                         SEQUENCE LISTING

<110>  Firmenich SA
 
<120>  REDUCTION OF UNDESIRABLE TASTE NOTES IN ORAL CARE PRODUCTS

<130>  13750WO

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Gly Leu Thr Glu Gly Val Phe Leu Ile Leu Ser Gly Thr Gln 
1               5                   10                  15      


Phe Thr Leu Gly Ile Leu Val Asn Cys Phe Ile Glu Leu Val Asn Gly 
            20                  25                  30          


Ser Ser Trp Phe Lys Thr Lys Arg Met Ser Leu Ser Asp Phe Ile Ile 
        35                  40                  45              


Thr Thr Leu Ala Leu Leu Arg Ile Ile Leu Leu Cys Ile Ile Leu Thr 
    50                  55                  60                  


Asp Ser Phe Leu Ile Glu Phe Ser Pro Asn Thr His Asp Ser Gly Ile 
65                  70                  75                  80  


Ile Met Gln Ile Ile Asp Val Ser Trp Thr Phe Thr Asn His Leu Ser 
                85                  90                  95      


Ile Trp Leu Ala Thr Cys Leu Gly Val Leu Tyr Cys Leu Lys Ile Ala 
            100                 105                 110         


Ser Phe Ser His Pro Thr Phe Leu Trp Leu Lys Trp Arg Val Ser Arg 
        115                 120                 125             


Val Met Val Trp Met Leu Leu Gly Ala Leu Leu Leu Ser Cys Gly Ser 
    130                 135                 140                 


Thr Ala Ser Leu Ile Asn Glu Phe Lys Leu Tyr Ser Val Phe Arg Gly 
145                 150                 155                 160 


Ile Glu Ala Thr Arg Asn Val Thr Glu His Phe Arg Lys Lys Arg Ser 
                165                 170                 175     


Glu Tyr Tyr Leu Ile His Val Leu Gly Thr Leu Trp Tyr Leu Pro Pro 
            180                 185                 190         


Leu Ile Val Ser Leu Ala Ser Tyr Ser Leu Leu Ile Phe Ser Leu Gly 
        195                 200                 205             


Arg His Thr Arg Gln Met Leu Gln Asn Gly Thr Ser Ser Arg Asp Pro 
    210                 215                 220                 


Thr Thr Glu Ala His Lys Arg Ala Ile Arg Ile Ile Leu Ser Phe Phe 
225                 230                 235                 240 


Phe Leu Phe Leu Leu Tyr Phe Leu Ala Phe Leu Ile Ala Ser Phe Gly 
                245                 250                 255     


Asn Phe Leu Pro Lys Thr Lys Met Ala Lys Met Ile Gly Glu Val Met 
            260                 265                 270         


Thr Met Phe Tyr Pro Ala Gly His Ser Phe Ile Leu Ile Leu Gly Asn 
        275                 280                 285             


Ser Lys Leu Lys Gln Thr Phe Val Val Met Leu Arg Cys Glu Ser Gly 
    290                 295                 300                 


His Leu Lys Pro Gly Ser Lys Gly Pro Ile Phe Ser 
305                 310                 315     


<210>  2
<211>  299
<212>  PRT
<213>  homo sapiens

<400>  2

Met Leu Arg Leu Phe Tyr Phe Ser Ala Ile Ile Ala Ser Val Ile Leu 
1               5                   10                  15      


Asn Phe Val Gly Ile Ile Met Asn Leu Phe Ile Thr Val Val Asn Cys 
            20                  25                  30          


Lys Thr Trp Val Lys Ser His Arg Ile Ser Ser Ser Asp Arg Ile Leu 
        35                  40                  45              


Phe Ser Leu Gly Ile Thr Arg Phe Leu Met Leu Gly Leu Phe Leu Val 
    50                  55                  60                  


Asn Thr Ile Tyr Phe Val Ser Ser Asn Thr Glu Arg Ser Val Tyr Leu 
65                  70                  75                  80  


Ser Ala Phe Phe Val Leu Cys Phe Met Phe Leu Asp Ser Ser Ser Val 
                85                  90                  95      


Trp Phe Val Thr Leu Leu Asn Ile Leu Tyr Cys Val Lys Ile Thr Asn 
            100                 105                 110         


Phe Gln His Ser Val Phe Leu Leu Leu Lys Arg Asn Ile Ser Pro Lys 
        115                 120                 125             


Ile Pro Arg Leu Leu Leu Ala Cys Val Leu Ile Ser Ala Phe Thr Thr 
    130                 135                 140                 


