                         SEQUENCE LISTING

<110>  Kbenhavns Universitet
       Hvidovre Hospital
       Technische Hochschule Mittelhessen, Institute fr 
       Bioverfahrenstechnik und Pharmazeutische Technologie (IBPT)
 
<120>  Method of purifying whole virus particles

<130>  70756PC01

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  3011
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Thr His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Ser Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  2
<211>  9599
<212>  DNA
<213>  Hepatitis C virus

<400>  2
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

cccatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg tcttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  3
<211>  3030
<212>  PRT
<213>  Hepatitis C virus

<400>  3

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Gln Pro Thr Gly Arg Ser Trp Gly Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Ala Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Trp Lys Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Gly Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Ile Leu Ala Leu Leu Ser Cys Leu Thr Ala Pro Thr Ser Ala Val 
            180                 185                 190         


Pro Tyr Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Glu Asp Leu Ile Leu His Ala Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Gln Gly Asn Leu Ser Arg Cys Trp Val 
225                 230                 235                 240 


Gln Ile Thr Pro Thr Leu Ser Ala Pro Ser Leu Gly Ala Val Thr Ala 
                245                 250                 255     


Pro Leu Arg Arg Ala Val Asp Tyr Leu Ala Gly Gly Ala Ala Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Ala Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Met Phe Thr Tyr Ser Pro Arg Arg His Asn Val Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Ser Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Met Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Val Val Ile Asp Ile Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Phe Ala Ala Ala Tyr Tyr Ala Ser Ala Ala Asn Trp 
        355                 360                 365             


Ala Lys Val Val Leu Val Leu Phe Leu Phe Ala Gly Val Asp Ala Ser 
    370                 375                 380                 


Pro Arg Thr Val Gly Gly Ser Ala Ala Gln Gly Ala Arg Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Thr Pro Gly Pro Gln Gln Asn Leu Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Val Ala Gly Leu Leu Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Met Ala Ser Cys Arg Pro Leu Ala Ala 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Thr Ile Ser Tyr Ala Ala Val Ser Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Lys Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Arg Gly Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Arg Lys Gly Asn Pro Thr Tyr 
        515                 520                 525             


Ser Trp Gly Glu Asn Glu Thr Asp Ile Phe Leu Leu Asn Asn Thr Arg 
    530                 535                 540                 


Pro Pro Thr Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Val Lys Thr Cys Gly Ala Pro Pro Cys Asn Leu Gly Pro Thr Gly 
                565                 570                 575     


Asn Asn Ser Leu Lys Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp 
            580                 585                 590         


Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
        595                 600                 605             


Leu Val His Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Leu Asn 
    610                 615                 620                 


Tyr Thr Ile Phe Lys Val Arg Met Tyr Ile Gly Gly Leu Glu His Arg 
625                 630                 635                 640 


Leu Glu Val Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
                645                 650                 655     


Asp Arg Asp Arg Ala Glu Leu Ser Pro Leu Leu His Thr Thr Thr Gln 
            660                 665                 670         


Trp Ala Ile Leu Pro Cys Ser Phe Thr Pro Thr Pro Ala Leu Ser Thr 
        675                 680                 685             


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Thr Gln Tyr Leu Tyr 
    690                 695                 700                 


Gly Leu Ser Ser Ser Ile Val Ser Trp Ala Val Lys Trp Glu Tyr Ile 
705                 710                 715                 720 


Val Leu Ala Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys Thr Cys Leu 
                725                 730                 735     


Trp Ile Met Leu Leu Val Cys Gln Ala Glu Ala Ala Leu Glu Asn Val 
            740                 745                 750         


Ile Val Leu Asn Ala Ala Ala Ala Ala Gly Thr His Gly Phe Phe Trp 
        755                 760                 765             


Gly Leu Leu Val Ile Cys Phe Ala Trp His Phe Lys Gly Arg Val Val 
    770                 775                 780                 


Pro Gly Ala Thr Tyr Leu Cys Leu Gly Ile Trp Pro Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Phe Leu Leu Pro Gln Arg Ala Leu Ala Leu Asp Ser Ser Asp Gly 
                805                 810                 815     


Gly Thr Val Gly Cys Leu Val Leu Thr Ile Leu Thr Ile Phe Thr Leu 
            820                 825                 830         


Thr Pro Gly Tyr Lys Lys Met Val Val Leu Val Ile Trp Trp Leu Gln 
        835                 840                 845             


Tyr Phe Ile Ala Arg Val Glu Ala Phe Ile His Val Trp Val Pro Pro 
    850                 855                 860                 


Leu Gln Val Arg Gly Gly Arg Asp Ala Ile Ile Met Leu Thr Cys Leu 
865                 870                 875                 880 


Phe His Pro Ala Leu Gly Phe Glu Val Thr Lys Ile Leu Leu Gly Ile 
                885                 890                 895     


Leu Gly Pro Leu Cys Leu Leu Gln Tyr Ser Leu Ile Lys Leu Pro Tyr 
            900                 905                 910         


Phe Ile Arg Ala Arg Ala Leu Leu Arg Ala Cys Leu Leu Ala Lys His 
        915                 920                 925             


Leu Ala Cys Gly Arg Tyr Val Gln Ala Ala Leu Leu His Leu Gly Arg 
    930                 935                 940                 


Leu Thr Gly Thr Tyr Ile Tyr Asp His Leu Ala Pro Met Lys Asp Trp 
945                 950                 955                 960 


Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Thr Glu Pro Ile Ile 
                965                 970                 975     


Phe Ser Pro Met Glu Thr Lys Val Ile Thr Trp Gly Ala Asp Thr Ala 
            980                 985                 990         


