                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

<120> PERSISTENT MEMORY T-CELL RESPONSES TO CANCER AND 
      INFECTIOUS-DISEASE ANTIGENS BY MANIPULATION OF AMINO 
      ACID-CATABOLISM PATHWAYS

<130> 070772-1256947-229810PC

<140> PCT/US2021/040132
<141> 2021-07-01

<150> 63/047,737
<151> 2020-07-02

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 4801
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg gatcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaggaatt agctggcgcg     1200

ccttcccgcc accatgggcg tgagaaactc cgtcttgtca gggaagaaag cagatgaatt     1260

agaaaaaatt aggctacgac ccaacggaaa gaaaaagtac atgttgaagc atgtagtatg     1320

ggcagcaaat gaattagata gatttggatt agcagaaagc ctgttggaga acaaagaagg     1380

atgtcaaaaa atactttcgg tcttagctcc attagtgcca acaggctcag aaaatttaaa     1440

aagcctttat aatactgtct gcgtcatctg gtgcattcac gcagaagaga aagtgaaaca     1500

cactgaggaa gcaaaacaga tagtgcagag acacctagtg gtggaaacag gaaccaccga     1560

aaccatgccg aagacctctc gaccaacagc accatctagc ggcagaggag gaaactaccc     1620

agtacagcag atcggtggca actacgtcca cctgccactg tccccgagaa ccctgaacgc     1680

ttgggtcaag ctgatcgagg agaagaagtt cggagcagaa gtagtgccag gattccaggc     1740

actgtcagaa ggttgcaccc cctacgacat caaccagatg ctgaactgcg ttggagacca     1800

tcaggcggct atgcagatca tccgtgacat catcaacgag gaggctgcag attgggactt     1860

gcagcaccca caaccagctc cacaacaagg acaacttagg gagccgtcag gatcagacat     1920

cgcaggaacc acctcctcag ttgacgaaca gatccagtgg atgtaccgtc agcagaaccc     1980

gatcccagta ggcaacatct accgtcgatg gatccagctg ggtctgcaga aatgcgtccg     2040

tatgtacaac ccgaccaaca ttctagatgt aaaacaaggg ccaaaagagc catttcagag     2100

ctatgtagac aggttctaca aaagtttaag agcagaacag acagatgcag cagtaaagaa     2160

ttggatgact caaacactgc tgattcaaaa tgctaaccca gattgcaagc tagtgctgaa     2220

ggggctgggt gtgaatccca ccctagaaga aatgctgacg gcttgtcaag gagtaggggg     2280

gccgggacag aaggctagat taatggcaga agccctgaaa gaggccctcg caccagtgcc     2340

aatccctttt gcagcagccc aacagagggg accaagaaag ccaattaagt gttggaattg     2400

tgggaaagag ggacactctg caaggcaatg cagagcccca agaagacagg gatgctggaa     2460

atgtggaaaa atggaccatg ttatggccaa atgcccagac agacaggcgg gttttttagg     2520

ccttggtcca tggggaaaga agccccgcaa tttccccatg gctcaagtgc atcaggggct     2580

gatgccaact gctcccccag aggacccagc tgtggatctg ctaaagaact acatgcagtt     2640

gggcaagcag cagagagaaa agcagagaga aagcagagag aagccttaca aggaggtgac     2700

agaggatttg ctgcacctca attctctctt tggaggagac cagtagtagc ctgcaggccc     2760

ctctccctcc ccccccccta acgttactgg ccgaagccgc ttggaataag gccggtgtgc     2820

gtttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga gggcccggaa     2880

acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg ccaaaggaat     2940

gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt gaagacaaac     3000

aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca ggtgcctctg     3060

cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc agtgccacgt     3120

tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg     3180

gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc ctcggtgcac     3240

atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga accacgggga     3300

cgtggttttc ctttgaaaaa cacgatgata aagccaccat ggcacatgct atggaaaact     3360

cctggacaat cagtgaagag taccatattg atgaagaagt gggcttcgct ctgccaaatc     3420

cacaggaaaa tctacctgat ttttataatg actggatgtt cattgccaaa catctgcctg     3480

atctcataga gtctggccaa cttcgagaaa gagttgagaa gttagacatg ctcagcattg     3540

atcatctcac agaccacaag tcacagcgcc ttgcacatct agttctggga tgcatcacca     3600

tggcatatgt gtgggataaa ggtcatggag acgtccgtaa ggtcttgcca agaaatattg     3660

ctgttcctta ctgccaactc tccaagaaac tgggcctgcc tcctattctg gtttatgcag     3720

actgtgtctt ggcaaactgg aagaaaaagg atcctaataa gcccctgact tatgagaaca     3780

tggacgtttt gttctccttt cgtgatggag actgcagtaa aggattcttc ctggtttctc     3840

tattggtgga aatagcagct gcttctgcta tcaaagaaat tcctactgta ttcagggcaa     3900

tgcaattgcg agaacgggac actctgctaa aggcactgtt ggaaatagct tcttgcctgg     3960

agaaagcccg tcaagtgttt cagcaaatgc acgatcacgt aaacccaaat gcattttaca     4020

gtgttcttcg catatatttg gctggctgga aaggcaaccc ccagctatca gacggtctgg     4080

tgtatgaggg gttctgggaa ggcccaaaga agtttgcagg gggcagtgca gcacaaagca     4140

gcatctttca gtgctttgac gtcctgctgg gcatccaaca gaatgctggt ggaggacatg     4200

ctgctcagtt cctccaggac atgagaacat atatgccacc agctcacagg aacttcctgt     4260

actcattaga gtcaagtccc tcagtccgtg agtttgtcct ttcaaaaggt gatgctggcc     4320

tgcgggaagc ttatgatgcc tgtgtgaaag ctctggtctc cctgaggagc taccatctgc     4380

aaatcgtgac taagtacgtc ctgattcctg caagccagca gccaaaggaa aacaagacct     4440

ctgaagaccc ttcaaaactg gatgccaaag gaactggagg cactgattta atggaattcc     4500

taaagactgt gagaagtaca accgagaaat accgtttgaa ggaaggttaa gacctgcagg     4560

acgccacagc tctgatcata atcagccata ccacatttgt agaggtttta cttgctttaa     4620

aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta     4680

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     4740

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctg     4800

c                                                                     4801


<210> 2
<211> 419
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 2
Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210> 3
<211> 4526
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaggaatt agctggcgcg     1200

