                         SEQUENCE LISTING

<110>  Children's Medical Center Corporation
 
<120>  MYBPC3 POLYPEPTIDES AND USES THEREOF

<130>  C1233.70191WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/049,398
<151>  2020-07-08

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  1277
<212>  PRT
<213>  Mus musculus

<400>  1

Pro Gly Val Thr Val Leu Lys Met Pro Glu Pro Gly Lys Lys Pro Val 
1               5                   10                  15      


Ser Ala Phe Asn Lys Lys Pro Arg Ser Ala Glu Val Thr Ala Gly Ser 
            20                  25                  30          


Ala Ala Val Phe Glu Ala Glu Thr Glu Arg Ser Gly Val Lys Val Arg 
        35                  40                  45              


Trp Gln Arg Asp Gly Ser Asp Ile Thr Ala Asn Asp Lys Tyr Gly Leu 
    50                  55                  60                  


Ala Ala Glu Gly Lys Arg His Thr Leu Thr Val Arg Asp Ala Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Gly Ser Tyr Ala Val Ile Ala Gly Ser Ser Lys Val Lys 
                85                  90                  95      


Phe Asp Leu Lys Val Thr Glu Pro Ala Pro Pro Glu Lys Ala Glu Ser 
            100                 105                 110         


Glu Val Ala Pro Gly Ala Pro Lys Glu Val Pro Ala Pro Ala Thr Glu 
        115                 120                 125             


Leu Glu Glu Ser Val Ser Ser Pro Glu Gly Ser Val Ser Val Thr Gln 
    130                 135                 140                 


Asp Gly Ser Ala Ala Glu His Gln Gly Ala Pro Asp Asp Pro Ile Gly 
145                 150                 155                 160 


Leu Phe Leu Met Arg Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser 
                165                 170                 175     


Ile Val Phe Ser Ala Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro 
            180                 185                 190         


Val Val Lys Trp Phe Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val 
        195                 200                 205             


Gly Gln His Leu Gln Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val 
    210                 215                 220                 


Tyr Leu Phe Glu Leu His Ile Thr Asp Ala Gln Thr Thr Ser Ala Gly 
225                 230                 235                 240 


Gly Tyr Arg Cys Glu Val Ser Thr Lys Asp Lys Phe Asp Ser Cys Asn 
                245                 250                 255     


Phe Asn Leu Thr Val His Glu Ala Ile Gly Ser Gly Asp Leu Asp Leu 
            260                 265                 270         


Arg Ser Ala Phe Arg Arg Thr Ser Leu Ala Gly Ala Gly Arg Arg Thr 
        275                 280                 285             


Ser Asp Ser His Glu Asp Ala Gly Thr Leu Asp Phe Ser Ser Leu Leu 
    290                 295                 300                 


Lys Lys Arg Asp Ser Phe Arg Arg Asp Ser Lys Leu Glu Ala Pro Ala 
305                 310                 315                 320 


Glu Glu Asp Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr 
                325                 330                 335     


Glu Arg Ile Ala Phe Gln His Gly Val Thr Asp Leu Arg Gly Met Leu 
            340                 345                 350         


Lys Arg Leu Lys Gly Met Lys Gln Asp Glu Lys Lys Ser Thr Ala Phe 
        355                 360                 365             


Gln Lys Lys Leu Glu Pro Ala Tyr Gln Val Asn Lys Gly His Lys Ile 
    370                 375                 380                 


Arg Leu Thr Val Glu Leu Ala Asp Pro Asp Ala Glu Val Lys Trp Leu 
385                 390                 395                 400 


Lys Asn Gly Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu 
                405                 410                 415     


Ser Val Gly Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala 
            420                 425                 430         


Asp Asp Ala Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr 
        435                 440                 445             


Glu Leu Phe Val Lys Glu Pro Pro Val Leu Ile Thr Arg Ser Leu Glu 
    450                 455                 460                 


Asp Gln Leu Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val 
465                 470                 475                 480 


Ser Glu Glu Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu 
                485                 490                 495     


Thr Arg Glu Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Arg Lys 
            500                 505                 510         


His His Leu Ile Ile Asn Glu Ala Thr Leu Glu Asp Ala Gly His Tyr 
        515                 520                 525             


Ala Val Arg Thr Ser Gly Gly Gln Ser Leu Ala Glu Leu Ile Val Gln 
    530                 535                 540                 


Glu Lys Lys Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Ala Val Gly 
545                 550                 555                 560 


Ala Lys Asp Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val 
                565                 570                 575     


Arg Gly Val Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Asn Arg 
            580                 585                 590         


Ile Lys Val Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp 
        595                 600                 605             


Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe 
    610                 615                 620                 


Ala Cys Asn Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp 
625                 630                 635                 640 


Phe Val Pro Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly 
                645                 650                 655     


Ser Thr Pro Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu 
            660                 665                 670         


Asp Val Pro Ile Ser Gly Asp Pro Ala Pro Thr Val Val Trp Gln Lys 
        675                 680                 685             


Thr Val Thr Gln Gly Lys Lys Ala Ser Thr Gly Pro His Pro Asp Ala 
    690                 695                 700                 


Pro Glu Asp Ala Gly Ala Asp Glu Glu Trp Val Phe Asp Lys Lys Leu 
705                 710                 715                 720 


Leu Cys Glu Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg 
                725                 730                 735     


Ser Val Phe Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr 
            740                 745                 750         


Thr Val Thr Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr 
        755                 760                 765             


Val Lys Val Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser 
    770                 775                 780                 


Asn Val Gly Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr 
785                 790                 795                 800 


Asp Gly Gly Gln Pro Val Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys 
                805                 810                 815     


Lys Ser Tyr Arg Trp Met Arg Leu Asn Phe Asp Leu Leu Arg Glu Leu 
            820                 825                 830         


Ser His Glu Ala Arg Arg Met Ile Glu Gly Val Ala Tyr Glu Met Arg 
        835                 840                 845             


Val Tyr Ala Val Asn Ala Val Gly Met Ser Arg Pro Ser Pro Ala Ser 
    850                 855                 860                 


Gln Pro Phe Met Pro Ile Gly Pro Pro Gly Glu Pro Thr His Leu Ala 
865                 870                 875                 880 


Val Glu Asp Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro 
                885                 890                 895     


Glu Arg Val Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys 
            900                 905                 910         


Gln Glu Gly Cys Ser Glu Trp Thr Pro Ala Leu Gln Gly Leu Thr Glu 
        915                 920                 925             


Arg Thr Ser Met Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu 
    930                 935                 940                 


Phe Arg Val Arg Ala His Asn Val Ala Gly Pro Gly Gly Pro Ile Val 
945                 950                 955                 960 


Thr Lys Glu Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu 
                965                 970                 975     


Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu 
            980                 985                 990         


Pro Val Asn Leu Leu Ile Pro Phe  Gln Gly Lys Pro Arg  Pro Gln Val 
        995                 1000                 1005             


Thr Trp  Thr Lys Glu Gly Gln  Pro Leu Ala Gly Glu  Glu Val Ser 
    1010                 1015                 1020             


Ile Arg  Asn Ser Pro Thr Asp  Thr Ile Leu Phe Ile  Arg Ala Ala 
    1025                 1030                 1035             


Arg Arg  Thr His Ser Gly Thr  Tyr Gln Val Thr Val  Arg Ile Glu 
    1040                 1045                 1050             


Asn Met  Glu Asp Lys Ala Thr  Leu Ile Leu Gln Ile  Val Asp Lys 
    1055                 1060                 1065             


Pro Ser  Pro Pro Gln Asp Ile  Arg Ile Val Glu Thr  Trp Gly Phe 
    1070                 1075                 1080             


Asn Val  Ala Leu Glu Trp Lys  Pro Pro Gln Asp Asp  Gly Asn Thr 
    1085                 1090                 1095             


Glu Ile  Trp Gly Tyr Thr Val  Gln Lys Ala Asp Lys  Lys Thr Met 
    1100                 1105                 1110             


Glu Trp  Phe Thr Val Leu Glu  His Tyr Arg Arg Thr  His Cys Val 
    1115                 1120                 1125             


Val Ser  Glu Leu Ile Ile Gly  Asn Gly Tyr Tyr Phe  Arg Val Phe 
    1130                 1135                 1140             


Ser His  Asn Met Val Gly Ser  Ser Asp Lys Ala Ala  Ala Thr Lys 
    1145                 1150                 1155             


Glu Pro  Val Phe Ile Pro Arg  Pro Gly Ile Thr Tyr  Glu Pro Pro 
    1160                 1165                 1170             


Lys Tyr  Lys Ala Leu Asp Phe  Ser Glu Ala Pro Ser  Phe Thr Gln 
    1175                 1180                 1185             


Pro Leu  Ala Asn Arg Ser Ile  Ile Ala Gly Tyr Asn  Ala Ile Leu 
    1190                 1195                 1200             


Cys Cys  Ala Val Arg Gly Ser  Pro Lys Pro Lys Ile  Ser Trp Phe 
    1205                 1210                 1215             


Lys Asn  Gly Leu Asp Leu Gly  Glu Asp Ala Arg Phe  Arg Met Phe 
    1220                 1225                 1230             


Cys Lys  Gln Gly Val Leu Thr  Leu Glu Ile Arg Lys  Pro Cys Pro 
    1235                 1240                 1245             


Tyr Asp  Gly Gly Val Tyr Val  Cys Arg Ala Thr Asn  Leu Gln Gly 
    1250                 1255                 1260             


Glu Ala  Gln Cys Glu Cys Arg  Leu Glu Val Arg Val  Pro Gln 
    1265                 1270                 1275         


<210>  2
<211>  194
<212>  PRT
<213>  Mus musculus

<400>  2

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Val Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Leu Arg Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Ala Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Val Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp Thr 
    130                 135                 140                 


Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Val 
                165                 170                 175     


Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile 
        


<210>  3
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Val Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Leu Arg Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Ala Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Val Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp Thr 
    130                 135                 140                 


Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Val 
                165                 170                 175     


Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
        195                 200                 205             


Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe 
    210                 215                 220                 


Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro 
225                 230                 235                 240 


Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile 
                245                 250                 255     


Leu Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln Val 
            260                 265                 270         


Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu Gln 
        275                 280                 285             


Ile Val Asp Lys 
    290         


<210>  4
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  4

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Val Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Leu Arg Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Ala Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Val Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp Thr 
    130                 135                 140                 


Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Val 
                165                 170                 175     


Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
        195                 200                 205             


Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe 
    210                 215                 220                 


Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro 
225                 230                 235                 240 


Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile 
                245                 250                 255     


Leu Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln Val 
            260                 265                 270         


Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu Gln 
        275                 280                 285             


Ile Val Asp Lys Pro Ser Pro Pro Gln Asp Ile Arg Ile Val Glu Thr 
    290                 295                 300                 


Trp Gly Phe Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Asp Gly 
305                 310                 315                 320 


Asn Thr Glu Ile Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr 
                325                 330                 335     


Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys Val 
            340                 345                 350         


Val Ser Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser 
        355                 360                 365             


His Asn Met Val Gly Ser Ser Asp Lys Ala Ala Ala Thr Lys Glu Pro 
    370                 375                 380                 


Val Phe Ile Pro Arg Pro 
385                 390 


<210>  5
<211>  501
<212>  PRT
<213>  Mus musculus

<400>  5

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Val Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Leu Arg Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Ala Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Val Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp Thr 
    130                 135                 140                 


Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Val 
                165                 170                 175     


Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
        195                 200                 205             


Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe 
    210                 215                 220                 


Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro 
225                 230                 235                 240 


Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile 
                245                 250                 255     


Leu Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln Val 
            260                 265                 270         


Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu Gln 
        275                 280                 285             


Ile Val Asp Lys Pro Ser Pro Pro Gln Asp Ile Arg Ile Val Glu Thr 
    290                 295                 300                 


Trp Gly Phe Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Asp Gly 
305                 310                 315                 320 


Asn Thr Glu Ile Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr 
                325                 330                 335     


Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys Val 
            340                 345                 350         


Val Ser Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser 
        355                 360                 365             


His Asn Met Val Gly Ser Ser Asp Lys Ala Ala Ala Thr Lys Glu Pro 
    370                 375                 380                 


Val Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu Pro Pro Lys Tyr Lys 
385                 390                 395                 400 


Ala Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr Gln Pro Leu Ala Asn 
                405                 410                 415     


Arg Ser Ile Ile Ala Gly Tyr Asn Ala Ile Leu Cys Cys Ala Val Arg 
            420                 425                 430         


Gly Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu 
        435                 440                 445             


Gly Glu Asp Ala Arg Phe Arg Met Phe Cys Lys Gln Gly Val Leu Thr 
    450                 455                 460                 


Leu Glu Ile Arg Lys Pro Cys Pro Tyr Asp Gly Gly Val Tyr Val Cys 
465                 470                 475                 480 


Arg Ala Thr Asn Leu Gln Gly Glu Ala Gln Cys Glu Cys Arg Leu Glu 
                485                 490                 495     


Val Arg Val Pro Gln 
            500     


<210>  6
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  6

Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys 
1               5                   10                  15      


Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg 
            20                  25                  30          


Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu 
        35                  40                  45              


Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala 
    50                  55                  60                  


Ala Arg Arg Thr His Ser Gly Thr Tyr Gln Val Thr Val Arg Ile Glu 
65                  70                  75                  80  


Asn Met Glu Asp Lys Ala Thr Leu Ile Leu Gln Ile Val Asp Lys Pro 
                85                  90                  95      


Ser Pro Pro Gln Asp Ile Arg Ile Val Glu Thr Trp Gly Phe Asn Val 
            100                 105                 110         


Ala Leu Glu Trp Lys Pro Pro Gln Asp Asp Gly Asn Thr Glu Ile Trp 
        115                 120                 125             


Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr 
    130                 135                 140                 


Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val Ser Glu Leu Ile 
145                 150                 155                 160 


Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser His Asn Met Val Gly 
                165                 170                 175     


Ser Ser Asp Lys Ala Ala Ala Thr Lys Glu Pro Val Phe Ile Pro Arg 
            180                 185                 190         


Pro Gly Ile Thr Tyr Glu Pro Pro Lys Tyr Lys Ala Leu Asp Phe Ser 
        195                 200                 205             


Glu Ala Pro Ser Phe Thr Gln Pro Leu Ala Asn Arg Ser Ile Ile Ala 
    210                 215                 220                 


Gly Tyr Asn Ala Ile Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro 
225                 230                 235                 240 


Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg 
                245                 250                 255     


Phe Arg Met Phe Cys Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys 
            260                 265                 270         


Pro Cys Pro Tyr Asp Gly Gly Val Tyr Val Cys Arg Ala Thr Asn Leu 
        275                 280                 285             


Gln Gly Glu Ala Gln Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
    290                 295                 300                 


<210>  7
<211>  207
<212>  PRT
<213>  Mus musculus

<400>  7

Pro Pro Gln Asp Ile Arg Ile Val Glu Thr Trp Gly Phe Asn Val Ala 
1               5                   10                  15      


Leu Glu Trp Lys Pro Pro Gln Asp Asp Gly Asn Thr Glu Ile Trp Gly 
            20                  25                  30          


Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr Val 
        35                  40                  45              


Leu Glu His Tyr Arg Arg Thr His Cys Val Val Ser Glu Leu Ile Ile 
    50                  55                  60                  


Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser His Asn Met Val Gly Ser 
65                  70                  75                  80  


Ser Asp Lys Ala Ala Ala Thr Lys Glu Pro Val Phe Ile Pro Arg Pro 
                85                  90                  95      


Gly Ile Thr Tyr Glu Pro Pro Lys Tyr Lys Ala Leu Asp Phe Ser Glu 
            100                 105                 110         


Ala Pro Ser Phe Thr Gln Pro Leu Ala Asn Arg Ser Ile Ile Ala Gly 
        115                 120                 125             


Tyr Asn Ala Ile Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro Lys 
    130                 135                 140                 


Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg Phe 
145                 150                 155                 160 


Arg Met Phe Cys Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys Pro 
                165                 170                 175     


Cys Pro Tyr Asp Gly Gly Val Tyr Val Cys Arg Ala Thr Asn Leu Gln 
            180                 185                 190         


Gly Glu Ala Gln Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
        195                 200                 205         


<210>  8
<211>  94
<212>  PRT
<213>  Mus musculus

<400>  8

Pro Ser Phe Thr Gln Pro Leu Ala Asn Arg Ser Ile Ile Ala Gly Tyr 
1               5                   10                  15      


Asn Ala Ile Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro Lys Ile 
            20                  25                  30          


Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg Phe Arg 
        35                  40                  45              


Met Phe Cys Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys Pro Cys 
    50                  55                  60                  


Pro Tyr Asp Gly Gly Val Tyr Val Cys Arg Ala Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Glu Ala Gln Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
                85                  90                  


<210>  9
<211>  1273
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro Arg 
1               5                   10                  15      


Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu Thr 
            20                  25                  30          


Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp Ile 
        35                  40                  45              


Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His Thr 
    50                  55                  60                  


Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala Val 
65                  70                  75                  80  


Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu Ala 
                85                  90                  95      


Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu Ala 
            100                 105                 110         


Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly Glu 
        115                 120                 125             


Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly Pro 
    130                 135                 140                 


Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg Pro 
145                 150                 155                 160 


Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala Arg 
                165                 170                 175     


Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe Lys 
            180                 185                 190         


Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln Leu 
        195                 200                 205             


His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu His 
    210                 215                 220                 


Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu Val 
225                 230                 235                 240 


Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val His 
                245                 250                 255     


Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg Arg 
            260                 265                 270         


Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu Asp 
        275                 280                 285             


Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser Phe 
    290                 295                 300                 


Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp Val 
305                 310                 315                 320 


Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile Ala 
                325                 330                 335     


Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys 
            340                 345                 350         


Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys Leu 
        355                 360                 365             


Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr Val 
    370                 375                 380                 


Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly Gln 
385                 390                 395                 400 


Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly Ala 
                405                 410                 415     


Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala Ala 
            420                 425                 430         


Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe Val 
        435                 440                 445             


Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu Val 
    450                 455                 460                 


Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu Gly 
465                 470                 475                 480 


Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu Glu 
                485                 490                 495     


Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu Ile 
            500                 505                 510         


Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys Thr 
        515                 520                 525             


Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys Leu 
    530                 535                 540                 


Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp Gln 
545                 550                 555                 560 


Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val Trp 
                565                 570                 575     


Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val Ser 
            580                 585                 590         


His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro Ala 
        595                 600                 605             


Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn Leu 
    610                 615                 620                 


Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro Arg 
625                 630                 635                 640 


Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro Asp 
                645                 650                 655     


Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro Ile 
            660                 665                 670         


Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr Gln 
        675                 680                 685             


Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp Thr 
    690                 695                 700                 


Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu Thr 
705                 710                 715                 720 


Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe Thr 
                725                 730                 735     


Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr Val 
            740                 745                 750         


Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val Ile 
        755                 760                 765             


Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu 
    770                 775                 780                 


Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln 
785                 790                 795                 800 


Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg 
                805                 810                 815     


Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala 
            820                 825                 830         


Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val 
        835                 840                 845             


Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met 
    850                 855                 860                 


Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val 
865                 870                 875                 880 


Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly 
                885                 890                 895     


Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys 
            900                 905                 910         


Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile 
        915                 920                 925             


Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg 
    930                 935                 940                 


Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro 
945                 950                 955                 960 


Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg 
                965                 970                 975     


His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu 
            980                 985                 990         


Leu Ile Pro Phe Gln Gly Lys Pro  Arg Pro Gln Val Thr  Trp Thr Lys 
        995                 1000                 1005             


Glu Gly  Gln Pro Leu Ala Gly  Glu Glu Val Ser Ile  Arg Asn Ser 
    1010                 1015                 1020             


Pro Thr  Asp Thr Ile Leu Phe  Ile Arg Ala Ala Arg  Arg Val His 
    1025                 1030                 1035             


Ser Gly  Thr Tyr Gln Val Thr  Val Arg Ile Glu Asn  Met Glu Asp 
    1040                 1045                 1050             


Lys Ala  Thr Leu Val Leu Gln  Val Val Asp Lys Pro  Ser Pro Pro 
    1055                 1060                 1065             


Gln Asp  Leu Arg Val Thr Asp  Ala Trp Gly Leu Asn  Val Ala Leu 
    1070                 1075                 1080             


Glu Trp  Lys Pro Pro Gln Asp  Val Gly Asn Thr Glu  Leu Trp Gly 
    1085                 1090                 1095             


Tyr Thr  Val Gln Lys Ala Asp  Lys Lys Thr Met Glu  Trp Phe Thr 
    1100                 1105                 1110             


Val Leu  Glu His Tyr Arg Arg  Thr His Cys Val Val  Pro Glu Leu 
    1115                 1120                 1125             


Ile Ile  Gly Asn Gly Tyr Tyr  Phe Arg Val Phe Ser  Gln Asn Met 
    1130                 1135                 1140             


Val Gly  Phe Ser Asp Arg Ala  Ala Thr Thr Lys Glu  Pro Val Phe 
    1145                 1150                 1155             


Ile Pro  Arg Pro Gly Ile Thr  Tyr Glu Pro Pro Asn  Tyr Lys Ala 
    1160                 1165                 1170             


Leu Asp  Phe Ser Glu Ala Pro  Ser Phe Thr Gln Pro  Leu Val Asn 
    1175                 1180                 1185             


Arg Ser  Val Ile Ala Gly Tyr  Thr Ala Met Leu Cys  Cys Ala Val 
    1190                 1195                 1200             


Arg Gly  Ser Pro Lys Pro Lys  Ile Ser Trp Phe Lys  Asn Gly Leu 
    1205                 1210                 1215             


Asp Leu  Gly Glu Asp Ala Arg  Phe Arg Met Phe Ser  Lys Gln Gly 
    1220                 1225                 1230             


Val Leu  Thr Leu Glu Ile Arg  Lys Pro Cys Pro Phe  Asp Gly Gly 
    1235                 1240                 1245             


Ile Tyr  Val Cys Arg Ala Thr  Asn Leu Gln Gly Glu  Ala Arg Cys 
    1250                 1255                 1260             


Glu Cys  Arg Leu Glu Val Arg  Val Pro Gln 
    1265                 1270             


<210>  10
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Ile Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Ile Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp Val 
    130                 135                 140                 


Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Met 
                165                 170                 175     


Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile 
        


<210>  11
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Ile Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Ile Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp Val 
    130                 135                 140                 


Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Met 
                165                 170                 175     


Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
        195                 200                 205             


Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe 
    210                 215                 220                 


Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro 
225                 230                 235                 240 


Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile 
                245                 250                 255     


Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val 
            260                 265                 270         


Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln 
        275                 280                 285             


Val Val Asp Lys 
    290         


<210>  12
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Ile Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Ile Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp Val 
    130                 135                 140                 


Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Met 
                165                 170                 175     


Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
        195                 200                 205             


Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe 
    210                 215                 220                 


Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro 
225                 230                 235                 240 


Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile 
                245                 250                 255     


Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val 
            260                 265                 270         


Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln 
        275                 280                 285             


Val Val Asp Lys Pro Ser Pro Pro Gln Asp Leu Arg Val Thr Asp Ala 
    290                 295                 300                 


Trp Gly Leu Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Val Gly 
305                 310                 315                 320 


Asn Thr Glu Leu Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr 
                325                 330                 335     


Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys Val 
            340                 345                 350         


Val Pro Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser 
        355                 360                 365             


Gln Asn Met Val Gly Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro 
    370                 375                 380                 


Val Phe Ile Pro Arg Pro 
385                 390 


<210>  13
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp Ser Cys Thr 
1               5                   10                  15      


Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro Ile Leu Gly 
            20                  25                  30          


Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp Met Arg Leu 
        35                  40                  45              


Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg Arg Met Ile 
    50                  55                  60                  


Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn Ala Ile Gly 
65                  70                  75                  80  


Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro Ile Gly Pro 
                85                  90                  95      


Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr Thr 
            100                 105                 110         


Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly Leu 
        115                 120                 125             


Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp Val 
    130                 135                 140                 


Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys Asp 
145                 150                 155                 160 


Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn Met 
                165                 170                 175     


Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val Gln 
            180                 185                 190         


Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln 
        195                 200                 205             


Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe 
    210                 215                 220                 


Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro 
225                 230                 235                 240 


Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile 
                245                 250                 255     


Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val 
            260                 265                 270         


Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln 
        275                 280                 285             


Val Val Asp Lys Pro Ser Pro Pro Gln Asp Leu Arg Val Thr Asp Ala 
    290                 295                 300                 


Trp Gly Leu Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Val Gly 
305                 310                 315                 320 


Asn Thr Glu Leu Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr 
                325                 330                 335     


Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys Val 
            340                 345                 350         


Val Pro Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser 
        355                 360                 365             


Gln Asn Met Val Gly Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro 
    370                 375                 380                 


Val Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu Pro Pro Asn Tyr Lys 
385                 390                 395                 400 


Ala Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr Gln Pro Leu Val Asn 
                405                 410                 415     


Arg Ser Val Ile Ala Gly Tyr Thr Ala Met Leu Cys Cys Ala Val Arg 
            420                 425                 430         


Gly Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu 
        435                 440                 445             


Gly Glu Asp Ala Arg Phe Arg Met Phe Ser Lys Gln Gly Val Leu Thr 
    450                 455                 460                 


Leu Glu Ile Arg Lys Pro Cys Pro Phe Asp Gly Gly Ile Tyr Val Cys 
465                 470                 475                 480 


Arg Ala Thr Asn Leu Gln Gly Glu Ala Arg Cys Glu Cys Arg Leu Glu 
                485                 490                 495     


Val Arg Val Pro Gln 
            500     


<210>  14
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys 
1               5                   10                  15      


Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg 
            20                  25                  30          


Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu 
        35                  40                  45              


Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala 
    50                  55                  60                  


Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val Thr Val Arg Ile Glu 
65                  70                  75                  80  


Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln Val Val Asp Lys Pro 
                85                  90                  95      


Ser Pro Pro Gln Asp Leu Arg Val Thr Asp Ala Trp Gly Leu Asn Val 
            100                 105                 110         


Ala Leu Glu Trp Lys Pro Pro Gln Asp Val Gly Asn Thr Glu Leu Trp 
        115                 120                 125             


Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr 
    130                 135                 140                 


Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val Pro Glu Leu Ile 
145                 150                 155                 160 


Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser Gln Asn Met Val Gly 
                165                 170                 175     


Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro Val Phe Ile Pro Arg 
            180                 185                 190         


Pro Gly Ile Thr Tyr Glu Pro Pro Asn Tyr Lys Ala Leu Asp Phe Ser 
        195                 200                 205             


Glu Ala Pro Ser Phe Thr Gln Pro Leu Val Asn Arg Ser Val Ile Ala 
    210                 215                 220                 


Gly Tyr Thr Ala Met Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro 
225                 230                 235                 240 


Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg 
                245                 250                 255     


Phe Arg Met Phe Ser Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys 
            260                 265                 270         


Pro Cys Pro Phe Asp Gly Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu 
        275                 280                 285             


Gln Gly Glu Ala Arg Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
    290                 295                 300                 


<210>  15
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Pro Gln Asp Leu Arg Val Thr Asp Ala Trp Gly Leu Asn Val Ala 
1               5                   10                  15      


Leu Glu Trp Lys Pro Pro Gln Asp Val Gly Asn Thr Glu Leu Trp Gly 
            20                  25                  30          


Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr Val 
        35                  40                  45              