Ala Cys Gly Asp Ile Leu Ala Gly  Leu Pro Val Ser Ala  Arg Arg Gly 
        995                 1000                 1005             


His Glu  Ile Phe Leu Gly Pro  Ala Asp Asp Ile Arg  Glu Gly Gly 
    1010                 1015                 1020             


Trp Arg  Leu Leu Ala Pro Ile  Thr Ala Tyr Ala Gln  Gln Thr Arg 
    1025                 1030                 1035             


Gly Leu  Leu Gly Ala Ile Val  Val Ser Met Thr Gly  Arg Asp Arg 
    1040                 1045                 1050             


Thr Glu  Gln Ala Gly Glu Val  Gln Ile Leu Ser Thr  Val Ser Gln 
    1055                 1060                 1065             


Ser Phe  Leu Gly Thr Thr Ile  Ser Gly Val Leu Trp  Thr Val Tyr 
    1070                 1075                 1080             


His Gly  Ala Gly Asn Lys Thr  Leu Ala Gly Leu Arg  Gly Pro Val 
    1085                 1090                 1095             


Thr Gln  Met Tyr Ser Ser Ala  Glu Gly Asp Leu Val  Gly Trp Pro 
    1100                 1105                 1110             


Ser Pro  Pro Gly Thr Arg Ser  Leu Glu Pro Cys Lys  Cys Gly Ala 
    1115                 1120                 1125             


Val Asp  Leu Tyr Leu Val Thr  Arg Asn Ala Asp Val  Ile Pro Ala 
    1130                 1135                 1140             


Arg Arg  Arg Gly Asp Lys Arg  Gly Ala Leu Leu Ser  Pro Arg Pro 
    1145                 1150                 1155             


Ile Ser  Thr Leu Lys Gly Ser  Ser Gly Gly Pro Val  Leu Cys Pro 
    1160                 1165                 1170             


Arg Gly  His Val Val Gly Leu  Phe Arg Ala Ala Val  Cys Ser Arg 
    1175                 1180                 1185             


Gly Val  Ala Lys Ser Ile Asp  Phe Ile Pro Val Glu  Thr Leu Asp 
    1190                 1195                 1200             


Val Val  Thr Arg Ser Pro Thr  Phe Ser Asp Asn Ser  Thr Pro Pro 
    1205                 1210                 1215             


Ala Val  Pro Gln Thr Tyr Gln  Val Gly Tyr Leu His  Ala Pro Thr 
    1220                 1225                 1230             


Gly Ser  Gly Lys Ser Thr Lys  Val Pro Val Ala Tyr  Ala Ala Gln 
    1235                 1240                 1245             


Gly Tyr  Lys Val Leu Val Leu  Asn Pro Ser Val Ala  Ala Thr Leu 
    1250                 1255                 1260             


Gly Phe  Gly Ala Tyr Leu Ser  Lys Ala His Gly Ile  Asn Pro Asn 
    1265                 1270                 1275             


Ile Arg  Thr Gly Val Arg Thr  Val Met Thr Gly Glu  Ala Ile Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Tyr Gly Lys Phe  Leu Ala Asp Gly Gly  Cys Ala Ser 
    1295                 1300                 1305             


Gly Ala  Tyr Asp Ile Ile Ile  Cys Asp Glu Cys His  Ala Val Asp 
    1310                 1315                 1320             


Ala Thr  Ser Ile Leu Gly Ile  Gly Thr Val Leu Asp  Gln Ala Glu 
    1325                 1330                 1335             


Thr Ala  Gly Val Arg Leu Thr  Val Leu Ala Thr Ala  Thr Pro Pro 
    1340                 1345                 1350             


Gly Ser  Val Thr Thr Pro His  Pro Asp Ile Glu Glu  Val Gly Leu 
    1355                 1360                 1365             


Gly Arg  Glu Gly Glu Ile Pro  Phe Tyr Gly Arg Ala  Ile Pro Leu 
    1370                 1375                 1380             


Ser Cys  Ile Lys Gly Gly Arg  His Leu Ile Phe Cys  His Ser Lys 
    1385                 1390                 1395             


Lys Lys  Cys Asp Glu Leu Ala  Ala Ala Leu Arg Gly  Met Gly Leu 
    1400                 1405                 1410             


Asn Ala  Val Ala Tyr Tyr Arg  Gly Leu Asp Val Ser  Ile Ile Pro 
    1415                 1420                 1425             


Ala Gln  Gly Asp Val Val Val  Val Ala Thr Asp Ala  Leu Met Thr 
    1430                 1435                 1440             


Gly Tyr  Thr Gly Asp Phe Asp  Ser Val Ile Asp Cys  Asn Val Ala 
    1445                 1450                 1455             


Val Thr  Gln Ala Val Asp Phe  Ser Leu Asp Pro Thr  Phe Thr Ile 
    1460                 1465                 1470             


Thr Thr  Gln Thr Val Pro Gln  Asp Ala Val Ser Arg  Ser Gln Arg 
    1475                 1480                 1485             


Arg Gly  Arg Thr Gly Arg Gly  Arg Gln Gly Thr Tyr  Arg Tyr Val 
    1490                 1495                 1500             


Ser Thr  Gly Glu Arg Ala Ser  Gly Met Phe Asp Ser  Val Val Leu 
    1505                 1510                 1515             


Cys Glu  Cys Tyr Asp Ala Gly  Ala Ala Trp Tyr Asp  Leu Thr Pro 
    1520                 1525                 1530             


