                         SEQUENCE LISTING

<110>  GENENTECH, INC.
 
<120>  ANTI-NOTCH2 ANTIBODIES AND METHODS OF USE

<130>  01146-0094-00PCT

<150>  US 63/053,034
<151>  2020-07-17

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-L1 of rat1B2, hu1B2.L1, hu1B2.L7, hu1B2.v101, 
       hu1B2.v102, hu1B2.v103, hu1B2.v104

<400>  1

Gln Thr Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-L2 of rat1B2, hu1B2.L1, hu1B2.L7, hu1B2.v101, 
       hu1B2.v102, hu1B2.v103, hu1B2.v104

<400>  2

Gly Ala Ser Arg Leu Gln Asp 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-L3 of rat1B2, hu1B2.L1, hu1B2.L7, hu1B2.v101, 
       hu1B2.v102, hu1B2.v103, hu1B2.v104

<400>  3

Gln Gln Gly Phe Lys Tyr Pro Leu Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H1 of rat1B2, hu.1B2.v1.DFS.H1, hu.1B2.H10, 
       hu.1B2.DFS.H14, hu.1B2.H1.N54D.S51Q, hu.1B2.v2, hu.1B2.v4, 
       hu.1B2.v8, hu.1B2.v9, hu1B2.v101, hu1B2.v102, hu1B2.v103, 
       hu1B2.v104

<400>  4

Asp Phe Tyr Met Glu 
1               5   


<210>  5
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H2 of rat1B2

<400>  5

Ala Ser Arg Asn Lys Ala Asn Asn Phe Ser Ile Val Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H2 of hu.1B2.v1.DFS.H1, hu.1B2.H10, hu.1B2.DFS.H14

<400>  6

Ala Ser Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H2 of hu.1B2.H1.N54D.S51Q, hu.1B2.v2, hu.1B2.v4, 
       hu.1B2.v8, hu.1B2.v9, hu1B2.v101, hu1B2.v102, hu1B2.v103, 
       hu1B2.v104

<400>  7

Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H3 of rat1B2, hu.1B2.v1.DFS.H1, hu.1B2.H10, 
       hu.1B2.DFS.H14, hu.1B2.H1.N54D.S51Q

<400>  8

Asp Ser Gly Arg Trp Gly Leu Asp Ala 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H3 of hu.1B2.v2, hu1B2.v101

<400>  9

Asp Gly Gly Arg Trp Gly Leu Asp Ala 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H3 of hu.1B2.v4, hu1B2.v102

<400>  10

Asp Gly Gly Arg Leu Ala Leu Asp Ala 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H3 of hu.1B2.v8, hu1B2.v104

<400>  11

Asp Gly Gly Lys Leu Ala Leu Asp Ala 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CDR-H3 of hu.1B2.v9, hu1B2.v103

<400>  12

Asp Gly Gly Lys Trp Gly Leu Asp Ala 
1               5                   


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.1B2 Light Chain Variable Region (VL)

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Gln Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Ser Met Gln Thr 
65                  70                  75                  80  


Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.1B2 Heavy Chain Variable Region (VH)

<400>  14

Glu Val Lys Leu Val Asp Tyr Gly Gly Gly Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asn Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Tyr Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Ser Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Ile Val Ser Ser 
        115                 120 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.L1 VL

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.L7 VL

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v1.DFS.H1 VH

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Ser Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.H10 VH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Ser Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.DFS.H14 VH

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Ser Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.H1.N54D.S51Q VH

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Ser Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v2 VH

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v4 VH

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Arg Leu Ala Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v8 VH

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Lys Leu Ala Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v9 VH

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Lys Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v101 VL

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v101 VH

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Arg Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v102 VL

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v102 VH

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Arg Leu Ala Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v103 VL

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  30
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v103 VH

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Lys Trp Gly Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v104 VL

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Thr Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Lys Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  32
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.1B2.v104 VH

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Gln Arg Asn Lys Ala Asn Asp Phe Ser Ile Val Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asp Gly Gly Lys Leu Ala Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 CDR-L1, hu.3107.L1, hu.3107.L6, and 
       hu.3107.L7

<400>  33

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 CDR-L2, hu.3107.L1, hu.3107.L6, and 
       hu.3107.L7

<400>  34

Arg Ile Ser Asn Arg Phe Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 CDR-L3, hu.3107.L1, hu.3107.L6, and 
       hu.3107.L7

<400>  35

Leu Gln Ser Thr His Phe Pro Asp Thr 
1               5                   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 CDR-H1, hu.3107.V1-2.H1, hu.3107.H12, 
       hu.3107.H13, hu.3107.V5-51.H1, hu.3107.H14, and hu.3107.H15

<400>  36

Asn Tyr Val Ile His 
1               5   


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 CDR-H2, hu.3107.V1-2.H1, hu.3107.H12, 
       hu.3107.H13, hu.3107.V5-51.H1, hu.3107.H14, and hu.3107.H15

<400>  37

Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 CDR-H3, hu.3107.V1-2.H1, hu.3107.H12, 
       hu.3107.H13, hu.3107.V5-51.H1, hu.3107.H14, and hu.3107.H15

<400>  38

Asp Gly Ala Gly Ser Phe Thr Tyr 
1               5               


<210>  39
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 VL

<400>  39

Asp Val Leu Met Thr Gln Thr Pro Val Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Gly Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Ser 
                85                  90                  95      


Thr His Phe Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  40
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rat.3107 VH

<400>  40

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Ser Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Ile Lys Gln Thr Thr Gly Gln Ala Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 CDR-L1

<400>  41

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 CDR-L2

<400>  42

Arg Ala Ser Lys Leu Ala Ser 
1               5           


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 CDR-L3

<400>  43

Gln Ser Asn Ser Tyr Gly Asn Asn Trp Val Gly Gly 
1               5                   10          


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 CDR-H1

<400>  44

Ser Gly Tyr Asp Met Cys 
1               5       


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 CDR-H2

<400>  45

Cys Ile Tyr Ala Gly Ser Glu Gly Phe Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys 
    


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 CDR-H3

<400>  46

Trp Thr Asp Ser Asp Gly Ser Asn Leu 
1               5                   


<210>  47
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 VL

<400>  47

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Ser Tyr Gly Asn Asn 
                85                  90                  95      


Trp Val Gly Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  48
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2338 VH

<400>  48

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 
            20                  25                  30          


Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Ala Gly Ser Glu Gly Phe Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Ser Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Val Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Thr Asp Ser Asp Gly Ser Asn Leu Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430, rb.2430.C95dS CDR-L1

<400>  49

Gln Ala Ser Gln Ser Val Val Asn Asn Arg Leu Ala 
1               5                   10          


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430, rb.2430.C95dS CDR-L2

<400>  50

Gly Ala Ser Thr Leu Glu Ser 
1               5           


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430 CDR-L3

<400>  51

Gln Gly Glu Phe Leu Cys Ser Ser Gly Asp Cys Val Ala 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430.C95dS CDR-L3

<400>  52

Gln Gly Glu Phe Leu Cys Ser Ser Gly Asp Ser Val Ala 
1               5                   10              


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430, rb.2430.C95dS CDR-H1

<400>  53

Ser Tyr Asp Met Ser 
1               5   


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430 , rb.2430.C95dS CDR-H2

<400>  54

Ile Ile Gln Ala Gly Ser Asn Thr Leu Phe Tyr Ala Ser Trp Ala 
1               5                   10                  15  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430, rb.2430.C95dS CDR-H3

<400>  55

Gly Gly Val Ile Phe Ile Ile Gly His Phe Asn Leu 
1               5                   10          


<210>  56
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430 VL

<400>  56

Ala Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Val Asn Asn 
            20                  25                  30          


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Met Tyr Gly Ala Ser Thr Leu Glu Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Leu Cys Ser 
                85                  90                  95      


Ser Gly Asp Cys Val Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  57
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430.C95dS VL

<400>  57

Ala Gln Val Leu Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Val Asn Asn 
            20                  25                  30          


Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Met Tyr Gly Ala Ser Thr Leu Glu Ser Gly Val Ser Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Glu Phe Leu Cys Ser 
                85                  90                  95      