Leu Glu His Tyr Arg Arg Thr His Cys Val Val Pro Glu Leu Ile Ile 
    50                  55                  60                  


Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser Gln Asn Met Val Gly Phe 
65                  70                  75                  80  


Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro Val Phe Ile Pro Arg Pro 
                85                  90                  95      


Gly Ile Thr Tyr Glu Pro Pro Asn Tyr Lys Ala Leu Asp Phe Ser Glu 
            100                 105                 110         


Ala Pro Ser Phe Thr Gln Pro Leu Val Asn Arg Ser Val Ile Ala Gly 
        115                 120                 125             


Tyr Thr Ala Met Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro Lys 
    130                 135                 140                 


Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg Phe 
145                 150                 155                 160 


Arg Met Phe Ser Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys Pro 
                165                 170                 175     


Cys Pro Phe Asp Gly Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu Gln 
            180                 185                 190         


Gly Glu Ala Arg Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
        195                 200                 205         


<210>  16
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Ser Phe Thr Gln Pro Leu Val Asn Arg Ser Val Ile Ala Gly Tyr 
1               5                   10                  15      


Thr Ala Met Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro Lys Ile 
            20                  25                  30          


Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg Phe Arg 
        35                  40                  45              


Met Phe Ser Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys Pro Cys 
    50                  55                  60                  


Pro Phe Asp Gly Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Glu Ala Arg Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
                85                  90                  


<210>  17
<211>  3831
<212>  DNA
<213>  Mus musculus

<400>  17
cctggtgtga ctgttctcaa gatgccggag ccagggaaga aaccagtgtc agccttcaac       60

aagaagccaa ggtcagcgga ggtgaccgct ggcagtgctg ccgtgttcga ggctgagacg      120

gagcggtcag gcgtgaaggt gcggtggcag cgggatggca gcgacatcac cgccaatgac      180

aagtatggtt tggcagcaga gggcaagcga cacacactga cagtgcggga tgcgagccct      240

gatgaccagg gttcctacgc ggtcattgca ggctcctcaa aggtcaagtt tgacctcaag      300

gtcacagagc cagcccctcc agagaaggca gaatctgaag ttgctccagg agcccccaaa      360

gaagtccctg ctccagccac tgagttggaa gaaagtgtct caagtcctga agggtcagtc      420

tcggtaaccc aggatggctc agctgcagag catcagggag cccctgatga ccctattggc      480

ctctttctga tgcgaccaca ggatggtgag gtgaccgtgg gcggcagcat tgtcttctca      540

gcccgagtgg ctggggccag cctcctgaaa ccgcctgtgg tcaagtggtt caagggcaag      600

tgggtggacc tgagcagcaa agtgggccag cacctgcagc tgcatgacag ctatgacaga      660

gccagcaagg tctacttgtt tgagttgcac atcacagatg ctcagaccac ttctgctggg      720

ggctaccgct gtgaggtgtc taccaaggac aaatttgaca gctgtaactt caacctcact      780

gtccatgagg ccattggttc tggagacctg gacctcagat cagctttccg acgcacgagc      840

ctggcgggag caggtcggag aaccagtgac agccatgaag atgctgggac tctggacttt      900

agttccctgc tgaagaagag agacagtttc cggagggact caaagctgga ggcacctgct      960

gaagaagacg tgtgggagat cctgagacag gcaccgccgt cagaatatga gcgcatcgcc     1020

ttccagcacg gagtcacaga ccttcgaggc atgctgaaga ggctcaaggg catgaagcag     1080

gatgaaaaga agagcacagc ctttcagaag aagctggagc ctgcctacca ggtaaacaag     1140

ggccacaaga ttcggcttac tgtggaactg gctgatccgg acgccgaagt caagtggctt     1200

aagaatggac aggagatcca gatgagtggc agcaagtaca tcttcgagtc cgtcggtgcc     1260

aagcgcaccc tgaccatcag ccagtgctca ctggctgacg acgcagccta ccagtgtgtg     1320

gtggggggcg agaagtgcag cacggagctc tttgtcaaag agcccccggt gctgatcact     1380

cggtccctgg aagaccagct ggtgatggtg ggtcagcggg tggagtttga gtgtgaggtc     1440

tcagaagaag gggcccaagt caaatggctg aaggatgggg ttgagctgac acgtgaggag     1500

accttcaaat accggttcaa gaaagatggg cggaaacacc acttgatcat caatgaagca     1560

accctggagg atgcaggaca ctatgcagta cgcacaagtg gaggccagtc actggctgag     1620

ctcattgtgc aagagaagaa gttggaggta taccaaagca tcgcggacct ggcagtggga     1680

gccaaggacc aggctgtgtt taagtgtgag gtttcagatg agaatgtacg cggcgtgtgg     1740

ctgaagaatg ggaaggaact ggtgcctgac aaccgcataa aggtgtccca tataggccgg     1800

gtccacaaac tgaccattga cgatgtcaca cctgctgatg aggctgacta cagctttgtc     1860

cctgaagggt ttgcctgcaa cctgtctgcc aagctccact tcatggaggt caagattgac     1920

tttgtgccta ggcaggaacc tcccaagatc cacttggatt gtcccggcag cacaccagac     1980

accattgtgg ttgttgctgg gaacaagtta cgcctggatg tccctatttc tggagaccct     2040

gctcccactg tggtctggca gaagactgta acacagggga agaaggcctc aactgggcca     2100

caccctgatg ccccagaaga tgctggtgct gatgaggagt gggtgtttga taagaagctg     2160

ttgtgtgaga ctgagggccg ggtccgggtg gagaccacca aagaccgcag cgtctttaca     2220

gtcgaagggg cagagaagga agatgaaggt gtctacacag tcacagtaaa gaaccccgtg     2280

ggcgaggacc aggtcaacct cacagtcaag gtcatcgatg tcccagatgc tcctgcggcc     2340

cctaagatca gcaacgtggg cgaggactcc tgcactgtgc agtgggaacc gcctgcctat     2400

gatggcgggc agccggtcct gggatacatc ctggagcgca agaagaaaaa gagctacagg     2460

tggatgaggc tcaactttga tctgctgcgg gagctgagcc acgaggcgag gcgcatgatc     2520

gagggtgtag cctatgagat gcgagtctac gcagtcaatg ccgtgggaat gtccaggccc     2580

agccctgcct ctcagccctt catgcctatt gggccccctg gcgaaccaac ccacttggct     2640

gtggaggatg tgtcagacac cactgtctca ctcaagtggc ggcccccaga gcgcgtgggg     2700

gccggtggcc tggacggata cagcgtggag tactgccagg agggatgctc cgagtggaca     2760

cctgctctgc aggggctgac agagcgcaca tcgatgctgg tgaaggacct acccactggg     2820

gcacggctgc tgttccgagt acgggcacac aatgtggcag gtcctggagg ccctatcgtc     2880

accaaggagc ctgtgacagt gcaggagata ctgcaacgac cacggctcca actgcccaga     2940

cacctgcgcc agaccatcca gaagaaagtt ggggagcctg tgaacctcct catccctttc     3000

cagggcaaac cccggcctca ggtgacctgg accaaagagg ggcagcccct ggcaggtgag     3060

gaggtgagca tccggaacag ccccacagac acgatcttgt tcatccgagc tgcccgccgc     3120

acccactcgg gcacctacca ggtgacagtt cgcattgaga acatggagga caaggcaacg     3180

ctgatcctgc agattgtgga caagccaagt cctccccagg atatccggat cgttgagact     3240

tggggtttca atgtggctct ggagtggaag ccaccccaag atgatggcaa tacagagatc     3300

tggggttata ctgtacagaa agctgacaag aagaccatgg agtggttcac ggttttggaa     3360

cactaccgac gcactcactg tgtggtatca gagcttatca ttggcaatgg ctactacttc     3420

cgggtcttca gccataacat ggtgggttcc agtgacaaag ctgccgccac caaggagcca     3480

gtctttattc caagaccagg catcacatat gagccaccca aatacaaggc cctggacttc     3540

tctgaggccc caagcttcac ccagcccttg gcaaatcgct ccatcattgc aggctataat     3600

gccatcctct gctgtgctgt ccgaggtagt cctaagccca agatttcctg gttcaagaat     3660

ggcctggatc tgggagaaga tgctcgcttc cgcatgttct gcaagcaggg agtattgacc     3720

ctggagatca ggaaaccctg cccctatgat ggtggtgtct atgtctgcag ggccaccaac     3780

ttgcagggcg aggcacagtg tgagtgccgc ctggaggtgc gagttcctca g              3831


<210>  18
<211>  582
<212>  DNA
<213>  Mus musculus

<400>  18
gctcctgcgg cccctaagat cagcaacgtg ggcgaggact cctgcactgt gcagtgggaa       60

ccgcctgcct atgatggcgg gcagccggtc ctgggataca tcctggagcg caagaagaaa      120

aagagctaca ggtggatgag gctcaacttt gatctgctgc gggagctgag ccacgaggcg      180

aggcgcatga tcgagggtgt agcctatgag atgcgagtct acgcagtcaa tgccgtggga      240

atgtccaggc ccagccctgc ctctcagccc ttcatgccta ttgggccccc tggcgaacca      300

acccacttgg ctgtggagga tgtgtcagac accactgtct cactcaagtg gcggccccca      360

gagcgcgtgg gggccggtgg cctggacgga tacagcgtgg agtactgcca ggagggatgc      420

tccgagtgga cacctgctct gcaggggctg acagagcgca catcgatgct ggtgaaggac      480

ctacccactg gggcacggct gctgttccga gtacgggcac acaatgtggc aggtcctgga      540

ggccctatcg tcaccaagga gcctgtgaca gtgcaggaga ta                         582


<210>  19
<211>  876
<212>  DNA
<213>  Mus musculus

<400>  19
gctcctgcgg cccctaagat cagcaacgtg ggcgaggact cctgcactgt gcagtgggaa       60

ccgcctgcct atgatggcgg gcagccggtc ctgggataca tcctggagcg caagaagaaa      120

aagagctaca ggtggatgag gctcaacttt gatctgctgc gggagctgag ccacgaggcg      180

aggcgcatga tcgagggtgt agcctatgag atgcgagtct acgcagtcaa tgccgtggga      240

atgtccaggc ccagccctgc ctctcagccc ttcatgccta ttgggccccc tggcgaacca      300

acccacttgg ctgtggagga tgtgtcagac accactgtct cactcaagtg gcggccccca      360

gagcgcgtgg gggccggtgg cctggacgga tacagcgtgg agtactgcca ggagggatgc      420

tccgagtgga cacctgctct gcaggggctg acagagcgca catcgatgct ggtgaaggac      480

ctacccactg gggcacggct gctgttccga gtacgggcac acaatgtggc aggtcctgga      540

ggccctatcg tcaccaagga gcctgtgaca gtgcaggaga tactgcaacg accacggctc      600

caactgccca gacacctgcg ccagaccatc cagaagaaag ttggggagcc tgtgaacctc      660

ctcatccctt tccagggcaa accccggcct caggtgacct ggaccaaaga ggggcagccc      720

ctggcaggtg aggaggtgag catccggaac agccccacag acacgatctt gttcatccga      780

gctgcccgcc gcacccactc gggcacctac caggtgacag ttcgcattga gaacatggag      840

gacaaggcaa cgctgatcct gcagattgtg gacaag                                876


<210>  20
<211>  1170
<212>  DNA
<213>  Mus musculus

<400>  20
gctcctgcgg cccctaagat cagcaacgtg ggcgaggact cctgcactgt gcagtgggaa       60

ccgcctgcct atgatggcgg gcagccggtc ctgggataca tcctggagcg caagaagaaa      120

aagagctaca ggtggatgag gctcaacttt gatctgctgc gggagctgag ccacgaggcg      180

aggcgcatga tcgagggtgt agcctatgag atgcgagtct acgcagtcaa tgccgtggga      240

atgtccaggc ccagccctgc ctctcagccc ttcatgccta ttgggccccc tggcgaacca      300

acccacttgg ctgtggagga tgtgtcagac accactgtct cactcaagtg gcggccccca      360

gagcgcgtgg gggccggtgg cctggacgga tacagcgtgg agtactgcca ggagggatgc      420

tccgagtgga cacctgctct gcaggggctg acagagcgca catcgatgct ggtgaaggac      480

ctacccactg gggcacggct gctgttccga gtacgggcac acaatgtggc aggtcctgga      540

ggccctatcg tcaccaagga gcctgtgaca gtgcaggaga tactgcaacg accacggctc      600

caactgccca gacacctgcg ccagaccatc cagaagaaag ttggggagcc tgtgaacctc      660

ctcatccctt tccagggcaa accccggcct caggtgacct ggaccaaaga ggggcagccc      720

ctggcaggtg aggaggtgag catccggaac agccccacag acacgatctt gttcatccga      780

gctgcccgcc gcacccactc gggcacctac caggtgacag ttcgcattga gaacatggag      840

gacaaggcaa cgctgatcct gcagattgtg gacaagccaa gtcctcccca ggatatccgg      900

atcgttgaga cttggggttt caatgtggct ctggagtgga agccacccca agatgatggc      960

aatacagaga tctggggtta tactgtacag aaagctgaca agaagaccat ggagtggttc     1020

acggttttgg aacactaccg acgcactcac tgtgtggtat cagagcttat cattggcaat     1080

ggctactact tccgggtctt cagccataac atggtgggtt ccagtgacaa agctgccgcc     1140

accaaggagc cagtctttat tccaagacca                                      1170


<210>  21
<211>  1503
<212>  DNA
<213>  Mus musculus

<400>  21
gctcctgcgg cccctaagat cagcaacgtg ggcgaggact cctgcactgt gcagtgggaa       60