Ala Glu  Thr Thr Val Arg Leu  Arg Ala Tyr Phe Asn  Thr Pro Gly 
    1535                 1540                 1545             


Leu Pro  Val Cys Gln Asp His  Leu Glu Phe Trp Glu  Ala Val Phe 
    1550                 1555                 1560             


Thr Gly  Leu Thr His Ile Asp  Ala His Phe Leu Ser  Gln Thr Lys 
    1565                 1570                 1575             


Gln Ala  Gly Glu Asn Phe Ala  Tyr Leu Val Ala Tyr  Gln Ala Thr 
    1580                 1585                 1590             


Val Cys  Ala Arg Ala Lys Ala  Pro Pro Pro Ser Trp  Asp Ala Met 
    1595                 1600                 1605             


Trp Lys  Cys Leu Ala Arg Leu  Lys Pro Thr Leu Ala  Gly Pro Thr 
    1610                 1615                 1620             


Pro Leu  Leu Tyr Arg Leu Gly  Pro Ile Thr Asn Glu  Val Thr Leu 
    1625                 1630                 1635             


Thr His  Pro Gly Thr Lys Tyr  Ile Ala Thr Cys Met  Gln Ala Asp 
    1640                 1645                 1650             


Leu Glu  Val Met Thr Ser Thr  Trp Val Leu Ala Gly  Gly Val Leu 
    1655                 1660                 1665             


Ala Ala  Val Ala Ala Tyr Cys  Leu Ala Thr Gly Cys  Val Ser Ile 
    1670                 1675                 1680             


Ile Gly  Arg Leu His Val Asn  Gln Arg Val Val Val  Ala Pro Asp 
    1685                 1690                 1695             


Lys Glu  Val Leu Tyr Glu Ala  Phe Asp Glu Met Glu  Glu Cys Ala 
    1700                 1705                 1710             


Ser Arg  Ala Ala Leu Ile Glu  Glu Gly Gln Arg Ile  Ala Glu Met 
    1715                 1720                 1725             


Leu Lys  Ser Lys Ile Gln Gly  Leu Leu Gln Gln Ala  Ser Lys Gln 
    1730                 1735                 1740             


Ala Gln  Asp Ile Gln Pro Ala  Met Gln Ala Ser Trp  Pro Lys Val 
    1745                 1750                 1755             


Glu Gln  Phe Trp Ala Arg His  Met Trp Asn Phe Ile  Ser Gly Ile 
    1760                 1765                 1770             


Gln Tyr  Leu Ala Gly Leu Ser  Thr Leu Pro Gly Asn  Pro Ala Val 
    1775                 1780                 1785             


Ala Ser  Met Met Ala Phe Ser  Ala Ala Leu Thr Ser  Pro Leu Ser 
    1790                 1795                 1800             


Thr Ser  Thr Thr Ile Leu Leu  Asn Ile Met Gly Gly  Trp Leu Ala 
    1805                 1810                 1815             


Ser Gln  Ile Ala Pro Pro Ala  Gly Ala Thr Gly Phe  Val Val Ser 
    1820                 1825                 1830             


Gly Leu  Val Gly Ala Ala Val  Gly Ser Ile Gly Leu  Gly Lys Val 
    1835                 1840                 1845             


Leu Val  Asp Ile Leu Ala Gly  Tyr Gly Ala Gly Ile  Ser Gly Ala 
    1850                 1855                 1860             


Leu Val  Ala Phe Lys Ile Met  Ser Gly Glu Lys Pro  Ser Met Glu 
    1865                 1870                 1875             


Asp Val  Ile Asn Leu Leu Pro  Gly Ile Leu Ser Pro  Gly Ala Leu 
    1880                 1885                 1890             


Val Val  Gly Val Ile Cys Ala  Ala Ile Leu Arg Arg  His Val Gly 
    1895                 1900                 1905             


Pro Gly  Glu Gly Ala Val Gln  Trp Met Asn Arg Leu  Ile Ala Phe 
    1910                 1915                 1920             


Ala Ser  Arg Gly Asn His Val  Ala Pro Thr His Tyr  Val Thr Glu 
    1925                 1930                 1935             


Ser Asp  Ala Ser Gln Arg Val  Thr Gln Leu Leu Gly  Ser Leu Thr 
    1940                 1945                 1950             


Ile Thr  Ser Leu Leu Arg Arg  Leu His Asn Trp Ile  Thr Glu Asp 
    1955                 1960                 1965             


Cys Pro  Ile Pro Cys Ser Gly  Ser Trp Leu Arg Asp  Val Trp Asp 
    1970                 1975                 1980             


Trp Val  Cys Thr Ile Leu Thr  Asp Phe Lys Asn Trp  Leu Thr Ser 
    1985                 1990                 1995             


Lys Leu  Phe Pro Lys Leu Pro  Gly Leu Pro Phe Ile  Ser Cys Gln 
    2000                 2005                 2010             


Lys Gly  Tyr Lys Gly Val Trp  Ala Gly Thr Gly Ile  Met Thr Thr 
    2015                 2020                 2025             


Arg Cys  Pro Cys Gly Ala Asp  Ile Ser Gly Asn Val  Arg Leu Gly 
    2030                 2035                 2040             


Ser Met  Arg Ile Thr Gly Pro  Lys Thr Cys Met Asn  Thr Trp Gln 
    2045                 2050                 2055             


Gly Thr  Phe Pro Ile Asn Cys  Tyr Thr Glu Gly Gln  Cys Ala Pro 
    2060                 2065                 2070             