Cys Leu Tyr Ile Thr Leu Ser Gln Ala Ser Pro Phe Pro Glu Leu Val 
145                 150                 155                 160 


Thr Thr Arg Asn Asn Thr Ser Phe Asn Ile Ser Glu Gly Ile Leu Ser 
                165                 170                 175     


Leu Val Val Ser Leu Val Leu Ser Ser Ser Leu Gln Phe Ile Ile Asn 
            180                 185                 190         


Val Thr Ser Ala Ser Leu Leu Ile His Ser Leu Arg Arg His Ile Gln 
        195                 200                 205             


Lys Met Gln Lys Asn Ala Thr Gly Phe Trp Asn Pro Gln Thr Glu Ala 
    210                 215                 220                 


His Val Gly Ala Met Lys Leu Met Val Tyr Phe Leu Ile Leu Tyr Ile 
225                 230                 235                 240 


Pro Tyr Ser Val Ala Thr Leu Val Gln Tyr Leu Pro Phe Tyr Ala Gly 
                245                 250                 255     


Met Asp Met Gly Thr Lys Ser Ile Cys Leu Ile Phe Ala Thr Leu Tyr 
            260                 265                 270         


Ser Pro Gly His Ser Val Leu Ile Ile Ile Thr His Pro Lys Leu Lys 
        275                 280                 285             


Thr Thr Ala Lys Lys Ile Leu Cys Phe Lys Lys 
    290                 295                 


<210>  3
<211>  318
<212>  PRT
<213>  homo sapiens

<400>  3

Met Ala Asp Lys Val Gln Thr Thr Leu Leu Phe Leu Ala Val Gly Glu 
1               5                   10                  15      


Phe Ser Val Gly Ile Leu Gly Asn Ala Phe Ile Gly Leu Val Asn Cys 
            20                  25                  30          


Met Asp Trp Val Lys Lys Arg Lys Ile Ala Ser Ile Asp Leu Ile Leu 
        35                  40                  45              


Thr Ser Leu Ala Ile Ser Arg Ile Cys Leu Leu Cys Val Ile Leu Leu 
    50                  55                  60                  


Asp Cys Phe Ile Leu Val Leu Tyr Pro Asp Val Tyr Ala Thr Gly Lys 
65                  70                  75                  80  


Glu Met Arg Ile Ile Asp Phe Phe Trp Thr Leu Thr Asn His Leu Ser 
                85                  90                  95      


Ile Trp Phe Ala Thr Cys Leu Ser Ile Tyr Tyr Phe Phe Lys Ile Gly 
            100                 105                 110         


Asn Phe Phe His Pro Leu Phe Leu Trp Met Lys Trp Arg Ile Asp Arg 
        115                 120                 125             


Val Ile Ser Trp Ile Leu Leu Gly Cys Val Val Leu Ser Val Phe Ile 
    130                 135                 140                 


Ser Leu Pro Ala Thr Glu Asn Leu Asn Ala Asp Phe Arg Phe Cys Val 
145                 150                 155                 160 


Lys Ala Lys Arg Lys Thr Asn Leu Thr Trp Ser Cys Arg Val Asn Lys 
                165                 170                 175     


Thr Gln His Ala Ser Thr Lys Leu Phe Leu Asn Leu Ala Thr Leu Leu 
            180                 185                 190         


Pro Phe Cys Val Cys Leu Met Ser Phe Phe Leu Leu Ile Leu Ser Leu 
        195                 200                 205             


Arg Arg His Ile Arg Arg Met Gln Leu Ser Ala Thr Gly Cys Arg Asp 
    210                 215                 220                 


Pro Ser Thr Glu Ala His Val Arg Ala Leu Lys Ala Val Ile Ser Phe 
225                 230                 235                 240 


Leu Leu Leu Phe Ile Ala Tyr Tyr Leu Ser Phe Leu Ile Ala Thr Ser 
                245                 250                 255     


Ser Tyr Phe Met Pro Glu Thr Glu Leu Ala Val Ile Phe Gly Glu Ser 
            260                 265                 270         


Ile Ala Leu Ile Tyr Pro Ser Ser His Ser Phe Ile Leu Ile Leu Gly 
        275                 280                 285             


Asn Asn Lys Leu Arg His Ala Ser Leu Lys Val Ile Trp Lys Val Met 
    290                 295                 300                 


Ser Ile Leu Lys Gly Arg Lys Phe Gln Gln His Lys Gln Ile 
305                 310                 315             