Ser Gly Asp Ser Val Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  58
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2430 VH

<400>  58

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Gln Ala Gly Ser Asn Thr Leu Phe Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Val Ile Phe Ile Ile Gly His Phe Asn Leu Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 CDR-L1

<400>  59

Gln Ala Ser Glu Ser Ile Gly Ser Tyr Leu Ala 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 CDR-L2

<400>  60

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 CDR-L3

<400>  61

Gln Gln Thr Tyr Ser Gly Ala Gly Val Asp Asn Leu 
1               5                   10          


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 CDR-H1

<400>  62

Ser Gly Tyr Asp Met Cys 
1               5       


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 CDR-H2

<400>  63

Cys Ile Val Thr Val Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 CDR-H3

<400>  64

Asp Gly Gly Phe Thr Asp Thr Trp Tyr Phe His Leu 
1               5                   10          


<210>  65
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 VL

<400>  65

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Gly Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Gly Ala Gly 
                85                  90                  95      


Val Asp Asn Leu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  66
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: rb.2621 VH

<400>  66

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 
            20                  25                  30          


Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Val Thr Val Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Phe Thr Asp Thr Trp Tyr Phe His Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MBP-huNotch2 EGF6-10

<400>  67

Ala Gly Ser Met Gly Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile 
1               5                   10                  15      


Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe 
            20                  25                  30          


Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu 
        35                  40                  45              


Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile 
    50                  55                  60                  


Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu 
65                  70                  75                  80  


Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro 
                85                  90                  95      


Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro 
            100                 105                 110         


Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro 
        115                 120                 125             


Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu 
    130                 135                 140                 


Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr 
145                 150                 155                 160 


Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr 
                165                 170                 175     


Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly 
            180                 185                 190         


Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His 
        195                 200                 205             


Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys 
    210                 215                 220                 


Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile 
225                 230                 235                 240 


Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys 
                245                 250                 255     


Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn 
            260                 265                 270         


Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr 
        275                 280                 285             


Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu 
    290                 295                 300                 


Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro 
305                 310                 315                 320 


Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro 
                325                 330                 335     


Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val 
            340                 345                 350         


Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp 
        355                 360                 365             


Ala Gln Thr Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn 
    370                 375                 380                 


Asn Gly Glu Asn Leu Tyr Phe Gln Gly Ser Asp Ser Leu Tyr Val Pro 
385                 390                 395                 400 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
                405                 410                 415     


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
            420                 425                 430         


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
        435                 440                 445             


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
    450                 455                 460                 


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
465                 470                 475                 480 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
                485                 490                 495     


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
            500                 505                 510         


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
        515                 520                 525             


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
    530                 535                 540                 


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
545                 550                 555                 560 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
                565                 570                 575     


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
            580                 585                 590         


Asp Glu Gly Asn Ser His His His His His His His His 
        595                 600                 605 


<210>  68
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MBP-huNotch2 EGF7-9

<400>  68

Ala Gly Ser Met Gly Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile 
1               5                   10                  15      


Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe 
            20                  25                  30          


Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu 
        35                  40                  45              


Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile 
    50                  55                  60                  


Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu 
65                  70                  75                  80  


Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro 
                85                  90                  95      


Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro 
            100                 105                 110         


Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro 
        115                 120                 125             


Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu 
    130                 135                 140                 


Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr 
145                 150                 155                 160 


Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr 
                165                 170                 175     


Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly 
            180                 185                 190         


Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His 
        195                 200                 205             


Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys 
    210                 215                 220                 


Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile 
225                 230                 235                 240 


Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys 
                245                 250                 255     


Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn 
            260                 265                 270         


Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr 
        275                 280                 285             


Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu 
    290                 295                 300                 


Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro 
305                 310                 315                 320 


Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro 
                325                 330                 335     


Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val 
            340                 345                 350         


Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp 
        355                 360                 365             


Ala Gln Thr Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn 
    370                 375                 380                 


Asn Gly Glu Asn Leu Tyr Phe Gln Gly Ser Glu Arg Asn Ile Asp Asp 
385                 390                 395                 400 


Cys Pro Asn His Arg Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
                405                 410                 415     


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
            420                 425                 430         


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
        435                 440                 445             


Gly Gly Thr Cys Ala Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
    450                 455                 460                 


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
465                 470                 475                 480 


Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
                485                 490                 495     


Phe Ser Cys Met Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
            500                 505                 510         


Asp Asp Ala Gly Asn Ser His His His His His His His His 
        515                 520                 525     


<210>  69
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch2 EGF7 (amino acids 260-296); cynoNotch2 EGF7 
       (amino acids 260-296)guinea pig Notch2 EGF7 (amino acids 244-280)

<400>  69

Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly Gly Val Cys 
1               5                   10                  15      


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr 
            20                  25                  30          


Gly Gln Phe Cys Thr 
        35          


<210>  70
<211>  2471
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2471)
<223>  Human Notch2, with signal sequence (amino acids 1-25)

<400>  70

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  71
<211>  2471
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  misc_feature
<222>  (1)..(2471)
<223>  Cynomolgus monkey Notch2, with signal sequence (amino acids 1-25)

<400>  71

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Arg Ala Ala Pro Ala Arg Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln His Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Leu  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr His Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Ile Gln  Asp Lys Ala 
    1070                 1075                 1080             


Glu Ser  Arg Cys Arg Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Val Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Asn  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Trp Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Ala Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Ile  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Ser Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Asn  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Ser Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Pro Pro Ser Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Ser Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Thr Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  72
<211>  2455
<212>  PRT
<213>  Cavia porcellus


<220>
<221>  misc_feature
<222>  (1)..(2455)
<223>  Guinea pig Notch2, with signal sequence (amino acids 1-9)

<400>  72

Met Tyr Leu Phe Cys Phe Val Leu Ala Leu Gln Cys Arg Asp Asp Tyr 
1               5                   10                  15      


Glu Pro Cys Val Asn Glu Gly Ile Cys Val Thr Tyr His Asn Gly Thr 
            20                  25                  30          


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
        35                  40                  45              


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
    50                  55                  60                  


Ala Gln Ala Met Leu Gly Arg Ala Thr Cys Arg Cys Ala Leu Gly Phe 
65                  70                  75                  80  


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Asn 
                85                  90                  95      


Pro Pro Cys Gln Asn Gly Gly Thr Cys His Met Leu Ser Trp Asp Thr 
            100                 105                 110         


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Leu Cys Gln Trp 
        115                 120                 125             


Ile Asp Ala Cys Leu Ser Gln Pro Cys Ala Asn Gly Ser Thr Cys Thr 
    130                 135                 140                 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Ala Gly Phe Thr Gly 
145                 150                 155                 160 


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly Gln Cys 
                165                 170                 175     


Gln Asn Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
            180                 185                 190         


Cys Ser Gln Gly Phe Thr Gly Gln His Cys Asp Asn Pro Tyr Val Pro 
        195                 200                 205             


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
    210                 215                 220                 


Asp Phe Thr Phe Glu Cys Ser Cys Leu Pro Gly Phe Glu Gly Ser Thr 
225                 230                 235                 240 


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
                245                 250                 255     


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
            260                 265                 270         


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
        275                 280                 285             


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Thr Asn Arg Asn Gly 
    290                 295                 300                 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
305                 310                 315                 320 


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
                325                 330                 335     


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
            340                 345                 350         


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
        355                 360                 365             


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly His Tyr Ile 
    370                 375                 380                 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
385                 390                 395                 400 


Asp Glu Cys Ala Met Thr Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
                405                 410                 415     


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
            420                 425                 430         


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
        435                 440                 445             


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
    450                 455                 460                 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Ile Glu Ile Asn 
465                 470                 475                 480 


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
                485                 490                 495     


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
            500                 505                 510         


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
        515                 520                 525             


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
    530                 535                 540                 


Gly Phe Thr Gly Leu Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
545                 550                 555                 560 


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
                565                 570                 575     


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
            580                 585                 590         


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Glu Gly Arg Cys Ile Asp 
        595                 600                 605             


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
    610                 615                 620                 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Ser Pro Cys Val Asn 
625                 630                 635                 640 


