                               SEQUENCE LISTING

<110> REGENTS OF THE UNIVERSITY OF MINNESOTA
 
<120> SARS-COV-2 NANOBODIES AND METHODS OF USE THEREOF

<130> 09531-519WO1

<140> PCT/US2021/041328
<141> 2021-07-12

<150> 63/075,701
<151> 2020-09-08

<150> 63/052,140
<151> 2020-07-15

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr His 
                85                  90                  95      


Gly Met Ala Gly Ser Lys Ser Gly Gln Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gly Phe Thr Phe Lys Asn Ala Asp 
1               5               


<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Ile Tyr Ser Asp Gly Ser Thr 
1               5           


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Met Ala Gly Ser Lys Ser Gly Gln Glu Leu Asp His 
1               5                   10          


<210> 5
<211> 143
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr His 
                85                  90                  95      


Gly Met Ala Gly Ser Lys Ser Gly Gln Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Pro Gly Gly Gln His His His 
        115                 120                 125             


His His His Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
    130                 135                 140             


<210> 6
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr His 
                85                  90                  95      


Gly Met Ala Gly Ser Lys Ser Gly Gln Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210> 7
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His 
1               5                   10          


<210> 9
<211> 143
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Pro Gly Gly Gln His His His 
        115                 120                 125             


His His His Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
    130                 135                 140             


<210> 10
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Ser Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210> 11
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Val Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Arg Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ile Tyr Ser Asp Gly Arg Thr 
1               5           


<210> 13
<211> 143
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Val Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Arg Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Pro Gly Gly Gln His His His 
        115                 120                 125             


His His His Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
    130                 135                 140             


<210> 14
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys 
            20                  25                  30          


Asn Ala Asp Met Asn Trp Tyr Arg Gln Val Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Thr Ser Ile Tyr Ser Asp Gly Arg Thr Val Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Pro Lys Ser Thr Val 
65                  70                  75                  80  


Ser Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Met Ala Gly Ser Lys Ser Gly His Glu Leu Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Pro Gly Gly Gln 
1               5   


<210> 16
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 16
His His His His His His 
1               5       


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
1               5                   10          


<210> 18
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
His His His His His His Gly Ala Tyr Pro Tyr Asp Val Pro Asp Tyr 
1               5                   10                  15      


Ala Ser 
        


<210> 19
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> S or R

<400> 20
Ile Tyr Ser Asp Gly Xaa Thr 
1               5           


<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Q or H

<400> 21
Met Ala Gly Ser Lys Ser Gly Xaa Glu Leu Asp His 
1               5                   10          


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 23
<211> 429
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggcaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagtacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctatcatgg tatggcaggt      300

tcaaagtcgg gccaagagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360

ggcccgggag gccaacacca tcaccaccat catggcgcat atccgtatga tgtgccggac      420

tatgcttct                                                              429


<210> 24
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggcaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagtacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctatcatgg tatggcaggt      300

tcaaagtcgg gccaagagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      420

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      480

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      540

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      600

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      660

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      720

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      780

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      840

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      900

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      960

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1020

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1056


<210> 25
<211> 429
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggcaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagtacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctattattg tatggcaggt      300

tcaaagtcgg gccatgagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360

ggcccgggag gccaacacca tcaccaccat catggcgcat atccgtatga tgtgccggac      420

tatgcttct                                                              429


<210> 26
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggcaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagtacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctattattg tatggcaggt      300

tcaaagtcgg gccatgagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      420

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      480

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      540

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      600

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      660

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      720

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      780

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      840

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      900

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      960

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1020

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1056


<210> 27
<211> 429
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggtaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagaacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctattattg tatggcaggt      300

tcaaagtcgg gccatgagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360

ggcccgggag gccaacacca tcaccaccat catggcgcat atccgtatga tgtgccggac      420

tatgcttct                                                              429


<210> 28
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggtaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagaacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctattattg tatggcaggt      300

tcaaagtcgg gccatgagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      420

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      480

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      540

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      600

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      660

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      720

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      780

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      840

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      900

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      960

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1020

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1056


<210> 29
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggcaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagtacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctatcatgg tatggcaggt      300

tcaaagtcgg gccaagagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360


<210> 30
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggcaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagtacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctattattg tatggcaggt      300

tcaaagtcgg gccatgagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360


<210> 31
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
atggctcagg tgcagctcgt ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agactctcct gtgcagcctc tggcttcacc ttcaaaaacg cggacatgaa ctggtatcgc      120

caggtaccag gtcaggggct cgagtgggtg actagtattt atagtgacgg tagaacagtc      180

tatgcagact ccgtgaaggg ccgattcacc gtctccagag acaaccccaa gagcacggtg      240

tctctgcaaa tgaacagcct gaaacctgag gacacaggtg tctattattg tatggcaggt      300

tcaaagtcgg gccatgagtt ggatcattgg ggccagggga cccaggtcac cgtctccagc      360