Lys Pro  Pro Thr Asn Tyr Lys  Thr Ala Ile Trp Arg  Val Ala Ala 
    2075                 2080                 2085             


Ser Glu  Tyr Ala Glu Val Thr  Gln His Gly Ser Tyr  Ser Tyr Val 
    2090                 2095                 2100             


Thr Gly  Leu Thr Thr Asp Asn  Leu Lys Ile Pro Cys  Gln Leu Pro 
    2105                 2110                 2115             


Ser Pro  Glu Phe Phe Ser Trp  Val Asp Gly Val Gln  Ile His Arg 
    2120                 2125                 2130             


Phe Ala  Pro Thr Pro Lys Pro  Phe Phe Arg Asp Glu  Val Ser Phe 
    2135                 2140                 2145             


Cys Val  Gly Leu Asn Ser Tyr  Ala Val Gly Ser Gln  Leu Pro Cys 
    2150                 2155                 2160             


Glu Pro  Glu Pro Asp Ala Asp  Val Leu Arg Ser Met  Leu Thr Asp 
    2165                 2170                 2175             


Pro Pro  His Ile Thr Ala Glu  Thr Ala Ala Arg Arg  Leu Ala Arg 
    2180                 2185                 2190             


Gly Ser  Pro Pro Ser Glu Ala  Ser Ser Ser Val Ser  Gln Leu Ser 
    2195                 2200                 2205             


Ala Pro  Ser Leu Arg Ala Thr  Cys Thr Thr His Ser  Asn Thr Tyr 
    2210                 2215                 2220             


Asp Val  Asp Met Val Asp Ala  Asn Leu Leu Met Gly  Gly Gly Val 
    2225                 2230                 2235             


Ala Gln  Thr Glu Pro Glu Ser  Arg Val Pro Ala Leu  Asp Phe Leu 
    2240                 2245                 2250             


Glu Pro  Met Ala Glu Glu Glu  Ser Asp Pro Glu Pro  Ser Ile Pro 
    2255                 2260                 2265             


Ser Glu  Cys Met Leu Pro Arg  Ser Gly Phe Pro Arg  Ala Leu Pro 
    2270                 2275                 2280             


Ala Trp  Ala Arg Pro Asp Tyr  Asn Pro Pro Leu Val  Glu Ser Trp 
    2285                 2290                 2295             


Arg Arg  Pro Asp Tyr Gln Pro  Pro Thr Val Ala Gly  Cys Ala Leu 
    2300                 2305                 2310             


Pro Pro  Pro Lys Lys Ala Pro  Thr Pro Pro Pro Arg  Arg Arg Arg 
    2315                 2320                 2325             


Thr Val  Gly Leu Ser Glu Ser  Thr Thr Ser Glu Ala  Leu Gln Gln 
    2330                 2335                 2340             


Leu Ala  Ile Lys Thr Phe Gly  Gln Pro Pro Ser Ser  Gly Asp Ala 
    2345                 2350                 2355             


Gly Ser  Ser Thr Gly Ala Gly  Ala Ala Glu Ser Gly  Gly Pro Thr 
    2360                 2365                 2370             


Ser Pro  Gly Glu Pro Ala Pro  Ser Glu Thr Gly Ser  Ala Ser Ser 
    2375                 2380                 2385             


Met Pro  Pro Leu Glu Gly Glu  Pro Gly Asp Pro Asp  Leu Glu Ser 
    2390                 2395                 2400             


Asp Gln  Val Glu Leu Gln Pro  Pro Pro Gln Gly Gly  Gly Val Ala 
    2405                 2410                 2415             


Pro Gly  Ser Gly Ser Gly Ser  Trp Ser Thr Cys Ser  Glu Glu Asp 
    2420                 2425                 2430             


Asp Thr  Thr Val Cys Cys Ser  Met Ser Tyr Ser Trp  Thr Gly Ala 
    2435                 2440                 2445             


Leu Ile  Thr Pro Cys Ser Pro  Glu Glu Glu Lys Leu  Pro Ile Asn 
    2450                 2455                 2460             


Pro Leu  Ser Asn Ser Leu Leu  Arg Tyr His Asn Lys  Val Tyr Cys 
    2465                 2470                 2475             


Thr Thr  Ser Lys Ser Ala Ser  Gln Arg Ala Lys Lys  Val Thr Phe 
    2480                 2485                 2490             


Asp Arg  Thr Gln Val Leu Asp  Ala His Tyr Asp Ser  Val Leu Lys 
    2495                 2500                 2505             


Asp Ile  Lys Leu Ala Ala Ser  Lys Val Ser Ser Arg  Leu Leu Thr 
    2510                 2515                 2520             


Leu Glu  Glu Ala Cys Gln Leu  Thr Pro Pro His Ser  Ala Arg Ser 
    2525                 2530                 2535             


Lys Tyr  Gly Phe Gly Ala Lys  Glu Val Arg Ser Leu  Ser Gly Arg 
    2540                 2545                 2550             


Ala Val  Asn His Ile Lys Ser  Val Trp Lys Asp Leu  Leu Glu Asp 
    2555                 2560                 2565             


Pro Gln  Thr Pro Ile Pro Thr  Thr Ile Met Ala Lys  Asn Glu Val 
    2570                 2575                 2580             


Phe Cys  Val Asp Pro Ala Lys  Gly Gly Lys Lys Pro  Ala Arg Leu 
    2585                 2590                 2595             


Ile Val  Tyr Pro Asp Leu Gly  Val Arg Val Cys Glu  Lys Met Ala 
    2600                 2605                 2610             


