                         SEQUENCE LISTING

<110>  NANJING LEGEND BIOTECH CO., LTD.
 
<120>  MULTISPECIFIC CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

<130>  14651-028-228

<140>
<141>

<150>  PCT/CN2020/102470
<151>  2020-07-16

<160>  323   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-273, VHH-283, huVHH-253, huVHH-256

<400>  1

Gly Arg Thr Phe Ser Ser Tyr Asn Met Gly 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-273, huVHH-256

<400>  2

Val Val Asp Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-273, huVHH-253, huVHH-256

<400>  3

Arg Val Gln Tyr Gly Ser Ser Trp Ser Gly Asp Tyr 
1               5                   10          


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-273, VHH-283, huVHH-253, huVHH-256

<400>  4

Gly Arg Thr Phe Ser Ser Tyr Asn 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-273

<400>  5

Val Val Asp Trp Ser Gly Gly Ser Pro 
1               5                   


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-273, huVHH-253, huVHH-256

<400>  6

Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser Gly Asp Tyr 
1               5                   10                  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-283

<400>  7

Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Ser Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-283, VHH-313, and huVHH-260

<400>  8

Pro Ile Glu Tyr Gly Ser Ser Trp Ser Ala Asp Tyr 
1               5                   10          


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-283, VHH-313, and huVHH-260

<400>  9

Ile Ser Trp Ser Gly Gly Ser Pro 
1               5               


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-283, VHH-313, and huVHH-260

<400>  10

Ala Ala Pro Ile Glu Tyr Gly Ser Ser Trp Ser Ala Asp Tyr 
1               5                   10                  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-313 and huVHH-260

<400>  11

Gly Arg Thr Ile Ser Ser Tyr Ser Met Gly 
1               5                   10  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-313 and huVHH-260

<400>  12

Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-313 and huVHH-260

<400>  13

Gly Arg Thr Ile Ser Ser Tyr Ser 
1               5               


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-440 and VHH-653

<400>  14

Ala Tyr Ile Arg Val Phe Tyr Leu Met Gly 
1               5                   10  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-440

<400>  15

Arg Val Thr Ala Asp Gly Phe Thr Asn His Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-440, VHH-466, VHH-653, huVHH-836, huVHH-840, 
       huVHH-843, and huVHH-846

<400>  16

Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr 
1               5                   10  


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-440 and VHH-653

<400>  17

Ala Tyr Ile Arg Val Phe Tyr Leu 
1               5               


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-440

<400>  18

Val Thr Ala Asp Gly Phe Thr 
1               5           


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-440, VHH-466, VHH-653, huVHH-836, huVHH-840, 
       huVHH-843, and huVHH-846

<400>  19

Ala Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr 
1               5                   10          


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-466, huVHH-836, huVHH-840, huVHH-843, and 
       huVHH-846

<400>  20

Ala Asp Ile Arg Leu Phe Tyr Leu Met Gly 
1               5                   10  


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-466

<400>  21

Arg Val Asn Ala Asp Asp Ser Ile Asn Tyr Val Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-466, huVHH-836, huVHH-840, huVHH-843, and 
       huVHH-846

<400>  22

Ala Asp Ile Arg Leu Phe Tyr Leu 
1               5               


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-466, huVHH-840, and huVHH-843, huVHH-846

<400>  23

Val Asn Ala Asp Asp Ser Ile 
1               5           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-496, huVHH-746, and huVHH-750, huVHH-753

<400>  24

Gly Phe Thr Phe Ser Asn Tyr Pro Met Thr 
1               5                   10  


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-496, huVHH-746, huVHH-750, and huVHH-753

<400>  25

Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-496, huVHH-746, huVHH-750, and huVHH-753

<400>  26

Trp Asp Arg Thr Leu 
1               5   


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-496, huVHH-746, huVHH-750, and huVHH-753

<400>  27

Gly Phe Thr Phe Ser Asn Tyr Pro 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-496, huVHH-746, huVHH-750, and huVHH-753

<400>  28

Ile Thr Ser Gly Gly Asp Arg Pro 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-496, huVHH-746, huVHH-750, and huVHH-753

<400>  29

Ala Thr Trp Asp Arg Thr Leu 
1               5           


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-653

<400>  30

Arg Val Asn Ala Asp Gly Ile Thr Asn His Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-653

<400>  31

Val Asn Ala Asp Gly Ile Thr 
1               5           


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of huVHH-253

<400>  32

Ala Val Asp Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of huVHH-253, huVHH-256

<400>  33

Val Asp Trp Ser Gly Gly Ser Pro 
1               5               


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of huVHH-836

<400>  34

Arg Val Asn Ala Asp Asp Ser Ile Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of huVHH-836

<400>  35

Val Asn Ala Asp Asp Ser Ile Ser 
1               5               


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of huVHH-840

<400>  36

Phe Val Asn Ala Asp Asp Ser Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of huVHH-843

<400>  37

Arg Val Asn Ala Asp Asp Ser Ile Asn Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of huVHH-846

<400>  38

Phe Val Asn Ala Asp Asp Ser Ile Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  39
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-273 (amino acid)

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  40
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-283 (amino acid)

<400>  40

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Ser Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Ile Glu Tyr Gly Ser Ser Trp Ser Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  41
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-313 (amino acid)

<400>  41

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Ser Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Arg Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Ile Glu Tyr Gly Ser Ser Trp Ser Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  42
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-440 (amino acid)

<400>  42

Gln Val His Leu Met Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Ala Tyr Ile Arg Val Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
        35                  40                  45              


Ala Arg Val Thr Ala Asp Gly Phe Thr Asn His Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Met Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  43
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-466 (amino acid)

<400>  43

Gln Val His Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Ala Asp Ile Arg Leu Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
        35                  40                  45              


Ala Arg Val Asn Ala Asp Asp Ser Ile Asn Tyr Val Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  44
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-496 (amino acid)

<400>  44

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              


Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-653 (amino acid)

<400>  45

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Ala Tyr Ile Arg Val Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
        35                  40                  45              


Ala Arg Val Asn Ala Asp Gly Ile Thr Asn His Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-253 (amino acid)

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Val Asp Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-256 (amino acid)

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-260 (amino acid)

<400>  48

Asp Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Ser Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Ile Glu Tyr Gly Ser Ser Trp Ser Ala Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  49
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-746 (amino acid)

<400>  49

Gln Ile Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Pro Met Thr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              


Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Asp Arg Thr Leu Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  50
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-750 (amino acid)

<400>  50

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              


Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  51
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-753 (amino acid)

<400>  51

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
        35                  40                  45              


Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-836 (amino acid)

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Asp Ile Arg Leu Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ala Arg Val Asn Ala Asp Asp Ser Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  53
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-840 (amino acid)

<400>  53

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Asp Ile Arg Leu Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Val Asn Ala Asp Asp Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  54
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-843 (amino acid)

<400>  54

Gln Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Ala Asp Ile Arg Leu Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ala Arg Val Asn Ala Asp Asp Ser Ile Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  55
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-846 (amino acid)

<400>  55

Gln Val His Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Ala Asp Ile Arg Leu Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Val Asn Ala Asp Asp Ser Ile Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  56
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-273 (nucleic acid)

<400>  56
gaagtccagc tggtggaatc cgggggaggc ctggtgcagg caggaggctc cctgcggctg       60

tcttgcgcag caagcggaag gaccttcagc tcctacaaca tgggctggtt taggcaggca      120

ccaggcaagg agagggagtt cgtggcagtg gtggactggt ctggaggcag cccttactat      180

gccgattccg tgaagggccg gtttaccatc agccgggaca acggcaagaa tacagtgtat      240

ctgcagatga acagcctgaa gcccgaggat acagccgtgt actattgtgc cggccgggtg      300

cagtacgggt caagctggtc tggggattat tgggggcagg ggactcaggt cactgtctca      360

tca                                                                    363


<210>  57
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-283 (nucleic acid)

<400>  57
caggtcaaac tggaggaatc tgggggaggc agcgtgcagg caggaggcag cctgcggctg       60

tcctgcgccg cctctggcag gaccttcagc tcctacaaca tgggctggtt taggcaggca      120

ccaggcaagg agagggagtt cgtggcagca atctcctggt ctggaggcag cccctactat      180

gcctctagcg tgcggggccg gttcaccatc tcccgggaca acgccaagaa tacagtgtat      240

ctgcagatga acagcctgaa gcccgaggat acagccgtgt actattgtgc cgcccctatc      300

gagtacggct cttcttggtc agcagattat tggggacagg gcactcaggt cacagtctca      360

tca                                                                    363


<210>  58
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-313 (nucleic acid)

<400>  58
gatgtgcagc tggtggagag cggcggcggg ttggtgcaag ccggtggttc gctgcggttg       60

tcatgcgccg cttccggacg tacaatctct agctactcca tgggctggtt ccgccaggcc      120

cctggtaagg agcgcaggtt tgtcgcggcc atctcctggt ctggagggtc gccctattac      180

gcggacagcg tgaagggccg cttcaccatc agccgtgaca acgccaagaa cacggtttac      240

ctgcagatga actccctcaa acctgaagac accgccgtgt actactgtgc tgcaccaatt      300

gagtacggct ccagttggtc tgcggactat tggggccagg gcacccaggt caccgtgtcc      360

tct                                                                    363


<210>  59
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-440 (nucleic acid)

<400>  59
caggtccacc tgatggagag cggaggcggc tccgtgcagg ccggaggtag tctgcgcctg       60

tcatgccagg cctccgccta cattcgagtg ttctacctga tgggctggtt ccgccaggcc      120

ccggggaagg agcgcgagga ggtggctcgt gtcactgcgg acggcttcac caaccatgca      180

gcttctgtga agggccgctt caccatctcc aaggacaacg cgaagaacac gctgtacttg      240

cagatggatt ctatgaaaag cgaagacact gccgtgtact actgtgccgc tgggcggacc      300

tggaactccg gttttgagta ttggggccag ggcacccagg tcaccgtgtc gtcc            354


<210>  60
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-466 (nucleic acid)

<400>  60
caggtccact tggtggagag cggtggaggc tccgtgcagg ccggaggttc tctccgtctc       60

tcatgccagg cctccgcgga catccgcctg ttttacctga tgggctggtt ccgccaagca      120

cccgggaagg agcgcgagga ggtggctcgg gttaacgcgg atgacagcat taactacgtg      180

gcgagtgtaa agggccgctt caccatctcc aaggacaacg ccaagaacac gctgtacttg      240

cagatggatt ctcttaaacc ggaagacacc gccacttact actgtgctgc tgggcgaacc      300

tggaactccg gcttcgagta ttggggccag ggcacccagg tcaccgtgag ctcg            354


<210>  61
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-496 (nucleic acid)

<400>  61
cagatccagc tggtggagag tggaggcggc ttggtgcagc cagggggctc cctacgcctg       60

tcatgcgctg cttctggctt cacgttcagc aactacccga tgacctggct ccgccaggcc      120

cccgggaaag gcctcgagag cgtgtccgac atcacctccg gtggtgatcg gccctattac      180

gcggactcgg tgaagggcag gtttacaatt tctcgcgaca acgccaagaa tatgctgtac      240

ctggagatga actccctgaa gactgaagac accgccgtgt actactgtgc cacctgggat      300

cgcaccctga cgggacaagg cacccaggtc accgttagct cg                         342


<210>  62
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-653 (nucleic acid)

<400>  62
caggtgaagc tggtggagag cggtgggggc tccgtgcagg ccggaggtag ccttcgcctg       60

tcatgccagg cctccgccta cattcgggtg ttttacctga tgggctggtt ccgccaggcc      120

ccggggaagg agcgcgagga ggtggcacga gtcaacgcgg acggcatcac caaccatgca      180

gcttccgtaa aaggccgctt caccatctcc aaggacaacg ccaagaacac gctatacctc      240

cagatggatt ctctgaagcc cgaggacacc gccgtgtact actgtgctgc gggacgtact      300

tggaactccg gcttcgaata ttggggccag ggcacccagg tcactgtcag ttcc            354


<210>  63
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-253 (nucleic acid)

<400>  63
gaggtgcagc tggtggagag cggcggcggt ttggtgcagc caggaggctc cctccgcctg       60

tcatgcgccg cttccggccg caccttcagc agctacaaca tgggctggtt ccgccaggcc      120

cccggcaaag gcctggagtg ggtcgcggcc gtggattggt ctggcggttc cccctattac      180

gcggactccg tgaagggccg cttcaccatc tcccgcgaca actccaagaa cacggtgtac      240

ctgcagatga actctctgcg cgccgaggac accgccgtct actactgtgc cggccgagtg      300

cagtacggct ccagttggtc tggggactat tggggccagg gcaccctggt gaccgtgtcg      360

tcc                                                                    363


<210>  64
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-256 (nucleic acid)

<400>  64
gaggtgcagc tggtggagag cggaggcggt ttggtgcagc cagggggttc tctgcgcctg       60

agctgtgctg cttccggtcg tacgttcagc agctacaaca tgggctggtt ccgccaggcc      120

cccggcaaag gcctggagtt cgtcgccgtg gtggactggt ctggcggctc cccctattac      180

gcggactccg tgaagggccg cttcaccatc tcccgcgaca actccaagaa cacggtgtac      240

ctgcagatgt cttctcttcg cgccgaggac accgccgtct actactgcgc cggccgagtg      300

cagtacggct ccagttggtc tggtgattat tggggccagg gcaccctggt gaccgtgtcg      360

tcc                                                                    363


<210>  65
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-260 (nucleic acid)

<400>  65
gacgtgcagc tgctggagag cggaggcggg ctggtgcagc cagggggttc tcttcgcctg       60

tcatgcgccg cttccggtcg caccatctct agctactcca tgggctggtt ccgccaggcc      120

cccggcaaag gcctcgagtt cgtcgcggcc atcagttggt ctggcggctc cccctattac      180

gcggactccg tgaagggccg cttcaccatc tcccgcgaca acgccaagaa cacggtctac      240

ctgcagatga actccctgcg cgccgaggac accgccgtgt actactgtgc tgctcctatt      300

gagtacggct ccagttggtc tgcggactat tggggccagg gcaccctggt caccgtgtcg      360

tcc                                                                    363


<210>  66
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-746 (nucleic acid)

<400>  66
cagatccagc tgctggagag tggcggcggg ctggtgcagc cgggaggctc cctgcgcctg       60

tcatgcgccg cttccggctt cacgttcagc aactacccaa tgacctggat ccgccaggcc      120

cccggcaaag gcctcgagag cgtgtccgac atcacctccg gtggtgatag gccctattac      180

gcggactccg tgaagggccg cttcaccatc tctcgcgaca acgccaagaa catgctgtac      240

ctgcagatga actccctccg cgccgaggac accgccgtgt actactgtgc cacctgggac      300

cgcacccttt ggggccaggg caccatggtg accgtgagct cc                         342


<210>  67
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-750 (nucleic acid)

<400>  67
cagatccagc tggtggagag cggaggcggt ttggtgcagc cgggcggctc cctgcgcctg       60

agctgtgctg cttccggctt cacattttca aattatccaa tgacctggct ccgccaggcc      120

cccggcaagg gcctggagtc cgtgtccgac atcacctccg gtggggacag gccctattac      180

gcggacagcg tcaaaggccg cttcaccatc tctcgcgaca acgccaagaa catgctgtac      240

ctgcagatga actccttacg cgccgaggac accgccgtgt actactgcgc cacctgggac      300

cgcaccctga ccggccaggg caccatggtg accgtgagct cc                         342


<210>  68
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-753 (nucleic acid)

<400>  68
cagatccagc tggtggagag cggcggcggt ttggtgcagc cgggaggctc cctgcgcctg       60

tcatgcgccg cttccggctt caccttttca aattacccaa tgacctggct ccgccaggcc      120

cccggcaaag gcctggagtc cgtgtccgac atcacctccg gtggggacag gccctattac      180

gcggacagcg tgaagggccg cttcaccatc tctcgcgaca acgccaagaa catgctttac      240

ctgcagatga actccttacg cgccgaggac accgccgtgt actactgtgc cacctgggac      300

cgcaccctca ctggacaggg caccctggtc accgtgtcgt cc                         342


<210>  69
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-836 (nucleic acid)

<400>  69
gaggtgcagc tggtggagag cggtggcggt ctggtgcagc cgggaggctc cttgcgtcta       60

tcatgcgccg cttccgcgga catccgcctg ttttacctga tgggctggtt ccgccaggcc      120

cccgggaaag ggttggtttg ggtcgcccga gtcaacgcgg atgacagcat ttcttacgcg      180

gatagtgtga agggccgctt caccatctcc cgcgacaacg ccaagaacac gctctacctc      240

cagatgaact ccctgcgcgc cgaggacacc gccgtatact actgtgctgc aggacggacc      300

tggaactccg gcttcgagta ctggggccag ggcactcttg tcaccgtgag ctcg            354


<210>  70
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-840 (nucleic acid)

<400>  70
caggtgcagc tgcaggagag cggaggaggt gtggtgcagc caggcggctc cttgcgcctg       60

tcatgcgccg ctagtgcgga catccgactc ttttacctga tgggctggtt ccgccaggcc      120

ccggggaaag gtctcgagtg ggtcgccttc gtgaacgcag atgacagcat ttactacgcg      180

gattccgtaa agggccgctt caccatctct cgggacaact ccaagaacac gctgtacctc      240

cagatgaaca gcctacgtgc cgaggacact gccgtgtact actgtgccgc tgggcgcacc      300

tggaactccg gcttcgagta ctggggccaa ggcaccctgg tgaccgtgtc gtct            354


<210>  71
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-843 (nucleic acid)

<400>  71
caggtccact tggtggagag cggaggtggt ctggtgcagc cagggggctc cctacgcctg       60

tcatgccagg cctccgcgga catccgactc ttttacctaa tgggctggtt ccgccaggcc      120

cccgggaaag gccttgtttg ggtcgcacgg gtcaacgcgg atgacagcat taactacgtg      180

gattctgtga agggccgctt caccatctcc aaggacaacg ccaagaacac gctgtacctg      240

cagatgaact ccctgcgcgc cgaggacacc gccgtgtact actgtgctgc tggacgtacc      300

tggaactccg gcttcgagta ttggggccag ggcaccctgg taacagtgtc gtcg            354


<210>  72
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-846 (nucleic acid)

<400>  72
caggtccact tgcaggagag cggcgggggt gtggtgcagc cgggaggctc ccttcgtctc       60

tcatgccaag cctcggcgga catccggctt ttttacctga tgggctggtt ccgccaggcc      120

cccgggaagg gactggagtg ggttgccttc gtgaacgctg atgacagcat taactacgcg      180

gattccgtga agggccgctt caccatctct aaggacaaca gcaaaaacac tctgtacctc      240

cagatgaact ccctgcgcgc tgaagacacc gccgtgtact actgtgctgc aggtcgcacc      300

tggaactccg gcttcgagta ttggggccag ggcaccctgg tgacggtgtc cagt            354


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-083, huVHH-773, huVHH-776, VHH-131 (Kabat)

<400>  73

Gly Asn Ile Asn Ser Arg Asn Cys Met Gly 
1               5                   10  


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-083, huVHH-773, huVHH-776 (Kabat)

<400>  74

Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of VHH-083, huVHH-773, huVHH-776, VHH-131 (Kabat)

<400>  75

Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn 
1               5                   10                  15      


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-083, huVHH-773, huVHH-776, VHH-131 (IMGT)

<400>  76

Gly Asn Ile Asn Ser Arg Asn Cys 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-083, huVHH-773, huVHH-776, VHH-131 (IMGT)

<400>  77

Ile Gly Gln Val Thr Gly Arg Ser 
1               5               


<210>  78
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of VHH-083, huVHH-773, huVHH-776, VHH-131 (IMGT)

<400>  78

Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr 
1               5                   10                  15      


Arg Asn 
        


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-111 (Kabat)

<400>  79

Gly Asp Thr Leu Ser Asn Lys Trp Met Gly 
1               5                   10  


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-111 (Kabat)

<400>  80

Thr Ile Arg Thr Asp His Ala Gly Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of VHH-111 (Kabat)

<400>  81

Ser Tyr Ser Gly Ala Thr Thr Phe Arg Tyr 
1               5                   10  


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-111 (IMGT)

<400>  82

Gly Asp Thr Leu Ser Asn Lys Trp 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-111 (IMGT)

<400>  83

Ile Arg Thr Asp His Ala Gly Thr 
1               5               


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of VHH-111 (IMGT)

<400>  84

Ala Ala Ser Tyr Ser Gly Ala Thr Thr Phe Arg Tyr 
1               5                   10          


<210>  85
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-083 (amino acid)

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr 
            100                 105                 110         


Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  86
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-111 (amino acid)

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Leu Ser Asn Lys 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Arg Thr Asp His Ala Gly Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Met Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ser Tyr Ser Gly Ala Thr Thr Phe Arg Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  87
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-773 (amino acid)

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Asn Ser Arg Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr 
            100                 105                 110         


Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  88
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-776 (amino acid)

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Asn Ser Arg Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr 
            100                 105                 110         


Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  89
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-083 (nucleic acid)

<400>  89
caggtgcagc tggtggagag cggaggtggc tctgtgcagg ctggtgggtc gctcaggctg       60

tcatgcgggg cgtccggcaa cattaactcc cgcaactgca tgggctggtt ccgtcaagcc      120

ccaggcaagg agcgcgaggg cgtagccgct atcggtcagg tcaccggccg cagctactac      180

gtggattctg ttaaaggccg cttcaccatc tcgttggaca acgcgaagaa cacgctgtac      240

ctgcagatga acacactgaa gcccgaagac accgccatgt attactgtgc tgcagccccg      300

gggtgtctgc tgtccgctct gcgctccgcg gactaccgga attggggcca gggcacccag      360

gtcaccgtgt ccagt                                                       375


<210>  90
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-111 (nucleic acid)

<400>  90
gaggtgcagc tggtggagag cggaggggga tccgtgcaag ccggcggctc cttgcgcctg       60

tcatgcgccg cttccggtga tactcttagc aacaaatgga tgggctggtt ccgccaggcc      120

cccggcaagg agcgcgattg ggtcgcgacg attcgtaccg accacgccgg gacctacgcg      180

gacagtgtga agggccgctt caccatctcg cgggacaact ttaagaatat gatctacctg      240

cagatgaaca acctgaagcc tgaagacacc gccatgtatt actgtgctgc tagctactcc      300

ggtgcaacca ccttcagata ctggggccag ggcacccagg tcaccgtttc ttct            354


<210>  91
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-773 (nucleic acid)

<400>  91
caggtgcagc tggtggagag cggaggcggg ctggtgcagc cgggcggctc cctccgcctg       60

tcatgcgccg cttccggcaa cattaattcc cgcaactgca tgggctggtt ccgccaggcc      120

cccggcaagg gcagggaggg cgtggcggcc atcggtcagg tcaccggccg cagctattac      180

gtggattctg tgaagggacg cttcaccatc tctctggaca actccaagaa cacgctgtac      240

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgtgc cgcggcgcca      300

gggtgcctgc tgtccgccct gcgctcggcg gactacagga actggggcca gggcaccctg      360

gttaccgtgt cctcc                                                       375


<210>  92
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-776 (nucleic acid)

<400>  92
caggtgcagc tggtggagag cggaggcggt gtggtgcagc cagggcgatc tcttcgcctg       60

tcatgcgccg cttccggcaa cattaattcc cgcaactgca tgggctggtt ccgccaggcc      120

cccggcaaag gcagggaggg cgtggcggcc atcggtcagg tcaccggccg cagctattac      180

gtggattctg tgaagggccg cttcaccatc tctctggaca actccaagaa cacgctgtac      240

ctgcagatga acagcctgcg cgccgaggac accgccgtgt actactgtgc tgcggctccc      300

gggtgcctgc tgtccgccct gcgctcggcg gactaccgga actggggcca gggcaccctg      360

gtgaccgtgt cctcc                                                       375


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR1 (Kabat)

