                         б

<110>  ݿƼ޹˾
 
<120>  һ־εϸƱ

<130>  0141-PA-023

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA3

<400>  1
cuagggacug cacagucaa                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA4

<400>  2
gaguugaugu cagucacuu                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA5

<400>  3
cugcgugccc ugccaagaa                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA6

<400>  4
aggauccaga ucuaacuug                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA7

<400>  5
auccagaucu aacuugggg                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA8

<400>  6
guccaauguu ccaaccuac                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA11

<400>  7
ugacugacau caacuccaa                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA12

<400>  8
gugacugaca ucaacucca                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA13

<400>  9
guaacauacc uggaggaca                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA14

<400>  10
auugcucaac aaccaugcu                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA15

<400>  11
acugcgugcc cugccaaga                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA16

<400>  12
gagagggcuc accagaggu                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA17

<400>  13
uguaacauac cuggaggac                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA18

<400>  14
agccacccca aguuagauc                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Fas gRNA20

<400>  15
uguguacucc uucccuucu                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA1

<400>  16
uguggaaguc acgcccguu                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA2

<400>  17
cgugacuucc acaugagcg                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA3

<400>  18
acgaagcucu ccgaugugu                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA4

<400>  19
ccuucgguca ccacgagca                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA5

<400>  20
agcuuguccg ucugguugc                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA6

<400>  21
cugcucgugg ugaccgaag                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA7

<400>  22
gggcccggcg caaugacag                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA8

<400>  23
cucucuuuga ucugcgccu                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA9

<400>  24
ucucuuugau cugcgccuu                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA10

<400>  25
ugucacacaa cugcccaac                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA11

<400>  26
gaucugcgcc uugggggcc                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA12

<400>  27
gacguuaccu cgugcggcc                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA13

<400>  28
gggaugacgu uaccucgug                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA14

<400>  29
acguuaccuc gugcggccc                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  PD-1 gRNA15

<400>  30
accaggguuu ggaacuggc                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  TCR gRNA1

<400>  31
gagucucuca gcugguaca                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  TCR gRNA2

<400>  32
gucaugagca gauuaaacc                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  TCR gRNA3

<400>  33
auuaaacccg gccacuuuc                                                    19


<210>  34
<211>  90
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ1

<400>  34
guuuuagagc uaugcuggaa acagcauagc aaguuaaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu                                        90


<210>  35
<211>  80
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ2

<400>  35
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu                                                   80


<210>  36
<211>  82
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ3

<400>  36
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uu                                                82


<210>  37
<211>  50
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ4

<400>  37
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuuuuuuu                  50


<210>  38
<211>  56
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ5

<400>  38
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucauu uuuuuu           56


<210>  39
<211>  69
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ6

<400>  39
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

guuuuuuuu                                                               69


<210>  40
<211>  92
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ7

<400>  40
guuuuagagc uaugcuggaa acagcauagc aaguuaaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


<210>  41
<211>  92
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ8

<400>  41
guuucagagc uaugcuggaa acagcauagc aaguugaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugcuuuu uu                                     92


<210>  42
<211>  84
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ9

<400>  42
guuuuagagc uaugaaaaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa       60

guggcaccga gucggugcuu uuuu                                              84


<210>  43
<211>  88
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ10

<400>  43
guuuuagagc uaugcgaaag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gcuuuuuu                                          88


<210>  44
<211>  98
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ11

<400>  44
guuuuagagc uaugcuguuu gaaaaaacag cauagcaagu uaaaauaagg cuaguccguu       60

aucaacuuga aaaaguggca ccgagucggu gcuuuuuu                               98


<210>  45
<211>  102
<212>  RNA
<213>  ˹УArtificial Sequence

<220>
<223>  Ǽ12

<400>  45
guuuuagagc uaugcuguuu uggaaacaaa acagcauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu uu                         102


<210>  46
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Gly Phe Pro Glu Gln Arg Leu Leu Leu Leu His Val Ser Phe 
1               5                   10                  15      


Pro Glu Arg Gly Ile Asn Ile Thr Trp Glu Leu Met Leu Arg Val Cys 
            20                  25                  30          


Ala Gln Gly Trp His Ala Gln Gly Leu Pro His Gly Thr Asn Ser Leu 
        35                  40                  45              


Leu Lys Gly Gly Thr Glu Thr Ser Leu Ser Thr Pro Thr Arg Leu Val 
    50                  55                  60                  


Val Leu Thr Ser Val Ala Arg Leu Ser Ser Lys Ser Val Asn Ala Gln 
65                  70                  75                  80  


Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val Thr 
                85                  90                  95      


Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln Phe 
            100                 105                 110         


Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr 
        115                 120                 125             


Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys Glu 
    130                 135                 140                 


Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu 
145                 150                 155                 160 


Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg Thr 
                165                 170                 175     


Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr 
            180                 185                 190         


Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile Ile 
        195                 200                 205             


Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser 
    210                 215                 220                 


Arg Ser Asn Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu 
225                 230                 235                 240 


Ile Val Trp Val Lys Arg Lys Glu Val Gln Lys Thr Cys Arg Lys His 
                245                 250                 255     


Arg Lys Glu Asn Gln Gly Ser His Glu Ser Pro Thr Leu Asn Pro Glu 
            260                 265                 270         


Thr Val Ala Ile Asn Leu Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr 
        275                 280                 285             


Thr Ile Ala Gly Val Met Thr Leu Ser Gln Val Lys Gly Phe Val Arg 
    290                 295                 300                 


Lys Asn Gly Val Asn Glu Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn 
305                 310                 315                 320 


Val Gln Asp Thr Ala Glu Gln Lys Val Gln Leu Leu Arg Asn Trp His 
                325                 330                 335     


Gln Leu His Gly Lys Lys Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu 
            340                 345                 350         


Lys Lys Ala Asn Leu Cys Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile 
        355                 360                 365             


Leu Lys Asp Ile Thr Ser Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu 
    370                 375                 380                 


Ile Gln Ser Leu Val 
385                 


<210>  47
<211>  2283
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CD24-P2A-PDL1F-IRES-FasLF

<400>  47
atgggcagag caatggtggc caggctcggg ctggggctgc tgctgctggc actgctccta       60

cccacgcaga tttattccag tgaaacaaca actggaactt caagtaactc ctcccagagt      120

acttccaact ctgggttggc cccaaatcca actaatgcca ccaccaaggc ggctggtggt      180

gccctgcagt caacagccag tctcttcgtg gtctcactct ctcttctgca tctctactct      240

catatgcgcc gcaagcgcgg ctccggtgcc acgaacttct ctctgttaaa gcaagcagga      300

gacgtggaag aaaaccccgg tcctttcgaa atgaggatat ttgctgtctt tatattcatg      360

acctactggc atttgctgaa cgcatttact gtcacggttc ccaaggacct atatgtggta      420

gagtatggta gcaatatgac aattgaatgc aaattcccag tagaaaaaca attagacctg      480

gctgcactaa ttgtctattg ggaaatggag gataagaaca ttattcaatt tgtgcatgga      540

gaggaagacc tgaaggttca gcatagtagc tacagacaga gggcccggct gttgaaggac      600

cagctctccc tgggaaatgc tgcacttcag atcacagatg tgaaattgca ggatgcaggg      660

gtgtaccgct gcatgatcag ctatggtggt gccgactaca agcgaattac tgtgaaagtc      720

aatgccccat acaacaaaat caaccaaaga attttggttg tggacccagt cacctctgaa      780

catgaactga catgtcaggc tgagggctac cccaaggccg aagtcatctg gacaagcagt      840

gaccatcaag tcctgagtgg taagaccacc accaccaatt ccaagagaga ggagaagctt      900

ttcaatgtga ccagcacact gagaatcaac acaacaacta atgagatttt ctactgcact      960

tttaggagat tagatcctga ggaaaaccat acagctgaat tggtcatccc agaactacct     1020

ctggcacatc ctccaaatga aaggactcac ttggtaattc tgggagccat cttattatgc     1080

cttggtgtag cactgacatt catcttctaa cccccccccc taacgttact ggccgaagcc     1140

gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata ttgccgtctt     1200

ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc     1260

tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc     1320

tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc     1380

cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca cctgcaaagg     1440

cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct     1500

cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat     1560

ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc     1620

taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgataa taccatgctg     1680

tgtctccttg tgatgttttt catggttctg gttgccttgg taggattggg cctggggatg     1740

tttcagctct tccacctaca gaaggagctg gcagaactcc gagagtctac cagccagatg     1800

cacacagcat cagaggaagc cgcagctata ggccacccca gtccaccccc tgaaaaaaag     1860

gagctgagga aagtggccca tttaacaggc aagtccaact caaggtccat gcctctggaa     1920

tgggaagaca cctatggaat tgtcctgctt tctggagtga agtataagaa gggtggcctt     1980

gtgatcaatg aaactgggct gtactttgta tattccaaag tatacttccg gggtcaatct     2040

tgcaacaacc tgcccctgag ccacaaggtc tacatgagga actctaagta tccccaggat     2100

ctggtgatga tggaggggaa gatgatgagc tactgcacta ctgggcagat gtgggcccgc     2160

agcagctacc tgggggcagt gttcaatctt accagtgctg atcatttata tgtcaacgta     2220

tctgagctct ctctggtcaa ttttgaggaa tctcagacgt ttttcggctt atataagctc     2280

taa                                                                   2283


<210>  48
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  49
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  49