Leu Tyr  Asp Ile Thr Gln Lys  Leu Pro Gln Ala Val  Met Gly Ala 
    2615                 2620                 2625             


Ser Tyr  Gly Phe Gln Tyr Ser  Pro Ala Gln Arg Val  Glu Tyr Leu 
    2630                 2635                 2640             


Leu Lys  Ala Trp Ala Glu Lys  Lys Asp Pro Met Gly  Phe Ser Tyr 
    2645                 2650                 2655             


Asp Thr  Arg Cys Phe Asp Ser  Thr Val Thr Glu Arg  Asp Ile Arg 
    2660                 2665                 2670             


Thr Glu  Glu Ser Ile Tyr Gln  Ala Cys Ser Leu Pro  Glu Glu Ala 
    2675                 2680                 2685             


Arg Thr  Ala Ile His Ser Leu  Thr Glu Arg Leu Tyr  Val Gly Gly 
    2690                 2695                 2700             


Pro Met  Phe Asn Ser Lys Gly  Gln Thr Cys Gly Tyr  Arg Arg Cys 
    2705                 2710                 2715             


Arg Ala  Ser Gly Val Leu Thr  Thr Ser Met Gly Asn  Thr Ile Thr 
    2720                 2725                 2730             


Cys Tyr  Val Lys Ala Leu Ala  Ala Cys Lys Ala Ala  Gly Ile Val 
    2735                 2740                 2745             


Ala Pro  Thr Met Leu Val Cys  Gly Asp Asp Leu Val  Val Ile Ser 
    2750                 2755                 2760             


Glu Ser  Gln Gly Thr Glu Glu  Asp Glu Arg Asn Leu  Arg Ala Phe 
    2765                 2770                 2775             


Thr Glu  Ala Met Thr Arg Tyr  Ser Ala Pro Pro Gly  Asp Pro Pro 
    2780                 2785                 2790             


Arg Pro  Glu Tyr Asp Leu Glu  Leu Ile Thr Ser Cys  Ser Ser Asn 
    2795                 2800                 2805             


Val Ser  Val Ala Leu Gly Pro  Arg Gly Arg Arg Arg  Tyr Tyr Leu 
    2810                 2815                 2820             


Thr Arg  Asp Pro Thr Thr Pro  Leu Ala Arg Ala Ala  Trp Glu Thr 
    2825                 2830                 2835             


Val Arg  His Ser Pro Ile Asn  Ser Trp Leu Gly Asn  Ile Ile Gln 
    2840                 2845                 2850             


Tyr Ala  Pro Thr Ile Trp Ala  Arg Met Val Leu Met  Thr His Phe 
    2855                 2860                 2865             


Phe Ser  Ile Leu Met Val Gln  Asp Thr Leu Asp Gln  Asn Leu Asn 
    2870                 2875                 2880             


Phe Glu  Met Tyr Gly Ser Val  Tyr Ser Val Asn Pro  Leu Asp Leu 
    2885                 2890                 2895             


Pro Ala  Ile Ile Glu Arg Leu  His Gly Leu Asp Ala  Phe Ser Met 
    2900                 2905                 2910             


His Thr  Tyr Ser His His Glu  Leu Thr Arg Val Ala  Ser Ala Leu 
    2915                 2920                 2925             


Arg Lys  Leu Gly Ala Pro Pro  Leu Arg Val Trp Lys  Ser Arg Ala 
    2930                 2935                 2940             


Arg Ala  Val Arg Ala Ser Leu  Ile Ser Arg Gly Gly  Lys Ala Ala 
    2945                 2950                 2955             


Val Cys  Gly Arg Tyr Leu Phe  Asn Trp Ala Val Lys  Thr Lys Leu 
    2960                 2965                 2970             


Lys Leu  Thr Pro Leu Pro Glu  Ala Arg Leu Leu Asp  Leu Ser Ser 
    2975                 2980                 2985             


Trp Phe  Thr Val Gly Ala Gly  Gly Gly Asp Ile Phe  His Ser Val 
    2990                 2995                 3000             


Ser Arg  Ala Arg Pro Arg Ser  Leu Leu Phe Gly Leu  Leu Leu Leu 
    3005                 3010                 3015             


Phe Val  Gly Val Gly Leu Phe  Leu Leu Pro Ala Arg  
    3020                 3025                 3030 


<210>  4
<211>  9669
<212>  DNA
<213>  Hepatitis C virus

<400>  4
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

cgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacga atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg ccgcccacag gacgtcaagt tcccgggcgg      420

