               SEQUENCE LISTING

<110> Chr Hansen A/S

<120> METHOD OF INCREASING NISIN PRODUCTION IN LACTOCOCCUS LACTIS

<130> P6965PC00

<160> 13

<170> BiSSAP 1.3.6

<210> 1
<211> 892
<212> PRT
<213> Lactococcus lactis


<400> 1
Leu Phe Ala Leu Asp Trp Lys Arg Ile Phe Lys Asn Pro Val Ala Thr 
1               5                   10                  15      
Phe Leu Ile Val Ala Leu Met Ile Ile Pro Ser Leu Tyr Ala Trp Phe 
            20                  25                  30          
Asn Ile Lys Ala Leu Trp Asp Pro Tyr Ala Asn Thr Ser Gln Leu Pro 
        35                  40                  45              
Ile Ala Val Tyr Ser Ala Asp Lys Pro Ala Ser Phe Gln Asp Lys Thr 
    50                  55                  60                  
Ile Asn Ile Gly Asp Glu Val Leu Lys Asn Leu Lys Lys Asn His Gln 
65                  70                  75                  80  
Leu Gly Trp Lys Phe Val Asp Ser Lys Ala Glu Leu Asp Lys Gly Val 
                85                  90                  95      
Lys Ser Gly Lys Tyr Tyr Ala Gly Ile Tyr Leu Pro Lys Asp Phe Ser 
            100                 105                 110         
Lys Asp Leu Leu Ser Phe Thr Thr Gly Asp Ile Lys Lys Pro Gln Ile 
        115                 120                 125             
Val Tyr Ser Ile Asn Glu Lys Ile Asn Ala Ile Ala Pro Lys Ile Thr 
    130                 135                 140                 
Ser Lys Gly Ala Ser Ser Leu Gln Ser Gln Ile Ser Glu Glu Phe Ile 
145                 150                 155                 160 
Asn Thr Ala Ser Ser Thr Leu Leu Lys Thr Phe Asn Thr Ile Gly Tyr 
                165                 170                 175     
Asp Ile Asp Lys Asn Met Val Ser Ile Gln Lys Val Lys Ser Ala Ile 
            180                 185                 190         
Leu Ser Thr Asn Asp Asn Leu Gly Thr Ile Asp Lys Tyr Thr Gln Gln 
        195                 200                 205             
Val Val Asp Leu His Gly Lys Met Pro Glu Ile Lys Glu Lys Leu Ala 
    210                 215                 220                 
Lys Ala Asn Glu Phe Ile Thr Tyr Leu Pro Glu Val Asp Ser Leu Gly 
225                 230                 235                 240 
Gln Lys Val Ile Ser Leu Asn Asp Lys Met Pro Glu Ile Asp Lys Ser 
                245                 250                 255     
Leu Ser Leu Val Leu Thr Leu Gln Glu Lys Ile Pro Glu Ile Gln Asn 
            260                 265                 270         
Ala Gly Lys Gln Ile Ser Met Ile Asp Glu Asp Phe Ala Ser Val Glu 
        275                 280                 285             
Ser Thr Met Thr Gln Gly Ile Gln Glu Ala Lys Asp Gly Leu Gln Ile 
    290                 295                 300                 
Ile Asn Gln Val Gln Lys Ser Met Pro Asp Ile Gln Lys Leu Gly Gln 
305                 310                 315                 320 
Asp Ala Asp Ser Leu Gly Thr Val Thr Leu Asp Ala Ala Lys Lys Met 
                325                 330                 335     
Gln Ser Ala Leu Pro Ser Ile Thr Asn Ser Val Gln Ile Thr Leu Gln 
            340                 345                 350         
Ser Ile Gln Glu Phe Ser Lys Asn Thr Ser Ser Val Leu Ala Val Ile 
        355                 360                 365             
Asp Gln Ala Ile Ala Asp Asn Gln Leu Thr Asp Glu Glu Lys Glu Gln 
    370                 375                 380                 
Ile Asn Ser Leu Ile Thr Asn Phe Ile Asn Asn Ile Ala Arg Gln Arg 
385                 390                 395                 400 
Glu Ala Ile Gln Asn Ile Val Asp Tyr Met Lys Gln Val Gln Glu Ser 
                405                 410                 415     
Asn Gly Ser His Asp Leu Asp Ser Thr Ile Glu Gln Leu Ser Asn Leu 
            420                 425                 430         
Asp Ser Leu Leu Ser Gly Leu Ser Thr Arg Met Asn His Leu Asn Glu 
        435                 440                 445             
Leu Val Gln Asn Gly Asp Val Ser Glu Ile Arg Ala Tyr Leu Ser Gln 
    450                 455                 460                 
Ile Asn Asp Val Val Thr Lys Ile Ser Asn Leu Val Asp Asn Ile Asp 
465                 470                 475                 480 
Val Ser Gly Ile Ser Lys Thr Ile Asp Thr Val Leu Thr Ser Leu Thr 
                485                 490                 495     
Lys Thr Ile Ala Asp Ala Lys Gly Leu Leu Asn Gln Ala Gln Gln Ile 
            500                 505                 510         
Asp Phe Glu Ala Leu Leu Asn Ser Thr Ser Gln Thr Val Ser Asn Ala 
        515                 520                 525             
Val Thr Ile Leu Glu Lys Tyr Gln Gly Glu Met Pro Ala Ile Lys Gln 
    530                 535                 540                 
Glu Ile His Asp Ala Asn Leu Met Leu Asn Gly Asn Met Thr Thr Ile 
545                 550                 555                 560 
Val Asn Ala Ile Asn Glu Gly Ala Ser Leu Tyr Lys Asn Glu Phe Pro 
                565                 570                 575     
Ile Leu Lys Thr Lys Leu Gly Thr Ala Ser Asp Phe Phe Lys Asn Asp 
            580                 585                 590         
Tyr Ala Gly Val Arg Lys Asp Leu Thr Asp Thr Leu Thr Met Ala Asn 
        595                 600                 605             
Glu Lys Met Pro Asp Val Glu Ser Ala Leu Asn Gln Ala Asn Ser Leu 
    610                 615                 620                 
Ile Gln Asn Asp Trp Pro Glu Ile Lys Ser Gly Ile Gln Lys Ala Ala 
625                 630                 635                 640 
Thr Ala Ile Gln Lys Gly Glu Lys Glu Val Asp Leu Gly Glu Ile Val 
                645                 650                 655     
Lys Leu Leu Lys Leu Asp Ala Thr Lys Glu Ser Asp Phe Trp Thr Gln 
            660                 665                 670         
Pro Val Glu Val Gln Glu Asn Gln Val Tyr Pro Ile Ala Asn Asn Gly 
        675                 680                 685             
Ser Ala Ser Thr Pro Phe Tyr Thr Ala Leu Cys Leu Trp Val Gly Ala 
    690                 695                 700                 
Val Leu Leu Ser Ser Leu Ala Thr Thr Glu Val His Leu Ser Asp Lys 
705                 710                 715                 720 
Asp Lys Lys Arg Tyr Ser Lys Arg Glu Gln Phe Phe Ala Arg Met Gly 
                725                 730                 735     
Ser Phe Val Ala Ile Gly Leu Ala Gln Ala Leu Ile Val Thr Leu Gly 
            740                 745                 750         
Asn Tyr Phe Gly Leu Gly Val Asp Val Arg Asp Pro Phe Tyr Ser Val 
        755                 760                 765             
Leu Phe Ala Leu Leu Ile Ser Ile Ala Phe Met Ile Met Val Tyr Val 
    770                 775                 780                 
Leu Val Ala Leu Phe Gly Asn Val Gly Lys Gly Ile Ala Ile Ile Ile 
785                 790                 795                 800 
Leu Val Leu Ser Ile Ser Gly Gly Gly Gly Asn Tyr Pro Ile Gln Val 
                805                 810                 815     
Ser Gly Lys Phe Phe Gln Ala Ile Asn Pro Tyr Leu Pro Phe Thr His 
            820                 825                 830         
Ala Val Asn Leu Leu Arg Glu Ser Ala Gly Gly Ile Tyr Trp Pro Asn 
        835                 840                 845             
Ala Trp Phe Ala Ile Ile Ile Leu Val Ala Val Ser Ile Ile Phe Val 
    850                 855                 860                 
Ala Ile Gly Ala Ile Leu Phe Pro His Phe Glu Asp Lys Thr Lys Lys 
865                 870                 875                 880 
Ile Ser Glu Ile Gly Ser Lys Ser His Phe Phe His 
                885                 890         

