                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC 
       IL17A AND/OR IL17F

<130>  1

<150>  CN202010681755.8
<151>  2020-07-15

<150>  CN202011586262.2
<151>  2020-12-28

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser 
            20                  25                  30          


Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys 
        35                  40                  45              


Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg 
    50                  55                  60                  


Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His 
65                  70                  75                  80  


Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
                85                  90                  95      


Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
            100                 105                 110         


Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
        115                 120                 125             


Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
    130                 135                 140                 


Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala 
145                 150                 155             


<210>  2
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  3
<211>  3708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  3
tagtactcat tactgggact tcccatcata gaattgttca gagtggtcct cagaagcaca       60

aattataggt aagactgagt taaaatgtag atctggataa gatcctagct ttaccaattc      120

cataaggcct cccatgtggt cattattgca aataccctcc taccttaaca acaaatcttt      180

cctttaagtg tcaatttggg atttttttcc agtccaggtt gggcatcttc atacagtagc      240

tcctacattt aggacctaag gacactttct ctagaactgt tctctattaa acaaaaccaa      300

tggagaagga gccttatgca atactgtaca atgcattaaa ctaaatggca cctacctgtt      360

caaacagcca ttgtcttctt taaattagga tgcatgttaa ccactttaaa ctgtgaaatc      420

cctccttttt acagaccact gctgttattg ctttttcctg aaaagggcca tagaatacaa      480

attagtgaaa taatagattc tcaatggtag ccctgccatc tgagcagaaa acaaaactga      540

tttttatgtt tttagtaacg tcttaatttt ccaccacact gagacaaaag atattttatc      600

ctgtttacaa aagtaagaat tttcccttat ttttggtgtt atcctctctt ataggtagaa      660

aataatactg tataatggcc taatgatttc aagaagcccc aaagtatctt ttcccttaaa      720

acatcacttg actacaagca tcctcctgtt tcataccctc ccacacacag ccctggtcct      780

taaactgtag ctgcccagtc ttgtagctgc tgttttgaat ctgcagagaa gcaagatgga      840

tacacttgaa ggccactcct gagcaaaatc atcattccta acctactgct tttgtttatt      900

cattgctatt ttccttctgc aaaaagtcaa ccacaatgaa caggtgagac aaaacctcat      960

tttataaaac agaagagcat gtctacaaaa aagatgaagt aggtctcaga aaggcaaagg     1020

cacaacgaaa gtgaagatgc caatctcttg gtaccctcag cacaccaggt ctcactatgg     1080

ccttccttct gcctctgaag gctaagagcc aatcctgaat aacagcaagc acaaaagaaa     1140

cctgaccttc tgtgcacagc ccctgtgttc ccaattgctc ctccaaggac aaggctttca     1200

gatggaggga gtctctatgg ctgggaaatc cgttcttctc aaagccaggc acagccagct     1260

ccatgtctaa atcttcacac tgttgtgaaa actgatcttg tctctccccc ttccctttat     1320

ttttagacaa agattgtcac ctctcaaagg cccatacata ggctgagttt tacgactgtg     1380

ggacagtgga ctggggagat tattagatct tcctcttcat catcagttga cagatttggc     1440

aggaaacctc ttcctctcct gccagatagc aacaaggagt gtttattcct tggagttcag     1500

cataggctac aacatagtca tacacttttc aaaggcataa ggatttagag ccaagggata     1560

agacaaccca ggaatgtctt agactgcagc tgagttctaa aaagaaacaa ggtcatgaat     1620

ttctgacata atgtttcata ttgccaatca ataacaacaa caacaacaaa agttcagctg     1680

ttattttcta aaccctatgc agttggtaca aagattaaca aaatagctac aggtgttcaa     1740

gtaacttaca atatagaaag taaatcagta agcaaacaat atacaggtca agagaaacag     1800

acagccacat accaaagaga caaatgagtc taaagtaatc catggagctg gagagatggc     1860

tcagcagtta agagtactga ctgctcttcc agaggtcttg agttcaattc ccagaaacca     1920

catggtggct cacaaccatt tgtaatggga tctgatacct tcttctggtg tgtctgaaga     1980

tagcatcagt gtattcacat atattaaata aataaatatt ttttaaaaag taatccatga     2040

agacctatgt tgtataaaaa gttatattat gtacaacaaa atttaagaaa atgagtaaca     2100

cattagccca taaagaagcc aatgttgtgg tatgtttatt ccagtgatgt tattccccga     2160

tagaataact atttgaatag gatcctacaa gtgtgctgat aaacagggtg aaagaggaca     2220

ttgcctaggc tgtattttaa cagaaggtat gtaatttgta gaaggatgac acgtagaaag     2280

ccaggacctg gtgaacccta acatggagca tagtaacatg gaggctagaa gggatgttaa     2340

ttcaaactgc aatactaatt caaggagttc atgcttctca ttcaggaagc tagagaatgg     2400

gaaaagacct ggcaatcaga ggtgtgtgtg agcattatcc cagggataat gccaagggta     2460

ttatcccaag ggtatcccaa gaagtgtcag aaaagcaaac atgatccaaa caggtgaaag     2520

tcagagttac cagccagcaa aagacctaga aagaagagca aggtgtgagg tgctgcaact     2580

tctgagaaca cggtgatcat gaacagaatc cagcaatcct accagacatg ccatctattg     2640

aacaggagct atcggtccac ctcatgctgc atgtcagaca aaagctgaag agctgggacc     2700

taatgacccc catattcacc atcttgtcct catatctgct attcctgaag aaaaagactt     2760

ctcaaagaca taaaggcaaa ggtcatctca tggagaggag agaacatgag agagctgttt     2820

ccatcttccc ttctcatccc tcatctcctc ctgttagtag tctccacccg gcagtgcctc     2880

agtgtctcca ctgtctttca gccttcatct tgatttctaa ttctttcttc gatttatcca     2940

atcagtccct tattctttca cttcatttcc ttcctcctta aaagaaaggc ttgataccga     3000

acctcaaaac agcaaatatt aacaggtttc ttgataacat gcaaccgtaa tgacttcact     3060

agtaaacctc atgtctctcg ctactcctta ataactaact agcctttgtg attgtttctt     3120

gcagagaata gacattcaag gaaaaacagt tgcggtactc agttaaatag aacgtgttcc     3180

gttggtgtta aattatttat tttgtatgtc tgtttacata ctaagacatt gagtgggttt     3240

ctttgggcaa gggatgctct ctagccaggg aatttggtag aaaagtgaga aagatcaagt     3300

caaaattcaa agtgtgtgtc actaggagac tgtcaagaga ctcacaaacc attactatgg     3360

agcccagctc tgcagcagct tcagatatgt ccatacacac atgatactga atcacagcaa     3420

agcatctctg ttcagctccc aagaagtcat gcttctttgc atagtgaact tctgcccttc     3480

ccatctacct tcgagacaga tgttgcccgt cataaagggg tggttctgtg ctgacctcat     3540

ttgaggatgg aatctttact caaatggtgt caccccccaa cccactcttg acgtaagtga     3600

ccacagaggt agtaaaaccg tataaaaaga gagaaaggag cactactctt catccacctc     3660

acacgaggca caagtgcacc cagcaccagc tgatcaggac gcgcaaac                  3708


<210>  4
<211>  4765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  4
atctgtagct cggggaacat catgagagag gagcagaaag attgtaagag cagaacaaca       60

