400>  1610

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1611
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-1G5

<400>  1611

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  1612
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-1G5

<400>  1612

Ala Val Gly Gly Val Gln Leu Trp Leu Thr Tyr 
1               5                   10      


<210>  1613
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-1G5

<400>  1613

Glu Thr Thr Leu Thr Gln Ser Pro Gly Ala Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Val Ser Gln Ser Leu Ser Ser Asn 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Thr Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Lys Tyr Gly Ser Trp Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val 
            100                 105         


<210>  1614
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-1G5

<400>  1614

Gln Ser Leu Ser Ser Asn Ser 
1               5           


<210>  1615
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-1G5

<400>  1615

Asp Thr Ser 
1           


<210>  1616
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-1G5

<400>  1616

His Lys Tyr Gly Ser Trp Pro Arg Thr 
1               5                   


<210>  1617
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-4C10

<400>  1617

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ser Ser Ser Trp Tyr Gly Leu Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  1618
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-4C10

<400>  1618

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1619
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-4C10

<400>  1619

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  1620
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-4C10

<400>  1620

Ala Arg Glu Tyr Ser Ser Ser Trp Tyr Gly Leu Gly Ala Phe Asp Ile 
1               5                   10                  15      


<210>  1621
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-4C10

<400>  1621

Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile His Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Ser Leu Leu Val 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Phe Lys Ser Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  1622
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-4C10

<400>  1622

Gln Asn Ile His Tyr Tyr 
1               5       


<210>  1623
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-4C10

<400>  1623

Gly Ala Ser 
1           


<210>  1624
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-4C10

<400>  1624

Gln Gln Ser Phe Lys Ser Pro Ala Thr 
1               5                   


<210>  1625
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-4E12

<400>  1625

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  1626
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-4E12

<400>  1626

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  1627
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-4E12

<400>  1627

Ile Asn Pro Ser Gly Gly Ser Thr 
1               5               


<210>  1628
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-4E12

<400>  1628

Ala Arg Asp Leu Ser Gly Gly Leu Asp Tyr 
1               5                   10  


<210>  1629
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-4E12

<400>  1629

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ala Cys Arg Ala Gly Gln Thr Ile Ser Ser Lys 
            20                  25                  30          


Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asp Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1630
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-4E12

<400>  1630

Gln Thr Ile Ser Ser Lys 
1               5       


<210>  1631
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-4E12

<400>  1631

Asp Ala Ser 
1           


<210>  1632
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-4E12

<400>  1632

Gln Gln Tyr Ser Asp Trp Pro Pro Thr 
1               5                   


<210>  1633
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-8A2

<400>  1633

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Phe Tyr Asp Ser Ser Gly Tyr Ser Thr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1634
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-8A2

<400>  1634

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  1635
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-8A2

<400>  1635

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  1636
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-8A2

<400>  1636

Ala Arg Phe Phe Tyr Asp Ser Ser Gly Tyr Ser Thr Asp Tyr 
1               5                   10                  


<210>  1637
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-8A2

<400>  1637

Asp Ile Arg Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1638
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-8A2

<400>  1638

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  1639
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-8A2

<400>  1639

Asp Ala Ser 
1           


<210>  1640
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-8A2

<400>  1640

Gln Gln Tyr Asp Asn Leu Pro Arg Thr 
1               5                   


<210>  1641
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-8A6

<400>  1641

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Phe Tyr Asp Ser Ser Gly Tyr Ser Thr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1642
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-8A6

<400>  1642

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  1643
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-8A6

<400>  1643

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  1644
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-8A6

<400>  1644

Ala Arg Phe Phe Tyr Asp Ser Ser Gly Tyr Ser Thr Asp Tyr 
1               5                   10                  


<210>  1645
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-8A6

<400>  1645

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Leu Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  1646
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-8A6

<400>  1646

Gln Asn Ile Gly Thr Trp 
1               5       


<210>  1647
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-8A6

<400>  1647

Lys Ala Ser 
1           


<210>  1648
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-8A6

<400>  1648

Gln Gln Tyr Asp Ser Tyr Leu Phe Thr 
1               5                   


<210>  1649
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-8E1

<400>  1649

Gln Val Gln Leu Gln Glu Trp Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Ile Tyr Pro Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Pro Lys Arg Ser Gly Ser Pro Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  1650
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-8E1

<400>  1650

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr 
1               5                   10  