<210> 2
<211> 2679
<212> DNA
<213> Lactococcus lactis


<400> 2
ttgtttgccc tagactggaa acgaattttt aaaaatcctg tggcgacctt tttaatcgtt      60

gccttaatga taattccctc tttatatgct tggtttaaca ttaaagcctt gtgggaccct     120

tatgccaata cctcgcaatt gccaattgca gtctacagtg cagataaacc tgctagtttt     180

caagataaaa ccataaacat tggtgatgaa gttctgaaga atttaaagaa aaatcatcaa     240

ttaggttgga aatttgtaga ttctaaagca gaattagata aaggagttaa atccggaaaa     300

tactatgctg gaatttactt accaaaggat ttttcaaaag accttttaag ttttacaacc     360

ggtgatatta aaaagccaca aatagtttat tctattaatg aaaagataaa tgctattgct     420

cccaaaataa cctctaaggg tgcttcatct cttcaatcac agatttctga agagtttatt     480

aatacggcaa gtagtacact cttaaaaacc tttaatacga ttggttacga tattgataaa     540

aatatggtca gcattcaaaa ggttaagtca gcaattttat caacaaacga taatctagga     600

accattgaca aatacaccca acaagtggtt gaccttcatg gtaaaatgcc agaaatcaaa     660

gaaaaactgg ctaaggctaa cgaatttatt acttatttac ccgaagttga ttctttaggt     720

caaaaagtaa ttagtttgaa tgataaaatg cctgaaattg ataaaagttt gtcacttgtt     780

ttgactcttc aagaaaaaat tcctgaaatt caaaacgctg gtaaacaaat ttcgatgatt     840

gatgaagact ttgcgtcagt tgaaagtact atgacccaag gaattcaaga agcaaaagac     900

ggcttgcaaa tcatcaatca agtccaaaaa tcaatgccag acattcaaaa attaggacaa     960

gatgcagata gtttagggac tgtgacattg gatgcagcga aaaaaatgca gagcgcattg    1020

cctagtatca cgaatagcgt tcaaatcact ctacagtcta ttcaagaatt ttcaaaaaat    1080

acttcctcag ttctcgctgt tattgaccaa gcaatagctg ataatcagct cacagatgaa    1140

gaaaaagaac aaataaatag tttaattacc aactttatta acaatatcgc ccgacaaaga    1200

gaagcaattc aaaatattgt tgattacatg aaacaagtcc aagagagcaa tggaagtcat    1260

gatttagact caacaattga gcaactcagt aatcttgatt ctttactgtc aggacttagt    1320

actagaatga atcatctgaa tgagttagta caaaatggtg atgtatctga aattcgtgct    1380

tacttatccc aaattaatga tgtggttact aaaatctcta atttagttga taatattgat    1440

gtgagtggaa ttagtaaaac aattgataca gttttaacaa gcttgactaa aacaatcgct    1500

gatgccaaag gtttattaaa tcaagctcaa caaattgact ttgaagcttt actaaattca    1560

acaagtcaaa cagtttctaa tgctgttacc attttagaaa aatatcaagg tgaaatgcca    1620

gccatcaaac aagaaattca tgatgcaaac ttgatgttaa atggaaatat gacgacaatt    1680

gtcaatgcaa ttaacgaagg ggctagtctt tataaaaatg agttccctat ccttaaaact    1740

aagttgggca cagcttctga tttctttaaa aatgattatg ctggtgttcg taaagattta    1800

acagatacct taacaatggc aaatgagaaa atgcctgacg tcgagtctgc tttgaatcaa    1860

gccaatagtt taatccaaaa tgactggcct gaaatcaaat cgggcattca aaaagcagca    1920

acagccattc aaaaaggtga aaaagaagtt gatttaggag agattgttaa acttctaaaa    1980

cttgatgcta ctaaagagag tgacttttgg acccaaccag tagaagtgca agaaaatcaa    2040

gtttatccta ttgccaacaa tggttcggca agtacacctt tctacacagc gctttgtctg    2100

tgggtcggtg cagtcttact ttcaagtttg gcaacaacag aggttcatct atcagataaa    2160

gataaaaaac gttattctaa acgtgaacaa ttctttgctc gaatgggaag tttcgtagcc    2220

attggacttg ctcaagcctt gattgtaacc ttaggaaact actttggttt aggggtagat    2280

gtacgagacc cattctacag cgtcctcttt gccttactga tatccatcgc ctttatgata    2340

atggtttatg ttctagtcgc gctatttggt aatgttggta aaggaatagc gattattatc    2400

cttgtacttt ccatttctgg tggtggtggg aactatccaa tccaagtttc tggaaaattc    2460

ttccaagcca ttaatcctta tttaccattt acccacgctg ttaatctttt acgagaatcg    2520

gctggaggga tttattggcc aaacgcttgg tttgcaataa ttatccttgt ggcagtatca    2580

attatatttg ttgcaattgg ggccattctc ttcccacact ttgaagataa aacgaagaaa    2640

atttctgaaa tcggaagtaa gagtcatttc ttccattaa                           2679


<210> 3
<211> 901
<212> PRT
<213> Lactococcus lactis


<400> 3
Val Lys Ser Ile Lys Asn Thr Trp Lys Leu Phe Ala Leu Asp Trp Lys 
1               5                   10                  15      
Arg Ile Phe Lys Asn Pro Val Ala Thr Phe Leu Ile Val Ala Leu Met 
            20                  25                  30          
Ile Ile Pro Ser Leu Tyr Ala Trp Phe Asn Ile Lys Ala Leu Trp Asp 
        35                  40                  45              
Pro Tyr Ala Asn Thr Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp 
    50                  55                  60                  
Lys Ser Ala Ser Phe Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val 
65                  70                  75                  80  
Leu Lys Asn Leu Lys Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp 
                85                  90                  95      
Ser Lys Ala Asp Leu Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala 
            100                 105                 110         
Gly Ile Tyr Leu Pro Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr 
        115                 120                 125             
Thr Gly Asp Ile Lys Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys 
    130                 135                 140                 
Ile Asn Ala Ile Ala Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu 
145                 150                 155                 160 
Gln Ser Gln Ile Ser Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu 
                165                 170                 175     
Leu Lys Thr Phe Asn Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val 
            180                 185                 190         
Ser Ile Gln Lys Val Lys Ser Ala Ile Leu Ser Thr Asn Asp Asn Leu 
        195                 200                 205             
Gly Thr Ile Asp Lys Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys 
    210                 215                 220                 
Met Pro Glu Ile Lys Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr 
225                 230                 235                 240 
Tyr Leu Pro Glu Val Asp Ala Leu Gly Gln Lys Val Ile Lys Leu Asn 
                245                 250                 255     
Asp Lys Met Pro Glu Ile Asp Lys Ser Phe Ser Leu Val Leu Thr Leu 
            260                 265                 270         
Gln Glu Lys Ile Pro Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met 
        275                 280                 285             
Ile Asp Asp Asp Phe Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile 
    290                 295                 300                 
Gln Glu Ala Lys Gln Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser 
305                 310                 315                 320 
Met Pro Asp Ile Lys Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr 
                325                 330                 335     
Ile Thr Leu Asp Ala Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile 
            340                 345                 350         
Thr Asn Ser Val Gln Ile Thr Leu Gln Ser Ile Gln Glu Phe Ser Lys 
        355                 360                 365             
Asn Thr Ser Ser Val Ile Ser Val Ile Asp Gln Ala Ile Ala Asp Asn 
    370                 375                 380                 
Gln Leu Thr Asp Asp Glu Lys Glu Gln Ile Asn Ser Leu Ile Thr Asn 
385                 390                 395                 400 
Phe Thr Asn Asn Ile Ala Lys Gln Arg Glu Ala Ile Gln Asn Ile Val 
                405                 410                 415     
Glu Tyr Met Lys Gln Val Gln Glu Ser Asn Gly Asn His Asp Leu Asp 
            420                 425                 430         
Ser Thr Ile Glu Gln Leu Thr Asn Leu Asp Ser Leu Leu Ser Glu Leu 
        435                 440                 445             
Ser Thr Arg Met Ser His Leu Asn Asp Leu Val Gln Glu Gly Asp Val 
    450                 455                 460                 
Thr Lys Ile Arg Ala Tyr Leu Ser Gln Ile Asn Asp Val Val Asn Asn 
465                 470                 475                 480 
Ile Ser Asp Leu Ile Asn Lys Ile Asp Val Ser Glu Ile Ser Ser Thr 
                485                 490                 495     
Ile Asn Lys Ala Leu Thr Thr Leu Ile Asn Thr Ile Thr Asp Ala Lys 
            500                 505                 510         
Gly Leu Leu Asn Gln Ala Gln Gln Ile Asp Phe Asp Ala Leu Leu Asn 
        515                 520                 525             
Ser Thr Ser Gln Thr Val Ser Asn Ala Ile Thr Ile Leu Glu Lys Tyr 
    530                 535                 540                 
Gln Gly Glu Met Pro Ala Ile Lys Gln Glu Ile His Asp Ala Asn Val 
545                 550                 555                 560 
Met Leu Asn Gly Asn Met Thr Thr Ile Val Asn Ala Ile Asn Glu Gly 
                565                 570                 575     
Ala Asn Leu Tyr Lys Asn Glu Phe Pro Thr Leu Lys Ser Lys Leu Gly 
            580                 585                 590         
Thr Ala Ser Asp Phe Phe Lys Asn Asp Tyr Ala Gly Val Arg Lys Asp 
        595                 600                 605             
Leu Thr Asp Thr Leu Thr Met Ala Asn Asp Lys Met Pro Asp Val Glu 
    610                 615                 620                 
Ser Ala Leu Asn Gln Ala Asn Asp Leu Ile Gln Asn Asp Trp Pro Glu 
625                 630                 635                 640 
Ile Lys Ser Gly Ile Gln Lys Ala Ala Ala Ala Ile Gln Lys Gly Glu 
                645                 650                 655     
Lys Glu Val Asp Leu Gly Glu Ile Val Lys Leu Leu Lys Leu Asp Ala 
            660                 665                 670         
Thr Lys Glu Ser Asp Phe Leu Thr Gln Pro Val Glu Val Gln Glu Asn 
        675                 680                 685             
Gln Ile Tyr Pro Ile Ala Asn Asn Gly Ser Ala Ser Thr Pro Phe Tyr 
    690                 695                 700                 
Thr Ala Leu Cys Leu Trp Val Gly Ala Val Leu Leu Ser Ser Leu Ala 
705                 710                 715                 720 
Thr Thr Glu Val His Leu Ser Asp Lys Asp Lys Lys Arg Tyr Ser Lys 
                725                 730                 735     
Arg Glu Gln Phe Phe Ala Arg Met Gly Ser Phe Val Ala Ile Gly Leu 
            740                 745                 750         
Ala Gln Ala Leu Ile Val Thr Leu Gly Asn Tyr Phe Gly Leu Gly Val 
        755                 760                 765             
Asp Val Arg Asp Pro Phe Tyr Ser Val Leu Phe Ala Leu Leu Ile Ser 
    770                 775                 780                 
Ile Ala Phe Met Ile Met Val Tyr Val Leu Val Ala Leu Phe Gly Asn 
785                 790                 795                 800 
Val Gly Lys Gly Ile Ala Ile Ile Ile Leu Val Leu Ser Ile Ser Gly 
                805                 810                 815     
Gly Gly Gly Asn Tyr Pro Ile Gln Val Ser Gly Lys Phe Phe Gln Ala 
            820                 825                 830         
Ile Asn Pro Tyr Leu Pro Phe Thr His Ala Val Asn Leu Leu Arg Glu 
        835                 840                 845             
Ser Ala Gly Gly Ile Tyr Trp Pro Asn Ala Trp Phe Ala Ile Ile Ile 
    850                 855                 860                 
Leu Val Ala Val Ser Ile Val Phe Val Ala Ile Gly Ala Phe Leu Phe 
865                 870                 875                 880 
Pro His Phe Glu Asp Lys Thr Lys Lys Ile Ser Glu Ile Gly Ser Lys 
                885                 890                 895     
Ser His Phe Phe His 
            900     