Gly Thr Cys Val Asp Gly Ile Ser Arg Tyr Ser Cys Val Cys Ser Pro 
                645                 650                 655     


Gly Phe Thr Gly Gln Arg Cys Asn Val Asp Ile Asp Glu Cys Ala Ser 
            660                 665                 670         


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Asp Val Asn Gly Phe 
        675                 680                 685             


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
    690                 695                 700                 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Ser Cys Ile Gly 
705                 710                 715                 720 


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
                725                 730                 735     


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
            740                 745                 750         


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Lys Cys Thr Cys Lys 
        755                 760                 765             


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
    770                 775                 780                 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Val Ser Gly 
785                 790                 795                 800 


Tyr Thr Cys Gln Cys Ala Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
                805                 810                 815     


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
            820                 825                 830         


Lys Glu Ala Pro Asn Phe Glu Ser Phe Thr Cys Leu Cys Ala Pro Gly 
        835                 840                 845             


Trp Gln Gly Gln Arg Cys Thr Val Asp Ile Asp Glu Cys Val Ser Lys 
    850                 855                 860                 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
865                 870                 875                 880 


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
                885                 890                 895     


Asn Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp 
            900                 905                 910         


Gly Val Asn Thr Phe Ser Cys Met Cys Leu Pro Gly Phe Ile Gly Asp 
        915                 920                 925             


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
    930                 935                 940                 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
945                 950                 955                 960 


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr 
                965                 970                 975     


Asp Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
            980                 985                 990         


Phe Ser Cys Leu Cys Pro Val Gly  Phe Thr Gly Pro Phe  Cys Leu His 
        995                 1000                 1005             


Glu Ile  Asn Glu Cys Ser Ser  His Pro Cys Leu Asn  Glu Gly Thr 
    1010                 1015                 1020             


Cys Val  Asp Gly Leu Gly Thr  Tyr Arg Cys Thr Cys  Pro Leu Gly 
    1025                 1030                 1035             


Tyr Thr  Gly Lys Asn Cys Gln  Thr Leu Val Asn Leu  Cys Ser Gln 
    1040                 1045                 1050             


Ser Pro  Cys Lys Asn Lys Gly  Thr Cys Ile Gln Glu  Lys Ala Glu 
    1055                 1060                 1065             


Ser Arg  Cys Leu Cys Pro Ser  Gly Trp Thr Gly Ala  Tyr Cys Asp 
    1070                 1075                 1080             


Val Pro  Asn Val Ser Cys Asp  Val Ala Ala Leu Asn  Lys Gly Val 
    1085                 1090                 1095             


Leu Ala  Lys Asn Leu Cys Lys  Asn Ser Gly Ala Cys  Ile Asn Ala 
    1100                 1105                 1110             


Gly Asn  Thr His His Cys Gln  Cys Pro Leu Gly Tyr  Thr Gly Ser 
    1115                 1120                 1125             


Tyr Cys  Glu Gln Gln Leu Asp  Glu Cys Ala Ser Asn  Pro Cys Lys 
    1130                 1135                 1140             


His Gly  Ala Thr Cys Thr Asp  Phe Ile Gly Gly Tyr  Arg Cys Glu 
    1145                 1150                 1155             


Cys Val  Pro Gly Tyr Gln Gly  Val Asn Cys Glu Tyr  Glu Val Asp 
    1160                 1165                 1170             


Glu Cys  Gln Asn Gln Pro Cys  Arg Asn Gly Gly Thr  Cys Val Asp 
    1175                 1180                 1185             


Leu Val  Asn His Phe Lys Cys  Ser Cys Pro Pro Gly  Thr Arg Gly 
    1190                 1195                 1200             


Leu Phe  Cys Glu Glu Asn Ile  Asp Asp Cys Ala Gly  Gly Pro His 
    1205                 1210                 1215             


Cys Leu  Asn Gly Gly Gln Cys  Val Asp Arg Ile Gly  Gly Tyr Ser 
    1220                 1225                 1230             


Cys Arg  Cys Leu Pro Gly Phe  Ala Gly Glu Arg Cys  Glu Gly Asp 
    1235                 1240                 1245             


Ile Asn  Glu Cys Leu Ser Asn  Pro Cys Asn Ser Glu  Gly Ser Leu 
    1250                 1255                 1260             


Asp Cys  Ile Gln Leu Thr Asn  Asn Tyr Gln Cys Val  Cys Arg Ser 
    1265                 1270                 1275             


Thr Phe  Thr Gly Arg His Cys  Glu Thr Phe Val Asp  Val Cys Pro 
    1280                 1285                 1290             


Gln Lys  Pro Cys Leu Asn Gly  Gly Thr Cys Ala Val  Ala Ser Asn 
    1295                 1300                 1305             


Met Pro  Asp Gly Phe Ile Cys  Arg Cys Pro Pro Gly  Phe Ser Gly 
    1310                 1315                 1320             


Ala Lys  Cys Gln Ser Ser Cys  Gly Gln Val Lys Cys  Arg Lys Gly 
    1325                 1330                 1335             


Glu Gln  Cys Val His Thr Ala  Ala Gly Pro Arg Cys  Phe Cys Pro 
    1340                 1345                 1350             


Ser Pro  Gln Asp Cys Glu Ser  Gly Cys Ala Ser Ser  Pro Cys Gln 
    1355                 1360                 1365             


His Gly  Gly Ser Cys Tyr Pro  Gln Arg Gln Pro Pro  Tyr Tyr Ser 
    1370                 1375                 1380             


Cys His  Cys Ser Val Pro Phe  Gly Gly Asn His Cys  Gln Phe Tyr 
    1385                 1390                 1395             


Met Ala  Pro Thr Ser Ile Pro  Ser Asp Ile Cys Ala  Ser Gln Tyr 
    1400                 1405                 1410             


Cys Ala  Asp Lys Ala Arg Asp  Gly Val Cys Asp Glu  Val Cys Asn 
    1415                 1420                 1425             


Ser His  Ala Cys Gln Trp Asp  Gly Gly Asp Cys Ser  Leu Thr Met 
    1430                 1435                 1440             


Glu Asp  Pro Trp Ala Asn Cys  Ser Ser Pro Leu Pro  Cys Trp Asn 
    1445                 1450                 1455             


Tyr Ile  Asn Asn Gln Cys Asp  Glu Leu Cys Asn Thr  Ala Glu Cys 
    1460                 1465                 1470             


Leu Phe  Asp Asn Phe Glu Cys  Gln Gly Asn Ser Lys  Thr Cys Lys 
    1475                 1480                 1485             


Tyr Asp  Lys Tyr Cys Ala Asp  His Phe Lys Asp Asn  His Cys Asp 
    1490                 1495                 1500             


Gln Gly  Cys Asn Ser Glu Glu  Cys Gly Trp Asp Gly  Leu Asp Cys 
    1505                 1510                 1515             


Ala Ala  Asp Gln Pro Glu Asn  Leu Ala Glu Gly Thr  Leu Val Ile 
    1520                 1525                 1530             


Val Val  Leu Met Pro Pro Glu  Gln Leu Leu Gln Asp  Ala Arg Ser 
    1535                 1540                 1545             


Phe Leu  Arg Ala Leu Gly Thr  Leu Leu His Thr Asn  Leu Arg Ile 
    1550                 1555                 1560             


Lys Leu  Asp Ser Gln Gly Leu  Pro Met Val Tyr Pro  Tyr Tyr Gly 
    1565                 1570                 1575             


Glu Lys  Ser Ala Ala Met Lys  Lys Gln Lys Leu Ser  Arg Arg Ser 
    1580                 1585                 1590             


Leu Pro  Asp Glu Gln Glu Gln  Glu Val Ala Gly Ser  Gln Val Phe 
    1595                 1600                 1605             


Leu Glu  Ile Asp Asn Arg Gln  Cys Val Gln Asp Ser  Glu Gln Cys 
    1610                 1615                 1620             


Phe Lys  Asn Thr Asp Ala Ala  Ala Ala Leu Leu Ala  Ser His Ala 
    1625                 1630                 1635             