ccttcccgcc accatgagcg ataacggccc ccagaatcag aggaatgcac ctaggataac     1260

atttggaggt ccgtcagaca gcactggctc caaccagaat ggcgagcggt ctggcgcgcg     1320

gtctaagcaa aggagaccac aaggtctccc gaataacacg gcctcctggt ttacagcgct     1380

cacccagcac ggtaaagagg acctgaagtt ccctaggggg caaggtgtac cgattaatac     1440

caacagctcc cccgatgacc agattggtta ttatagaaga gctacaagac gcatacgggg     1500

tggagatggg aagatgaagg acctctcccc tcggtggtat ttttattatc tgggcaccgg     1560

accggaagcc gggctcccct acggcgccaa taaggacggt ataatatggg tcgccactga     1620

gggtgccctc aataccccga aggaccacat tggcactcga aacccggcaa acaacgcagc     1680

tattgtcctg caactcccac agggtaccac gctcccgaaa ggtttttatg ccgaagggtc     1740

tcgcgggggt tcacaggcta gcagtcgaag ctcatctcgg agccgaaata gctcaaggaa     1800

ttcaacaccc ggaagctcca gaggcacaag ccctgcgcgg atggcaggga acggaggcga     1860

tgctgccctg gccctccttc tcttggatag acttaatcag ctggaatcca aaatgtcagg     1920

aaagggccag caacaacaag gtcagacagt gaccaaaaaa tccgccgcag aggccagtaa     1980

gaaacctaga cagaagcgaa ctgctacaaa ggcctataat gtaactcagg cgttcggacg     2040

gcgaggccct gaacaaaccc agggcaattt cggtgaccaa gaactcataa gacagggaac     2100

tgactacaaa cattggcccc agattgcaca atttgcccca tccgcctcag ccttcttcgg     2160

aatgtctcgc atcgggatgg aggtaacacc gagcgggacc tggctcacat acacaggtgc     2220

gataaagctc gatgacaaag atcccaattt taaagaccaa gtgatacttc ttaataagca     2280

catagacgcc tataaaacct tcccgcccac tgagccaaag aaagacaaga aaaaaaaagc     2340

ggacgagaca caagcccttc cgcaaagaca gaaaaaacag caaacggtta cattgcttcc     2400

tgcggcagac ctggatgatt tttccaaaca gcttcagcaa tctatgtcta gcgcagatag     2460

tacccaggcg taatagcctg caggcccctc tccctccccc ccccctaacg ttactggccg     2520

aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc     2580

gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga gcattcctag     2640

gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga aggaagcagt     2700

tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca ggcagcggaa     2760

ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag atacacctgc     2820

aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa gagtcaaatg     2880

gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac cccattgtat     2940

gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa     3000

acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac gatgataaag     3060

ccaccatggc acatgctatg gaaaactcct ggacaatcag tgaagagtac catattgatg     3120

aagaagtggg cttcgctctg ccaaatccac aggaaaatct acctgatttt tataatgact     3180

ggatgttcat tgccaaacat ctgcctgatc tcatagagtc tggccaactt cgagaaagag     3240

ttgagaagtt agacatgctc agcattgatc atctcacaga ccacaagtca cagcgccttg     3300

cacatctagt tctgggatgc atcaccatgg catatgtgtg ggataaaggt catggagacg     3360

tccgtaaggt cttgccaaga aatattgctg ttccttactg ccaactctcc aagaaactgg     3420

gcctgcctcc tattctggtt tatgcagact gtgtcttggc aaactggaag aaaaaggatc     3480

ctaataagcc cctgacttat gagaacatgg acgttttgtt ctcctttcgt gatggagact     3540

gcagtaaagg attcttcctg gtttctctat tggtggaaat agcagctgct tctgctatca     3600

aagaaattcc tactgtattc agggcaatgc aattgcgaga acgggacact ctgctaaagg     3660

cactgttgga aatagcttct tgcctggaga aagcccgtca agtgtttcag caaatgcacg     3720

atcacgtaaa cccaaatgca ttttacagtg ttcttcgcat atatttggct ggctggaaag     3780

gcaaccccca gctatcagac ggtctggtgt atgaggggtt ctgggaaggc ccaaagaagt     3840

ttgcaggggg cagtgcagca caaagcagca tctttcagtg ctttgacgtc ctgctgggca     3900

tccaacagaa tgctggtgga ggacatgctg ctcagttcct ccaggacatg agaacatata     3960

tgccaccagc tcacaggaac ttcctgtact cattagagtc aagtccctca gtccgtgagt     4020

ttgtcctttc aaaaggtgat gctggcctgc gggaagctta tgatgcctgt gtgaaagctc     4080

tggtctccct gaggagctac catctgcaaa tcgtgactaa gtacgtcctg attcctgcaa     4140

gccagcagcc aaaggaaaac aagacctctg aagacccttc aaaactggat gccaaaggaa     4200

ctggaggcac tgatttaatg gaattcctaa agactgtgag aagtacaacc gagaaatacc     4260

gtttgaagga aggttaagac ctgcaggacg ccacagctct gatcataatc agccatacca     4320

catttgtaga ggttttactt gctttaaaaa acctcccaca cctccccctg aacctgaaac     4380

ataaaatgaa tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat     4440

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     4500

gtttgtccaa actcatcaat gtatct                                          4526


<210> 4
<211> 690
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 4
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln 
    690 


<210> 5
<211> 5339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtgaggaatt agctggcgcg     1200