<210> 4
<211> 2706
<212> DNA
<213> Lactococcus lactis


<400> 4
gtgaaaagta ttaaaaatac atggaagttg tttgccctag actggaagcg aatatttaaa      60

aatcccgtgg cgactttttt aattgtcgcc ctaatgataa ttccctcttt atatgcttgg     120

tttaatatta aagccctgtg ggacccctat gccaatactt cgcaactgcc aattgcggtc     180

tatagtgcag ataaatctgc aagttttcaa gataaaacca tcaatattgg tgatgaagta     240

ctgaaaaatt taaagaaaaa tcaccaatta ggctggaaat ttgttgattc caaagcagat     300

ttagataaag gtgtgaaatc tggaaaatac tatgctggaa tctatttacc aaaggatttt     360

tcaaaagacc tcttaagttt caccacggga gatattaaaa aaccacaaat tgtttattca     420

attaacgaaa aaatcaatgc catcgctccc aaaataacat caaaaggagc ctcttctcta     480

caatcgcaaa tttctgaaga gtttatcaaa acggcaagta gtaccctttt aaaaaccttc     540

aatacaattg gttacgatat tgataaaaac atggtaagta ttcagaaggt taaatcagcg     600

attttatcaa ctaatgataa tttaggaacc attgataaat acactcaaca agttgttgat     660

cttcatggaa aaatgccaga aattaaagaa aaactggcaa aagctaatga atttatcact     720

tatttaccag aagtagatgc tttaggtcaa aaggtcatta aattaaatga taaaatgcca     780

gaaattgata aaagtttttc actcgttttg acccttcaag agaaaatacc tgagattcaa     840

aatgctggaa aacaaatctc gatgattgat gatgactttg cgtcagtaga aagtaccatg     900

actcaaggca ttcaagaagc caaacaaggt ttacaaatta tcaatcaagt ccaaaaatca     960

atgccagaca ttaaaaaatt gggacaagat gctgatagtt tggggactat aaccttggat    1020

gcggcgaaaa aaatgcagag tgcgttgcct agcattacaa atagcgttca aataacactt    1080

caatcaattc aagagttctc aaaaaatact tcatccgtta tttctgttat tgaccaagcg    1140

attgccgata atcaattaac tgatgatgaa aaggaacaaa taaatagctt aattaccaat    1200

tttactaata acattgctaa acaaagagaa gccattcaaa atattgttga atatatgaag    1260

caggtgcaag aaagcaatgg aaatcacgat ttagattcta ctattgagca attaactaat    1320

ctagattcgc tcttgtcaga acttagtacc agaatgagtc acctaaatga cttagtgcaa    1380

gagggtgatg taactaagat tcgagcttat ctatcacaaa tcaatgatgt agtaaataat    1440

atttctgatt taattaataa aattgatgtc agtgagatta gtagtacaat taataaagct    1500

ctaacaacat taattaatac cataacagac gctaaaggtt tattaaatca agctcaacaa    1560

atcgactttg atgccttact aaattcaaca agccaaacag tttctaatgc tattaccatt    1620

ttagaaaaat atcaaggcga aatgccagcc attaaacaag aaattcatga tgcgaatgtg    1680

atgttaaatg gcaatatgac aactattgtt aatgcaatca atgagggagc taatctctat    1740

aaaaatgagt ttcctactct taaaagtaag ttagggacag cttctgattt ctttaaaaat    1800

gattatgctg gtgttcgtaa agatttgaca gataccttaa caatggcaaa tgataaaatg    1860

cctgatgttg agtctgcttt gaatcaagcc aatgatttaa tccaaaatga ttggcctgaa    1920

atcaaatcag gaattcaaaa agcagccgca gctattcaaa aaggtgaaaa agaagttgac    1980

ttaggtgaaa tcgtcaaact cctaaaatta gatgcgacca aagagagcga cttcctgaca    2040

caaccagttg aagtccaaga aaatcaaatc tacccgattg ccaacaatgg ttcagcaagt    2100

acacctttct atactgcgct ttgtctgtgg gtcggtgcag tcttactttc aagtttggca    2160

acaacggagg ttcacttatc agataaagat aaaaaacgtt attctaaacg tgaacaattc    2220

tttgctcgaa tgggaagttt cgtagccatt ggacttgctc aagccttgat tgtaacgctt    2280

ggaaattatt ttggtttagg agtagatgta agagatccat tctacagtgt tctctttgcc    2340

ttactaatat ccatagcctt tatgataatg gtttatgttc tggtcgcact gtttggcaat    2400

gtaggtaaag gaatagcgat tatcatcctg gttctttcca tttctggtgg tggtgggaac    2460

tatccaatcc aagtttctgg aaaattcttc caagccatta atccttattt accatttact    2520

catgctgtca accttttacg agaatcagcg ggaggaattt actggccaaa tgcttggttt    2580

gcgataatca ttcttgtagc agtgtcaatt gtgtttgttg caataggtgc cttcctcttc    2640

ccacactttg aagataaaac gaagaaaatt tccgagatcg gaagcaagag tcatttcttc    2700

cattaa                                                               2706


<210> 5
<211> 901
<212> PRT
<213> Lactococcus lactis subsp. cremoris


<400> 5
Val Lys Ser Ile Lys Asn Thr Trp Lys Leu Phe Ala Leu Asp Trp Lys 
1               5                   10                  15      
Arg Ile Phe Lys Asn Pro Val Ala Thr Phe Leu Ile Val Ala Leu Met 
            20                  25                  30          
Ile Ile Pro Ser Leu Tyr Ala Trp Phe Asn Ile Lys Ala Leu Trp Asp 
        35                  40                  45              
Pro Tyr Ala Asn Thr Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp 
    50                  55                  60                  
Lys Pro Ala Ser Phe Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val 
65                  70                  75                  80  
Leu Lys Asn Leu Lys Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp 
                85                  90                  95      
Ser Lys Ala Glu Leu Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala 
            100                 105                 110         
Gly Ile Tyr Leu Pro Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr 
        115                 120                 125             
Thr Gly Asp Ile Lys Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys 
    130                 135                 140                 
Ile Asn Ala Ile Ala Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu 
145                 150                 155                 160 
Gln Ser Gln Ile Ser Glu Glu Phe Ile Asn Thr Ala Ser Ser Thr Leu 
                165                 170                 175     
Leu Lys Thr Phe Asn Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val 
            180                 185                 190         
Ser Ile Gln Lys Val Lys Ser Ala Ile Leu Ser Thr Asn Asp Asn Leu 
        195                 200                 205             
Gly Thr Ile Asp Lys Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys 
    210                 215                 220                 
Met Pro Glu Ile Lys Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr 
225                 230                 235                 240 
Tyr Leu Pro Glu Val Asp Ser Leu Gly Gln Lys Val Ile Ser Leu Asn 
                245                 250                 255     
Asp Lys Met Pro Glu Ile Asp Lys Ser Leu Ser Leu Val Leu Thr Leu 
            260                 265                 270         
Gln Glu Lys Ile Pro Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met 
        275                 280                 285             
Ile Asp Glu Asp Phe Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile 
    290                 295                 300                 
Gln Glu Ala Lys Asp Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser 
305                 310                 315                 320 
Met Pro Asp Ile Gln Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr 
                325                 330                 335     
Val Thr Leu Asp Ala Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile 
            340                 345                 350         
Thr Asn Ser Val Gln Ile Thr Leu Gln Ser Ile Gln Glu Phe Ser Lys 
        355                 360                 365             
Asn Thr Ser Ser Val Leu Ala Val Ile Asp Gln Ala Ile Ala Asp Asn 
    370                 375                 380                 
Gln Leu Thr Asp Glu Glu Lys Glu Gln Ile Asn Ser Leu Ile Thr Asn 
385                 390                 395                 400 
Phe Ile Asn Asn Ile Ala Arg Gln Arg Glu Ala Ile Gln Asn Ile Val 
                405                 410                 415     
Asp Tyr Met Lys Gln Val Gln Glu Ser Asn Gly Ser His Asp Leu Asp 
            420                 425                 430         
Ser Thr Ile Glu Gln Leu Ser Asn Leu Asp Ser Leu Leu Ser Gly Leu 
        435                 440                 445             
Ser Thr Arg Met Asn His Leu Asn Glu Leu Val Gln Asn Gly Asp Val 
    450                 455                 460                 
Ser Glu Ile Arg Ala Tyr Leu Ser Gln Ile Asn Asp Val Val Thr Lys 
465                 470                 475                 480 
Ile Ser Asn Leu Val Asp Asn Ile Asp Val Ser Gly Ile Ser Lys Thr 
                485                 490                 495     
Ile Asp Thr Val Leu Thr Ser Leu Thr Lys Thr Ile Thr Asp Ala Lys 
            500                 505                 510         
Gly Leu Leu Asn Gln Ala Gln Gln Ile Asp Phe Glu Ala Leu Leu Asn 
        515                 520                 525             
Ser Thr Ser Gln Thr Val Ser Asn Ala Val Thr Ile Leu Glu Lys Tyr 
    530                 535                 540                 
Gln Gly Glu Met Pro Ala Ile Lys Gln Glu Ile His Asp Ala Asn Leu 
545                 550                 555                 560 
Met Leu Asn Gly Asn Met Thr Thr Ile Val Asn Ala Ile Asn Glu Gly 
                565                 570                 575     
Ala Ser Leu Tyr Lys Asn Glu Phe Pro Ile Leu Lys Thr Lys Leu Gly 
            580                 585                 590         
Thr Ala Ser Asp Phe Phe Lys Asn Asp Tyr Ala Gly Val Arg Lys Asp 
        595                 600                 605             
Leu Thr Asp Thr Leu Thr Met Ala Asn Glu Lys Met Pro Asp Val Glu 
    610                 615                 620                 
Ser Ala Leu Asn Gln Ala Asn Ser Leu Ile Gln Asn Asp Trp Pro Glu 
625                 630                 635                 640 
Ile Lys Ser Gly Ile Gln Lys Ala Ala Thr Ala Ile Gln Lys Gly Glu 
                645                 650                 655     
Lys Glu Val Asp Leu Gly Glu Ile Val Lys Leu Leu Lys Leu Asp Ala 
            660                 665                 670         
Thr Lys Glu Ser Asp Phe Leu Thr Gln Pro Val Glu Val Gln Glu Asn 
        675                 680                 685             
Gln Val Tyr Pro Ile Ala Asn Asn Gly Ser Ala Ser Thr Pro Phe Tyr 
    690                 695                 700                 
Thr Ala Leu Cys Leu Trp Val Gly Ala Val Leu Leu Ser Ser Leu Ala 
705                 710                 715                 720 
Thr Thr Glu Val His Leu Ser Asp Lys Asp Lys Lys Arg Tyr Ser Lys 
                725                 730                 735     
Arg Glu Gln Phe Phe Ala Arg Met Gly Ser Phe Val Ala Ile Gly Leu 
            740                 745                 750         
Ala Gln Ala Leu Ile Val Thr Leu Gly Asn Tyr Phe Gly Leu Gly Val 
        755                 760                 765             
Asp Val Arg Asp Pro Phe Tyr Ser Val Leu Phe Ala Leu Leu Ile Ser 
    770                 775                 780                 
Ile Ala Phe Met Ile Met Val Tyr Val Leu Val Ala Leu Phe Gly Asn 
785                 790                 795                 800 
Val Gly Lys Gly Ile Ala Ile Ile Ile Leu Val Leu Ser Ile Ser Gly 
                805                 810                 815     
Gly Gly Gly Asn Tyr Pro Ile Gln Val Ser Gly Lys Phe Phe Gln Ala 
            820                 825                 830         
Ile Asn Pro Tyr Leu Pro Phe Thr His Ala Val Asn Leu Leu Arg Glu 
        835                 840                 845             
Ser Ala Gly Gly Ile Tyr Trp Pro Asn Ala Trp Phe Ala Ile Ile Ile 
    850                 855                 860                 
Leu Val Ala Val Ser Ile Ile Phe Val Ala Ile Gly Ala Ile Leu Phe 
865                 870                 875                 880 
Pro His Phe Glu Asp Lys Thr Lys Lys Ile Ser Glu Ile Gly Ser Lys 
                885                 890                 895     
Ser His Phe Phe His 
            900     