<210>  4
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  4

Met Phe Ser Pro Ala Asp Asn Ile Phe Ile Ile Leu Ile Thr Gly Glu 
1               5                   10                  15      


Phe Ile Leu Gly Ile Leu Gly Asn Gly Tyr Ile Ala Leu Val Asn Trp 
            20                  25                  30          


Ile Asp Trp Ile Lys Lys Lys Lys Ile Ser Thr Val Asp Tyr Ile Leu 
        35                  40                  45              


Thr Asn Leu Val Ile Ala Arg Ile Cys Leu Ile Ser Val Met Val Val 
    50                  55                  60                  


Asn Gly Ile Val Ile Val Leu Asn Pro Asp Val Tyr Thr Lys Asn Lys 
65                  70                  75                  80  


Gln Gln Ile Val Ile Phe Thr Phe Trp Thr Phe Ala Asn Tyr Leu Asn 
                85                  90                  95      


Met Trp Ile Thr Thr Cys Leu Asn Val Phe Tyr Phe Leu Lys Ile Ala 
            100                 105                 110         


Ser Ser Ser His Pro Leu Phe Leu Trp Leu Lys Trp Lys Ile Asp Met 
        115                 120                 125             


Val Val His Trp Ile Leu Leu Gly Cys Phe Ala Ile Ser Leu Leu Val 
    130                 135                 140                 


Ser Leu Ile Ala Ala Ile Val Leu Ser Cys Asp Tyr Arg Phe His Ala 
145                 150                 155                 160 


Ile Ala Lys His Lys Arg Asn Ile Thr Glu Met Phe His Val Ser Lys 
                165                 170                 175     


Ile Pro Tyr Phe Glu Pro Leu Thr Leu Phe Asn Leu Phe Ala Ile Val 
            180                 185                 190         


Pro Phe Ile Val Ser Leu Ile Ser Phe Phe Leu Leu Val Arg Ser Leu 
        195                 200                 205             


Trp Arg His Thr Lys Gln Ile Lys Leu Tyr Ala Thr Gly Ser Arg Asp 
    210                 215                 220                 


Pro Ser Thr Glu Val His Val Arg Ala Ile Lys Thr Met Thr Ser Phe 
225                 230                 235                 240 


Ile Phe Phe Phe Phe Leu Tyr Tyr Ile Ser Ser Ile Leu Met Thr Phe 
                245                 250                 255     


Ser Tyr Leu Met Thr Lys Tyr Lys Leu Ala Val Glu Phe Gly Glu Ile 
            260                 265                 270         


Ala Ala Ile Leu Tyr Pro Leu Gly His Ser Leu Ile Leu Ile Val Leu 
        275                 280                 285             


Asn Asn Lys Leu Arg Gln Thr Phe Val Arg Met Leu Thr Cys Arg Lys 
    290                 295                 300                 


Ile Ala Cys Met Ile 
305                 


<210>  5
<211>  312
<212>  PRT
<213>  homo sapiens

<400>  5

Met Pro Ser Ala Ile Glu Ala Ile Tyr Ile Ile Leu Ile Ala Gly Glu 
1               5                   10                  15      


Leu Thr Ile Gly Ile Trp Gly Asn Gly Phe Ile Val Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Trp Leu Lys Arg Arg Asp Ile Ser Leu Ile Asp Ile Ile Leu 
        35                  40                  45              


Ile Ser Leu Ala Ile Ser Arg Ile Cys Leu Leu Cys Val Ile Ser Leu 
    50                  55                  60                  


Asp Gly Phe Phe Met Leu Leu Phe Pro Gly Thr Tyr Gly Asn Ser Val 
65                  70                  75                  80  


Leu Val Ser Ile Val Asn Val Val Trp Thr Phe Ala Asn Asn Ser Ser 
                85                  90                  95      


Leu Trp Phe Thr Ser Cys Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala 
            100                 105                 110         


Asn Ile Ser His Pro Phe Phe Phe Trp Leu Lys Leu Lys Ile Asn Lys 
        115                 120                 125             


Val Met Leu Ala Ile Leu Leu Gly Ser Phe Leu Ile Ser Leu Ile Ile 
    130                 135                 140                 


Ser Val Pro Lys Asn Asp Asp Met Trp Tyr His Leu Phe Lys Val Ser 
145                 150                 155                 160 


His Glu Glu Asn Ile Thr Trp Lys Phe Lys Val Ser Lys Ile Pro Gly 
                165                 170                 175     