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  50
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Glu Glu Ala 
        115                 120                 125             


Ala Ala Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  51
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val 
1               5                   10                  15      


Gly Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu 
            20                  25                  30          


Ala Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Glu Glu 
        35                  40                  45              


Ala Ala Ala Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu 
    50                  55                  60                  


Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro 
65                  70                  75                  80  


Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys 
                85                  90                  95      


Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val 
            100                 105                 110         


Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu 
        115                 120                 125             


Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val 
    130                 135                 140                 


Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp 
145                 150                 155                 160 


Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp 
                165                 170                 175     


His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu 
            180                 185                 190         


Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        195                 200         


<210>  52
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  52

Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met 
1               5                   10                  15      


Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val 
            20                  25                  30          


Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe 
        35                  40                  45              


Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro 
    50                  55                  60                  


Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu 
65                  70                  75                  80  


Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met 
                85                  90                  95      


Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala 
            100                 105                 110         


Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu 
        115                 120                 125             


Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
    130                 135                 


<210>  53
<211>  846
<212>  DNA
<213>  Homo sapiens

<400>  53
atgcagcagc ccttcaatta cccatatccc cagatctact gggtggacag cagtgccagc       60

tctccctggg cccctccagg cacagttctt ccctgtccaa cctctgtgcc cagaaggcct      120

ggtcaaagga ggccaccacc accaccgcca ccgccaccac taccacctcc gccgccgccg      180

ccaccactgc ctccactacc gctgccaccc ctgaagaaga gagggaacca cagcacaggc      240

ctgtgtctcc ttgtgatgtt tttcatggtt ctggttgcct tggtaggatt gggcctgggg      300

atgtttcagc tcttccacct acagaaggag ctggcagaac tccgagagtc taccagccag      360

atgcacacag catcagagga agccgcagct ataggccacc ccagtccacc ccctgaaaaa      420

aaggagctga ggaaagtggc ccatttaaca ggcaagtcca actcaaggtc catgcctctg      480

gaatgggaag acacctatgg aattgtcctg ctttctggag tgaagtataa gaagggtggc      540

cttgtgatca atgaaactgg gctgtacttt gtatattcca aagtatactt ccggggtcaa      600

tcttgcaaca acctgcccct gagccacaag gtctacatga ggaactctaa gtatccccag      660

gatctggtga tgatggaggg gaagatgatg agctactgca ctactgggca gatgtgggcc      720

cgcagcagct acctgggggc agtgttcaat cttaccagtg ctgatcattt atatgtcaac      780

gtatctgagc tctctctggt caattttgag gaatctcaga cgtttttcgg cttatataag      840

ctctaa                                                                 846


<210>  54
<211>  609
<212>  DNA
<213>  Homo sapiens

<400>  54
atgctgtgtc tccttgtgat gtttttcatg gttctggttg ccttggtagg attgggcctg       60

gggatgtttc agctcttcca cctacagaag gagctggcag aactccgaga gtctaccagc      120

cagatgcaca cagcatcaga ggaagccgca gctataggcc accccagtcc accccctgaa      180

aaaaaggagc tgaggaaagt ggcccattta acaggcaagt ccaactcaag gtccatgcct      240

ctggaatggg aagacaccta tggaattgtc ctgctttctg gagtgaagta taagaagggt      300

ggccttgtga tcaatgaaac tgggctgtac tttgtatatt ccaaagtata cttccggggt      360

caatcttgca acaacctgcc cctgagccac aaggtctaca tgaggaactc taagtatccc      420

caggatctgg tgatgatgga ggggaagatg atgagctact gcactactgg gcagatgtgg      480

gcccgcagca gctacctggg ggcagtgttc aatcttacca gtgctgatca tttatatgtc      540

aacgtatctg agctctctct ggtcaatttt gaggaatctc agacgttttt cggcttatat      600

aagctctaa                                                              609


<210>  55
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  55
ctgaggaaag tggcccattt aacaggcaag tccaactcaa ggtccatgcc tctggaatgg       60

gaagacacct atggaattgt cctgctttct ggagtgaagt ataagaaggg tggccttgtg      120

atcaatgaaa ctgggctgta ctttgtatat tccaaagtat acttccgggg tcaatcttgc      180

aacaacctgc ccctgagcca caaggtctac atgaggaact ctaagtatcc ccaggatctg      240

gtgatgatgg aggggaagat gatgagctac tgcactactg ggcagatgtg ggcccgcagc      300

agctacctgg gggcagtgtt caatcttacc agtgctgatc atttatatgt caacgtatct      360

gagctctctc tggtcaattt tgaggaatct cagacgtttt tcggcttata taagctc         417


<210>  56
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  57
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe 
            