<400>  93

Gly Gly Ser Phe Arg Ser Val Ser Met Gly 
1               5                   10  


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR2 (Kabat)

<400>  94

Leu Leu Thr Ala Gly Met Arg Ser Asp Val Tyr Ala Asp Pro Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR3 (Kabat)

<400>  95

Gly Arg Arg Phe Arg Ser Asp His Trp Tyr Leu Asp Asp Tyr Glu Tyr 
1               5                   10                  15      


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR1 (IMGT)

<400>  96

Gly Gly Ser Phe Arg Ser Val Ser 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR2 (IMGT)

<400>  97

Leu Thr Ala Gly Met Arg Ser Asp 
1               5               


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR3 (IMGT)

<400>  98

Ala Ala Gly Arg Arg Phe Arg Ser Asp His Trp Tyr Leu Asp Asp Tyr 
1               5                   10                  15      


Glu Tyr 
        


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 and huVHH-077 CDR1 (Kabat)

<400>  99

Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn 
1               5                   10          


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 and huVHH-077 CDR2 (Kabat)

<400>  100

Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser 
1               5                   10                  15  


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 and huVHH-077 CDR3 (Kabat)

<400>  101

Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
1               5                   10          


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 and huVHH-077 CDR1 (IMGT)

<400>  102

Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr 
1               5                   10  


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 and huVHH-077 CDR2 (IMGT)

<400>  103

Ile Ala Ala Ser Gly Ser Thr 
1               5           


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 and huVHH-077 CDR3 (IMGT)

<400>  104

Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
1               5                   10                  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR1 (Kabat)

<400>  105

Val Tyr Thr Trp Gly Thr Tyr Cys Met Gly 
1               5                   10  


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR2 (Kabat)

<400>  106

Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR3 (Kabat)

<400>  107

Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp Thr Gly Ala Val Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR1 (IMGT)

<400>  108

Val Tyr Thr Trp Gly Thr Tyr Cys 
1               5               


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR2 (IMGT)

<400>  109

Ile Asp Pro Ala Gly Thr Thr 
1               5           


<210>  110
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR3 (IMGT)

<400>  110

Ala Ala Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp Thr Gly Ala Val 
1               5                   10                  15      


Phe Arg Asp 
            


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR1 (Kabat)

<400>  111

Gly Ser Met Tyr Ser Arg Tyr Cys Met Gly 
1               5                   10  


<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR2 (Kabat)

<400>  112

Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR3 (Kabat)

<400>  113

Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp Thr Gly Ala Val Phe Gly 
1               5                   10                  15      


Asp 
    


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR1 (IMGT)

<400>  114

Gly Ser Met Tyr Ser Arg Tyr Cys 
1               5               


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR2 (IMGT)

<400>  115

Ile Asp Pro Ala Gly Thr Thr 
1               5           


<210>  116
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR3 (IMGT)

<400>  116

Ala Ala Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp Thr Gly Ala Val 
1               5                   10                  15      


Phe Gly Asp 
            


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR1 (Kabat)

<400>  117

Gly Tyr Thr Tyr Arg Gly Tyr Cys Leu Ala 
1               5                   10  


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR2 (Kabat)

<400>  118

Thr Ile Asp Ser Asp Gly Tyr Ile Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  119
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR3 (Kabat)

<400>  119

Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys Glu Tyr Asn Tyr 
1               5                   10                  


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR1 (IMGT)

<400>  120

Gly Tyr Thr Tyr Arg Gly Tyr Cys 
1               5               


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR2 (IMGT)

<400>  121

Ile Asp Ser Asp Gly Tyr Ile 
1               5           


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR3 (IMGT)

<400>  122

Ala Ala Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR1 (Kabat)

<400>  123

Leu Ser Leu Asn Arg Val Ser Ile Ala 
1               5                   


<210>  124
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR2 (Kabat)

<400>  124

Thr Gln Ser Phe Thr Gly Asp Thr Ala Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  125
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR3 (Kabat)

<400>  125

Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala Asp Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR1 (IMGT)

<400>  126

Leu Ser Leu Asn Arg Val Ser 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR2 (IMGT)

<400>  127

Gln Ser Phe Thr Gly Asp Thr 
1               5           


<210>  128
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR3 (IMGT)

<400>  128

Ala Ala Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala Asp Glu Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  129
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 (amino acid)

<400>  129

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Glu Ile Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Lys Tyr Ser Gly Gly Ser Phe Arg Ser Val 
            20                  25                  30          


Ser Met Gly Trp Leu Arg Gln Ala Val Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Leu Leu Thr Ala Gly Met Arg Ser Asp Val Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Ile Asp Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Asp Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Arg Phe Arg Ser Asp His Trp Tyr Leu Asp Asp Tyr 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  130
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 (amino acid)

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  131
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 (amino acid)

<400>  131

Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Val Tyr Thr Trp Gly Thr Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Asp Asp Asn Ala Gln Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Ala Tyr Asp Ala Pro Trp Ala Cys Trp Thr Gly Ala Val Phe 
            100                 105                 110         


Arg Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  132
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 (amino acid)

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Met Tyr Ser Arg Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Asp Pro Ala Gly Thr Thr Thr Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Gln Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Ala Tyr Asp Ala Pro Trp Ser Cys Trp Thr Gly Ala Val Phe 
            100                 105                 110         


Gly Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  133
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 (amino acid)

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Arg Gly Tyr 
            20                  25                  30          


Cys Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Thr Ile Asp Ser Asp Gly Tyr Ile Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Thr Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Gly Gly Trp Cys Tyr Ser Leu Ser Lys Glu Tyr Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  134
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 (amino acid)

<400>  134

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Glu Ser Leu Ser Leu Asn Arg Val Ser 
            20                  25                  30          


Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
        35                  40                  45              


Thr Gln Ser Phe Thr Gly Asp Thr Ala Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val Tyr Leu Ser 
65                  70                  75                  80  


Met Asn Ser Leu Lys Leu Glu Asp Ser Ala Lys Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Gly Arg Thr Tyr Ser Ser Arg Asp Pro Leu Ala Asp Glu Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  135
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huVHH-077 (amino acid)

<400>  135

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  136
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-18 (nucleic acid)

<400>  136
caggttaagc tggtggagag cggaggcggc tccgtggaga tcggtggctc cctacgcctg       60

gcctgcaagt actccggtgg ttccttccgc tcggtatcta tgggctggct ccgccaggcc      120

gtggggaagg agcgcgaggg cgtcgctctg cttactgctg gaatgcgtag cgacgtgtac      180

gcggacccgg tgaagggccg cttcaccatc tcacaggata ttgacaaaaa cacgatgtac      240

ctggacatga acgcgctgaa gcccgaagac accgccatgt attactgtgc cgcagggcga      300

aggtttcgga gtgaccactg gtacttggat gactacgagt attggggcca gggcacccag      360

gtcaccgtga gctct                                                       375


<210>  137
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-66 (nucleic acid)

<400>  137
gaggtgcagc tggtggagag tgggcccggg ttggtgaagc cctctcagac tctgtctctg       60

acctgcaccg tgtccggtgc ttccatcacc accggcgagt tctattggaa ttggttccgc      120

cagccgcctg gcaagggcct ggagtggatg ggcgccatcg cggcttctgg ctccacgacc      180

tactccccat ccttcgagag ccgcaccagc atctctcgcg acacctccga gaaccagttc      240

tacctgcagc tgagctccgt gactccggaa gataccgccg tgtactactg cgggcgcagc      300

ttcggcgtgg cggccgtcac cacaggccag aaccgcggac agggcaccca ggtcaccgtg      360

tcgtcc                                                                 366


<210>  138
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-87 (nucleic acid)

<400>  138
caaatccagc tggtggagag tggtggtgga tcggtgcaga gcggaggctc cctccgcctg       60

tcatgcaagg cctccgtgta cacctggggc acctactgta tgggctggtt ccgccaggcc      120

cccgggaagg agcgcgaggg cgtcgcaact attgacccag ctgggaccac aacttacgcc      180

aactccgtta agggccgctt caccatcagc gatgacaacg cgcagaacac gctgtacctg      240

cagatgaact ccttgaggcc tgaagacacc gccatgtatt actgtgctgc gcgggcctac      300

gacgctccgt gggcgtgctg gacgggtgcc gtgtttcgtg attggggcca gggcacccag      360

gtcaccgtgt cctct                                                       375


<210>  139
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-90 (nucleic acid)

<400>  139
caagtgcagc tggtggagag cggaggcggc tccgtgcaga gcggtggcag tctcaagctg       60

agctgcgccg cttccggttc tatgtactcc cgctactgca tgggctggtt ccgccaggcc      120

cccgggaagg agagggaggg cgtcgcaact attgaccctg ctggaacaac cacctacgcg      180

aactccgtta aaggccgctt caccatctct ggggacaacg cgcagaacac gatgtacctg      240

cagatgaact ccttgcggcc cgaagacacc gccatgtatt actgtgctgc tcgtgcctac      300

gacgccccgt ggtcttgttg gactggggcg gtgtttggtg attggggcca gggcacccag      360

gtcaccgtgt cgtcg                                                       375


<210>  140
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-102 (nucleic acid)

<400>  140
gaggtgcagc tggtggagag cggaggtggg tctgtgcaaa gcggcggctc cctccgcctg       60

tcatgcgccg cttccggata cacctacagg ggctactgcc tggcgtggtt ccgccaggcc      120

cccgggaaag agcgcgagcg ggtcgccact attgacagcg atggctacat ctcgtacgcg      180

gactccgtga agggccgctt taccatctct caggacaaca ctaagaacac gttgtacctg      240

gagatgaata cactgaagcc tgaagacacc gccatgtatt actgtgctgc acgtggtggt      300

tggtgttact ccctttccaa ggagtacaac tattggggcc agggcaccca ggtcaccgtt      360

tcgagt                                                                 366


<210>  141
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-105 (nucleic acid)

<400>  141
caagtgcagc tggtggagag cggaggcggc tccgtgcagg ccggtggttc tcttcgattg       60

tcatgcgccg aaagtctatc tctcaaccgc gtcagcattg catggttccg ccaggctcct      120

ggcaaggaga gggagggcgt agctacccag agctttacag gggacaccgc gtacgcggat      180

tctgttaaag ggcgcttcac catctcccgc gacaacacta agaacacggt gtacctgtcc      240

atgaactccc tgaagctgga ggacagcgcc aagtactact gtgccgctgg acgtacttac      300

tcctcccggg atcccctggc ggacgagtac aactattggg gccagggcac ccaggtcacc      360

gtgtcgtcg                                                              369


<210>  142
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huVHH-077 (nucleic acid)

<400>  142
caggtgcagc tgcaggagag tgggcccggg ttggtgaagc cctctcagac tctttctctg       60

acctgcaccg tgtccggtgc ttccatcacc accggcgagt tctattggaa ttggttccgc      120

cagccgcccg gcaagggcct ggagtggatg ggcgccatcg cggcttctgg ctccacgacc      180

tactccccat ccttcgagag ccgcaccagc atctcccgcg acacctccaa gaaccagttt      240

tcactgaagc tgagctccgt gacggccgcg gacaccgccg tgtactactg cgggcgctcc      300

ttcggcgtgg cggccgtcac cacaggccag aaccgcggac agggcaccct ggtgaccgtg      360

agctcg                                                                 366


<210>  143
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 1


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  143

Gly Ser 
1       


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 2


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  144

Gly Ser Gly Gly Ser 
1               5   


<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 3


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  145

Gly Gly Gly Ser 
1               


<210>  146
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 4

<400>  146

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser 
        


<210>  147
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 5


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  can be repeated n times, where n is an integer including, e.g., 
       1, 2, 3, 4, 5, and 6

<400>  147

Gly Gly Gly Gly Ser 
1               5   


<210>  148
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 6

<400>  148

Asp Gly Gly Gly Ser 
1               5   


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 7

<400>  149

Thr Gly Glu Lys Pro 
1               5   


<210>  150
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 8

<400>  150

Gly Gly Arg Arg 
1               


<210>  151
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 9

<400>  151

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  152
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 10

<400>  152

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  153
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 11

<400>  153

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 12

<400>  154

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 13

<400>  155

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  156
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 14

<400>  156

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  157
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 15

<400>  157

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  158
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 16

<400>  158

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


<210>  159
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 17

<400>  159

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  160
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary peptide linker 18

<400>  160

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  161
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Peptide (CD8Alpha)

<400>  161

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  162
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge (CD8Alpha)

<400>  162

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  163
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transmembrane domain (CD8Alpha)

<400>  163

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  164
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-stimulatory signaling domain (CD137)

<400>  164

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  165
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primary intracellular signaling domain (CD3Zeta)

<400>  165

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  166
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  166
gccgccacc                                                                9


<210>  167
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EcoRI restriction site

<400>  167
gaattc                                                                   6


<210>  168
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SpeI restriction site

<400>  168
actagt                                                                   6


<210>  169
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG1 Fc fragment sequence

<400>  169

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  170
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab VH-CH1

<400>  170

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  171
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab VL-CL

<400>  171

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  172
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leu16 VH-CH1

<400>  172

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys 
225 


<210>  173
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leu16 VL-CL

<400>  173

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  174
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-2C1 CAR (amino acid)

<400>  174

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    130                 135                 140                 


Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu 
145                 150                 155                 160 


Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp 
                165                 170                 175     


Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala 
            180                 185                 190         


Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg 
        195                 200                 205             


Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu 
    210                 215                 220                 


Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser 
225                 230                 235                 240 


Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln 
305                 310                 315                 320 


Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr 
            340                 345                 350         


Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly 
        355                 360                 365             


Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  175
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-2C2 CAR (amino acid)

<400>  175

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
145                 150                 155                 160 


Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr 
                165                 170                 175     


Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu 
            180                 185                 190         


Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro 
        195                 200                 205             


Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln 
    210                 215                 220                 


Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
                245                 250                 255     


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
        275                 280                 285             


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
    290                 295                 300                 


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
                325                 330                 335     


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
        355                 360                 365             


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
    370                 375                 380                 


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                405                 410                 415     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            420                 425                 430         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        435                 440                 445             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    450                 455                 460                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
465                 470                 475                 480 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                485                 490                 495     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  176
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-2C3 CAR (amino acid)

<400>  176

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
                165                 170                 175     


Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser 
        195                 200                 205             


Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp 
    210                 215                 220                 


Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val 
                245                 250                 255     


Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys 
305                 310                 315                 320 


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                325                 330                 335     


Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
    370                 375                 380                 


Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg 
385                 390                 395                 400 


Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr 
                405                 410                 415     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            420                 425                 430         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        435                 440                 445             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    450                 455                 460                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
465                 470                 475                 480 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                485                 490                 495     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            500                 505                 510         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210>  177
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-2C4 CAR (amino acid)

<400>  177

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr 
                165                 170                 175     


Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn 
            180                 185                 190         


Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile 
        195                 200                 205             


Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr 
    210                 215                 220                 


Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser 
225                 230                 235                 240 


Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe 
                245                 250                 255     


Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly 
305                 310                 315                 320 


Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr 
            340                 345                 350         


Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys 
    370                 375                 380                 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu 
385                 390                 395                 400 


Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr 
                405                 410                 415     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                485                 490                 495     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            500                 505                 510         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        515                 520                 525             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  178
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-3C1 CAR (amino acid)

<400>  178

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  179
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-3C2 CAR (amino acid)

<400>  179

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly 
                165                 170                 175     


Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr 
        195                 200                 205             


Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys 
225                 230                 235                 240 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu 
                245                 250                 255     


Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    290                 295                 300                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
305                 310                 315                 320 


Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
                325                 330                 335     


Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
        355                 360                 365             


Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                405                 410                 415     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            420                 425                 430         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        435                 440                 445             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    450                 455                 460                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
465                 470                 475                 480 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                485                 490                 495     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  180
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-3C3 CAR (amino acid)

<400>  180

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala 
        195                 200                 205             


Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
                245                 250                 255     


Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn 
            260                 265                 270         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly 
            340                 345                 350         


Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        355                 360                 365             


Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu 
    370                 375                 380                 


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr 
385                 390                 395                 400 


Leu Thr Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr 
                405                 410                 415     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            420                 425                 430         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        435                 440                 445             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    450                 455                 460                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
465                 470                 475                 480 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                485                 490                 495     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            500                 505                 510         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210>  181
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-3C4 CAR (amino acid)

<400>  181

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln 
                165                 170                 175     


Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn 
            180                 185                 190         


Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser 
            260                 265                 270         


Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr 
                405                 410                 415     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                485                 490                 495     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            500                 505                 510         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        515                 520                 525             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  182
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-4C1 CAR (amino acid)

<400>  182

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                165                 170                 175     


Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
            260                 265                 270         


Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
        275                 280                 285             


Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln 
305                 310                 315                 320 


Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr 
            340                 345                 350         


Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly 
        355                 360                 365             


Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  183
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-4C2 CAR (amino acid)

<400>  183

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly 
        195                 200                 205             


Asp Arg Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys 
225                 230                 235                 240 


Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu 
                245                 250                 255     


Thr Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
        275                 280                 285             


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
    290                 295                 300                 


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
                325                 330                 335     


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
        355                 360                 365             


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
    370                 375                 380                 


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                405                 410                 415     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            420                 425                 430         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        435                 440                 445             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    450                 455                 460                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
465                 470                 475                 480 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                485                 490                 495     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  184
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-4C3 CAR (amino acid)

<400>  184

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Pro Met 
            180                 185                 190         


Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val Ser Asp 
        195                 200                 205             


Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Glu 
225                 230                 235                 240 


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
                245                 250                 255     


Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    290                 295                 300                 


Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys 
305                 310                 315                 320 


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
                325                 330                 335     


Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
    370                 375                 380                 


Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg 
385                 390                 395                 400 


Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr 
                405                 410                 415     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            420                 425                 430         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        435                 440                 445             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    450                 455                 460                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
465                 470                 475                 480 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                485                 490                 495     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            500                 505                 510         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210>  185
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-4C4 CAR (amino acid)

<400>  185

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            180                 185                 190         


Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly 
305                 310                 315                 320 


Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr 
            340                 345                 350         


Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys 
    370                 375                 380                 


Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu 
385                 390                 395                 400 


Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr 
                405                 410                 415     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                485                 490                 495     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            500                 505                 510         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        515                 520                 525             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  186
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-5C1 CAR (amino acid)

<400>  186

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly 
            180                 185                 190         


Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn 
    210                 215                 220                 


Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro 
225                 230                 235                 240 


Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly 
                245                 250                 255     


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
        275                 280                 285             


Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe 
    290                 295                 300                 


Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu 
                325                 330                 335     


Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu 
            340                 345                 350         


Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
        355                 360                 365             


Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  187
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-5C2 CAR (amino acid)

<400>  187

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg 
                165                 170                 175     


Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
            180                 185                 190         


Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu 
    210                 215                 220                 


Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp 
                245                 250                 255     


Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
    290                 295                 300                 


Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg 
305                 310                 315                 320 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser 
                325                 330                 335     


Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser 
            340                 345                 350         


Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr 
        355                 360                 365             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala 
    370                 375                 380                 


Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                405                 410                 415     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            420                 425                 430         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        435                 440                 445             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    450                 455                 460                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
465                 470                 475                 480 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                485                 490                 495     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  188
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-5C3 CAR (amino acid)

<400>  188

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly 
                165                 170                 175     


Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser 
        195                 200                 205             


Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala 
                245                 250                 255     


Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro 
    290                 295                 300                 


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr 
305                 310                 315                 320 


Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly 
                325                 330                 335     


Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser 
            340                 345                 350         


Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn 
        355                 360                 365             


Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln 
385                 390                 395                 400 


Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr 
                405                 410                 415     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            420                 425                 430         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        435                 440                 445             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    450                 455                 460                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
465                 470                 475                 480 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                485                 490                 495     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            500                 505                 510         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210>  189
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-5C4 CAR (amino acid)

<400>  189

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly 
        115                 120                 125             


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln 
        195                 200                 205             


Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly 
                245                 250                 255     


Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln 
            260                 265                 270         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    290                 295                 300                 


Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu 
305                 310                 315                 320 


Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp 
                325                 330                 335     


Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala 
            340                 345                 350         


Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg 
        355                 360                 365             


Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu 
    370                 375                 380                 


Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser 
385                 390                 395                 400 


Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr 
                405                 410                 415     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                485                 490                 495     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            500                 505                 510         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        515                 520                 525             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  190
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-6C1 CAR (amino acid)

<400>  190

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser 
        115                 120                 125             


Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln 
145                 150                 155                 160 


Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn 
                165                 170                 175     


Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            180                 185                 190         


Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val 
        195                 200                 205             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn 
    210                 215                 220                 


Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met 
225                 230                 235                 240 


Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser 
                245                 250                 255     


Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
        275                 280                 285             


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
    290                 295                 300                 


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
                325                 330                 335     


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
            340                 345                 350         


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
    370                 375                 380                 


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  191
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-6C2 CAR (amino acid)

<400>  191

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser 
        115                 120                 125             


Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala 
                165                 170                 175     


Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly 
        195                 200                 205             


Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu 
                245                 250                 255     


Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        275                 280                 285             


Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
    290                 295                 300                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu 
305                 310                 315                 320 


Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
                325                 330                 335     


Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe 
            340                 345                 350         


Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr 
        355                 360                 365             


Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly 
385                 390                 395                 400 


Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala 
                405                 410                 415     


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
            420                 425                 430         


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        435                 440                 445             


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    450                 455                 460                 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
465                 470                 475                 480 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                485                 490                 495     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            500                 505                 510         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        515                 520                 525             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    530                 535                 540                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
545                 550                 555                 560 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                565                 570                 575     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            580                 585                 590         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        595                 600                 605             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    610                 615                 620                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 


<210>  192
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-6C3 CAR (amino acid)

<400>  192

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser 
        115                 120                 125             


Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn Cys Met Gly 
            180                 185                 190         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala Ile 
        195                 200                 205             


Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala Ala 
                245                 250                 255     


Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr Arg Asn Trp 
            260                 265                 270         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr 
305                 310                 315                 320 


Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe 
                325                 330                 335     


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala 
            340                 345                 350         


Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile 
        355                 360                 365             


Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val 
    370                 375                 380                 


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val 
385                 390                 395                 400 


Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr 
                405                 410                 415     


Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            420                 425                 430         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        435                 440                 445             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    450                 455                 460                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                485                 490                 495     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            500                 505                 510         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        515                 520                 525             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    530                 535                 540                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
545                 550                 555                 560 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                565                 570                 575     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            580                 585                 590         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        595                 600                 605             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    610                 615                 620                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
625                 630                 635                 640 


Leu Pro Pro Arg 
                


<210>  193
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-6C4 CAR (amino acid)

<400>  193

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser 
        115                 120                 125             


Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
                165                 170                 175     


Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser 
            180                 185                 190         


Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        195                 200                 205             


Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala 
            260                 265                 270         


Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys 
305                 310                 315                 320 


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile 
                325                 330                 335     


Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys 
            340                 345                 350         


Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr 
        355                 360                 365             


Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu 
    370                 375                 380                 


Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly 
                405                 410                 415     


Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr 
            420                 425                 430         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        435                 440                 445             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    450                 455                 460                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
465                 470                 475                 480 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                485                 490                 495     


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            500                 505                 510         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        515                 520                 525             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    530                 535                 540                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
545                 550                 555                 560 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                565                 570                 575     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            580                 585                 590         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        595                 600                 605             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    610                 615                 620                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
625                 630                 635                 640 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650                 


<210>  194
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-7C1 CAR (amino acid)

<400>  194

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg 
        195                 200                 205             


Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly 
                245                 250                 255     


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
        275                 280                 285             


Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe 
    290                 295                 300                 


Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
305                 310                 315                 320 


Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu 
                325                 330                 335     


Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu 
            340                 345                 350         


Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
        355                 360                 365             


Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  195
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-7C2 CAR (amino acid)

