                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
 
<120>  DRUG REPURPOSING FOR TREATMENT OF VIRAL INFECTIONS

<130>  STAN-1766WO (S20-214)

<150>  63/047,078
<151>  2020-07-01

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMPRSS2 autoproteolysis motif

<400>  1

Arg Gln Ser Arg Ile Val 
1               5       


<210>  2
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu Leu Ser 
            20                  25                  30          


Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg Asn Arg 
        35                  40                  45              


Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln Ala Ser 
    50                  55                  60                  


Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His Gly Gly 
65                  70                  75                  80  


Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn Asp Ile 
                85                  90                  95      


Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr Ile Gln 
            100                 105                 110         


Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly Lys Ile 
        115                 120                 125             


Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln Gln Ala 
    130                 135                 140                 


Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp Val Cys 
145                 150                 155                 160 


Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met Phe Cys 
                165                 170                 175     


Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg Trp Arg 
        195                 200                 205             


Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala Gln Lys 
    210                 215                 220                 


Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile Phe Gln 
225                 230                 235                 240 


Ala Ile Lys 
            


<210>  3
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Val Gly Gly Glu Ser Ala Leu Pro Gly Ala Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu His Val Gln Asn Val His Val Cys Gly Gly Ser Ile Ile Thr 
            20                  25                  30          


Pro Glu Trp Ile Val Thr Ala Ala His Cys Val Glu Lys Pro Leu Asn 
        35                  40                  45              


Asn Pro Trp His Trp Thr Ala Phe Ala Gly Ile Leu Arg Gln Ser Phe 
    50                  55                  60                  


Met Phe Tyr Gly Ala Gly Tyr Gln Val Glu Lys Val Ile Ser His Pro 
65                  70                  75                  80  


Asn Tyr Asp Ser Lys Thr Lys Asn Asn Asp Ile Ala Leu Met Lys Leu 
                85                  90                  95      


Gln Lys Pro Leu Thr Phe Asn Asp Leu Val Lys Pro Val Cys Leu Pro 
            100                 105                 110         


Asn Pro Gly Met Met Leu Gln Pro Glu Gln Leu Cys Trp Ile Ser Gly 
        115                 120                 125             


Trp Gly Ala Thr Glu Glu Lys Gly Lys Thr Ser Glu Val Leu Asn Ala 
    130                 135                 140                 


Ala Lys Val Leu Leu Ile Glu Thr Gln Arg Cys Asn Ser Arg Tyr Val 
145                 150                 155                 160 


Tyr Asp Asn Leu Ile Thr Pro Ala Met Ile Cys Ala Gly Phe Leu Gln 
                165                 170                 175     


Gly Asn Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Thr 
            180                 185                 190         


Ser Lys Asn Asn Ile Trp Trp Leu Ile Gly Asp Thr Ser Trp Gly Ser 
        195                 200                 205             


Gly Cys Ala Lys Ala Tyr Arg Pro Gly Val Tyr Gly Asn Val Met Val 
    210                 215                 220                 


Phe Thr Asp Trp Ile Tyr Arg Gln Met Arg 
225                 230                 


<210>  4
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val 
1               5                   10                  15      


Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn 
            20                  25                  30          


Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn 
        35                  40                  45              


Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His 
    50                  55                  60                  


Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu 
                85                  90                  95      


His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro 
            100                 105                 110         


Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu 
        115                 120                 125             


Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu 
    130                 135                 140                 


Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln 
145                 150                 155                 160 


Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe 
                165                 170                 175     


Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser 
            180                 185                 190         


Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly 
        195                 200                 205             


Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val 
    210                 215                 220                 


Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg 
225                 230                 235                 240 


<210>  5
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Ile Asp Gly Lys Met Thr Arg Arg Gly Asp Ser Pro Trp Gln Val 
1               5                   10                  15      


Val Leu Leu Asp Ser Lys Lys Lys Leu Ala Cys Gly Ala Val Leu Ile 
            20                  25                  30          


His Pro Ser Trp Val Leu Thr Ala Ala His Cys Met Asp Glu Ser Lys 
        35                  40                  45              


Lys Leu Leu Val Arg Leu Gly Glu Tyr Asp Leu Arg Arg Trp Glu Lys 
    50                  55                  60                  


Trp Glu Leu Asp Leu Asp Ile Lys Glu Val Phe Val His Pro Asn Tyr 
65                  70                  75                  80  


Ser Lys Ser Thr Thr Asp Asn Asp Ile Ala Leu Leu His Leu Ala Gln 
                85                  90                  95      


Pro Ala Thr Leu Ser Gln Thr Ile Val Pro Ile Cys Leu Pro Asp Ser 
            100                 105                 110         


Gly Leu Ala Glu Arg Glu Leu Asn Gln Ala Gly Gln Glu Thr Leu Val 
        115                 120                 125             