ggaagtctgc tgggaaacag tctcctagaa atgtcttcat gaacaagcca agacaatatc      120

aatggatata ttaacatgga aggggtaatt tcctcaggtc ctacccctaa acaaagaact      180

acaggcatcc attgacttct gggagaatgt aaaagcctct accagagatg agccccttat      240

tgtttgccta atgcagagca gtcagccctg aaaccatatg cacaacaaca acaaaaatgg      300

actcagcagg ttgtgagtgc atgtgtgtgt gtgtgtatgt gtatgcaaac acatacatgt      360

gcatatacat gtatgtggca ataataaaga aaaatactat catttaagag tggaggtata      420

tggaaggggt tcaaggaaga gtgggtctgg aggaagaaag ggaagtggaa aatgacatga      480

ttctatctgt accaaaaaaa acactttttt aaaatgtaat atgttgagtc ccccaggaag      540

tagggaggtc tggtggggtg ggaggaatgc aatgaagaac tgtcagaagg tagaccagaa      600

gggggataat gaccagactg taaaaaagag attaaagaaa ataaatttta taaataaata      660

aattaattaa ttgattgatt gattccaaca aaaatagtat attttacacg attataaatt      720

tgtggtaatt gtacatgaat aatagaaatt tgtgactgca caaatttgga tttcaatcct      780

ggctttcctt attcgctgct ccctgagaaa tatttctaag cctcttccct cttaatccat      840

gaaatagaaa actgtgagag taaaacataa ataaataaag aatggcgtag tctctgatag      900

gtgtcagtag agaaggacac atacagcctt ctcccctgtc agtcttccct aaaacaatgc      960

ggcagtgcag atgtttgcac agggtcacat tctgtgagat actgtaagta ttacagatga     1020

gtttcagcac aatggaagga tggagggagg ttacatgcaa acaccactat cttatgcaag     1080

gagatgagcg tctgcagact ttgatatgtg ggagggactg tcctgttact cacctcaaac     1140

actctgaagg tcttttgaac ttcagcccct tcagctctcc cctgttggga aaaatatgcc     1200

tcagagtaac aatgcccttg aaccacccaa ctccacattt ccaatttcat attgccttta     1260

agacaatgag gacaaggctc ttcccgtacc aggcaatgct atgagcagaa gcattctgca     1320

ataaattaag caaaaagaac agtggcccta ggaaaagaca catcgctgtt agagaccggg     1380

gtgggggggg ggggggcgtc ctaaaactat aacctgatat ttgacataaa agaaattctt     1440

caaggaaact ctgttttcaa aataggagtc cttgctgtga tgaccaaggg ccaccagaga     1500

tcaggattcc ctctcagagc ttaggtctgc cctcagtctc tcatccagtg cacccaagca     1560

ttcagaaggg aagcggcaag aaagagtcag cctcaagaat aaaagttgtt caacacaagc     1620

aaagtcaaaa ctgagtcata tttgccaaca ggtcagtttc aagctttgaa tcatagccat     1680

cccagtcccc acgcccgagc ctgttattat gcccagttca gggatccttc tgaatggttc     1740

tccagccatt cccacgggct ctctgcttct tcttttaatt aatttctttg ggaagaggaa     1800

gcaggcacct ttagctgctg agctgtctca ttagccttca ctctttactc tctagcaggt     1860

ccatcaccac ccagaggtct acagtacagc ttccctctcc ttcattctaa tcccaaagcc     1920

aggaggcaac ttccccagtt cctcttgtca ctagcacctt gtgctctttc agcttggtac     1980

tgagagccaa cgcgtcacaa gcacacacgc acacacacag ccactgtagt ggtttgaatg     2040

tgcctggccc agtgagtggc actattagga gatgtggcct tgttggagtg ggtgtggcct     2100

tgttagagaa agtgtgtcac tgtgggcatg agctttaaga ccctcatccc agcttcattg     2160

gaagacagtc ttctagcggc cttcagatga agatgtagaa ctcgcagctc ctccagcatt     2220

atgccatgct cccaccttga tgataataga ctgaatctct gaacctgtaa gccagtccca     2280

attaaacgtt gtccttacaa gagttgcctt ggtcatgtgt ctgttcacag cagtaaaatt     2340

ctaagacaca cacacatatg cgcatggggg gggaggggag agagagagag agcattcaca     2400

ggtgctatct taatgtttta taatcctgct gctcatcatt tctttgggct tcgcagcatg     2460

gaagctttag gagcaccact aaggaagagc acacatgaac ctgtagtccc agaccgttat     2520

ttcatattag ttttactatt attggaggct aggaaaaagc cttctgtctt aggatttttg     2580

ttgttgttgt tgttgttgtt tgtttgtttg tttgtttgtt tttttagtgt tgttataact     2640

gtaacaaaaa ttttgaattc tgtttattaa gaaaagagat ttatttcact gacagttcta     2700

gagttgatgg ccattgcacc tgcatcctgc atcagtgtag cttctggtca aggcttcatg     2760

gcaaatgtca tccacataaa gaaacatgtc ctaaagtggc atagagagga ggtaccaggc     2820

tcttctagaa cagcccatct gtcaggacag tcccatgaga cctggtctgc tctctaatga     2880

cagtactgat ctctcccaac agtgattcct tctacaacta aattaccttg cactaggtct     2940

aactctttaa agctgtaagc acttcaaacc caccacaatg gagaccgagt atccagcagt     3000

ggatatttag agaccttatt ggatactttt ttgttttttc tttttctagg aattcaatgg     3060

tgtgttattt tagtgtactt tatttattca ctttacatcc caatcacagc ccccccccaa     3120

cctgtcatcc cccctcctcc ctgcttctct tctcctctag aaggatggag gggtcccctg     3180

ggcatccact ccccaccctg gcacatcaag tctctgaaag gctaggtgct tcctctccca     3240

ctgaggccag acaaaacagc ccagctagaa gaacatatcc cacagacagc caactgcttt     3300

gaggatagct cccgttccag ttgttcagga cccacatgaa gaccaagctg cacatctgct     3360

acatatgaac agggaggcct aggtccagtc catgtatgct tttttgttgg tagttcagtc     3420

cctgagaccc tccaagggtc caggttaatt gactgtgttg gtcttcctgt ggagttccta     3480

tccccttcag gctgaaatcc tttcttctgt tcttctataa gagcccagga gctccatcta     3540

ctgtttgtct gaagctccac aacctctcca aacagtgctg taagctagtc attaaatgct     3600

taaagatgca cctacagggg acagttcaca gaacaatctt gcgcatctct cattccctga     3660

tacacatcac ttggattcta actttgtctt cccaactctc accattgctc tggatggttt     3720

ccatgcgcct gcagatgcta cctacacaca aagtcaaagg ccacaaagta ctgtctggtt     3780

tacctcacgc cactttctgc ataggtatgt tctaagtgca gtgaggttca cagcctgtgc     3840

actggggctc ctctgctgga atggcttaac ctttctttcc tagttgttcc tagttgctcc     3900

tctttttttt cacagattta tttatttatt tatttattta tttatttatt tattgtacgt     3960