<210>  58
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  58
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggacccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttctaa      780


<210>  59
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


<210>  60
<211>  243
<212>  DNA
<213>  Homo sapiens

<400>  60
atgggcagag caatggtggc caggctcggg ctggggctgc tgctgctggc actgctccta       60

cccacgcaga tttattccag tgaaacaaca actggaactt caagtaactc ctcccagagt      120

acttccaact ctgggttggc cccaaatcca actaatgcca ccaccaaggc ggctggtggt      180

gccctgcagt caacagccag tctcttcgtg gtctcactct ctcttctgca tctctactct      240

taa                                                                    243


<210>  61
<211>  870
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  P2A-PDL1F

<400>  61
catatgcgcc gcaagcgcgg ctccggtgcc acgaacttct ctctgttaaa gcaagcagga       60

gacgtggaag aaaaccccgg tcctttcgaa atgaggatat ttgctgtctt tatattcatg      120

acctactggc atttgctgaa cgcatttact gtcacggttc ccaaggacct atatgtggta      180

gagtatggta gcaatatgac aattgaatgc aaattcccag tagaaaaaca attagacctg      240

gctgcactaa ttgtctattg ggaaatggag gataagaaca ttattcaatt tgtgcatgga      300

gaggaagacc tgaaggttca gcatagtagc tacagacaga gggcccggct gttgaaggac      360

cagctctccc tgggaaatgc tgcacttcag atcacagatg tgaaattgca ggatgcaggg      420

gtgtaccgct gcatgatcag ctatggtggt gccgactaca agcgaattac tgtgaaagtc      480

aatgccccat acaacaaaat caaccaaaga attttggttg tggacccagt cacctctgaa      540

catgaactga catgtcaggc tgagggctac cccaaggccg aagtcatctg gacaagcagt      600

gaccatcaag tcctgagtgg taagaccacc accaccaatt ccaagagaga ggagaagctt      660

ttcaatgtga ccagcacact gagaatcaac acaacaacta atgagatttt ctactgcact      720

tttaggagat tagatcctga ggaaaaccat acagctgaat tggtcatccc agaactacct      780

ctggcacatc ctccaaatga aaggactcac ttggtaattc tgggagccat cttattatgc      840

cttggtgtag cactgacatt catcttctaa                                       870


<210>  62
<211>  333
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  P2A-CD24

<400>  62
catatgcgcc gcaagcgcgg ctccggtgcc acgaacttct ctctgttaaa gcaagcagga       60

gacgtggaag aaaaccccgg tcctttcgaa atgggcagag caatggtggc caggctcggg      120

ctggggctgc tgctgctggc actgctccta cccacgcaga tttattccag tgaaacaaca      180

actggaactt caagtaactc ctcccagagt acttccaact ctgggttggc cccaaatcca      240

actaatgcca ccaccaaggc ggctggtggt gccctgcagt caacagccag tctcttcgtg      300

gtctcactct ctcttctgca tctctactct taa                                   333


<210>  63
<211>  178
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  FasL-M1

<400>  63

Met Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu 
1               5                   10                  15      


Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Thr Leu Gln Val 
            20                  25                  30          


Ser His Arg Tyr Pro Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly 
        35                  40                  45              


Lys Ser Asn Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly 
    50                  55                  60                  


Ile Val Leu Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile 
65                  70                  75                  80  


Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly 
                85                  90                  95      


Gln Ser Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn 
            100                 105                 110         


Ser Lys Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser 
        115                 120                 125             


Tyr Cys Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala 
    130                 135                 140                 


Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu 
145                 150                 155                 160 


Leu Ser Leu Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr 
                165                 170                 175     


Lys Leu 
        


<210>  64
<211>  243
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  FasL-M2

<400>  64

Met Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val 
1               5                   10                  15      


Ala Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp 
            20                  25                  30          


Lys Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser 
        35                  40                  45              


Tyr Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln 
    50                  55                  60                  


Val Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr 
65                  70                  75                  80  


Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser 
                85                  90                  95      


Pro Leu Val Arg Glu Arg Lys Glu Leu Arg Lys Val Ala His Leu Thr 
            100                 105                 110         


Gly Lys Ser Asn Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr 
        115                 120                 125             


Gly Ile Val Leu Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val 
    130                 135                 140                 


Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg 
145                 150                 155                 160 


Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg 
                165                 170                 175     


Asn Ser Lys Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met 
            180                 185                 190         


Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly 
        195                 200                 205             


Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser 
    210                 215                 220                 


Glu Leu Ser Leu Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu 
225                 230                 235                 240 


Tyr Lys Leu 
            