<210>  1651
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-8E1

<400>  1651

Ile Tyr Pro Ser Gly Ser Thr 
1               5           


<210>  1652
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-8E1

<400>  1652

Ala Arg Gly Gly Pro Lys Arg Ser Gly Ser Pro Phe Asp Val 
1               5                   10                  


<210>  1653
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-8E1

<400>  1653

Glu Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Phe Gly Pro Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Met Ala Ser Glu Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Phe Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  1654
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-8E1

<400>  1654

Gln Thr Phe Gly Pro Trp 
1               5       


<210>  1655
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-8E1

<400>  1655

Met Ala Ser 
1           


<210>  1656
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-8E1

<400>  1656

Gln Gln Tyr Asn Thr Phe Ser Pro Trp Thr 
1               5                   10  


<210>  1657
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE72-2G4

<400>  1657

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Phe Tyr Asp Ser Ser Gly Tyr Ser Thr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  1658
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE72-2G4

<400>  1658

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  1659
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE72-2G4

<400>  1659

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  1660
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE72-2G4

<400>  1660

Ala Arg Phe Phe Tyr Asp Ser Ser Gly Tyr Ser Thr Asp Tyr 
1               5                   10                  


<210>  1661
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE72-2G4

<400>  1661

Glu Thr Thr Leu Thr Gln Ser Pro Ala Phe Met Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser His 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Gly Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Trp Pro Pro 
                85                  90                  95      


Gly Tyr Asn Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  1662
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE72-2G4

<400>  1662

Gln Ser Val Asp Ser His 
1               5       


<210>  1663
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE72-2G4

<400>  1663

Gly Ala Ser 
1           


<210>  1664
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE72-2G4

<400>  1664

Gln Gln Tyr Ala Ser Trp Pro Pro Gly Tyr Asn 
1               5                   10      


<210>  1665
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-2B2

<400>  1665

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Ser Gly Trp Tyr Phe Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  1666
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-2B2

<400>  1666

Gly Tyr Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  1667
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-2B2

<400>  1667

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  1668
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-2B2

<400>  1668

Ala Arg Val Ser Gly Trp Tyr Phe Gly Ala Phe Asp Ile 
1               5                   10              


<210>  1669
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-2B2

<400>  1669

Leu Pro Val Leu Thr Gln Pro His Ser Leu Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Asn Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Ser Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Asn Gln Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  1670
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-2B2

<400>  1670

Ser Gly Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  1671
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-2B2

<400>  1671

Glu Asp Ser 
1           


<210>  1672
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-2B2

<400>  1672

Gln Ser Tyr Asp Ser Ser Asn Asn Gln Trp Val 
1               5                   10      


<210>  1673
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-2C2

<400>  1673

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly His Asp Asn Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  1674
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-2C2

<400>  1674

Gly Ile Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1675
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-2C2

<400>  1675

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  1676
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-2C2

<400>  1676

Ala Arg Gly His Asp Asn Leu Asp Tyr 
1               5                   


<210>  1677
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-2C2

<400>  1677

Leu Pro Val Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Ile Ile Ser Cys Thr Gly Ser Ser Asp Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Thr Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Glu Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Asn Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  1678
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-2C2

<400>  1678

Ser Asp Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  1679
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-2C2

<400>  1679

Glu Asp Asn 
1           


<210>  1680
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-2C2

<400>  1680

Gln Ser Tyr Asp Ser Asn Asn His Trp Val 
1               5                   10  


<210>  1681
<211>  114
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-2E9

<400>  1681

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  1682
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-2E9

<400>  1682

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  1683
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-2E9

<400>  1683

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  1684
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-2E9

<400>  1684

Ala Arg Gly Lys Phe Asp Tyr 
1               5           


<210>  1685
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-2E9

<400>  1685

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Ser Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Val Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  1686
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-2E9

<400>  1686

Ser Ser Asn Ile Gly Asn Asn Ala 
1               5               


<210>  1687
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-2E9

<400>  1687

Tyr Asp Asp 
1           


<210>  1688
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-2E9

<400>  1688

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  1689
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-2G8

<400>  1689

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Leu Tyr Ser Gly Gly Thr Thr Phe Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Trp Ser Gly Thr Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  1690
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-2G8

<400>  1690

Gly Ile Thr Val Ser Ser Asn Tyr 
1               5               


<210>  1691
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-2G8

<400>  1691

Leu Tyr Ser Gly Gly Thr Thr 
1               5           


<210>  1692
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-2G8

<400>  1692

Ala Arg Trp Ser Gly Thr Tyr Tyr Asp Tyr 
1               5                   10  


<210>  1693
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-2G8

<400>  1693

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Thr Asn Asp Pro 
                85                  90                  95      