gagtacactg tcactctatt cagagacacc agaaattaca ttacagatgt ctgtgagcca     4020

ccatgtggtt gctgggattt gaactcggga cctctggtta agagctactg ctcttaaccg     4080

ctgagctatc tctccagccc tgctagctct tctttatatt catagccttc ctttccttcc     4140

tgctatacct taaccctatt ttgtgatgaa agcatgtggc aaaggaaaca aaatgagaga     4200

gaataagagt ctgaggtcgc agccccttca agggtctgcc cacaaaagcc ttactgcctt     4260

ctattaggtc tcatctgcta aaggttccac ctcctcccac tatcactaaa ggctaggaac     4320

caaaccccta acatgcagcc cttcagaaaa cactggccaa aacaacatca tgcctggatt     4380

tgttcattct tacccactca tttcaagctc aatgctttgc cttatacaac aaaactcttc     4440

ccttcatatt cacaagggct tcacatcctt aggatccatg ttttgtgtct tttgctacct     4500

ttctcaagat gctctgtgga gacagggagt gattagaaga cctcatagat gggcccagac     4560

gaccaagagt ggttgctaat gcccctatct cagagtatcc atgatggagc aggatttaat     4620

gagaggcatt gaagaattgc cttcacaagc tgtgtaacta ggtttttctc cactgaagca     4680

aacccaactg accaaatgca gtttatgtcc tttctcagca cagagccaca gagtatggat     4740

ccaatgtgac agaaaccggt cagtg                                           4765


<210>  5
<211>  2861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 52186432-52189292 of NCBI accession number
       NC_000006.12

<400>  5
atgactcctg ggaagacctc attggtggtg agtcctgcac taacgtgcga tgctcttgct       60

gatttggacc agatagtatt tctggaccgt gggcatgaaa cgctgggttc tgactatgga      120

gatccaggaa tactgtatat gtaggatagg aaatgaaagc tttggtaggt atttaagtca      180

ttgtgcagca ttttcaagaa ctgatacaca gcagtttgaa agataagatt aaaactgaaa      240

gatagctata ttggggctaa accacacaag aagtgtcaca tgatgctgtg cagtaagaaa      300

gaaaatttat tgaaagtctg tttttctgag tacaaaggat ttaatataat tctcccacgg      360

catttttctt taaaatgggt cactatcctt gagattttga aagccgtagc agcaacaacc      420

tttgtttcca ttatctcgta ccatattctc agtacattga aactatgtat tctaactaaa      480

cataggtata actgtgtttt agaataagtg gggtttatat tttttaaata tttaacttca      540

agtatctttt ttgaaatctg attttattac agaatcaata catgttaaat ttagaacaac      600

tggaaaatat acctaagaaa acatgaagga gatcgagttt ttagttggat gcctgccagt      660

agcaccaaca gcacttctag catgaatatt gataccacat agattttcta tagctctttc      720

ttccaatgtg aatgtttgac ttcacgatga gtttcacaga atatgggact gagaacaatg      780

gtgcaggagg atatttctac ctagaaaatc aaggttatta ttccttccca gacctgacaa      840

tgatgcatgt gctgataggc taatgacatg ccatgacttg acatttttat taaaattatt      900

gccaaccaat ggataacatg tctttcctaa gtcaaaagga gaatgttgaa actagttttt      960

ttaaaaaaat tttaaagcca tggtgttaac attatgttgg tcatctacct agatttttct     1020

ctagctgatc tgaaaaatgt agtatagatt gtcctggaac attgtgtgtt ctctatgatt     1080

agcaatgcat catcatcaca attaatttgt caaaaagaac cacatagtaa tctaatctcc     1140

aacctctctc tcctttccca ttcaattcta gtcactgcta ctgctgctga gcctggaggc     1200

catagtgaag gcaggaatca caatcccacg aaatccagga tgcccaaatt ctgaggacaa     1260

gaacttcccc cggactgtga tggtcaacct gaacatccat aaccggaata ccaataccaa     1320

tcccaaaagg tcctcagatt actacaaccg atccacctca ccttggaatc tccagtacgt     1380

aaagcttcca gataaaaatg ctatattctt catccctctt atgcatcaga ctgccagtta     1440

aatctccctg aggatgattt tattcattta gaattaccag tcaaacctgg aaggaccact     1500

gtgaagagca attctcaaac tttctacaga tttctttaac caagcacagg acagcctcca     1560

ataatcccta tcctgttaga tctaattgtc actgacacca ataatcaacc caaattaatt     1620

ataatcatta ttctaatatt tatgagaccc caagtctatt ctttatttat tcaaagaata     1680

gacatttatc aaagaggatt aatgctttta ttatcttaac cagagctgcc attgagaaga     1740

tttattgcaa ataattaata attagggttt tttactttta ttcttttgct tatttttgtt     1800

tttgaatccc agtggaataa gtatcactgg ggtatttcta cccctttgtg tgttaaatag     1860

tcttgatcta cttcctaaca tacctatgct tgctgtatcc ttagtatacc cagtatttag     1920

accccatcaa gggttaaata ccaaatgtat tttgatcatt tgacttcata caaataagtc     1980

tctgttctgt ggagcctaca gattggtctg attgtaggat ttcttctctt cttcccatta     2040

ctaggaagag tcaaaataaa tcaattcaaa aatgcaagca aatcattcac tgatctaaaa     2100

gagagaggga agagaaggtc atagagacac ttaacctttt gtttccagcc ctttatctca     2160

gctctgggct ctgtcccacg aatgtgatct cagataaaat tttgatgtat tccctcttca     2220

aagacagact tcatcaagtc aaataaacag ctatcttatt ctagatggtt ccaagtctac     2280

tcttcctttg gtcttcttct gtctgtcaaa tgtaccctaa aaaagctatc atttgtgtca     2340

aacttaaatt ttttctgtgg cctcagtcta tcttatttta ttcattcttc aaataaattg     2400

gagaaaaact gatcactgtc ttcttttcta taacaattca cgtgcttgaa aaaaaaatcc     2460

aatttgtccc caaagttctt cttcaaacta acatcattta aagaatttgc aatgcctata     2520

atttgtcatc ctgtgaactt gcctctcttc atgtattcct gttttatttc tttcccactt     2580

taccaggaat tcactttcct cctgattttt ctcccctctg cagccgcaat gaggaccctg     2640

agagatatcc ctctgtgatc tgggaggcaa agtgccgcca cttgggctgc atcaacgctg     2700

atgggaacgt ggactaccac atgaactctg tccccatcca gcaagagatc ctggtcctgc     2760

gcagggagcc tccacactgc cccaactcct tccggctgga gaagatactg gtgtccgtgg     2820

gctgcacctg tgtcaccccg attgtccacc atgtggccta a                         2861


<210>  6
<211>  1162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence  sequence of the modified humanized mouse IL17A

