                         SEQUENCE LISTING

<110>  Immunocore Limited
 
<120>  Specific Binding Molecules

<130>  P136555WO

<150> GB2010329.7
<151> 6 July 2020

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Seq_ID_1

<400>  1

Arg Leu Pro Ala Lys Ala Pro Leu Leu 
1               5                   


<210>  2
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn 
            20                  25                  30          


Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu 
        35                  40                  45              


Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala 
    50                  55                  60                  


Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr Asn Gln Ala 
                85                  90                  95      


Gly Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser Val Ser Ser 
            100                 105                 110         


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
        115                 120                 125             


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
    130                 135                 140                 


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys 
145                 150                 155                 160 


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
                165                 170                 175     


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
            180                 185                 190         


Ile Ile Pro Glu Asp Thr 
        195             


<210>  3
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ser Gln Asp Met Asn His Glu Tyr Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser 
                85                  90                  95      


Ile Arg Gly Ser Arg Gly Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
        115                 120                 125             


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
    210                 215                 220                 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp 
                245 


<210>  4
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Met Asp Ser Ser Tyr 
                85                  90                  95      


Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu Leu Val Arg Pro Asp Ile 
            100                 105                 110         


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
        115                 120                 125             


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
    130                 135                 140                 


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu 
145                 150                 155                 160 


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
                165                 170                 175     


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
            180                 185                 190         


Pro Glu Asp Thr 
        195     


<210>  5
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Leu 
                85                  90                  95      


Ala Thr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Val 
            100                 105                 110         


Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        115                 120                 125             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys 
                165                 170                 175     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    210                 215                 220                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp 
        


<210>  6
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain variable domain

<400>  6

Ala Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Pro Asp Gly Asp Gln Ala 
            20                  25                  30          


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
        35                  40                  45              


Ser Leu Leu Leu Ile Gln Ser Ser Lys Arg Glu Gln Thr Ser Gly Arg 
    50                  55                  60                  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
65                  70                  75                  80  


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr 
                85                  90                  95      


Gly Glu Ser Gly Val Tyr Trp Val Phe Gly Lys Gly Thr Thr Leu Ser 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain variable domain

<400>  7

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Arg Ser Arg Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Met Asp Arg Glu Tyr 
                85                  90                  95      


Glu Ile Ser Phe Gly Ser Gly Thr Arg Leu Leu Val Arg Pro 
            100                 105                 110 


<210>  8
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain variable domain

<400>  8

Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly 
1               5                   10                  15      


Gln Ser Met Thr Leu Gln Cys Ser Gln Asp Met Lys His Glu Phe Met 
            20                  25                  30          


Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr 
        35                  40                  45              


Ser Leu Gly Val Asp Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr 
    50                  55                  60                  


Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser 
65                  70                  75                  80  


Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser 
                85                  90                  95      


Ile Arg Gly Ser Arg Gly Glu Leu Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  9
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain variable domain

<400>  9

Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Asp His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Ser Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Leu 
                85                  90                  95      


Gly Pro Asn Glu Gln Leu Phe Gly Pro Gly Thr Arg Leu Thr Val Val 
            100                 105                 110         


<210>  10
<211>  201
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR-antiCD3 fusions proteins

<400>  10

Ala Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Pro Asp Gly Asp Gln Ala 
            20                  25                  30          


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
        35                  40                  45              


Ser Leu Leu Leu Ile Gln Ser Ser Lys Arg Glu Gln Thr Ser Gly Arg 
    50                  55                  60                  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
65                  70                  75                  80  


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr 
                85                  90                  95      


Gly Glu Ser Gly Val Tyr Trp Val Phe Gly Lys Gly Thr Thr Leu Ser 
            100                 105                 110         


Val Ser Ser Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
        115                 120                 125             


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
                165                 170                 175     


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
            180                 185                 190         


Asn Asn Ser Ile Ile Pro Glu Asp Thr 
        195                 200     


<210>  11
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR-antiCD3 fusions proteins

<400>  11

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys 
            260                 265                 270         


Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Lys His Glu 
        275                 280                 285             


Phe Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile 
    290                 295                 300                 


His Tyr Ser Leu Gly Val Asp Ile Thr Asp Gln Gly Glu Val Pro Asn 
305                 310                 315                 320 


Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu 
                325                 330                 335     


Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser 
            340                 345                 350         


Tyr Ser Ile Arg Gly Ser Arg Gly Glu Leu Phe Phe Gly Pro Gly Thr 
        355                 360                 365             


Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    370                 375                 380                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
385                 390                 395                 400 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                405                 410                 415     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            420                 425                 430         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala 
        435                 440                 445             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg 
    450                 455                 460                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
465                 470                 475                 480 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                485                 490                 495     


Glu Ala Trp Gly Arg Ala Asp 
            500             


<210>  12
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR-antiCD3 fusions proteins

<400>  12

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Phe Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys 
            260                 265                 270         


Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Lys His Glu 
        275                 280                 285             


Phe Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile 
    290                 295                 300                 


His Tyr Ser Leu Gly Val Asp Ile Thr Asp Gln Gly Glu Val Pro Asn 
305                 310                 315                 320 


Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu 
                325                 330                 335     


Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser 
            340                 345                 350         


Tyr Ser Ile Arg Gly Ser Arg Gly Glu Leu Phe Phe Gly Pro Gly Thr 
        355                 360                 365             


Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    370                 375                 380                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
385                 390                 395                 400 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                405                 410                 415     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            420                 425                 430         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala 
        435                 440                 445             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg 
    450                 455                 460                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
465                 470                 475                 480 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                485                 490                 495     