<400>  195

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                165                 170                 175     


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp 
            180                 185                 190         


Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val Ser Asp Ile Thr 
        195                 200                 205             


Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Glu Met Asn 
225                 230                 235                 240 


Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp 
                245                 250                 255     


Arg Thr Leu Thr Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        275                 280                 285             


Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val 
    290                 295                 300                 


Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg 
305                 310                 315                 320 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser 
                325                 330                 335     


Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser 
            340                 345                 350         


Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr 
        355                 360                 365             


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala 
    370                 375                 380                 


Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                405                 410                 415     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            420                 425                 430         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        435                 440                 445             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    450                 455                 460                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
465                 470                 475                 480 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                485                 490                 495     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  196
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-7C3 CAR (amino acid)

<400>  196

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
            180                 185                 190         


Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser 
        195                 200                 205             


Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu 
225                 230                 235                 240 


Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Gln Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro 
    290                 295                 300                 


Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr 
305                 310                 315                 320 


Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly 
                325                 330                 335     


Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser 
            340                 345                 350         


Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn 
        355                 360                 365             


Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln 
385                 390                 395                 400 


Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr 
                405                 410                 415     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            420                 425                 430         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        435                 440                 445             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    450                 455                 460                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
465                 470                 475                 480 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                485                 490                 495     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            500                 505                 510         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210>  197
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-7C4 CAR (amino acid)

<400>  197

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
                165                 170                 175     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            180                 185                 190         


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
225                 230                 235                 240 


Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp 
                245                 250                 255     


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
            260                 265                 270         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    290                 295                 300                 


Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu 
305                 310                 315                 320 


Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp 
                325                 330                 335     


Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala 
            340                 345                 350         


Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg 
        355                 360                 365             


Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu 
    370                 375                 380                 


Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser 
385                 390                 395                 400 


Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr 
                405                 410                 415     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                485                 490                 495     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            500                 505                 510         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        515                 520                 525             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  198
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-8C1 CAR (amino acid)

<400>  198

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  199
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-8C2 CAR (amino acid)

<400>  199

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
145                 150                 155                 160 


Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu 
                165                 170                 175     


Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp 
            180                 185                 190         


Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala 
        195                 200                 205             


Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg 
    210                 215                 220                 


Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu 
225                 230                 235                 240 


Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser 
                245                 250                 255     


Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr 
            260                 265                 270         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    290                 295                 300                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
305                 310                 315                 320 


Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Val 
                325                 330                 335     


Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
        355                 360                 365             


Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                405                 410                 415     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            420                 425                 430         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        435                 440                 445             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    450                 455                 460                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
465                 470                 475                 480 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                485                 490                 495     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            500                 505                 510         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        515                 520                 525             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    530                 535                 540                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
545                 550                 555                 560 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                565                 570                 575     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            580                 585                 590         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        595                 600                 605             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    610                 615                 620                 


Pro Pro Arg 
625         


<210>  200
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-8C3 CAR (amino acid)

<400>  200

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
                165                 170                 175     


Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Thr Thr 
            180                 185                 190         


Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr Ser Pro 
    210                 215                 220                 


Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu Asn Gln 
225                 230                 235                 240 


Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr 
                245                 250                 255     


Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly Gln Asn 
            260                 265                 270         


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly 
            340                 345                 350         


Gly Asp Arg Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        355                 360                 365             


Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Glu Met Asn Ser Leu 
    370                 375                 380                 


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr 
385                 390                 395                 400 


Leu Thr Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr Ser Thr Thr 
                405                 410                 415     


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
            420                 425                 430         


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
        435                 440                 445             


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
    450                 455                 460                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
465                 470                 475                 480 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                485                 490                 495     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            500                 505                 510         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        515                 520                 525             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    530                 535                 540                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
545                 550                 555                 560 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                565                 570                 575     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            580                 585                 590         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        595                 600                 605             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    610                 615                 620                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635         


<210>  201
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-8C4 CAR (amino acid)

<400>  201

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
            180                 185                 190         


Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro 
        195                 200                 205             


Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser 
    210                 215                 220                 


Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp 
225                 230                 235                 240 


Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val 
            260                 265                 270         


Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Asn Met Leu Tyr Leu Glu Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln Gly Thr 
                405                 410                 415     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            420                 425                 430         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        435                 440                 445             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    450                 455                 460                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
465                 470                 475                 480 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                485                 490                 495     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            500                 505                 510         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        515                 520                 525             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    530                 535                 540                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
545                 550                 555                 560 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                565                 570                 575     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            580                 585                 590         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        595                 600                 605             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    610                 615                 620                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
625                 630                 635                 640 


Met Gln Ala Leu Pro Pro Arg 
                645         


<210>  202
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-9C1 CAR (amino acid)

<400>  202

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser 
        115                 120                 125             


Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys 
145                 150                 155                 160 


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile 
                165                 170                 175     


Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr Thr Tyr 
        195                 200                 205             


Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Glu 
    210                 215                 220                 


Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr Thr Gly 
                245                 250                 255     


Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
        275                 280                 285             


Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser 
    290                 295                 300                 


Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
305                 310                 315                 320 


Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr 
        355                 360                 365             


Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala 
    370                 375                 380                 


Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  203
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-10C1 CAR (amino acid)

<400>  203

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Gly Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  204
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-11C1 CAR (amino acid)

<400>  204

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                165                 170                 175     


Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            180                 185                 190         


Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro Tyr Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys 
    210                 215                 220                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp Ser Gly 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
        275                 280                 285             


Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser 
    290                 295                 300                 


Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
305                 310                 315                 320 


Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Val Asp 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Thr 
            340                 345                 350         


Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr 
        355                 360                 365             


Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala 
    370                 375                 380                 


Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  205
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-12C1 CAR (amino acid)

<400>  205

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser 
        195                 200                 205             


Pro Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Gly Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser 
                245                 250                 255     


Trp Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu 
        275                 280                 285             


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
    290                 295                 300                 


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
305                 310                 315                 320 


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
                325                 330                 335     


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
            340                 345                 350         


Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
    370                 375                 380                 


Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  206
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIO-13C1 CAR

<400>  206

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Glu Asn Gln Phe Tyr Leu Gln Leu Ser Ser Val Thr Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Glu Arg Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Gly Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  207
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-100 CAR (amino acid)

<400>  207

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Leu Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Ile Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Trp Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  208
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-133 CAR (amino acid)

<400>  208

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  209
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-167 CAR (amino acid)

<400>  209

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  210
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-180 CAR (amino acid)

<400>  210

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Val Ala Ala Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  211
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-203 CAR (amino acid)

<400>  211

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  212
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-213 CAR (amino acid)

<400>  212

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Val Ala Ala Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  213
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-217 CAR (amino acid)

<400>  213

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  214
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-227 CAR (amino acid)

<400>  214

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Val Ala Ala Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  215
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-230 CAR (amino acid)

<400>  215

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  216
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-240 CAR (amino acid)

<400>  216

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Trp Val Ala Ala Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  217
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-243 CAR (amino acid)

<400>  217

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Phe Val Ala Val Val Asp Trp Ser Gly Gly Ser Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ser Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Gly Arg Val Gln Tyr Gly Ser Ser Trp 
    370                 375                 380                 


Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr 
385                 390                 395                 400 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                405                 410                 415     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            420                 425                 430         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        435                 440                 445             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    450                 455                 460                 


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
465                 470                 475                 480 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
                485                 490                 495     


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            500                 505                 510         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        515                 520                 525             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    530                 535                 540                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
545                 550                 555                 560 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                565                 570                 575     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            580                 585                 590         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        595                 600                 605             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620                 


<210>  218
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-267 CAR (amino acid)

<400>  218

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Leu Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Ile Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Trp Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  219
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-300 CAR (amino acid)

<400>  219

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  220
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-333 CAR (amino acid)

<400>  220

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn 
        35                  40                  45              


Ile Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr 
65                  70                  75                  80  


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu 
        115                 120                 125             


Arg Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Ala Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln 
            180                 185                 190         


Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly 
        195                 200                 205             


Ser Thr Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg 
    210                 215                 220                 


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
225                 230                 235                 240 


Ala Asp Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala 
                245                 250                 255     


Val Thr Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  221
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-433 CAR (amino acid)

<400>  221

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Leu Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Ile Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Trp Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  222
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-467 CAR (amino acid)

<400>  222

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  223
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-500 CAR (amino acid)

<400>  223

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  224
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-600 CAR (amino acid)

<400>  224

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Leu Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Ile Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Trp Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  225
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-633 CAR (amino acid)

<400>  225

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  226
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huAIO-667 CAR (amino acid)

<400>  226

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala 
        35                  40                  45              


Ser Ile Thr Thr Gly Glu Phe Tyr Trp Asn Trp Phe Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Met Gly Ala Ile Ala Ala Ser Gly Ser Thr 
65                  70                  75                  80  


Thr Tyr Ser Pro Ser Phe Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Gly Arg Ser Phe Gly Val Ala Ala Val Thr 
        115                 120                 125             


Thr Gly Gln Asn Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile 
                165                 170                 175     


Asn Ser Arg Asn Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Arg Glu Gly Val Ala Ala Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr 
        195                 200                 205             


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg 
                245                 250                 255     


Ser Ala Asp Tyr Arg Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Phe Thr Phe Ser Asn Tyr Pro Met Thr Trp Leu Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gly Leu Glu Ser Val Ser Asp Ile Thr Ser Gly Gly Asp Arg Pro 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Thr Trp Asp Arg Thr Leu Thr Gly Gln 
    370                 375                 380                 


Gly Thr Leu Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                405                 410                 415     


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
            420                 425                 430         


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        435                 440                 445             


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
    450                 455                 460                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
465                 470                 475                 480 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                485                 490                 495     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            500                 505                 510         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        515                 520                 525             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    530                 535                 540                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
545                 550                 555                 560 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                565                 570                 575     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            580                 585                 590         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        595                 600                 605             


Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615         


<210>  227
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-2C1 CAR (nucleic acid)

<400>  227
atggcgcttc cggtgacggc actgctgctg cccctggctt tgctactaca cgccgcccgc       60

cctcagatcc agctggtgga gagcggcggc ggactggtgc agccgggagg ctcgctgcgt      120

ctttcctgtg ccgcttccgg cttcaccttt tcaaattacc caatgacctg gctgcgacag      180

gcccccggga agggcctcga gagcgtttcc gacatcactt ctggagggga caggccctat      240

tacgcggaca gcgtcaaggg aaggtttacc atctcgcgcg acaacgcgaa gaacatgctg      300

tacctggaga tgaatagtct gaagaccgaa gatactgcgg tgtactactg tgctacctgg      360

gaccgcaccc tgactggaca gggcacccag gtcacagtct cctctggcgg cggcgggtcg      420

gaggtgcaat tagtggagtc cggccctggt ctcgtgaagc cctcacagac tctgagcctg      480

acctgcactg tatcgggtgc ttctatcacc acaggcgagt tctattggaa ttggttcaga      540

cagccacctg gcaaaggtct ggagtggatg ggcgccatcg cagctagcgg ctccaccacc      600

tactccccct cttttgagag ccgtaccagc atctctcggg acacctccga gaaccagttc      660

tacctgcagc tgtcctcggt cactcccgag gacacagccg tgtactattg tgggcgctcc      720

ttcggcgtgg cagctgtgac cacaggacag aaccgcggcc agggcaccca ggtcaccgtg      780

tcgtccggtg gtggtggctc ccaggttcaa ttggtggaga gtggtggcgg ctctgtgcag      840

gccggcggtt ctctgcgcct gtcatgcggg gcctcgggca acattaactc ccgcaactgc      900

atggggtggt tccgccaggc cccgggcaag gagcgcgagg gcgtcgctgc tatcggtcag      960

gtcaccggtc gcagctacta cgtggattct gttaaaggcc gcttcacgat ttctctcgat     1020

aacgccaaga acacgctcta cttgcagatg aacacgctca agcctgaaga caccgcgatg     1080

tattactgtg ccgcagcgcc ggggtgcctg ctgtccgccc tgcgtagtgc cgactaccgg     1140

aactggggcc aggggaccca ggtgaccgtg tcctccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  228
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-2C2 CAR (nucleic acid)

<400>  228
atggcccttc cggtgactgc tctgctgctg cccctggcgc tgctgctcca cgccgctcgc       60

cctcagatcc agctggtgga gagcggaggc ggcttggtgc agccgggcgg ctccctgcgc      120

ctgtcatgcg ccgcttccgg cttcaccttt tcaaactacc cgatgacctg gctacgacag      180

gcccccggca aaggcctgga gagcgtgtct gacatcactt cgggggggga caggccctat      240

tacgcggaca gcgtcaaagg tcgcttcacc atctctcgcg acaacgccaa gaacatgctg      300

tacctcgaga tgaactccct gaagaccgag gacacggcag tctactactg tgccacctgg      360

gaccgcaccc tgaccggaca gggcacgcag gtcactgtct cctccggtgg cggaggatct      420

ggtggtggtg gctccgaggt gcaactggtg gagagtgggc cgggcttagt taagcccagt      480

cagactctga gcctcacctg taccgtgtcc ggtgcgagca tcaccaccgg cgagttctat      540

tggaactggt tccgccagcc acccggtaag ggcctggaat ggatgggcgc cattgcagcg      600

tctgggtcta ctacctactc cccatccttc gagagccgta caagtatctc gcgggacacc      660

tccgagaacc agttctactt gcagctttct tctgtgacac ctgaggacac cgccgtgtac      720

tactgtgggc gcagttttgg cgttgctgcc gttacgaccg gtcagaaccg cggacagggt      780

acccaggtaa ccgtctcctc cggcggtggg ggctccggag gcggaggctc ccaggtgcaa      840

ctggtggagt ctggtggagg gtcggtgcag gccggcggca gcttgcgttt gtcatgcggg      900

gcctcgggca acattaactc ccgcaactgc atggggtggt tcagacaggc tcctggcaag      960

gagcgcgagg gcgtggcggc catcggccag gtcaccggcc gctcgtacta cgtggattct     1020

gtgaagggtc gttttaccat cagcctggat aacgctaaga atactcttta cctgcagatg     1080

aacacactca agcctgaaga tacggctatg tattactgtg ctgctgcgcc cgggtgcctg     1140

ctcagcgcac ttaggagcgc ggactaccgg aattggggcc agggcaccca ggtcaccgtg     1200

tcgtccacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1260

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1320

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1380

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1440

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1500

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1560

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1620

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1680

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1740

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1800

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1860

atgcaggccc tgccccctcg ctaa                                            1884


<210>  229
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-2C3 CAR (nucleic acid)

<400>  229
atggctctgc ccgtgacggc cttgctgctg ccacttgcac tgctgctgca cgccgcacgg       60

cctcagatcc agctggtaga gtctggaggg ggtctggtgc agccgggagg ctccctgcgt      120

ttgtcttgtg ccgcatcggg cttcacgttc agcaactacc ctatgacctg gctgcgtcag      180

gctccgggca aaggccttga gagcgtttcc gacatcacgt cgggggggga ccgcccctat      240

tacgcggaca gcgtgaaggg ccgtttcacc atctcccggg acaacgccaa gaatatgctg      300

tacctggaga tgaactccct caagaccgag gacaccgccg tctactactg tgctacctgg      360

gatcgaactc tgaccggcca gggcacccag gtcaccgtct cttctggtgg cggcggcagt      420

ggcggcggtg gttccggagg cggcggcagc gaggtgcagt tggtggagtc tggccctggc      480

ctggttaagc ccagtcagac tctttccctc acctgcaccg tgtccggcgc ctcaattacc      540

acaggcgagt tctattggaa ttggttccgc cagcccccag gaaaggggct ggagtggatg      600

ggcgccatcg cggcctccgg ctctacgacc tactccccct cttttgagag ccggaccagc      660

atctctcgcg acacctcgga gaaccagttt tatctccagc tctcctctgt aactccggaa      720

gatacagccg tgtactactg cgggaggtcc ttcggtgtgg cggcggtgac tacaggacag      780

aaccgcggtc agggcaccca ggtcactgtc tcctcgggtg ggggcggctc cggtggaggc      840

ggtagcggag gcgggggcag ccaggtgcag ctggtggaaa gtggtggcgg ctccgtgcaa      900

gccggaggtt cattacgcct gtcctgtggc gcttccggca acattaactc ccgcaactgc      960

atgggctggt tccgccaggc tcccgggaag gagagagagg gcgtggctgc gatcggtcaa     1020

gtgaccggtc gcagctacta cgtggattct gtcaaaggga ggtttaccat ctcgctggac     1080

aacgctaaga acacgcttta cttgcagatg aacactctga agcctgaaga caccgccatg     1140

tattactgtg cggcggcccc ggggtgcctg ctctctgctc tacgctcggc ggactaccgc     1200

aactgggggc agggaaccca ggtcaccgtg agcagcacta gtaccacgac gccagcgccg     1260

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1320

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1380

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1440

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1500

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1560

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1620

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1680

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1740

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1800

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1860

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1914


<210>  230
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-2C4 CAR (nucleic acid)

<400>  230
atggccctgc cggtcacggc tctgctgctg cccctggcgc tgcttttgca cgccgctcgc       60

cctcagatcc agttggtgga gagcggcggc ggcctcgttc agccaggtgg ttccctgcgc      120

ctgagctgtg cggcctctgg ctttacgttc agcaactacc cgatgacctg gctccgtcaa      180

gcccccggaa agggtctgga aagcgtctcc gacatcacct ctggcggtga tcgaccctat      240

tacgcggaca gcgtgaaagg ccgcttcacc atttcccggg acaacgccaa gaacatgctt      300

tacctggaga tgaacagcct gaagaccgag gacacggccg tgtactactg tgccacctgg      360

gacaggacac tcacaggtca gggcacccag gttaccgtgt cgagcggagg cggagggtct      420

ggcggcggcg gctcgggcgg cgggggttcc ggaggcggcg gctcggaggt gcagctagtg      480

gagtcgggac ctggcttggt gaagccatcc cagacccttt cgctgacctg caccgtgtcc      540

ggtgcttcta tcacgaccgg cgagttctat tggaattggt tccgccagcc gcctggtaag      600

ggcttggagt ggatgggcgc catcgcggct tcgggatcga ccacctactc cccctccttc      660

gagtctcgca ccagcatctc tagggacact tccgagaacc agttctacct ccagctgagc      720

tcggtcactc cggaggatac tgccgtgtac tattgtgggc gttcctttgg tgtcgcggcc      780

gtgacaactg gtcagaaccg cggccagggc acccaggtca ccgtgagctc cggcggtggc      840

ggctccggcg gcgggggctc aggtggcgga ggatctgggg ggggtggtag tcaggtgcag      900

ctggtggaga gtgggggggg gtccgtgcag gccggcggtt ctctacggct ttcatgcggg      960

gcttccggca acattaactc ccgcaactgc atggggtggt tcagacaggc tcccggcaag     1020

gagcgcgagg gcgtggcggc aatcggacaa gtaactggtc gcagctacta cgtggactca     1080

gtaaagggcc gttttaccat ctctctggac aatgcaaaaa acacgctgta cctgcagatg     1140

aataccctga agcctgaaga tactgccatg tattactgtg ctgcagcccc cgggtgcctg     1200

ctgtcagctc tgcgctccgc ggactaccgc aactggggcc agggaaccca ggtcaccgtc     1260

agttctacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1320

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1380

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1440

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1500

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1560

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1620

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1680

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1740

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1800

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1860

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1920

atgcaggccc tgccccctcg ctaa                                            1944


<210>  231
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-3C1 CAR (nucleic acid)

<400>  231
atggctctgc cggtgaccgc gctgcttctg cccctggcgc tcctgctaca cgctgcccgg       60

cctgaggtgc agctggtaga gtccggccct ggcctggtca agccaagtca gaccctgtct      120

ctgacctgca ctgtgagcgg tgcgtccatc acaactggcg agttctattg gaattggttc      180

agacagccgc ccggaaaggg cctcgagtgg atgggcgcca tcgccgcttc cggctccacg      240

acctacagcc cctcttttga gagccgcacc agcatcagcc gcgacacatc ggagaaccag      300

ttttacctgc agttgtcctc tgtcactccc gaagacaccg cggtgtacta ctgtggacgc      360

tccttcgggg tagcggccgt aaccacagga cagaaccgcg gccaagggac ccaggtcacg      420

gtgtcgtcgg gcggtggtgg ctcgcaggtg cagctggtgg agtccggagg cggctccgtg      480

caggccggcg ggtccctgcg tctgtcatgc ggggcctctg gcaacattaa ctcccgcaac      540

tgcatgggct ggttccgcca ggcccctggc aaggagcgcg agggcgtggc tgccatcggt      600

caagttactg gccgtagcta ctacgtggat tctgtcaaag ggcgcttcac catctctttg      660

gataacgcca agaacactct ttacttgcag atgaacacgc tcaagcctga agacaccgcc      720

atgtattact gtgccgctgc acccgggtgc ctgctgtccg ctctccgcag cgcggactac      780

aggaactggg gccagggcac ccaggtcacc gtgtcgagcg gcggtggtgg ttcacagatc      840

cagctagtgg agtccggtgg aggactggtg cagccaggcg gcagccttcg cctgtcatgt      900

gctgcgtctg gcttcacgtt ctctaactac ccgatgacct ggctgcgcca ggccccgggc      960

aaaggcctgg agtcggtgtc cgacatcacc tctggagggg acaggcccta ttacgcggac     1020

agcgttaagg gtcggtttac cattagtcgt gacaacgcta agaatatgtt atacctggag     1080

atgaatagcc tgaagaccga ggacactgca gtttattact gtgccacctg ggatcgaact     1140

cttaccggac aggggaccca ggtcaccgtg agttccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  232
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-3C2 CAR (nucleic acid)

<400>  232
atggctctgc cggtgaccgc tctgcttctc cccctggcgt tgctgctgca cgccgcgcgc       60

cctgaggtgc agctggtgga gagcggccct ggcttggtga agccctctca aactctgtcc      120

ctcacctgca ctgtatcagg cgcgtccatc acaaccggcg agttctattg gaattggttc      180

cgccagccgc cggggaaggg ccttgagtgg atgggggcaa tcgccgcgtc tggatcgacc      240

acctactccc cgtccttcga atcccgcacc agcatcagtc gggacacatc ggagaaccag      300

ttttacctcc agttgagctc agtgactccc gaggacactg ccgtgtacta ctgtggtagg      360

tctttcggtg ttgcggccgt gacaactggt cagaaccgcg ggcagggtac ccaggtgact      420

gtctcttctg gtggcggggg ctcgggaggg ggcggttccc aggtccagct ggtggagtcc      480

ggaggcggca gcgtgcaggc cggcggatcc cttcgtctgt cttgcggtgc ttccggcaac      540

attaattccc gcaactgcat gggctggttc agacaggccc ctgggaagga gcgcgagggc      600

gtggctgcca tcggtcaggt caccggtcga tcctactacg tggactccgt aaaaggccgc      660

ttcaccatct cgctggacaa cgccaagaac actctttacc tgcagatgaa cacgctcaag      720

cctgaagata cggccatgta ttactgtgct gcagctcccg gctgcttgct gtctgctctg      780

cgtagtgcgg actaccggaa ctggggccag ggcacccagg tcacagtgtc ctccggggga      840

ggcggctctg ggggcggcgg gagccaaatt cagctggtgg agagcggcgg cggactggtg      900

cagccaggcg gatccctgcg cctgtcatgt gccgcttcgg gcttcacgtt ttctaactac      960

ccaatgacct ggctacgcca ggcccccggc aaaggtttgg agagcgtttc ggacatcacc     1020

tcgggtgggg accgccccta ttacgcggat tctgtcaagg gcaggtttac catcagccgt     1080

gataacgcga agaacatgct gtacctggag atgaatagtc tcaagaccga ggacaccgct     1140

gtctactact gtgccacctg ggaccgcacg ctgaccggac agggcaccca ggtcaccgtg     1200

agctccacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1260

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1320

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1380

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1440

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1500

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1560

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1620

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1680

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1740

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1800

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1860

atgcaggccc tgccccctcg ctaa                                            1884


<210>  233
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-3C3 CAR (nucleic acid)