Ile Gln  Gly Thr Leu Ser Tyr  Pro Leu Val Ser Val  Val Ser Glu 
    1640                 1645                 1650             


Ser Leu  Ser Pro Lys Pro Thr  Pro Leu Leu Tyr Leu  Leu Ala Val 
    1655                 1660                 1665             


Ala Val  Val Phe Ile Leu Phe  Ile Ile Leu Leu Gly  Val Ile Met 
    1670                 1675                 1680             


Ala Lys  Arg Lys Arg Lys His  Gly Ser Leu Trp Leu  Pro Glu Gly 
    1685                 1690                 1695             


Phe Thr  Leu Arg Arg Asp Ser  Ser Asn His Lys Arg  Arg Glu Pro 
    1700                 1705                 1710             


Val Gly  Gln Asp Ala Val Gly  Leu Lys Asn Leu Ser  Val Gln Val 
    1715                 1720                 1725             


Ser Glu  Ala Asn Leu Ile Gly  Ser Gly Thr Ser Glu  His Trp Val 
    1730                 1735                 1740             


Asp Asp  Glu Gly Pro Gln Pro  Lys Lys Ala Lys Ala  Glu Asp Glu 
    1745                 1750                 1755             


Ala Leu  Leu Ser Glu Glu Glu  Asp Pro Ile Asp Arg  Arg Pro Trp 
    1760                 1765                 1770             


Thr Gln  Gln His Leu Glu Ala  Ala Asp Ile Arg Arg  Thr Pro Ser 
    1775                 1780                 1785             


Leu Ala  Leu Thr Pro Pro Gln  Ala Glu Gln Glu Val  Asp Val Leu 
    1790                 1795                 1800             


Asp Val  Asn Val Arg Gly Pro  Asp Gly Cys Thr Pro  Leu Met Leu 
    1805                 1810                 1815             


Ala Ser  Leu Arg Gly Gly Ser  Ser Asp Met Ser Asp  Glu Asp Glu 
    1820                 1825                 1830             


Asp Gly  Glu Asp Ser Ser Ala  Asn Ile Ile Thr Asp  Leu Val Tyr 
    1835                 1840                 1845             


Gln Gly  Ala Ser Leu Gln Ala  Gln Thr Asp Arg Thr  Gly Glu Met 
    1850                 1855                 1860             


Ala Leu  His Leu Ala Ala Arg  Tyr Ser Arg Ala Asp  Ala Ala Lys 
    1865                 1870                 1875             


Arg Leu  Leu Asp Ala Gly Ala  Asp Ala Asn Ala Gln  Asp Asn Met 
    1880                 1885                 1890             


Gly Arg  Cys Pro Leu His Ala  Ala Val Ala Ala Asp  Ala Gln Gly 
    1895                 1900                 1905             


Val Phe  Gln Ile Leu Ile Arg  Asn Arg Val Thr Asp  Leu Asp Ala 
    1910                 1915                 1920             


Arg Met  Asn Asp Gly Thr Thr  Pro Leu Ile Leu Ala  Ala Arg Leu 
    1925                 1930                 1935             


Ala Val  Glu Gly Met Val Ala  Glu Leu Ile Asn Cys  Gln Ala Asp 
    1940                 1945                 1950             


Val Asn  Ala Val Asp Asp His  Gly Lys Ser Ala Leu  His Trp Ala 
    1955                 1960                 1965             


Ala Ala  Val Asn Asn Val Glu  Ala Thr Leu Leu Leu  Leu Lys Asn 
    1970                 1975                 1980             


Gly Ala  Asn Arg Asp Met Gln  Asp Asn Lys Glu Glu  Thr Pro Leu 
    1985                 1990                 1995             


Phe Leu  Ala Ala Arg Glu Gly  Ser Tyr Glu Ala Ala  Lys Ile Leu 
    2000                 2005                 2010             


Leu Asp  His Phe Ala Asn Arg  Asp Ile Thr Asp His  Met Asp Arg 
    2015                 2020                 2025             


Leu Pro  Arg Asp Val Ala Arg  Asp Arg Met His His  Asp Ile Val 
    2030                 2035                 2040             


Arg Leu  Leu Asp Glu Tyr Asn  Val Thr Pro Ser Pro  Pro Gly Thr 
    2045                 2050                 2055             


Val Leu  Thr Ser Ala Leu Ser  Pro Val Ile Cys Gly  Pro Asn Arg 
    2060                 2065                 2070             


Ser Phe  Leu Ser Leu Lys His  Thr Pro Met Ala Lys  Lys Ser Arg 
    2075                 2080                 2085             


Arg Pro  Asn Ala Lys Ser Thr  Met Pro Thr Ser Leu  Pro Asn Leu 
    2090                 2095                 2100             


Ala Lys  Glu Ala Lys Asp Ala  Lys Gly Ser Arg Arg  Lys Lys Ser 
    2105                 2110                 2115             


Leu Ser  Glu Lys Val Gln Leu  Ser Glu Ser Ser Val  Thr Leu Ser 
    2120                 2125                 2130             


Pro Val  Asp Ser Leu Glu Ser  Pro His Thr Tyr Val  Ser Asp Thr 
    2135                 2140                 2145             


Thr Ser  Ser Pro Met Ile Thr  Ser Pro Gly Ile Leu  Gln Ala Ser 
    2150                 2155                 2160             


Pro Asn  Pro Met Leu Ala Ala  Ala Ala Pro Gln Ala  Pro Val His 
    2165                 2170                 2175             


Ala Gln  His Ala Leu Ser Phe  Pro Asn Pro His Glu  Met Gln Pro 
    2180                 2185                 2190             


Leu Ala  Pro Gly Ala Ser Thr  Val Leu Pro Ser Val  Ser Gln Leu 
    2195                 2200                 2205             


Leu Ser  His His His Ile Val  Pro Pro Gly Ser Ser  Ser Ala Gly 
    2210                 2215                 2220             


Asn Leu  Ser Arg Leu His Pro  Val Thr Val Pro Ala  Asp Trp Met 
    2225                 2230                 2235             


Asn Arg  Met Glu Met Ser Asp  Thr Gln Tyr Asn Glu  Met Phe Gly 
    2240                 2245                 2250             


Met Val  Leu Thr Pro Ala Glu  Gly Thr His Pro Gly  Ile Ala Pro 
    2255                 2260                 2265             


Gln Ser  Arg Pro Pro Glu Gly  Lys His Val Pro Thr  Pro Arg Glu 
    2270                 2275                 2280             


Thr Leu  Pro Pro Ile Val Thr  Phe Gln Leu Ile Pro  Lys Gly Ser 
    2285                 2290                 2295             


Ile Ala  Gln Pro Ala Gly Ala  Ser Gln Pro Gln Ser  Thr Cys Pro 
    2300                 2305                 2310             


Pro Ala  Val Ala Gly Pro Leu  Pro Thr Met Tyr Gln  Ile Pro Glu 
    2315                 2320                 2325             


Met Ala  Arg Leu Pro Gly Val  Ala Phe Pro Thr Ala  Met Met Pro 
    2330                 2335                 2340             


Gln Gln  Asp Gly Gln Val Ala  Gln Thr Ile Leu Pro  Ala Tyr His 
    2345                 2350                 2355             


Pro Phe  Pro Ala Ser Val Gly  Lys Tyr Pro Thr Pro  Pro Ser Gln 
    2360                 2365                 2370             


His Ser  Tyr Ala Ser Ser Asn  Ala Ala Glu Arg Thr  Pro Asn His 
    2375                 2380                 2385             


Ser Gly  His Leu Gln Gly Glu  His Pro Tyr Leu Thr  Pro Ser Pro 
    2390                 2395                 2400             


Asp Ser  Pro Asp Gln Trp Ser  Ser Ser Ser Pro His  Ser Ala Ser 
    2405                 2410                 2415             


Asp Trp  Ser Asp Val Thr Thr  Ser Pro Thr Pro Gly  Ser Gly Gly 
    2420                 2425                 2430             