ccgcctgcct atgatggcgg gcagccggtc ctgggataca tcctggagcg caagaagaaa      120

aagagctaca ggtggatgag gctcaacttt gatctgctgc gggagctgag ccacgaggcg      180

aggcgcatga tcgagggtgt agcctatgag atgcgagtct acgcagtcaa tgccgtggga      240

atgtccaggc ccagccctgc ctctcagccc ttcatgccta ttgggccccc tggcgaacca      300

acccacttgg ctgtggagga tgtgtcagac accactgtct cactcaagtg gcggccccca      360

gagcgcgtgg gggccggtgg cctggacgga tacagcgtgg agtactgcca ggagggatgc      420

tccgagtgga cacctgctct gcaggggctg acagagcgca catcgatgct ggtgaaggac      480

ctacccactg gggcacggct gctgttccga gtacgggcac acaatgtggc aggtcctgga      540

ggccctatcg tcaccaagga gcctgtgaca gtgcaggaga tactgcaacg accacggctc      600

caactgccca gacacctgcg ccagaccatc cagaagaaag ttggggagcc tgtgaacctc      660

ctcatccctt tccagggcaa accccggcct caggtgacct ggaccaaaga ggggcagccc      720

ctggcaggtg aggaggtgag catccggaac agccccacag acacgatctt gttcatccga      780

gctgcccgcc gcacccactc gggcacctac caggtgacag ttcgcattga gaacatggag      840

gacaaggcaa cgctgatcct gcagattgtg gacaagccaa gtcctcccca ggatatccgg      900

atcgttgaga cttggggttt caatgtggct ctggagtgga agccacccca agatgatggc      960

aatacagaga tctggggtta tactgtacag aaagctgaca agaagaccat ggagtggttc     1020

acggttttgg aacactaccg acgcactcac tgtgtggtat cagagcttat cattggcaat     1080

ggctactact tccgggtctt cagccataac atggtgggtt ccagtgacaa agctgccgcc     1140

accaaggagc cagtctttat tccaagacca ggcatcacat atgagccacc caaatacaag     1200

gccctggact tctctgaggc cccaagcttc acccagccct tggcaaatcg ctccatcatt     1260

gcaggctata atgccatcct ctgctgtgct gtccgaggta gtcctaagcc caagatttcc     1320

tggttcaaga atggcctgga tctgggagaa gatgctcgct tccgcatgtt ctgcaagcag     1380

ggagtattga ccctggagat caggaaaccc tgcccctatg atggtggtgt ctatgtctgc     1440

agggccacca acttgcaggg cgaggcacag tgtgagtgcc gcctggaggt gcgagttcct     1500

cag                                                                   1503


<210>  22
<211>  912
<212>  DNA
<213>  Mus musculus

<400>  22
ccacggctcc aactgcccag acacctgcgc cagaccatcc agaagaaagt tggggagcct       60

gtgaacctcc tcatcccttt ccagggcaaa ccccggcctc aggtgacctg gaccaaagag      120

gggcagcccc tggcaggtga ggaggtgagc atccggaaca gccccacaga cacgatcttg      180

ttcatccgag ctgcccgccg cacccactcg ggcacctacc aggtgacagt tcgcattgag      240

aacatggagg acaaggcaac gctgatcctg cagattgtgg acaagccaag tcctccccag      300

gatatccgga tcgttgagac ttggggtttc aatgtggctc tggagtggaa gccaccccaa      360

gatgatggca atacagagat ctggggttat actgtacaga aagctgacaa gaagaccatg      420

gagtggttca cggttttgga acactaccga cgcactcact gtgtggtatc agagcttatc      480

attggcaatg gctactactt ccgggtcttc agccataaca tggtgggttc cagtgacaaa      540

gctgccgcca ccaaggagcc agtctttatt ccaagaccag gcatcacata tgagccaccc      600

aaatacaagg ccctggactt ctctgaggcc ccaagcttca cccagccctt ggcaaatcgc      660

tccatcattg caggctataa tgccatcctc tgctgtgctg tccgaggtag tcctaagccc      720

aagatttcct ggttcaagaa tggcctggat ctgggagaag atgctcgctt ccgcatgttc      780

tgcaagcagg gagtattgac cctggagatc aggaaaccct gcccctatga tggtggtgtc      840

tatgtctgca gggccaccaa cttgcagggc gaggcacagt gtgagtgccg cctggaggtg      900

cgagttcctc ag                                                          912


<210>  23
<211>  621
<212>  DNA
<213>  Mus musculus

<400>  23
cctccccagg atatccggat cgttgagact tggggtttca atgtggctct ggagtggaag       60

ccaccccaag atgatggcaa tacagagatc tggggttata ctgtacagaa agctgacaag      120

aagaccatgg agtggttcac ggttttggaa cactaccgac gcactcactg tgtggtatca      180

gagcttatca ttggcaatgg ctactacttc cgggtcttca gccataacat ggtgggttcc      240

agtgacaaag ctgccgccac caaggagcca gtctttattc caagaccagg catcacatat      300

gagccaccca aatacaaggc cctggacttc tctgaggccc caagcttcac ccagcccttg      360

gcaaatcgct ccatcattgc aggctataat gccatcctct gctgtgctgt ccgaggtagt      420

cctaagccca agatttcctg gttcaagaat ggcctggatc tgggagaaga tgctcgcttc      480

cgcatgttct gcaagcaggg agtattgacc ctggagatca ggaaaccctg cccctatgat      540

ggtggtgtct atgtctgcag ggccaccaac ttgcagggcg aggcacagtg tgagtgccgc      600

ctggaggtgc gagttcctca g                                                621


<210>  24
<211>  282
<212>  DNA
<213>  Mus musculus

<400>  24
ccaagcttca cccagccctt ggcaaatcgc tccatcattg caggctataa tgccatcctc       60

tgctgtgctg tccgaggtag tcctaagccc aagatttcct ggttcaagaa tggcctggat      120

ctgggagaag atgctcgctt ccgcatgttc tgcaagcagg gagtattgac cctggagatc      180

aggaaaccct gcccctatga tggtggtgtc tatgtctgca gggccaccaa cttgcagggc      240

gaggcacagt gtgagtgccg cctggaggtg cgagttcctc ag                         282


<210>  25
<211>  3819
<212>  DNA
<213>  Homo sapiens

<400>  25
cctgagccgg ggaagaagcc agtctcagct tttagcaaga agccacggtc agtggaagtg       60

gccgcaggca gccctgccgt gttcgaggcc gagacagagc gggcaggagt gaaggtgcgc      120

tggcagcgcg gaggcagtga catcagcgcc agcaacaagt acggcctggc cacagagggc      180

acacggcata cgctgacagt gcgggaagtg ggccctgccg accagggatc ttacgcagtc      240

attgctggct cctccaaggt caagttcgac ctcaaggtca tagaggcaga gaaggcagag      300

cccatgctgg cccctgcccc tgcccctgct gaggccactg gagcccctgg agaagccccg      360

gccccagccg ctgagctggg agaaagtgcc ccaagtccca aagggtcaag ctcagcagct      420

ctcaatggtc ctacccctgg agcccccgat gaccccattg gcctcttcgt gatgcggcca      480

caggatggcg aggtgaccgt gggtggcagc atcaccttct cagcccgcgt ggccggcgcc      540

agcctcctga agccgcctgt ggtcaagtgg ttcaagggca aatgggtgga cctgagcagc      600

aaggtgggcc agcacctgca gctgcacgac agctacgacc gcgccagcaa ggtctatctg      660

ttcgagctgc acatcaccga tgcccagcct gccttcactg gcagctaccg ctgtgaggtg      720

tccaccaagg acaaatttga ctgctccaac ttcaatctca ctgtccacga ggccatgggc      780

accggagacc tggacctcct atcagccttc cgccgcacga gcctggctgg aggtggtcgg      840

cggatcagtg atagccatga ggacactggg attctggact tcagctcact gctgaaaaag      900

agagacagtt tccggacccc gagggactcg aagctggagg caccagcaga ggaggacgtg      960

tgggagatcc tacggcaggc acccccatct gagtacgagc gcatcgcctt ccagtacggc     1020

gtcactgacc tgcgcggcat gctaaagagg ctcaagggca tgaggcgcga tgagaagaag     1080

agcacagcct ttcagaagaa gctggagccg gcctaccagg tgagcaaagg ccacaagatc     1140

cggctgaccg tggaactggc tgaccatgac gctgaggtca aatggctcaa gaatggccag     1200

gagatccaga tgagcggcag caagtacatc tttgagtcca tcggtgccaa gcgtaccctg     1260

accatcagcc agtgctcatt ggcggacgac gcagcctacc agtgcgtggt gggtggcgag     1320

aagtgtagca cggagctctt tgtgaaagag ccccctgtgc tcatcacgcg ccccttggag     1380

gaccagctgg tgatggtggg gcagcgggtg gagtttgagt gtgaagtatc ggaggagggg     1440

gcgcaagtca aatggctgaa ggacggggtg gagctgaccc gggaggagac cttcaaatac     1500

cggttcaaga aggacgggca gagacaccac ctgatcatca acgaggccat gctggaggac     1560

gcggggcact atgcactgtg cactagcggg ggccaggcgc tggctgagct cattgtgcag     1620

gaaaagaagc tggaggtgta ccagagcatc gcagacctga tggtgggcgc aaaggaccag     1680

gcggtgttca aatgtgaggt ctcagatgag aatgttcggg gtgtgtggct gaagaatggg     1740

aaggagctgg tgcccgacag ccgcataaag gtgtcccaca tcgggcgggt ccacaaactg     1800

accattgacg acgtcacacc tgccgacgag gctgactaca gctttgtgcc cgagggcttc     1860

gcctgcaacc tgtcagccaa gctccacttc atggaggtca agattgactt cgtacccagg     1920

caggaacctc ccaagatcca cctggactgc ccaggccgca taccagacac cattgtggtt     1980

gtagctggaa ataagctacg tctggacgtc cctatctctg gggaccctgc tcccactgtg     2040

atctggcaga aggctatcac gcaggggaat aaggccccag ccaggccagc cccagatgcc     2100

ccagaggaca caggtgacag cgatgagtgg gtgtttgaca agaagctgct gtgtgagacc     2160

gagggccggg tccgcgtgga gaccaccaag gaccgcagca tcttcacggt cgagggggca     2220

gagaaggaag atgagggcgt ctacacggtc acagtgaaga accctgtggg cgaggaccag     2280

gtcaacctca cagtcaaggt catcgacgtg ccagacgcac ctgcggcccc caagatcagc     2340

aacgtgggag aggactcctg cacagtacag tgggagccgc ctgcctacga tggcgggcag     2400

cccatcctgg gctacatcct ggagcgcaag aagaagaaga gctaccggtg gatgcggctg     2460

aacttcgacc tgattcagga gctgagtcat gaagcgcggc gcatgatcga gggcgtggtg     2520

tacgagatgc gcgtctacgc ggtcaacgcc atcggcatgt ccaggcccag ccctgcctcc     2580

cagcccttca tgcctatcgg tccccccagc gaacccaccc acctggcagt agaggacgtc     2640

tctgacacca cggtctccct caagtggcgg cccccagagc gcgtgggagc aggaggcctg     2700

gatggctaca gcgtggagta ctgcccagag ggctgctcag agtgggtggc tgccctgcag     2760

gggctgacag agcacacatc gatactggtg aaggacctgc ccacgggggc ccggctgctt     2820

ttccgagtgc gggcacacaa tatggcaggg cctggagccc ctgttaccac cacggagccg     2880

gtgacagtgc aggagatcct gcaacggcca cggcttcagc tgcccaggca cctgcgccag     2940

accattcaga agaaggtcgg ggagcctgtg aaccttctca tccctttcca gggcaagccc     3000

cggcctcagg tgacctggac caaagagggg cagcccctgg caggcgagga ggtgagcatc     3060

cgcaacagcc ccacagacac catcctgttc atccgggccg ctcgccgcgt gcattcaggc     3120

acttaccagg tgacggtgcg cattgagaac atggaggaca aggccacgct ggtgctgcag     3180

gttgttgaca agccaagtcc tccccaggat ctccgggtga ctgacgcctg gggtcttaat     3240

gtggctctgg agtggaagcc accccaggat gtcggcaaca cggagctctg ggggtacaca     3300

gtgcagaaag ccgacaagaa gaccatggag tggttcaccg tcttggagca ttaccgccgc     3360

acccactgcg tggtgccaga gctcatcatt ggcaatggct actacttccg cgtcttcagc     3420

cagaatatgg ttggctttag tgacagagcg gccaccacca aggagcccgt ctttatcccc     3480

agaccaggca tcacctatga gccacccaac tataaggccc tggacttctc cgaggcccca     3540

agcttcaccc agcccctggt gaaccgctcg gtcatcgcgg gctacactgc tatgctctgc     3600

tgtgctgtcc ggggtagccc caagcccaag atttcctggt tcaagaatgg cctggacctg     3660

ggagaagacg cccgcttccg catgttcagc aagcagggag tgttgactct ggagattaga     3720

aagccctgcc cctttgacgg gggcatctat gtctgcaggg ccaccaactt acagggcgag     3780

gcacggtgtg agtgccgcct ggaggtgcga gtgcctcag                            3819


<210>  26
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  26
gcacctgcgg cccccaagat cagcaacgtg ggagaggact cctgcacagt acagtgggag       60