ccttcccgcc accatgtttg tgtttctggt attgctgcca ttggtctcca gccaatgtgt     1260

taatctcacg accaggaccc aattgcctcc cgcgtatact aactctttca cgaggggagt     1320

ctactatcct gacaaagtat ttaggtcttc agtgctgcat agtacacaag acctgttcct     1380

tccgtttttc agcaacgtga cttggttcca cgctatacac gtctcaggga cgaatggaac     1440

aaagcgcttc gataatccgg ttttgccatt taatgatggt gtctatttcg catccacaga     1500

aaagtccaac attatcaggg ggtggatctt tggtacgacg ctggatagca aaacacagtc     1560

cctccttatc gtcaacaatg ccacgaatgt ggtgattaag gtttgcgaat ttcaattttg     1620

taacgaccct tttcttggcg tatattatca taaaaacaac aagtcctgga tggaaagcga     1680

attccgcgta tacagttccg caaacaactg tacatttgaa tatgtgagcc aaccttttct     1740

gatggacctg gagggcaaac agggcaactt taaaaatttg agagagttcg tcttcaaaaa     1800

tattgatgga tatttcaaga tttatagtaa gcatacgccc ataaatcttg tccgggatct     1860

gccgcagggt tttagcgctc tcgaaccctt ggtagacctc ccgattggta taaacatcac     1920

caggtttcag acccttcttg cgttgcaccg cagctatctc acgccaggcg atagtagttc     1980

aggttggact gccggagcag cagcctacta cgtaggctac cttcaaccta gaacgtttct     2040

gttgaaatat aatgaaaatg gtacaatcac agacgcggtc gactgcgcac tggacccgct     2100

gagcgaaacc aaatgtacgc tcaagtcctt caccgtagag aaaggcatct accagacttc     2160

taatttccga gtgcagccga cggagtcaat cgtgagattc cctaacataa ctaatttgtg     2220

tccatttggc gaagtgttca atgcaaccag attcgcctcc gtctatgcgt ggaatcgaaa     2280

aagaatttca aactgcgtag cggattattc tgtcttgtac aatagtgcct cctttagtac     2340

gttcaagtgt tatggggtgt caccaacgaa gttgaatgat ctttgtttca cgaatgttta     2400

cgctgattca tttgtaatac gcggagacga agttagacaa atcgcaccag ggcagacagg     2460

caagatcgcg gattataatt ataagctgcc agacgacttc actgggtgcg ttatcgcatg     2520

gaactccaac aacttggata gtaaagtggg cgggaattac aactacctgt atagactttt     2580

ccgaaagtcc aatttgaagc cattcgaaag ggacatttct actgaaatat atcaagcggg     2640

atcaacacct tgcaacggag tggaagggtt caactgctac tttccgctgc aatcttatgg     2700

gtttcaaccg actaatggag tcgggtatca gccttacaga gttgttgttc tttcctttga     2760

gctgttgcat gccccggcaa ccgtatgtgg gcccaagaaa tctacaaacc tcgttaagaa     2820

taaatgcgtg aatttcaact tcaatggtct caccgggacg ggggtcctga ccgaaagtaa     2880

caagaaattt ctgccctttc agcaattcgg aagagacatc gcggacacta cagacgccgt     2940

tcgggacccg cagactctcg aaattcttga catcacgccg tgttcattcg gaggcgtttc     3000

cgtgattaca ccaggaacga ataccagcaa tcaagtggca gtgttgtatc aagatgttaa     3060

ttgcactgaa gtgcctgtcg ctatccacgc ggaccagctc acgcctacgt ggagggtgta     3120

ttcaacagga agcaacgtgt tccaaacacg agcgggttgt cttatagggg cggagcacgt     3180

gaacaatagt tacgaatgtg atataccgat aggggctggg atatgtgcgt cttatcaaac     3240

acagacgaat agccccaggc gcgctcgaag tgtggcaagc caatagtagc ctgcaggccc     3300

ctctccctcc ccccccccta acgttactgg ccgaagccgc ttggaataag gccggtgtgc     3360

gtttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga gggcccggaa     3420

acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg ccaaaggaat     3480

gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt gaagacaaac     3540

aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca ggtgcctctg     3600

cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc agtgccacgt     3660

tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg     3720

gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc ctcggtgcac     3780

atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga accacgggga     3840

cgtggttttc ctttgaaaaa cacgatgata aagccaccat ggcacatgct atggaaaact     3900

cctggacaat cagtgaagag taccatattg atgaagaagt gggcttcgct ctgccaaatc     3960

cacaggaaaa tctacctgat ttttataatg actggatgtt cattgccaaa catctgcctg     4020

atctcataga gtctggccaa cttcgagaaa gagttgagaa gttagacatg ctcagcattg     4080

atcatctcac agaccacaag tcacagcgcc ttgcacatct agttctggga tgcatcacca     4140

tggcatatgt gtgggataaa ggtcatggag acgtccgtaa ggtcttgcca agaaatattg     4200

ctgttcctta ctgccaactc tccaagaaac tgggcctgcc tcctattctg gtttatgcag     4260

actgtgtctt ggcaaactgg aagaaaaagg atcctaataa gcccctgact tatgagaaca     4320