<400>  6
atccacctca cacgaggcac aagtgcaccc agcaccagct gatcaggacg cgcaaacatg       60

actcctggga agacctcatt ggtgtcactg ctactgctgc tgagcctgga ggccatagtg      120

aaggcaggaa tcacaatccc acgaaatcca ggatgcccaa attctgagga caagaacttc      180

ccccggactg tgatggtcaa cctgaacatc cataaccgga ataccaatac caatcccaaa      240

aggtcctcag attactacaa ccgatccacc tcaccttgga atctccaccg caatgaggac      300

cctgagagat atccctctgt gatctgggag gcaaagtgcc gccacttggg ctgcatcaac      360

gctgatggga acgtggacta ccacatgaac tctgtcccca tccagcaaga gatcctggtc      420

ctgcgcaggg agcctccaca ctgccccaac tccttccggc tggagaagat actggtgtcc      480

gtgggctgca cctgtgtcac cccgattgtc caccatgtgg cctaaacaga gacccgcggc      540

tgacccctaa gaaaccccca cgtttctcag caaacttact tgcattttta aaacagttcg      600

tgctattgat tttcagcaag gaatgtggat tcagaggcag attcagaatt gtctgccctc      660

cacaatgaaa agaaggtgta aaggggtccc aaactgcttc gtgtttgttt ttctgtggac      720

tttaaattat ttgtgtattt acaatatccc aagatagctt tgaagcgtaa cttattttaa      780

tgaagtatct acattattat tatgtttctt tctgaagaag acaaaattca agactcagaa      840

attttattat ttaaaaggta aagcctatat ttatatgagc tatttatgaa tctatttatt      900

tttcttcagt atttgaagta ttaagaacat gattttcaga tctacctagg gaagtcctaa      960

gtaagattaa atattaatgg aaatttcagc tttactattt gtttatttaa ggttctctcc     1020

tctgaatggg gtgaaaacca aacttagttt tatgtttaat aactttttaa attattgaag     1080

attcaaaaaa ttggataatt tagctcccta ctctgtttta aaaaaaaatt gtaacaatat     1140

cactgtaata ataaagtttt gg                                              1162


<210>  7
<211>  161
<212>  PRT
<213>  Mus musculus

<400>  7

Met Lys Cys Thr Arg Glu Thr Ala Met Val Lys Ser Leu Leu Leu Leu 
1               5                   10                  15      


Met Leu Gly Leu Ala Ile Leu Arg Glu Val Ala Ala Arg Lys Asn Pro 
            20                  25                  30          


Lys Ala Gly Val Pro Ala Leu Gln Lys Ala Gly Asn Cys Pro Pro Leu 
        35                  40                  45              


Glu Asp Asn Thr Val Arg Val Asp Ile Arg Ile Phe Asn Gln Asn Gln 
    50                  55                  60                  


Gly Ile Ser Val Pro Arg Glu Phe Gln Asn Arg Ser Ser Ser Pro Trp 
65                  70                  75                  80  


Asp Tyr Asn Ile Thr Arg Asp Pro His Arg Phe Pro Ser Glu Ile Ala 
                85                  90                  95      


Glu Ala Gln Cys Arg His Ser Gly Cys Ile Asn Ala Gln Gly Gln Glu 
            100                 105                 110         


Asp Ser Thr Met Asn Ser Val Ala Ile Gln Gln Glu Ile Leu Val Leu 
        115                 120                 125             


Arg Arg Glu Pro Gln Gly Cys Ser Asn Ser Phe Arg Leu Glu Lys Met 
    130                 135                 140                 


Leu Leu Lys Val Gly Cys Thr Cys Val Lys Pro Ile Val His Gln Ala 
145                 150                 155                 160 


Ala 
    


<210>  8
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  9
<211>  2892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  9
aattgaggga aatttggatg gagcttggag ctgaccagtc tctgtcaccc attcctgtgt       60