<210> 6
<211> 2706
<212> DNA
<213> Lactococcus lactis subsp. cremoris


<400> 6
gtgaaaagta taaaaaatac ctggaagttg tttgccctag actggaaacg aatttttaaa      60

aatcctgtgg cgaccttttt aatcgttgcc ttaatgataa ttccctcttt atatgcttgg     120

tttaacatta aagccttgtg ggacccttat gccaatacct cgcaattgcc aattgcagtc     180

tacagtgcag ataaacctgc tagttttcaa gataaaacca taaacattgg tgatgaagtt     240

ctgaagaatt taaagaaaaa tcatcaatta ggttggaaat ttgtagattc taaagcagaa     300

ttagataaag gagttaaatc cggaaaatac tatgctggaa tttacttacc aaaggatttt     360

tcaaaagacc ttttaagttt tacaaccggt gatattaaaa agccacaaat agtttattct     420

attaatgaaa agataaatgc tattgctccc aaaataacct ctaagggtgc ttcatctctt     480

caatcacaga tttctgaaga gtttattaat acggcaagta gtacactctt aaaaaccttt     540

aatacgattg gttacgatat tgataaaaat atggtcagca ttcaaaaggt taagtcagca     600

attttatcaa caaacgataa tctaggaacc attgacaaat acacccaaca agtggttgac     660

cttcatggta aaatgccaga aatcaaagaa aaactggcta aggctaacga atttattact     720

tatttacccg aagttgattc tttaggtcaa aaagtaatta gtttgaatga taaaatgcct     780

gaaattgata aaagtttgtc acttgttttg actcttcaag aaaaaattcc tgaaattcaa     840

aacgctggta aacaaatttc gatgattgat gaagactttg cgtcagttga aagtactatg     900

acccaaggaa ttcaagaagc aaaagacggc ttgcaaatca tcaatcaagt ccaaaaatca     960

atgccagaca ttcaaaaatt aggacaagat gcagatagtt tagggactgt gacattggat    1020

gcagcgaaaa aaatgcagag cgcattgcct agtatcacga atagcgttca aatcactcta    1080

cagtctattc aagaattttc aaaaaatact tcctcagttc tcgctgttat tgaccaagca    1140

atagctgata atcagctcac agatgaagaa aaagaacaaa taaatagttt aattaccaac    1200

tttattaaca atatcgcccg acaaagagaa gcaattcaaa atattgttga ttacatgaaa    1260

caagtccaag agagcaatgg aagtcatgat ttagactcaa caattgagca actcagtaat    1320

cttgattctt tactgtcagg acttagtact agaatgaatc atctgaatga gttagtacaa    1380

aatggtgatg tatctgaaat tcgtgcttac ttatcccaaa ttaatgatgt ggttactaaa    1440

atctctaatt tagttgataa tattgatgtg agtggaatta gtaaaacaat tgatacagtt    1500

ttaacaagct tgactaaaac aatcactgat gccaaaggtt tattaaatca agctcaacaa    1560

attgactttg aagctttact aaattcaaca agtcaaacag tttctaatgc tgttaccatt    1620

ttagaaaaat atcaaggtga aatgccagcc atcaaacaag aaattcatga tgcaaacttg    1680

atgttaaatg gaaatatgac gacaattgtc aatgcaatta acgaaggggc tagtctttat    1740

aaaaatgagt tccctatcct taaaactaag ttgggcacag cttctgattt ctttaaaaat    1800

gattatgctg gtgttcgtaa agatttaaca gataccttaa caatggcaaa tgagaaaatg    1860

cctgacgtcg agtctgcttt gaatcaagcc aatagtttaa tccaaaatga ctggcctgaa    1920

atcaaatcgg gcattcaaaa agcagcaaca gccattcaaa aaggtgaaaa agaagttgat    1980

ttaggagaga ttgttaaact tctaaaactt gatgctacta aagagagtga ctttttgacc    2040

caaccagtag aagtgcaaga aaatcaagtt tatcctattg ccaacaatgg ttcggcaagt    2100

acacctttct acacagcgct ttgtctgtgg gtcggtgcag tcttactttc aagtttggca    2160

acaacagagg ttcatctatc agataaagat aaaaaacgtt attctaaacg tgaacaattc    2220

tttgctcgaa tgggaagttt cgtagccatt ggacttgctc aagccttgat tgtaacctta    2280

ggaaactact ttggtttagg ggtagatgta cgagacccat tctacagcgt cctctttgcc    2340

ttactgatat ccatcgcctt tatgataatg gtttatgttc tagtcgcgct atttggtaat    2400

gttggtaaag gaatagcgat tattatcctt gtactttcca tttctggtgg tggtgggaac    2460

tatccaatcc aagtttctgg aaaattcttc caagccatta atccttattt accatttacc    2520

cacgctgtta atcttttacg agaatcggct ggagggattt attggccaaa cgcttggttt    2580

gcaataatta tccttgtggc agtatcaatt atatttgttg caattggggc cattctcttc    2640

ccacactttg aagataaaac gaagaaaatt tctgaaatcg gaagtaagag tcatttcttc    2700

cattaa                                                               2706


<210> 7
<211> 901
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 7
Val Lys Ser Ile Lys Asn Thr Trp Lys Leu Phe Ala Leu Asp Trp Lys 
1               5                   10                  15      
Arg Ile Phe Lys Asn Pro Val Ala Thr Phe Leu Ile Val Ala Leu Met 
            20                  25                  30          
Ile Ile Pro Ser Leu Tyr Ala Trp Phe Asn Ile Lys Ala Leu Trp Asp 
        35                  40                  45              
Pro Tyr Ala Asn Thr Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp 
    50                  55                  60                  
Lys Ser Ala Ser Phe Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val 
65                  70                  75                  80  
Leu Lys Asn Leu Lys Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp 
                85                  90                  95      
Ser Lys Ala Asp Leu Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala 
            100                 105                 110         
Gly Ile Tyr Leu Pro Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr 
        115                 120                 125             
Thr Gly Asp Ile Lys Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys 
    130                 135                 140                 
Ile Asn Ala Ile Ala Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu 
145                 150                 155                 160 
Gln Ser Gln Ile Ser Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu 
                165                 170                 175     
Leu Lys Thr Phe Asn Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val 
            180                 185                 190         
Ser Ile Gln Lys Val Lys Ser Val Ile Leu Ser Thr Asn Asp Asn Leu 
        195                 200                 205             
Gly Thr Ile Asp Lys Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys 
    210                 215                 220                 
Met Pro Glu Ile Lys Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr 
225                 230                 235                 240 
Tyr Leu Pro Glu Val Asp Ala Leu Gly Gln Lys Val Ile Lys Leu Asn 
                245                 250                 255     
Asp Lys Met Pro Glu Ile Asp Lys Ser Phe Ser Leu Val Leu Thr Leu 
            260                 265                 270         
Gln Glu Lys Ile Pro Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met 
        275                 280                 285             
Ile Asp Asp Asp Phe Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile 
    290                 295                 300                 
Gln Glu Ala Lys Gln Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser 
305                 310                 315                 320 
Met Pro Asp Ile Lys Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr 
                325                 330                 335     
Ile Thr Leu Asp Ala Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile 
            340                 345                 350         
Thr Asn Ser Val Gln Ile Thr Leu Gln Ser Ile Gln Glu Phe Ser Lys 
        355                 360                 365             
Asn Thr Ser Ser Val Ile Ser Val Ile Asp Gln Ala Ile Ala Asp Asn 
    370                 375                 380                 
Gln Leu Thr Asp Asp Glu Lys Glu Gln Ile Asn Ser Leu Ile Thr Asn 
385                 390                 395                 400 
Phe Thr Asn Asn Ile Ala Lys Gln Arg Glu Ala Ile Gln Asn Ile Val 
                405                 410                 415     
Glu Tyr Met Lys Gln Val Gln Glu Ser Asn Gly Asn His Asp Leu Asp 
            420                 425                 430         
Ser Thr Ile Glu Gln Leu Thr Asn Leu Asp Ser Leu Leu Ser Glu Leu 
        435                 440                 445             
Ser Thr Arg Met Ser His Leu Asn Asp Leu Val Gln Glu Gly Asp Val 
    450                 455                 460                 
Thr Lys Ile Arg Ala Tyr Leu Ser Gln Ile Asn Asp Val Val Asn Asn 
465                 470                 475                 480 
Ile Ser Asp Leu Ile Asn Lys Ile Asp Val Ser Glu Ile Ser Ser Thr 
                485                 490                 495     
Ile Asn Lys Ala Leu Thr Thr Leu Ile Asn Thr Ile Thr Asp Ala Lys 
            500                 505                 510         
Gly Leu Leu Asn Gln Ala Gln Gln Ile Asp Phe Asp Ala Leu Leu Asn 
        515                 520                 525             
Ser Thr Ser Gln Thr Val Ser Asn Ala Ile Thr Ile Leu Glu Lys Tyr 
    530                 535                 540                 
Gln Gly Glu Met Pro Ala Ile Lys Gln Glu Ile His Asp Ala Asn Val 
545                 550                 555                 560 
Met Leu Asn Gly Asn Met Thr Thr Ile Val Asn Ala Ile Asn Glu Gly 
                565                 570                 575     
Ala Asn Leu Tyr Lys Asn Glu Phe Pro Thr Leu Lys Ser Lys Leu Gly 
            580                 585                 590         
Thr Ala Ser Asp Phe Phe Lys Asn Asp Tyr Ala Gly Val Arg Lys Asp 
        595                 600                 605             
Leu Thr Asp Thr Leu Thr Met Ala Asn Asp Lys Met Pro Asp Val Glu 
    610                 615                 620                 
Ser Ala Leu Asn Gln Ala Asn Asp Leu Ile Gln Asn Asp Trp Pro Glu 
625                 630                 635                 640 
Ile Lys Ser Gly Ile Gln Lys Ala Ala Ala Ala Ile Gln Lys Gly Glu 
                645                 650                 655     
Lys Glu Val Asp Leu Gly Glu Ile Val Lys Leu Leu Lys Leu Asp Ala 
            660                 665                 670         
Thr Lys Glu Ser Asp Phe Leu Thr Gln Pro Val Glu Val Gln Glu Asn 
        675                 680                 685             
Gln Ile Tyr Pro Ile Ala Asn Asn Gly Ser Ala Ser Thr Pro Phe Tyr 
    690                 695                 700                 
Thr Ala Leu Cys Leu Trp Val Gly Ala Val Leu Leu Ser Ser Leu Ala 
705                 710                 715                 720 
Thr Thr Glu Val His Leu Ser Asp Lys Asp Lys Lys Arg Tyr Ser Lys 
                725                 730                 735     
Arg Glu Gln Phe Phe Ala Arg Met Gly Ser Phe Val Ala Ile Gly Leu 
            740                 745                 750         
Ala Gln Ala Leu Ile Val Thr Leu Gly Asn Tyr Phe Gly Leu Gly Val 
        755                 760                 765             
Asp Val Arg Asp Pro Phe Tyr Ser Val Leu Phe Ala Leu Leu Ile Ser 
    770                 775                 780                 
Ile Ala Phe Met Ile Met Val Tyr Val Leu Val Ala Leu Phe Gly Asn 
785                 790                 795                 800 
Val Gly Lys Gly Ile Ala Ile Ile Ile Leu Val Leu Ser Ile Ser Gly 
                805                 810                 815     
Gly Gly Gly Asn Tyr Pro Ile Gln Val Ser Gly Lys Phe Phe Gln Ala 
            820                 825                 830         
Ile Asn Pro Tyr Leu Pro Phe Thr His Ala Val Asn Leu Leu Arg Glu 
        835                 840                 845             
Ser Ala Gly Gly Ile Tyr Trp Pro Asn Ala Trp Phe Ala Ile Ile Ile 
    850                 855                 860                 
Leu Val Ala Val Ser Ile Val Phe Val Ala Ile Gly Ala Phe Leu Phe 
865                 870                 875                 880 
Pro His Phe Glu Asp Lys Thr Lys Lys Ile Ser Glu Ile Gly Ser Lys 
                885                 890                 895     
Ser His Phe Phe His 
            900     