Val Leu Phe Gly Ala Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  1694
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-2G8

<400>  1694

Ser Leu Arg Ser Tyr Tyr 
1               5       


<210>  1695
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-2G8

<400>  1695

Gly Lys Asn 
1           


<210>  1696
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-2G8

<400>  1696

Asn Ser Arg Asp Ser Thr Asn Asp Pro Val Leu 
1               5                   10      


<210>  1697
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-6B10

<400>  1697

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Arg Tyr Gly Asp Ser Gly Ser Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  1698
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-6B10

<400>  1698

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  1699
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-6B10

<400>  1699

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  1700
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-6B10

<400>  1700

Ala Arg Asp Arg Leu Arg Tyr Gly Asp Ser Gly Ser Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  1701
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-6B10

<400>  1701

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Ser Glu Val Thr Arg Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  1702
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-6B10

<400>  1702

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  1703
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-6B10

<400>  1703

Glu Val Thr 
1           


<210>  1704
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-6B10

<400>  1704

Gly Ser Tyr Ala Gly Ser Asn Thr Trp Val 
1               5                   10  


<210>  1705
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-6C1

<400>  1705

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Val Gly Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  1706
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-6C1

<400>  1706

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1707
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-6C1

<400>  1707

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  1708
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-6C1

<400>  1708

Ala Arg Ser Tyr Val Gly Gly Met Asp Val 
1               5                   10  


<210>  1709
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-6C1

<400>  1709

Gln Leu Val Leu Thr Gln Ser Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asp Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Ser Tyr Thr Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Arg Thr 
                85                  90                  95      


Leu Val Gly Ser Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  1710
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-6C1

<400>  1710

Asp Ser Asn Ile Gly Ala Gly Tyr Asn 
1               5                   


<210>  1711
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-6C1

<400>  1711

Tyr Thr Asp 
1           


<210>  1712
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-6C1

<400>  1712

Gln Ser Ser Asp Arg Thr Leu Val Gly Ser Leu 
1               5                   10      


<210>  1713
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-6C8

<400>  1713

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ile Ala Ala Leu Asn Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  1714
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-6C8

<400>  1714

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1715
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-6C8

<400>  1715

Ile Ile Pro Ile Leu Gly Ile Ala 
1               5               


<210>  1716
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-6C8

<400>  1716

Ala Arg Ser Ile Ala Ala Leu Asn Trp Phe Asp Pro 
1               5                   10          


<210>  1717
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-6C8

<400>  1717

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Pro Cys Thr Gly Ser Arg Gly Ser Ile Ala Asn Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Arg Gln Arg Pro Gly Arg Ala Pro Thr Thr Val 
        35                  40                  45              


Ile Phe Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Glu Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                85                  90                  95      


Ser Asn Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  1718
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-6C8

<400>  1718

Arg Gly Ser Ile Ala Asn Asn Tyr 
1               5               


<210>  1719
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-6C8

<400>  1719

Glu Asp Asn 
1           


<210>  1720
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-6C8

<400>  1720

Gln Ser Tyr Asp Gly Ser Asn Val Ile 
1               5                   


<210>  1721
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH STE73-9G3

<400>  1721

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Val Leu Gly Ser Gly Ser Ser Asn Asp Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1722
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH STE73-9G3

<400>  1722

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  1723
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH STE73-9G3

<400>  1723

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  1724
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH STE73-9G3

<400>  1724

Ala Arg Asp Leu Val Leu Gly Ser Gly Ser Ser Asn Asp 
1               5                   10              


<210>  1725
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL STE73-9G3

<400>  1725

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asp Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Ser Tyr Thr Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Arg Thr 
                85                  90                  95      


Leu Val Gly Ser Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  1726
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL STE73-9G3

<400>  1726

Asp Ser Asn Ile Gly Ala Gly Tyr Asn 
1               5                   


<210>  1727
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL STE73-9G3

<400>  1727

Tyr Thr Asp 
1           


<210>  1728
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL STE73-9G3

<400>  1728

Gln Ser Ser Asp Arg Thr Leu Val Gly Ser Leu 
1               5                   10      