Thr Gly Trp Gly Tyr His Ser Ser Arg Glu Lys Glu Ala Lys Arg Asn 
    130                 135                 140                 


Arg Thr Phe Val Leu Asn Phe Ile Lys Ile Pro Val Val Pro His Asn 
145                 150                 155                 160 


Glu Cys Ser Glu Val Met Ser Asn Met Val Ser Glu Asn Met Leu Cys 
                165                 170                 175     


Ala Gly Ile Leu Gly Asp Arg Gln Asp Ala Cys Glu Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Met Val Ala Ser Phe His Gly Thr Trp Phe Leu Val Gly Leu 
        195                 200                 205             


Val Ser Trp Gly Glu Gly Cys Gly Leu Leu His Asn Tyr Gly Val Tyr 
    210                 215                 220                 


Thr Lys Val Ser Arg Tyr Leu Asp Trp Ile His Gly His Ile Arg 
225                 230                 235                 


<210>  6
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
1               5                   10                  15      


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            20                  25                  30          


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        35                  40                  45              


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    50                  55                  60                  


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
65                  70                  75                  80  


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                85                  90                  95      


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            100                 105                 110         


Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys 
        115                 120                 125             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    130                 135                 140                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr 
145                 150                 155                 160 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                165                 170                 175     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            180                 185                 190         


Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        195                 200                 205             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    210                 215                 220                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly 
225                 230                 235 


<210>  7
<211>  243
<212>  PRT
<213>  Sus scrofa

<400>  7

Ile Met Gly Gly Ser Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln Ala 
1               5                   10                  15      


Lys Met Ile Ser His His Asn Leu Thr Ser Gly Ala Thr Leu Ile Asn 
            20                  25                  30          


Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Arg Leu Gly His Lys 
        35                  40                  45              


Asn Asp Thr Lys Ala Lys Asp Ile Ala Pro Thr Leu Arg Leu Tyr Val 
    50                  55                  60                  


Gly Lys Lys Gln Glu Val Glu Ile Glu Lys Val Ile Phe His Pro Asp 
65                  70                  75                  80  


Asn Ser Thr Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val Pro 
                85                  90                  95      


Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr Val 
            100                 105                 110         


Asn Val Gly Leu Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala Asn 
        115                 120                 125             


Leu Asn Phe Thr Glu His Leu Lys Tyr Val Met Leu Pro Val Ala Asp 
    130                 135                 140                 


Gln Glu Lys Cys Val Gln Tyr Tyr Glu Gly Ser Thr Val Pro Glu Lys 
145                 150                 155                 160 


Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu His 
                165                 170                 175     


Thr Phe Cys Ala Gly Leu Ser Lys Tyr Gln Glu Asp Thr Cys Tyr Gly 
            180                 185                 190         


Asp Ala Gly Ser Ala Phe Ala Val His Asp Lys Asp Asp Asp Thr Trp 
        195                 200                 205             


Tyr Ala Ala Gly Ile Leu Ser Phe Asp Lys Ser Cys Arg Thr Ala Glu 
    210                 215                 220                 


Tyr Gly Val Tyr Val Arg Val Thr Ser Ile Leu Asp Trp Ile Gln Thr 
225                 230                 235                 240 


Thr Ile Ala 
            


<210>  8
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Val Gly Gly Glu Ser Ala Leu Pro Gly Ala Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu His Val Gln Asn Val His Val Cys Gly Gly Ser Ile Ile Thr 
            20                  25                  30          


Pro Glu Trp Ile Val Thr Ala Ala His Cys Val Glu Lys Pro Leu Asn 
        35                  40                  45              


Asn Pro Trp His Trp Thr Ala Phe Ala Gly Ile Leu Arg Gln Ser Phe 
    50                  55                  60                  


Met Phe Tyr Gly Ala Gly Tyr Gln Val Glu Lys Val Ile Ser His Pro 
65                  70                  75                  80  


Asn Tyr Asp Ser Lys Thr Lys Asn Asn Asp Ile Ala Leu Met Lys Leu 
                85                  90                  95      


Gln Lys Pro Leu Thr Phe Asn Asp Leu Val Lys Pro Val Cys Leu Pro 
            100                 105                 110         


Asn Pro Gly Met Met Leu Gln Pro Glu Gln Leu Cys Trp Ile Ser Gly 
        115                 120                 125             


Trp Gly Ala Thr Glu Glu Lys Gly Lys Thr Ser Glu Val Leu Asn Ala 
    130                 135                 140                 


Ala Lys Val Leu Leu Ile Glu Thr Gln Arg Cys Asn Ser Arg Tyr Val 
145                 150                 155                 160 


Tyr Asp Asn Leu Ile Thr Pro Ala Met Ile Cys Ala Gly Phe Leu Gln 
                165                 170                 175     