<400>  233
atggctctgc ctgttactgc tctacttctc cccctggcgc tgttgttaca cgccgcccgt       60

cccgaggtgc agctggtgga gtcggggccc ggcttggtga aaccgagtca gacgctgagt      120

ctgacctgca ccgtgtccgg agctagcatc actaccgggg agttctattg gaactggttc      180

cgacagccgc ctggtaaagg ccttgaatgg atgggcgcca tcgcggcctc cggctcgacc      240

acctactccc cgtctttcga gagccgcacg tctatctccc gggatacctc cgagaaccag      300

ttctacctcc agctttcgtc ggtgactcct gaagacacgg ccgtctacta ctgtgggaga      360

tcttttggtg tggctgctgt gaccaccggc cagaaccgcg gtcaaggcac ccaggtcacg      420

gtatcctctg gcggcggggg atccggtgga ggcggctccg gtgggggggg atcccaggtg      480

cagctggtgg agagcggcgg cggttctgtg caggcggggg gctccctgcg cctctcgtgt      540

ggcgcaagcg gcaacatcaa ctcccgcaac tgcatgggct ggttccgcca ggccccaggg      600

aaggagcggg agggcgtcgc tgcaatcggc caggtcacag gccgctctta ctacgtggac      660

agcgtgaagg gccgttttac tatctctttg gataatgcta agaacaccct gtacctgcag      720

atgaatactc tgaagcctga ggacactgcc atgtattact gtgcagcggc tcccgggtgc      780

ctgctgagcg cgctccgctc agcggactac aggaactggg gccagggcac acaggttacc      840

gtgtccagtg gcggcggtgg ctccggcggc ggtggaagcg gcgggggagg gtctcaaatt      900

cagcttgtcg aaagcggcgg tggcctggtg cagccgggcg gttccctgcg cctgtcatgc      960

gccgcctccg gcttcacgtt ttcaaattac ccaatgacct ggctacgcca ggcacccggt     1020

aagggtctgg agtcggtgtc tgacatcacc agcggaggtg ataggcccta ttacgcggac     1080

tccgtcaagg gccgcttcac cattagccgt gacaacgcca agaacatgct gtacctcgag     1140

atgaactctc tgaagaccga ggacaccgcc gtgtactact gtgccacctg ggaccgcacc     1200

ctcactggac agggcaccca ggtcacagta tcttccacta gtaccacgac gccagcgccg     1260

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1320

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1380

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1440

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1500

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1560

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1620

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1680

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1740

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1800

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1860

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1914


<210>  234
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-3C4 CAR (nucleic acid)

<400>  234
atggccctgc ccgtgactgc tctgctgttg cccctggcgc tgcttctgca cgcagcgagg       60

cctgaggtgc agctggtgga gtccggaccc gggctggtaa agccctctca gactctttcc      120

ctgacctgca ctgtctcagg cgcttccatc accacagggg agttctattg gaattggttc      180

cgccagccgc ctggcaaagg cttggaatgg atgggcgcca tcgcggcttc tgggtcgacc      240

acctactccc cgtcctttga gagtaggact tctatcagcc gcgatacctc cgagaaccag      300

ttctacttgc agctgtcatc cgtgactcct gaagacaccg ccgtctacta ctgcgggcgc      360

tcgtttggtg tggccgccgt tacaaccggc cagaaccgcg gccagggcac ccaggtcaca      420

gtgtcctccg gaggaggcgg atctggaggt ggtggttctg gtggcggcgg ttctggcggc      480

ggaggcagcc aggtgcaact ggtggagagt ggggggggct ccgtacaggc cggcggctct      540

ctgcgcctgt cgtgtggagc atcgggcaac attaactccc gcaactgcat ggggtggttc      600

agacaggccc ctggcaagga gcgggagggc gtggcggcta tcggtcaggt taccggccgc      660

agctactacg tggattctgt gaagggccgc ttcaccatct cactggacaa cgccaagaac      720

acgctctacc tgcagatgaa cacgctcaag ccagaggaca ctgccatgta ttactgtgcc      780

gctgctccgg ggtgcctgct gtccgccctg cgttccgcgg actaccggaa ttggggccag      840

ggcactcagg tcaccgtcag cagcggtggg ggcggcagcg gaggaggtgg aagcggtggc      900

ggcggctccg ggggtggggg ctctcaaatt cagttggtgg agagtggtgg cggcctcgtg      960

cagccagggg gctcccttcg actgtcgtgt gctgcatccg gcttcacgtt tagcaactat     1020

ccgatgacct ggctacgcca ggctcccggg aagggtctgg agagcgtgag tgacatcacc     1080

tctggcggtg atcgtcccta ttacgcggac agcgttaagg gccgcttcac catctctcgc     1140

gacaacgcga aaaacatgct ttacctcgag atgaactccc tgaagaccga ggacacggcc     1200

gtgtactact gtgccacctg ggaccgcacg ctcaccggcc agggcaccca ggtcaccgtg     1260

tcgtccacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1320

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1380

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1440

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1500

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1560

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1620

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1680

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1740

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1800

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1860

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1920

atgcaggccc tgccccctcg ctaa                                            1944


<210>  235
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-4C1 CAR (nucleic acid)

<400>  235
atggcgctac cggtgacggc actgctgctg cccctggcgc tgctgttgca cgccgctcgc       60

cctgaggtgc agctggtgga gtccgggccc ggtctggtta agcctagcca gaccctgtcc      120

ttaacctgca ctgtatctgg cgcatccatc actaccggcg agttctattg gaactggttc      180

agacagccac ccggcaaagg cctcgaatgg atgggcgcta tcgcggcctc tggctcgacc      240

acctactccc catcctttga gtcccgcacc tctatttcac gggacaccag cgagaaccag      300

ttttatctgc agctctcctc tgtgactcct gaggatactg cggtgtacta ctgcgggcga      360

tccttcggag tggccgctgt cacaaccggt cagaaccgcg gacaggggac ccaggtcacc      420

gtgtcgtccg gaggtggggg ttcgcaaatc cagctcgtgg agagtggcgg aggcctggtg      480

cagccgggag gatcccttcg cctgtcttgt gccgccagcg gctttacatt cagcaactac      540

cccatgacct ggctccgtca ggccccgggc aagggcctgg agtccgtgtc cgacatcacc      600

agcggagggg acaggcccta ttacgcggac tccgtgaagg gccgcttcac catctcgcgc      660

gacaatgcca agaacatgct ttacctggag atgaactccc tgaagacgga agataccgcc      720

gtgtactact gtgccacttg ggatcgtacc ctcaccggcc aaggcactca ggttaccgtc      780

tcctctggtg gcggcggtag tcaggtccag ttggttgaga gcgggggcgg ttcagtgcag      840

gcaggtggct ccctgcgtct tagctgtggt gcttccggca acattaacag ccgcaactgc      900

atgggctggt tccgccaggc ccctgggaag gagcgggagg gcgtggctgc catcgggcag      960

gtcaccgggc gcagctacta cgtggacagt gtaaaaggcc gattcaccat ctctctggac     1020

aacgcgaaga acactctgta cttgcagatg aacacgctga agcccgagga cacggccatg     1080

tattactgtg ctgcggctcc ggggtgcctg ctgtctgccc tgcgctcggc cgactacagg     1140

aattggggcc agggcaccca ggtgacagtc tctagcacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  236
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-4C2 CAR (nucleic acid)

<400>  236
atggccctcc cagtgacggc ccttctgctg cctttggctc tgctgttgca cgccgcccgc       60

cctgaggtgc agttggtgga atctgggccg ggtttagtca agccgagcca aactctgagc      120

ctcacctgca cagttagtgg cgcttccatc accaccggag agttctattg gaattggttt      180

cgccagccac cgggcaaagg cctggagtgg atgggcgcta tcgcggcttc cgggtccacg      240

acctactcgc cctccttcga gtcacgaacc agcatctctc gggacacatc cgagaaccag      300

ttctacctgc agctgtcctc cgtgacccct gaagatactg cggtctacta ctgtgggcgc      360

tcctttggcg tggcagccgt gactaccggc cagaaccgcg gacagggcac ccaggtcacc      420

gtgtcctctg gcggaggagg ctcagggggc ggtggctcgc agatccagct ggtggagtcg      480

ggaggcgggc tggtacagcc cggcggctct ctgcgcctgt cctgtgcagc ttcgggcttc      540

acgttcagca actacccgat gacctggctc cgtcaggccc ccggcaaggg tctggagagc      600

gtcagcgaca tcacctccgg gggtgaccgc ccctattacg cggattcagt aaagggtcgt      660

tttacaatct cccgcgacaa tgccaagaac atgctgtacc tggagatgaa ctccctcaag      720

accgaggaca ccgcggtcta ctactgtgcc acctgggaca ggactctgac cggacagggc      780

acccaggtga ccgttagctc cggcggcggt ggatcggggg gtggtggctc acaggtgcag      840

ctggtggaga gcggcggcgg tagcgtgcag gctggcggat cccttagact gtcttgcggg      900

gcctctggca acattaactc tcgcaactgc atgggctggt tccgtcaggc tcccggtaag      960

gagcgggagg gcgtcgctgc tatcggtcag gtgaccgggc gcagctatta cgtggattct     1020

gtgaagggac gcttcacgat ttccctcgac aacgccaaaa acacgcttta cctacagatg     1080

aacaccctaa agcccgagga cactgcgatg tattactgtg ccgcggctcc tgggtgcctg     1140

ctcagtgcct tgaggtctgc agactaccga aactggggcc aaggtactca ggtcactgtg     1200

agttcgacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1260

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1320

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1380

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1440

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1500

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1560

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1620

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1680

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1740

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1800

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1860

atgcaggccc tgccccctcg ctaa                                            1884


<210>  237
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-4C3 CAR (nucleic acid)

<400>  237
atggcgctgc ccgtcactgc tctcctgctt cccctggccc tgttgctaca cgccgctcgt       60

cccgaggtgc agcttgtgga gtcgggaccc ggcctcgtaa agccctctca aactttgagc      120

ctgacctgta ctgtctctgg cgctagcatt accacaggcg agttctattg gaactggttc      180

agacagccac cggggaaagg cctagagtgg atgggcgcca tcgcggcttc cgggtccacg      240

acctactcgc cctctttcga gagtcgaacc tctatcagcc gtgacacatc cgagaaccag      300

ttttacctgc agctgagttc cgtgactccg gaggacaccg cagtctacta ctgtgggcgc      360

tccttcggcg tggcagcggt caccaccggc cagaaccgcg gccaggggac ccaggtcact      420

gtgagttccg ggggcggagg ctcgggcggc ggcggttccg gcggcggagg ctcccagatc      480

cagctggtgg aaagcggcgg tgggctggtg cagccgggtg gctccttgcg cctgtcatgc      540

gccgcttctg gcttcacctt ttcaaattac ccaatgacct ggctccgcca ggccccgggc      600

aaaggtcttg aatctgtatc tgacatcacc agcggagggg acaggcctta ttacgcggac      660

tccgttaagg gccgcttcac catctcccgg gacaacgcca agaatatgct ctacctggag      720

atgaactccc tgaagactga ggatacggcc gtgtactact gtgccacctg ggaccgcacc      780

ctgacgggac agggcaccca ggttaccgtg agctctggtg gtggaggttc cggcgggggt      840

ggctccggag gaggcggtag ccaagtgcag ctggtggaga gcggtggcgg ttctgtgcag      900

gccggcggca gcctgcgcct gtcatgcggg gcctcgggca acattaactc ccgcaactgc      960

atggggtggt tccgccaggc tcctggcaag gagcgcgagg gcgtggccgc tatcggccag     1020

gtcaccggcc gaagctacta cgtggattct gtgaagggcc ggtttaccat ctctctggac     1080

aacgcgaaga acactctgta cttgcagatg aacacgctca agcctgaaga caccgccatg     1140

tattactgtg ctgcggcccc tgggtgcctg ctgagcgcgc ttcgtagcgc agattacagg     1200

aactggggcc agggtaccca ggtcacagtg tcctccacta gtaccacgac gccagcgccg     1260

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1320

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1380

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1440

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1500

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1560

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1620

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1680

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1740

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1800

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1860

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1914


<210>  238
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-4C4 CAR (nucleic acid)

<400>  238
atggccctgc ctgtcacggc cctcctgctg cccctggcgc tgttgctcca cgccgctcgt       60

cccgaggtgc agctggtgga gagtgggcca gggttggtga agccctctca gacgcttagt      120

ctgacctgca ctgtatctgg cgcttctatc actaccggcg agttctattg gaattggttc      180

agacagcccc cgggaaaggg tctggaatgg atgggggcta tcgcggcttc cgggtcgacc      240

acctactccc catcctttga gagccgcacc agcatctctc gcgacacctc ggagaaccag      300

ttttacctgc agctgtcttc cgtgacccct gaagacaccg ccgtgtacta ctgtggacgc      360

tccttcggcg ttgcggcggt gaccacaggc cagaaccgcg gacagggcac tcaggtcact      420

gtgagctctg gaggaggagg ctctggcgga ggcggcagcg gtggcggcgg gtctggaggc      480

ggcggctccc aaattcagct ggtggagtcg ggcggcggcc tggtgcagcc gggcggtagt      540

ctacgcctgt catgtgccgc ctcgggcttt acgttcagca actaccctat gacctggctc      600

cgccaggccc ctggcaaagg gctggagagt gtttccgaca tcaccagcgg tggtgatagg      660

ccctattacg cggacagcgt caagggccgc ttcacgatct cgcgggacaa cgcgaaaaac      720

atgctgtacc tggagatgaa ctcccttaag accgaggata ctgccgtgta ctactgtgcc      780

acctgggaca ggactctcac cggccaggga acccaggtca ccgtgtcgtc cggtgggggt      840

ggttctggcg gtggcggctc cggcgggggc ggctccgggg ggggcggctc acaggtgcag      900

cttgtggaga gcggcggagg ctccgtgcag gcaggtggct ccttacgatt gtcatgcggg      960

gcctcaggca acattaactc ccgcaactgc atgggctggt tccgccaggc cccgggcaag     1020

gagcgcgagg gcgtggctgc catcggtcag gtcacaggtc gtagctacta cgtggattct     1080

gttaagggcc gcttcaccat ctccttggac aatgccaaga acactcttta cctccagatg     1140

aacacgctga agccggagga cactgccatg tattactgtg ctgctgcacc cgggtgcctg     1200

ctgtccgccc tgcgcagcgc ggactaccgg aactggggcc aaggcaccca ggtcaccgtc     1260

tcctccacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1320

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1380

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1440

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1500

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1560

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1620

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1680

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1740

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1800

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1860

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1920

atgcaggccc tgccccctcg ctaa                                            1944


<210>  239
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-5C1 CAR (nucleic acid)

<400>  239
atggctctgc ccgtcacggc tttactgttg cccctggcgc tgctgctgca cgccgcacgg       60

ccacaaattc agctggtaga gagtggaggc ggcctcgtgc agccgggcgg ctcgctgcgc      120

ctttcctgtg ctgcttccgg cttcacattt tcaaattacc cgatgacctg gctacggcag      180

gccccgggaa agggtctgga gagcgtgtcc gacatcacct ctggaggtga ccgtccctat      240

tacgcggaca gcgtgaaggg ccgcttcacc atctctcgtg acaacgcgaa aaacatgctg      300

tacctggaga tgaactccct gaagaccgag gacactgccg tctactactg tgcgacctgg      360

gaccgcactc tcactggtca gggcacccag gtcacagttt cttctggggg gggaggctcc      420

caggtccaac tggtggagag cggtggtggc tccgtgcagg ccggcggatc tcttcgtctg      480

tcatgcgggg cttccggcaa catcaactcc cgcaactgca tgggctggtt cagacaggcc      540

cccggcaagg agcgcgaggg cgtggcggca atcggtcagg tgaccggtcg cagctactac      600

gtggattctg tgaaaggtag gtttaccatt agcttggata acgccaagaa cacgctttac      660

ctgcagatga acacgctcaa gcctgaggac accgccatgt attactgtgc ggctgcaccc      720

gggtgcctgc tctcggccct acggagtgcg gactacagga attggggcca gggcacccag      780

gtcacggtat cctctggcgg gggcggttcg gaggtgcagt tggtggagag cggccctggc      840

ctggtgaagc cctctcagac tctgtctctg acctgcaccg tgtccggtgc ttccatcacc      900

acaggcgagt tctattggaa ctggttccgc cagccacctg ggaagggctt agaatggatg      960

ggcgccatcg cggcctccgg ctccacgacc tactccccgt ccttcgaatc ccgaactagc     1020

atctcgcgcg acaccagcga gaaccagttt tacttgcagc tgagcagtgt tactcctgaa     1080

gataccgccg tgtactactg tgggcgctcc ttcggcgtgg ctgccgttac caccggccag     1140

aaccgcggac agggcaccca ggtgaccgtc agctcgacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  240
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-5C2 CAR (nucleic acid)

<400>  240
atggccctgc ctgttactgc gctcctactg cccctggctc tgctgttgca cgccgcccgt       60

cctcagatcc agctagtgga gtctggcggg ggtctggtgc agccaggggg cagccttcgc      120

ttgtcctgtg ctgcttctgg ctttacgttc agcaactacc cgatgacctg gctccgccaa      180

gctcccggca aaggactgga gagcgtgtcc gacatcactt cgggggggga caggccctat      240

tacgcggaca gcgtgaaggg ccgcttcacc atttctcgtg acaacgccaa gaacatgctg      300

tacctggaga tgaactcctt aaagaccgag gatacggccg tctactactg tgccacctgg      360

gaccgcactc tgaccggcca aggcacccag gtcaccgtgt cctctggcgg cggtggttct      420

ggaggaggcg gttcacaggt gcagctcgtg gagagcggtg gtgggtccgt acaggccggc      480

ggctccctgc gactgtcatg cggggcatct ggcaacatta actcccgcaa ctgcatgggc      540

tggttcagac aggcccctgg caaggagcgg gagggcgttg ctgctatcgg tcaggtcaca      600

ggacgcagct actacgtgga ttctgtaaag ggccgcttca ccatctcgct cgataacgcg      660

aaaaacactc tttacttgca gatgaacacg ctgaagcctg aagacactgc catgtattac      720

tgtgctgcag cccccgggtg cctgctgagt gcgctgcgct cggcggacta ccgcaattgg      780

ggccagggga cccaggtcac cgtgtcgtcc ggtggtggcg gcagtggagg cggcgggtcc      840

gaggtgcagc tcgtggagtc gggtcccggc cttgtcaagc ccagtcagac tctttctctc      900

acctgcactg tgagcggcgc atctatcaca acgggcgagt tctactggaa ttggttccgc      960

cagccgccgg gcaagggcct ggaatggatg ggcgccatcg cggcctccgg ctcgaccacc     1020

tactccccat cctttgagag ccgcaccagc atctcccgcg acacgtccga gaaccagttc     1080

tacctgcagc tgagctccgt gaccccggag gacaccgccg tgtactactg tgggcggtcc     1140

ttcggcgtgg cggctgtgac cacaggacag aacaggggac agggcaccca ggtcaccgtc     1200

tcttcgacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1260

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1320

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1380

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1440

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1500

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1560

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1620

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1680

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1740

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1800

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1860

atgcaggccc tgccccctcg ctaa                                            1884


<210>  241
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-5C3 CAR (nucleic acid)

<400>  241
atggctctgc ccgtgactgc tctgctgctt cccctggccc tgctgctgca cgccgctagg       60

cctcagatcc agctcgttga gagcggcgga gggctggtcc agccaggggg ctcgctgcgt      120

ctgtcctgtg ccgcctccgg ctttacgttc agtaactacc ctatgacctg gctccgccag      180

gccccgggca aaggccttga aagcgtgtcc gacatcactt caggtggtga tcggccctat      240

tacgcggaca gcgtgaaggg acgcttcacc atctcccgcg acaacgccaa gaacatgctt      300

tacctggaga tgaactccct aaagaccgag gacaccgccg tctactactg tgccacctgg      360

gaccgcactt taaccggtca aggcacccaa gtgaccgtat ctagtggcgg cggcgggtcc      420

gggggcggtg ggtcgggcgg cggaggcagc caggtgcagc tggtagagag cggaggaggg      480

tccgtgcagg ccggcgggtc tcttcgcctg tcctgcgggg cttccggtaa cattaattcc      540

cgcaactgca tggggtggtt cagacaggct cccggcaagg agcgcgaggg cgtggcggcg      600

attggccagg tcacgggccg aagctactac gtggattctg ttaagggccg ttttaccatc      660

tcgttggaca acgcgaaaaa cactctgtac ctgcagatga acacgttgaa gcctgaggac      720

acagctatgt attactgtgc agccgcaccc gggtgcctgc tgtctgcact gcgctcggcg      780

gactacagga attggggcca gggcacccag gtcaccgtgt cgtccggtgg cggaggttcc      840

ggtggaggtg gtagtggggg cggcggcagc gaggtgcagc tggtggagag cggccctggc      900

ttggtgaagc cctctcagac gctcagccta acctgcactg tctctggtgc ttccatcacc      960

acaggcgagt tctattggaa ctggttccgc cagccgccag gcaagggcct ggagtggatg     1020

ggcgccatcg cggcttctgg ttccaccact tactccccgt ccttcgagag tcgtaccagc     1080

atctcccggg acacctccga gaaccagttt tacctccagc tctcttcggt aactccggaa     1140

gataccgcgg tgtactattg tggccgcagc ttcggcgtgg ctgccgtcac cacaggacag     1200

aaccgcggac agggtaccca ggtcaccgtg tcctccacta gtaccacgac gccagcgccg     1260

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1320

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1380

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1440

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1500

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1560

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1620

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1680

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1740

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1800

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1860

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1914


<210>  242
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-5C4 CAR (nucleic acid)

<400>  242
atggccctgc ccgtgaccgc cctcttgctc cccctggctt tgctactgca cgccgctcgc       60

cctcagatcc agttggtgga gtccggcggc ggcctggtgc agccaggggg cagtcttcgc      120

ctgtcttgtg ctgcatctgg cttcacgttc tctaactacc cgatgacctg gctccgccag      180

gctccgggca agggcttgga gagcgtgtcc gacattacca gcggcggtga tcgtccctat      240

tacgcggaca gtgtcaaagg ccggtttact atctcgcgcg acaacgcgaa aaacatgctt      300

tacctggaga tgaactccct gaagactgag gataccgcgg tctactactg tgccacctgg      360

gacaggaccc tgaccggcca aggaacccag gtgaccgtga gcagtggtgg cggcggttcg      420

ggcggtggcg gctccggcgg gggcggttcc ggcggcggag gctcccaggt gcagctggtg      480

gaatctgggg ggggctcggt gcaggctggc ggttctctcc gtctgtcctg cggcgcctca      540

ggcaacatta actcgcgcaa ctgcatggga tggttcagac aggctcctgg taaggagcga      600

gagggcgtgg cggcgatcgg ccaggtcacc ggtaggagct actacgtgga ttctgttaag      660

ggccgcttca ccatctctct ggacaatgct aagaacacgc tgtacttgca gatgaacaca      720

ctcaagcctg aagacactgc catgtattac tgtgcagccg cccccgggtg cctgctgtcc      780

gctctgcgct ccgcggacta ccgcaactgg ggccaaggca cccaggtcac tgtatcctcc      840

ggaggtggcg gatctggggg aggtggttcg ggcggggggg gcagcggtgg cggagggtcc      900

gaggtgcagc tggtagagag cggcccaggc ctggtgaagc cctcgcagac gctgtctctt      960

acctgcactg tctccggggc atctatcacc accggcgagt tctattggaa ttggttccgc     1020

cagccgcctg ggaagggact ggagtggatg ggggccatcg ccgcctccgg tagtacgacg     1080

tactcaccct cctttgagtc tcggactagc atcagccggg acacctcgga gaaccagttt     1140

tacctgcagt taagctccgt gactccggag gacactgccg tgtactactg tggccgttcc     1200

ttcggtgttg ccgccgtgac cacaggacag aaccgcggcc agggcaccca ggtcacagtc     1260

agctctacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1320

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1380

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1440

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1500

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1560

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1620

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1680

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1740

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1800

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1860

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1920

atgcaggccc tgccccctcg ctaa                                            1944


<210>  243
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-6C1 CAR (nucleic acid)