<210> 8
<211> 856
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 8
Val Gly Asp Pro Tyr Ala Asn Thr Ser Gln Leu Pro Ile Ala Val Tyr 
1               5                   10                  15      
Ser Ala Asp Lys Ser Ala Ser Phe Gln Asp Lys Thr Ile Asn Ile Gly 
            20                  25                  30          
Asp Glu Val Leu Lys Asn Leu Lys Lys Asn His Gln Leu Gly Trp Lys 
        35                  40                  45              
Phe Val Asp Ser Lys Ala Asp Leu Asp Lys Gly Val Lys Ser Gly Lys 
    50                  55                  60                  
Tyr Tyr Ala Gly Ile Tyr Leu Pro Lys Asp Phe Ser Lys Asp Leu Leu 
65                  70                  75                  80  
Ser Phe Thr Thr Gly Asp Ile Lys Lys Pro Gln Ile Val Tyr Ser Ile 
                85                  90                  95      
Asn Glu Lys Ile Asn Ala Ile Ala Pro Lys Ile Thr Ser Lys Gly Ala 
            100                 105                 110         
Ser Ser Leu Gln Ser Gln Ile Ser Glu Glu Phe Ile Lys Thr Ala Ser 
        115                 120                 125             
Ser Thr Leu Leu Lys Thr Phe Asn Thr Ile Gly Tyr Asp Ile Asp Lys 
    130                 135                 140                 
Asn Met Val Ser Ile Gln Lys Val Lys Ser Val Ile Leu Ser Thr Asn 
145                 150                 155                 160 
Asp Asn Leu Gly Thr Ile Asp Lys Tyr Thr Gln Gln Val Val Asp Leu 
                165                 170                 175     
His Gly Lys Met Pro Glu Ile Lys Glu Lys Leu Ala Lys Ala Asn Glu 
            180                 185                 190         
Phe Ile Thr Tyr Leu Pro Glu Val Asp Ala Leu Gly Gln Lys Val Ile 
        195                 200                 205             
Lys Leu Asn Asp Lys Met Pro Glu Ile Asp Lys Ser Phe Ser Leu Val 
    210                 215                 220                 
Leu Thr Leu Gln Glu Lys Ile Pro Glu Ile Gln Asn Ala Gly Lys Gln 
225                 230                 235                 240 
Ile Ser Met Ile Asp Asp Asp Phe Ala Ser Val Glu Ser Thr Met Thr 
                245                 250                 255     
Gln Gly Ile Gln Glu Ala Lys Gln Gly Leu Gln Ile Ile Asn Gln Val 
            260                 265                 270         
Gln Lys Ser Met Pro Asp Ile Lys Lys Leu Gly Gln Asp Ala Asp Ser 
        275                 280                 285             
Leu Gly Thr Ile Thr Leu Asp Ala Ala Lys Lys Met Gln Ser Ala Leu 
    290                 295                 300                 
Pro Ser Ile Thr Asn Ser Val Gln Ile Thr Leu Gln Ser Ile Gln Glu 
305                 310                 315                 320 
Phe Ser Lys Asn Thr Ser Ser Val Ile Ser Val Ile Asp Gln Ala Ile 
                325                 330                 335     
Ala Asp Asn Gln Leu Thr Asp Asp Glu Lys Glu Gln Ile Asn Ser Leu 
            340                 345                 350         
Ile Thr Asn Phe Thr Asn Asn Ile Ala Lys Gln Arg Glu Ala Ile Gln 
        355                 360                 365             
Asn Ile Val Glu Tyr Met Lys Gln Val Gln Glu Ser Asn Gly Asn His 
    370                 375                 380                 
Asp Leu Asp Ser Thr Ile Glu Gln Leu Thr Asn Leu Asp Ser Leu Leu 
385                 390                 395                 400 
Ser Glu Leu Ser Thr Arg Met Ser His Leu Asn Asp Leu Val Gln Glu 
                405                 410                 415     
Gly Asp Val Thr Lys Ile Arg Ala Tyr Leu Ser Gln Ile Asn Asp Val 
            420                 425                 430         
Val Asn Asn Ile Ser Asp Leu Ile Asn Lys Ile Asp Val Ser Glu Ile 
        435                 440                 445             
Ser Ser Thr Ile Asn Lys Ala Leu Thr Thr Leu Ile Asn Thr Ile Thr 
    450                 455                 460                 
Asp Ala Lys Gly Leu Leu Asn Gln Ala Gln Gln Ile Asp Phe Asp Ala 
465                 470                 475                 480 
Leu Leu Asn Ser Thr Ser Gln Thr Val Ser Asn Ala Ile Thr Ile Leu 
                485                 490                 495     
Glu Lys Tyr Gln Gly Glu Met Pro Ala Ile Lys Gln Glu Ile His Asp 
            500                 505                 510         
Ala Asn Val Met Leu Asn Gly Asn Met Thr Thr Ile Val Asn Ala Ile 
        515                 520                 525             
Asn Glu Gly Ala Asn Leu Tyr Lys Asn Glu Phe Pro Thr Leu Lys Ser 
    530                 535                 540                 
Lys Leu Gly Thr Ala Ser Asp Phe Phe Lys Asn Asp Tyr Ala Gly Val 
545                 550                 555                 560 
Arg Lys Asp Leu Thr Asp Thr Leu Thr Met Ala Asn Asp Lys Met Pro 
                565                 570                 575     
Asp Val Glu Ser Ala Leu Asn Gln Ala Asn Asp Leu Ile Gln Asn Asp 
            580                 585                 590         
Trp Pro Glu Ile Lys Ser Gly Ile Gln Lys Ala Ala Ala Ala Ile Gln 
        595                 600                 605             
Lys Gly Glu Lys Glu Val Asp Leu Gly Glu Ile Val Lys Leu Leu Lys 
    610                 615                 620                 
Leu Asp Ala Thr Lys Glu Ser Asp Phe Leu Thr Gln Pro Val Glu Val 
625                 630                 635                 640 
Gln Glu Asn Gln Ile Tyr Pro Ile Ala Asn Asn Gly Ser Ala Ser Thr 
                645                 650                 655     
Pro Phe Tyr Thr Ala Leu Cys Leu Trp Val Gly Ala Val Leu Leu Ser 
            660                 665                 670         
Ser Leu Ala Thr Thr Glu Val His Leu Ser Asp Lys Asp Lys Lys Arg 
        675                 680                 685             
Tyr Ser Lys Arg Glu Gln Phe Phe Ala Arg Met Gly Ser Phe Val Ala 
    690                 695                 700                 
Ile Gly Leu Ala Gln Ala Leu Ile Val Thr Leu Gly Asn Tyr Phe Gly 
705                 710                 715                 720 
Leu Gly Val Asp Val Arg Asp Pro Phe Tyr Ser Val Leu Phe Ala Leu 
                725                 730                 735     
Leu Ile Ser Ile Ala Phe Met Ile Met Val Tyr Val Leu Val Ala Leu 
            740                 745                 750         
Phe Gly Asn Val Gly Lys Gly Ile Ala Ile Ile Ile Leu Val Leu Ser 
        755                 760                 765             
Ile Ser Gly Gly Gly Gly Asn Tyr Pro Ile Gln Val Ser Gly Lys Phe 
    770                 775                 780                 
Phe Gln Ala Ile Asn Pro Tyr Leu Pro Phe Thr His Ala Val Asn Leu 
785                 790                 795                 800 
Leu Arg Glu Ser Ala Gly Gly Ile Tyr Trp Pro Asn Ala Trp Phe Ala 
                805                 810                 815     
Ile Ile Ile Leu Val Ala Val Ser Ile Val Phe Val Ala Ile Gly Ala 
            820                 825                 830         
Phe Leu Phe Pro His Phe Glu Asp Lys Thr Lys Lys Ile Ser Glu Ile 
        835                 840                 845             
Gly Ser Lys Ser His Phe Phe His 
    850                 855     

<210> 9
<211> 244
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 9
Val Lys Ser Ile Lys Asn Thr Trp Lys Leu Phe Ala Leu Asp Trp Lys 
1               5                   10                  15      
Arg Ile Phe Lys Asn Pro Val Ala Thr Phe Leu Ile Val Ala Leu Met 
            20                  25                  30          
Ile Ile Pro Ser Leu Tyr Ala Trp Phe Asn Ile Lys Ala Leu Trp Asp 
        35                  40                  45              
Pro Tyr Ala Asn Thr Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp 
    50                  55                  60                  
Lys Ser Ala Ser Phe Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val 
65                  70                  75                  80  
Leu Lys Asn Leu Lys Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp 
                85                  90                  95      
Ser Lys Ala Asp Leu Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala 
            100                 105                 110         
Gly Ile Tyr Leu Pro Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr 
        115                 120                 125             
Thr Gly Asp Ile Lys Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys 