<210>  1729
<211>  669
<212>  DNA
<213>  artificial sequence

<220>
<223>  SARS-CoV-2 RBD 7PM Mutant

<400>  1729
cgggtgcagc ccaccgaatc catcgtgcgg ttccccaata tcaccaatct gtgccccttc       60

ggcgaggtgt tcaatgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc      120

agcaattgcg tggccgacta ctccttcctg tacaactccg ccagcttcag caccttcaag      180

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcacaaacgt gtacgccgac      240

agcttcgtga tccggggaga tgaagtgcgg cagattgccc ctggacagac aggcaagatc      300

gccgactaca actacaagct gcccgacgac ttcaccggct gtgtgattgc ctggaacagc      360

aagaacctgg actccaaagt cggcggcaac tacaattacc tgtaccggct gttccggaag      420

tccaatctga agcccttcga gcgggacatc tccaccgaga tctatcaggc cagcagcacc      480

ccttgtaacg gcgcgaaacg cgtcaactgc tacttcccac tgcagtccta cggctttcag      540

cccacaaatg gcgtgggcta ccagccttac agagtggtgg tgctgagctt cgagctgctg      600

catgctcctg ccacagtgtg cggccctaag aaaagcacca atctcgtgaa gaacaaatgc      660

gtgaacttc                                                              669


<210>  1730
<211>  223
<212>  PRT
<213>  artificial sequence

<220>
<223>  SARS-CoV-2 RBD 7PM Mutant

<400>  1730

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Phe Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Lys Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Ser Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Ala Lys Arg Val Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  1731
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 HCDR1 DNA

<400>  1731
gactactaca tgagc                                                        15



<210>  1732
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 HCDR1 PRT

<400>  1732
Asp Tyr Tyr Met Ser 
1               5   


<210>  1733
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 HCDR2 DNA

<400>  1733
tacattactt atagtggtag taccatatac tacgcagact ctgtgaaggg c                51



<210>  1734
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 HCDR2 PRT

<400>  1734
Tyr Ile Thr Tyr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  1735
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 HCDR3 DNA

<400>  1735
gatcgcggta caactatggt cccctttgac tac                                    33



<210>  1736
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 HCDR3 PRT

<400>  1736
Asp Arg Gly Thr Thr Met Val Pro Phe Asp Tyr 
1               5                   10      


<210>  1737
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 LCDR1 DNA

<400>  1737
caggcgagtc aggacattac caactattta aat                                    33



<210>  1738
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 LCDR1 PRT

<400>  1738
Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  1739
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 LCDR2 DNA

<400>  1739
gctgcatcca atttggaaac a                                                 21



<210>  1740
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 LCDR2 PRT

<400>  1740
Ala Ala Ser Asn Leu Glu Thr 
1               5           


<210>  1741
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 LCDR3 DNA

<400>  1741
caacagtatg ataatctccc tctcact                                           27



<210>  1742
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 LCDR3 PRT

<400>  1742
Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  1743
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 VL DNA

<400>  1743
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattacc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgct gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcgg cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321



<210>  1744
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 VL PRT

<400>  1744
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  1745
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 VH DNA

<400>  1745
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attacttata gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagag ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagatcgc      300

ggtacaacta tggtcccctt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  1746
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 VH PRT

<400>  1746
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Tyr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Thr Thr Met Val Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1747
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 VH complete DNA

<400>  1747
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attacttata gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagag ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagatcgc      300

ggtacaacta tggtcccctt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  1748
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 VH complete PRT

<400>  1748
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Tyr Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Thr Thr Met Val Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  1749
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10933 VL complete DNA

<400>  1749
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattacc aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacgct gcatccaatt tggaaacagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcgg cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tatgataatc tccctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtgttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642



<210>  1750
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10933 VL complete PRT

<400>  1750
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  1751
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 HCDR1 DNA

<400>  1751
aactatgcta tgtac                                                        15



<210>  1752
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 HCDR1 PRT

<400>  1752
Asn Tyr Ala Met Tyr 
1               5   


<210>  1753
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 HCDR2 DNA

<400>  1753
gttatatcat atgatggaag taataaatac tatgcagact ccgtgaaggg c                51



<210>  1754
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 HCDR2 PRT

<400>  1754
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      



<210>  1755
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 HCDR3 DNA

<400>  1755
ggctccgact acggtgacta cttattggtt tac                                    33



<210>  1756
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 HCDR3 PRT

<400>  1756
Gly Ser Asp Tyr Gly Asp Tyr Leu Leu Val Tyr 
1               5                   10      


<210>  1757
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 LCDR1 DNA

<400>  1757
actggaacca gcagtgacgt tggtggttat aactatgtct cc                          42