agggaggaaa gtgtaggggc aagtgtgcag atgttctgcc accagcgagc acacaagagt      120

aatgtacaaa gctaagctgg gaagattcac actctatgac tgaacacctt cagtttcaat      180

attctcctag ctgtttccca tcctacagga tttgaatcac acctatcaat cccctttaaa      240

ggtggaattt aaacctgtaa aatctcccga ctcccctgag aagatggatt gtttctattg      300

tttttccata ctcagcacca gccttatcag agctgcaaaa caccaaaaaa caaacaaaca      360

aacaaacaaa accccaaaaa cgcataaagc aaacagtggt ttgtggcttt caatacttct      420

gtcttactga tgcagtgcag agagtgttta gaattcgtgg ctcttgaaat tagacacagt      480

gaagactaat gtgaagaata gtaatgacct tcagtcgctg tggccaagcc ttgccataga      540

aggtggatcc tatagattgt cacgatgagg ctggggaacc ctgccgggtt gtttattgcc      600

tctctgacat aagtcctttg agagctgatt agatagttag gatgagtttc atctatgagt      660

tagctgttca aatcttgtgt gaaaacattt tctaaaatac tccaagaatg tctagctatt      720

aataaagaaa cataatgagc tgttagggac atgatcgttg tcttagttat ttttcgattg      780

ctgtgataaa acactgtaac catggcaaca tataaaagga agtgtttaat ttggggctta      840

cagttgccaa gggttaagct gcttgatcat catggctgga ggcaggaagg taggcatggc      900

gctggggaag ttgctgggag ttcacatctt aagacataac catgaggcag aaagaactaa      960

ctgggaatga tataagactt gaaatttcga agcccacctc agtgacacac ctcctccaac     1020

aagaccacac ctcctactcc ttcccaaata attccaccaa ctggggacca agcatccaca     1080

taaataagcc tatgcaggtt gcttcgcagt tcaaccacca caacaactta cattaatcac     1140

ataaccccga actatagtga ctttcagtct tgctagtcaa aatgagaagt gagacaataa     1200

acatgacata taagaagaaa gagaagattc tggaggagaa atttacttaa gaaatctaaa     1260

gaagtggttg atagatgtgt gactatgttt tctaaatttc aaagcacctg tgaagactgc     1320

attttacatc catcccatgc acagggtaac atcaatacac tgccaaccgt tgttgccttg     1380

tggaactact gcatgcttac agggatcttt gggatttatg aggatgtagg aaaccaagtc     1440

attgtgcggt gagtcctata aatgaattat ggactccaca cagttaactc tagagataat     1500

gcctgaaacc acaacactgt ggcctcgagg attagctact cagtgaacga atgacttcag     1560

aggcgaaggc atatggctgc tgattatctg gagacaaatc tgtttcatcc tgcagcttgc     1620

tttcaatgta ttatcagtga tcgtagtcca gcaggctgac tccatgacct ctttgtttat     1680

tctgcatatt tcttgcctcc aggatgttga aaagaacagg caaatcttta aatccaacat     1740

gcacagtcac tttccctacc tacacagtgt gagcctgaac aacacggagc ccagaaatga     1800

aaagctcagc cttagctctt ctgccttacc atgggctttg ttcttcccca ggaaggtgtg     1860

agcagggacg gcaaaggaca tttgcaccca aggggagctg ttgaggtttt agctcttctt     1920

gtgtttagag ctccactgag cactttgtgt gcgctagtaa cagcagcgaa actgatttca     1980

gtgttagtac agaaaagata gattctagag ctaaaagaaa tgggttctgc actctgagtg     2040

atgccaggcg tcatcagtgt ccctgcttct ttcaattagc atggataaat gaaattttgc     2100

tgtgcttagt ttcccataat ccttttactc aatgagcgtg gcataactat actggttaat     2160

ttaactgggc tgccctgttc attcacttcc ccactctctc attcattcag aaagttttca     2220

tggaccaact atgctctcgc aggaagttaa ctctgagtct ggtatgaaca cagatatgac     2280

atctttagag aacagaaaaa atacttcttg agtgatacat gctaaaatct ttattattta     2340

atgttgataa atatactttt aaaaaaatat ttattgtatg tataagagtt cactgtttct     2400

gcctttagac acaccagaag agggcattgg atgccattac agatggttgt gagccactat     2460

gtggttgctg ggaactgaac tcaggacctc tagaagagca atcagtgctc ttagctgtgg     2520

agccattcct ccatcccaat aaatatactt ctaattgaat tacatatggg accttgacag     2580

tagggtgagg tttggtggaa tgtcccagag aaaggttttg tggactataa ggccggagat     2640

aaactccaga gagctttact cctgaccctt tctgctttgt atcctgataa cattaaacac     2700

ggcagttctc attgctagtg aaccatgaaa aaaaaaaaaa aaaagaaacc ttgatcctgt     2760

aaagtgaccc tatacagagt tcaagtacat tgcccaccac cagggctcta acctgtggta     2820

atctctattt tccaggtcaa gtctttgcta ctgttgatgt tgggacttgc cattctgagg     2880

gaggtagcag ct                                                         2892


<210>  10
<211>  4058
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  10
cttctctcca tgatggaact tgtaaacgta acaattccat tcccctctaa gttgtttttg       60