<400>  243
atggccctgc ccgtcactgc actgctcctt cccctggctc tcctcctgca cgccgctcgc       60

cctgaagtgc agttggtgga gtctgggggc ggcttagtgc aggctggcgg ttctctccgc      120

ctgtcgtgtg ccgcgtccgg acgcaccttc tccagctaca acatgggctg gtttcgccag      180

gccccaggta aggagaggga gttcgtcgcg gtggtggatt ggtctggagg gtcgccctat      240

tacgcagact ccgtgaaggg ccgcttcacc atctctcgtg acaatggcaa gaataccgta      300

tacctacaga tgaactccct taaacctgaa gatactgccg tgtactactg tgctggccgc      360

gttcaatacg gctcaagttg gtctggtgat tattggggcc agggcaccca ggtgactgtg      420

agcagcggcg gaggcggaag ccaggtccag ctggtggaga gcgggggggg ctcggttcag      480

gccggaggaa gtctgaggtt gtcatgcggc gcgtctggca acattaactc ccgcaactgc      540

atgggctggt tccgccaggc cccgggcaag gagcgcgagg gcgtcgcagc tatcggtcag      600

gtcaccggcc ggtcttacta cgtggacagt gtgaaaggcc gttttacaat ctccctggac      660

aacgcgaaga acactctgta cttgcagatg aacacgctga agccggaaga cactgccatg      720

tattactgtg ccgctgctcc ggggtgcctg ctgtccgccc tgcgcagcgc ggactaccgg      780

aactggggcc aaggcaccca ggttaccgtg tcctcaggtg gtggtgggag cgaggtgcag      840

ctggtggaga gcggacccgg cctggtgaag ccctctcaga cgcttagtct gacctgcacc      900

gtgtccggcg catccatcac cacaggtgag ttctattgga actggttccg tcagccgcca      960

ggtaagggac tggagtggat gggcgccatc gcggcctccg gctccaccac ctactcccct     1020

tcgtttgagt cgcgcaccag catttcccgg gacacctccg agaaccagtt ctacctgcag     1080

ctctcctccg tcacgcccga ggacaccgcc gtctactact gtgggcgctc cttcggcgtg     1140

gcggccgtaa caaccggtca gaaccgcggt caggggaccc aggtcaccgt atctagcact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  244
<211>  1905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-6C2 CAR (nucleic acid)

<400>  244
atggcgctgc cggtgactgc tctcctgctg cccctggccc tgctgctcca cgccgctcgt       60

cctgaagttc agctggtaga gagcggcggt ggcctcgtgc aggccggcgg ctctcttcgt      120

ctttcatgcg ccgcgtccgg gcgcaccttc tccagctaca acatggggtg gttccgccag      180

gccccaggta aggagaggga gttcgtcgcc gtggtggact ggtctggtgg tagtccctat      240

tacgcggaca gcgtcaaagg cagattcacc atttcacgtg acaacggcaa aaacaccgtg      300

tacctgcaga tgaactccct caagcccgag gacacggcag tgtactactg tgctgggcgt      360

gtgcagtacg gctccagttg gtctggggac tattggggcc agggcaccca ggtcaccgtg      420

tcctccgggg gtggtggctc ggggggcggc ggatctcagg tccagttagt ggagagcggt      480

ggaggctccg tgcaggccgg aggctctctg cgcctgtcat gtggggcgtc cggcaacatt      540

aattcccgga actgcatggg ctggttccgc caggcccccg gcaaggagcg cgagggcgtt      600

gcagctatcg gtcaggtgac tggccgcagc tactacgtgg attctgtgaa gggacgcttc      660

accatctcgt tggataacgc caagaacacg ctttacttgc agatgaatac cctgaagccg      720

gaagacaccg ccatgtatta ctgtgccgcc gctcccgggt gcctgttgag cgcattgcgg      780

tccgcggact accgcaactg gggccagggc acccaggtca ccgtctcgtc tggaggtgga      840

ggatcgggcg gtggcggctc ggaggtgcag ctggtagaga gcgggcccgg cctcgtcaag      900

ccttcccaga ctctgagcct gacctgcact gtatctggcg cttccatcac caccggcgag      960

ttctattgga attggtttcg acagccgcct ggaaagggcc tggagtggat gggcgccatc     1020

gcggcttctg gctcaacgac ctactcccca tcctttgaga gccgcaccag catctctcgc     1080

gacacctccg agaaccagtt ttacctgcaa ctaagctccg tgacgcctga agatacagct     1140

gtctactact gtgggcgctc cttcggcgtg gcggcagtga caacaggaca gaaccgcggc     1200

caaggtaccc aggtcaccgt gagctcgact agtaccacga cgccagcgcc gcgaccacca     1260

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     1320

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg     1380

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1440

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1500

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1560

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1620

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1680

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1740

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1800

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1860

gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa                     1905


<210>  245
<211>  1935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-6C3 CAR (nucleic acid)

<400>  245
atggccctcc cggtgactgc gctgctgctg cccctggccc tactgcttca cgccgctagg       60

cccgaggtgc agctggtgga gagtggaggc gggctggtgc aggctggcgg ttcgcttcgt      120

ttatcatgcg cagctagtgg acggaccttt tcatcctaca acatgggctg gttccgccag      180

gcccccggca aggagcgcga gttcgtcgcg gtggtggact ggtctggcgg gtccccctat      240

tacgcggaca gcgtgaaggg ccgtttcacc atctcccgcg acaacggtaa gaacacggtc      300

tacctgcaga tgaactccct caagcctgaa gatacggccg tgtactactg tgctgggcga      360

gtgcagtacg gctctagttg gtctggggac tattggggcc agggtacaca ggttaccgtc      420

tcgagtggcg gaggcggctc tgggggcggc ggctccggtg gcggcggctc ccaggtgcag      480

ctggtggaat ccggcggcgg ctccgtgcag gccggcggct ccctgcgcct gtcatgcggg      540

gccagcggga acattaattc tcgcaactgc atgggatggt ttagacaggc tcctggaaaa      600

gagagggagg gcgtggctgc tatcggtcaa gtaaccggtc gcagctacta cgtggactcc      660

gttaagggtc gtttcaccat cagcttggac aacgcgaaga acactctgta cctccagatg      720

aacacgctca agccagagga caccgccatg tattactgtg ccgcagcccc tgggtgcctg      780

ttgagcgcgc ttcgttccgc ggactaccgg aattggggcc agggcaccca ggtaacagtg      840

agctccggtg gcggcggctc cggtggcggc gggtctgggg gtgggggctc ggaggtgcag      900

ttggtggaga gcgggcccgg gcttgtcaag ccctctcaga ctctgtccct gacctgtacc      960

gtgtccggtg ctagcatcac caccggcgag ttctattgga actggttccg ccagccaccg     1020

ggcaaaggtc tggagtggat gggcgccatc gcggcctcgg gttctacaac ctactcccct     1080

tcgtttgaga gccgcacctc tatttcccgc gataccagcg agaaccagtt ctacctgcaa     1140

ctgagctccg taactccgga ggatactgcc gtgtactact gtggccgctc cttcggcgtt     1200

gcagctgtca cgaccggtca gaaccgcgga cagggaaccc aggtcaccgt ctcctcgact     1260

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1320

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1380

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1440

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1500

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1560

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1620

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1680

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1740

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1800

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1860

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1920

ctgccccctc gctaa                                                      1935


<210>  246
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-6C4 CAR (nucleic acid)

<400>  246
atggctttgc cggtgaccgc cctgctcctg cccctggcgc tgcttctgca cgccgctcgt       60

cctgaagtgc agctggtgga gtctgggggg ggcctcgtgc aggctggagg tagcttgcgt      120

ctgagctgtg ctgcctccgg ccgcacgttc tcgtcctaca acatggggtg gttccgccag      180

gccccaggta aggagaggga gttcgttgcc gtggtcgatt ggtctggggg gtccccctat      240

tacgctgact ccgtcaaagg caggtttacc atctcccgcg acaacggcaa gaacacggta      300

taccttcaga tgaactccct gaagccggag gacaccgccg tgtactactg tgcaggacga      360

gtgcagtacg gctccagttg gtctggggac tattggggcc agggcaccca ggtgaccgtg      420

tcctctggcg ggggaggctc cggtggtggc ggatccggcg gcggcggctc cggcggcggt      480

ggctcccaag tacagctggt ggagtctggc ggcggaagcg tccaggccgg aggctcactt      540

cgcctgtcat gtggcgctag cggcaacatt aacagccgca actgcatggg ctggttccgc      600

caggcgccgg gcaaggagcg cgagggcgtg gccgccatcg gtcaggtaac tggtcgcagc      660

tactacgtgg attctgttaa aggacgcttc accatcagtt tggacaacgc caagaatacc      720

ctgtacctgc agatgaatac cctcaagccc gaggacactg ccatgtatta ctgtgcggcg      780

gccccagggt gcctgctgtc agccctgcgc tccgcggact accggaactg gggccaaggt      840

acccaggtca ccgttagctc cggaggcggt ggatcgggcg gcggcggcag cggtggtggg      900

ggttcaggcg gtggggggtc cgaggtgcag ctggtggaga gtgggcctgg tttagtgaag      960

ccctctcaga ccctgtccct gacctgcact gtctccgggg caagcatcac cactggcgag     1020

ttctattgga attggttcag acagcccccc gggaagggcc tagagtggat gggcgccatc     1080

gcagcttccg gctcgaccac ctacagtcct tctttcgaga gccggaccag catttctcgg     1140

gacacgtcgg agaaccagtt ttacctccag ctgtcgagcg tgacacctga agatactgcg     1200

gtgtactact gcgggcgtag ttttggcgtc gctgccgtga cgaccggcca gaaccgcgga     1260

cagggtaccc aggtcacagt ctcttctact agtaccacga cgccagcgcc gcgaccacca     1320

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca     1380

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgatat ctacatctgg     1440

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     1500

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     1560

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1620

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1680

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1740

cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1800

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1860

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1920

gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa                     1965


<210>  247
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-7C1 CAR (nucleic acid)

<400>  247
atggccctgc ccgtcactgc gctgctgctg cccctggccc tgctcctgca cgccgctcgt       60

cctcaggtcc agttggtgga gagcggaggc ggcagcgtgc aggccggcgg atcccttcgc      120

ctgagctgtg gtgcatctgg caacattaac tcccgcaact gcatgggctg gttcagacaa      180

gcgccgggga aggagcgcga gggcgtggcg gcaatcggtc aggtgaccgg ccgcagctac      240

tacgtggatt ctgtgaaggg gcgtttcacc atcagtttgg ataacgccaa gaacacgctt      300

tacctgcaga tgaacactct gaagcccgaa gatactgcca tgtattactg tgctgcagct      360

ccgggctgcc tgctgagcgc gctgcgaagc gcggactacc ggaactgggg ccagggtacc      420

caggttactg tctcctctgg cggcggaggc tcccaaattc agcttgtgga gagtggggga      480

gggttagtgc agccaggcgg ctccctgcgc ctgtcatgcg ccgcctccgg cttcaccttt      540

tcaaattacc caatgacctg gctccgtcag gcccccggca aaggcctgga gtccgtgtcc      600

gacatcactt cgggtgggga caggccctat tacgcggaca gcgtaaaggg tcgttttacc      660

atctcgaggg acaacgcgaa aaacatgctg tacctggaga tgaatagtct caagaccgag      720

gacacggccg tgtactactg tgccacctgg gaccgcacac ttaccggtca ggggacccag      780

gtcaccgtgt cgtcgggcgg cggcggttct gaggtgcagc tggtagagag tggtcctggt      840

ctagtcaagc cttcacagac gctatccctg acctgcaccg tgtccggtgc ttctatcacc      900

accggcgagt tctattggaa ttggttccgc cagccgccgg gaaagggcct cgagtggatg      960

ggggctatcg cagcttccgg ctcgactacc tactctccct cttttgagtc gcgcacaagc     1020

atctcccggg acacctccga gaaccagttc tacttgcagc tctcctccgt tacgcctgaa     1080

gacactgccg tgtactactg tggacgctcc ttcggcgtgg ctgccgtcac gacaggccag     1140

aaccgcggac agggcaccca ggtcaccgtg agctccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  248
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-7C2 CAR (nucleic acid)

<400>  248
atggccctgc cggtgactgc tctacttctg cccctggcgc tgctgctcca cgccgcccgc       60

cctcaggtgc agctggtgga gagcggagga ggttctgtgc aggccggcgg ttctctgcgc      120

ctgagttgtg gtgcatcggg caacattaac agccggaact gcatgggatg gttcagacag      180

gcccccggca aggagcgcga gggcgtggct gctatcggtc aggtcaccgg tcgcagctac      240

tacgtggaca gcgtcaaagg tcgcttcacc atctctttgg ataacgccaa gaacacgctt      300

tacctccaga tgaatactct gaagcctgaa gatacggcca tgtattactg tgctgcagcc      360

cccgggtgcc tgctgagcgc gcttcgatcc gcggactacc gcaactgggg ccagggcacc      420

caggttaccg tgagctccgg cgggggcggt tctggtggcg gaggctccca aattcagttg      480

gtggagtcgg gcggaggttt ggtgcagccg ggcggttctt tgcgtctgtc atgcgctgcg      540

tctggcttca ccttttcaaa ttatccgatg acctggctcc gccaggcccc tggcaaaggc      600

ctggagagcg tgtccgacat cactagcggc ggggacaggc cctattacgc ggactccgtg      660

aagggcaggt ttactatctc gcgggacaac gctaagaata tgctgtacct ggagatgaac      720

tccctcaaga ccgaggatac cgccgtctac tactgtgcta cctgggaccg cacgctgacg      780

ggccaaggaa cgcaggtcac cgtcagttcc ggtgggggcg gctccggggg cggcggcagc      840

gaggtgcagc tggtggagag tgggccaggc cttgtaaagc cctctcagac tctatctctg      900

acctgcactg tctccggcgc ttctatcacc acaggcgagt tctattggaa ctggttccgc      960

cagccacccg ggaagggtct cgaatggatg ggcgccatcg cggcctctgg gtcgaccacc     1020

tactccccgt cctttgagag ccgtactagc atctcccgcg acacctccga gaaccagttc     1080

tacctgcagc tgtcctccgt aacacctgag gacaccgccg tgtactactg tgggcgttcc     1140

ttcggcgtgg cggcagttac aaccggacag aaccgcggac agggcaccca ggtcaccgtg     1200

tcctccacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1260

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1320

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1380

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1440

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1500

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1560

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1620

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1680

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1740

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1800

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1860

atgcaggccc tgccccctcg ctaa                                            1884


<210>  249
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-7C3 CAR (nucleic acid)

<400>  249
atggcgctcc cggtgaccgc tttgctgctg cccctggcgc tgctgcttca cgccgctcgc       60

cctcaggtgc agttggtgga gagcggtggc ggctccgtgc aggccggcgg ctccttacgt      120

ctgtcatgcg gggcctcggg caacattaac agccgcaact gcatggggtg gttccgccag      180

gcccctggca aggagcgcga gggggtggct gccatcggtc aggtcaccgg ccgctcctac      240

tacgtggaca gcgtcaaggg tcgcttcacc atctcacttg ataacgcgaa aaacactctt      300

tacctgcaga tgaatacgct caagcccgag gacacggcca tgtattactg tgccgctgct      360

ccggggtgcc tgctctccgc cctgcgctcc gccgactaca ggaactgggg ccagggcacc      420

caggtcacag tctcttctgg tggtggcggg tccggcggcg ggggttcggg cggcggtggc      480

tctcaaattc agctagtaga gtctggcggc gggctggtgc agccgggcgg cagcctgcgc      540

ctgtcctgtg ctgcttccgg cttcacattt tcaaattacc ccatgacctg gctccgccag      600

gcgcccggga agggattgga atcggtgtcc gacatcactt ccggtggtga taggccctat      660

tacgcggaca gcgtgaaggg ccgttttacc atctctcggg acaacgccaa gaacatgcta      720

tacctggaga tgaactccct gaagacggag gacaccgccg tctactactg tgccacctgg      780

gaccgcaccc tgactggaca aggcacccag gttaccgtgt ccagcggggg tggaggaagc      840

ggtggtggcg gtagcggcgg cggcggctcg gaggtgcagc tggtggagtc tggccctgga      900

ctcgttaaac cgtcccagac gctttctctg acctgcactg tatctggagc atctatcacc      960

acaggcgagt tctattggaa ttggttcaga cagcccccag ggaagggcct ggagtggatg     1020

ggcgccatcg cagcttctgg ctccaccacc tactccccat cctttgagag tcgaaccagc     1080

atctcccgcg acaccagcga gaaccagttc tacttgcagc tgagttccgt gactcctgaa     1140

gatactgccg tgtactactg tggacggtcc ttcggggtgg cggccgtgac gaccggtcag     1200

aaccgcggtc aggggaccca ggtcaccgtc tcatccacta gtaccacgac gccagcgccg     1260

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1320

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1380

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1440

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1500

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1560

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1620

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1680

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1740

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1800

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1860

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1914


<210>  250
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-7C4 CAR (nucleic acid)

<400>  250
atggccctgc cggtgacggc cctacttctg cccctggcgc tgctgctgca cgccgccagg       60

cctcaggtcc aactggtgga gagcggcggc ggttccgtgc aggccggcgg ctcgttgcgt      120

ctgagctgtg gggcttccgg caacattaac tcccgcaact gcatggggtg gttccgccag      180

gctcccggca aggagcgcga gggcgtcgca gctatcggtc aggtcactgg tcggagctac      240

tacgtggact ccgtaaaagg ccgttttacc atctctttgg acaacgccaa gaacacgctg      300

tacctgcaga tgaacactct caagcctgag gataccgcca tgtattactg tgccgcggcg      360

cccgggtgcc tgctgtccgc tctgcgctcg gccgattacc ggaattgggg ccagggcacc      420

caggtcaccg tgagctcggg tggcggaggc tccgggggtg gaggctccgg cggagggggc      480

tctgggggcg gtggatctca aattcagttg gtggagagcg gcggtgggct ggtgcagcca      540

gggggtagcc tgcgcttgtc ttgcgccgcg tctggcttca cattttcaaa ctaccccatg      600

acctggttac gacaggcccc tggcaagggc ctcgagagcg tgtccgacat cacgagcggt      660

ggggacaggc cctattacgc ggactctgtg aagggccgct tcaccatctc tcgtgacaat      720

gctaaaaaca tgctttacct ggagatgaac tccttgaaga ccgaggacac cgccgtgtac      780

tactgtgcta cctgggaccg caccctcacc ggccagggca cccaggtgac tgtatcctcc      840

ggcggtggcg gcagcggagg cgggggcagt ggcggtggtg gctccggtgg aggaggctcg      900

gaggtgcagc tggtggaaag tgggccgggc cttgttaagc cctctcagac tcttagcctc      960

acctgcactg tcagcggtgc tagcatcacc acaggcgagt tctattggaa ctggttcaga     1020

cagccgccag gaaagggtct ggagtggatg ggcgccatcg cggcatctgg ctcgaccacc     1080

tactccccgt catttgagtc tcgcacctcc atctcgcgcg acacctccga gaaccagttc     1140

tacctccagc tgtcctccgt gacacctgaa gataccgcgg tgtactactg tggccgctcc     1200

ttcggcgtgg cggctgtcac gaccggtcag aaccgcggac aggggactca ggttacggtc     1260

tcttccacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1320

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1380

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1440

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1500

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1560

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1620

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1680

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1740

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1800

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1860

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1920

atgcaggccc tgccccctcg ctaa                                            1944


<210>  251
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-8C1 CAR (nucleic acid)

<400>  251
atggcgctgc ccgtcactgc tttgctactg cccctggccc tgctgttaca cgccgcccgt       60

cctcaggtgc agttggtgga gagcgggggt ggctccgtgc aggcgggtgg atctttgaga      120

ctctcttgtg gcgcctcggg caacattaac tcccgtaact gcatggggtg gttccgccag      180

gccccgggca aggagcgcga gggcgtggct gccatcggtc aggtcaccgg tcgcagctac      240

tacgtcgatt ctgtaaaggg ccgcttcacc atctctctgg acaacgctaa gaacacgctt      300

tacctgcaga tgaacactct gaagcctgaa gacacggcca tgtattactg tgccgctgct      360

cccgggtgcc tgctgtccgc gctccgctcg gcggactacc gcaactgggg ccagggtacc      420

caggtcacag tctcttctgg gggaggcggg tcggaggtgc agctggtcga gagcgggccg      480

ggccttgtga agccgtctca gactctgtca cttacctgca ctgtgagcgg cgcatccatc      540

actaccggcg agttctattg gaactggttc cgccagccac ccggcaaagg tctggagtgg      600

atgggcgcta tcgcggcttc cggctcgacc acctactccc cctccttcga gtcgcgtacc      660

tctatctccc gggacacctc cgagaaccag ttctacctcc agctgagctc cgtgactccg      720

gaagatacgg cagtatacta ctgcgggcga tccttcggtg tggcggcagt tacaacggga      780

cagaaccgcg gccagggcac ccaggtcacc gtgagctctg gaggaggagg ctcccaaatt      840

cagctggtgg agagcggcgg cggccttgtg caacctggcg gctccctgcg cctgtcctgt      900

gctgctagcg gcttcacatt ttcaaattac cccatgacct ggctacgtca ggcccctggt      960

aaaggcttgg aaagcgttag tgacatcacc agcggggggg acaggcccta ttacgcggac     1020

agtgttaagg gtaggtttac tatctcccgg gataacgcca agaatatgct gtacctggag     1080

atgaactccc tcaagaccga ggacaccgcc gtgtactact gtgccacctg ggaccgcacg     1140

ctgaccggcc agggcaccca ggtgaccgtg tcgtcgacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  252
<211>  1884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-8C2 CAR (nucleic acid)