ccgcctgcct acgatggcgg gcagcccatc ctgggctaca tcctggagcg caagaagaag      120

aagagctacc ggtggatgcg gctgaacttc gacctgattc aggagctgag tcatgaagcg      180

cggcgcatga tcgagggcgt ggtgtacgag atgcgcgtct acgcggtcaa cgccatcggc      240

atgtccaggc ccagccctgc ctcccagccc ttcatgccta tcggtccccc cagcgaaccc      300

acccacctgg cagtagagga cgtctctgac accacggtct ccctcaagtg gcggccccca      360

gagcgcgtgg gagcaggagg cctggatggc tacagcgtgg agtactgccc agagggctgc      420

tcagagtggg tggctgccct gcaggggctg acagagcaca catcgatact ggtgaaggac      480

ctgcccacgg gggcccggct gcttttccga gtgcgggcac acaatatggc agggcctgga      540

gcccctgtta ccaccacgga gccggtgaca gtgcaggaga tc                         582


<210>  27
<211>  876
<212>  DNA
<213>  Homo sapiens

<400>  27
gcacctgcgg cccccaagat cagcaacgtg ggagaggact cctgcacagt acagtgggag       60

ccgcctgcct acgatggcgg gcagcccatc ctgggctaca tcctggagcg caagaagaag      120

aagagctacc ggtggatgcg gctgaacttc gacctgattc aggagctgag tcatgaagcg      180

cggcgcatga tcgagggcgt ggtgtacgag atgcgcgtct acgcggtcaa cgccatcggc      240

atgtccaggc ccagccctgc ctcccagccc ttcatgccta tcggtccccc cagcgaaccc      300

acccacctgg cagtagagga cgtctctgac accacggtct ccctcaagtg gcggccccca      360

gagcgcgtgg gagcaggagg cctggatggc tacagcgtgg agtactgccc agagggctgc      420

tcagagtggg tggctgccct gcaggggctg acagagcaca catcgatact ggtgaaggac      480

ctgcccacgg gggcccggct gcttttccga gtgcgggcac acaatatggc agggcctgga      540

gcccctgtta ccaccacgga gccggtgaca gtgcaggaga tcctgcaacg gccacggctt      600

cagctgccca ggcacctgcg ccagaccatt cagaagaagg tcggggagcc tgtgaacctt      660

ctcatccctt tccagggcaa gccccggcct caggtgacct ggaccaaaga ggggcagccc      720

ctggcaggcg aggaggtgag catccgcaac agccccacag acaccatcct gttcatccgg      780

gccgctcgcc gcgtgcattc aggcacttac caggtgacgg tgcgcattga gaacatggag      840

gacaaggcca cgctggtgct gcaggttgtt gacaag                                876


<210>  28
<211>  1170
<212>  DNA
<213>  Homo sapiens

<400>  28
gcacctgcgg cccccaagat cagcaacgtg ggagaggact cctgcacagt acagtgggag       60

ccgcctgcct acgatggcgg gcagcccatc ctgggctaca tcctggagcg caagaagaag      120

aagagctacc ggtggatgcg gctgaacttc gacctgattc aggagctgag tcatgaagcg      180

cggcgcatga tcgagggcgt ggtgtacgag atgcgcgtct acgcggtcaa cgccatcggc      240

atgtccaggc ccagccctgc ctcccagccc ttcatgccta tcggtccccc cagcgaaccc      300

acccacctgg cagtagagga cgtctctgac accacggtct ccctcaagtg gcggccccca      360

gagcgcgtgg gagcaggagg cctggatggc tacagcgtgg agtactgccc agagggctgc      420

tcagagtggg tggctgccct gcaggggctg acagagcaca catcgatact ggtgaaggac      480

ctgcccacgg gggcccggct gcttttccga gtgcgggcac acaatatggc agggcctgga      540

gcccctgtta ccaccacgga gccggtgaca gtgcaggaga tcctgcaacg gccacggctt      600

cagctgccca ggcacctgcg ccagaccatt cagaagaagg tcggggagcc tgtgaacctt      660

ctcatccctt tccagggcaa gccccggcct caggtgacct ggaccaaaga ggggcagccc      720

ctggcaggcg aggaggtgag catccgcaac agccccacag acaccatcct gttcatccgg      780

gccgctcgcc gcgtgcattc aggcacttac caggtgacgg tgcgcattga gaacatggag      840

gacaaggcca cgctggtgct gcaggttgtt gacaagccaa gtcctcccca ggatctccgg      900

gtgactgacg cctggggtct taatgtggct ctggagtgga agccacccca ggatgtcggc      960

aacacggagc tctgggggta cacagtgcag aaagccgaca agaagaccat ggagtggttc     1020

accgtcttgg agcattaccg ccgcacccac tgcgtggtgc cagagctcat cattggcaat     1080

ggctactact tccgcgtctt cagccagaat atggttggct ttagtgacag agcggccacc     1140

accaaggagc ccgtctttat ccccagacca                                      1170


<210>  29
<211>  1503
<212>  DNA
<213>  Homo sapiens

<400>  29
gcacctgcgg cccccaagat cagcaacgtg ggagaggact cctgcacagt acagtgggag       60

ccgcctgcct acgatggcgg gcagcccatc ctgggctaca tcctggagcg caagaagaag      120

aagagctacc ggtggatgcg gctgaacttc gacctgattc aggagctgag tcatgaagcg      180

cggcgcatga tcgagggcgt ggtgtacgag atgcgcgtct acgcggtcaa cgccatcggc      240

atgtccaggc ccagccctgc ctcccagccc ttcatgccta tcggtccccc cagcgaaccc      300

acccacctgg cagtagagga cgtctctgac accacggtct ccctcaagtg gcggccccca      360

gagcgcgtgg gagcaggagg cctggatggc tacagcgtgg agtactgccc agagggctgc      420

tcagagtggg tggctgccct gcaggggctg acagagcaca catcgatact ggtgaaggac      480

ctgcccacgg gggcccggct gcttttccga gtgcgggcac acaatatggc agggcctgga      540

gcccctgtta ccaccacgga gccggtgaca gtgcaggaga tcctgcaacg gccacggctt      600

cagctgccca ggcacctgcg ccagaccatt cagaagaagg tcggggagcc tgtgaacctt      660

ctcatccctt tccagggcaa gccccggcct caggtgacct ggaccaaaga ggggcagccc      720

ctggcaggcg aggaggtgag catccgcaac agccccacag acaccatcct gttcatccgg      780

gccgctcgcc gcgtgcattc aggcacttac caggtgacgg tgcgcattga gaacatggag      840

gacaaggcca cgctggtgct gcaggttgtt gacaagccaa gtcctcccca ggatctccgg      900

gtgactgacg cctggggtct taatgtggct ctggagtgga agccacccca ggatgtcggc      960

aacacggagc tctgggggta cacagtgcag aaagccgaca agaagaccat ggagtggttc     1020

accgtcttgg agcattaccg ccgcacccac tgcgtggtgc cagagctcat cattggcaat     1080

ggctactact tccgcgtctt cagccagaat atggttggct ttagtgacag agcggccacc     1140

accaaggagc ccgtctttat ccccagacca ggcatcacct atgagccacc caactataag     1200

gccctggact tctccgaggc cccaagcttc acccagcccc tggtgaaccg ctcggtcatc     1260

gcgggctaca ctgctatgct ctgctgtgct gtccggggta gccccaagcc caagatttcc     1320

tggttcaaga atggcctgga cctgggagaa gacgcccgct tccgcatgtt cagcaagcag     1380

ggagtgttga ctctggagat tagaaagccc tgcccctttg acgggggcat ctatgtctgc     1440

agggccacca acttacaggg cgaggcacgg tgtgagtgcc gcctggaggt gcgagtgcct     1500

cag                                                                   1503


<210>  30
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  30
ccacggcttc agctgcccag gcacctgcgc cagaccattc agaagaaggt cggggagcct       60

gtgaaccttc tcatcccttt ccagggcaag ccccggcctc aggtgacctg gaccaaagag      120

gggcagcccc tggcaggcga ggaggtgagc atccgcaaca gccccacaga caccatcctg      180

ttcatccggg ccgctcgccg cgtgcattca ggcacttacc aggtgacggt gcgcattgag      240

aacatggagg acaaggccac gctggtgctg caggttgttg acaagccaag tcctccccag      300

gatctccggg tgactgacgc ctggggtctt aatgtggctc tggagtggaa gccaccccag      360

gatgtcggca acacggagct ctgggggtac acagtgcaga aagccgacaa gaagaccatg      420

gagtggttca ccgtcttgga gcattaccgc cgcacccact gcgtggtgcc agagctcatc      480

attggcaatg gctactactt ccgcgtcttc agccagaata tggttggctt tagtgacaga      540

gcggccacca ccaaggagcc cgtctttatc cccagaccag gcatcaccta tgagccaccc      600

aactataagg ccctggactt ctccgaggcc ccaagcttca cccagcccct ggtgaaccgc      660

tcggtcatcg cgggctacac tgctatgctc tgctgtgctg tccggggtag ccccaagccc      720

aagatttcct ggttcaagaa tggcctggac ctgggagaag acgcccgctt ccgcatgttc      780

agcaagcagg gagtgttgac tctggagatt agaaagccct gcccctttga cgggggcatc      840

tatgtctgca gggccaccaa cttacagggc gaggcacggt gtgagtgccg cctggaggtg      900

cgagtgcctc ag                                                          912


<210>  31
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  31
cctccccagg atctccgggt gactgacgcc tggggtctta atgtggctct ggagtggaag       60

ccaccccagg atgtcggcaa cacggagctc tgggggtaca cagtgcagaa agccgacaag      120

aagaccatgg agtggttcac cgtcttggag cattaccgcc gcacccactg cgtggtgcca      180

gagctcatca ttggcaatgg ctactacttc cgcgtcttca gccagaatat ggttggcttt      240

agtgacagag cggccaccac caaggagccc gtctttatcc ccagaccagg catcacctat      300

gagccaccca actataaggc cctggacttc tccgaggccc caagcttcac ccagcccctg      360

gtgaaccgct cggtcatcgc gggctacact gctatgctct gctgtgctgt ccggggtagc      420

cccaagccca agatttcctg gttcaagaat ggcctggacc tgggagaaga cgcccgcttc      480

cgcatgttca gcaagcaggg agtgttgact ctggagatta gaaagccctg cccctttgac      540

gggggcatct atgtctgcag ggccaccaac ttacagggcg aggcacggtg tgagtgccgc      600

ctggaggtgc gagtgcctca g                                                621


<210>  32
<211>  282
<212>  DNA
<213>  Homo sapiens

<400>  32
ccaagcttca cccagcccct ggtgaaccgc tcggtcatcg cgggctacac tgctatgctc       60

tgctgtgctg tccggggtag ccccaagccc aagatttcct ggttcaagaa tggcctggac      120

ctgggagaag acgcccgctt ccgcatgttc agcaagcagg gagtgttgac tctggagatt      180

agaaagccct gcccctttga cgggggcatc tatgtctgca gggccaccaa cttacagggc      240

gaggcacggt gtgagtgccg cctggaggtg cgagtgcctc ag                         282


<210>  33
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacg                   168


<210>  34
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  35
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  36
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  37
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  38
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  39
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  40
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  41
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  42
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  43
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  44
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  45
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Pro Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Leu Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Val 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr Gln Thr Leu Ala Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Ser Ser Met Ala Asn Gln Ala Arg Asn Trp Val Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Asn Gln Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Ala Lys Phe Lys Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Met Asn Pro Gly Val Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Ala Gly Asn Asp Gly Val Asp Tyr Ser Gln Val Leu Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Glu 
                565                 570                 575     


Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala Ala Asn Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Leu Val His Asn Gln Gly Val Ile Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Leu Thr Phe Asn Gln Ala Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  46
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  47
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  48
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly Phe 
    450                 455                 460                 


Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile Phe 
    530                 535                 540                 


Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met 
545                 550                 555                 560 


Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro 
            580                 585                 590         


Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  49
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Asn Ala Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Thr Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  50
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr 
        435                 440                 445             


Asn Ala Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Thr Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Leu Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  51
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Ala Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Thr Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Arg Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Thr Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Arg Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  52
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Gln Gln Asn Thr Ala Pro Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  53
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  53

Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr 
1               5                   10                  15      


Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly 
            20                  25                  30          


Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp 
        35                  40                  45              


Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys 
    50                  55                  60                  


Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn 
65                  70                  75                  80  


Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val 
                85                  90                  95      


Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg 
            100                 105                 110         


Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro 
        115                 120                 125             


Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln 
    130                 135                 140                 


Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr 
145                 150                 155                 160 


Ile Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln 
                165                 170                 175     


Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu 
            180                 185                 190         


Gln Val Val Asp Lys Pro Ser Pro 
        195                 200 


<210>  54
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  54

Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr 
1               5                   10                  15      


Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly 
            20                  25                  30          


Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp 
        35                  40                  45              


Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys 
    50                  55                  60                  


Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn 
65                  70                  75                  80  


Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val 
                85                  90                  95      


Gln Glu Ile Leu Gln Arg Pro Arg 
            100                 


<210>  55
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  55

Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr 
1               5                   10                  15      


Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln 
            20                  25                  30          


Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu 
        35                  40                  45              


Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu 
    50                  55                  60                  


Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val Thr 
65                  70                  75                  80  


Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln Val 
                85                  90                  95      


Val Asp Lys Pro Ser Pro 
            100         


<210>  56
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  56

Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr 
1               5                   10                  15      


Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly 
            20                  25                  30          


Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser Glu Trp 
        35                  40                  45              


Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu Val Lys 
    50                  55                  60                  


Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn 
65                  70                  75                  80  


Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val Thr Val 
                85                  90                  95      


Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg 
            100                 105                 110         


Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro 
        115                 120                 125             


Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln 
    130                 135                 140                 


Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr 
145                 150                 155                 160 


Ile Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln 
                165                 170                 175     


Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu 
            180                 185                 190         


Gln Val Val Asp Lys Pro Ser Pro Pro Gln Asp Leu Arg Val Thr Asp 
        195                 200                 205             