Gly Gly  Gln Arg Gly Pro Gly  Thr His Met Ser Glu  Pro Pro His 
    2435                 2440                 2445             


Ser Asn  Met Gln Val Tyr Ala  
    2450                 2455 


<210>  73
<211>  2473
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(2473)
<223>  Mouse Notch2, with signal sequence (amino acids 1-25)

<400>  73

Met Pro Ala Leu Arg Pro Ala Ala Leu Arg Ala Leu Leu Trp Leu Trp 
1               5                   10                  15      


Leu Cys Gly Ala Gly Pro Ala His Ala Leu Gln Cys Arg Gly Gly Gln 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Thr Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Phe Cys Arg Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Pro Gln Gly Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Pro Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Gln Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Gln Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Glu Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Ser Val Ala Ser Gln Phe Ser Cys Lys Cys Pro Ala Gly Leu Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Ala Asp Ile Asn Glu Cys Asp Ile Pro Gly Arg Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Arg Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln His Cys Asp Ser Pro Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Lys Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Thr Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Tyr Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Leu Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Val Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Ile Leu Cys Asp Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Leu 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Met His 
                645                 650                 655     


Gly Val Cys Val Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Asp Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Val 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asn Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Val Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Met Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ala Pro Asn Phe Glu Ser Phe Ser Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Lys Arg Cys Thr Val Asp Val Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn Asn Gly Val Cys His Asn Thr Gln Gly Ser Tyr Val 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asn Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp 
        915                 920                 925             


His Val Asn Thr Phe Ser Cys Gln Cys His Pro Gly Phe Ile Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Thr Cys Pro 
                965                 970                 975     


Ala Gly Phe His Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Pro  Phe Cys Leu 
    1010                 1015                 1020             


His Asp  Ile Asn Glu Cys Ser  Ser Asn Pro Cys Leu  Asn Ala Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ile  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Glu Lys Ala 
    1070                 1075                 1080             


Arg Pro  His Cys Leu Cys Pro  Pro Gly Trp Asp Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Leu Asn Val Ser Cys  Lys Ala Ala Ala Leu  Gln Lys Gly 
    1100                 1105                 1110             


Val Pro  Val Glu His Leu Cys  Gln His Ser Gly Ile  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His His Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Asn  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Glu Cys Ala  Gly Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Val Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Thr Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Val Gln Leu Lys  Asn Asn Tyr Asn Cys  Ile Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Leu  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Lys Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Arg 
    1340                 1345                 1350             


Gly Glu  Gln Cys Ile His Thr  Asp Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Leu Asn  Pro Lys Asp Cys Glu  Ser Gly Cys Ala Ser  Asn Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Thr Cys Tyr  Pro Gln Arg Gln Pro  Pro His Tyr 
    1385                 1390                 1395             


Ser Cys  Arg Cys Pro Pro Ser  Phe Gly Gly Ser His  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Thr Ser Thr  Pro Pro Ala Thr Cys  Gln Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Ile Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asp Pro Trp Ala Asn  Cys Thr Ser Thr Leu  Arg Cys Trp 
    1460                 1465                 1470             


Glu Tyr  Ile Asn Asn Gln Cys  Asp Glu Gln Cys Asn  Thr Ala Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Arg Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ser Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Ile 
    1535                 1540                 1545             


Ile Val  Val Leu Leu Pro Pro  Glu Gln Leu Leu Gln  Asp Ser Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Gln Asp Ser Gln Gly  Ala Leu Met Val Tyr  Pro Tyr Phe 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Lys Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Glu Glu Gln Glu  Gln Glu Gln Glu Val  Ile Gly Ser 
    1610                 1615                 1620             


Lys Ile  Phe Leu Glu Ile Asp  Asn Arg Gln Cys Val  Gln Asp Ser 
    1625                 1630                 1635             


Asp Gln  Cys Phe Lys Asn Thr  Asp Ala Ala Ala Ala  Leu Leu Ala 
    1640                 1645                 1650             


Ser His  Ala Ile Gln Gly Thr  Leu Ser Tyr Pro Leu  Val Ser Val 
    1655                 1660                 1665             


Phe Ser  Glu Leu Glu Ser Pro  Arg Asn Ala Gln Leu  Leu Tyr Leu 
    1670                 1675                 1680             


Leu Ala  Val Ala Val Val Ile  Ile Leu Phe Phe Ile  Leu Leu Gly 
    1685                 1690                 1695             


Val Ile  Met Ala Lys Arg Lys  Arg Lys His Gly Phe  Leu Trp Leu 
    1700                 1705                 1710             


Pro Glu  Gly Phe Thr Leu Arg  Arg Asp Ser Ser Asn  His Lys Arg 
    1715                 1720                 1725             


Arg Glu  Pro Val Gly Gln Asp  Ala Val Gly Leu Lys  Asn Leu Ser 
    1730                 1735                 1740             


Val Gln  Val Ser Glu Ala Asn  Leu Ile Gly Ser Gly  Thr Ser Glu 
    1745                 1750                 1755             


His Trp  Val Asp Asp Glu Gly  Pro Gln Pro Lys Lys  Ala Lys Ala 
    1760                 1765                 1770             


Glu Asp  Glu Ala Leu Leu Ser  Glu Asp Asp Pro Ile  Asp Arg Arg 
    1775                 1780                 1785             


Pro Trp  Thr Gln Gln His Leu  Glu Ala Ala Asp Ile  Arg His Thr 
    1790                 1795                 1800             


Pro Ser  Leu Ala Leu Thr Pro  Pro Gln Ala Glu Gln  Glu Val Asp 
    1805                 1810                 1815             


Val Leu  Asp Val Asn Val Arg  Gly Pro Asp Gly Cys  Thr Pro Leu 
    1820                 1825                 1830             


Met Leu  Ala Ser Leu Arg Gly  Gly Ser Ser Asp Leu  Ser Asp Glu 
    1835                 1840                 1845             


Asp Glu  Asp Ala Glu Asp Ser  Ser Ala Asn Ile Ile  Thr Asp Leu 
    1850                 1855                 1860             


Val Tyr  Gln Gly Ala Ser Leu  Gln Ala Gln Thr Asp  Arg Thr Gly 
    1865                 1870                 1875             


Glu Met  Ala Leu His Leu Ala  Ala Arg Tyr Ser Arg  Ala Asp Ala 
    1880                 1885                 1890             


Ala Lys  Arg Leu Leu Asp Ala  Gly Ala Asp Ala Asn  Ala Gln Asp 
    1895                 1900                 1905             


Asn Met  Gly Arg Cys Pro Leu  His Ala Ala Val Ala  Ala Asp Ala 
    1910                 1915                 1920             


Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn Arg Val  Thr Asp Leu 
    1925                 1930                 1935             


Asp Ala  Arg Met Asn Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala 
    1940                 1945                 1950             


Arg Leu  Ala Val Glu Gly Met  Val Ala Glu Leu Ile  Asn Cys Gln 
    1955                 1960                 1965             


Ala Asp  Val Asn Ala Val Asp  Asp His Gly Lys Ser  Ala Leu His 
    1970                 1975                 1980             


Trp Ala  Ala Ala Val Asn Asn  Val Glu Ala Thr Leu  Leu Leu Leu 
    1985                 1990                 1995             


Lys Asn  Gly Ala Asn Arg Asp  Met Gln Asp Asn Lys  Glu Glu Thr 
    2000                 2005                 2010             


Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser Tyr Glu  Ala Ala Lys 
    2015                 2020                 2025             


Ile Leu  Leu Asp His Phe Ala  Asn Arg Asp Ile Thr  Asp His Met 
    2030                 2035                 2040             


Asp Arg  Leu Pro Arg Asp Val  Ala Arg Asp Arg Met  His His Asp 
    2045                 2050                 2055             


Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Val Thr Pro  Ser Pro Pro 
    2060                 2065                 2070             


Gly Thr  Val Leu Thr Ser Ala  Leu Ser Pro Val Leu  Cys Gly Pro 
    2075                 2080                 2085             


Asn Arg  Ser Phe Leu Ser Leu  Lys His Thr Pro Met  Gly Lys Lys 
    2090                 2095                 2100             


