﻿                         序列表

<120>  一种抗TROP2抗体

<160>  40

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  8
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  1
Gly Tyr Thr Phe Thr Ser Phe Asp 
1               5               

<210>  2
<211>  7
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  2
Ile Phe Pro Gly Asp Gly Asn 
1               5           

<210>  3
<211>  11
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  3
Val Arg Gly Glu Ala Leu Tyr Tyr Phe Asp Tyr 
1               5                   10      

<210>  4
<211>  8
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  4
Gly Tyr Thr Phe Thr Asp His Val 
1               5               

<210>  5
<211>  8
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  5
Ile Tyr Pro Gly Ser Asp Asn Ser 
1               5               

<210>  6
<211>  18
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  6
Ala Arg Glu Gly Tyr Gly Tyr Gly Lys Asn Gly Val Gly Tyr Ala Met 
1               5                   10                  15      
Asp Tyr 
        

<210>  7
<211>  6
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  7
Gln Asp Ile Asn Lys Tyr 
1               5       

<210>  8
<211>  3
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  8
Ser Thr Ser 
1           

<210>  9
<211>  8
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  9
Leu Gln Tyr Asp Asp Leu Phe Thr 
1               5               

<210>  10
<211>  6
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  10
Gln Ser Val Ser Asn Asp 
1               5       

<210>  11
<211>  3
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  11
Tyr Ala Ser 
1           

<210>  12
<211>  9
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  12
Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   

<210>  13
<211>  137
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  13
Met Gly Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Ser Phe Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Trp Ile Phe Pro Gly Asp Gly Asn Thr Lys Ser Asn 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                85                  90                  95      
Thr Ala Tyr Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         
Tyr Phe Cys Val Arg Gly Glu Ala Leu Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             
Pro Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135         

<210>  14
<211>  126
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  14
Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      
Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Pro Ser Gln Asp 
        35                  40                  45              
Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  
Arg Leu Leu Ile His Ser Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Thr Ile Ser 
                85                  90                  95      
Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         
Asp Leu Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     

<210>  15
<211>  143
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  15
Met Glu Trp Arg Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly Val 
1               5                   10                  15      
His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro 
            20                  25                  30          
Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              
Asp His Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu 
    50                  55                  60                  
Trp Ile Gly Gln Ile Tyr Pro Gly Ser Asp Asn Ser Tyr Tyr Ser Glu 
65                  70                  75                  80  
Lys Leu Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr 
                85                  90                  95      
Ala Tyr Met Gln Leu Val Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         
Phe Cys Ala Arg Glu Gly Tyr Gly Tyr Gly Lys Asn Gly Val Gly Tyr 
        115                 120                 125             
Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140             

<210>  16
<211>  127
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  16
Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Gly Ala His Gly Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu 
            20                  25                  30          
Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Asn Asp Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  
Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      
Thr Ala Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         
Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         

<210>  17
<211>  137
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  17
Met Gly Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Ser Phe Asp Ile Asn Trp Val Arg Gln Ala Pro Glu Gln Arg Leu 
    50                  55                  60                  
Glu Trp Met Gly Trp Ile Phe Pro Gly Asp Gly Asn Thr Lys Tyr Ser 
65                  70                  75                  80  
Gln Lys Phe Gln Gly Arg Ala Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Val Arg Gly Glu Ala Leu Tyr Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135         

<210>  18
<211>  126
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  18
Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      
Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              
Ile Asn Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Ser Thr Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         
Asp Leu Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125     

<210>  19
<211>  143
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  19
Met Glu Trp Arg Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly Val 
1               5                   10                  15      
His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            20                  25                  30          
Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              
Asp His Val Ile Ser Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu 
    50                  55                  60                  
Trp Met Gly Gln Ile Tyr Pro Gly Ser Asp Asn Ser Tyr Tyr Ala Gln 
65                  70                  75                  80  
Lys Phe Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ile Asn Thr 
                85                  90                  95      
Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Glu Gly Tyr Gly Tyr Gly Lys Asn Gly Val Gly Tyr 
        115                 120                 125             
Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140             

<210>  20
<211>  127
<212>  PRT
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  20
Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Gly Ala His Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          
Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Asn Asp Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asp Tyr 
            100                 105                 110         
Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         

<210>  21
<211>  24
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  21
ggctacacct tcacaagctt tgat                                               24

<210>  22
<211>  21
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  22
atttttcctg gagatggtaa t                                                  21

<210>  23
<211>  33
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  23
gtaagagggg aggccctgta ttactttgac tac                                     33

<210>  24
<211>  24
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  24
ggatacacat tcactgacca tgtc                                               24

<210>  25
<211>  24
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  25
atttatcctg gaagtgataa tagt                                               24

<210>  26
<211>  54
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  26
gcaagagagg gctatggtta tggaaaaaac ggagttggct atgctatgga ctac              54

<210>  27
<211>  18
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  27
caagacatta ataagtat                                                      18

<210>  28
<211>  9
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  28
tccacatct                                                                 9

<210>  29
<211>  24
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  29
ctgcagtatg atgatctatt cacg                                               24

<210>  30
<211>  18
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  30
cagagtgtga gtaatgat                                                      18

<210>  31
<211>  9
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  31
tatgcatcc                                                                 9

<210>  32
<211>  27
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  32
cagcaggatt attcctctcc gtggacg                                            27

<210>  33
<211>  411
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  33
atgggatgga gctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccactcccag        60
gttcagctgc agcagtctgg agctgaactg gtaaagcctg gggcttcagt gaagttgtcc       120
tgcaaggctt ctggctacac cttcacaagc tttgatataa actgggtgag gcagaggcct       180
gaacagggac ttgagtggat tggatggatt tttcctggag atggtaatac taagtccaat       240
gagaaattta agggcaaggc cacactgact acagacaaat cctccagcac agcctacatg       300
cagctcagca ggctgacatc tgaggactct gctgtctatt tctgtgtaag aggggaggcc       360
ctgtattact ttgactactg gggcccaggc accactctca cagtctcctc a                411

