﻿                         序列表

<110>  上海鑫湾生物科技有限公司

<120>  共表达IL-21和hrCD16嵌合受体的免疫细胞及其应用

<130>  EIC20310013P

<150>  202010645503X
<151>  2020-07-06

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  208
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         
Gly Leu Ala Val Pro Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             

<210>  2
<211>  45
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  3
<211>  24
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  

<210>  4
<211>  42
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210>  5
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210>  6
<211>  433
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      
Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          
Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              
Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  
Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  
Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      
Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         
Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             
His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 
Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 
Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     
Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         
Gly Leu Ala Val Pro Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             
Thr Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    210                 215                 220                 
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
225                 230                 235                 240 
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                245                 250                 255     
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            260                 265                 270         
Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        275                 280                 285             
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    290                 295                 300                 
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
305                 310                 315                 320 
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                325                 330                 335     
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            340                 345                 350         
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        355                 360                 365             
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    370                 375                 380                 
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
385                 390                 395                 400 
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                405                 410                 415     
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            420                 425                 430         
Arg 
    

<210>  7
<211>  162
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      
Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          
Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              
Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  
Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  
Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      
Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         
Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             
Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 
Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 
Asp Ser 
        

<210>  8
<211>  1860
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
atgtggcagc tgctgctccc taccgctctc ctgctcctcg tgagcgccgg catgcgcaca        60
gaggacctcc caaaggctgt ggtgttcctg gagcctcagt ggtaccgggt gctcgagaag       120
gactctgtga cactgaagtg ccagggcgct tacagccccg aggacaactc tacccagtgg       180
ttccacaacg agtctctgat ttcttctcag gccagttctt acttcattga cgccgctaca       240
gtggacgaca gcggcgagta cagatgccag acaaacctga gcacactgtc cgaccccgtg       300
cagctggagg tgcacatcgg atggctgctc ctccaggccc ctagatgggt gttcaaggag       360
gaggacccta ttcacctgag atgccactct tggaagaaca ccgccctgca caaggtgaca       420
tacctgcaga acggaaaggg acgcaagtac ttccaccaca actccgactt ctacattcca       480
aaggctacac tgaaggactc tgggtcttac ttctgccgcg gcctcgtggg atctaagaac       540
gtgtctagcg agaccgtgaa cattaccatc acccagggcc tcgccgtgcc aacaattagc       600
agcttcttcc cacccggata ccagacgcgt acaacaaccc cagcccctag gcctccaaca       660
ccagccccaa caatcgcttc tcagccactg tctctcagac ccgaggcttg ccggcctgcc       720
gctggcgggg ccgtgcacac acggggactc gacttcgctt gcgacattta catttgggcc       780
ccactcgctg gaacatgcgg cgtgctcctg ctgtctctgg tgatcacact gtactgcaag       840
cgcgggcgca agaagctgct ctacatcttc aagcagccat tcatgagacc cgtgcagacc       900
acacaggagg aggacggatg ctcttgccgg ttccctgagg aggaggaggg cggatgcgag       960
ctcagagtga agttctctag atctgctgac gccccagctt acaagcaggg gcagaaccag      1020
ctgtacaacg agctcaacct cggccggcgc gaggagtacg acgtgctcga caagcggcgc      1080
ggaagagacc cagagatggg cggaaagcct agaagaaaga accctcagga gggactgtac      1140
aacgagctcc agaaggacaa gatggctgag gcttactccg agattggaat gaagggagag      1200
cggcgcagag gcaaggggca cgacggcctg taccagggac tgtctaccgc caccaaggac      1260
acatacgacg ccctgcacat gcaggccctc ccacctagag gatccggaag cggagctact      1320
aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tatgcggtct      1380
agccccggaa acatggagcg catcgtgatt tgcctcatgg tgattttcct cgggacactc      1440
gtgcacaagt cttctagcca ggggcaggac aggcacatga ttcgcatgag acagctgatc      1500
gacattgtgg accagctgaa gaactacgtg aacgacctgg tgcccgagtt cctccccgcc      1560
ccagaggacg tggagacaaa ctgcgagtgg tccgctttct cttgcttcca gaaggcccag      1620
ctgaagtccg ccaacaccgg aaacaacgag agaattatta acgtgtctat taagaagctg      1680
aagcgcaagc ccccatctac caacgccggg cggcggcaga agcaccggct cacatgccca      1740
tcttgcgact cttacgagaa gaagccccct aaggagttcc ttgaacggtt caagtccctg      1800
ctccagaaga tgatccacca gcacctgtct agccggaccc acgggtccga ggactcttga      1860