Ala Arg  Arg Pro Asn Thr Lys  Ser Thr Met Pro Thr  Ser Leu Pro 
    2105                 2110                 2115             


Asn Leu  Ala Lys Glu Ala Lys  Asp Ala Lys Gly Ser  Arg Arg Lys 
    2120                 2125                 2130             


Lys Cys  Leu Asn Glu Lys Val  Gln Leu Ser Glu Ser  Ser Val Thr 
    2135                 2140                 2145             


Leu Ser  Pro Val Asp Ser Leu  Glu Ser Pro His Thr  Tyr Val Ser 
    2150                 2155                 2160             


Asp Ala  Thr Ser Ser Pro Met  Ile Thr Ser Pro Gly  Ile Leu Gln 
    2165                 2170                 2175             


Ala Ser  Pro Thr Pro Leu Leu  Ala Ala Ala Ala Pro  Ala Ala Pro 
    2180                 2185                 2190             


Val His  Thr Gln His Ala Leu  Ser Phe Ser Asn Leu  His Asp Met 
    2195                 2200                 2205             


Gln Pro  Leu Ala Pro Gly Ala  Ser Thr Val Leu Pro  Ser Val Ser 
    2210                 2215                 2220             


Gln Leu  Leu Ser His His His  Ile Ala Pro Pro Gly  Ser Ser Ser 
    2225                 2230                 2235             


Ala Gly  Ser Leu Gly Arg Leu  His Pro Val Pro Val  Pro Ala Asp 
    2240                 2245                 2250             


Trp Met  Asn Arg Val Glu Met  Asn Glu Thr Gln Tyr  Ser Glu Met 
    2255                 2260                 2265             


Phe Gly  Met Val Leu Ala Pro  Ala Glu Gly Ala His  Pro Gly Ile 
    2270                 2275                 2280             


Ala Ala  Pro Gln Ser Arg Pro  Pro Glu Gly Lys His  Met Ser Thr 
    2285                 2290                 2295             


Gln Arg  Glu Pro Leu Pro Pro  Ile Val Thr Phe Gln  Leu Ile Pro 
    2300                 2305                 2310             


Lys Gly  Ser Ile Ala Gln Ala  Ala Gly Ala Pro Gln  Thr Gln Ser 
    2315                 2320                 2325             


Ser Cys  Pro Pro Ala Val Ala  Gly Pro Leu Pro Ser  Met Tyr Gln 
    2330                 2335                 2340             


Ile Pro  Glu Met Pro Arg Leu  Pro Ser Val Ala Phe  Pro Pro Thr 
    2345                 2350                 2355             


Met Met  Pro Gln Gln Glu Gly  Gln Val Ala Gln Thr  Ile Val Pro 
    2360                 2365                 2370             


Thr Tyr  His Pro Phe Pro Ala  Ser Val Gly Lys Tyr  Pro Thr Pro 
    2375                 2380                 2385             


Pro Ser  Gln His Ser Tyr Ala  Ser Ser Asn Ala Ala  Glu Arg Thr 
    2390                 2395                 2400             


Pro Ser  His Gly Gly His Leu  Gln Gly Glu His Pro  Tyr Leu Thr 
    2405                 2410                 2415             


Pro Ser  Pro Glu Ser Pro Asp  Gln Trp Ser Ser Ser  Ser Pro His 
    2420                 2425                 2430             


Ser Ala  Ser Asp Trp Ser Asp  Val Thr Thr Ser Pro  Thr Pro Gly 
    2435                 2440                 2445             


Gly Gly  Gly Gly Gly Gln Arg  Gly Pro Gly Thr His  Met Ser Glu 
    2450                 2455                 2460             


Pro Pro  His Ser Asn Met Gln  Val Tyr Ala 
    2465                 2470             


<210>  74
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch2-EGF6-10

<400>  74

Ala Gly Ser Asp Ser Leu Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn 
            20                  25                  30          


Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Asn His Arg Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys Ala Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Ser Cys Met Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys Gly Ala Leu Cys Asp 
                165                 170                 175     


Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr Cys Pro Gln Gly Tyr 
            180                 185                 190         


Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu Gly Asn Ser His His 
        195                 200                 205             


His His His His 
    210         


<210>  75
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: muNotch2-EGF6-10

<400>  75

Ala Gly Ser Asp Ser Pro Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn 
            20                  25                  30          


Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Asn His Lys Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys Thr Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Tyr Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Ser Cys Leu Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys Gly Ala Leu Cys Asp 
                165                 170                 175     


Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr Cys Pro Gln Gly Tyr 
            180                 185                 190         


Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu Gly Asn Ser Gly Leu 
        195                 200                 205             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly His His His His His His His His 
225                 230                 235 


<210>  76
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: gpNotch2-EGF6-12

<400>  76

Ala Gly Ser Asp Asn Pro Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Ser 
            20                  25                  30          


Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Asn His Arg Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys Thr Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Ser Cys Met Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys Gly Ala Leu Cys Asp 
                165                 170                 175     


Thr Asn Pro Leu Asn Gly His Tyr Ile Cys Thr Cys Pro Gln Gly Tyr 
            180                 185                 190         


Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu Cys Ala Met Thr Asn 
        195                 200                 205             


Ser Asn Pro Cys Glu His Ala Gly Lys Cys Val Asn Thr Asp Gly Ala 
    210                 215                 220                 


Phe His Cys Glu Cys Leu Lys Gly Tyr Ala Gly Pro Arg Cys Glu Met 
225                 230                 235                 240 


Asp Ile Asn Glu Cys His Ser Asp Pro Cys Gln Asn Asp Ala Thr Cys 
                245                 250                 255     


Leu Asp Lys Ile Gly Gly Phe Thr Cys Leu Cys Met Pro Gly Phe Lys 
            260                 265                 270         


Gly Val His Cys Glu Ile Glu Ile Asn Glu Gly Asn Ser Gly Leu Asn 
        275                 280                 285             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asn Leu Tyr Phe 
    290                 295                 300                 


Gln Gly His His His His His His His His 
305                 310                 


<210>  77
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch2-EGF6-12.R268K

<400>  77

Ala Gly Ser Asp Ser Leu Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn 
            20                  25                  30          


Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Asn His Lys Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys Ala Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Ser Cys Met Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys Gly Ala Leu Cys Asp 
                165                 170                 175     


Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr Cys Pro Gln Gly Tyr 
            180                 185                 190         


Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu Cys Ala Met Ala Asn 
        195                 200                 205             


Ser Asn Pro Cys Glu His Ala Gly Lys Cys Val Asn Thr Asp Gly Ala 
    210                 215                 220                 


Phe His Cys Glu Cys Leu Lys Gly Tyr Ala Gly Pro Arg Cys Glu Met 
225                 230                 235                 240 


Asp Ile Asn Glu Cys His Ser Asp Pro Cys Gln Asn Asp Ala Thr Cys 
                245                 250                 255     


Leu Asp Lys Ile Gly Gly Phe Thr Cys Leu Cys Met Pro Gly Phe Lys 
            260                 265                 270         


Gly Val His Cys Glu Gly Asn Ser Gly Leu Asn Asp Ile Phe Glu Ala 
        275                 280                 285             


Gln Lys Ile Glu Trp His Glu Asn Leu Tyr Phe Gln Gly His His His 
    290                 295                 300                 


His His His His His 
305                 


<210>  78
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: muNotch2-EGF6-12.K268R

<400>  78

Ala Gly Ser Asp Ser Pro Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn 
            20                  25                  30          


Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Asn His Arg Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys Thr Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Tyr Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Ser Cys Leu Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys Gly Ala Leu Cys Asp 
                165                 170                 175     


Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr Cys Pro Gln Gly Tyr 
            180                 185                 190         


Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu Cys Ala Met Ala Asn 
        195                 200                 205             


Ser Asn Pro Cys Glu His Ala Gly Lys Cys Val Asn Thr Asp Gly Ala 
    210                 215                 220                 


Phe His Cys Glu Cys Leu Lys Gly Tyr Ala Gly Pro Arg Cys Glu Met 
225                 230                 235                 240 


