                         SEQUENCE LISTING

<110>  Givaudan SA
 
<120>  METHOD FOR THE PRODUCTION OF MUSK FRAGRANCE INGREDIENT

<130>  IEC210226PCT

<150>  GB2011259.5
<151>  2020-07-21

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  280
<212>  PRT
<213>  Mycobacterium avium

<400>  1

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Thr Ala Ser Phe Ala Gly Leu Val Pro Asn Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Val Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  2
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  2

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Thr Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Val Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  3
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Thr Ala Ser Phe Ala Gly Leu Val Pro Asn Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  4
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Asn Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Val Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  5
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Glu Thr Lys Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  6
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  6

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  7
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  8
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Ala Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Val 
            180                 185                 190         


Val Glu Thr Lys Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Ser Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  9
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Gly Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Glu Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Glu Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  10
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Arg Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Phe Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Gly Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Glu Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  11
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  11

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Val Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Met Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val His Gly Gly Pro Leu Ala Gln Thr Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Met Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Thr Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Glu Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Ala Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  12
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Val Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Leu Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val His Gly Gly Pro Leu Ala Gln Thr Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Thr Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Glu Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Gly Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  13
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Val Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Met Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Gly Gly Pro Leu Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Glu Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Tyr Gly Met Ser Gly Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  14
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  14

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Val Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Met Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Gly Gly Pro Ile Ala Thr Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Gln Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Gly Gly Pro Ser Gly Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  15
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Val Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Met Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Gly Gly Pro Met Ala Gln Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Lys Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Gly Gly Arg Ser Gly Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


<210>  16
<211>  280
<212>  PRT
<213>  Escherichia coli

<400>  16

Met Asp Gly Phe Leu Ser Gly Phe Asp Gly Val Ala Ala Val Val Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Ile Gly Leu Ala Thr Ala Thr Glu Met Ala Arg 
            20                  25                  30          


Arg Gly Ala Arg Leu Val Leu Ser Asp Val Asp Gln Pro Ala Leu Glu 
        35                  40                  45              


Gln Ala Val Asn Gly Leu Arg Gly Gln Gly Phe Asp Ala His Gly Val 
    50                  55                  60                  


Val Cys Asp Val Arg His Leu Asp Glu Met Val Arg Leu Ala Asp Glu 
65                  70                  75                  80  


Ala Phe Arg Leu Leu Gly Gly Val Asp Val Val Phe Ser Asn Ala Gly 
                85                  90                  95      


Ile Val Val Gly Gly Pro Met Ala Thr Met Asn His Asp Asp Trp Arg 
            100                 105                 110         


Trp Val Ile Asp Ile Asp Leu Trp Gly Ser Ile His Ala Val Glu Ala 
        115                 120                 125             


Phe Leu Pro Arg Leu Leu Glu Gln Gly Thr Gly Gly His Ile Ala Phe 
    130                 135                 140                 


Asn Ala Ser Phe Ala Gly Leu Val Pro Val Ala Gly Leu Gly Thr Tyr 
145                 150                 155                 160 


Gly Val Ala Lys Tyr Gly Val Val Gly Leu Ala Glu Thr Leu Ala Arg 
                165                 170                 175     


Glu Val Lys Pro Asn Gly Ile Gly Val Ser Val Leu Cys Pro Met Tyr 
            180                 185                 190         


Val Lys Thr Asn Leu Leu Ser Asn Ser Glu Arg Ile Arg Gly Ala Asp 
        195                 200                 205             


Gly Gly Arg Ser Gly Thr Pro Glu Gly Ala Phe Gly Pro Leu Pro Thr 
    210                 215                 220                 


Gln Asp Tyr Ser Val Ser Ala Asp Asp Val Ala Arg Leu Thr Ala Asp 
225                 230                 235                 240 


Ala Ile Leu Ala Asn Arg Leu Tyr Ile Leu Pro His Ala Ala Ala Arg 
                245                 250                 255     


Glu Arg Ile Arg Arg Arg Phe Glu Arg Ile Asp Arg Thr Phe Asp Glu 
            260                 265                 270         


Gln Ala Ala Glu Gly Trp Thr His 
        275                 280 