<210>  1758
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 LCDR1 PRT

<400>  1758
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  1759
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 LCDR2 DNA

<400>  1759
gatgtcagta agcggccctc a                                                 21



<210>  1760
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 LCDR2 PRT

<400>  1760
Asp Val Ser Lys Arg Pro Ser 
1               5           


<210>  1761
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 LCDR3 DNA

<400>  1761
aactctttga caagcatcag cacttgggtg                                        30



<210>  1762
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 LCDR3 PRT

<400>  1762
Asn Ser Leu Thr Ser Ile Ser Thr Trp Val 
1               5                   10  


<210>  1763
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 VL DNA

<400>  1763
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgc aactctttga caagcatcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330



<210>  1764
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 VL PRT

<400>  1764
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Thr Ser Ile 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  1765
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 VH DNA

<400>  1765
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatgcta tgtactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag aactgaggac acggctgtgt attactgtgc gagtggctcc      300

gactacggtg actacttatt ggtttactgg ggccagggaa ccctggtcac cgtgtcctca      360

                                                                       360



<210>  1766
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 VH PRT

<400>  1766
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Ser Asp Tyr Gly Asp Tyr Leu Leu Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  1767
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 VH complete DNA

<400>  1767
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatgcta tgtactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag aactgaggac acggctgtgt attactgtgc gagtggctcc      300

gactacggtg actacttatt ggtttactgg ggccagggaa ccctggtcac cgtgtcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctccagt ggccggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtggg cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaacagctc ccatccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aaaagcctct ccctgtcccc gggt                                            1344



<210>  1768
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 VH complete PRT

<400>  1768
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Ser Asp Tyr Gly Asp Tyr Leu Leu Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  1769
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  REGN10987 VL complete DNA

<400>  1769
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacaa      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgc aactctttga caagcatcag cacttgggtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcacc aagtgtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648



<210>  1770
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  REGN10987 VL complete PRT

<400>  1770
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Thr Ser Ile 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  1771
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 HCDR1 DNA

<400>  1771
agtaattata tgtca                                                        15



<210>  1772
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 HCDR1 PRT

<400>  1772
Ser Asn Tyr Met Ser 
1               5   


<210>  1773
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 HCDR2 DNA

<400>  1773
gtgatctaca gcggtgggag cacattttat gcggatagtg ttaagggt                    48



<210>  1774
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 HCDR2 PRT

<400>  1774
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  1775
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 HCDR3 DNA

<400>  1775
gttcttccaa tgtatggcga ttacttggat tat                                    33



<210>  1776
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 HCDR3 PRT

<400>  1776
Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr 
1               5                   10      


<210>  1777
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 LCDR1 DNA

<400>  1777
cgcgcatccc aaagcatctc tcggtatctt aat                                    33



<210>  1778
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 LCDR1 PRT

<400>  1778
Arg Ala Ser Gln Ser Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  1779
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 LCDR2 DNA

<400>  1779
gcagctagtt cacttcagtc a                                                 21



<210>  1780
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 LCDR2 PRT

<400>  1780
Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  1781
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 LCDR3 DNA

<400>  1781
caacagtcat atagcacacc gcccgagtac act                                    33



<210>  1782
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 LCDR3 PRT

<400>  1782
Gln Gln Ser Tyr Ser Thr Pro Pro Glu Tyr Thr 
1               5                   10      


<210>  1783
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 VL DNA

<400>  1783
gatatagtaa tgacacagtc cccctccagt cttagtgcct ccgtgggcga ccgagttacg       60

attacctgcc gcgcatccca aagcatctct cggtatctta attggtacca acaaaagcct      120

ggaaaggcgc ccaaattgtt gatatacgca gctagttcac ttcagtcagg ggtgccgagt      180

cggttcagcg ggtccggtag cggcaccgat ttcacactca caatttctag cctgcaaccc      240

gaagactttg ctacctatta ctgtcaacag tcatatagca caccgcccga gtacactttc      300

gggcagggga ccaagctgga gatcaaa                                          327



<210>  1784
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 VL PRT

<400>  1784
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  1785
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 VH DNA

<400>  1785
gaagttcagt tggtggagtc agggggaggt cttgtccagc caggtggctc cctgagattg       60

agttgcgctg cttctggatt cactgtgagc agtaattata tgtcatgggt gcgccaggcg      120

cctgggaagg ggcttgagtg ggtgtccgtg atctacagcg gtgggagcac attttatgcg      180

gatagtgtta agggtaggtt tacgatatct cgagataatt ccatgaacac attgttcttg      240

caaatgaaca gccttcgggc tgaagacact gccgtctatt actgtgctag agttcttcca      300

atgtatggcg attacttgga ttattggggg caagggacac tcgtgactgt ttcctca         357



<210>  1786
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 VH PRT

<400>  1786
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  1787
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 VH complete DNA