tggtcagatc gttggtggag tttacttgtt gccgcgcagg ggccctaggt tgggtgtgcg      480

cgcaactcgg aagacttcag aacggtcgca accccgtgga cggcgtcagc ctatccccaa      540

ggcgcgccag cccacgggcc ggtcctgggg tcaacccggg tacccttggc ccctttatgc      600

caatgagggc ctcgggtggg cagggtggtt gctctccccc cgaggctctc ggcctaattg      660

gggccccaat gacccccggt ggaaatcgcg caacttgggt aaggtcatcg ataccctgac      720

gtgcggattc gccgacctca tggggtacat cccgctcgta ggcggccccg ttgggggcgt      780

cgcaagggct ctcgcacacg gtgtgagggt ccttgaggac ggggtaaact atgcaacagg      840

gaatttaccc ggttgctctt tctctatctt tatccttgca cttctttcat gcctgactgc      900

cccgacctct gccgttccct accgaaatgc ctctggggtt tatcatgtca ccaatgattg      960

cccaaactct tctatcgtct atgaggctga agacctgatc ttacacgcac ctggttgcgt     1020

gccctgtgtt aggcagggta atctcagtag gtgctgggtc cagatcaccc ccacactgtc     1080

agccccgagc ctcggagcgg tcacggctcc tcttcggagg gccgttgact acttagcggg     1140

gggggctgcc ctttgctccg cgttatacgt cggagacgcg tgcggggcag tgtttttggt     1200

aggtcaaatg ttcacctata gccctcgccg gcataatgtt gtgcaggact gcaactgttc     1260

catttacagt ggccacatca ccggccaccg gatggcatgg gacatgatga tgaattggtc     1320

acctacaaca gctttggtga tggcccagtt gttacggatt ccccaggtgg tcattgacat     1380

cattgccggg gcccactggg gggtcttgtt cgccgccgca tactacgcgt cggcggctaa     1440

ctgggccaag gttgtgctgg tcctgtttct gtttgcgggg gtcgatgcca gcccccgcac     1500

tgtgggtggt agtgcggccc aaggcgcgcg cgggctcgct tcacttttca cccctgggcc     1560

gcagcagaac ttgcagctca taaataccaa cgggagctgg cacatcaaca gaactgccct     1620

taactgtaat gacagcctcc agactgggtt tgtagccggc ctcctgtatt atcacaagtt     1680

caactccact gggtgtccgc agcggatggc tagctgtagg cccctcgccg cattcgacca     1740

gggctgggga actatcagct atgccgccgt gtcgggcccc agtgatgaca agccctattg     1800

ctggcactac cccccacgcc cgtgcggaat agtgccagcg cgaggtgtct gcggtccggt     1860

ctattgtttt acacctagcc cggtggtcgt cggcaccaca gaccgcaagg ggaatcccac     1920

ttacagttgg ggcgaaaatg agactgacat ctttctcttg aacaacacga ggccccctac     1980

tggcaactgg tttggctgca cctggatgaa ttccacaggg tttgtcaaga cttgcggggc     2040

tccaccctgc aacttagggc ctacaggcaa caatagcctt aagtgtccta ctgattgctt     2100

ccgcaagcac ccagacgcca cctacaccaa gtgtgggtca ggaccctggc tcactccccg     2160

gtgtctggtg cattaccctt accggttgtg gcattacccg tgcaccctaa attacaccat     2220

cttcaaggtg cgcatgtaca ttgggggcct cgagcacagg ctcgaggtgg catgcaactg     2280

gacccgtggt gagcggtgtg atcttgaaga cagggatagg gccgagctga gcccgctcct     2340

acataccacc acgcagtggg ccatattgcc gtgctctttc acacccacac ccgctcttag     2400

cactggtctc atacacttac atcaaaatat agtagacacc cagtatcttt acggtctgag     2460

ctccagcatc gtctcgtggg ccgttaagtg ggagtacata gtgctggcct tcttattact     2520

tgctgatgcc cgtatttgta cttgcctatg gatcatgctc ctggtttgtc aggccgaagc     2580

ggccctggag aacgtcattg tcctaaacgc ggctgcggct gcggggactc atgggttttt     2640

ctggggcctg ctcgtcatct gcttcgcctg gcacttcaag ggcagggtgg tccctggggc     2700

cacctacctt tgcttgggca tttggccatt actcttactc cttttcctcc tgccccaaag     2760

ggctctagcc ctggactcaa gcgatggcgg gactgtgggt tgtcttgtgt taaccatcct     2820

tacaatcttc acactcaccc ccgggtacaa gaagatggta gtgttggtca tatggtggct     2880

tcagtatttc atagcccggg tagaggcctt tatccatgtg tgggtgcccc cgttgcaggt     2940

taggggtggt cgtgatgcta ttatcatgct cacatgcctt ttccatcctg ccctggggtt     3000

tgaggtcacg aaaatcctcc tcgggatact aggtcctttg tgcctgctgc agtactcgct     3060

catcaagctg ccttatttca tcagggcgcg cgccctgctg agggcgtgcc tgctagcgaa     3120

gcacttggcc tgtggcaggt acgtgcaggc ggccttgctc caccttggta ggctgaccgg     3180

aacgtacatt tatgaccacc ttgcccccat gaaggattgg gcagcgtccg ggctgcgcga     3240

cttagcagtg gccacggagc ccatcatatt ctcccctatg gagacgaagg tcatcacgtg     3300

gggggctgac acggccgcat gtggggacat acttgccggc cttcctgtat cagctaggcg     3360

aggccatgaa atcttcctgg ggccagccga tgacatcaga gaggggggct ggcgacttct     3420

cgctcccatc actgcttatg cccagcaaac acgaggcctc ctgggcgcca tagtggtgag     3480

tatgacgggg cgtgacagga cagaacaggc cggggaagtc caaatcctgt ccacagtctc     3540

tcagtccttc ctcggaacaa ccatctcggg ggttttgtgg actgtttacc acggagctgg     3600

caacaagact ctagccggct tacggggtcc ggtcacgcag atgtactcga gtgctgaggg     3660