ttcatggtgt ttaacatggc agcacagaaa gcagctagac aagtatttgc ttctgccttc      120

agcttgaact ccaagacttt acaaccctca acattttgaa catctgtata tcatttgttt      180

ttccaaattt cctcctcaga gctcccatgt tagagttatt gttattaatg gaactgaggt      240

cccgttacac ttagaaagag agttaaggga aatggtgcaa atggaattca agtgtggggc      300

cagcatgtta cacttccagc cttctggcca catcttgtta caaagcaaac acttactgtc      360

cactttgcta gcttctggag ttatgatgtg gagaaagatg tacgtagaag agccactgta      420

ttggcagtag ccacccccag aaccctgtca ttagggccac atggttcctt tgccttcttc      480

tccctatgac ttctaggggt caccataaat cttttatcag actcccatgc tacttgccgg      540

ccaatacaca gtatgcagac cctaggctcc agggaaacgt gtgtctcccc tctgtctccc      600

ttgcctggat acagtgcacc acatctctct ttcactgcta ctatgctttg agagcatcta      660

tattgcagct acattccagg tttctaaaat ctctatgctc cagaggaagt agaaagtgag      720

gtctttctcc tatctgggag ttggtttggg gtcaggcagg gagcaggaac ttggctccct      780

tgtctaactt gtctatgata ggcaggatgt tgggcaggct ccctttagtc atttacaagt      840

gaatcctgct gcagacaaca gtagggttca ttgcctaatg accccaccca tggttagctc      900

tgggtgcagg actgcaggag tggcagaggc ctggcaattc cccaagataa ctcgggtgat      960

gtcaaacaga cctgaattct gaggatcaat taaaggttgg agagaaagag attcctcttg     1020

atggtagtct tccatgatta aggtcaaata gaacactcta gtccctgatt tacttctctc     1080

atttatgaat gtagcctgga ggaattggct ggcttgctca gtgtcactca agaagttact     1140

ggcaggattg gatctgcagg ctccgagttc aagaccttta cattttggtt ttctagcatt     1200

gccaaaaaat ataaaagatg gatggactag tattagctgt gggagaaaat acagaagtac     1260

cttatcctac ctctcccaat actttcattg ctcacaaagc cccccagagg ctaagccaag     1320

cttggcttcc tcactcgtgg ctaatgctgg ctgtcatcag gaaacagcac agcctgttcg     1380

attcacaagg tggcacatgg aacccacaca ttcttggatt ccttagcaga gagagaagag     1440

gaagaaatgg ctgctttatg gggacacctg tttgctcagg ggatgtgtgc aactgtggag     1500

cagagtgagc atgctgcact catcagcttt gccaagctgt ctgagaggca gaagtccccc     1560

attttgcctg aagatacaga cgaagttgca tgctttacat ttttgaatag agggtagcat     1620

cgtagtacgt ggagagattt ccacataaaa acttgaaaac acatggctat ttcctttctt     1680

tcctttcctc tgtccctccc tctctttgct tgttggctga cccctcttta atgcctcata     1740

tagatcaagc tgtcctggag cttgaacctc taatcctcct gcacctacct cctgagtgct     1800

gggattacag gtatgtacca tgacaaccag gtttatgggg attcctgcat gctagttatt     1860

taatttttta atatttagtt atttatgaag gtattgggtg aaagggaaac taatattgat     1920

tctcctctat cccatgccct tgtcttaata atgacaaatg acaaatgcaa gcacacccct     1980

tgtacccaac atcaaagttc tttgtaatct gctctgttgt gggccatcca gtggctctcg     2040

aggaacaggg tatggctgaa gcggcagact caggttgaaa gagagggaac tagatggatg     2100

ggagaaagac cagagctagg acaagattct gatcaaagct caattttagt attcggaaca     2160

cggggttata aagaagggag aggggcccat tcctgccaaa tcatctttgg agtccagctg     2220

caggtgacca catgagtact ctggaacagc taggtggcag atagcagcag tgggagtggc     2280

agaacaatag tgtggcagac tccacccctc gatgatctcc tagtgataac agtcaagcct     2340

gatcagccag atttcaggca ggggagggag ggggaggtta catctcctcc ctgttgttaa     2400

tataaaaaag aaaggctggg ctgaggcata aaatttattt atgctctata gttctgcctg     2460

aattcttagg gtctaatgaa gaaacctttc tcagtgggat tccctaactt ttctcatggt     2520

aaacccttgt ttggttaaga ctgtcctttc tgtcctagta aacattttgc agactagccc     2580

tgagctgttg gatctgtctt ttgtaatgct aattagttac tgaataggta acctccttgc     2640

tgaattccta ctgaattcca agtagtcagc tacatgctct ttctaggaca ttggaacact     2700

ggtgaagact taactgtatt aggataaaat tttaaaaggc actatagtaa gataacgcta     2760

aaggagagta tgtggacctc cttaacagca ggcaggctgt taaggagggt gacaagcagg     2820

gaacaaagag gagggggtga tgaccggctc cttagcacaa ggccatttgg cttgttagga     2880

tgggaggctg tgaagggctt gccttttcac ggtgtggtct ccaacctctc tccccccttt     2940

caattaaatt taataaggcc acacttaact gaggtgatca aatgatcttc tcatctttgg     3000

atgagtgggc attaaccgtg gctgggggag cattgacccg attcctcccg tgggtgctgt     3060

catgacccac aatcatggct cttggtatct tttggggagg ggaggcagag ccttagaaaa     3120

atacttttgg ttgtaactgg aactagatac caacctccat ccaaatcggc tgtgtctttc     3180

agggaactca gaaatggtca agttggacct tcccctgcag tgcttagttt cgtacccatg     3240

ctggtgccca tactggattt gtattatcac gaaccagcat gcacagttct gtgtactgtg     3300

cagctcccaa gggagaattg tcaacctcag attcagcaag acctctacaa gaattatgcc     3360

acttgtaata ccacaatttt tggctcttag gctaatttag gagctggagg tcaccctcct     3420

catccctaat atttccacag cctgaggaac caaggggacc ttgcatttgc agcaagggtg     3480

gaaaactgga gaccagctaa ggttctaagc ccgtcttatc agaataaaaa caacattttt     3540

ctgatatctg aaatttctgc ctttctagcc ctcatagcaa accttaatcc caaatcagac     3600

caaaggccac aatatgtgct gggatgcttt tagaatgaaa ataagtacct gccccctcat     3660

gctcttgggg gcgggatgca cgcctgctgc agtcaggctg aagggtgttg attgacctgc     3720

ttgaaaaaca aaatccaggc tggtgagatg gctcagtggg taagagcacc cgactgctct     3780

tccaaaggtc cggattcttc cagtgataat catctgggct actgcttcat gatatggcaa     3840

gatattacat ttaggagaaa tcctcgaatg tatgcttgct ccttagtgat cttatgttgg     3900

agccttaagg tatggctaga gagatgaaac ttttcatgat cacgtttggc caaagcaaca     3960

ggatccgaaa ttaagtcttc tcctattaga gctctgtcaa tgcaatcatt gccttcagct     4020

aaaggtccag gaagaccaga gtgagattgt atgtggcc                             4058


<210>  11
<211>  1963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IL17F fragment

<400>  11
cggaaaatcc ccaaagtagg acatactttt ttccaaaagc ctgagagttg cccgcctgtg       60

ccaggaggta gtatgaagct tgacattggc atcatcaatg aaaaccagcg cgtttccatg      120

tcacgtaaca tcgagagccg ctccacctcc ccctggaatt acacgtaagt gcaaatgaga      180

ctgattttca cattctttgg aaaaatatgt taattcattc taatcataaa gtagaaaatg      240

tagaatacat agaaaaaata aaagggaaaa tcctcttaac aatgaaaatt tcactttacc      300

tgggagctca tatctttctt gttttggact aggttcacct ttgtggttga tggtcctaat      360

attttgcttc cacgttctca tagactttgt gcctttttct gcttcatgta gttctaggat      420

agaattcaca aattttcctg tgttggaaga gagggttctt taaagcagat tgcataatta      480

tctcctcatg aggataaatg ggaaacagaa aagtcggttt aaggagattc actcagatta      540

gacattatca tttaaggagt gggaatgagt ggaggagaaa ggccagtctg ggaaatggga      600

tgttaggtgg agaccttcag ggtacagtct tgtaatttgg cattaagata caggttcttg      660

gaagaccaag cactccctca tactctccaa atgtaagtat caaagtagat tccagggaca      720

attgaagtgc ttctggggtt gtcacatagc ttctcatgtg agtgtgttat gagaaaacct      780

tgggacggta gtgccccctg cctcgaactg ggaagatatg gagagatcaa agaatgactt      840

ggacaagtcc agcttagcga gtggatgagt ttattaagac ttactatggg gcgccctagg      900

gccacagcag gacagatcta gagatccgct ctgcctccca tctctaagct gctcttaagc      960

gaattttctg gctctttgcc tactgtgtgt gtccaatggg actgttttcc ttggtaggtt     1020

ctcagatact ctctgagatg tttgggttct cagtggcctg ctccttggct gtgcatggtg     1080

gccttggctc actgcccgtc cttcagggtt cagacagtgg acacacaccc tcaagtaacc     1140

tggtgggggt cctgtcacac tacaagtgga atatgtacaa tggcaagctg gcaggataaa     1200

tgttgtggtc tttatgcctc caggcagagg ggcctattaa aggagaaatg gagagaaggt     1260

ctgagattca cagacctctg gggctgtggc tttcctttcc aagcagcagg ctctgtagac     1320

cgactagtga tggaagactg actagtgacg ttcaatctcc aggcagagaa taaagaattg     1380

taataataat aataataatg ccaatgaaag atctaatgtt aattgaatgc taacatttgt     1440

acagtggggt attttatatg tacttgtatc actgagtatt ctcaacagtt gcatgagaaa     1500

atggtatatg aaaatcccca tcttatagtt gaggaaactg aggcttagaa aggtaagcca     1560

ctgccagagg ctggtgtatg cttccaggct gtgtggctcc agaacctgtg ccacagccct     1620

gcagaactgc ctccctgcag gtgaacactc agtgctgtgg ggctctcatt cgctgtcttc     1680

ctcccccatg cctcaccatt gtgctttggc ttgctcctcc tgcagtgtca cttgggaccc     1740

caaccggtac ccctcggaag ttgtacaggc ccagtgtagg aacttgggct gcatcaatgc     1800

tcaaggaaag gaagacatct ccatgaattc cgttcccatc cagcaagaga ccctggtcgt     1860

ccggaggaag caccaaggct gctctgtttc tttccagttg gagaaggtgc tggtgactgt     1920

tggctgcacc tgcgtcaccc ctgtcatcca ccatgtgcag taa                       1963


<210>  12
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the downstream in the A1 fragment and the mouse sequence

<400>  12
ctgcacctgc gtcacccctg tcatccacca tgtgcagtaa caacgctgca tacaaaaatc       60

agttgaagac ttccactgag                                                   80


<210>  13
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the Neo cassette and the mouse
       sequence

<400>  13
tcatatctgc tttaggtcct gccttaagtt cctgccaaag gatatcgaat tccgaagttc       60

ctattctcta gaaagtatag                                                   80


<210>  14
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  downstream connection between the Neo cassette and the mouse 
       sequence

<400>  14
gtataggaac ttcatcagtc aggtacataa tggtggatcc cttctctcca tgatggaact       60

tgtaaacgta acaattccat                                                   80


<210>  15
<211>  1178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the modified humanized mouse IL17F

<400>  15
gacataccca ggaagacata cttagaagaa agtacttcct gagggaagaa gcagccattg       60

gagaaaccag catgaagtgc acccgtgaaa cagccatggt caagtctttg ctactgttga      120

tgttgggact tgccattctg agggaggtag cagctcggaa aatccccaaa gtaggacata      180

cttttttcca aaagcctgag agttgcccgc ctgtgccagg aggtagtatg aagcttgaca      240

ttggcatcat caatgaaaac cagcgcgttt ccatgtcacg taacatcgag agccgctcca      300

cctccccctg gaattacact gtcacttggg accccaaccg gtacccctcg gaagttgtac      360

aggcccagtg taggaacttg ggctgcatca atgctcaagg aaaggaagac atctccatga      420

attccgttcc catccagcaa gagaccctgg tcgtccggag gaagcaccaa ggctgctctg      480

tttctttcca gttggagaag gtgctggtga ctgttggctg cacctgcgtc acccctgtca      540

tccaccatgt gcagtaacaa cgctgcatac aaaaatcagt tgaagacttc cactgagaaa      600

aagcctcctt ttatccagag ctctgtgtga agcccgatct ccaagtcttt atgctttcta      660

ggactctcag taaggtgtgc atggcattct tgcagctctg cagtagatat agcttgaact      720

ttctggcttg ctttagaatt gttaccagtc ctggtgtgtt cccaatgcct cacttaaact      780

cctaaaaaca aaggtaaatg aaggcaccct tggcccagtc tctttgtgtt agatgatgac      840

cacagttctt gtctgtcaag actgtcactt tgatgcagta ccattcttgt agagttcaat      900

gaaatgctca tatttgtgat ggaaagaaaa caaacataat cagaatgcat gggaggaggc      960

ctgtgtagca ggggctggac tggcaaggaa gaagcacaca tggtatgtgt gtttttagag     1020

aaaaatttgg taaatataaa tgaagttggc ataaactatt atatatttat gttggtaggg     1080

gaactataca tatatttatg acctattgat tatatatcaa tttagtagaa aattaatata     1140

tccattaatt atataataaa atatttttaa ttcaaaaa                             1178


<210>  16
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein sequence of the modified humanized mouse IL17F