Ala Trp Gly Leu Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Val 
    210                 215                 220                 


Gly Asn Thr Glu Leu Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys 
225                 230                 235                 240 


Thr Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys 
                245                 250                 255     


Val Val Pro Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe 
            260                 265                 270         


Ser Gln Asn Met Val Gly Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu 
        275                 280                 285             


Pro Val Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu Pro Pro Asn Tyr 
    290                 295                 300                 


Lys Ala Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr Gln Pro Leu Val 
305                 310                 315                 320 


Asn Arg Ser Val Ile Ala Gly Tyr Thr Ala Met Leu Cys Cys Ala Val 
                325                 330                 335     


Arg Gly Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp 
            340                 345                 350         


Leu Gly Glu Asp Ala Arg Phe Arg Met Phe Ser Lys Gln Gly Val Leu 
        355                 360                 365             


Thr Leu Glu Ile Arg Lys Pro Cys Pro Phe Asp Gly Gly Ile Tyr Val 
    370                 375                 380                 


Cys Arg Ala Thr Asn Leu Gln Gly Glu Ala Arg Cys Glu Cys Arg Leu 
385                 390                 395                 400 


Glu Val Arg Val Pro Gln 
                405     


<210>  57
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp 
1               5                   10                  15      


Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro 
            20                  25                  30          


Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp 
        35                  40                  45              


Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg 
    50                  55                  60                  


Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn 
65                  70                  75                  80  


Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro 
                85                  90                  95      


Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr 
            100                 105                 110         


Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln 
        115                 120                 125             


Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu 
    130                 135                 140                 


Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu 
145                 150                 155                 160 


Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly Thr Tyr Gln Val Thr 
                165                 170                 175     


Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Val Leu Gln Val 
            180                 185                 190         


Val Asp Lys Pro Ser Pro Pro Gln Asp Leu Arg Val Thr Asp Ala Trp 
        195                 200                 205             


Gly Leu Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Val Gly Asn 
    210                 215                 220                 


Thr Glu Leu Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met 
225                 230                 235                 240 


Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val 
                245                 250                 255     


Pro Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser Gln 
            260                 265                 270         


Asn Met Val Gly Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro Val 
        275                 280                 285             


Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu Pro Pro Asn Tyr Lys Ala 
    290                 295                 300                 


Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr Gln Pro Leu Val Asn Arg 
305                 310                 315                 320 


Ser Val Ile Ala Gly Tyr Thr Ala Met Leu Cys Cys Ala Val Arg Gly 
                325                 330                 335     


Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly 
            340                 345                 350         


Glu Asp Ala Arg Phe Arg Met Phe Ser Lys Gln Gly Val Leu Thr Leu 
        355                 360                 365             


Glu Ile Arg Lys Pro Cys Pro Phe Asp Gly Gly Ile Tyr Val Cys Arg 
    370                 375                 380                 


Ala Thr Asn Leu Gln Gly Glu Ala Arg Cys Glu Cys Arg Leu Glu Val 
385                 390                 395                 400 


Arg Val Pro Gln 
                


<210>  58
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp 
1               5                   10                  15      


Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro 
            20                  25                  30          


Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp 
        35                  40                  45              


Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala Arg 
    50                  55                  60                  


Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val Asn 
65                  70                  75                  80  


Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro 
                85                  90                  95      


Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val Ser 
            100                 105                 110         


Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala 
        115                 120                 125             


Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys Ser 
    130                 135                 140                 


Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile Leu 
145                 150                 155                 160 


Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala 
                165                 170                 175     


His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro Val 
            180                 185                 190         


Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Gln Val Val Asp Lys Pro 
        195                 200                 205             


Ser Pro Pro Gln Asp Leu Arg Val Thr Asp Ala Trp Gly Leu Asn Val 
    210                 215                 220                 


Ala Leu Glu Trp Lys Pro Pro Gln Asp Val Gly Asn Thr Glu Leu Trp 
225                 230                 235                 240 


Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr 
                245                 250                 255     


Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val Pro Glu Leu Ile 
            260                 265                 270         


Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser Gln Asn Met Val Gly 
        275                 280                 285             


Phe Ser Asp Arg Ala Ala Thr Thr Lys Glu Pro Val Phe Ile Pro Arg 
    290                 295                 300                 


Pro Gly Ile Thr Tyr Glu Pro Pro Asn Tyr Lys Ala Leu Asp Phe Ser 
305                 310                 315                 320 


Glu Ala Pro Ser Phe Thr Gln Pro Leu Val Asn Arg Ser Val Ile Ala 
                325                 330                 335     


Gly Tyr Thr Ala Met Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro 
            340                 345                 350         


Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg 
        355                 360                 365             


Phe Arg Met Phe Ser Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys 
    370                 375                 380                 


Pro Cys Pro Phe Asp Gly Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu 
385                 390                 395                 400 


Gln Gly Glu Ala Arg Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
                405                 410                 415     


<210>  59
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  59

Pro Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr 
1               5                   10                  15      


Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly 
            20                  25                  30          


Leu Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp 
        35                  40                  45              


Thr Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys 
    50                  55                  60                  


Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn 
65                  70                  75                  80  


Val Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val 
                85                  90                  95      


Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg 
            100                 105                 110         


Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro 
        115                 120                 125             


Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln 
    130                 135                 140                 


Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr 
145                 150                 155                 160 


Ile Leu Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln 
                165                 170                 175     


Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu 
            180                 185                 190         


Gln Ile Val Asp Lys Pro Ser Pro 
        195                 200 


<210>  60
<211>  104
<212>  PRT
<213>  Mus musculus

<400>  60

Pro Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr 
1               5                   10                  15      


Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly 
            20                  25                  30          


Leu Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp 
        35                  40                  45              


Thr Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys 
    50                  55                  60                  


Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn 
65                  70                  75                  80  


Val Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val 
                85                  90                  95      


Gln Glu Ile Leu Gln Arg Pro Arg 
            100                 


<210>  61
<211>  102
<212>  PRT
<213>  Mus musculus

<400>  61

Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr 
1               5                   10                  15      


Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln 
            20                  25                  30          


Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu 
        35                  40                  45              


Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu 
    50                  55                  60                  


Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln Val Thr 
65                  70                  75                  80  


Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu Gln Ile 
                85                  90                  95      


Val Asp Lys Pro Ser Pro 
            100         


<210>  62
<211>  406
<212>  PRT
<213>  Mus musculus

<400>  62

Pro Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser Asp Thr 
1               5                   10                  15      


Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala Gly Gly 
            20                  25                  30          


Leu Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser Glu Trp 
        35                  40                  45              


Thr Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu Val Lys 
    50                  55                  60                  


Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala His Asn 
65                  70                  75                  80  


Val Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val Thr Val 
                85                  90                  95      


Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg 
            100                 105                 110         


Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro 
        115                 120                 125             


Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln 
    130                 135                 140                 


Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr 
145                 150                 155                 160 


Ile Leu Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln 
                165                 170                 175     


Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu 
            180                 185                 190         


Gln Ile Val Asp Lys Pro Ser Pro Pro Gln Asp Ile Arg Ile Val Glu 
        195                 200                 205             


Thr Trp Gly Phe Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Asp 
    210                 215                 220                 


Gly Asn Thr Glu Ile Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys 
225                 230                 235                 240 


Thr Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys 
                245                 250                 255     


Val Val Ser Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe 
            260                 265                 270         


Ser His Asn Met Val Gly Ser Ser Asp Lys Ala Ala Ala Thr Lys Glu 
        275                 280                 285             


Pro Val Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu Pro Pro Lys Tyr 
    290                 295                 300                 


Lys Ala Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr Gln Pro Leu Ala 
305                 310                 315                 320 


Asn Arg Ser Ile Ile Ala Gly Tyr Asn Ala Ile Leu Cys Cys Ala Val 
                325                 330                 335     


Arg Gly Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp 
            340                 345                 350         


Leu Gly Glu Asp Ala Arg Phe Arg Met Phe Cys Lys Gln Gly Val Leu 
        355                 360                 365             


Thr Leu Glu Ile Arg Lys Pro Cys Pro Tyr Asp Gly Gly Val Tyr Val 
    370                 375                 380                 


Cys Arg Ala Thr Asn Leu Gln Gly Glu Ala Gln Cys Glu Cys Arg Leu 
385                 390                 395                 400 


Glu Val Arg Val Pro Gln 
                405     


<210>  63
<211>  404
<212>  PRT
<213>  Mus musculus

<400>  63

Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp 
1               5                   10                  15      


Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro 
            20                  25                  30          


Val Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp 
        35                  40                  45              


Met Arg Leu Asn Phe Asp Leu Leu Arg Glu Leu Ser His Glu Ala Arg 
    50                  55                  60                  


Arg Met Ile Glu Gly Val Ala Tyr Glu Met Arg Val Tyr Ala Val Asn 
65                  70                  75                  80  


Ala Val Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro 
                85                  90                  95      


Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg His Leu Arg Gln Thr 
            100                 105                 110         


Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu Leu Ile Pro Phe Gln 
        115                 120                 125             


Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys Glu Gly Gln Pro Leu 
    130                 135                 140                 


Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro Thr Asp Thr Ile Leu 
145                 150                 155                 160 


Phe Ile Arg Ala Ala Arg Arg Thr His Ser Gly Thr Tyr Gln Val Thr 
                165                 170                 175     


Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr Leu Ile Leu Gln Ile 
            180                 185                 190         


Val Asp Lys Pro Ser Pro Pro Gln Asp Ile Arg Ile Val Glu Thr Trp 
        195                 200                 205             


Gly Phe Asn Val Ala Leu Glu Trp Lys Pro Pro Gln Asp Asp Gly Asn 
    210                 215                 220                 


Thr Glu Ile Trp Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met 
225                 230                 235                 240 


Glu Trp Phe Thr Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val 
                245                 250                 255     


Ser Glu Leu Ile Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser His 
            260                 265                 270         


Asn Met Val Gly Ser Ser Asp Lys Ala Ala Ala Thr Lys Glu Pro Val 
        275                 280                 285             


Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu Pro Pro Lys Tyr Lys Ala 
    290                 295                 300                 


Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr Gln Pro Leu Ala Asn Arg 
305                 310                 315                 320 


Ser Ile Ile Ala Gly Tyr Asn Ala Ile Leu Cys Cys Ala Val Arg Gly 
                325                 330                 335     


Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly 
            340                 345                 350         


Glu Asp Ala Arg Phe Arg Met Phe Cys Lys Gln Gly Val Leu Thr Leu 
        355                 360                 365             


Glu Ile Arg Lys Pro Cys Pro Tyr Asp Gly Gly Val Tyr Val Cys Arg 
    370                 375                 380                 


Ala Thr Asn Leu Gln Gly Glu Ala Gln Cys Glu Cys Arg Leu Glu Val 
385                 390                 395                 400 


Arg Val Pro Gln 
                


<210>  64
<211>  416
<212>  PRT
<213>  Mus musculus

<400>  64

Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu Asp 
1               5                   10                  15      


Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln Pro 
            20                  25                  30          


Val Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg Trp 
        35                  40                  45              


Met Arg Leu Asn Phe Asp Leu Leu Arg Glu Leu Ser His Glu Ala Arg 
    50                  55                  60                  


Arg Met Ile Glu Gly Val Ala Tyr Glu Met Arg Val Tyr Ala Val Asn 
65                  70                  75                  80  


Ala Val Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met Pro 
                85                  90                  95      


Ile Gly Pro Pro Gly Glu Pro Thr His Leu Ala Val Glu Asp Val Ser 
            100                 105                 110         


Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly Ala 
        115                 120                 125             


Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Gln Glu Gly Cys Ser 
    130                 135                 140                 


Glu Trp Thr Pro Ala Leu Gln Gly Leu Thr Glu Arg Thr Ser Met Leu 
145                 150                 155                 160 


Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg Ala 
                165                 170                 175     


His Asn Val Ala Gly Pro Gly Gly Pro Ile Val Thr Lys Glu Pro Val 
            180                 185                 190         


Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Gln Ile Val Asp Lys Pro 
        195                 200                 205             


Ser Pro Pro Gln Asp Ile Arg Ile Val Glu Thr Trp Gly Phe Asn Val 
    210                 215                 220                 


Ala Leu Glu Trp Lys Pro Pro Gln Asp Asp Gly Asn Thr Glu Ile Trp 
225                 230                 235                 240 


Gly Tyr Thr Val Gln Lys Ala Asp Lys Lys Thr Met Glu Trp Phe Thr 
                245                 250                 255     


Val Leu Glu His Tyr Arg Arg Thr His Cys Val Val Ser Glu Leu Ile 
            260                 265                 270         


Ile Gly Asn Gly Tyr Tyr Phe Arg Val Phe Ser His Asn Met Val Gly 
        275                 280                 285             


Ser Ser Asp Lys Ala Ala Ala Thr Lys Glu Pro Val Phe Ile Pro Arg 
    290                 295                 300                 


Pro Gly Ile Thr Tyr Glu Pro Pro Lys Tyr Lys Ala Leu Asp Phe Ser 
305                 310                 315                 320 


Glu Ala Pro Ser Phe Thr Gln Pro Leu Ala Asn Arg Ser Ile Ile Ala 
                325                 330                 335     


Gly Tyr Asn Ala Ile Leu Cys Cys Ala Val Arg Gly Ser Pro Lys Pro 
            340                 345                 350         


Lys Ile Ser Trp Phe Lys Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg 
        355                 360                 365             


Phe Arg Met Phe Cys Lys Gln Gly Val Leu Thr Leu Glu Ile Arg Lys 
    370                 375                 380                 


Pro Cys Pro Tyr Asp Gly Gly Val Tyr Val Cys Arg Ala Thr Asn Leu 
385                 390                 395                 400 


Gln Gly Glu Ala Gln Cys Glu Cys Arg Leu Glu Val Arg Val Pro Gln 
                405                 410                 415     