<210>  34
<211>  379
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  34
atgagaccgt ctattcagtt cctggggctc ttgttgttct ggcttcatgg tgctcagtgt        60
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc       120
atcacttgca agccaagcca agacattaat aagtatatag cttggtacca acacaagcct       180
ggaaaaggtc ctaggctgct catacattcc acatctacat tacagccagg catcccatca       240
aggttcagtg gaagtgggtc tgggagagat tattccttca ccatcagcaa cctggaacct       300
gaagatattg caacttatta ttgtctgcag tatgatgatc tattcacgtt cggctcgggg       360
acaaagttgg aaataaaac                                                    379

<210>  35
<211>  429
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  35
atggaatgga ggatctttct cttcatcctg tcaggaactg caggtgtcca ctcccaggtt        60
cagctgcagc agtctggacc tgaggtggtg aagcctgggg cttcagtgaa gatgtcctgc       120
aaggcttctg gatacacatt cactgaccat gtcataagct gggtgaagca gagaactgga       180
cagggccttg agtggattgg acagatttat cctggaagtg ataatagtta ctacagtgag       240
aagttgaagg acaaggccac actgactgca gacaaatcct ccaacacagc ctacatgcag       300
ctcgtcagcc tgacatctga ggactctgcg gtctatttct gtgcaagaga gggctatggt       360
tatggaaaaa acggagttgg ctatgctatg gactactggg gtcaaggaac ctcagtcacc       420
gtctcctca                                                               429

<210>  36
<211>  382
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  36
atgaagtcac agacccaggt cttcgtattt ctactgctct gtgtgtctgg tgctcatggg        60
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       120
ataacctgca aggccagtca gagtgtgagt aatgatgtag tttggtacca acagaagcca       180
gggcagtctc ctaaactgct gatatactat gcatccaatc gctacactgg agtccctgat       240
cgcttcaccg gcagtggata tgggacggat ttcactttca ccatcagcac tgcgcaggct       300
gaagacctgg cagtttattt ctgtcagcag gattattcct ctccgtggac gttcggtggg       360
ggcaccaagc tggaaatcaa ac                                                382

<210>  37
<211>  412
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  37
atgggctggt cctgggtgtt cctgttcctg ctgagcgtga ccgccggcgt gcactcccag        60
gtgcagctgg tgcagtccgg cgccgaggtg aagaagcccg gcgcctccgt gaagctgagc       120
tgtaaggcct ccggctacac cttcacctcc ttcgacatta actgggtgcg gcaggccccc       180
gagcagcgcc tggagtggat gggctggatc ttccccggcg acggcaacac caagtactcc       240
cagaagttcc agggaagagc taccatcacc agagatacat ccgcttctac agcttacatg       300
gagctgtcta gcctgagatc tgaggataca gctgtgtatt actgtgtgag aggagaggct       360
ctgtactatt ttgattattg gggccagggc accctggtga cagtgtcttc tg               412

<210>  38
<211>  379
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  38
atgagacctt ctatccagtt tctgggcctg ctgctgtttt ggctgcatgg cgcccagtgc        60
gatatccaga tgacccagtc tccatctagc ctgtccgctt ctgtgggcga tagagtgacc       120
atcacatgca gagcttctca ggatatcaat aagtatctgg cttggtatca gcagaagcct       180
ggaaaggtgc ctaagctgct gatctactct acatctaccc tgcagtctgg agtgccttct       240
agattttctg gatctggctc tggcaccgat tttacactga caatctcttc tctgcagcct       300
gaggatgtgg ctacatatta ttgtctgcag tatgatgatc tgttcacctt tggccagggc       360
accaagctgg agatcaagc                                                    379

<210>  39
<211>  430
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  39
atggagtgga gaatctttct gtttatcctg tctggcacag ctggagtgca ttctcaggtg        60
cagctggtgc agtctggggc cgaggtgaaa aagccaggcg cttctgtgaa ggtgtcttgc       120
aaggcctccg gctacacctt caccgaccac gtgatctcct gggtgcgcca ggccaccggc       180
cagggcctgg agtggatggg ccagatctac cccggctccg acaactccta ctacgcccag       240
aagttccagg gcagggtgac tctgaccgcc gacaagtcca tcaacaccgc ctacatggag       300
ctgtcctccc tgaggtccga ggacaccgcc gtgtactact gcgccaggga gggctacggc       360
tacggcaaga acggcgtggg ctacgccatg gattattggg gccagggcac cctggtgaca       420
gtgtcttctg                                                              430

<210>  40
<211>  382
<212>  DNA
<213>  2 Ambystoma laterale x Ambystoma jeffersonianum

<400>  40
atgaagtctc agacccaggt gtttgtgttt ctgctgctgt gtgtgtctgg cgctcatggc        60
gatatcgtga tgacacagtc tcctgattct ctggccgtgt ctctgggcga aagagctaca       120
atcaactgta aggcttctca gtctgtgtct aatgatgtgg tgtggtacca gcagaagcct       180
gggcagcccc ccaagctgct gatctactac gcctccaaca ggtacaccgg cgtgcccgac       240
aggttctccg gctccggcta cggcaccgac ttcaccctga ccatctcctc cctgcaggcc       300
gaggacgtgg ccgtgtacta ctgccagcag gactactcct ccccctggac cttcggcggc       360
ggcaccaagg tggagatcaa gc                                                382