ggacttggta ggctggccca gcccccctgg gaccaggtct ttggagccgt gcaagtgtgg     3720

agccgtcgac ctatatctgg tcacgcggaa cgctgatgtc atcccggctc ggagacgcgg     3780

ggacaagcgg ggagcattgc tctccccgag acccatttcg accttgaagg ggtcctcggg     3840

ggggccggtg ctctgcccta ggggccacgt cgttgggctc ttccgagcag ctgtgtgctc     3900

tcggggcgtg gccaaatcca tcgatttcat ccccgttgag acactcgacg ttgttacaag     3960

gtctcccact ttcagtgaca acagcacgcc accggctgtg ccccagacct atcaggtcgg     4020

gtacttgcat gctccaactg gcagtggaaa gagcaccaag gtccctgtcg cgtatgccgc     4080

ccaggggtac aaagtactag tgcttaaccc ctcggtagct gccaccctgg ggtttggggc     4140

gtacctatcc aaggcacatg gcatcaatcc caacattagg actggagtca ggaccgtgat     4200

gaccggggag gccatcacgt actccacata tggcaaattt ctcgccgatg ggggctgcgc     4260

tagcggcgcc tatgacatca tcatatgcga tgaatgccac gctgtggatg ctacctccat     4320

tctcggcatc ggaacggtcc ttgatcaagc agagacagcc ggggtcagac taactgtgct     4380

ggctacggcc acaccccccg ggtcagtgac aaccccccat cccgatatag aagaggtagg     4440

cctcgggcgg gagggtgaga tccccttcta tgggagggcg attcccctat cctgcatcaa     4500

gggagggaga cacctgattt tctgccactc aaagaaaaag tgtgacgagc tcgcggcggc     4560

ccttcggggc atgggcttga atgccgtggc atactataga gggttggacg tctccataat     4620

accagctcag ggagatgtgg tggtcgtcgc caccgacgcc ctcatgacgg ggtacactgg     4680

agactttgac tccgtgatcg actgcaatgt agcggtcacc caagctgtcg acttcagcct     4740

ggaccccacc ttcactataa ccacacagac tgtcccacaa gacgctgtct cacgcagtca     4800

gcgccgcggg cgcacaggta gaggaagaca gggcacttat aggtatgttt ccactggtga     4860

acgagcctca ggaatgtttg acagtgtagt gctttgtgag tgctacgacg caggggctgc     4920

gtggtacgat ctcacaccag cggagaccac cgtcaggctt agagcgtatt tcaacacgcc     4980

cggcctaccc gtgtgtcaag accatcttga attttgggag gcagttttca ccggcctcac     5040

acacatagac gcccacttcc tctcccaaac aaagcaagcg ggggagaact tcgcgtacct     5100

agtagcctac caagctacgg tgtgcgccag agccaaggcc cctcccccgt cctgggacgc     5160

catgtggaag tgcctggccc gactcaagcc tacgcttgcg ggccccacac ctctcctgta     5220

ccgtttgggc cctattacca atgaggtcac cctcacacac cctgggacga agtacatcgc     5280

cacatgcatg caagctgacc ttgaggtcat gaccagcacg tgggtcctag ctggaggagt     5340

cctggcagcc gtcgccgcat attgcctggc gactggatgc gtttccatca tcggccgctt     5400

gcacgtcaac cagcgagtcg tcgttgcgcc ggataaggag gtcctgtatg aggcttttga     5460

tgagatggag gaatgcgcct ctagggcggc tctcatcgaa gaggggcagc ggatagccga     5520

gatgttgaag tccaagatcc aaggcttgct gcagcaggcc tctaagcagg cccaggacat     5580

acaacccgct atgcaggctt catggcccaa agtggaacaa ttttgggcca gacacatgtg     5640

gaacttcatt agcggcatcc aatacctcgc aggattgtca acactgccag ggaaccccgc     5700

ggtggcttcc atgatggcat tcagtgccgc cctcaccagt ccgttgtcga ccagtaccac     5760

catccttctc aacatcatgg gaggctggtt agcgtcccag atcgcaccac ccgcgggggc     5820

caccggcttt gtcgtcagtg gcctggtggg ggctgccgtg ggcagcatag gcctgggtaa     5880

ggtgctggtg gacatcctgg caggatatgg tgcgggcatt tcgggggccc tcgtcgcatt     5940

caagatcatg tctggcgaga agccctctat ggaagatgtc atcaatctac tgcctgggat     6000

cctgtctccg ggagccctgg tggtgggggt catctgcgcg gccattctgc gccgccacgt     6060

gggaccgggg gagggcgcgg tccaatggat gaacaggctt attgcctttg cttccagagg     6120

aaaccacgtc gcccctactc actacgtgac ggagtcggat gcgtcgcagc gtgtgaccca     6180

actacttggc tctcttacta taaccagcct actcagaaga ctccacaatt ggataactga     6240

ggactgcccc atcccatgct ccggatcctg gctccgcgac gtgtgggact gggtttgcac     6300

catcttgaca gacttcaaaa attggctgac ctctaaattg ttccccaagc tgcccggcct     6360

ccccttcatc tcttgtcaaa aggggtacaa gggtgtgtgg gccggcactg gcatcatgac     6420

cacgcgctgc ccttgcggcg ccgacatctc tggcaatgtc cgcctgggct ctatgaggat     6480

cacagggcct aaaacctgca tgaacacctg gcaggggacc tttcctatca attgctacac     6540

ggagggccag tgcgcgccga aaccccccac gaactacaag accgccatct ggagggtggc     6600

ggcctcggag tacgcggagg tgacgcagca tgggtcgtac tcctatgtaa caggactgac     6660

cactgacaat ctgaaaattc cttgccaact accttctcca gagtttttct cctgggtgga     6720

cggtgtgcag atccataggt ttgcacccac accaaagccg tttttccggg atgaggtctc     6780

gttctgcgtt gggcttaatt cctatgctgt cgggtcccag cttccctgtg aacctgagcc     6840