<210>  65
<211>  600
<212>  RNA
<213>  Homo sapiens

<400>  65
ccccccagcg aacccaccca ccuggcagua gaggacgucu cugacaccac ggucucccuc       60

aaguggcggc ccccagagcg cgugggagca ggaggccugg auggcuacag cguggaguac      120

ugcccagagg gcugcucaga guggguggcu gcccugcagg ggcugacaga gcacacaucg      180

auacugguga aggaccugcc cacgggggcc cggcugcuuu uccgagugcg ggcacacaau      240

auggcagggc cuggagcccc uguuaccacc acggagccgg ugacagugca ggagauccug      300

caacggccac ggcuucagcu gcccaggcac cugcgccaga ccauucagaa gaaggucggg      360

gagccuguga accuucucau cccuuuccag ggcaagcccc ggccucaggu gaccuggacc      420

aaagaggggc agccccuggc aggcgaggag gugagcaucc gcaacagccc cacagacacc      480

auccuguuca uccgggccgc ucgccgcgug cauucaggca cuuaccaggu gacggugcgc      540

auugagaaca uggaggacaa ggccacgcug gugcugcagg uuguugacaa gccaaguccu      600


<210>  66
<211>  312
<212>  RNA
<213>  Homo sapiens

<400>  66
ccccccagcg aacccaccca ccuggcagua gaggacgucu cugacaccac ggucucccuc       60

aaguggcggc ccccagagcg cgugggagca ggaggccugg auggcuacag cguggaguac      120

ugcccagagg gcugcucaga guggguggcu gcccugcagg ggcugacaga gcacacaucg      180

auacugguga aggaccugcc cacgggggcc cggcugcuuu uccgagugcg ggcacacaau      240

auggcagggc cuggagcccc uguuaccacc acggagccgg ugacagugca ggagauccug      300

caacggccac gg                                                          312


<210>  67
<211>  306
<212>  RNA
<213>  Homo sapiens

<400>  67
auccugcaac ggccacggcu ucagcugccc aggcaccugc gccagaccau ucagaagaag       60

gucggggagc cugugaaccu ucucaucccu uuccagggca agccccggcc ucaggugacc      120

uggaccaaag aggggcagcc ccuggcaggc gaggagguga gcauccgcaa cagccccaca      180

gacaccaucc uguucauccg ggccgcucgc cgcgugcauu caggcacuua ccaggugacg      240

gugcgcauug agaacaugga ggacaaggcc acgcuggugc ugcagguugu ugacaagcca      300

aguccu                                                                 306


<210>  68
<211>  1218
<212>  RNA
<213>  Homo sapiens

<400>  68
ccccccagcg aacccaccca ccuggcagua gaggacgucu cugacaccac ggucucccuc       60

aaguggcggc ccccagagcg cgugggagca ggaggccugg auggcuacag cguggaguac      120

ugcccagagg gcugcucaga guggguggcu gcccugcagg ggcugacaga gcacacaucg      180

auacugguga aggaccugcc cacgggggcc cggcugcuuu uccgagugcg ggcacacaau      240

auggcagggc cuggagcccc uguuaccacc acggagccgg ugacagugca ggagauccug      300

caacggccac ggcuucagcu gcccaggcac cugcgccaga ccauucagaa gaaggucggg      360

gagccuguga accuucucau cccuuuccag ggcaagcccc ggccucaggu gaccuggacc      420

aaagaggggc agccccuggc aggcgaggag gugagcaucc gcaacagccc cacagacacc      480

auccuguuca uccgggccgc ucgccgcgug cauucaggca cuuaccaggu gacggugcgc      540

auugagaaca uggaggacaa ggccacgcug gugcugcagg uuguugacaa gccaaguccu      600

ccccaggauc uccgggugac ugacgccugg ggucuuaaug uggcucugga guggaagcca      660

ccccaggaug ucggcaacac ggagcucugg ggguacacag ugcagaaagc cgacaagaag      720

accauggagu gguucaccgu cuuggagcau uaccgccgca cccacugcgu ggugccagag      780

cucaucauug gcaauggcua cuacuuccgc gucuucagcc agaauauggu uggcuuuagu      840

gacagagcgg ccaccaccaa ggagcccguc uuuaucccca gaccaggcau caccuaugag      900

ccacccaacu auaaggcccu ggacuucucc gaggccccaa gcuucaccca gccccuggug      960

aaccgcucgg ucaucgcggg cuacacugcu augcucugcu gugcuguccg ggguagcccc     1020

aagcccaaga uuuccugguu caagaauggc cuggaccugg gagaagacgc ccgcuuccgc     1080

auguucagca agcagggagu guugacucug gagauuagaa agcccugccc cuuugacggg     1140

ggcaucuaug ucugcagggc caccaacuua cagggcgagg cacgguguga gugccgccug     1200

gaggugcgag ugccucag                                                   1218


<210>  69
<211>  1215
<212>  RNA
<213>  Homo sapiens

<400>  69
gugccagacg caccugcggc ccccaagauc agcaacgugg gagaggacuc cugcacagua       60

cagugggagc cgccugccua cgauggcggg cagcccaucc ugggcuacau ccuggagcgc      120

aagaagaaga agagcuaccg guggaugcgg cugaacuucg accugauuca ggagcugagu      180

caugaagcgc ggcgcaugau cgagggcgug guguacgaga ugcgcgucua cgcggucaac      240

gccaucggca uguccaggcc cagcccugcc ucccagcccu ucaugccuau ccugcaacgg      300

ccacggcuuc agcugcccag gcaccugcgc cagaccauuc agaagaaggu cggggagccu      360

gugaaccuuc ucaucccuuu ccagggcaag ccccggccuc aggugaccug gaccaaagag      420

gggcagcccc uggcaggcga ggaggugagc auccgcaaca gccccacaga caccauccug      480

uucauccggg ccgcucgccg cgugcauuca ggcacuuacc aggugacggu gcgcauugag      540

aacauggagg acaaggccac gcuggugcug cagguuguug acaagccaag uccuccccag      600

gaucuccggg ugacugacgc cuggggucuu aauguggcuc uggaguggaa gccaccccag      660

gaugucggca acacggagcu cuggggguac acagugcaga aagccgacaa gaagaccaug      720

gagugguuca ccgucuugga gcauuaccgc cgcacccacu gcguggugcc agagcucauc      780

auuggcaaug gcuacuacuu ccgcgucuuc agccagaaua ugguuggcuu uagugacaga      840

gcggccacca ccaaggagcc cgucuuuauc cccagaccag gcaucaccua ugagccaccc      900

aacuauaagg cccuggacuu cuccgaggcc ccaagcuuca cccagccccu ggugaaccgc      960

ucggucaucg cgggcuacac ugcuaugcuc ugcugugcug uccgggguag ccccaagccc     1020

aagauuuccu gguucaagaa uggccuggac cugggagaag acgcccgcuu ccgcauguuc     1080

agcaagcagg gaguguugac ucuggagauu agaaagcccu gccccuuuga cgggggcauc     1140

uaugucugca gggccaccaa cuuacagggc gaggcacggu gugagugccg ccuggaggug     1200

cgagugccuc aguga                                                      1215


<210>  70
<211>  1248
<212>  RNA
<213>  Homo sapiens

<400>  70
gugccagacg caccugcggc ccccaagauc agcaacgugg gagaggacuc cugcacagua       60

cagugggagc cgccugccua cgauggcggg cagcccaucc ugggcuacau ccuggagcgc      120

aagaagaaga agagcuaccg guggaugcgg cugaacuucg accugauuca ggagcugagu      180

caugaagcgc ggcgcaugau cgagggcgug guguacgaga ugcgcgucua cgcggucaac      240

gccaucggca uguccaggcc cagcccugcc ucccagcccu ucaugccuau cggucccccc      300

agcgaaccca cccaccuggc aguagaggac gucucugaca ccacggucuc ccucaagugg      360

cggcccccag agcgcguggg agcaggaggc cuggauggcu acagcgugga guacugccca      420

gagggcugcu cagagugggu ggcugcccug caggggcuga cagagcacac aucgauacug      480

gugaaggacc ugcccacggg ggcccggcug cuuuuccgag ugcgggcaca caauauggca      540

gggccuggag ccccuguuac caccacggag ccggugacag ugcaggagau ccugcaacgg      600

ccacggcagg uuguugacaa gccaaguccu ccccaggauc uccgggugac ugacgccugg      660

ggucuuaaug uggcucugga guggaagcca ccccaggaug ucggcaacac ggagcucugg      720

ggguacacag ugcagaaagc cgacaagaag accauggagu gguucaccgu cuuggagcau      780

uaccgccgca cccacugcgu ggugccagag cucaucauug gcaauggcua cuacuuccgc      840

gucuucagcc agaauauggu uggcuuuagu gacagagcgg ccaccaccaa ggagcccguc      900

uuuaucccca gaccaggcau caccuaugag ccacccaacu auaaggcccu ggacuucucc      960

gaggccccaa gcuucaccca gccccuggug aaccgcucgg ucaucgcggg cuacacugcu     1020

augcucugcu gugcuguccg ggguagcccc aagcccaaga uuuccugguu caagaauggc     1080

cuggaccugg gagaagacgc ccgcuuccgc auguucagca agcagggagu guugacucug     1140

gagauuagaa agcccugccc cuuugacggg ggcaucuaug ucugcagggc caccaacuua     1200

cagggcgagg cacgguguga gugccgccug gaggugcgag ugccucag                  1248


<210>  71
<211>  600
<212>  RNA
<213>  Mus musculus

<400>  71
cccccuggcg aaccaaccca cuuggcugug gaggaugugu cagacaccac ugucucacuc       60

aaguggcggc ccccagagcg cgugggggcc gguggccugg acggauacag cguggaguac      120

ugccaggagg gaugcuccga guggacaccu gcucugcagg ggcugacaga gcgcacaucg      180

augcugguga aggaccuacc cacuggggca cggcugcugu uccgaguacg ggcacacaau      240

guggcagguc cuggaggccc uaucgucacc aaggagccug ugacagugca ggagauacug      300

caacgaccac ggcuccaacu gcccagacac cugcgccaga ccauccagaa gaaaguuggg      360

gagccuguga accuccucau cccuuuccag ggcaaacccc ggccucaggu gaccuggacc      420

aaagaggggc agccccuggc aggugaggag gugagcaucc ggaacagccc cacagacacg      480

aucuuguuca uccgagcugc ccgccgcacc cacucgggca ccuaccaggu gacaguucgc      540

auugagaaca uggaggacaa ggcaacgcug auccugcaga uuguggacaa gccaaguccu      600


<210>  72
<211>  312
<212>  RNA
<213>  Mus musculus

<400>  72
cccccuggcg aaccaaccca cuuggcugug gaggaugugu cagacaccac ugucucacuc       60

aaguggcggc ccccagagcg cgugggggcc gguggccugg acggauacag cguggaguac      120

ugccaggagg gaugcuccga guggacaccu gcucugcagg ggcugacaga gcgcacaucg      180

augcugguga aggaccuacc cacuggggca cggcugcugu uccgaguacg ggcacacaau      240

guggcagguc cuggaggccc uaucgucacc aaggagccug ugacagugca ggagauacug      300

caacgaccac gg                                                          312


<210>  73
<211>  306
<212>  RNA
<213>  Mus musculus

<400>  73
auacugcaac gaccacggcu ccaacugccc agacaccugc gccagaccau ccagaagaaa       60

guuggggagc cugugaaccu ccucaucccu uuccagggca aaccccggcc ucaggugacc      120

uggaccaaag aggggcagcc ccuggcaggu gaggagguga gcauccggaa cagccccaca      180

gacacgaucu uguucauccg agcugcccgc cgcacccacu cgggcaccua ccaggugaca      240

guucgcauug agaacaugga ggacaaggca acgcugaucc ugcagauugu ggacaagcca      300

aguccu                                                                 306


<210>  74
<211>  1218
<212>  RNA
<213>  Mus musculus

<400>  74
cccccuggcg aaccaaccca cuuggcugug gaggaugugu cagacaccac ugucucacuc       60

aaguggcggc ccccagagcg cgugggggcc gguggccugg acggauacag cguggaguac      120

ugccaggagg gaugcuccga guggacaccu gcucugcagg ggcugacaga gcgcacaucg      180

augcugguga aggaccuacc cacuggggca cggcugcugu uccgaguacg ggcacacaau      240

guggcagguc cuggaggccc uaucgucacc aaggagccug ugacagugca ggagauacug      300

caacgaccac ggcuccaacu gcccagacac cugcgccaga ccauccagaa gaaaguuggg      360

gagccuguga accuccucau cccuuuccag ggcaaacccc ggccucaggu gaccuggacc      420

aaagaggggc agccccuggc aggugaggag gugagcaucc ggaacagccc cacagacacg      480

aucuuguuca uccgagcugc ccgccgcacc cacucgggca ccuaccaggu gacaguucgc      540

auugagaaca uggaggacaa ggcaacgcug auccugcaga uuguggacaa gccaaguccu      600

ccccaggaua uccggaucgu ugagacuugg gguuucaaug uggcucugga guggaagcca      660

ccccaagaug auggcaauac agagaucugg gguuauacug uacagaaagc ugacaagaag      720

accauggagu gguucacggu uuuggaacac uaccgacgca cucacugugu gguaucagag      780

cuuaucauug gcaauggcua cuacuuccgg gucuucagcc auaacauggu ggguuccagu      840

gacaaagcug ccgccaccaa ggagccaguc uuuauuccaa gaccaggcau cacauaugag      900

ccacccaaau acaaggcccu ggacuucucu gaggccccaa gcuucaccca gcccuuggca      960

aaucgcucca ucauugcagg cuauaaugcc auccucugcu gugcuguccg agguaguccu     1020

aagcccaaga uuuccugguu caagaauggc cuggaucugg gagaagaugc ucgcuuccgc     1080

auguucugca agcagggagu auugacccug gagaucagga aacccugccc cuaugauggu     1140

ggugucuaug ucugcagggc caccaacuug cagggcgagg cacaguguga gugccgccug     1200

gaggugcgag uuccucag                                                   1218


<210>  75
<211>  1212
<212>  RNA
<213>  Mus musculus

<400>  75
gucccagaug cuccugcggc cccuaagauc agcaacgugg gcgaggacuc cugcacugug       60