Glu Ala Trp Gly Arg Ala Asp 
            500             


<210>  13
<211>  196
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR-antiCD3 fusions proteins

<400>  13

Ala Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Arg Ser Arg Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Met Asp Arg Glu Tyr 
                85                  90                  95      


Glu Ile Ser Phe Gly Ser Gly Thr Arg Leu Leu Val Arg Pro Asp Ile 
            100                 105                 110         


Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser 
        115                 120                 125             


Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val 
    130                 135                 140                 


Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu 
145                 150                 155                 160 


Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
                165                 170                 175     


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
            180                 185                 190         


Pro Glu Asp Thr 
        195     


<210>  14
<211>  500
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR-antiCD3 fusions proteins

<400>  14

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe 
145                 150                 155                 160 


Thr Gly Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn 
            180                 185                 190         


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn 
        195                 200                 205             


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr Lys 
            260                 265                 270         


Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Asp His Asn 
        275                 280                 285             


Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu 
    290                 295                 300                 


Thr Tyr Phe Gln Ser Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser 
305                 310                 315                 320 


Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu 
                325                 330                 335     


Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser 
            340                 345                 350         


Ser Leu Gly Pro Asn Glu Gln Leu Phe Gly Pro Gly Thr Arg Leu Thr 
        355                 360                 365             


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
    370                 375                 380                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
385                 390                 395                 400 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
                405                 410                 415     


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro 
            420                 425                 430         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser 
        435                 440                 445             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His Phe 
    450                 455                 460                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
465                 470                 475                 480 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                485                 490                 495     


Gly Arg Ala Asp 
            500 


<210>  15
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  16

Gly Gly Gly Ser Gly 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  17

Gly Gly Ser Gly Gly 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  18

Gly Ser Gly Gly Gly 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  19

Gly Ser Gly Gly Gly Pro 
1               5       


<210>  20
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  20

Gly Gly Glu Pro Ser 
1               5   


<210>  21
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  21

Gly Gly Glu Gly Gly Gly Pro 
1               5           


<210>  22
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  22

Gly Gly Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
1               5                   10          


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  23

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  24

Gly Gly Gly Ser 
1               


<210>  25
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  25

Thr Val Leu Arg Thr 
1               5   


<210>  26
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  26

Thr Val Ser Ser Ala Ser 
1               5       


<210>  27
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  27

Thr Val Leu Ser Ser Ala Ser 
1               5           


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR1

<400>  28

Asp Ser Ala Ile Tyr Asn 
1               5       


<210>  29
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR2

<400>  29

Ile Gln Ser Ser Gln Arg Glu 
1               5           


<210>  30
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR3

<400>  30

Cys Ala Val Thr Asn Gln Ala Gly Thr Ala Leu Ile Phe 
1               5                   10              


<210>  31
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  31

Met Asn His Glu Tyr 
1               5   


<210>  32
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR2

<400>  32

Ser Val Gly Ala Gly Ile 
1               5       


<210>  33
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  33

Cys Ala Ser Ser Tyr Ser Ile Arg Gly Ser Arg Gly Glu Gln Phe Phe 
1               5                   10                  15      


<210>  34
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR1

<400>  34

Pro Asp Gly Asp Gln Ala Ile Tyr Asn 
1               5                   


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR2

<400>  35

Ile Gln Ser Ser Lys Arg Glu 
1               5           


<210>  36
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR3

<400>  36

Cys Ala Val Thr Gly Glu Ser Gly Val Tyr Trp Val Phe 
1               5                   10              


<210>  37
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  37

Met Lys His Glu Phe 
1               5   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR2

<400>  38

Ser Leu Gly Val Asp Ile 
1               5       


<210>  39
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  39

Cys Ala Ser Ser Tyr Ser Ile Arg Gly Ser Arg Gly Glu Leu Phe Phe 
1               5                   10                  15      


<210>  40
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR1

<400>  40

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR2

<400>  41

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  42
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR3

<400>  42

Cys Ala Val Met Asp Ser Ser Tyr Lys Leu Ile Phe 
1               5                   10          


<210>  43
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  43

Ser Glu His Asn Arg 
1               5   


<210>  44
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR2

<400>  44

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  45
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  45

Cys Ala Ser Ser Leu Ala Thr Asn Glu Gln Phe Phe 
1               5                   10          


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR1

<400>  46

Asp Arg Arg Ser Arg Ser 
1               5       


<210>  47
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha chain CDR3

<400>  47

Cys Ala Val Met Asp Arg Glu Tyr Glu Ile Ser Phe 
1               5                   10          


<210>  48
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR1

<400>  48

Ser Asp His Asn Arg 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR2

<400>  49

Phe Gln Ser Glu Ala Gln 
1               5       


<210>  50
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  beta chain CDR3

<400>  50

Cys Ala Ser Ser Leu Gly Pro Asn Glu Gln Leu Phe 
1               5                   10          


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HLA-A*02:01

<400>  51

Val Met Ala Pro Arg Thr Leu Val Leu 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HLA-C*03:03

<400>  52

Val Met Ala Pro Arg Thr Leu Ile Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HLA-A*03:01

<400>  53

Val Met Ala Pro Arg Thr Leu Leu Leu 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HLA-C*07:01

<400>  54

Val Met Ala Pro Arg Ala Leu Leu Leu 
1               5                   


<210>  55
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AyiTag

<400>  55

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