Asp Ile Asn Glu Cys His Ser Asp Pro Cys Gln Asn Asp Ala Thr Cys 
                245                 250                 255     


Leu Asp Lys Ile Gly Gly Phe Thr Cys Leu Cys Met Pro Gly Phe Lys 
            260                 265                 270         


Gly Val His Cys Glu Leu Glu Val Asn Glu Gly Asn Ser Gly Leu Asn 
        275                 280                 285             


Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asn Leu Tyr Phe 
    290                 295                 300                 


Gln Gly His His His His His His His His 
305                 310                 


<210>  79
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: ratNotch2-EGF6-10

<400>  79

Ala Gly Ser Asp Ser Pro Tyr Val Pro Cys Ala Pro Ser Pro Cys Val 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp Phe Thr Ser Glu Cys His 
            20                  25                  30          


Cys Leu Pro Gly Phe Glu Gly Ser Asn Cys Glu Arg Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Asn His Lys Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys Thr Asn Arg Asn Gly Gly Tyr Gly Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Ser Cys Leu Cys Pro Glu Gly Lys Ala Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys Gly Ala Leu Cys Asp 
                165                 170                 175     


Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr Cys Pro Gln Ala Tyr 
            180                 185                 190         


Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu Gly Asn Ser Gly Leu 
        195                 200                 205             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly His His His His His His His His 
225                 230                 235 


<210>  80
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: muNotch2 EGF7 (amino acids 260-296)

<400>  80

Asn Ile Asp Asp Cys Pro Asn His Lys Cys Gln Asn Gly Gly Val Cys 
1               5                   10                  15      


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln Trp Thr 
            20                  25                  30          


Gly Gln Phe Cys Thr 
        35          


<210>  81
<211>  2471
<212>  PRT
<213>  Rattus sp.


<220>
<221>  misc_feature
<222>  (1)..(2471)
<223>  Rat Notch2, with signal sequence (amino acids 1-25)

<400>  81

Met Pro Ala Leu Arg Pro Ala Ala Leu Arg Ala Leu Leu Trp Leu Trp 
1               5                   10                  15      


Leu Cys Gly Ala Gly Pro Ala His Ala Leu Gln Cys Arg Gly Gly Gln 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Thr Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Arg Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Thr Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Pro Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Gln Asn Gly Gly Thr Cys His Met Leu Ser Trp Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Gln Cys Gln Trp 
    130                 135                 140                 


Thr Asp Val Cys Leu Ser His Pro Cys Glu Asn Gly Ser Thr Cys Ser 
145                 150                 155                 160 


Ser Val Ala Asn Gln Phe Ser Cys Arg Cys Pro Ala Gly Ile Thr Gly 
                165                 170                 175     


Gln Lys Cys Asp Ala Asp Ile Asn Glu Cys Asp Ile Pro Gly Arg Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Arg Cys Gln 
        195                 200                 205             


Cys Pro Gln Arg Phe Thr Gly Gln His Cys Asp Ser Pro Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Ser Glu Cys His Cys Leu Pro Gly Phe Glu Gly Ser Asn 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Lys Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Thr Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Leu Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Ala Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Val Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Thr Leu Cys Asp Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Leu 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Leu His 
                645                 650                 655     


Gly Ala Cys Val Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Asp Ala Thr Cys Ile Asn Asp Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Met Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Ser Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asn Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Leu Asp Asp Val Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Met Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ala Pro Asn Phe Glu Ser Phe Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Val Asp Val Asp Glu Cys Val Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn Asn Gly Ile Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asn Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Val Asp 
        915                 920                 925             


Lys Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Val Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Thr Cys Pro 
                965                 970                 975     


Ala Gly Phe His Gly Val His Cys Glu Asn Asn Ile Asp Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Pro  Phe Cys Leu 
    1010                 1015                 1020             


His Asp  Ile Asn Glu Cys Ser  Ser Asn Pro Cys Leu  Asn Ser Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Thr  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Pro Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Ala Gln  Glu Lys Ala 
    1070                 1075                 1080             


Arg Pro  Arg Cys Leu Cys Pro  Pro Gly Trp Asp Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Leu Asn Val Ser Cys  Lys Ala Ala Ala Leu  Gln Lys Gly 
    1100                 1105                 1110             


Val Pro  Val Glu His Leu Cys  Gln His Ser Gly Ile  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His His Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Gly Ala Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Val Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Lys  Asn Asn Tyr Gln Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Leu  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Lys Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Val  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Arg 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro His  Cys Phe Cys 
    1355                 1360                 1365             


Pro Asn  His Lys Asp Cys Glu  Ser Gly Cys Ala Ser  Asn Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Thr Cys Tyr  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Arg Cys Ser Pro Pro  Phe Trp Gly Ser His  Cys Glu Ser 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Thr Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Ile Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asp Pro Trp Ala Asn  Cys Thr Ser Ser Leu  Arg Cys Trp 
    1460                 1465                 1470             


Glu Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Ala Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Arg Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Lys  Gly Cys Asn Asn Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Ile Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Leu Pro Pro  Glu Gln Leu Leu Gln  Asp Ser Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Gln Asp Ser Gln Gly  Ala Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Lys Val  Ala Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Asp Glu Gln Glu  Gln Glu Ile Ile Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp Gln 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Glu Asp Pro Arg Asn  Thr Pro Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Leu Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Phe Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ser Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Ser Thr Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Gly Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Ala Lys  Ala Glu Asp 
    1760                 1765                 1770             


Asp Glu  Ala Leu Leu Ser Glu  Asp Asp Pro Val Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Leu Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ala 
    2090                 2095                 2100             


Arg Arg  Pro Asn Thr Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Val Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Cys Leu  Asn Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Ala Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Thr Pro Leu Leu Ala  Ala Ala Pro Ala Ala  Pro Val His 
    2180                 2185                 2190             


Ala Gln  His Ala Leu Ser Phe  Ser Asn Leu His Glu  Met Gln Pro 
    2195                 2200                 2205             


Leu Arg  Pro Gly Ala Ser Thr  Val Leu Pro Ser Val  Ser Gln Leu 
    2210                 2215                 2220             


Leu Ser  His His His Ile Val  Pro Pro Gly Ser Gly  Ser Ala Gly 
    2225                 2230                 2235             


Ser Leu  Gly Arg Leu His Ser  Val Pro Val Pro Ser  Asp Trp Met 
    2240                 2245                 2250             


Asn Arg  Val Glu Met Ser Glu  Thr Gln Tyr Ser Glu  Met Phe Gly 
    2255                 2260                 2265             


Met Val  Leu Ala Pro Ala Glu  Gly Thr His Pro Gly  Met Ala Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Ala Pro Glu  Gly Lys Pro Ile Pro  Thr Gln Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Leu  Ala Gln Ala Ala Gly  Ala Pro Gln Thr Gln  Ser Gly Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Ser Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Pro  Thr Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Glu Gly Gln Val  Ala Gln Thr Ile Val  Pro Thr Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Asn 
    2390                 2395                 2400             


His Gly  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Gly 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Ser  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  82
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch2-EGF4-7

<400>  82

Gly Ser Gln Trp Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly 
1               5                   10                  15      


Ser Thr Cys Thr Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr 
            20                  25                  30          


Gly Phe Thr Gly Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile 
        35                  40                  45              


Pro Gly His Cys Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser 
    50                  55                  60                  


Tyr Gln Cys Gln Cys Leu Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser 
65                  70                  75                  80  


Leu Tyr Val Pro Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys 
                85                  90                  95      


Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe 
            100                 105                 110         


Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg 
        115                 120                 125             


Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys 
    130                 135                 140                 


Arg Cys Pro Pro Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp 
145                 150                 155                 160 


Glu Gly Asn Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
                165                 170                 175     


Trp His Glu Asn Leu Tyr Phe Gln Gly His His His His His His His 
            180                 185                 190         


His 
    


<210>  83
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch2-EGF5-8

<400>  83

Gly Ser Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys Gln 
1               5                   10                  15      


His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln Cys 
            20                  25                  30          


Leu Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro Cys 
        35                  40                  45              


Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly Asp 
    50                  55                  60                  


Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr Cys 
65                  70                  75                  80  


Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly Gly 
                85                  90                  95      


Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln 
            100                 105                 110         


Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu Gln 
        115                 120                 125             


Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly Gly 
    130                 135                 140                 


Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu 
145                 150                 155                 160 


Asn Ile Asp Asp Gly Asn Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                165                 170                 175     


Lys Ile Glu Trp His Glu Asn Leu Tyr Phe Gln Gly His His His His 
            180                 185                 190         


His His His His 
        195     


<210>  84
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch2-EGF7-9

<400>  84

Ala His His His His His His Gly Glu Asn Leu Tyr Phe Gln Gly Ser 
1               5                   10                  15      


Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly Gly 
            20                  25                  30          


Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Gln 
        35                  40                  45              


Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu Gln 
    50                  55                  60                  


Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly Gly 
65                  70                  75                  80  


Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu 
                85                  90                  95      


Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys 
            100                 105                 110         


Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys Ala 
        115                 120                 125             


Gly Leu Leu Cys His Leu Asp Asp Ala Gly Asn Ser 
    130                 135                 140 


<210>  85
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch1

<400>  85

Ala Gly Ser Glu Arg Pro Tyr Val Pro Cys Ser Pro Ser Pro Cys Gln 
1               5                   10                  15      


Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr His Glu Cys Ala 
            20                  25                  30          


Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu Asn Ile Asp Asp 
        35                  40                  45              


Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys Val Asp Gly Val 
    50                  55                  60                  


Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr Gly Gln Tyr Cys 
65                  70                  75                  80  


Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn Ala Cys Gln Asn 
                85                  90                  95      


Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn Cys Val Cys Val 
            100                 105                 110         


Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala 
        115                 120                 125             


Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser 
    130                 135                 140                 


Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu Leu Cys His Leu 
145                 150                 155                 160 


Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly Ser Asn Cys Asp 
                165                 170                 175     


Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys Pro Ser Gly Tyr 
            180                 185                 190         


Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Gly Asn Ser Gly Leu 
        195                 200                 205             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asn Leu Tyr 
    210                 215                 220                 


Phe Gln Gly His His His His His His His His 
225                 230                 235 


<210>  86
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: huNotch3

<400>  86

Gly Ser Glu Asn Pro Ala Val Pro Cys Ala Pro Ser Pro Cys Arg Asn 
1               5                   10                  15      


Gly Gly Thr Cys Arg Gln Ser Gly Asp Leu Thr Tyr Asp Cys Ala Cys 
            20                  25                  30          


Leu Pro Gly Phe Glu Gly Gln Asn Cys Glu Val Asn Val Asp Asp Cys 
        35                  40                  45              


Pro Gly His Arg Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asn 
    50                  55                  60                  


Thr Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Phe Cys Thr 
65                  70                  75                  80  


Glu Asp Val Asp Glu Cys Gln Leu Gln Pro Asn Ala Cys His Asn Gly 
                85                  90                  95      


Gly Thr Cys Phe Asn Thr Leu Gly Gly His Ser Cys Val Cys Val Asn 
            100                 105                 110         


Gly Trp Thr Gly Glu Ser Cys Ser Gln Asn Ile Asp Asp Cys Ala Thr 
        115                 120                 125             


Ala Val Cys Phe His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe 
    130                 135                 140                 


Tyr Cys Ala Cys Pro Met Gly Lys Thr Gly Leu Leu Cys His Leu Asp 
145                 150                 155                 160 


Asp Ala Cys Val Ser Asn Pro Cys His Glu Asp Ala Ile Cys Asp Thr 
                165                 170                 175     


Asn Pro Val Asn Gly Arg Ala Ile Cys Thr Cys Pro Pro Gly Phe Thr 
            180                 185                 190         


Gly Gly Ala Cys Asp Gln Asp Val Asp Glu Cys Ser Ile Gly Ala Asn 
        195                 200                 205             


Pro Cys Glu His Leu Gly Arg Cys Val Asn Thr Gln Gly Ser Phe Leu 
    210                 215                 220                 


Cys Gln Cys Gly Arg Gly Tyr Thr Gly Pro Arg Cys Glu Thr Asp Val 
225                 230                 235                 240 


Asn Glu Cys Leu Ser Gly Pro Cys Arg Asn Gln Ala Thr Cys Leu Asp 
                245                 250                 255     


Arg Ile Gly Gln Phe Thr Cys Ile Cys Met Ala Gly Phe Thr Gly Thr 
            260                 265                 270         


Tyr Cys Glu Val Asp Ile Asp Glu Gly Asn Ser Gly Leu Asn Asp Ile 
        275                 280                 285             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asn Leu Tyr Phe Gln Gly 
    290                 295                 300                 


His His His His His His His His 
305                 310         


<210>  87
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LC-FR1 of hu1B2.L1, hu1B2.L7, hu.1B2.v101, 
       hu.1B2.v102, hu.1B2.v103, hu.1B2.v104

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LC-FR2 of hu1B2.L1, hu1B2.L7, hu.1B2.v101, 
       hu.1B2.v102, hu.1B2.v103, hu.1B2.v104

<400>  88

Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  89
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LC-FR3 of hu1B2.L1

<400>  89

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  90
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LC-FR3 of hu1B2.L7, hu.1B2.v101, hu.1B2.v102, 
       hu.1B2.v103, hu.1B2.v104

<400>  90

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: LC-FR4 of hu1B2.L1, hu1B2.L7, hu.1B2.v101, 
       hu.1B2.v102, hu.1B2.v103, hu.1B2.v104

<400>  91

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  92
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR1 of hu.1B2.v1.DFS.H1, hu.1B2.H10, 
       hu.1B2.DFS.H14, hu.1B2.H1.N54D.S51Q, hu.1B2.v2, hu.1B2.v4, 
       hu.1B2.v8, hu.1B2.v9, hu1B2.v101, hu1B2.v102, hu1B2.v103, 
       hu1B2.v104

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  93
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR2 of hu.1B2.v1.DFS.H1, hu.1B2.H1.N54D.S51Q, 
       hu.1B2.v2, hu.1B2.v4, hu.1B2.v8, hu.1B2.v9,

<400>  93

Trp Ile Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR2 of hu.1B2.H10, hu.1B2.DFS.H14, hu1B2.v101, 
       hu1B2.v102, hu1B2.v103, hu1B2.v104

<400>  94

Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  95
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR3 of hu.1B2.v1.DFS.H1, hu.1B2.H1.N54D.S51Q, 
       hu.1B2.v2, hu.1B2.v4, hu.1B2.v8, hu.1B2.v9

<400>  95

Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Ser Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
            20                  25                  30          


<210>  96
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR3 of hu.1B2.DFS.H14, hu1B2.v101, hu1B2.v102, 
       hu1B2.v103, hu1B2.v104

<400>  96

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
            20                  25                  30          


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR4 of hu.1B2.v1.DFS.H1, hu.1B2.H10, 
       hu.1B2.DFS.H14, hu.1B2.H1.N54D.S51Q, hu.1B2.v2, hu.1B2.v4, 
       hu.1B2.v8, hu.1B2.v9, hu1B2.v101, hu1B2.v102, hu1B2.v103, 
       hu1B2.v104

<400>  97

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  98
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.L1 VL

<400>  98

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Ser 
                85                  90                  95      


Thr His Phe Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  99
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.L6 VL

<400>  99

Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Phe Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser 
                85                  90                  95      


Thr His Phe Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  100
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.L7 VL

<400>  100

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser 
                85                  90                  95      


Thr His Phe Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  101
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.V1-2.H1 VH

<400>  101

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Ile Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  102
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.H12 VH

<400>  102

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ser Thr Val Asp Thr Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  103
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.H13 VH

<400>  103

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ser Thr Val Asp Thr Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Val Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  104
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.V5-51.H1 VH

<400>  104

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Ile Arg Gln Met Pro Gly Lys Gly Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Ser Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  105
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.H14 VH

<400>  105

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Ile Ser Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  106
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hu.3107.H15 VH

<400>  106

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Pro Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ile Pro Gly Ser Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Gly Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  107
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: HC-FR3 of hu.1B2.H10

<400>  107

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
            20                  25                  30          