    130                 135                 140                 
Ile Asn Ala Ile Ala Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu 
145                 150                 155                 160 
Gln Ser Gln Ile Ser Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu 
                165                 170                 175     
Leu Lys Thr Phe Asn Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val 
            180                 185                 190         
Ser Ile Gln Lys Val Lys Ser Val Ile Leu Ser Thr Asn Asp Asn Leu 
        195                 200                 205             
Gly Thr Ile Asp Lys Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys 
    210                 215                 220                 
Cys Gln Lys Leu Lys Lys Asn Trp Gln Lys Leu Met Asn Leu Ser Leu 
225                 230                 235                 240 
Ile Tyr Gln Lys 
                

<210> 10
<211> 864
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 10
Met Leu Gly Leu Ile Leu Lys Pro Cys Gly Asp Pro Tyr Ala Asn Thr 
1               5                   10                  15      
Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp Lys Ser Ala Ser Phe 
            20                  25                  30          
Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val Leu Lys Asn Leu Lys 
        35                  40                  45              
Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp Ser Lys Ala Asp Leu 
    50                  55                  60                  
Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala Gly Ile Tyr Leu Pro 
65                  70                  75                  80  
Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr Thr Gly Asp Ile Lys 
                85                  90                  95      
Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys Ile Asn Ala Ile Ala 
            100                 105                 110         
Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu Gln Ser Gln Ile Ser 
        115                 120                 125             
Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu Leu Lys Thr Phe Asn 
    130                 135                 140                 
Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val Ser Ile Gln Lys Val 
145                 150                 155                 160 
Lys Ser Val Ile Leu Ser Thr Asn Asp Asn Leu Gly Thr Ile Asp Lys 
                165                 170                 175     
Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys Met Pro Glu Ile Lys 
            180                 185                 190         
Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr Tyr Leu Pro Glu Val 
        195                 200                 205             
Asp Ala Leu Gly Gln Lys Val Ile Lys Leu Asn Asp Lys Met Pro Glu 
    210                 215                 220                 
Ile Asp Lys Ser Phe Ser Leu Val Leu Thr Leu Gln Glu Lys Ile Pro 
225                 230                 235                 240 
Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met Ile Asp Asp Asp Phe 
                245                 250                 255     
Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile Gln Glu Ala Lys Gln 
            260                 265                 270         
Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser Met Pro Asp Ile Lys 
        275                 280                 285             
Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr Ile Thr Leu Asp Ala 
    290                 295                 300                 
Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile Thr Asn Ser Val Gln 
305                 310                 315                 320 
Ile Thr Leu Gln Ser Ile Gln Glu Phe Ser Lys Asn Thr Ser Ser Val 
                325                 330                 335     
Ile Ser Val Ile Asp Gln Ala Ile Ala Asp Asn Gln Leu Thr Asp Asp 
            340                 345                 350         
Glu Lys Glu Gln Ile Asn Ser Leu Ile Thr Asn Phe Thr Asn Asn Ile 
        355                 360                 365             
Ala Lys Gln Arg Glu Ala Ile Gln Asn Ile Val Glu Tyr Met Lys Gln 
    370                 375                 380                 
Val Gln Glu Ser Asn Gly Asn His Asp Leu Asp Ser Thr Ile Glu Gln 
385                 390                 395                 400 
Leu Thr Asn Leu Asp Ser Leu Leu Ser Glu Leu Ser Thr Arg Met Ser 
                405                 410                 415     
His Leu Asn Asp Leu Val Gln Glu Gly Asp Val Thr Lys Ile Arg Ala 
            420                 425                 430         
Tyr Leu Ser Gln Ile Asn Asp Val Val Asn Asn Ile Ser Asp Leu Ile 
        435                 440                 445             
Asn Lys Ile Asp Val Ser Glu Ile Ser Ser Thr Ile Asn Lys Ala Leu 
    450                 455                 460                 
Thr Thr Leu Ile Asn Thr Ile Thr Asp Ala Lys Gly Leu Leu Asn Gln 
465                 470                 475                 480 
Ala Gln Gln Ile Asp Phe Asp Ala Leu Leu Asn Ser Thr Ser Gln Thr 
                485                 490                 495     
Val Ser Asn Ala Ile Thr Ile Leu Glu Lys Tyr Gln Gly Glu Met Pro 
            500                 505                 510         
Ala Ile Lys Gln Glu Ile His Asp Ala Asn Val Met Leu Asn Gly Asn 
        515                 520                 525             
Met Thr Thr Ile Val Asn Ala Ile Asn Glu Gly Ala Asn Leu Tyr Lys 
    530                 535                 540                 
Asn Glu Phe Pro Thr Leu Lys Ser Lys Leu Gly Thr Ala Ser Asp Phe 
545                 550                 555                 560 
Phe Lys Asn Asp Tyr Ala Gly Val Arg Lys Asp Leu Thr Asp Thr Leu 
                565                 570                 575     
Thr Met Ala Asn Asp Lys Met Pro Asp Val Glu Ser Ala Leu Asn Gln 
            580                 585                 590         
Ala Asn Asp Leu Ile Gln Asn Asp Trp Pro Glu Ile Lys Ser Gly Ile 
        595                 600                 605             
Gln Lys Ala Ala Ala Ala Ile Gln Lys Gly Glu Lys Glu Val Asp Leu 
    610                 615                 620                 
Gly Glu Ile Val Lys Leu Leu Lys Leu Asp Ala Thr Lys Glu Ser Asp 
625                 630                 635                 640 
Phe Leu Thr Gln Pro Val Glu Val Gln Glu Asn Gln Ile Tyr Pro Ile 
                645                 650                 655     
Ala Asn Asn Gly Ser Ala Ser Thr Pro Phe Tyr Thr Ala Leu Cys Leu 
            660                 665                 670         
Trp Val Gly Ala Val Leu Leu Ser Ser Leu Ala Thr Thr Glu Val His 
        675                 680                 685             
Leu Ser Asp Lys Asp Lys Lys Arg Tyr Ser Lys Arg Glu Gln Phe Phe 
    690                 695                 700                 
Ala Arg Met Gly Ser Phe Val Ala Ile Gly Leu Ala Gln Ala Leu Ile 
705                 710                 715                 720 
Val Thr Leu Gly Asn Tyr Phe Gly Leu Gly Val Asp Val Arg Asp Pro 
                725                 730                 735     
Phe Tyr Ser Val Leu Phe Ala Leu Leu Ile Ser Ile Ala Phe Met Ile 
            740                 745                 750         
Met Val Tyr Val Leu Val Ala Leu Phe Gly Asn Val Gly Lys Gly Ile 
        755                 760                 765             
Ala Ile Ile Ile Leu Val Leu Ser Ile Ser Gly Gly Gly Gly Asn Tyr 
    770                 775                 780                 
Pro Ile Gln Val Ser Gly Lys Phe Phe Gln Ala Ile Asn Pro Tyr Leu 
785                 790                 795                 800 
Pro Phe Thr His Ala Val Asn Leu Leu Arg Glu Ser Ala Gly Gly Ile 
                805                 810                 815     
Tyr Trp Pro Asn Ala Trp Phe Ala Ile Ile Ile Leu Val Ala Val Ser 
            820                 825                 830         
Ile Val Phe Val Ala Ile Gly Ala Phe Leu Phe Pro His Phe Glu Asp 
        835                 840                 845             
Lys Thr Lys Lys Ile Ser Glu Ile Gly Ser Lys Ser His Phe Phe His 
    850                 855                 860                 



