                         SEQUENCE LISTING

<110>  Sun Pharmaceutical Industries Limited
 
<120>  LONG ACTING GLP-1/GIP DUAL AGONISTS

<130>  GLP-GIP

<150>  IN 202021026360
<151>  2020-06-22

<150>  IN 202121002838
<151>  2021-01-20

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  The acid group of the C terminal amino acid is a free carboxylic 
       acid  or is amidated as C-terminal primary amide

<220>
<221>  MISC_FEATURE
<223>  at least one of X3 and X5 is Lys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid), Ser(OMe) or D-Ser(OMe)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Tyr, Ser(OMe), D-Ser(OMe) or Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = Gln or Ala

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Gln or Lys; wherein, when X3 is Lys, the side chain amino 
       (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = Ala or Glu

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Leu, Ile or Glu

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = absent, Arg or Lys; wherein, when X5 is Lys, the side chain
       amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa = absent or Lys

<400>  1

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Xaa Lys 
1               5                   10                  15      


Ile Ala Xaa Xaa Xaa Phe Val Xaa Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45      


<210>  2
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  The acid group of the C terminal amino acid is a free carboxylic 
       acid  or is amidated as C-terminal primary amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Ser(OMe)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys, wherein the side chain amino (Epsilon amino) group of 
       Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Ile or Glu

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = absent or Arg

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa = absent or Lys

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa = absent or Lys

<400>  2

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Xaa Ala Phe Val Gln Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45      


<210>  3
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  The acid group of the C terminal amino acid is is a free 
       carboxylic acid  or is amidated as C-terminal primary amide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Ser(OMe) or Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa = Lys,  wherein the side chain amino (Epsilon amino) group of
       Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Ile or Glu

<400>  3

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Xaa Ala Phe Val Gln Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  the acid group of the C terminal amino acid is a free carboxylic 
       acid  or is amidated as C-terminal primary amide

<400>  4

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  5

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = D-Ser(OMe)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  6

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Ser (OMe)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  7

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = D-Tyr (OEt)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  8

Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = D-Ser (OMe)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  9

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Ser(OMe)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Ser at position 39 is amidated as a C-terminal primary amide

<400>  10

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<400>  11

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Asp Lys 
1               5                   10                  15      


Ile Ala Gln Lys Ala Phe Val Gln Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Arg 
        35                  40  


<210>  12
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Lys at position 40 is amidated as a C-terminal primary amide

<400>  12

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Ile Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  13
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib (2-Aminoisobutyric acid)

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ser (OMe)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Side chain amino (Epsilon amino) group of Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Lys at position 40 is amidated as a C-terminal primary amide

<400>  13

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Xaa Leu Glu Lys 
1               5                   10                  15      


Ile Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