tggacgtttt gttctccttt cgtgatggag actgcagtaa aggattcttc ctggtttctc     4380

tattggtgga aatagcagct gcttctgcta tcaaagaaat tcctactgta ttcagggcaa     4440

tgcaattgcg agaacgggac actctgctaa aggcactgtt ggaaatagct tcttgcctgg     4500

agaaagcccg tcaagtgttt cagcaaatgc acgatcacgt aaacccaaat gcattttaca     4560

gtgttcttcg catatatttg gctggctgga aaggcaaccc ccagctatca gacggtctgg     4620

tgtatgaggg gttctgggaa ggcccaaaga agtttgcagg gggcagtgca gcacaaagca     4680

gcatctttca gtgctttgac gtcctgctgg gcatccaaca gaatgctggt ggaggacatg     4740

ctgctcagtt cctccaggac atgagaacat atatgccacc agctcacagg aacttcctgt     4800

actcattaga gtcaagtccc tcagtccgtg agtttgtcct ttcaaaaggt gatgctggcc     4860

tgcgggaagc ttatgatgcc tgtgtgaaag ctctggtctc cctgaggagc taccatctgc     4920

aaatcgtgac taagtacgtc ctgattcctg caagccagca gccaaaggaa aacaagacct     4980

ctgaagaccc ttcaaaactg gatgccaaag gaactggagg cactgattta atggaattcc     5040

taaagactgt gagaagtaca accgagaaat accgtttgaa ggaaggttaa gacctgcagg     5100

acgccacagc tctgatcata atcagccata ccacatttgt agaggtttta cttgctttaa     5160

aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta     5220

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     5280

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatct      5339


<210> 6
<211> 2070
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgtttgtgt ttctggtatt gctgccattg gtctccagcc aatgtgttaa tctcacgacc       60

aggacccaat tgcctcccgc gtatactaac tctttcacga ggggagtcta ctatcctgac      120

aaagtattta ggtcttcagt gctgcatagt acacaagacc tgttccttcc gtttttcagc      180

aacgtgactt ggttccacgc tatacacgtc tcagggacga atggaacaaa gcgcttcgat      240

aatccggttt tgccatttaa tgatggtgtc tatttcgcat ccacagaaaa gtccaacatt      300

atcagggggt ggatctttgg tacgacgctg gatagcaaaa cacagtccct ccttatcgtc      360

aacaatgcca cgaatgtggt gattaaggtt tgcgaatttc aattttgtaa cgaccctttt      420

cttggcgtat attatcataa aaacaacaag tcctggatgg aaagcgaatt ccgcgtatac      480

agttccgcaa acaactgtac atttgaatat gtgagccaac cttttctgat ggacctggag      540

ggcaaacagg gcaactttaa aaatttgaga gagttcgtct tcaaaaatat tgatggatat      600

ttcaagattt atagtaagca tacgcccata aatcttgtcc gggatctgcc gcagggtttt      660

agcgctctcg aacccttggt agacctcccg attggtataa acatcaccag gtttcagacc      720

cttcttgcgt tgcaccgcag ctatctcacg ccaggcgata gtagttcagg ttggactgcc      780

ggagcagcag cctactacgt aggctacctt caacctagaa cgtttctgtt gaaatataat      840

gaaaatggta caatcacaga cgcggtcgac tgcgcactgg acccgctgag cgaaaccaaa      900

tgtacgctca agtccttcac cgtagagaaa ggcatctacc agacttctaa tttccgagtg      960

cagccgacgg agtcaatcgt gagattccct aacataacta atttgtgtcc atttggcgaa     1020

gtgttcaatg caaccagatt cgcctccgtc tatgcgtgga atcgaaaaag aatttcaaac     1080

tgcgtagcgg attattctgt cttgtacaat agtgcctcct ttagtacgtt caagtgttat     1140

ggggtgtcac caacgaagtt gaatgatctt tgtttcacga atgtttacgc tgattcattt     1200

gtaatacgcg gagacgaagt tagacaaatc gcaccagggc agacaggcaa gatcgcggat     1260

tataattata agctgccaga cgacttcact gggtgcgtta tcgcatggaa ctccaacaac     1320

ttggatagta aagtgggcgg gaattacaac tacctgtata gacttttccg aaagtccaat     1380

ttgaagccat tcgaaaggga catttctact gaaatatatc aagcgggatc aacaccttgc     1440

aacggagtgg aagggttcaa ctgctacttt ccgctgcaat cttatgggtt tcaaccgact     1500

aatggagtcg ggtatcagcc ttacagagtt gttgttcttt cctttgagct gttgcatgcc     1560

ccggcaaccg tatgtgggcc caagaaatct acaaacctcg ttaagaataa atgcgtgaat     1620

ttcaacttca atggtctcac cgggacgggg gtcctgaccg aaagtaacaa gaaatttctg     1680

ccctttcagc aattcggaag agacatcgcg gacactacag acgccgttcg ggacccgcag     1740

actctcgaaa ttcttgacat cacgccgtgt tcattcggag gcgtttccgt gattacacca     1800

ggaacgaata ccagcaatca agtggcagtg ttgtatcaag atgttaattg cactgaagtg     1860

cctgtcgcta tccacgcgga ccagctcacg cctacgtgga gggtgtattc aacaggaagc     1920

aacgtgttcc aaacacgagc gggttgtctt ataggggcgg agcacgtgaa caatagttac     1980

gaatgtgata taccgatagg ggctgggata tgtgcgtctt atcaaacaca gacgaatagc     2040

cccaggcgcg ctcgaagtgt ggcaagccaa                                      2070