Thr Phe Lys Gln Leu Thr Leu Asn Leu Gly Ala Met Val Pro Phe Ile 
            180                 185                 190         


Leu Cys Leu Ile Ser Phe Phe Leu Leu Leu Phe Ser Leu Val Arg His 
        195                 200                 205             


Thr Lys Gln Ile Arg Leu His Ala Thr Gly Phe Arg Asp Pro Ser Thr 
    210                 215                 220                 


Glu Ala His Met Arg Ala Ile Lys Ala Val Ile Ile Phe Leu Leu Leu 
225                 230                 235                 240 


Leu Ile Val Tyr Tyr Pro Val Phe Leu Val Met Thr Ser Ser Ala Leu 
                245                 250                 255     


Ile Pro Gln Gly Lys Leu Val Leu Met Ile Gly Asp Ile Val Thr Val 
            260                 265                 270         


Ile Phe Pro Ser Ser His Ser Phe Ile Leu Ile Met Gly Asn Ser Lys 
        275                 280                 285             


Leu Arg Glu Ala Phe Leu Lys Met Leu Arg Phe Val Lys Cys Phe Leu 
    290                 295                 300                 


Arg Arg Arg Lys Pro Phe Val Pro 
305                 310         


<210>  6
<211>  307
<212>  PRT
<213>  homo sapiens

<400>  6

Met Leu Arg Val Val Glu Gly Ile Phe Ile Phe Val Val Val Ser Glu 
1               5                   10                  15      


Ser Val Phe Gly Val Leu Gly Asn Gly Phe Ile Gly Leu Val Asn Cys 
            20                  25                  30          


Ile Asp Cys Ala Lys Asn Lys Leu Ser Thr Ile Gly Phe Ile Leu Thr 
        35                  40                  45              


Gly Leu Ala Ile Ser Arg Ile Phe Leu Ile Trp Ile Ile Ile Thr Asp 
    50                  55                  60                  


Gly Phe Ile Gln Ile Phe Ser Pro Asn Ile Tyr Ala Ser Gly Asn Leu 
65                  70                  75                  80  


Ile Glu Tyr Ile Ser Tyr Phe Trp Val Ile Gly Asn Gln Ser Ser Met 
                85                  90                  95      


Trp Phe Ala Thr Ser Leu Ser Ile Phe Tyr Phe Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Tyr Ile Phe Leu Trp Leu Lys Ser Arg Thr Asn Met Val 
        115                 120                 125             


Leu Pro Phe Met Ile Val Phe Leu Leu Ile Ser Ser Leu Leu Asn Phe 
    130                 135                 140                 


Ala Tyr Ile Ala Lys Ile Leu Asn Asp Tyr Lys Met Lys Asn Asp Thr 
145                 150                 155                 160 


Val Trp Asp Leu Asn Met Tyr Lys Ser Glu Tyr Phe Ile Lys Gln Ile 
                165                 170                 175     


Leu Leu Asn Leu Gly Val Ile Phe Phe Phe Thr Leu Ser Leu Ile Thr 
            180                 185                 190         


Cys Ile Phe Leu Ile Ile Ser Leu Trp Arg His Asn Arg Gln Met Gln 
        195                 200                 205             


Ser Asn Val Thr Gly Leu Arg Asp Ser Asn Thr Glu Ala His Val Lys 
    210                 215                 220                 


Ala Met Lys Val Leu Ile Ser Phe Ile Ile Leu Phe Ile Leu Tyr Phe 
225                 230                 235                 240 


Ile Gly Met Ala Ile Glu Ile Ser Cys Phe Thr Val Arg Glu Asn Lys 
                245                 250                 255     


Leu Leu Leu Met Phe Gly Met Thr Thr Thr Ala Ile Tyr Pro Trp Gly 
            260                 265                 270         


His Ser Phe Ile Leu Ile Leu Gly Asn Ser Lys Leu Lys Gln Ala Ser 
        275                 280                 285             


Leu Arg Val Leu Gln Gln Leu Lys Cys Cys Glu Lys Arg Lys Asn Leu 
    290                 295                 300                 


Arg Val Thr 
305         


<210>  7
<211>  321
<212>  PRT
<213>  homo sapiens

<400>  7

Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe Leu 
1               5                   10                  15      


Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly Ile 
            20                  25                  30          


Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val Gln 
        35                  40                  45              


Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser Val 
    50                  55                  60                  


Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile Ser 
65                  70                  75                  80  


Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala Phe 
                85                  90                  95      


Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala Ala 
            100                 105                 110         


Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr Pro 
        115                 120                 125             


Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp Leu 
    130                 135                 140                 


Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys Ile 
145                 150                 155                 160 


Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser Ser 
                165                 170                 175     


Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly Leu 
            180                 185                 190         


Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe Ile 
        195                 200                 205             


Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu His 
    210                 215                 220                 


Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala His 
225                 230                 235                 240 


Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile Phe 
                245                 250                 255     


Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile Asn 
            260                 265                 270         


Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro Ala 
        275                 280                 285             


Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg Ala 
    290                 295                 300                 


Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp Thr 
305                 310                 315                 320 


Leu 
    


<210>  8
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  8

Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ser Leu Val Val Val Thr 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Asn Ser Val Glu Val 
65                  70                  75                  80  


Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Ile Asn His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Thr Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn 
                165                 170                 175     


Met Thr Val Thr Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Leu Ser Phe Met Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 
            260                 265                 270         


Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Phe Trp Gln Met Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Thr Ser Ser Pro 
305                 


<210>  9
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  9

Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala 
1               5                   10                  15      


Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe 
            20                  25                  30          


Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile 
        35                  40                  45              


Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 
    50                  55                  60                  


His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val 
65                  70                  75                  80  


Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn 
            100                 105                 110         


Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu 
    130                 135                 140                 


Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly 
145                 150                 155                 160 


Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn 
                165                 170                 175     


Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Arg Pro 
                245                 250                 255     


Lys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro 
            260                 265                 270         


Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln 
    290                 295                 300                 


Asn Gln Ser Thr Pro 
305                 


<210>  10
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  10

Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val 
65                  70                  75                  80  


Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp 
                165                 170                 175     


Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Val Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 
            260                 265                 270         


Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Pro Ser Ser Pro 
305                 


<210>  11
<211>  299
<212>  PRT
<213>  homo sapiens

<400>  11

Met Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu 
1               5                   10                  15      


Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe 
            20                  25                  30          


Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu 
    50                  55                  60                  


Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 
65                  70                  75                  80  


Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met 
                85                  90                  95      


Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val 
        115                 120                 125             


Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu 
    130                 135                 140                 


Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr 
                165                 170                 175     


Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu 
            180                 185                 190         


Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg 
                245                 250                 255     


Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu 
            260                 265                 270         


Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His 
        275                 280                 285             


Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys 
    290                 295                 


<210>  12
<211>  307
<212>  PRT
<213>  homo sapiens

<400>  12

Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 
1               5                   10                  15      


Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 
            20                  25                  30          


Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 
        35                  40                  45              


Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 
    50                  55                  60                  


His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 
65                  70                  75                  80  


Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 
                85                  90                  95      


Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 
            100                 105                 110         


Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 
        115                 120                 125             


Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 
    130                 135                 140                 


Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 
145                 150                 155                 160 


Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 
                165                 170                 175     


Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 
            180                 185                 190         


Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 
        195                 200                 205             


Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 
225                 230                 235                 240 


Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 
                245                 250                 255     


Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 
            260                 265                 270         


Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 
        275                 280                 285             


Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 
    290                 295                 300                 


Trp Val Ala 
305         


<210>  13
<211>  309
<212>  PRT
<213>  homo sapiens

<400>  13

Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Thr 
1               5                   10                  15      


Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 
            20                  25                  30          


Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 
        35                  40                  45              


Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Val Leu 
    50                  55                  60                  


Asn Trp Tyr Ala Thr Glu Leu Asn Pro Ala Phe Asn Ser Ile Glu Val 
65                  70                  75                  80  


Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Ile Asn His Phe Ser Asn 
                85                  90                  95      


Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 
            100                 105                 110         


Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 
        115                 120                 125             


Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu 
    130                 135                 140                 


Phe Val Ile Asn Met Asn Gln Ile Ile Trp Thr Lys Glu Tyr Glu Gly 
145                 150                 155                 160 


Asn Met Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr Leu Ser Asn 
                165                 170                 175     


Thr Thr Val Thr Ile Leu Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 
            180                 185                 190         


Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 
        195                 200                 205             


Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Met Lys Val His 
    210                 215                 220                 


Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile 
225                 230                 235                 240 


Tyr Phe Leu Ser Ile Ile Met Ser Val Trp Ser Phe Glu Ser Leu Glu 
                245                 250                 255     


Asn Lys Pro Val Phe Met Phe Cys Glu Ala Ile Ala Phe Ser Tyr Pro 
            260                 265                 270         


Ser Thr His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 
        275                 280                 285             


Thr Phe Leu Ser Val Leu Trp His Val Arg Tyr Trp Val Lys Gly Glu 
    290                 295                 300                 


Lys Pro Ser Ser Ser 
305                 