<400>  252
atggctctcc ccgtgactgc tctcctcctg cccctggcct tactgctgca cgccgcccgg       60

cctcaggtgc agttggtgga gtccggcggc gggtccgtac aagcaggggg atctttgcgt      120

ctgtcttgtg gcgccagcgg caacattaac tcgcgcaact gcatggggtg gttcaggcag      180

gccccgggca aggagcgaga gggcgtggct gccatcggtc aggtcaccgg tcgcagctac      240

tacgtggatt ctgtcaaggg ccgctttacc atttctctgg ataacgcgaa gaacacgctg      300

tacctccaga tgaacactct gaagcccgag gacacggcca tgtattactg tgcagctgcg      360

cccgggtgcc tgctgtccgc cctgcgctcg gcagactacc gcaactgggg ccaaggcacc      420

caggtgacgg tgagctccgg cggtggcggc tcgggtggcg gaggatcgga ggtgcagctt      480

gtggagagtg ggccgggctt ggtgaagcca tcacagacgc tgagcctgac ctgcactgtc      540

tccggggcct ccatcaccac cggcgagttc tattggaatt ggttcagaca gccgcctggc      600

aaaggccttg agtggatggg cgctatcgca gcttccggct cgaccaccta ctccccttcg      660

tttgagagcc gtacatccat cagccgcgac actagcgaga accagttcta cctgcagctg      720

tcctccgtaa cacctgaaga caccgcggtg tactactgcg ggcgttcctt cggcgtggcg      780

gctgttacga ctggccagaa ccgcggccag ggaacccagg tcaccgtcag ttctggcggt      840

ggcggttccg gtggaggtgg ctcccagatc cagctggtgg agtctggtgg tggtctggtg      900

cagccaggcg gatcgctgcg cctgagttgt gcggcttctg gcttcacatt ttctaactac      960

cccatgacct ggctccgcca ggccccggga aagggtctgg agtccgttag tgacatcacc     1020

agcggcgggg acaggcccta ttacgcggac agcgtcaaag ggcgtttcac catctctcgg     1080

gacaacgcca agaatatgtt gtacctggag atgaatagcc ttaagaccga agataccgcc     1140

gtgtactact gtgccacctg ggaccgcacc cttactggcc agggcaccca ggtcaccgtg     1200

tcctcaacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1260

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1320

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1380

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1440

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1500

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1560

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1620

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1680

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1740

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1800

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1860

atgcaggccc tgccccctcg ctaa                                            1884


<210>  253
<211>  1914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-8C3 CAR (nucleic acid)

<400>  253
atggctttgc cggtgactgc tcttcttctg cccctggcgc tgctgctgca cgccgcccgc       60

cctcaggtgc agctggtcga gagcggtgga ggctcagtgc aggcaggcgg cagcttgcgt      120

ttgtcctgtg gcgcatctgg caacattaac tcccgcaact gcatgggatg gttcagacag      180

gccccgggaa aggagcgcga gggcgtcgcc gctatcggtc aagtcactgg ccgtagctac      240

tacgtggatt ctgtgaaggg ccgcttcaca atctctctgg ataacgcgaa gaacacactg      300

tacctgcaga tgaacacgct aaagcccgaa gacacggcca tgtattactg tgctgctgct      360

cccgggtgcc tgctgtccgc cctgcgcagt gcggactacc ggaactgggg ccagggaacc      420

caggttacag tctcctccgg ggggggtggt tctggagggg gcggttcggg tggcggcggt      480

tccgaggtgc agttggtgga gtcaggaccc ggcctggtaa aaccctcaca gactctttcc      540

ctcacctgca ctgtgagcgg cgcctctatc accacaggcg agttctattg gaactggttc      600

cgccagccgc ctggtaaagg cctggagtgg atgggcgcca tcgccgcctc tggatccacc      660

acctacagcc cgtcgtttga gagccgaacc agcatctcgc gggacacctc cgagaaccag      720

ttttacctcc agctgtctag tgtcactcct gaagataccg cagtgtatta ctgtgggcgc      780

tccttcggtg tggcggctgt aacgaccggc cagaacaggg gccagggcac ccaggtgacc      840

gtgtcctctg gaggcggcgg atccgggggc ggggggagcg gtggtggcgg ctctcaaatt      900

cagctagttg agagtggcgg gggactcgtg cagccaggcg gctccctgcg cctgtcgtgt      960

gcggcgagcg gctttacgtt cagcaactac ccaatgacct ggctacgcca ggcccctggc     1020

aagggtctcg agtccgtgtc cgacatcact tccggcgggg acaggcccta ttacgcggac     1080

agcgtgaagg gccgtttcac catcagtcgt gacaatgcca agaatatgct ctacctggag     1140

atgaactccc tgaagactga ggacaccgcc gtgtactact gcgccacctg ggaccgcacc     1200

ctgaccggcc agggcaccca ggtcaccgtc tcgtctacta gtaccacgac gccagcgccg     1260

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1320

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1380

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1440

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1500

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1560

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1620

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1680

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1740

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1800

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1860

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1914


<210>  254
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-8C4 CAR (nucleic acid)

<400>  254
atggccctgc cggtgaccgc gctactgctg cccctggcac tgttactcca cgccgctcgc       60

cctcaggtgc agttggtgga gagtggcggt ggctccgtgc aggccggcgg tagcctgcgc      120

ctgtcttgcg gggcctcggg caacatcaac agccgcaact gcatggggtg gttcagacag      180

gctcctggta aggagcgcga gggcgtcgca gctatcggtc aagtgaccgg gcgttcctac      240

tacgtggata gtgttaaagg ccgtttcacc atctcgctgg acaacgcgaa aaacacactg      300

tacctgcaga tgaatactct taagcccgag gacacagcca tgtattactg tgctgccgcc      360

cccgggtgcc tgctgtccgc cttgcggagc gcggactacc ggaattgggg ccaggggacc      420

caggtcacgg tttcctccgg cggcgggggc tccggcgggg ggggtagtgg cggcggcggc      480

tcgggcggcg gcggctcgga ggtgcagcta gtggagagtg ggccgggcct ggtgaagcca      540

tcacagactc tgagtctgac ctgcactgtc agcggcgctt ccatcactac tggcgagttc      600

tattggaatt ggttccgcca gccgcctggc aagggcctcg aatggatggg cgccatcgcg      660

gcctctggat cgaccaccta ctccccctct tttgagtccc gcacttctat ctctcgggac      720

acctccgaga accagtttta cttgcagctc agctcagtga cacctgaaga tactgcagtg      780

tactactgtg gccgctcctt cggcgtagct gctgtcacca caggacagaa ccgcggccag      840

ggtacccagg taacggtgtc gtccggtgga ggcggatccg gagggggtgg ctctggcggt      900

ggcgggtccg gtggtggcgg atcccaaatt cagctggtgg agagcggtgg cgggcttgtg      960

cagccaggtg gctctctccg actcagctgt gccgcgtctg gctttacgtt cagcaactac     1020

ccgatgacct ggctgcgcca ggcccccggg aagggtttgg agagcgtgtc ggacatcacg     1080

tccggaggcg acaggcccta ttacgcggac agcgtcaagg gacgcttcac catttctcgt     1140

gacaacgcca agaacatgct ttacctggag atgaactccc tgaagaccga ggataccgcg     1200

gtgtactact gtgctacgtg ggacaggacc ctgaccggcc agggcaccca ggtcaccgtc     1260

tcctctacta gtaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     1320

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     1380

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     1440

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1500

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1560

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1620

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1680

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1740

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1800

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1860

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1920

atgcaggccc tgccccctcg ctaa                                            1944


<210>  255
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-9C1 CAR (nucleic acid)

<400>  255
atggcccttc cagtgacagc cctgctgcta cccctcgccc tgctgcttca cgccgctagg       60

cctgaagtgc agctggtaga gtcaggcggg ggtctggtcc aggccggagg ctccctgcgc      120

ctgtcctgtg cggctagcgg ccgcacgttc tctagctaca acatgggctg gttccgccag      180

gcgcccggaa aggagcgcga gttcgtcgcc gtggttgatt ggtctggagg atccccctat      240

tacgcggact ccgtaaaggg ccgcttcact atctcccggg ataacggcaa gaacacggtg      300

tacctgcaga tgaatagcct aaagcctgag gacactgccg tgtactactg tgctgggcgt      360

gtgcagtacg gcagcagttg gtctggcgat tattggggcc agggcaccca ggttacggtg      420

agttccggtg gcggaggctc ggaggtgcag ttggtggaga gcggtccagg tctcgtgaag      480

ccctctcaaa ccctgtcgct gacctgcacc gtgtccggcg ctagtatcac caccggcgag      540

ttttattgga actggttcag acagccgcct ggaaaaggcc tggagtggat gggcgctatc      600

gccgcgagcg gctcgaccac ctactcccct tcgtttgaat ccaggacctc tatttcccgg      660

gacacctccg agaaccagtt ctacttgcag ttgtcctctg tgaccccgga ggacacagcg      720

gtgtactact gtgggcgatc cttcggggtc gccgccgtga ccactggcca gaaccgcggc      780

cagggtaccc aggtcaccgt gtcatccggc ggtgggggat cccaggtgca gctggtggag      840

agcggcggcg gttctgtcca ggcagggggt tccttgcgct tatcgtgcgg ggcctcgggc      900

aacattaatt ctcgcaactg catggggtgg ttccgtcaag ctcccggcaa ggagcgcgag      960

ggcgtggcgg caatcggtca ggtcacaggc cgtagctact acgtcgacag cgtcaagggc     1020

cgcttcacca tctctctgga caacgctaaa aacactctgt acctgcagat gaacacgctc     1080

aagccggaag acaccgccat gtattactgt gcagcggctc ccgggtgcct gctctccgct     1140

ctccgcagtg ccgactaccg caattggggc cagggtaccc aggtgactgt ttcaagcact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  256
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-10C1 CAR (nucleic acid)

<400>  256
atggctctgc cggtgactgc gctgcttctg cccctggctc tactgctgca cgccgcgcgc       60

cctgaggtgc agcttgtcga gagcggcccc ggcttagtta agccctctca gaccctgagc      120

ctgacctgca ctgtgagcgg tgcatccatc acaaccgggg agttctattg gaactggttc      180

cgccagcccc cgggtaaagg tctggagtgg atgggggcca tcgccgcctc tggaagtacc      240

acttactccc cgtccttcga gagccgtacg tctatctccc gggacacctc cgagaaccag      300

ttttacttgc agttgagttc ggtgaccccc gaagatacag cagtctacta ctgtgggcga      360

tcctttggag tggccgctgt cacgaccggc cagaacaggg gacagggcac ccaggttacc      420

gtgtcgagcg gaggtggcgg ctcccaggtt caactggtgg agagcggcgg aggatccgta      480

caggccggcg gctctctcag actgtcctgc ggcgctagcg gcaacattaa tagccgcaac      540

tgcatgggct ggttccggca agcgcctggt aaggagcgcg agggcgtggc ggctatcgga      600

caggtgaccg gtcgcagcta ctacgtagac tctgtgaagg gtcgcttcac catctctctg      660

gacaacgcca agaacacgct gtacctgcag atgaatactc taaagcccga ggacaccgcc      720

atgtattact gtgccgcggc tccagggtgc ctgctttccg ctttgcgctc ggcggactac      780

aggaactggg gacagggtac ccaggtcacc gtgtcctctg ggggcggcgg ctccgaggtg      840

cagctcgtgg aatctggggg cggcctcgtc caggccggcg gctccctccg cctgtcatgt      900

gctgcctcgg gtcgcacgtt ctcctcctac aacatgggct ggttccggca ggctccaggc      960

aaggagcgtg agttcgtggc ggtggtcgat tggtctggcg gcagccctta ctacgcggac     1020

tccgtaaagg gccgttttac catttcccgc gataatggca aaaacaccgt gtacctgcag     1080

atgaactccc tgaagcctga agacactgcc gtgtattact gtgcaggtcg cgtgcagtac     1140

ggctcaagtt ggtctgggga ctattggggc caggggaccc aggtcacagt gagctcgact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  257
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-11C1 CAR (nucleic acid)

<400>  257
atggccctcc cggtgaccgc gcttctgctg cccctggcgc tgctgctgca cgccgctcgc       60

cctgaagtgc aactggtgga gagtggacct ggtcttgtga agccctcaca gacgctgagt      120

ttgacctgca ctgtatctgg tgcgtctatc accacgggcg agttctattg gaattggttc      180

cgccagccgc cggggaaagg cctggagtgg atgggcgcca tcgcggcttc cggtagtaca      240

acctactccc catccttcga gagccgcacc agcatctcgc gggacacctc cgagaaccag      300

ttctacctac agctgagctc cgttactccg gaggacaccg ccgtgtacta ctgtggcaga      360

tcctttggcg ttgccgcggt cactaccgga cagaaccgcg gacaaggcac ccaggtcact      420

gtctcttcgg gcggaggcgg ctcggaggtg cagttggtgg agagcggtgg tgggctagtg      480

caggcaggcg gttctctccg cctttcatgc gccgcctccg gccgcacctt ctcctcttac      540

aacatggggt ggttccgcca ggcccccggc aaggagaggg agttcgtcgc tgtggttgac      600

tggtctggcg gttcgcccta ttacgcggac agcgtcaagg gccgcttcac catctctcgc      660

gacaacggca aaaacacagt ctacctgcag atgaactccc tgaagcccga ggacaccgca      720

gtgtactact gtgctggtcg cgtgcagtac ggctccagtt ggtctgggga ctattggggc      780

caggggaccc aggtcaccgt gtcgtccggt ggcgggggta gccaggtgca gctggtggag      840

agcggaggcg gctccgtgca ggccgggggc tccctgcgcc tgtcctgtgg ggcttctggc      900

aacattaact cccgtaactg catgggctgg tttcgacagg ctcccggcaa ggagcgcgag      960

ggcgtggcgg ccattggaca ggtcaccggc cgtagctact acgtggattc tgtaaagggc     1020

cgatttacca tctcgttgga taatgccaag aacactctgt acctccagat gaacacgctc     1080

aagcctgaag atactgccat gtattactgt gccgcagctc cagggtgcct gctctccgcc     1140

ctgcgcagcg cggactacag gaactggggc cagggtaccc aggtgaccgt gtcgtccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  258
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-12C1 CAR (nucleic acid)

<400>  258
atggcgctgc cggtgacagc cctcctgctg cccctggcgc ttctgttaca cgccgctcgc       60

cctcaggtcc agctggtgga gagcgggggc ggctccgtgc aggccggtgg ttctcttcgt      120

ctatcatgcg gggcgtcggg caacattaac agccgcaact gcatgggatg gttccgccag      180

gctccgggaa aggagcgcga gggcgtcgca gccatcggtc aggtcactgg gcgctcctac      240

tacgtggatt ctgtgaaggg ccgttttacc atttctctgg acaacgcgaa aaacaccctg      300

tacctccaga tgaacacgct caagcccgaa gataccgcca tgtattactg tgcggcagct      360

cccgggtgcc tgctctccgc tttgcgcagc gcggactaca ggaattgggg ccaaggtacc      420

caggtcaccg tgtcatctgg aggcggcggc tccgaagtgc aattagtgga gagcggaggc      480

ggtttggtgc aggccggcgg tagtctgcgc ctgagctgtg ctgcctccgg tcgtacgttc      540

agcagctaca acatgggctg gtttcgccag gccccgggca aggagcggga gttcgtcgcc      600

gtggtcgact ggtctggcgg atccccctat tacgcggaca gcgtcaaggg ccgcttcacc      660

atctctcggg acaacggtaa gaacacggtg tacctgcaga tgaactccct gaagcctgaa      720

gacactgccg tgtactactg tgccggccgc gtgcagtacg gctccagttg gtctggtgat      780

tattggggcc agggcaccca ggtgaccgta tcctctgggg ggggcggctc ggaggttcag      840

ctggtggaga gcggccctgg ccttgttaag ccatcccaga ccctgtccct gacctgcact      900

gtttcagggg cttccatcac cacaggagag ttctattgga attggttcag acagccaccc      960

ggcaaaggcc tggagtggat gggcgctatc gcagccagcg gctcgaccac ctactccccc     1020

tcttttgaga gtcgaaccag catcagccgc gacacttctg agaaccagtt ctacctgcag     1080

ctctcgtccg tgactccgga ggacaccgcc gtctactact gtgggaggtc cttcggggtg     1140

gcggccgtga cgaccggcca gaaccgcggg cagggtaccc aggtaaccgt gtcctccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  259
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AIO-13C1 CAR (nucleic acid)

<400>  259
atggcgcttc ctgtgacggc gctgctgctg cccctggcgc tcttgcttca cgctgcccga       60

cctcaggtgc aattagtgga atcggggggg ggttccgtgc aggcaggtgg cagcctccgc      120

ctctcttgtg gtgcttccgg taacattaat tcgcgcaact gcatgggctg gttccgccag      180

gcgccgggca aggagaggga gggcgtggcc gccatcggcc aggtgaccgg acgcagctac      240

tacgtggatt ctgtgaaagg caggtttaca atttctttgg ataacgcgaa aaacacgctg      300

tacctgcaga tgaacactct gaagccagag gacaccgcca tgtattattg tgccgccgca      360

cccgggtgcc tgctgtccgc tctccgctcg gccgactaca gaaattgggg ccagggaact      420

caggtcaccg tcagctctgg tggcggtggc tccgaggtgc agctggtaga gtccggtccg      480

ggcctggtga agcctagtca gacactatct ctgacctgca ctgtctctgg cgcgtcaatc      540

acaaccggcg agttctactg gaactggttc cgccagcccc caggcaaggg cctggagtgg      600

atgggggcta tcgcagctag cggctctact acctacagcc ctagctttga gagccggacc      660

tccatctcgc gtgacacgtc cgagaaccag ttctacctgc agctgtcctc ggtcaccccg      720

gaagacaccg ccgtgtacta ctgtgggcgg tccttcggcg ttgccgcggt gaccactggg      780

cagaaccgtg gacagggcac ccaggtgacc gtgtcgtccg gaggcggcgg ctctgaagtg      840

cagcttgtgg agagcggtgg aggcctggtg caggccggcg gatcactgcg cctgtcatgc      900

gccgccagcg ggcgcacctt tagtagctac aacatgggct ggttcagaca ggctcccggg      960

aaggagcgcg agttcgtcgc cgtggtcgac tggtccgggg ggtcccccta ttacgcagac     1020

tcggttaagg gacgcttcac catctcccgc gacaacggta agaacacggt ctatctccag     1080

atgaactcct tgaagcccga ggacacggcc gtgtactact gtgctggccg tgtacagtac     1140

ggcagtagtt ggtctggcga ttactggggt caaggcaccc aggttactgt ctccagcact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  260
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-100 CAR (nucleic acid)

<400>  260
atggctctgc ccgtcactgc cctgctgctc cccctggcgc tgctgctaca cgccgctcgc       60

cctcaggtgc agctggtgga gtcgggcggc gggctggtgc agccaggggg ctccctccgc      120

ctgtcatgcg cggcttccgg caacattaac tcccgcaact gcatgggctg gttcagacag      180

gctcccggca aaggcaggga gggcgtggcg gcaatcggtc aggtcacagg acgcagctac      240

tacgtggaca gcgtaaaggg ccgcttcacc atctccttgg ataactccaa gaacacgctg      300

tacttgcaga tgaactccct ccgagccgaa gatacagcag tgtactactg tgctgccgcc      360

cccgggtgcc tgctttcggc gctccgctcc gccgattaca ggaactgggg ccagggcact      420

ctggtcacgg tatctagtgg gggcggaggc tcccaggtcc agctacagga gagcggaccc      480

ggcctcgtca agcccagcca gaccctgtcc ctgacctgca ctgtgagcgg cgccagcatc      540

acgaccggcg agttctattg gaattggttc cgccagccgc ctggcaaggg tctggagtgg      600

atgggggcta tcgcggcctc cggctccacc acctactccc cgtcctttga gagccgcact      660

tctatctctc gagatacctc caaaaaccag ttttcactga agctgtcttc cgtaactgcg      720

gcggacaccg ccgtgtacta ctgcgggcgc tccttcggtg tggctgcggt gaccaccggt      780

cagaaccgcg gccagggcac cctggtaacg gtctcttctg ggggtggcgg ttctcaaatt      840

cagctgctgg agagtggcgg cggcctggtg cagccgggag gatctctgcg cctgtcatgc      900

gccgcttctg gcttcacgtt ctctaactac ccgatgacct ggatccgcca ggccccgggg      960

aagggtttgg aatccgtgtc cgacatcacc agcggagggg acaggcccta ttacgcggac     1020

tccgtgaagg gccgtttcac catctcacgg gacaacgcca agaatatgct ttacctgcag     1080

atgaacagcc tgcgcgccga ggacaccgcc gtgtactact gtgccacctg ggaccgcacc     1140

ctttggggcc aagggaccat ggtgaccgtg tcgtccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  261
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-133 CAR (nucleic acid)

<400>  261
atggcgctgc cggtgacggc gctgctgctg cccctggccc ttcttctcca cgccgccagg       60

cctcaggtgc agctggtgga gagcggaggc gggctggttc agccaggggg ctccctccgc      120

ctgtcatgcg ccgcttctgg caacattaat tcccgcaact gcatggggtg gttccgccag      180

gcccctggca aaggcaggga gggcgtggcg gcaatcggtc aggtcactgg ccgcagctat      240

tacgtggaca gcgtgaaggg ccgtttcacc atctccttgg ataactccaa gaacacgctt      300

tacctgcaga tgaactccct acgcgcggaa gacaccgcag tgtactactg tgctgcagcc      360

cccgggtgcc tgctgtccgc cctgcgctcg gcggactacc ggaactgggg ccagggaaca      420

ttggtcaccg tctccagtgg gggcggcgga agccaagtgc agctacagga gagcgggccg      480

ggactggtga agccgtccca gaccctgtca ttaacctgca ctgtgagcgg tgcttccatc      540

actaccggcg agttctattg gaactggttc agacagccgc ccggcaaggg tctggagtgg      600

atgggcgcca tcgcggcttc cggctccacg acctactccc cctcttttga gagccgcacc      660

tctatcagcc gtgacacctc caaaaaccag ttctctctga agctgtcctc cgtgactgct      720

gcggacacgg ccgtctacta ctgcgggcgc tccttcggtg tggctgctgt caccaccggc      780

cagaaccgcg gccagggcac cctggtgacc gtctcctctg gaggaggcgg ctcccaaatt      840

cagctggtag aatccggtgg gggtttggtg cagccaggcg gcagcctgcg tctatcctgt      900

gcggcgtcag gcttcacgtt cagcaactac cccatgacct ggctccgcca ggctcccgga      960

aagggcctcg agtccgtgtc cgacatcacc tcgggcggtg atcggcccta ttacgctgat     1020

tctgtaaagg gacgcttcac catctctcgg gacaacgcca agaatatgct gtacctccag     1080

atgaactcgc tgcgcgccga ggacaccgcc gtgtactatt gtgccacctg ggaccgcact     1140

ctgaccggtc agggtactat ggtgaccgtg tcgtccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  262
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-167 CAR (nucleic acid)

<400>  262
atggcgcttc cggtgaccgc gctgctgctg cccctggccc tgcttctgca cgccgcccgt       60

cctcaggtgc agcttgtgga gtctggaggc ggtctggtgc agccaggggg ttctctgcgt      120

ctgtcatgcg ccgcctctgg caacattaac agccggaact gcatgggctg gttcagacag      180

gccccgggca agggcaggga gggcgtcgcc gccatcggtc aggtcactgg acgcagctac      240

tacgtggaca gtgtcaaggg ccgtttcacc atctcgctgg acaactccaa gaacacgctg      300

tacctccaga tgaactccct gcgcgccgag gacaccgccg tgtactactg tgcggcagcg      360

ccggggtgcc tgctcagcgc gctccggtca gcggactacc gcaactgggg ccagggcacc      420

ctggtgaccg tatcttctgg tggtggcggc tcccaggtcc agctgcagga gagtgggccg      480

ggtctcgtga agcctagcca gacgctatct ctgacctgca ccgtgtccgg tgcttctatc      540

accacaggcg agttctattg gaattggttc cgccagccac ccgggaaggg gctggagtgg      600

atgggcgcta tcgccgctag cggctccacg acctactccc catccttcga gtcccgcacc      660

agcatcagcc gcgacacctc taaaaaccag ttcagcctga agctgagttc cgtgactgct      720

gcggacactg cggtgtacta ctgcgggcgc tcgtttggcg tggcggctgt caccaccggc      780

cagaaccgcg gacagggtac tctggttacc gtgtcgtccg gaggcggcgg ctcccaaatt      840

cagctggtgg agagcggcgg gggccttgtt caacctggtg gctccttgcg cctgagctgt      900

gctgcttccg gcttcacgtt cagcaactac cccatgacct ggctccgcca ggcccctggc      960

aaaggcctcg agtcagtgtc ggacatcacc tccggtgggg acaggcccta ttacgcggac     1020

agcgtgaaag gccgcttcac catctctcgt gacaacgcca agaatatgct gtacctgcag     1080

atgaactccc tccgcgctga agatactgcc gtgtattact gtgccacctg ggatcgaacc     1140

cttaccggac agggcaccct ggtcaccgtc tcgtctacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  263
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-180 CAR (nucleic acid)

