                         SEQUENCE LISTING

<110>  PhamaIN Corporation
 
<120>  V1A RECEPTOR PARTIAL AGONIST AND METHOD OF USE

<130>  3097-P27WO

<150>  US 63/053,340
<151>  2020-07-17

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X at position 8 is defined as any one of L-Lysine, 
       D-Lysine, L-Ornithine, D-Ornithine, L-Diaminobutyric acid, 
       D-Diaminobutyric acid, L-Diaminopimelic acid , or 
       D-Diaminopimelic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as an amino acid residue 
       selected from Gly, L-Ala, D-Ala, L-Lys, D-Lys, L-Orn, D-Orn, 
       L-Glu, D-Glu, L-Asp, and D-Asp, or a moiety derived from a 
       non-alpha primary amino group-containing C3-12 fatty acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of the amino acid
       residue which is an integer from 0 to 10, or a number of the 
       moiety which is an integer from 1 to 3

<400>  1

Xaa Tyr Phe Xaa Asn Cys Pro Xaa Xaa Xaa Gly 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X at position 8 is defined as any one of L-Lysine, 
       D-Lysine, L-Ornithine, D-Ornithine, L-Diaminobutyric acid, 
       D-Diaminobutyric acid, L-Diaminopimelic acid, or D-Diaminopimelic
       acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as an amino acid residue 
       selected from Gly, L-Ala, D-Ala, L-Lys, D-Lys, L-Orn, D-Orn, 
       L-Glu, D-Glu, L-Asp, and D-Asp, or a moiety derived from a 
       non-alpha primary amino group-containing C3-12 fatty acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of the amino acid
       residue which is an integer from 6 to 10, or a number of the 
       moiety which is an integer from 1 to 3

<400>  2

Xaa Tyr Phe Gln Asn Cys Pro Xaa Xaa Xaa Gly 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as an amino acid residue 
       selected from Gly, L-Ala, D-Ala, L-Lys, D-Lys, L-Orn, D-Orn, 
       L-Glu, D-Glu, L-Asp, and D-Asp

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein X at position 2 is defined as a number of the amino acid 
       residue which is an integer from 0 to 10

<400>  3

Xaa Xaa Cys Tyr Phe Gln Asn Cys Pro Lys Gly 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as an amino acid residue 
       selected from Gly, D-Ala, L-Ala, D-Lys, L-Lys, D-Orn, L-Orn, 
       D-Glu, D-Glu, D-Asp,and L-Asp

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of the amino acid
       residue which is an integer from 0 to 5

<400>  4

Xaa Tyr Phe Gln Asn Cys Pro Lys Xaa Xaa Gly 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of Lysine which 
       is 0, 3, 6, or 9

<400>  5

Xaa Tyr Phe Xaa Asn Cys Pro Lys Lys Xaa Gly 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of Glycine which 
       is 6 or 9

<400>  6

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly Xaa Gly 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as an amino acid residue 
       selected from Gly, L-Ala, D-Ala, L-Lys, D-Lys, L-Orn, D-Orn, 
       L-Glu, D-Glu, L-Asp, and D-Asp

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein X at position 2 is defined as a number of the amino acid 
       residue which is an integer from 0 to 10

<400>  7

Xaa Xaa Cys Tyr Phe Gln Asn Cys Pro Lys Gly 
1               5                   10      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hga)

<400>  8

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly 
1               5                   10  


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hga)

<400>  9

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly 
1               5                   10      


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is mercaptopropionic acid (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is homoglutamine (Hgn)

<400>  10

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly 
1               5                   10          


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<400>  11

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly Gly 
1               5                   10              


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<400>  12

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly 
1               5                   10                  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 1 is defined as homoglutamine (Hgn)

<400>  13

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15  


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is mercaptopropionic acid (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 1 is homoglutamine (Hgn)

<400>  14

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<400>  15

Xaa Tyr Phe Xaa Asn Cys Tyr Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<400>  16

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X at position 8 is defined as diaminopimelic acid (Dap)

<400>  17

Xaa Tyr Phe Xaa Asn Cys Pro Xaa Gly 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X at position 8 is defined as d-Lysine (d-Lys)

<400>  18

Xaa Tyr Phe Xaa Asn Cys Pro Xaa Gly 
1               5                   


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as 12-aminododecanoic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of 
       12-aminododecanoic acid with an integer of 1

<400>  19

Xaa Tyr Phe Xaa Asn Cys Pro Lys Xaa Xaa Gly 
1               5                   10      


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<400>  20

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15  


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<400>  21

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<400>  22

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<400>  23

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as a residue selected from Gly
       and a D- or L- amino acid version of Ala, Lys, Orn, Glu, and Asp

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Wherein X at position 10 is defined as a number of the residue(s)
       selected from Gly and a D- or L- amino acid version of Ala, Lys, 
       Orn, Glu, and Asp, which is a number from 0 to 10

<400>  24

Xaa Tyr Phe Xaa Asn Cys Pro Lys Xaa Xaa Gly 
1               5                   10      


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<400>  25

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly 
1               5                   


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Wherein X at position 18 is defined as acetyl (Ac)

<400>  26

Xaa Tyr Phe Xaa Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Xaa Gly 
            


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as Lauric acid

<400>  27

Xaa Tyr Phe Xaa Asn Cys Pro Lys Xaa Gly 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as acetyl (Ac)

<400>  28

Xaa Tyr Phe Xaa Asn Cys Pro Lys Xaa Gly 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein X at position 9 is defined as diaminopimelic acid (Dap)

<400>  29

Xaa Tyr Phe Xaa Asn Cys Pro Lys Xaa Gly 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X at position 8 is defined as ornithine (Orn)

<400>  30

Xaa Tyr Phe Xaa Asn Cys Pro Xaa Gly 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 is defined as homoglutamine (Hgn)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X at position 8 is defined as diaminobutyric acid (Dab)

<400>  31

Xaa Tyr Phe Xaa Asn Cys Pro Xaa Gly 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<400>  32

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly 
1               5                   


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 is defined as mercaptopropionic acid 
       (Mpa)

<400>  33

Xaa Tyr Phe Gln Asn Cys Pro Lys Gly Gly Gly Gly Gly Gly 
1               5                   10                  


