
                                SEQUENCE LISTING

<110> Jaiswal, Jyoti K.
      Defour, Aurelia
      Bittel, Daniel
      Chandra, Goutam
      Chandra, Sreetama Sen

<120> Use of Recombinant Human Acid
  Sphingomyelinase to Improve Skeletal Myofiber Repair
  

<130> 5410-P06791WO00

<150> 63/046,202          
<151> 2020-06-30  

<160> 3

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 631
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly
 1               5                  10                  15      
Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp
            20                  25                  30          
Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala
        35                  40                  45              
Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu
    50                  55                  60                  
Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu
65                  70                  75                  80  
Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly
                85                  90                  95      
Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala
            100                 105                 110         
Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala
        115                 120                 125             
Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met
    130                 135                 140                 
Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly
145                 150                 155                 160 
Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp
                165                 170                 175     
Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser
            180                 185                 190         
Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp
        195                 200                 205             
Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala
    210                 215                 220                 
Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg
225                 230                 235                 240 
Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu
                245                 250                 255     
Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe
            260                 265                 270         
Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His
        275                 280                 285             
Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu
    290                 295                 300                 
Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn
305                 310                 315                 320 
His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly
                325                 330                 335     
Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu
            340                 345                 350         
Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe
        355                 360                 365             
Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met
    370                 375                 380                 
Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp
385                 390                 395                 400 
Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu
                405                 410                 415     
Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His
            420                 425                 430         
Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr
        435                 440                 445             
Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu
    450                 455                 460                 
Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val
465                 470                 475                 480 
Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly
                485                 490                 495     
Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val
            500                 505                 510         
Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile
        515                 520                 525             
Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr
    530                 535                 540                 
Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr
545                 550                 555                 560 
Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr
                565                 570                 575     
His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu
            580                 585                 590         
Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu
        595                 600                 605             
Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu
    610                 615                 620                 
Trp Pro Arg Pro Leu Phe Cys
625                 630     


<210> 2
<211> 585
<212> PRT
<213> Homo sapiens

<400> 2
Leu Ala Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His
 1               5                  10                  15      
Pro Leu Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro
            20                  25                  30          
Arg Leu Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys
        35                  40                  45              
Lys Gly Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn
    50                  55                  60                  
Val Ala Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys
65                  70                  75                  80  
Ile Ala Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp
                85                  90                  95      
Asp Met Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala
            100                 105                 110         
Cys Gly Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser
        115                 120                 125             
Ser Trp Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro
    130                 135                 140                 
Pro Ser Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu
145                 150                 155                 160 
Thr Asp Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp
                165                 170                 175     
Cys Ala Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala
            180                 185                 190         
Ser Arg Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu
        195                 200                 205             
Pro Leu Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly
    210                 215                 220                 
Pro Phe Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val
225                 230                 235                 240 
Trp His Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr
                245                 250                 255     
Ala Leu Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val
            260                 265                 270         
Gly Asn His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile
        275                 280                 285             
Glu Gly Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala
    290                 295                 300                 
Trp Glu Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly
305                 310                 315                 320 
Gly Phe Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu
                325                 330                 335     
Asn Met Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser
            340                 345                 350         
Thr Asp Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala
        355                 360                 365             
Ala Glu Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro
    370                 375                 380                 
Gly His Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala
385                 390                 395                 400 
Arg Tyr Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val
                405                 410                 415     
Asp Glu Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu
            420                 425                 430         
Ala Val Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn
        435                 440                 445             
Pro Gly Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser
    450                 455                 460                 
His Val Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala
465                 470                 475                 480 
Asn Ile Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg
                485                 490                 495     
Glu Thr Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu
            500                 505                 510         
Val Tyr Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe
        515                 520                 525             
Leu Tyr His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys
    530                 535                 540                 
Arg Leu Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro
545                 550                 555                 560 
Ala Leu Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln
                565                 570                 575     
Ser Leu Trp Pro Arg Pro Leu Phe Cys
            580                 585 


