                         SEQUENCE LISTING

<110>  תҽѧоԺ
 
<120>  FAP쳣ؼԼСɶ洢

<130>  20D-1616-WOP2

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  760
<212>  PRT
<213>  

<400>  1

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  2
<211>  734
<212>  PRT
<213>  ˹

<400>  2

Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 


<210>  3
<211>  77
<212>  PRT
<213>  ˹

<400>  3

Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr 
1               5                   10                  15      


Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His 
            20                  25                  30          


Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu 
        35                  40                  45              


Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys 
    50                  55                  60                  


Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
65                  70                  75          


<210>  4
<211>  17
<212>  PRT
<213>  ˹

<400>  4

Phe Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala 
1               5                   10                  15      


Asp 
    


<210>  5
<211>  100
<212>  PRT
<213>  ˹

<400>  5

Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val 
1               5                   10                  15      


Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn 
            20                  25                  30          


Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val 
        35                  40                  45              


Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val 
    50                  55                  60                  


Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val 
65                  70                  75                  80  


Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile 
                85                  90                  95      


Trp Gly Trp Ser 
            100 


<210>  6
<211>  50
<212>  PRT
<213>  ˹

<400>  6

Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu 
1               5                   10                  15      


Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met 
            20                  25                  30          


Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly 
        35                  40                  45              


Thr Ala 
    50  


<210>  7
<211>  238
<212>  PRT
<213>  ˹

<400>  7

Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
1               5                   10                  15      


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
            20                  25                  30          


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
        35                  40                  45              


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
    50                  55                  60                  


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
65                  70                  75                  80  


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
                85                  90                  95      


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
            100                 105                 110         


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
        115                 120                 125             


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
    130                 135                 140                 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
145                 150                 155                 160 


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
                165                 170                 175     


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
            180                 185                 190         


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
        195                 200                 205             


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
    210                 215                 220                 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
225                 230                 235             


<210>  8
<211>  101
<212>  PRT
<213>  ˹

<400>  8

Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val 
1               5                   10                  15      


Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn 
            20                  25                  30          


Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val 
        35                  40                  45              


Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val 
    50                  55                  60                  


Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val 
65                  70                  75                  80  


Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile 
                85                  90                  95      


Trp Gly Trp Ser Tyr 
            100     


<210>  9
<211>  253
<212>  PRT
<213>  ˹

<400>  9

Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln 
1               5                   10                  15      


Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg 
        35                  40                  45              


Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val 
    50                  55                  60                  


Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln 
65                  70                  75                  80  


Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn 
                85                  90                  95      


Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu 
            100                 105                 110         


Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala 
        115                 120                 125             


Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr 
    130                 135                 140                 


Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys 
145                 150                 155                 160 


Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr 
                165                 170                 175     


Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile 
            180                 185                 190         


Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu 
        195                 200                 205             


Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu 
    210                 215                 220                 


Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys 
225                 230                 235                 240 


Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala 
                245                 250             


<210>  10
<211>  101
<212>  PRT
<213>  ˹

<400>  10

Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val 
1               5                   10                  15      


Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp 
            20                  25                  30          


Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala 
        35                  40                  45              


Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser 
    50                  55                  60                  


Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr 
65                  70                  75                  80  


Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp 
                85                  90                  95      


Glu Ala Ile Asn Ile 
            100     


<210>  11
<211>  283
<212>  PRT
<213>  ˹

<400>  11

Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln 
1               5                   10                  15      


Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg 
        35                  40                  45              


Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val 
    50                  55                  60                  


Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln 
65                  70                  75                  80  


Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn 
                85                  90                  95      


Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu 
            100                 105                 110         


Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala 
        115                 120                 125             


Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr 
    130                 135                 140                 


Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys 
145                 150                 155                 160 


Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr 
                165                 170                 175     


Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile 
            180                 185                 190         


Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu 
        195                 200                 205             


Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu 
    210                 215                 220                 


Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys 
225                 230                 235                 240 


Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe 
                245                 250                 255     


Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys 
            260                 265                 270         


Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
        275                 280             


<210>  12
<211>  81
<212>  PRT
<213>  ˹

<400>  12

Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val 
1               5                   10                  15      


Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp 
            20                  25                  30          


Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala 
        35                  40                  45              


Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser 
    50                  55                  60                  


Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr 
65                  70                  75                  80  


Ile 
    


<210>  13
<211>  51
<212>  PRT
<213>  ˹

<400>  13

Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr 
1               5                   10                  15      


Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys 
            20                  25                  30          


Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala 
        35                  40                  45              


Ile Asn Ile 
    50      


<210>  14
<211>  735
<212>  PRT
<213>  ˹

<400>  14

Leu Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala 
1               5                   10                  15      


Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe 
            20                  25                  30          


Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp 
        35                  40                  45              


Asn Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile 
    50                  55                  60                  


Leu Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu 
65                  70                  75                  80  


Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro 
                245                 250                 255     


Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr 
            260                 265                 270         


Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln 
        275                 280                 285             


Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr 
    290                 295                 300                 


Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly 
305                 310                 315                 320 


Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala 
                325                 330                 335     


Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile 
            340                 345                 350         


His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly 
        355                 360                 365             


Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe 
    370                 375                 380                 


Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr 
385                 390                 395                 400 


Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys 
                405                 410                 415     


His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp 
            420                 425                 430         


Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile 
        435                 440                 445             


Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu 
    450                 455                 460                 


Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys 
465                 470                 475                 480 


Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys 
                485                 490                 495     


Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu 
            500                 505                 510         


Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe 
        515                 520                 525             


Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile 
    530                 535                 540                 


Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu 
545                 550                 555                 560 


Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile 
                565                 570                 575     


Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg 
            580                 585                 590         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala 
        595                 600                 605             


Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro 
    610                 615                 620                 


Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met 
625                 630                 635                 640 


Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr 
                645                 650                 655     


Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile 
            660                 665                 670         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile 
        675                 680                 685             


Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr 
    690                 695                 700                 


Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
                725                 730                 735 


<210>  15
<211>  255
<212>  PRT
<213>  ˹

<400>  15

Leu Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala 
1               5                   10                  15      


Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe 
            20                  25                  30          


Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp 
        35                  40                  45              


Asn Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile 
    50                  55                  60                  


Leu Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu 
65                  70                  75                  80  


Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu 
                85                  90                  95      


Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn 
            100                 105                 110         


Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu 
        115                 120                 125             


Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn 
    130                 135                 140                 


Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe 
145                 150                 155                 160 


Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr 
                165                 170                 175     


Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn 
            180                 185                 190         


Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val 
        195                 200                 205             


Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn 
    210                 215                 220                 


Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe 
225                 230                 235                 240 


Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val 
                245                 250                 255 


<210>  16
<211>  31
<212>  PRT
<213>  ˹

<400>  16

Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser 
1               5                   10                  15      


Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
            20                  25                  30      


<210>  17
<211>  51
<212>  PRT
<213>  ˹

<400>  17

Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val Ser Thr Pro 
1               5                   10                  15      


Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys 
            20                  25                  30          


Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val Glu Asn Ala 
        35                  40                  45              


Ile Gln Ile 
    50      


<210>  18
<211>  50
<212>  PRT
<213>  ˹

<400>  18

Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
1               5                   10                  15      


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
            20                  25                  30          


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
        35                  40                  45              


Tyr Ile 
    50  


<210>  19
<211>  260
<212>  PRT
<213>  ˹

<400>  19

Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile Cys Asp 
1               5                   10                  15      


Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln Glu His 
            20                  25                  30          


Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val Ser Thr 
        35                  40                  45              


Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe Ser Asp 
    50                  55                  60                  


Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val Glu Asn 
65                  70                  75                  80  


Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile Phe Arg 
                85                  90                  95      


Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu Glu Tyr 
            100                 105                 110         


Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr Pro Pro 
        115                 120                 125             


Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys Gln Tyr 
    130                 135                 140                 


Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu Val Cys 
145                 150                 155                 160 


Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg Thr Asp 
                165                 170                 175     


Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn Ala Leu 
            180                 185                 190         


Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu Val Asp 
        195                 200                 205             


Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe Asp Arg 
    210                 215                 220                 


Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro Cys Ser 
225                 230                 235                 240 


Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr Leu Ala 
                245                 250                 255     


Ser Lys Glu Gly 
            260 


<210>  20
<211>  27
<212>  PRT
<213>  ˹

<400>  20

Ala Ala Leu Ala Leu Val Val Ile Cys Ile Val Leu Arg Pro Ser Arg 
1               5                   10                  15      


Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala 
            20                  25          


<210>  21
<211>  220
<212>  PRT
<213>  ˹

<400>  21

Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe Ala Val Asn Trp 
1               5                   10                  15      


Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile Ala Leu Val Asp 
            20                  25                  30          


Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu His Ala Val Tyr 
        35                  40                  45              


Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Leu Thr Ala Val Arg 
    50                  55                  60                  


Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Glu Arg Ile Ala Ile Trp 
65                  70                  75                  80  


Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly 
                85                  90                  95      


Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp 
            100                 105                 110         


Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly Leu Pro Thr 
        115                 120                 125             


Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg 
    130                 135                 140                 


Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala 
145                 150                 155                 160 


Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu 
                165                 170                 175     


Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn 
            180                 185                 190         


His Gly Ile Ser Ser Gly Arg Ser Gln Asn His Leu Tyr Thr His Met 
        195                 200                 205             


Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp 
    210                 215                 220 


<210>  22
<211>  722
<212>  PRT
<213>  ˹

<400>  22

Met Arg Ala Leu Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr 
1               5                   10                  15      


Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln 
            20                  25                  30          


Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser 
        35                  40                  45              


Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn 
    50                  55                  60                  


Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr 
65                  70                  75                  80  


Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp 
                85                  90                  95      


Leu Ser Asn Gly Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile 
            100                 105                 110         


Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr 
        115                 120                 125             


Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln 
    130                 135                 140                 


Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp 
145                 150                 155                 160 


Trp Val Tyr Glu Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp 
                165                 170                 175     


Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp 
            180                 185                 190         


Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg 
        195                 200                 205             


Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val 
    210                 215                 220                 


Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln 
225                 230                 235                 240 


Glu Val Pro Val Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser 
                245                 250                 255     


Trp Leu Thr Trp Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys 
            260                 265                 270         


Arg Val Gln Asn Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp 
        275                 280                 285             


Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser 
    290                 295                 300                 


Arg Thr Gly Trp Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser 
305                 310                 315                 320 


Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr 
                325                 330                 335     


Lys His Ile His Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile 
            340                 345                 350         


Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp 
        355                 360                 365             


Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg 
    370                 375                 380                 


Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys 
385                 390                 395                 400 


Val Thr Cys His Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser 
                405                 410                 415     


Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly 
            420                 425                 430         


Ile Pro Ile Ser Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys 
        435                 440                 445             


Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln 
    450                 455                 460                 


Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu 
465                 470                 475                 480 


Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr 
                485                 490                 495     


Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg 
            500                 505                 510         


Ser Val Phe Ala Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly 
        515                 520                 525             


Met Val Ile Ala Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp 
    530                 535                 540                 


Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu 
545                 550                 555                 560 


Asp Gln Ile Thr Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp 
                565                 570                 575     


Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser 
            580                 585                 590         


Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala 
        595                 600                 605             


Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu 
    610                 615                 620                 


Arg Phe Met Gly Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys 
625                 630                 635                 640 


Asn Ser Thr Val Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr 
                645                 650                 655     


Leu Leu Ile His Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser 
            660                 665                 670         


Ala Gln Ile Ala Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala 
        675                 680                 685             


Met Trp Tyr Ser Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn 
    690                 695                 700                 


His Leu Tyr Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu 
705                 710                 715                 720 


Ser Asp 
        