<400>  1787
gaagttcagt tggtggagtc agggggaggt cttgtccagc caggtggctc cctgagattg       60

agttgcgctg cttctggatt cactgtgagc agtaattata tgtcatgggt gcgccaggcg      120

cctgggaagg ggcttgagtg ggtgtccgtg atctacagcg gtgggagcac attttatgcg      180

gatagtgtta agggtaggtt tacgatatct cgagataatt ccatgaacac attgttcttg      240

caaatgaaca gccttcgggc tgaagacact gccgtctatt actgtgctag agttcttcca      300

atgtatggcg attacttgga ttattggggg caagggacac tcgtgactgt ttcctcagct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctccagtggc cggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtgggcgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa acagctccca tcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaaa     1320

agcctctccc tgtccccggg t                                               1341



<210>  1788
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 VH complete PRT

<400>  1788
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Leu Pro Met Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  1789
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB6 VL complete DNA

<400>  1789
gatatagtaa tgacacagtc cccctccagt cttagtgcct ccgtgggcga ccgagttacg       60

attacctgcc gcgcatccca aagcatctct cggtatctta attggtacca acaaaagcct      120

ggaaaggcgc ccaaattgtt gatatacgca gctagttcac ttcagtcagg ggtgccgagt      180

cggttcagcg ggtccggtag cggcaccgat ttcacactca caatttctag cctgcaaccc      240

gaagactttg ctacctatta ctgtcaacag tcatatagca caccgcccga gtacactttc      300

gggcagggga ccaagctgga gatcaaacgt acggtggctg caccatctgt gttcatcttc      360

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      420

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      480

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      540

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      600

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                   648



<210>  1790
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CB6 VL complete PRT

<400>  1790
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Glu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  1791
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 HCDR1 DNA

<400>  1791
acgtactgga ttggc                                                        15



<210>  1792
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 HCDR1 PRT

<400>  1792
Thr Tyr Trp Ile Gly 
1               5   


<210>  1793
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 HCDR2 DNA

<400>  1793
ataatttacc ctggcgattc agagactcgg tattctccat cctttcaggg c                51



<210>  1794
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 HCDR2 PRT

<400>  1794
Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      



<210>  1795
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 HCDR3 DNA

<400>  1795
ggatcaggaa tcagcacgcc catggacgta                                        30



<210>  1796
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 HCDR3 PRT

<400>  1796
Gly Ser Gly Ile Ser Thr Pro Met Asp Val 
1               5                   10  


<210>  1797
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 LCDR1 DNA

<400>  1797
aaatctagcc agtctgttct gtactcatct ataaataaga actatcttgc g                51



<210>  1798
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 LCDR1 PRT

<400>  1798
Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Ile Asn Lys Asn Tyr Leu 
1               5                   10                  15      



<210>  1799
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 LCDR2 DNA

<400>  1799
tgggcttcca cgagagaaag c                                                 21



<210>  1800
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 LCDR2 PRT

<400>  1800
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  1801
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 LCDR3 DNA

<400>  1801
cagcaatact attccacacc ctacaca                                           27



<210>  1802
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 LCDR3 PRT

<400>  1802
Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  1803
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 VL DNA

<400>  1803
gatattcagc tcacccagtc tccagactct ctggcggtct cactcggtga gagagcgaca       60

ataaactgta aatctagcca gtctgttctg tactcatcta taaataagaa ctatcttgcg      120

tggtaccagc agaaaccagg tcagcctcct aagctcttga tttactgggc ttccacgaga      180

gaaagcggcg tgcccgaccg gttcagcggc tcagggagcg gcactgattt cactctgacg      240

atcagcagtc tgcaggccga ggatgtagcc gtatattatt gtcagcaata ctattccaca      300

ccctacacat tcgggcaggg aactaaagtt gagataaag                             339



<210>  1804
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 VL PRT

<400>  1804
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         
    


<210>  1805
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 VH DNA

<400>  1805
caaatgcagt tggtacagag tggtaccgag gtcaaaaaac ctggcgagag tctcaaaatc       60

tcatgcaaag ggtccggcta tggattcatt acgtactgga ttggctgggt taggcagatg      120

ccggggaaag ggcttgagtg gatgggaata atttaccctg gcgattcaga gactcggtat      180

tctccatcct ttcagggcca agtcacaatt tcagcagata agtccatcaa caccgcgtac      240

ctccagtggt ctagtttgaa agcaagcgac acagccatat attattgcgc cggtggatca      300

ggaatcagca cgcccatgga cgtatgggga cagggcacta cagtcacagt ttcaagt         357



<210>  1806
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 VH PRT

<400>  1806
Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  1807
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 VH complete DNA