cgacgcagac gtattgaggt ccatgctaac agatccgccc cacatcacgg cggagactgc     6900

ggcgcggcgc ttggcacggg gatcacctcc atctgaggcg agctcctcag tgagccagct     6960

atcagcaccg tcgctgcggg ccacctgcac cacccacagc aacacctatg acgtggacat     7020

ggtcgatgcc aacctgctca tggggggcgg tgtggctcag acagagcctg agtccagggt     7080

gcccgctctg gactttctcg agccaatggc cgaggaagag agcgaccctg agccctcaat     7140

accatcggag tgcatgctcc ccaggagcgg gtttccacgg gccttaccgg cttgggcacg     7200

gcctgactac aacccgccgc tcgtggaatc gtggaggagg ccagattacc aaccgcccac     7260

cgttgctggt tgtgctctcc ccccccccaa gaaggccccg acgcctcccc caaggagacg     7320

ccggacagtg ggtctgagcg agagcaccac atcagaagcc ctccagcaac tggccatcaa     7380

gacctttggc cagcccccct cgagcggtga tgcaggctcg tccacggggg cgggcgccgc     7440

cgaatccggc ggtccgacgt cccctggtga gccggccccc tcagagacag gttccgcctc     7500

ctctatgccc cccctcgagg gggagcctgg agatccggac ctggagtctg atcaggtaga     7560

gcttcaacct cccccccagg gggggggggt agctcccggt tcgggctcgg ggtcttggtc     7620

tacttgctcc gaggaggacg ataccaccgt gtgctgctcc atgtcatact cctggaccgg     7680

ggctctaata actccctgta gccccgaaga ggaaaagttg ccaatcaacc ctttgagtaa     7740

ctcgctgttg cgataccata acaaggtgta ctgtacaaca tcaaagagcg cctcacagag     7800

ggctaaaaag gtaacttttg acaggacgca agtgctcgac gcccattatg actcagtctt     7860

aaaggacatc aagctagcgg cttccaaggt cagctcgagg ctcctcacct tggaggaggc     7920

gtgccagttg actccacccc attctgcaag atccaagtat ggattcgggg ccaaggaggt     7980

ccgcagcttg tccgggaggg ccgttaacca catcaagtcc gtgtggaagg acctcctgga     8040

agacccacaa acaccaattc ccacaaccat catggccaaa aatgaggtgt tctgcgtgga     8100

ccccgccaag gggggtaaga aaccagctcg cctcatcgtt taccctgacc tcggcgtccg     8160

ggtctgcgag aaaatggccc tctatgacat tacacaaaag cttcctcagg cggtaatggg     8220

agcttcctat ggcttccagt actcccctgc ccaacgggtg gagtatctct tgaaagcatg     8280

ggcggaaaag aaggacccca tgggtttttc gtatgatacc cgatgcttcg actcaaccgt     8340

cactgagaga gacatcagga ccgaggagtc catataccag gcctgctccc tgcccgagga     8400

ggcccgcact gccatacact cgctgactga gagactttac gtaggagggc ccatgttcaa     8460

cagcaagggt caaacctgcg gttacagacg ttgccgcgcc agcggggtgc taaccactag     8520

catgggtaac accatcacat gctatgtgaa agccctagcg gcctgcaagg ctgcggggat     8580

agttgcgccc acaatgctgg tatgcggcga tgacctagta gtcatctcag aaagccaggg     8640

gactgaggag gacgagcgga acctgagagc cttcacggag gccatgacca ggtactctgc     8700

ccctcctggt gatcccccca gaccggaata tgacctggag ctaataacat cctgttcctc     8760

aaatgtgtct gtggcgttgg gcccgcgggg ccgccgcaga tactacctga ccagagaccc     8820

aaccactcca ctcgcccggg ctgcctggga aacagttaga cactccccta tcaattcatg     8880

gctgggaaac atcatccagt atgctccaac catatgggct cgcatggtcc taatgacaca     8940

cttcttctcc attctcatgg tccaagacac cctggaccag aacctcaact ttgagatgta     9000

tggatcagta tactccgtga atcctttgga ccttccagcc ataattgaga ggttacacgg     9060

gcttgacgcc ttttctatgc acacatactc tcaccacgaa ctgacgcggg tggcttcagc     9120

cctcagaaaa cttggggcgc cacccctcag ggtgtggaag agtcgggctc gcgcagtcag     9180

ggcgtccctc atctcccgtg gagggaaagc ggccgtttgc ggccgatatc tcttcaattg     9240

ggcggtgaag accaagctca aactcactcc attgccggag gcgcgcctac tggacttatc     9300

cagttggttc accgtcggcg ccggcggggg cgacattttt cacagcgtgt cgcgcgcccg     9360

accccgctca ttactcttcg gcctactcct acttttcgta ggggtaggcc tcttcctact     9420

ccccgctcgg tagagcggca cacactaggt acactccata gctaactgtt cctttttttt     9480

tttttttttt tttttttttt tttttttttt tttttctttt tttttttttt ccctctttct     9540

tcccttctca tcttattcta ctttctttct tggtggctcc atcttagccc tagtcacggc     9600

tagctgtgaa aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc     9660

agatcatgt                                                             9669


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe used for HCV quantification

<400>  5
ccttgtggta ctgcctga                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer used for HCV quantification

<400>  6
agygttgggt ygcgaaag                                                     18


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer used for HCV quantification

<400>  7
cactcgcaag crccct                                                       16