<400>  16

Met Lys Cys Thr Arg Glu Thr Ala Met Val Lys Ser Leu Leu Leu Leu 
1               5                   10                  15      


Met Leu Gly Leu Ala Ile Leu Arg Glu Val Ala Ala Arg Lys Ile Pro 
            20                  25                  30          


Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro Pro Val 
        35                  40                  45              


Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu Asn Gln 
    50                  55                  60                  


Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser Pro Trp 
65                  70                  75                  80  


Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu Val Val 
                85                  90                  95      


Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly Lys Glu 
            100                 105                 110         


Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu Val Val 
        115                 120                 125             


Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu Lys Val 
    130                 135                 140                 


Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His His Val 
145                 150                 155                 160 


Gln 
    


<210>  17
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ccgaactata gtgactttca gtcttgct                                          28


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
atttatcctg ccagcttgcc attgt                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gagaaaacct tgggacggta gtgcc                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
ttagacaagg gagccaagtt cctgc                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
tctctgttca gctcccaaga agtca                                             25


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
atgcccacgg tccagaaata ctat                                              24


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
ctcattgcat agcgtcatgt gaca                                              24


<210>  24
<211>  1567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  24
acatccatcc catgcacagg gtaacatcaa tacactgcca accgttgttg ccttgtggaa       60

ctactgcatg cttacaggga tctttgggat ttatgaggat gtaggaaacc aagtcattgt      120

gcggtgagtc ctataaatga attatggact ccacacagtt aactctagag ataatgcctg      180

aaaccacaac actgtggcct cgaggattag ctactcagtg aacgaatgac ttcagaggcg      240

aaggcatatg gctgctgatt atctggagac aaatctgttt catcctgcag cttgctttca      300

atgtattatc agtgatcgta gtccagcagg ctgactccat gacctctttg tttattctgc      360

atatttcttg cctccaggat gttgaaaaga acaggcaaat ctttaaatcc aacatgcaca      420

gtcactttcc ctacctacac agtgtgagcc tgaacaacac ggagcccaga aatgaaaagc      480

tcagccttag ctcttctgcc ttaccatggg ctttgttctt ccccaggaag gtgtgagcag      540

ggacggcaaa ggacatttgc acccaagggg agctgttgag gttttagctc ttcttgtgtt      600

tagagctcca ctgagcactt tgtgtgcgct agtaacagca gcgaaactga tttcagtgtt      660

agtacagaaa agatagattc tagagctaaa agaaatgggt tctgcactct gagtgatgcc      720

aggcgtcatc agtgtccctg cttctttcaa ttagcatgga taaatgaaat tttgctgtgc      780

ttagtttccc ataatccttt tactcaatga gcgtggcata actatactgg ttaatttaac      840

tgggctgccc tgttcattca cttccccact ctctcattca ttcagaaagt tttcatggac      900

caactatgct ctcgcaggaa gttaactctg agtctggtat gaacacagat atgacatctt      960

tagagaacag aaaaaatact tcttgagtga tacatgctaa aatctttatt atttaatgtt     1020

gataaatata cttttaaaaa aatatttatt gtatgtataa gagttcactg tttctgcctt     1080

tagacacacc agaagagggc attggatgcc attacagatg gttgtgagcc actatgtggt     1140

tgctgggaac tgaactcagg acctctagaa gagcaatcag tgctcttagc tgtggagcca     1200

ttcctccatc ccaataaata tacttctaat tgaattacat atgggacctt gacagtaggg     1260

tgaggtttgg tggaatgtcc cagagaaagg ttttgtggac tataaggccg gagataaact     1320

ccagagagct ttactcctga ccctttctgc tttgtatcct gataacatta aacacggcag     1380

ttctcattgc tagtgaacca tgaaaaaaaa aaaaaaaaag aaaccttgat cctgtaaagt     1440

gaccctatac agagttcaag tacattgccc accaccaggg ctctaacctg tggtaatctc     1500

tattttccag gtcaagtctt tgctactgtt gatgttggga cttgccattc tgagggaggt     1560

agcagct                                                               1567


<210>  25
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  25
caacgctgca tacaaaaatc agttgaagac ttccactgag aaaaagcctc cttttatcca       60