<400>  1807
caaatgcagt tggtacagag tggtaccgag gtcaaaaaac ctggcgagag tctcaaaatc       60

tcatgcaaag ggtccggcta tggattcatt acgtactgga ttggctgggt taggcagatg      120

ccggggaaag ggcttgagtg gatgggaata atttaccctg gcgattcaga gactcggtat      180

tctccatcct ttcagggcca agtcacaatt tcagcagata agtccatcaa caccgcgtac      240

ctccagtggt ctagtttgaa agcaagcgac acagccatat attattgcgc cggtggatca      300

ggaatcagca cgcccatgga cgtatgggga cagggcacta cagtcacagt ttcaagtgct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctccagtggc cggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtgggcgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgggtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa acagctccca tcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaaa     1320

agcctctccc tgtccccggg t                                               1341



<210>  1808
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 VH complete PRT

<400>  1808
Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Gly Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ser Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  1809
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CR3022 VL complete DNA

<400>  1809
gatattcagc tcacccagtc tccagactct ctggcggtct cactcggtga gagagcgaca       60

ataaactgta aatctagcca gtctgttctg tactcatcta taaataagaa ctatcttgcg      120

tggtaccagc agaaaccagg tcagcctcct aagctcttga tttactgggc ttccacgaga      180

gaaagcggcg tgcccgaccg gttcagcggc tcagggagcg gcactgattt cactctgacg      240

atcagcagtc tgcaggccga ggatgtagcc gtatattatt gtcagcaata ctattccaca      300

ccctacacat tcgggcaggg aactaaagtt gagataaagc gtacggtggc tgcaccatct      360

gtgttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

                                                                    
<210>  1810
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 VL complete PRT

<400>  1810
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220

<210>  1811
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 437 to 463)

<400>  1811
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu
1               5                   10                  15     

Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro
            20                  25         

<210>  1812
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 445 to 451)

<400>  1812
Val Gly Gly Asn Tyr Asn Tyr
1               5          

<210>  1813
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 445 to 455)

<400>  1813
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu
1               5                   10     

<210>  1814
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 445 to 459)

<400>  1814
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser
1               5                   10                  15 

<210>  1815
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 449 to 459)

<400>  1815
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser
1               5                   10

<210>  1816
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 342 to 351)

<400>  1816
Val Phe Asn Thr Arg Phe Ala Ser Val Tyr
1               5                   10 

<210>  1817
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 349 to 359)

<400>  1817
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser
1               5                   10     

<210>  1818
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 485 to 491) 

<400>  1818
Gly Phe Asn Cys Tyr Phe Pro
1               5          

<210>  1819
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 497 to 502)

<400>  1819
Phe Gln Pro Thr Asn Val
1               5      

<210>  1820
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 400 to 422)

<400>  1820
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gln Thr Gly
1               5                   10                  15     

Lys Ile Ala Asp Asp Tyr Asn
            20

<210>  1821
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 165 to 180)  

<400>  1821
Ala Lys Arg Val Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln
1               5                   10                  15     

<210>  1822
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 365 to 369)  

<400>  1822
Tyr Ser Phe Leu Tyr
1               5

<210>  1823
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 436 to 443)  

<400>  1823
Trp Asn Ser Lys Asn Leu Asp
1               5          


<210>  1824
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 474 to 489)  

<400>  1824
Gln Ala Ser Ser Thr Pro Cys Asn Gly Ala Lys Arg Val Asn Cys Tyr
1               5                   10                  15     

<210>  1825
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 483 to 490)  

<400>  1825
Val Glu Gly Phe Asn Cys Tyr Phe
1               5              

<210>  1826
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 400 to 422)  

<400>  1826
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gln Thr Gly
1               5                   10                  15     

Lys Ile Ala Asp Tyr Asn
            20       

<210>  1827
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 470 to 480)  