<210>  9
<211>  1299
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
atgtggcagc tgctgctccc taccgctctc ctgctcctcg tgagcgccgg catgcgcaca        60
gaggacctcc caaaggctgt ggtgttcctg gagcctcagt ggtaccgggt gctcgagaag       120
gactctgtga cactgaagtg ccagggcgct tacagccccg aggacaactc tacccagtgg       180
ttccacaacg agtctctgat ttcttctcag gccagttctt acttcattga cgccgctaca       240
gtggacgaca gcggcgagta cagatgccag acaaacctga gcacactgtc cgaccccgtg       300
cagctggagg tgcacatcgg atggctgctc ctccaggccc ctagatgggt gttcaaggag       360
gaggacccta ttcacctgag atgccactct tggaagaaca ccgccctgca caaggtgaca       420
tacctgcaga acggaaaggg acgcaagtac ttccaccaca actccgactt ctacattcca       480
aaggctacac tgaaggactc tgggtcttac ttctgccgcg gcctcttcgg atctaagaac       540
gtgtctagcg agaccgtgaa cattaccatc acccagggcc tcgccgtgtc aacaattagc       600
agcttcttcc cacccggata ccagacgcgt acaacaaccc cagcccctag gcctccaaca       660
ccagccccaa caatcgcttc tcagccactg tctctcagac ccgaggcttg ccggcctgcc       720
gctggcgggg ccgtgcacac acggggactc gacttcgctt gcgacattta catttgggcc       780
ccactcgctg gaacatgcgg cgtgctcctg ctgtctctgg tgatcacact gtactgcaag       840
cgcgggcgca agaagctgct ctacatcttc aagcagccat tcatgagacc cgtgcagacc       900
acacaggagg aggacggatg ctcttgccgg ttccctgagg aggaggaggg cggatgcgag       960
ctcagagtga agttctctag atctgctgac gccccagctt acaagcaggg gcagaaccag      1020
ctgtacaacg agctcaacct cggccggcgc gaggagtacg acgtgctcga caagcggcgc      1080
ggaagagacc cagagatggg cggaaagcct agaagaaaga accctcagga gggactgtac      1140
aacgagctcc agaaggacaa gatggctgag gcttactccg agattggaat gaagggagag      1200
cggcgcagag gcaaggggca cgacggcctg taccagggac tgtctaccgc caccaaggac      1260
acatacgacg ccctgcacat gcaggccctc ccacctaga                             1299

<210>  10
<211>  1299
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
atgtggcagc tgctgctccc taccgctctc ctgctcctcg tgagcgccgg catgcgcaca        60
gaggacctcc caaaggctgt ggtgttcctg gagcctcagt ggtaccgggt gctcgagaag       120
gactctgtga cactgaagtg ccagggcgct tacagccccg aggacaactc tacccagtgg       180
ttccacaacg agtctctgat ttcttctcag gccagttctt acttcattga cgccgctaca       240
gtggacgaca gcggcgagta cagatgccag acaaacctga gcacactgtc cgaccccgtg       300
cagctggagg tgcacatcgg atggctgctc ctccaggccc ctagatgggt gttcaaggag       360
gaggacccta ttcacctgag atgccactct tggaagaaca ccgccctgca caaggtgaca       420
tacctgcaga acggaaaggg acgcaagtac ttccaccaca actccgactt ctacattcca       480
aaggctacac tgaaggactc tgggtcttac ttctgccgcg gcctcgtggg atctaagaac       540
gtgtctagcg agaccgtgaa cattaccatc acccagggcc tcgccgtgcc aacaattagc       600
agcttcttcc cacccggata ccagacgcgt acaacaaccc cagcccctag gcctccaaca       660
ccagccccaa caatcgcttc tcagccactg tctctcagac ccgaggcttg ccggcctgcc       720
gctggcgggg ccgtgcacac acggggactc gacttcgctt gcgacattta catttgggcc       780
ccactcgctg gaacatgcgg cgtgctcctg ctgtctctgg tgatcacact gtactgcaag       840
cgcgggcgca agaagctgct ctacatcttc aagcagccat tcatgagacc cgtgcagacc       900
acacaggagg aggacggatg ctcttgccgg ttccctgagg aggaggaggg cggatgcgag       960
ctcagagtga agttctctag atctgctgac gccccagctt acaagcaggg gcagaaccag      1020
ctgtacaacg agctcaacct cggccggcgc gaggagtacg acgtgctcga caagcggcgc      1080
ggaagagacc cagagatggg cggaaagcct agaagaaaga accctcagga gggactgtac      1140
aacgagctcc agaaggacaa gatggctgag gcttactccg agattggaat gaagggagag      1200
cggcgcagag gcaaggggca cgacggcctg taccagggac tgtctaccgc caccaaggac      1260
acatacgacg ccctgcacat gcaggccctc ccacctaga                             1299