<210> 11
<211> 864
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 11
Met Leu Gly Leu Ile Leu Lys Pro Cys Gly Asp Pro Tyr Ala Asn Thr 
1               5                   10                  15      
Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp Lys Ser Ala Ser Phe 
            20                  25                  30          
Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val Leu Lys Asn Leu Lys 
        35                  40                  45              
Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp Ser Lys Ala Asp Leu 
    50                  55                  60                  
Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala Gly Ile Tyr Leu Pro 
65                  70                  75                  80  
Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr Thr Gly Asp Ile Lys 
                85                  90                  95      
Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys Ile Asn Ala Ile Ala 
            100                 105                 110         
Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu Gln Ser Gln Ile Ser 
        115                 120                 125             
Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu Leu Lys Thr Phe Asn 
    130                 135                 140                 
Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val Ser Ile Gln Lys Val 
145                 150                 155                 160 
Lys Ser Val Ile Leu Ser Thr Asn Asp Asn Leu Gly Thr Ile Asp Lys 
                165                 170                 175     
Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys Met Pro Glu Ile Lys 
            180                 185                 190         
Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr Tyr Leu Pro Glu Val 
        195                 200                 205             
Asp Ala Leu Gly Gln Lys Val Ile Lys Leu Asn Asp Lys Met Pro Glu 
    210                 215                 220                 
Ile Asp Lys Ser Phe Ser Leu Val Leu Thr Leu Gln Glu Lys Ile Pro 
225                 230                 235                 240 
Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met Ile Asp Asp Asp Phe 
                245                 250                 255     
Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile Gln Glu Ala Lys Gln 
            260                 265                 270         
Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser Met Pro Asp Ile Lys 
        275                 280                 285             
Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr Ile Thr Leu Asp Ala 
    290                 295                 300                 
Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile Thr Asn Ser Val Gln 
305                 310                 315                 320 
Ile Thr Leu Gln Ser Ile Gln Glu Phe Ser Lys Asn Thr Ser Ser Val 
                325                 330                 335     
Ile Ser Val Ile Asp Gln Ala Ile Ala Asp Asn Gln Leu Thr Asp Asp 
            340                 345                 350         
Glu Lys Glu Gln Ile Asn Ser Leu Ile Thr Asn Phe Thr Asn Asn Ile 
        355                 360                 365             
Ala Lys Gln Arg Glu Ala Ile Gln Asn Ile Val Glu Tyr Met Lys Gln 
    370                 375                 380                 
Val Gln Glu Ser Asn Gly Asn His Asp Leu Asp Ser Thr Ile Glu Gln 
385                 390                 395                 400 
Leu Thr Asn Leu Asp Ser Leu Leu Ser Glu Leu Ser Thr Arg Met Ser 
                405                 410                 415     
His Leu Asn Asp Leu Val Gln Glu Gly Asp Val Thr Lys Ile Arg Ala 
            420                 425                 430         
Tyr Leu Ser Gln Ile Asn Asp Val Val Asn Asn Ile Ser Asp Leu Ile 
        435                 440                 445             
Asn Lys Ile Asp Val Ser Glu Ile Ser Ser Thr Ile Asn Lys Ala Leu 
    450                 455                 460                 
Thr Thr Leu Ile Asn Thr Ile Thr Asp Ala Lys Gly Leu Leu Asn Gln 
465                 470                 475                 480 
Ala Gln Gln Ile Asp Phe Asp Ala Leu Leu Asn Ser Thr Ser Gln Thr 
                485                 490                 495     
Val Ser Asn Ala Ile Thr Ile Leu Glu Lys Tyr Gln Gly Glu Met Pro 
            500                 505                 510         
Ala Ile Lys Gln Glu Ile His Asp Ala Asn Val Met Leu Asn Gly Asn 
        515                 520                 525             
Met Thr Thr Ile Val Asn Ala Ile Asn Glu Gly Ala Asn Leu Tyr Lys 
    530                 535                 540                 
Asn Glu Phe Pro Thr Leu Lys Ser Lys Leu Gly Thr Ala Ser Asp Phe 
545                 550                 555                 560 
Phe Lys Asn Asp Tyr Ala Gly Val Arg Lys Asp Leu Thr Asp Thr Leu 
                565                 570                 575     
Thr Met Ala Asn Asp Lys Met Pro Asp Val Glu Ser Ala Leu Asn Gln 
            580                 585                 590         
Ala Asn Asp Leu Ile Gln Asn Asp Trp Pro Glu Ile Lys Ser Gly Ile 
        595                 600                 605             
Gln Lys Ala Ala Ala Ala Ile Gln Lys Gly Glu Lys Glu Val Asp Leu 
    610                 615                 620                 
Gly Glu Ile Val Lys Leu Leu Lys Leu Asp Ala Thr Lys Glu Ser Asp 
625                 630                 635                 640 
Phe Leu Thr Gln Pro Val Glu Val Gln Glu Asn Gln Ile Tyr Pro Ile 
                645                 650                 655     
Ala Asn Asn Gly Ser Ala Ser Thr Pro Phe Tyr Thr Ala Leu Cys Leu 
            660                 665                 670         
Trp Val Gly Ala Val Leu Leu Ser Ser Leu Ala Thr Thr Glu Val His 
        675                 680                 685             
Leu Ser Asp Lys Asp Lys Lys Arg Tyr Ser Lys Arg Glu Gln Phe Phe 
    690                 695                 700                 
Ala Arg Met Gly Ser Phe Val Ala Ile Gly Leu Ala Gln Ala Leu Ile 
705                 710                 715                 720 
Val Thr Leu Gly Asn Tyr Phe Gly Leu Gly Val Asp Val Arg Asp Pro 
                725                 730                 735     
Phe Tyr Ser Val Leu Phe Ala Leu Leu Ile Ser Ile Ala Phe Met Ile 
            740                 745                 750         
Met Val Tyr Val Leu Val Ala Leu Phe Gly Asn Val Gly Lys Gly Ile 
        755                 760                 765             
Ala Ile Ile Ile Leu Val Leu Ser Ile Ser Gly Gly Gly Gly Asn Tyr 
    770                 775                 780                 
Pro Ile Gln Val Ser Gly Lys Phe Phe Gln Ala Ile Asn Pro Tyr Leu 
785                 790                 795                 800 
Pro Phe Thr His Ala Val Asn Leu Leu Arg Glu Ser Ala Gly Gly Ile 
                805                 810                 815     
Tyr Trp Pro Asn Ala Trp Phe Ala Ile Ile Ile Leu Val Ala Val Ser 
            820                 825                 830         
Ile Val Phe Val Ala Ile Gly Ala Phe Leu Phe Pro His Phe Glu Asp 
        835                 840                 845             
Lys Thr Lys Lys Ile Ser Glu Ile Gly Ser Lys Ser His Phe Phe His 
    850                 855                 860                 