<210> 3
<211> 2410
<212> DNA
<213> Homo sapiens

<400> 3
agtcagccga ctacagagaa gggtaatcgg gtgtccccgg cgccgcccgg ggccctgagg 60
gctggctagg gtccaggccg ggggggacgg gacagacgaa ccagccccgt gtaggaagcg 120
cgacaatgcc ccgctacgga gcgtcactcc gccagagctg ccccaggtcc ggccgggagc 180
agggacaaga cgggaccgcc ggagcccccg gactcctttg gatgggcctg gtgctggcgc 240
tggcgctggc gctggcgctg gcgctggctc tgtctgactc tcgggttctc tgggctccgg 300
cagaggctca ccctctttct ccccaaggcc atcctgccag gttacatcgc atagtgcccc 360
ggctccgaga tgtctttggg tgggggaacc tcacctgccc aatctgcaaa ggtctattca 420
ccgccatcaa cctcgggctg aagaaggaac ccaatgtggc tcgcgtgggc tccgtggcca 480
tcaagctgtg caatctgctg aagatagcac cacctgccgt gtgccaatcc attgtccacc 540
tctttgagga tgacatggtg gaggtgtgga gacgctcagt gctgagccca tctgaggcct 600
gtggcctgct cctgggctcc acctgtgggc actgggacat tttctcatct tggaacatct 660
ctttgcctac tgtgccgaag ccgcccccca aaccccctag ccccccagcc ccaggtgccc 720
ctgtcagccg catcctcttc ctcactgacc tgcactggga tcatgactac ctggagggca 780
cggaccctga ctgtgcagac ccactgtgct gccgccgggg ttctggcctg ccgcccgcat 840
cccggccagg tgccggatac tggggcgaat acagcaagtg tgacctgccc ctgaggaccc 900
tggagagcct gttgagtggg ctgggcccag ccggcccttt tgatatggtg tactggacag 960
gagacatccc cgcacatgat gtctggcacc agactcgtca ggaccaactg cgggccctga 1020
ccaccgtcac agcacttgtg aggaagttcc tggggccagt gccagtgtac cctgctgtgg 1080
gtaaccatga aagcacacct gtcaatagct tccctccccc cttcattgag ggcaaccact 1140
cctcccgctg gctctatgaa gcgatggcca aggcttggga gccctggctg cctgccgaag 1200
ccctgcgcac cctcagaatt ggggggttct atgctctttc cccatacccc ggtctccgcc 1260
tcatctctct caatatgaat ttttgttccc gtgagaactt ctggctcttg atcaactcca 1320
cggatcccgc aggacagctc cagtggctgg tgggggagct tcaggctgct gaggatcgag 1380
gagacaaagt gcatataatt ggccacattc ccccagggca ctgtctgaag agctggagct 1440
ggaattatta ccgaattgta gccaggtatg agaacaccct ggctgctcag ttctttggcc 1500
acactcatgt ggatgaattt gaggtcttct atgatgaaga gactctgagc cggccgctgg 1560
ctgtagcctt cctggcaccc agtgcaacta cctacatcgg ccttaatcct ggttaccgtg 1620
tgtaccaaat agatggaaac tactccggga gctctcacgt ggtcctggac catgagacct 1680
acatcctgaa tctgacccag gcaaacatac cgggagccat accgcactgg cagcttctct 1740
acagggctcg agaaacctat gggctgccca acacactgcc taccgcctgg cacaacctgg 1800
tatatcgcat gcggggcgac atgcaacttt tccagacctt ctggtttctc taccataagg 1860
gccacccacc ctcggagccc tgtggcacgc cctgccgtct ggctactctt tgtgcccagc 1920
tctctgcccg tgctgacagc cctgctctgt gccgccacct gatgccagat gggagcctcc 1980
cagaggccca gagcctgtgg ccaaggccac tgttttgcta gggccccagg gcccacattt 2040
gggaaagttc ttgatgtagg aaagggtgaa aaagcccaaa tgctgctgtg gttcaaccag 2100
gcaagatcat ccggtgaaag aaccagtccc tgggccccaa ggatgccggg gaaacaggac 2160
cttctccttt cctggagctg gtttagctgg atatgggagg gggtttggct gcctgtgccc 2220
aggagctaga ctgccttgag gctgctgtcc tttcacagcc atggagtaga ggcctaagtt 2280
gacactgccc tgggcagaca agacaggagc tgtcgcccca ggcctgtgct gcccagccag 2340
gaaccctgta ctgctgctgc gacctgatgc tgccagtctg ttaaaataaa gataagagac 2400
ttggactcca                                                        2410