Gly Asn Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Thr 
            180                 185                 190         


Ser Lys Asn Asn Ile Trp Trp Leu Ile Gly Asp Thr Ser Trp Gly Ser 
        195                 200                 205             


Gly Cys Ala Lys Ala Tyr Arg Pro Gly Val Tyr Gly Asn Val Met Val 
    210                 215                 220                 


Phe Thr Asp Trp Ile Tyr Arg Gln Met Arg Ala Asp Gly 
225                 230                 235         


<210>  9
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu Leu Ser 
            20                  25                  30          


Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg Asn Arg 
        35                  40                  45              


Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln Ala Ser 
    50                  55                  60                  


Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His Gly Gly 
65                  70                  75                  80  


Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn Asp Ile 
                85                  90                  95      


Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr Ile Gln 
            100                 105                 110         


Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly Lys Ile 
        115                 120                 125             


Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln Gln Ala 
    130                 135                 140                 


Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp Val Cys 
145                 150                 155                 160 


Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met Phe Cys 
                165                 170                 175     


Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp Ser Gly 
            180                 185                 190         


Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg Trp Arg 
        195                 200                 205             


Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala Gln Lys 
    210                 215                 220                 


Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile Phe Gln 
225                 230                 235                 240 


Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln Leu 
                245                 250                 255 


<210>  10
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Val Gly Gly Tyr Thr Cys Glu Glu Asn Ser Leu Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ser Gly Ser His Phe Cys Gly Gly Ser Leu Ile Ser Glu 
            20                  25                  30          


Gln Trp Val Val Ser Ala Ala His Cys Tyr Lys Thr Arg Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu His Asn Ile Lys Val Leu Glu Gly Asn Glu Gln Phe 
    50                  55                  60                  


Ile Asn Ala Val Lys Ile Ile Arg His Pro Lys Tyr Asn Arg Asp Thr 
65                  70                  75                  80  


Leu Asp Asn Asp Ile Met Leu Ile Lys Leu Ser Ser Pro Ala Val Ile 
                85                  90                  95      


Asn Ala Arg Val Ser Thr Ile Ser Leu Pro Thr Ala Pro Pro Ala Ala 
            100                 105                 110         


Gly Thr Glu Cys Leu Ile Ser Gly Trp Gly Asn Thr Leu Ser Phe Gly 
        115                 120                 125             


Ala Asp Tyr Pro Asp Glu Leu Lys Cys Leu Asp Ala Pro Val Leu Thr 
    130                 135                 140                 


Gln Ala Glu Cys Lys Ala Ser Tyr Pro Gly Lys Ile Thr Asn Ser Met 
145                 150                 155                 160 


Phe Cys Val Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Arg Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Val Cys Asn Gly Gln Leu Gln Gly Val Val Ser 
            180                 185                 190         


Trp Gly His Gly Cys Ala Trp Lys Asn Arg Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Tyr Asn Tyr Val Asp Trp Ile Lys Asp Thr Ile Ala Ala Asn Ser 
    210                 215                 220                 


<210>  11
<211>  223
<212>  PRT
<213>  Sus scrofa

<400>  11

Ile Val Gly Gly Tyr Thr Cys Ala Ala Asn Ser Ile Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ser Gly Ser His Phe Cys Gly Gly Ser Leu Ile Asn Ser 
            20                  25                  30          


Gln Trp Val Val Ser Ala Ala His Cys Tyr Lys Ser Arg Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu His Asn Ile Asp Val Leu Glu Gly Asn Glu Gln Phe 
    50                  55                  60                  


Ile Asn Ala Ala Lys Ile Ile Thr His Pro Asn Phe Asn Gly Asn Thr 
65                  70                  75                  80  


Leu Asp Asn Asp Ile Met Leu Ile Lys Leu Ser Ser Pro Ala Thr Leu 
                85                  90                  95      


Asn Ser Arg Val Ala Thr Val Ser Leu Pro Arg Ser Cys Ala Ala Ala 
            100                 105                 110         


Gly Thr Glu Cys Leu Ile Ser Gly Trp Gly Asn Thr Lys Ser Ser Gly 
        115                 120                 125             


Ser Ser Tyr Pro Ser Leu Leu Gln Cys Leu Lys Ala Pro Val Leu Ser 
    130                 135                 140                 


Asp Ser Ser Cys Lys Ser Ser Tyr Pro Gly Gln Ile Thr Gly Asn Met 
145                 150                 155                 160 


Ile Cys Val Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Val Cys Asn Gly Gln Leu Gln Gly Ile Val Ser 
            180                 185                 190         


Trp Gly Tyr Gly Cys Ala Gln Lys Asn Lys Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Cys Asn Tyr Val Asn Trp Ile Gln Gln Thr Ile Ala Ala Asn 
    210                 215                 220             