<210> 12
<211> 373
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 12
Val Lys Ser Ile Lys Asn Thr Trp Lys Leu Phe Ala Leu Asp Trp Lys 
1               5                   10                  15      
Arg Ile Phe Lys Asn Pro Val Ala Thr Phe Leu Ile Val Ala Leu Met 
            20                  25                  30          
Ile Ile Pro Ser Leu Tyr Ala Trp Phe Asn Ile Lys Ala Leu Trp Asp 
        35                  40                  45              
Pro Tyr Ala Asn Thr Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp 
    50                  55                  60                  
Lys Ser Ala Ser Phe Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val 
65                  70                  75                  80  
Leu Lys Asn Leu Lys Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp 
                85                  90                  95      
Ser Lys Ala Asp Leu Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala 
            100                 105                 110         
Gly Ile Tyr Leu Pro Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr 
        115                 120                 125             
Thr Gly Asp Ile Lys Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys 
    130                 135                 140                 
Ile Asn Ala Ile Ala Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu 
145                 150                 155                 160 
Gln Ser Gln Ile Ser Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu 
                165                 170                 175     
Leu Lys Thr Phe Asn Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val 
            180                 185                 190         
Ser Ile Gln Lys Val Lys Ser Val Ile Leu Ser Thr Asn Asp Asn Leu 
        195                 200                 205             
Gly Thr Ile Asp Lys Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys 
    210                 215                 220                 
Met Pro Glu Ile Lys Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr 
225                 230                 235                 240 
Tyr Leu Pro Glu Val Asp Ala Leu Gly Gln Lys Val Ile Lys Leu Asn 
                245                 250                 255     
Asp Lys Met Pro Glu Ile Asp Lys Ser Phe Ser Leu Val Leu Thr Leu 
            260                 265                 270         
Gln Glu Lys Ile Pro Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met 
        275                 280                 285             
Ile Asp Asp Asp Phe Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile 
    290                 295                 300                 
Gln Glu Ala Lys Gln Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser 
305                 310                 315                 320 
Met Pro Asp Ile Lys Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr 
                325                 330                 335     
Ile Thr Leu Asp Ala Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile 
            340                 345                 350         
Thr Asn Asn Thr Ser Ile Asn Ser Arg Val Leu Lys Lys Tyr Phe Ile 
        355                 360                 365             
Arg Tyr Phe Cys Tyr 
    370             

<210> 13
<211> 864
<212> PRT
<213> Lactococcus lactis subsp. lactis


<400> 13
Met Leu Gly Leu Ile Leu Lys Pro Cys Gly Thr Pro Tyr Ala Asn Thr 
1               5                   10                  15      
Ser Gln Leu Pro Ile Ala Val Tyr Ser Ala Asp Lys Ser Ala Ser Phe 
            20                  25                  30          
Gln Asp Lys Thr Ile Asn Ile Gly Asp Glu Val Leu Lys Asn Leu Lys 
        35                  40                  45              
Lys Asn His Gln Leu Gly Trp Lys Phe Val Asp Ser Lys Ala Asp Leu 
    50                  55                  60                  
Asp Lys Gly Val Lys Ser Gly Lys Tyr Tyr Ala Gly Ile Tyr Leu Pro 
65                  70                  75                  80  
Lys Asp Phe Ser Lys Asp Leu Leu Ser Phe Thr Thr Gly Asp Ile Lys 
                85                  90                  95      
Lys Pro Gln Ile Val Tyr Ser Ile Asn Glu Lys Ile Asn Ala Ile Ala 
            100                 105                 110         
Pro Lys Ile Thr Ser Lys Gly Ala Ser Ser Leu Gln Ser Gln Ile Ser 
        115                 120                 125             
Glu Glu Phe Ile Lys Thr Ala Ser Ser Thr Leu Leu Lys Thr Phe Asn 
    130                 135                 140                 
Thr Ile Gly Tyr Asp Ile Asp Lys Asn Met Val Ser Ile Gln Lys Val 
145                 150                 155                 160 
Lys Ser Val Ile Leu Ser Thr Asn Asp Asn Leu Gly Thr Ile Asp Lys 
                165                 170                 175     
Tyr Thr Gln Gln Val Val Asp Leu His Gly Lys Met Pro Glu Ile Lys 
            180                 185                 190         
Glu Lys Leu Ala Lys Ala Asn Glu Phe Ile Thr Tyr Leu Pro Glu Val 
        195                 200                 205             
Asp Ala Leu Gly Gln Lys Val Ile Lys Leu Asn Asp Lys Met Pro Glu 
    210                 215                 220                 
Ile Asp Lys Ser Phe Ser Leu Val Leu Thr Leu Gln Glu Lys Ile Pro 
225                 230                 235                 240 
Glu Ile Gln Asn Ala Gly Lys Gln Ile Ser Met Ile Asp Asp Asp Phe 
                245                 250                 255     
Ala Ser Val Glu Ser Thr Met Thr Gln Gly Ile Gln Glu Ala Lys Gln 
            260                 265                 270         
Gly Leu Gln Ile Ile Asn Gln Val Gln Lys Ser Met Pro Asp Ile Lys 
        275                 280                 285             
Lys Leu Gly Gln Asp Ala Asp Ser Leu Gly Thr Ile Thr Leu Asp Ala 
    290                 295                 300                 
Ala Lys Lys Met Gln Ser Ala Leu Pro Ser Ile Thr Asn Ser Val Gln 
305                 310                 315                 320 
Ile Thr Leu Gln Ser Ile Gln Glu Phe Ser Lys Asn Thr Ser Ser Val 
                325                 330                 335     
Ile Ser Val Ile Asp Gln Ala Ile Ala Asp Asn Gln Leu Thr Asp Asp 
            340                 345                 350         
Glu Lys Glu Gln Ile Asn Ser Leu Ile Thr Asn Phe Thr Asn Asn Ile 
        355                 360                 365             
Ala Lys Gln Arg Glu Ala Ile Gln Asn Ile Val Glu Tyr Met Lys Gln 
    370                 375                 380                 
Val Gln Glu Ser Asn Gly Asn His Asp Leu Asp Ser Thr Ile Glu Gln 
385                 390                 395                 400 
Leu Thr Asn Leu Asp Ser Leu Leu Ser Glu Leu Ser Thr Arg Met Ser 
                405                 410                 415     
His Leu Asn Asp Leu Val Gln Glu Gly Asp Val Thr Lys Ile Arg Ala 
            420                 425                 430         
Tyr Leu Ser Gln Ile Asn Asp Val Val Asn Asn Ile Ser Asp Leu Ile 
        435                 440                 445             
Asn Lys Ile Asp Val Ser Glu Ile Ser Ser Thr Ile Asn Lys Ala Leu 
    450                 455                 460                 
Thr Thr Leu Ile Asn Thr Ile Thr Asp Ala Lys Gly Leu Leu Asn Gln 
465                 470                 475                 480 
Ala Gln Gln Ile Asp Phe Asp Ala Leu Leu Asn Ser Thr Ser Gln Thr 
                485                 490                 495     
Val Ser Asn Ala Ile Thr Ile Leu Glu Lys Tyr Gln Gly Glu Met Pro 
            500                 505                 510         
Ala Ile Lys Gln Glu Ile His Asp Ala Asn Val Met Leu Asn Gly Asn 
        515                 520                 525             
Met Thr Thr Ile Val Asn Ala Ile Asn Glu Gly Ala Asn Leu Tyr Lys 
    530                 535                 540                 
Asn Glu Phe Pro Thr Leu Lys Ser Lys Leu Gly Thr Ala Ser Asp Phe 
545                 550                 555                 560 
Phe Lys Asn Asp Tyr Ala Gly Val Arg Lys Asp Leu Thr Asp Thr Leu 
                565                 570                 575     
Thr Met Ala Asn Asp Lys Met Pro Asp Val Glu Ser Ala Leu Asn Gln 
            580                 585                 590         
Ala Asn Asp Leu Ile Gln Asn Asp Trp Pro Glu Ile Lys Ser Gly Ile 
        595                 600                 605             
Gln Lys Ala Ala Ala Ala Ile Gln Lys Gly Glu Lys Glu Val Asp Leu 
    610                 615                 620                 
Gly Glu Ile Val Lys Leu Leu Lys Leu Asp Ala Thr Lys Glu Ser Asp 
625                 630                 635                 640 
Phe Leu Thr Gln Pro Val Glu Val Gln Glu Asn Gln Ile Tyr Pro Ile 
                645                 650                 655     
Ala Asn Asn Gly Ser Ala Ser Thr Pro Phe Tyr Thr Ala Leu Cys Leu 
            660                 665                 670         
Trp Val Gly Ala Val Leu Leu Ser Ser Leu Ala Thr Thr Glu Val His 
        675                 680                 685             
Leu Ser Asp Lys Asp Lys Lys Arg Tyr Ser Lys Arg Glu Gln Phe Phe 
    690                 695                 700                 
Ala Arg Met Gly Ser Phe Val Ala Ile Gly Leu Ala Gln Ala Leu Ile 
705                 710                 715                 720 
Val Thr Leu Gly Asn Tyr Phe Gly Leu Gly Val Asp Val Arg Asp Pro 
                725                 730                 735     
Phe Tyr Ser Val Leu Phe Ala Leu Leu Ile Ser Ile Ala Phe Met Ile 
            740                 745                 750         
Met Val Tyr Val Leu Val Ala Leu Phe Gly Asn Val Gly Lys Gly Ile 
        755                 760                 765             
Ala Ile Ile Ile Leu Val Leu Ser Ile Ser Gly Gly Gly Gly Asn Tyr 
    770                 775                 780                 
Pro Ile Gln Val Ser Gly Lys Phe Phe Gln Ala Ile Asn Pro Tyr Leu 
785                 790                 795                 800 
Pro Phe Thr His Ala Val Asn Leu Leu Arg Glu Ser Ala Gly Gly Ile 
                805                 810                 815     
Tyr Trp Pro Asn Ala Trp Phe Ala Ile Ile Ile Leu Val Ala Val Ser 
            820                 825                 830         
Ile Val Phe Val Ala Ile Gly Ala Phe Leu Phe Pro His Phe Glu Asp 
        835                 840                 845             
Lys Thr Lys Lys Ile Ser Glu Ile Gly Ser Lys Ser His Phe Phe His 
    850                 855                 860                 