<400>  263
atggccctgc cagtgactgc tctgctgctg cccctggcgc tgctgctcca cgccgcccgc       60

cctcaggtcc agcttgtgga gagtgggggc gggctggtgc agccgggggg ctccctgcgc      120

ctgtcctgtg ccgcttctgg caacattaac tcccgcaact gcatgggctg gttcagacag      180

gccccgggca agggaaggga gggcgtggct gccatcggtc aggtcaccgg tcgctcgtac      240

tacgtggaca gtgtcaaggg ccgtttcaca atttctctgg acaactccaa aaacacgctg      300

tacctgcaga tgaactcctt gcgtgccgag gacaccgctg tatattactg tgcggcagct      360

cccgggtgcc tgctttcggc gctccgctcc gccgactaca ggaattgggg ccaaggcacc      420

cttgtcaccg tgtcctctgg tgggggcggc tcccaggtgc agttgcagga gagcggaccc      480

ggcctggtga agccctctca aaccctcagc ctgacctgca ccgtgtccgg cgccagcatc      540

accacaggcg agttctattg gaattggttc cgccagccgc ctggcaaagg cctggagtgg      600

atgggcgcta tcgctgcttc cggttccacc acctactccc cctcgtttga gagccgcacc      660

tccatctccc gcgacaccag caagaaccag ttttcactga agctgagctc cgtgacagcg      720

gcggacacgg ccgtgtacta ctgcgggcgc tccttcggtg tggcggccgt cacgaccggc      780

cagaaccgcg gacagggcac cctggtgacc gtgtcttctg ggggcggagg ttccgaggtg      840

cagctggtgg agagcggcgg tggactggtg cagccaggtg gctcgctgcg cctgtcatgc      900

gccgcatcgg gccgcacctt ctcaagctac aacatggggt ggttccgaca ggcccccgga      960

aagggcctcg agtgggtcgc cgcggtggac tggtctggcg gctcccccta ttacgcggac     1020

tctgtgaagg gacgcttcac catctcgcgg gacaactcca agaacacggt ctacctccag     1080

atgaactccc tgcgcgctga agataccgcc gtgtactact gtgctggccg cgtgcagtac     1140

ggctccagtt ggtctggtga ttattggggc caggggaccc tggttaccgt gtcctccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  264
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-203 CAR (nucleic acid)

<400>  264
atggcgctgc cagtgactgc tctgctgctg cccctggccc tgctgctcca cgccgctagg       60

cctcaggtac aattggtgga gagcggcggt ggtctcgtgc agccaggggg tagcctgcgt      120

ctatcctgtg ctgcttccgg caacattaat tcccgcaact gcatgggctg gttccgccag      180

gcccccggca aaggtaggga gggcgtggct gccattggac aggtcaccgg tcgcagctac      240

tacgtggatt ctgttaaggg ccgcttcacc atctctttgg ataactccaa gaatactctt      300

tacctccaga tgaactcctt acgcgccgaa gataccgccg tgtactactg tgccgcagcc      360

ccggggtgcc tgctgagtgc tctgcggtct gcggactacc gcaactgggg ccagggcacc      420

ctcgtgaccg tgtcatcggg gggaggcggc tcacaggtgc agttgcagga gagtgggccc      480

ggcttggtaa agccttccca gactctgtcc ctgacctgca ctgtgagcgg cgctagcatc      540

accaccggcg agttctattg gaactggttc agacagccgc ctggcaaggg tctggagtgg      600

atgggcgcca tcgcggcctc cgggtccacg acctactccc cgtccttcga gagccgcacc      660

tccatctctc gggacacttc caagaaccag ttttcactga agctgagctc cgtgacggcg      720

gcggacaccg ccgtgtatta ctgcgggcgc tcgtttgggg tggcggctgt caccacagga      780

cagaaccgcg gtcaggggac ccttgtcacc gtgtcgtcgg gcggcggggg ctccgaggtg      840

cagctggtag aatccggtgg cggtctggtg cagccgggcg gttcactgcg cctgtcatgc      900

gccgcaagtg gccgtacgtt ctccagttac aacatggggt ggttcagaca ggcccccgga      960

aagggcctcg agttcgtcgc ggtggtcgac tggtctggcg gctcgcccta ttacgcggac     1020

agcgtgaagg gaaggtttac catctcgcgc gacaacagca aaaacacggt ctacctgcag     1080

atgtcttctc tccgcgcgga ggacacagcc gtgtactact gtgccggccg agtgcagtac     1140

ggctccagtt ggtctgggga ctattggggc cagggcaccc tggtgaccgt ctccagcact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  265
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-213 CAR (nucleic acid)

<400>  265
atggcgctgc ctgtgactgc tctgcttctg cccctggccc tactgctgca cgccgccagg       60

cctcaggtcc agctggtgga gagtggcggg ggggtggtgc agccaggtcg ctctctgcgc      120

ctgtcatgcg ccgcttccgg caacattaat tcccgcaact gcatgggctg gttccgccag      180

gcccccggca agggccgcga gggcgtggcg gctatcggtc aggtcaccgg tcgcagctat      240

tacgtggact ccgtgaaggg acgcttcacc atctcgttgg ataactccaa aaacacgctg      300

tacctccaga tgaacagcct acgggccgaa gacaccgccg tgtactactg tgctgcagct      360

ccagggtgcc tgctcagcgc gctccgctcg gcggactaca ggaactgggg ccaggggacc      420

ctggtgaccg tgtcctctgg aggcggtggc tctcaagtgc agttgcagga gagcgggccc      480

gggctggtaa agccctctca gactctttcg ctgacctgca ctgtctctgg cgccagcatc      540

accaccggcg agttctattg gaactggttc cgccagccgc ctggcaaagg cctcgaatgg      600

atgggggcca tcgcggcctc gggctccacg acctactccc cgtccttcga gagccgcacc      660

tccatctctc gcgacaccag caagaaccag ttttcactga agctgtcctc ggttactgcg      720

gcggacactg ccgtctacta ctgcgggcgt tcctttggtg tggctgctgt cacaaccgga      780

cagaaccgcg gacagggcac cctggtcacc gtcagctccg gtggtggcgg ctccgaggtg      840

cagctggtgg agagcggagg aggtttggtg caaccgggcg gctccctacg gctcagttgt      900

gcagctagcg gtcgtacgtt ctccagctac aacatgggct ggttcagaca ggccccgggt      960

aagggcctgg agtgggtcgc agccgtggat tggtctgggg gttcccccta ttacgcggac     1020

agcgtcaagg gaaggtttac gatttctcgt gacaactcca agaatacagt gtacctgcag     1080

atgaactcct tgcgcgccga ggacaccgcg gtgtactact gtgccggccg agtgcagtac     1140

ggctccagtt ggtctggtga ttattggggc cagggcaccc ttgtgacggt gtcgtcgact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  266
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-217 CAR (nucleic acid)

<400>  266
atggctctgc ctgttaccgc cctactgctg cccctggcgc tgctgctcca cgccgctcgc       60

cctcaggtgc agcttgtgga gagcggcggt ggtgtggtgc agcctgggcg ctcgctgcgg      120

ctgtcatgcg ccgcctcggg caacattaac tcccgcaact gcatggggtg gttccgccag      180

gccccgggga agggaaggga gggcgtggcg gctatcggtc aggtcaccgg ccgcagctat      240

tacgtggaca gcgttaaagg ccgtttcacc atctctctgg acaattccaa gaataccctg      300

tacctccaga tgaacagcct tcgtgccgag gacacggccg tctactactg tgcggccgct      360

cccgggtgcc tgctgtccgc cctgcgctcg gcggactacc ggaactgggg ccagggcacc      420

ctggtgaccg tgtcctccgg tggcggtggc tcccaggtcc agctgcagga gagtgggccg      480

ggcctcgtaa agccctctca gactctttct ctgacctgca ctgtcagcgg tgcctctatc      540

accacaggcg agttctattg gaactggttc agacagccac ccggcaaggg cttggaatgg      600

atgggcgcca tcgccgcttc cggctccacg acctactccc cgtccttcga gagccgcacc      660

agcatctccc gggacacctc caaaaaccag ttttcactga agctgtcctc cgtgactgct      720

gcggacactg cggtatacta ctgcgggaga tcctttggcg tggctgcggt gaccaccggt      780

cagaaccgcg gccaaggcac tctggttacc gtgtccagtg ggggaggcgg ctccgaggtg      840

cagctggtgg agtctggggg tggtctcgtg cagccagggg gctcgctgcg cctgagctgt      900

gccgcctccg gacgtacgtt ctcgagctac aacatgggct ggttccgcca ggcccccggc      960

aaaggtctgg agttcgtcgc tgtggtcgat tggtctggag gatctcccta ttacgcggac     1020

agtgtgaagg gccgcttcac catttctcgc gacaactcca agaacacggt gtacctgcag     1080

atgtcttctt tgcgcgccga agataccgca gtgtactact gtgctggccg cgtgcaatac     1140

ggctccagtt ggtctggtga ttattggggc caggggacct tggtgaccgt gagctccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  267
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-227 CAR (nucleic acid)

<400>  267
atggcgctgc cggtgactgc tctgctgctg cccctggccc tgctcctaca cgccgcccgc       60

cctcaggtgc agttgcagga gagcggccct ggtctcgtaa agccctcaca gacgctttcg      120

ctgacctgca ctgtcagcgg cgcctccatc accacagggg agttctattg gaattggttc      180

agacagccac ccggtaaggg cctcgaatgg atgggggcca tcgcggcttc tggttcgacc      240

acctactccc cctcttttga gagccgcacc agcatctcgc gcgacacctc caaaaaccag      300

ttctctctga agctgtcctc cgtgaccgct gcggacaccg ccgtgtacta ctgcgggcgc      360

tccttcggtg tggcggccgt cacgaccggc cagaaccgcg gacagggcac ccttgtaacc      420

gtatcttctg gaggaggcgg ctcccaggtt caactggtgg agagtggagg cggtttggtg      480

cagccaggag gcagtctgcg cctttcatgc gccgcatccg gcaacattaa ctcccgcaac      540

tgcatgggct ggttccgcca ggcccccggc aagggcaggg agggcgtggc tgccatcggt      600

caggtcaccg gtcgctcgta ctacgtggac agcgtgaagg gaaggtttac catctctctg      660

gacaattcca agaacactct gtacctgcag atgaatagcc tgcgggccga ggacaccgcc      720

gtgtactact gtgccgcagc tcctgggtgc ctgctgagcg cacttcgcag cgcggactac      780

cggaactggg gccaggggac cctcgtcaca gtgagctcgg gcggaggtgg ctccgaggtg      840

cagctggtgg agagcggtgg cggcctggtg cagccggggg gctctctccg cctgtcttgt      900

gctgcttccg gacgtacgtt ctcgagctac aacatgggct ggttccgcca ggccccgggc      960

aaaggtctgg agtgggtcgc cgcggtcgat tggtctggcg gctcgcccta ttacgcggac     1020

agcgttaaag gccgcttcac catttctcgg gacaactcca agaacacggt gtacctccag     1080

atgaacagcc ttcgcgccga agatacggcc gtctactact gtgccggccg ggtccaatac     1140

ggctccagtt ggtctgggga ttattggggc caaggcaccc tggtgaccgt gtcgtccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  268
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-230 CAR (nucleic acid)

<400>  268
atggcgctgc cagtgaccgc cctgctgctg cccctggcgc tgctgctcca cgccgctcgc       60

cctcaggtcc agctgcagga gagtggaccc ggccttgtta agccctctca gactctgtct      120

ctgacctgca ccgtgtccgg tgcttccatc accaccggcg agttctattg gaactggttc      180

agacagccgc ctggcaaggg cctcgagtgg atgggcgcca ttgctgcctc cggaagtaca      240

acctactccc cgtcctttga gagccgcacc agcatcagcc gggacacctc caagaaccag      300

ttcagcctga agctgtcctc tgtgacggcc gctgacaccg ccgtctacta ctgcgggcgt      360

tccttcggcg tggctgcggt gacgaccgga cagaaccgcg gccagggcac cctggtgacc      420

gtatcttccg gcggaggggg ctcccaggtg cagctcgtgg agtctggcgg cgggctggtg      480

cagccgggcg gctccctccg tctgtcatgc gctgcttctg gcaacattaa ttcccgcaac      540

tgcatggggt ggttccgcca ggcccctggg aagggtaggg agggcgtcgc ggccatcggt      600

caggtcaccg gtcgcagcta ctacgtggac tccgtgaagg gacgcttcac catctcgttg      660

gataacagca aaaacacgct gtacctgcag atgaactccc tgcgtgcgga ggacacagcc      720

gtgtactact gtgcagccgc gccggggtgc ctgctgtccg ccctgcgctc ggcggactac      780

cgcaactggg gccaaggcac tcttgtcact gtcagctctg gaggcggtgg ctccgaggtg      840

cagctggtgg agagcggcgg agggctggtt cagccaggag gctccttgcg cctgagttgt      900

gccgcctccg ggcgcacgtt cagttcctac aacatgggct ggttccgcca ggccccgggc      960

aagggcctgg agttcgtcgc cgtggtcgac tggtctgggg gctcccccta ttacgcggac     1020

agcgtcaagg gcaggtttac tatctctcgc gacaactcca agaataccgt gtacttgcag     1080

atgtcttctc ttcgcgccga agatactgcc gtatattact gtgctggccg agtgcagtac     1140

ggctccagtt ggtctggtga ttattggggc cagggcaccc tggtgaccgt gagctccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  269
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-240 CAR (nucleic acid)

<400>  269
atggccctgc cggtgaccgc tctgctcctg cccctggcgc tgctgcttca cgccgccagg       60

cctcaggtcc aattgcagga gagtggaccc ggcctcgtta agccctctca gacgctttct      120

ctgacctgca ccgtgtccgg tgcttccatc accacaggcg agttctattg gaattggttc      180

agacagccgc ctggcaaagg cctagaatgg atgggggcca tcgcggcttc cggttcgacc      240

acctactccc catccttcga gagccgcacc agcatctccc gtgacacctc caaaaaccag      300

ttctctctga agctgtcaag tgtcactgcc gcggacaccg cggtgtatta ctgcgggcgc      360

tcgtttggtg tggcggccgt gacgaccggc cagaaccgcg gacagggtac cctggtgacc      420

gtctcttctg gtgggggtgg ctcacaggtg cagctggtgg agagcggagg cggggtggtg      480

cagccaggcc gctctcttcg gctcagctgt gctgcctctg gcaacattaa ctcccgcaac      540

tgcatgggct ggttccgcca ggctcccggg aagggccgcg agggcgtggc tgctatcggt      600

caggtcacag ggcgcagcta ctacgtggat tctgtgaagg gccgcttcac catttctttg      660

gataactcca agaacacgct gtacctgcag atgaacagcc tgcgcgccga agacacggcc      720

gtgtactact gcgccgcagc ccccgggtgc ctgctgtccg ccctgcgctc ggcggactac      780

aggaactggg gccagggaac tctggtgact gtcagctccg gcggcggcgg ctccgaggtg      840

cagctggtgg agtcgggcgg aggcctggtg cagccaggcg gctccctccg cctgtcctgt      900

gcggcttctg gccgtacgtt ctcctcttac aacatgggct ggttccgcca ggccccgggc      960

aaggggctgg agtgggtcgc cgctgtcgac tggtctggtg gcagccccta ttacgcggac     1020

agcgtcaagg gtcgcttcac catctctcgc gacaactcca agaataccgt gtacctccag     1080

atgaactccc tccgggccga ggacaccgcc gtctactact gtgccggccg agtgcagtac     1140

ggctccagtt ggtctggtga ttattggggc cagggcaccc tggtaaccgt gtcctcaact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  270
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-243 CAR (nucleic acid)

<400>  270
atggcgctcc cggtgacagc tctgcttctg cccctggccc tgctgctcca cgccgccagg       60

cctcaggtgc agcttcagga gagcggccct ggtctggtaa agccctctca gacgctttcg      120

ctgacctgca ctgtatctgg ggcttccatc accaccggcg agttctattg gaattggttc      180

cgccagccac ccggcaaagg cctcgagtgg atgggcgcta tcgcggccag cggctccact      240

acctactccc cgtcttttga gagccgcacc agcatctcgc gggacacctc caaaaaccag      300

ttcagtctga agctgagctc agtgactgct gcggacacgg ccgtatatta ctgcgggcgc      360

tccttcggag tggctgctgt caccacagga cagaaccgcg gacagggcac actggtgacc      420

gtctcctccg gcggcggagg ctcccaagtg cagctggtgg agagtggcgg cggggtggtc      480

cagccgggcc gctcgctccg cctgtcatgc gccgcttctg gcaacattaa ttcccgcaac      540

tgcatgggct ggttccgcca ggccccgggg aagggcaggg agggcgtggc ggccatcggt      600

caggtcaccg gtcgtagcta ctacgtggac agcgtcaagg gacgcttcac catttctttg      660

gataactcca agaatactct gtacctgcag atgaacagct tgagagctga agacaccgcg      720

gtctactact gtgctgcggc gcccgggtgc ctgctgtccg cgctgcgctc cgcggactac      780

cggaactggg gccagggcac cctggttacc gtgtcctctg gaggcggggg ttccgaggtg      840

cagctggtgg agagcggcgg cggactggtg cagccagggg gttccttgcg tcttagctgt      900

gccgcttccg gtcgcacctt ctcatcttac aacatggggt ggttcagaca ggcccctggc      960

aagggcctgg agttcgtcgc cgtggtggat tggtctggtg gctcccccta ttacgcggac     1020

tccgtgaagg gccgtttcac catctctcgc gacaactcca agaacacggt gtacttgcag     1080

atgtcttctc tgcgcgccga ggacaccgcc gtgtactact gtgccggccg agtgcagtac     1140

ggctccagtt ggtctggtga ttattggggc caggggaccc ttgtcaccgt gtcgtccact     1200

agtaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc     1260

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg     1320

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     1380

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     1440

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1500

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1560

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1620

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1680

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1740

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1800

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1860

ctgccccctc gctaa                                                      1875


<210>  271
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-267 CAR (nucleic acid)

<400>  271
atggcgctgc cggtgacagc tcttctgctg cccctggccc tgctgctcca cgccgcccgc       60

cctcaggtgc agctggtgga gagtggtggc ggggtggtgc agccaggccg ctcgctacgg      120

ctgtcatgcg ccgcttctgg caacattaat tcccgcaact gcatggggtg gttcagacag      180

gctcccggca agggaaggga gggcgtggct gctatcggtc aggtaaccgg tcgctcttat      240

tacgtggatt ctgtgaaggg caggtttact atcagcctgg acaactccaa gaacacgctg      300

tacctgcaga tgaactccct ccgcgccgaa gataccgccg tgtactactg tgctgcggcc      360

cccgggtgcc tgctctccgc cctgcgctcc gcagattaca ggaactgggg ccagggtact      420

cttgtcaccg tgtcttctgg tggaggcggc tcccaggtcc aattgcagga gagtggccct      480

ggcctcgtca agccctcaca gactctgtct ctgacctgca ctgtatctgg tgcttctatc      540

actaccggcg agttctattg gaactggttc cgccagccgc ccggaaaggg gctggagtgg      600

atgggcgcca tcgcggcttc cggttcgacc acctactccc cctctttcga gagccgcact      660

agcatctcgc gcgacacctc caaaaaccag ttttcactga agctgagctc cgtcactgcc      720

gcggacaccg ctgtctacta ctgcgggcga tccttcggtg tggcggccgt caccacagga      780

cagaaccgcg gacagggcac cctggtgacc gtgagctcgg ggggcggtgg ctcccaaatt      840

cagctgctgg agagcggcgg cggcctggtg cagccggggg gctccctgcg cctgtcatgc      900

gctgcctccg gcttcacgtt cagcaactac cctatgacct ggatccgcca ggcccctggt      960

aaaggcctcg agtccgtgtc cgacatcacc agcggagggg acaggcccta ttacgcggac     1020

agcgttaagg gccgcttcac catctctcgt gacaacgcca agaatatgtt gtacctccag     1080

atgaactccc tgcgtgccga ggacactgcc gtgtactact gtgccacctg ggaccgcacc     1140

ctttggggcc agggcaccat ggtgaccgtg tcgtccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  272
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-300 CAR (nucleic acid)

<400>  272
atggcgctgc ccgtcacagc tctattgctt cccctggcgc tcctcttgca cgccgctcgc       60

cctcaggtgc agctggtgga gagcggtggt ggtgtggtgc agccgggccg ctccctgcgg      120

ctttcatgcg ccgcttccgg caacattaat tcccgcaact gcatggggtg gttcagacag      180

gccccaggta agggccgcga gggcgtcgcc gccatcggtc aggtcaccgg ccgcagctat      240

tacgtggatt ctgtgaaggg acgcttcacc atctcgctgg acaactccaa aaacacgctt      300

tacctccaga tgaactccct gcgcgccgag gacaccgccg tgtactactg tgcggcggct      360

cctgggtgcc tgctgtccgc cctgcgctcc gcggactaca ggaactgggg ccagggcacc      420

ctcgtcaccg tgtcgtccgg tggtggcggt tctcaagtgc agttgcagga gagtggccct      480

ggtctcgtta agccatcaca gactctcagc ctgacctgca ctgtatctgg cgcctctatc      540

actaccggcg agttctattg gaactggttc cgccagccac ccggcaaagg tctggaatgg      600

atgggcgcta tcgcggcctc tggctcgacc acctactccc cctcttttga gagtcgaacc      660

agcatctcgc gggacacctc caagaaccag ttttcactga agctgtcctc cgtgacagca      720

gcggacactg ccgtgtacta ctgcgggcgc tccttcggcg tggctgcggt gaccacaggc      780

cagaaccgcg gacagggtac tctggtcacc gtgagctccg gaggaggggg ctcccaaatt      840

cagctggtgg agagcggcgg cgggctggtg cagccggggg gctccttgcg cctgtcttgt      900

gctgcttccg gcttcacgtt cagcaactac cccatgacct ggctccgcca ggccccgggc      960

aagggcctgg agagcgtgtc cgacatcacc tctgggggtg ataggcccta ttacgcggac     1020

agcgtcaagg gccgcttcac catctctcgc gacaatgcca agaatatgct gtacctgcag     1080

atgaactccc tgcgcgccga agatactgct gtctactact gtgccacctg ggaccgcacc     1140

ctgacgggac agggcaccat ggtgaccgtc tccagtacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  273
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-333 CAR (nucleic acid)