cagugggaac cgccugccua ugauggcggg cagccggucc ugggauacau ccuggagcgc      120

aagaagaaaa agagcuacag guggaugagg cucaacuuug aucugcugcg ggagcugagc      180

cacgaggcga ggcgcaugau cgagggugua gccuaugaga ugcgagucua cgcagucaau      240

gccgugggaa uguccaggcc cagcccugcc ucucagcccu ucaugccuau acugcaacga      300

ccacggcucc aacugcccag acaccugcgc cagaccaucc agaagaaagu uggggagccu      360

gugaaccucc ucaucccuuu ccagggcaaa ccccggccuc aggugaccug gaccaaagag      420

gggcagcccc uggcagguga ggaggugagc auccggaaca gccccacaga cacgaucuug      480

uucauccgag cugcccgccg cacccacucg ggcaccuacc aggugacagu ucgcauugag      540

aacauggagg acaaggcaac gcugauccug cagauugugg acaagccaag uccuccccag      600

gauauccgga ucguugagac uugggguuuc aauguggcuc uggaguggaa gccaccccaa      660

gaugauggca auacagagau cugggguuau acuguacaga aagcugacaa gaagaccaug      720

gagugguuca cgguuuugga acacuaccga cgcacucacu gugugguauc agagcuuauc      780

auuggcaaug gcuacuacuu ccgggucuuc agccauaaca ugguggguuc cagugacaaa      840

gcugccgcca ccaaggagcc agucuuuauu ccaagaccag gcaucacaua ugagccaccc      900

aaauacaagg cccuggacuu cucugaggcc ccaagcuuca cccagcccuu ggcaaaucgc      960

uccaucauug caggcuauaa ugccauccuc ugcugugcug uccgagguag uccuaagccc     1020

aagauuuccu gguucaagaa uggccuggau cugggagaag augcucgcuu ccgcauguuc     1080

ugcaagcagg gaguauugac ccuggagauc aggaaacccu gccccuauga uggugguguc     1140

uaugucugca gggccaccaa cuugcagggc gaggcacagu gugagugccg ccuggaggug     1200

cgaguuccuc ag                                                         1212


<210>  76
<211>  1248
<212>  RNA
<213>  Mus musculus

<400>  76
gucccagaug cuccugcggc cccuaagauc agcaacgugg gcgaggacuc cugcacugug       60

cagugggaac cgccugccua ugauggcggg cagccggucc ugggauacau ccuggagcgc      120

aagaagaaaa agagcuacag guggaugagg cucaacuuug aucugcugcg ggagcugagc      180

cacgaggcga ggcgcaugau cgagggugua gccuaugaga ugcgagucua cgcagucaau      240

gccgugggaa uguccaggcc cagcccugcc ucucagcccu ucaugccuau ugggcccccu      300

ggcgaaccaa cccacuuggc uguggaggau gugucagaca ccacugucuc acucaagugg      360

cggcccccag agcgcguggg ggccgguggc cuggacggau acagcgugga guacugccag      420

gagggaugcu ccgaguggac accugcucug caggggcuga cagagcgcac aucgaugcug      480

gugaaggacc uacccacugg ggcacggcug cuguuccgag uacgggcaca caauguggca      540

gguccuggag gcccuaucgu caccaaggag ccugugacag ugcaggagau acugcaacga      600

ccacggcaga uuguggacaa gccaaguccu ccccaggaua uccggaucgu ugagacuugg      660

gguuucaaug uggcucugga guggaagcca ccccaagaug auggcaauac agagaucugg      720

gguuauacug uacagaaagc ugacaagaag accauggagu gguucacggu uuuggaacac      780

uaccgacgca cucacugugu gguaucagag cuuaucauug gcaauggcua cuacuuccgg      840

gucuucagcc auaacauggu ggguuccagu gacaaagcug ccgccaccaa ggagccaguc      900

uuuauuccaa gaccaggcau cacauaugag ccacccaaau acaaggcccu ggacuucucu      960

gaggccccaa gcuucaccca gcccuuggca aaucgcucca ucauugcagg cuauaaugcc     1020

auccucugcu gugcuguccg agguaguccu aagcccaaga uuuccugguu caagaauggc     1080

cuggaucugg gagaagaugc ucgcuuccgc auguucugca agcagggagu auugacccug     1140

gagaucagga aacccugccc cuaugauggu ggugucuaug ucugcagggc caccaacuug     1200

cagggcgagg cacaguguga gugccgccug gaggugcgag uuccucag                  1248


<210>  77
<211>  5767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttacgggccc cccctcgagg tcgggataaa      240

agcagtctgg gctttcacat gacagcatct ggggctgcgg cagagggtcg ggtccgaagc      300

gctgccttat cagcgtcccc agccctggga ggtgacagct ggctggcttg tgtcagcccc      360

tcgggcactc acgtatctcc gtccgacggg tttaaaatag caaaactctg aggccacaca      420

atagcttggg cttatatggg ctcctgtggg ggaaggggga gcacggaggg ggccggggcc      480

gctgctgcca aaatagcagc tcacaagtgt tgcattcctc tctgggcgcc gggcacattc      540

ctgctggctc tgcccgcccc ggggtgggcg ccggggggac cttaaagcct ctgcccccca      600

aggagccctt cccagacagc cgccggcacc caccgctccg tgggacgatc cccgaagctc      660

tagagcttta ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac      720

acaacagtct cgaacttaag ctgcagaagt tggtcgtgag gcactgggca ggtaagtatc      780

aaggttacaa gacaggttta aggagaccaa tagaaactgg gcttgtcgag acagagaaga      840

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc      900

acaggtgtcc actcccagtt caattacagc tcttaaggct agagtactta atacgactca      960

ctataggcta gcctcgagaa gcggccgcac tactccgcgg actactacta gtatggccgt     1020

ttacccatac gatgttcctg actatgcggg ctatccctat gacgtcccgg actatgcagg     1080

atcctatcca tatgacgttc cagattacgc taccggtccc cccagcgaac ccacccacct     1140

ggcagtagag gacgtctctg acaccacggt ctccctcaag tggcggcccc cagagcgcgt     1200

gggagcagga ggcctggatg gctacagcgt ggagtactgc ccagagggct gctcagagtg     1260

ggtggctgcc ctgcaggggc tgacagagca cacatcgata ctggtgaagg acctgcccac     1320

gggggcccgg ctgcttttcc gagtgcgggc acacaatatg gcagggcctg gagcccctgt     1380

taccaccacg gagccggtga cagtgcagga gatcctgcaa cggccacggc ttcagctgcc     1440

caggcacctg cgccagacca ttcagaagaa ggtcggggag cctgtgaacc ttctcatccc     1500

tttccagggc aagccccggc ctcaggtgac ctggaccaaa gaggggcagc ccctggcagg     1560

cgaggaggtg agcatccgca acagccccac agacaccatc ctgttcatcc gggccgctcg     1620

ccgcgtgcat tcaggcactt accaggtgac ggtgcgcatt gagaacatgg aggacaaggc     1680

cacgctggtg ctgcaggttg ttgacaagcc aagtcctaag cttggacaat tgggagagct     1740

cggatccgga gccacgaact tctctctgtt aaagcaagca ggagacgtgg aagaaaaccc     1800

cggtcctgcc atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt     1860

cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga     1920

tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc     1980

ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga     2040

ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg     2100

caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg     2160

cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat     2220

cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa     2280

gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt     2340

gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc     2400

cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga     2460

tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct     2520

gtacaagtaa taagctcgcg tggtacctct agagtcgacc cgggcggcct cgaggacggg     2580

gtgaactacg cctgaggatc cgatcttttt ccctctgcca aaaattatgg ggacatcatg     2640

aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat tgcaatagtg     2700

tgttggaatt ttttgtgtct ctcactcgga agcaattcgt tgatctgaat ttcgaccacc     2760

cataataccc attaccctgg tagataagta gcatggcggg ttaatcatta actacaagga     2820

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     2880

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     2940

gcgcagcctt aattaaccta attcactggc cgtcgtttta caacgtcgtg actgggaaaa     3000

ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa     3060

tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg     3120

ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac     3180

cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc     3240

cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt     3300

tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg     3360

gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag     3420

tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt     3480

ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt     3540

taacgcgaat tttaacaaaa tattaacgct tacaatttag gtggcacttt tcggggaaat     3600

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     3660

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa     3720

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac     3780

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac     3840

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt     3900

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc     3960

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca     4020

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc     4080

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     4140

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     4200

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     4260

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     4320

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     4380

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     4440

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     4500

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     4560

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     4620

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     4680

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     4740

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     4800

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     4860

agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc     4920

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     4980

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     5040

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     5100

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg     5160

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     5220

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     5280

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     5340

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     5400

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     5460

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata     5520

cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt     5580

cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag     5640

gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga     5700

taacaatttc acacaggaaa cagctatgac catgattacg ccagatttaa ttaaggcctt     5760

aattagg                                                               5767


<210>  78
<211>  5749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttacgggccc cccctcgagg tcgggataaa      240

agcagtctgg gctttcacat gacagcatct ggggctgcgg cagagggtcg ggtccgaagc      300

gctgccttat cagcgtcccc agccctggga ggtgacagct ggctggcttg tgtcagcccc      360

tcgggcactc acgtatctcc gtccgacggg tttaaaatag caaaactctg aggccacaca      420

atagcttggg cttatatggg ctcctgtggg ggaaggggga gcacggaggg ggccggggcc      480

gctgctgcca aaatagcagc tcacaagtgt tgcattcctc tctgggcgcc gggcacattc      540

ctgctggctc tgcccgcccc ggggtgggcg ccggggggac cttaaagcct ctgcccccca      600

aggagccctt cccagacagc cgccggcacc caccgctccg tgggacgatc cccgaagctc      660

tagagcttta ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac      720

acaacagtct cgaacttaag ctgcagaagt tggtcgtgag gcactgggca ggtaagtatc      780

aaggttacaa gacaggttta aggagaccaa tagaaactgg gcttgtcgag acagagaaga      840

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc      900

acaggtgtcc actcccagtt caattacagc tcttaaggct agagtactta atacgactca      960

ctataggcta gcctcgagaa gcggccgcac tactccgcgg actactacta gtatggccgt     1020

ttacccatac gatgttcctg actatgcggg ctatccctat gacgtcccgg actatgcagg     1080

atcctatcca tatgacgttc cagattacgc taccggtttc atgcctattg ggccccctgg     1140

cgaaccaacc cacttggctg tggaggatgt gtcagacacc actgtctcac tcaagtggcg     1200

gcccccagag cgcgtggggg ccggtggcct ggacggatac agcgtggagt actgccagga     1260

gggatgctcc gagtggacac ctgctctgca ggggctgaca gagcgcacat cgatgctggt     1320

gaaggaccta cccactgggg cacggctgct gttccgagta cgggcacaca atgtggcagg     1380

tcctggaggc cctatcgtca ccaaggagcc tgtgacagtg caggagatac tgcaacgacc     1440

acggctccaa ctgcccagac acctgcgcca gaccatccag aagaaagttg gggagcctgt     1500

gaacctcctc atccctttcc agggcaaacc ccggcctcag gtgacctgga ccaaagaggg     1560

gcagcccctg gcaggtgagg aggtgagcat ccggaacagc cccacagaca cgatcttgtt     1620

catccgagct gcccgccgca cccactcggg cacctaccag gtgacagttc gcattgagaa     1680

catggaggac aaggcaacga agcttggaca attgggagag ctcggatccg gagccacgaa     1740

cttctctctg ttaaagcaag caggagacgt ggaagaaaac cccggtcctg ccatggtgag     1800

caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt     1860

aaacggccac aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct     1920

gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac     1980

caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga     2040

cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga     2100

cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg     2160

catcgagctg aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga     2220

gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa     2280

ggtgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta     2340

ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag     2400

cacccagtcc gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga     2460

gttcgtgacc gccgccggga tcactctcgg catggacgag ctgtacaagt aataagctcg     2520

cgtggtacct ctagagtcga cccgggcggc ctcgaggacg gggtgaacta cgcctgagga     2580

tccgatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg     2640

acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt     2700

ctctcactcg gaagcaattc gttgatctga atttcgacca cccataatac ccattaccct     2760

ggtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     2820

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     2880

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagcc ttaattaacc     2940

taattcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact     3000

taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac     3060

cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg     3120

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     3180

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     3240

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     3300

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac     3360

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     3420

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat     3480

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     3540

aatattaacg cttacaattt aggtggcact tttcggggaa atgtgcgcgg aacccctatt     3600

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     3660

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     3720

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     3780

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     3840

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     3900

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     3960

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     4020

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     4080

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     4140

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     4200

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     4260

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     4320

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     4380

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     4440

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     4500

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     4560

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     4620

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     4680

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     4740

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     4800

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     4860

aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     4920

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     4980

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     5040

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     5100

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     5160

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     5220

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     5280

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     5340

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     5400

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     5460

cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc     5520

gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc     5580

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac     5640

tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga     5700

aacagctatg accatgatta cgccagattt aattaaggcc ttaattagg                 5749