<400>  1827
Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys
1               5                   10     

<210>  1828
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope within RBD (amino acids 483 to 505)  

<400>  1828
Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln
1               5                   10                  15     

Pro Thr Asn Gly Val
            20     

<210>  1829
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  partial S1-Domain (7PM)  

<400>  1829
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn
1               5                   10                  15     
 
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val
            20                  25                  30         

Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser
        35                  40                  45             

Phe Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val
    50                  55                  60                 

Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp
65                  70                  75                  80 

Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln
                85                  90                  95     

Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr
            100                 105                 110        

Gly Cys Val Ile Ala Trp Asn Ser Lys Asn Leu Asp Ser Lys Val Gly
        115                 120                 125            

Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys
    130                 135                 140                

Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Ser Ser Thr
145                 150                 155                 160

Pro Cys Asn Gly Ala Lys Arg Val Asn Cys Tyr Phe Pro Leu Gln Ser
                165                 170                 175    

Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val
            180                 185                 190        

Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly
        195                 200                 205            

Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn
    210                 215                 220                

<210>  1830
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  partial S1-Domain (wild-type)    

<400>  1830
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn
1               5                   10                  15     

Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val
            20                  25                  30         

Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser
        35                  40                  45             

Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val
    50                  55                  60                 

Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp
65                  70                  75                  80 

Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln
                85                  90                  95     

Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr
            100                 105                 110        

Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly
        115                 120                 125            

Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys
    130                 135                 140                

Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr
145                 150                 155                 160

Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser
                165                 170                 175    

Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val
            180                 185                 190        

Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly
        195                 200                 205            

Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn
    210                 215                 220

<210>  1831
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "archetype" light chain CDR1

<400>  1831

Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10

<210>  1832
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "archetype" light chain CDR2

<400>  1832

Ala Ala Ser Thr Leu Gln Ser 
1               5

<210>  1833
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "archetype" light chain CDR3

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is proline or can be deleted

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is phenylalanine or isoleucine

<400>  1833

Gln Gln Leu Asn Ser Tyr Pro Xaa Xaa Thr  
1               5                   10

<210>  1834
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "archetype" heavy chain CDR1

<400>  1834

Ser Asn Tyr Met Ser
1               5

<210>  1835
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "archetype" heavy chain CDR2

<400>  1835

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15

<210>  1836
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "archetype" heavy chain CDR3

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is valine or leucine

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is alanine or valine

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is alanine or glycine

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is phenylalanine or leucine

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is isoleucine or valine

<400>  1836

Asp Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa  
1               5      

<210>  1837
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" light chain CDR1

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is alanine or glycine

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is glycine or serine

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is serine or glycine

<220>
<221>  VARIANT
<222>  (6)..(7)
<223>  Xaa can be deleted or any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is asparagine or serine

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is asparagine or serine

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is leucine or valine

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is alanine or serine

<400>  1837

Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa 
1               5                   10

<210>  1838
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" light chain CDR1

<220>
<221>  VARIANT
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (4)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  1838

Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa 
1               5                   10

<210>  1839
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" light chain CDR2

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is threonine or alanine

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is asparagine or serine

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is lysine or threonine

<220>
<221>  VARIANT
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  1839

Xaa Xaa Xaa Xaa Xaa Xaa Ser
1               5

<210>  1840
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" light chain CDR2

<220>
<221>  VARIANT
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  1840

Xaa Xaa Xaa Xaa Xaa Xaa Ser
1               5

<210>  1841
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" light chain CDR3

<220>
<221>  VARIANT
<222>  (1)..(3)
<223>  Xaa can be deleted or any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is asparagine or aspartic acid

<220>
<221>  VARIANT
<222>  (4)..(10)
<223>  Xaa can be deleted or any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is valine or threonine

<400>  1841

Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa
1               5                   10

<210>  1842
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" light chain CDR3

<220>
<221>  VARIANT
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (8)..(9)
<223>  Xaa can be deleted or any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  1842

Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa
1               5                   10

<210>  1843
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" heavy chain CDR3

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is glycine or aspartic acid

<220>
<221>  VARIANT
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (4)..(6)
<223>  Xaa can be deleted or any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is alanine or glycine

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is methionine, phenylalanine or leucine

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is isoleucine or valine

<400>  1843

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa
1               5                   10

<210>  1844
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "generalized" heavy chain CDR3

<220>
<221>  VARIANT
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (4)..(6)
<223>  Xaa can be deleted or any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  1844

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa
1               5                   10
                