<400>  273
atggccctgc cggtgactgc tctgctgctg cccctggcgc tgctgctaca cgccgctaga       60

cctcaggtgc agctggtgga gtctgggggc ggggtggtgc agccgggccg aagccttcgc      120

ctgtcatgcg ccgcttccgg caacattaat tcccgcaact gcatggggtg gttcagacag      180

gcccctggca aaggcaggga gggcgtggct gccatcggtc aggtcaccgg ccgcagctac      240

tacgtggatt ctgtgaaggg ccgcttcacc atctctttgg acaactccaa gaacacgctg      300

tacttgcaga tgaactccct tcgagccgag gacaccgccg tgtactactg tgctgcagct      360

cccgggtgcc tgctgagcgc gctgcggagc gcggactacc ggaactgggg ccagggtact      420

ctggtgacag tatcttctgg cggtggcggc tcccaggtcc agctccagga gagtgggccc      480

gggctggtta agccctctca gaccctgagc ctcacctgca ctgtctctgg tgcttctatc      540

accacaggcg agttctattg gaactggttc cgccagcccc cgggaaaggg ccttgaatgg      600

atgggcgcca tcgcggcatc gggctccacc acctactccc catccttcga gagccgcacc      660

agcatctcgc gcgacaccag caagaaccag ttctctctga agctgtcctc cgtaacggcc      720

gcggacaccg ccgtgtatta ctgcgggcgc tcgtttggtg tggcggccgt cacgaccggc      780

cagaaccgcg gacagggcac cctggtgacc gtcagctcgg ggggcggtgg ttctcaaatt      840

cagctggtgg agagcggcgg cggattggtg cagccaggag gctccctccg tctttcgtgt      900

gcggcttccg gcttcacgtt cagcaactac cctatgacct ggctccgcca ggcccccggc      960

aagggtctgg agtccgtgtc cgacatcacc tccggcggtg ataggcccta ttacgcggac     1020

agcgtcaagg gaaggtttac catttctcgt gacaatgcca aaaacatgct ctacctgcag     1080

atgaactccc tgcgcgccga agatactgca gtgtactact gtgccacctg ggaccgcact     1140

ctgaccggtc aaggcaccct tgtcaccgtg tcgtccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  274
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-433 CAR (nucleic acid)

<400>  274
atggcgctcc cagtgaccgc cctgcttctg cccctggccc tgctgctgca cgccgcccgc       60

cctcaggtgc agctgcagga gtctggaccc ggtctcgtca agccctctca gactctgtcc      120

ctgacctgca ctgtatccgg cgcgagcatc accacaggcg agttctattg gaattggttc      180

cgccagccac ccggcaaggg cttagagtgg atgggcgcca tcgcggcttc tggctccacg      240

acctactccc cgtccttcga gagccgcacc tccatctccc gcgataccag caagaaccag      300

ttcagcctga agctgagctc cgtcactgct gcggacaccg cggtgtatta ctgcgggcgt      360

tcctttgggg tggctgccgt caccaccggt cagaaccgcg gacagggcac cctggtaacg      420

gtgtcctcgg gtggtggagg ctcccaggtg cagttggtgg agagtggcgg tggcctggtg      480

cagcctggag gctccctacg gctttcatgc gctgcttccg gcaacatcaa ctcccgcaac      540

tgcatggggt ggttcagaca ggcccctggc aaaggcaggg agggcgtggc ggccattgga      600

caggtcaccg gccgcagcta ctacgtggat tctgtgaagg gcaggtttac catttcgttg      660

gataactcca agaacacgct ttacctccag atgaacagcc ttcgggccga agacaccgca      720

gtgtactact gtgctgcagc tcctgggtgc ctgctctccg cgctgcgctc ggcggactac      780

aggaactggg gccagggtac cctggtgacc gtctcttcgg gcgggggcgg ttcccaaatt      840

cagctgctgg agagcggggg aggactggtg cagccgggtg gatctctgcg cctgtcatgc      900

gccgcctctg gcttcacgtt cagcaactac ccgatgacct ggatccgcca ggcccccggg      960

aagggtctgg agagcgtcag tgacatcact tctggtgggg acaggcccta ttacgcggac     1020

tccgtgaaag ggcgcttcac catctctcgc gacaacgcca agaatatgct gtacctgcag     1080

atgaactccc tgcgcgccga ggacaccgcc gtgtactact gtgccacctg ggaccgcact     1140

ctttggggcc agggcaccat ggtgaccgtg tcaagcacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  275
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-467 CAR (nucleic acid)

<400>  275
atggcgcttc cggtgactgc gctgctgctg cccctggccc tccttctcca cgccgctcgc       60

cctcaggtgc agctacagga gagcggccct ggtttggtga agccctctca gacgctgtct      120

ctcacctgca ccgtgtccgg tgcttccatc accaccggcg agttctattg gaattggttc      180

agacagccac ccggcaaggg actggagtgg atgggcgcca tcgcggcatc cggctccacg      240

acctactccc cgtccttcga gagccgaacc agcatctccc gcgacacctc caaaaaccag      300

ttcagcctga agctgtcctc tgtcacggcc gcggacactg ccgtgtacta ctgcgggcgc      360

tccttcggcg tcgcagccgt caccacagga cagaaccgcg gccaaggaac tctggtgacc      420

gtctcttctg gcggaggcgg ctcccaagtg cagctggtgg agagcggtgg agggctagtt      480

cagcctggcg gttccctgcg tctatcatgc gccgccagcg gcaacattaa cagccgcaac      540

tgcatggggt ggttccgcca ggccccgggg aaggggaggg agggcgtggc tgccattgga      600

caggtcaccg gcagaagcta ctacgtggac agcgtcaagg gccgcttcac catctctctg      660

gacaactcca agaacacgct ttacctgcag atgaactcct tacgtgcgga agataccgcc      720

gtgtactact gtgcagcggc tcccgggtgc ctgctttctg ctctgcgctc cgccgattac      780

cgcaactggg gccagggcac cctggtcacg gtgagctctg gaggcggcgg gtcccagatc      840

cagctggtgg agtcgggcgg tggcttggtg cagccgggcg gctcgcttcg cctgagctgt      900

gctgcttctg gcttcacgtt cagcaactac cccatgacct ggctccgcca ggcccctggc      960

aaaggcctcg agagtgttag tgacatcact tctggcggtg atcggcccta ttacgcggac     1020

tccgtgaagg gccgcttcac catctcgcgg gacaacgcca agaatatgct gtacttgcag     1080

atgaactccc tgcgcgccga ggacaccgcc gtgtactact gtgccacctg ggaccgcacc     1140

ctgaccggtc agggaactat ggtgaccgtg tcctccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  276
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-500 CAR (nucleic acid)

<400>  276
atggccctgc cggtgactgc tctgctgctg cccctggccc tcctattaca cgccgctagg       60

cctcaggtcc agcttcagga gagcggaccc ggcctcgtca agccctctca gactctttct      120

ctgacctgca ctgtatctgg cgcttccatc accacaggcg agttctattg gaattggttc      180

agacagccgc ccggcaaagg ccttgaatgg atgggcgcca tcgcggctag cggctccacc      240

acctactccc catcctttga gagccgcacc agcatctcgc gcgacacctc caaaaaccag      300

ttcagcctga agctgagctc cgtgacggcc gcggacaccg cggtgtacta ctgcgggcgc      360

tccttcggcg tggcggccgt gaccacaggc cagaaccgcg gacagggcac cctcgtcacc      420

gtctcttccg gtggtggggg ctcccaggtg cagctggtgg agtcgggcgg cggattggtg      480

cagccaggcg gctccctccg cctgtcctgt gcagcttctg gcaacattaa ctcccgcaac      540

tgcatggggt ggttccgcca ggcccctggc aagggccgcg agggcgtcgc ggctatcggt      600

caggtcactg gaagaagcta ctacgtggat tctgtgaagg gccgtttcac catctcactg      660

gacaactcca agaacacgct ttacctgcag atgaactccc tacgcgccga ggacaccgcc      720

gtctattact gtgctgctgc tcccgggtgc ctgctgagtg cgctgcgctc cgcggactac      780

aggaactggg gccagggcac cctggtgacc gtgtcctctg gaggaggcgg gtcccaaatt      840

cagctggtgg agagtggggg tggcttggtg cagccgggcg gctccctgcg tctgtcatgc      900

gccgcctcgg gcttcacgtt cagcaactac cctatgacct ggctccgaca ggccccgggg      960

aaggggctgg agagcgtgtc cgacatcact tccggagggg acaggcccta ttacgcggac     1020

agcgttaagg gacgcttcac catctctcgg gataacgcca agaacatgct gtacctccag     1080

atgaacagcc ttcgagcaga agataccgca gtgtactact gtgccacctg ggaccgcact     1140

ctgacgggac agggtaccct ggttaccgtg tcgtcgacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  277
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-600 CAR (nucleic acid)

<400>  277
atggcgctgc ccgtgacggc cctcttgtta cccctggccc tgctgctgca cgccgccagg       60

cctcaggtgc agctgcagga gagcggccct ggtctcgtca agccctctca gactctttcg      120

ctgacctgca ccgtgtccgg cgcgtctatc accacaggcg agttctattg gaattggttc      180

agacagccgc cgggtaaggg cttggaatgg atgggggcca tcgcggcttc tggatcgacc      240

acctactccc cgtccttcga gagccgcacc tccatctctc gggacaccag caaaaaccag      300

ttttcactga agctgtcctc cgtgactgcc gcggacaccg ccgtgtacta ctgcgggcgc      360

tcgtttgggg tggcggccgt gacgaccggc cagaaccgcg gccagggaac tctggtgaca      420

gtgtcctctg ggggcggagg ctcccaggtc caattggtgg agagcggcgg cggtgtggtg      480

cagccaggcc gttctctgcg cctgtcttgt gctgcatccg gcaacattaa ctcccgcaac      540

tgcatgggct ggttccgcca ggccccgggc aaaggtcggg agggcgtggc tgcaatcggt      600

caggtcaccg gtcgcagcta ctacgtggac agtgtaaagg gccgcttcac catttctctg      660

gacaactcca agaacacgct gtacctccag atgaacagcc tccgcgccga ggacactgct      720

gtatattact gtgctgctgc tcccgggtgc ctgctctccg cgctccgcag tgcggactac      780

aggaactggg gacagggcac cctcgtcacc gtctcgtccg gagggggtgg ctcccaaatt      840

cagctgctgg agagtggtgg tgggctggtg cagccaggcg gctcccttag actttcatgc      900

gccgcttccg gcttcacgtt cagcaactac cccatgacct ggatccgcca ggcccctggc      960

aagggtctgg agagcgtttc cgacatcact tccggcgggg acaggcccta ttacgcggat     1020

tctgtgaagg gccgcttcac catctcgcgc gacaacgcca agaacatgct ttacctgcag     1080

atgaactccc tgcgcgcaga agataccgca gtgtactact gtgccacctg ggatcgaacc     1140

ctttggggcc agggcactat ggtgaccgtg tcttctacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  278
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-633 CAR (nucleic acid)

<400>  278
atggcgctgc cggtgactgc gctgctgctg cccctggccc tgctcctcca cgccgctcgc       60

cctcaggtgc agttgcagga gagtgggccc gggctggtta agccctcaca gactctgagc      120

ctgacctgca ctgtttccgg tgctagcatc actacgggcg agttctattg gaactggttc      180

agacagccac ccggcaaggg tctcgagtgg atgggggcta tcgcggcttc cggctcgacc      240

acatactccc cctctttcga gagccgcacc tctatctctc gcgataccag caaaaaccag      300

ttttcactga agctgtcctc cgtcactgct gctgacaccg cggtgtacta ctgcgggcgt      360

tccttcggcg tggcggctgt caccaccgga cagaaccgcg gacagggcac ccttgttacc      420

gtgtcgtcgg gaggaggcgg ctcccaggtc cagctggtgg agagcggggg tggggtggtg      480

cagccgggcc gttcacttcg cctgagttgt gctgcctctg gcaacatcaa ctcccgcaac      540

tgcatgggct ggttccgcca ggcccctggc aaaggccgcg agggcgtggc tgccatcggt      600

caggtcaccg gccgcagcta ctacgtggat tctgtcaagg gtaggtttac catttctctg      660

gacaactcca agaacacgct gtacctccag atgaactcct tacgtgccga ggacaccgct      720

gtctactatt gtgctgcagc cccggggtgc ctgctgtccg ctttaagaag cgcggactac      780

aggaactggg gccagggaac cctggtgact gtgagctccg gaggcggtgg atcccaaatt      840

cagctggtgg agtctggcgg cggccttgtg cagcctggtg gctccctccg tctgtcatgc      900

gccgcgtcgg gcttcacgtt cagcaactac ccgatgacct ggctccgcca ggcccccggg      960

aagggcctgg agagcgtgtc cgacatcacc tccggcgggg acaggcccta ttacgcggac     1020

tccgtgaagg gacgcttcac catctcgcgg gacaatgcca agaatatgct ttacctgcag     1080

atgaactctc tgcgcgccga agatacggcc gtgtactact gtgccacctg ggaccgcacc     1140

ctcaccggcc agggcactat ggtgacagta tcttctacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  279
<211>  1854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huAIO-667 CAR (nucleic acid)

<400>  279
atggccctgc ctgtgactgc gctcctgctg cccctggccc tgcttttgca cgccgctcgt       60

cctcaggtgc agttgcagga gagcgggccc gggctggtaa agcccagcca gactctgtcc      120

ttgacctgca ctgtatctgg tgcttccatc acgaccggcg agttctattg gaactggttc      180

cgccagccac ccggcaaggg ccttgaatgg atgggcgcca tcgcggcttc tggctcgacc      240

acctactccc cctcttttga gagccgcacc agcatctccc gggacacctc caaaaaccag      300

ttctcgctga agctgagttc cgtgacggcc gcggacactg ccgtgtacta ctgcgggcgc      360

tccttcggcg tcgcagccgt caccacagga cagaaccgcg gacagggaac tctggttacg      420

gtaagctcgg gaggcggtgg ctcccaggtc cagctggtgg agagcggagg tggtgtggtg      480

cagccgggac gcagccttcg cctttcgtgt gctgcgtccg gcaacattaa ttcccgcaac      540

tgcatgggct ggttcagaca ggccccagga aaaggcaggg agggcgtggc tgccatcggt      600

caggtcactg gccggagcta ctacgtggat tctgtgaagg gtagattcac catctctctg      660

gacaactcca agaacacgct ttacctgcag atgaactccc tgcgcgccga agataccgcc      720

gtgtactact gtgcggcggc ccctgggtgc ctgctctcgg cgctgcgctc tgcggactac      780

aggaactggg gccaggggac ccttgtcacc gtctcttctg gcggaggcgg ctcccaaatt      840

cagctggtgg agagtggggg cggcctagtg cagccgggcg gctccctgcg cctgtcatgc      900

gccgcttcgg gcttcacgtt ctcgaactac ccgatgacct ggctccgcca ggccccgggc      960

aaaggtctgg agtccgtgtc cgacatcacc agtgggggtg ataggcccta ttacgcggac     1020

agtgtcaagg gccgcttcac catctcgcgc gacaacgcca agaatatgct gtacctccag     1080

atgaactcct tacgggccga ggacacagcg gtgtactact gtgccacctg ggacaggacc     1140

ctgaccggcc agggcaccct ggtgaccgtg agctccacta gtaccacgac gccagcgccg     1200

cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg     1260

tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc     1320

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc     1380

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1440

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1500

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1560

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1620

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1680

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1740

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1800

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1854


<210>  280
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 scFv

<400>  280

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  281
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leu16 scFv

<400>  281

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp Val Lys Gln 
145                 150                 155                 160 


Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn 
                165                 170                 175     


Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            180                 185                 190         


Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Asp Tyr Tyr Cys Ala Arg Ser Asn Tyr Tyr Gly 
    210                 215                 220                 


Ser Ser Tyr Trp Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  282
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m971 scFv

<400>  282

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  283
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-623

<400>  283

Gly Arg Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  284
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-623

<400>  284

Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ala Val Arg 
1               5                   10                  15      


Gly 
    


<210>  285
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-623

<400>  285

Gly Ile Tyr Tyr Gly Ser Asn Trp Ser Ser Glu Asn 
1               5                   10          


<210>  286
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-623

<400>  286

Gly Arg Thr Phe Ser Asn Tyr Ala Ala Gly 
1               5                   10  


<210>  287
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-623

<400>  287

Ile Ser Trp Ser Gly Gly Ser Pro 
1               5               


<210>  288
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-623

<400>  288

Ala Ala Gly Ile Tyr Tyr Gly Ser Asn Trp Ser Ser Glu Asn 
1               5                   10                  


<210>  289
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-640

<400>  289

Gly Tyr Thr Trp Gln Thr Tyr Cys Met Ala 
1               5                   10  


<210>  290
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-640

<400>  290

Val Ala Thr Gly Ser Arg Thr Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  291
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-640

<400>  291

Asp Pro Arg Arg Tyr Gly Ser Cys Pro Leu Ser Ala Ala Asn Phe Asn 
1               5                   10                  15      


Asn 
    


<210>  292
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-640

<400>  292

Gly Tyr Thr Trp Gln Thr Tyr Cys 
1               5               


<210>  293
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-640

<400>  293

Val Ala Thr Gly Ser Arg Thr Thr 
1               5               


<210>  294
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-640

<400>  294

Ala Ala Asp Pro Arg Arg Tyr Gly Ser Cys Pro Leu Ser Ala Ala Asn 
1               5                   10                  15      


Phe Asn Asn 
            


<210>  295
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat) of VHH-657

<400>  295

Ala Asn Ile Arg Val Phe Tyr Leu Met Gly 
1               5                   10  


<210>  296
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (Kabat) of VHH-657

<400>  296

Arg Val Asn Ala Asp Gly Ile Thr Asn His Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  297
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (Kabat) of VHH-657

<400>  297

Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr 
1               5                   10  


<210>  298
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (IMGT) of VHH-657

<400>  298

Ala Asn Ile Arg Val Phe Tyr Leu 
1               5               


<210>  299
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (IMGT) of VHH-657

<400>  299

Val Asn Ala Asp Gly Ile Thr 
1               5           


<210>  300
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (IMGT) of VHH-657

<400>  300

Ala Thr Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr 
1               5                   10          


<210>  301
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-623 (amino acid)

<400>  301

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Pro Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Tyr Tyr Gly Ser Asn Trp Ser Ser Glu Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  302
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-640 (amino acid)

<400>  302

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Trp Gln Thr Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ala Thr Gly Ser Arg Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Tyr Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Pro Arg Arg Tyr Gly Ser Cys Pro Leu Ser Ala Ala Asn Phe 
            100                 105                 110         


Asn Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  303
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-657 (amino acid)

<400>  303

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Ala Ser Ala Asn Ile Arg Val Phe Tyr 
            20                  25                  30          


Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Glu Val 
        35                  40                  45              


Ala Arg Val Asn Ala Asp Gly Ile Thr Asn His Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Glu Asp Ser Pro Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Gly Arg Thr Trp Asn Ser Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  304
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-623 (nucleic acid)

<400>  304
caggtaaagc tggaggagag cggaggtggt ctggtgcaag ccggcggctc cctccgtctt       60

tcatgcgccg cttccggacg aacattttca aattatgcgg ctgggtggtt ccgccaggcc      120

ccgggcaagg agcgcgagtt cgtcgcagcc attagctggt ctggtggctc cccctattac      180

gcggacgccg tgcgcgggcg cttcaccatc tctcgggaca acgcgaaaaa cacggtgtac      240

ctgcagatga actccctgaa gccagaagat accgccgttt actactgtgc tgcaggcatc      300

tactacggca gcaactggtc ttcggagaac tggggccagg gcacccaggt caccgtgtcg      360

tcc                                                                    363


<210>  305
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-640 (nucleic acid)

<400>  305
caggtgaagc tggtggagag cggagggggt tccgtgcagg ccggcggatc gctgcggttg       60

tcctgtgccg cttctggcta cacctggcaa acgtactgca tggcttggtt ccgccaggct      120

cccgggaagg agagggaggg cgtagctgtg gcgactggtt cccgcaccac aagctacgcg      180

gacagtgtta aaggccgttt taccatctcc aaggactatg ccaagaatac tctgtacctg      240

cagatgtctt ctctggagcc tgaagatacc gccatgtatt actgtgctgc ggacccgcgc      300

cgctacggct catgcccact cagcgcagcc aacttcaaca actggggcca gggcacccag      360

gtcaccgtgt cctcg                                                       375


<210>  306
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-657 (nucleic acid)

<400>  306
caggtgcagc tggtggagag cggagggggc tccgctcagg ccggaggctc gctgcgccta       60

tcatgccagg cctccgccaa cattcgagtg ttctacttga tgggctggtt ccgccaggcg      120

ccggggaagg agagggagga ggtggctcgc gtcaacgcgg acggcatcac caaccatgca      180

gcctccgtaa agggccgctt caccatctct gaggacagtc caaaaaacac tctttatctg      240

cagatggatt ctctgaagcc tgaagacacc gccgtgtact actgtgccac gggtcggacc      300

tggaactccg gttttgagta ctggggccag ggcacccagg tcactgtgag ctcg            354


<210>  307
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of VHH-131 (Kabat)

<400>  307

Gly Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  308
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-131 (amino acid)

<400>  308

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Asn Ile Asn Ser Arg Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Gly Ile Gly Gln Val Thr Gly Arg Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Pro Gly Cys Leu Leu Ser Ala Leu Arg Ser Ala Asp Tyr 
            100                 105                 110         


Arg Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  309
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH-131 (nucleic acid)

<400>  309
caggtgcagc tggtggagag cggaggaggc tccgtgcagg ccggcggctc cctgcgcctg       60

tcatgcgggg cttccggcaa cattaactcc cgcaactgca tgggctggtt ccgccaggcc      120

cccggcaagg agcgcgaggg cgtggctggc atcggtcagg tcaccggccg cagctactac      180

gcggacagcg tgaagggccg cttcaccatc tctctggaca acgccaagaa catgctgtac      240

ctgcagatga acacgctgaa gcctgaagac accgccatgt attactgtgc cgcggctccc      300

gggtgcctgc tgagcgcgct ccgtagtgcg gactacagga attggggcca gggcacccag      360

gtcaccgtgt cgtcc                                                       375


<210>  310
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat with 5aa) of VHH-273,VHH-283, huVHH-253, huVHH-256

<400>  310

Ser Tyr Asn Met Gly 
1               5   


<210>  311
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat with 5aa) of VHH-313 and huVHH-260

<400>  311

Ser Tyr Ser Met Gly 
1               5   


<210>  312
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat with 5aa) of VHH-440, VHH-653, VHH-466, huVHH-836, 
       huVHH-840, huVHH-843, huVHH-846 and VHH-657

<400>  312

Phe Tyr Leu Met Gly 
1               5   


<210>  313
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat with 5aa) of VHH-496, huVHH-746, and huVHH-750, 
       huVHH-753

<400>  313

Asn Tyr Pro Met Thr 
1               5   


<210>  314
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat with 5aa) of VHH-623

<400>  314

Asn Tyr Ala Ala Gly 
1               5   


<210>  315
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (Kabat with 5aa) of VHH-640

<400>  315

Thr Tyr Cys Met Ala 
1               5   


<210>  316
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-083 & VHH-131 (Kabat with 5aa)

<400>  316

Arg Asn Cys Met Gly 
1               5   


<210>  317
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of VHH-111 (Kabat with 5aa)

<400>  317

Asn Lys Trp Met Gly 
1               5   


<210>  318
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-18 CDR1 (Kabat with 5aa)

<400>  318

Ser Val Ser Met Gly 
1               5   


<210>  319
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-66 CDR1 (Kabat with 31-35)

<400>  319

Thr Gly Glu Phe Tyr Trp Asn 
1               5           


<210>  320
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-87 CDR1 (Kabat with 5aa)

<400>  320

Thr Tyr Cys Met Gly 
1               5   


<210>  321
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-90 CDR1 (Kabat with 5aa)

<400>  321

Arg Tyr Cys Met Gly 
1               5   


<210>  322
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-102 CDR1 (Kabat with 5aa)

<400>  322

Gly Tyr Cys Leu Ala 
1               5   


<210>  323
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-105 CDR1 (Kabat with 31-35)

<400>  323

Val Ser Ile Ala 
1               