gagctctgtg tgaagcccga tctccaagtc tttatgcttt ctaggactct cagtaaggtg      120

tgcatggcat tcttgcagct ctgcagtaga tatagcttga actttctggc ttgctttaga      180

attgttacca gtcctggtgt gttcccaatg cctcacttaa actcctaaaa acaaaggtaa      240

atgaaggcac ccttggccca gtctctttgt gttagatgat gaccacagtt cttgtctgtc      300

aagactgtca ctttgatgca gtaccattct tgtagagttc aatgaaatgc tcatatttgt      360

gatggaaaga aaacaaacat aatcagaatg catgggagga ggcctgtgta gcaggggctg      420

gactggcaag gaagaagcac acatggtatg tgtgttttta gagaaaaatt tggtaaatat      480

aaatgaagtt ggcataaact attatatatt tatgttggta ggggaactat acatatattt      540

atgacctatt gattatatat caatttagta gaaaattaat atatccatta attatataat      600

aaaatatttt taattcaaaa atatttgaag tctgtgctgg ttagtttttg ttaatgtggt      660

atatacttga gccacctggc aagaggaaag cttagttggg gaattgcccc tatcagattg      720

gtctctgggc atgtctgggg ggcattttct tggttaatgg ttgtttcggg agggcctagc      780

ccattgtggg tggtgcctgt tgtggggagg tggtcctgag ttatataaga aaacaagctg      840

ggcagaccat ggagaggaag ctactgagca gcactctgtc atcatatctg ctttaggtcc      900

tgccttaagt tcctgccaaa gcttctctcc atgatggaac ttgtaaacgt aacaattcca      960

ttcccctcta agttgttttt gttcatggtg tttaacatgg cagcacagaa agcagctaga     1020

caagtatttg cttctgcctt cagcttgaac tccaagactt tacaaccctc aacattttga     1080

acatctgtat atcatttgtt tttccaaatt tcctcctcag agctcccatg ttagagttat     1140

tgttattaat ggaactgagg tcccgttaca cttagaaaga gagttaaggg aaatggtgca     1200

aatggaattc aagtgtgggg ccagcatgtt acacttccag ccttctggcc acatcttgtt     1260

acaaagcaaa cacttactgt ccactttgct agcttctgga gttatgatgt ggagaaagat     1320

gtacgtagaa gagccactgt attggcagta gccaccccca gaaccctgtc attagggcca     1380

catggttcct ttgccttctt c                                               1401


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  26
agcggttctg gaattcacgt ggg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  27
gctcggaaga accccaaagc agg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  28
cgaatcttca accaaaacca ggg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  29
atggggaact ggagcggttc tgg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  30
acagtgttat cctccagggg agg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  31
ctctcacagt gttatcctcc agg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  32
tgggaactgt cctcccctgg agg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  33
ttcccagcct tctgcaaggc agg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  34
agcgttgtca ggccgcttgg tgg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  35
tgcagcgttg tcaggccgct tgg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  36
caggccgctt ggtggacaat ggg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  37
tcaggccgct tggtggacaa tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  38
gtggacaatg ggcttgacac agg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  39
agggctgttc taattccttc agg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  40
gaaggaatta gaacagccct ggg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  41
gagaagatgc tcctaaaagt tgg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-4 upstream sequence

<400>  42
atggggaact ggagcggttc tgg                                               23


<210>  43
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-4 forward oligonucleotide

<400>  43
taggatgggg aactggagcg gttctgg                                           27


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-4 downstream sequence

<400>  44
ccagaaccgc tccagttcca t                                                 21


<210>  45
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-4 reverse oligonucleotide

<400>  45
aaacccagaa ccgctccagt tccat                                             25


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-9 upstream sequence

<400>  46
agcgttgtca ggccgcttgg tgg                                               23


<210>  47
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-9 forward oligonucleotide

<400>  47
taggagcgtt gtcaggccgc ttggtgg                                           27


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-9 downstream sequence

<400>  48
ccaccaagcg gcctgacaac gct                                               23


<210>  49
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA-9 reverse oligonucleotide

<400>  49
aaacccacca agcggcctga caacgct                                           27


<210>  50
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA fragment containing the T7 promoter and sgRNA scaffold

<400>  50
gaattctaat acgactcact atagggggtc ttcgagaaga cctgttttag agctagaaat       60

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      120

tttaaaggat cc                                                          132


<210>  51
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
gcatcatcaa tgaaaaccag cgcgt                                             25


<210>  52
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
agaaccctct cttccaacac aggaa                                             25


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
cctatctggg agttggtttg gggtc                                             25


<210>  54
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  54
gaactcggag cctgcagatc caatc                                             25


<210>  55
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  corresponding mRNA sequence of the human IL17F DNA sequence in 
       the A1 fragment

<400>  55
cggaaaatcc ccaaagtagg acatactttt ttccaaaagc ctgagagttg cccgcctgtg       60

ccaggaggta gtatgaagct tgacattggc atcatcaatg aaaaccagcg cgtttccatg      120

tcacgtaaca tcgagagccg ctccacctcc ccctggaatt acactgtcac ttgggacccc      180

aaccggtacc cctcggaagt tgtacaggcc cagtgtagga acttgggctg catcaatgct      240

caaggaaagg aagacatctc catgaattcc gttcccatcc agcaagagac cctggtcgtc      300

cggaggaagc accaaggctg ctctgtttct ttccagttgg agaaggtgct ggtgactgtt      360

ggctgcacct gcgtcacccc tgtcatccac catgtgcagt aa                         402


<210>  56
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the upstream of the human IL17F DNA sequence 
       in the A1 fragment and the mouse gene

<400>  56
gtcaagtctt tgctactgtt gatgttggga cttgccattc tgagggaggt agcagctcgg       60

aaaatcccca aagtaggaca tacttttttc caaaagcctg ag                         102


<210>  57
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  57
actgttgatg ttgggacttg ccatt                                             25


<210>  58
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
tactgcacat ggtggatgac aggg                                              24


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  59
acccgtgaaa cagccatggt caa                                               23


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
agtcaccagc accttctcca actg                                              24


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
tcaggccgct tggtggacaa tg                                                22


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
acacaggtgc agccaacttt tagg                                              24


<210>  63
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
acctcattgg tgtcactgct actgc                                             25


<210>  64
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
attgcggtgg agattccaag gtgag                                             25


<210>  65
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
aggcaggaat cacaatccca cgaaa                                             25


<210>  66
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
tcctcattgc ggtggagatt ccaag                                             25


<210>  67
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  67
tccagggaga gcttcatctg tgtct                                             25


<210>  68
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  68
gctcactttt gcgccaaggg agtta                                             25


<210>  69
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
tccaaacact gaggccaagg acttc                                             25


<210>  70
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
accagcatct tctcgaccct gaaag                                             25


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  71
tcaccatctt ccaggagcga ga                                                22


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  72
gaaggccatg ccagtgagct t                                                 21


<210>  73
<211>  158
<212>  PRT
<213>  Rattus norvegicus

<400>  73

Met Ser Pro Arg Arg Ile Pro Ser Met Cys Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Asn Leu Glu Ala Thr Val Lys Ala Ala Val Leu Ile Pro Gln Ser 
            20                  25                  30          


Ser Val Cys Pro Asn Ala Glu Ala Asn Asn Phe Leu Gln Asn Val Lys 
        35                  40                  45              


Val Asn Leu Lys Val Leu Asn Ser Leu Ser Ser Lys Ala Ser Ser Arg 
    50                  55                  60                  


Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu Ser 
65                  70                  75                  80  


Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
                85                  90                  95      


Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
            100                 105                 110         


Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
        115                 120                 125             


Pro Glu Lys Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
    130                 135                 140                 


Val Gly Cys Thr Cys Val Ser Ser Ile Val Arg His Ala Ser 
145                 150                 155             


<210>  74
<211>  161
<212>  PRT
<213>  Rattus norvegicus

<400>  74

Met Lys Gly Ser Cys Glu Thr Thr Met Val Lys Ser Leu Leu Leu Leu 
1               5                   10                  15      


Met Leu Gly Phe Ala Ile Ile Ser Ser Gly Ala Ala Arg Arg Asn Pro 
            20                  25                  30          


Lys Val Gly Leu Ser Ala Leu Gln Lys Ala Gly Asn Cys Pro Pro Leu 
        35                  40                  45              


Glu Asp Asn Ser Val Arg Val Asp Ile Arg Ile Phe Asn Gln Asn Gln 
    50                  55                  60                  


Gly Ile Ser Val Pro Arg Asp Phe Gln Asn Arg Ser Ser Ser Pro Trp 
65                  70                  75                  80  


Asp Tyr Asn Ile Thr Arg Asp Pro Asp Arg Phe Pro Ser Glu Ile Ala 
                85                  90                  95      


Glu Ala Gln Cys Arg His Ser Gly Cys Ile Asn Ala Gln Gly Gln Glu 
            100                 105                 110         


Asp Gly Ser Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu Val Leu 
        115                 120                 125             


Arg Arg Glu Pro Gln Gly Cys Ser Asn Ser Phe Arg Leu Glu Lys Met 
    130                 135                 140                 


Leu Ile Lys Val Gly Cys Thr Cys Val Thr Pro Ile Val His His Ala 
145                 150                 155                 160 


Ala 
    


