                         SEQUENCE LISTING

<110>  Philogen S.p.A.
 
<120>  TREATMENT OF PULMONARY HYPERTENSION

<130>  008020950

<140>  PCT/EP2021/070357
<141>  2021-07-21

<150>  EP 20187278.5
<151>  2020-07-22

<150>  EP 21150760.3
<151>  2021-01-08

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 CDR1 VH

<400>  1

Leu Phe Thr 
1           


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 CDR2 VH

<400>  2

Ser Gly Ser Gly Gly Ser 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 CDR3 VH

<400>  3

Ser Thr His Leu Tyr Leu 
1               5       


<210>  4
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 CDR1 VL

<400>  4

Met Pro Phe 
1           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 CDR2 VL

<400>  5

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 CDR3 VL

<400>  6

Met Arg Gly Arg Pro Pro 
1               5       


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 VH domain

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8 VL domain

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  9
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8(scFv)

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
    130                 135                 140                 


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met 
    210                 215                 220                 


Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  10
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8(Db)

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr 
        115                 120                 125             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
                165                 170                 175     


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Val Glu Ile Lys 
225                 230     


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSF VH domain

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  12
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSF VL domain

<400>  12

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Pro Leu Asn Arg Leu Ala 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  13
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSF(scFv)

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Pro Leu 
    210                 215                 220                 


Asn Arg Leu Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly 
    


<210>  14
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSF(Db)

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Glu Leu Thr Gln 
        115                 120                 125             


Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
    130                 135                 140                 


Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys 
145                 150                 155                 160 


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro 
                165                 170                 175     


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 
            180                 185                 190         


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
        195                 200                 205             


Cys Asn Ser Ser Pro Leu Asn Arg Leu Ala Val Val Phe Gly Gly Gly 
    210                 215                 220                 


Thr Lys Leu Thr Val Leu Gly 
225                 230     


<210>  15
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine IL9

<400>  15

Gln Arg Cys Ser Thr Thr Trp Gly Ile Arg Asp Thr Asn Tyr Leu Ile 
1               5                   10                  15      


Glu Asn Leu Lys Asp Asp Pro Pro Ser Lys Cys Ser Cys Ser Gly Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Ser Val Pro Thr Asp Asp Cys Thr Thr 
        35                  40                  45              


Pro Cys Tyr Arg Glu Gly Leu Leu Gln Leu Thr Asn Ala Thr Gln Lys 
    50                  55                  60                  


Ser Arg Leu Leu Pro Val Phe His Arg Val Lys Arg Ile Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Ile Thr Cys Pro Ser Phe Ser Cys Glu Lys Pro Cys Asn 
                85                  90                  95      


Gln Thr Met Ala Gly Asn Thr Leu Ser Phe Leu Lys Ser Leu Leu Gly 
            100                 105                 110         


Thr Phe Gln Lys Thr Glu Met Gln Arg Gln Lys Ser Arg Pro 
        115                 120                 125     


<210>  16
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL9

<400>  16

Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
1               5                   10                  15      


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
        35                  40                  45              


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
    50                  55                  60                  


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
                85                  90                  95      


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
            100                 105                 110         


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
        115                 120                 125     


<210>  17
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8(scFv)-mIL9-F8(scFv) ("CrAb" format)

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
    130                 135                 140                 


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met 
    210                 215                 220                 


Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Gln Arg Cys Ser Thr Thr 
                245                 250                 255     


Trp Gly Ile Arg Asp Thr Asn Tyr Leu Ile Glu Asn Leu Lys Asp Asp 
            260                 265                 270         


Pro Pro Ser Lys Cys Ser Cys Ser Gly Asn Val Thr Ser Cys Leu Cys 
        275                 280                 285             


Leu Ser Val Pro Thr Asp Asp Cys Thr Thr Pro Cys Tyr Arg Glu Gly 
    290                 295                 300                 


Leu Leu Gln Leu Thr Asn Ala Thr Gln Lys Ser Arg Leu Leu Pro Val 
305                 310                 315                 320 


Phe His Arg Val Lys Arg Ile Val Glu Val Leu Lys Asn Ile Thr Cys 
                325                 330                 335     


Pro Ser Phe Ser Cys Glu Lys Pro Cys Asn Gln Thr Met Ala Gly Asn 
            340                 345                 350         


Thr Leu Ser Phe Leu Lys Ser Leu Leu Gly Thr Phe Gln Lys Thr Glu 
        355                 360                 365             


Met Gln Arg Gln Lys Ser Arg Pro Ser Gly Gly Ser Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
385                 390                 395                 400 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                405                 410                 415     


Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            420                 425                 430         


Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
    450                 455                 460                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
        515                 520                 525             


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
    530                 535                 540                 


Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
545                 550                 555                 560 


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
                565                 570                 575     


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            580                 585                 590         


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
        595                 600                 605             


Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
    610                 615                 620                 


Ile Lys 
625     


<210>  18
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F8(scFv)-hIL9-F8(scFv) ("CrAb" format)

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
    130                 135                 140                 


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
145                 150                 155                 160 


Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met 
    210                 215                 220                 


Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Gln Gly Cys Pro Thr Leu 
                245                 250                 255     


Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp 
            260                 265                 270         


Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys 
        275                 280                 285             


Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg 
    290                 295                 300                 


Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile 
305                 310                 315                 320 


Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys 
                325                 330                 335     


Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn 
            340                 345                 350         


Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys 
        355                 360                 365             


Met Arg Gly Met Arg Gly Lys Ile Ser Gly Gly Ser Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
385                 390                 395                 400 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                405                 410                 415     


Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            420                 425                 430         


Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
    450                 455                 460                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
        515                 520                 525             


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
    530                 535                 540                 


Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
545                 550                 555                 560 


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
                565                 570                 575     


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            580                 585                 590         


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
        595                 600                 605             


Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
    610                 615                 620                 


Ile Lys 
625     


<210>  19
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KSF(scFv)-mIL9-KSF(scFv) ("CrAb" format)

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Pro Leu 
    210                 215                 220                 


Asn Arg Leu Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


Gly Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly Gln Arg Cys Ser Thr 
                245                 250                 255     


Thr Trp Gly Ile Arg Asp Thr Asn Tyr Leu Ile Glu Asn Leu Lys Asp 
            260                 265                 270         


Asp Pro Pro Ser Lys Cys Ser Cys Ser Gly Asn Val Thr Ser Cys Leu 
        275                 280                 285             


Cys Leu Ser Val Pro Thr Asp Asp Cys Thr Thr Pro Cys Tyr Arg Glu 
    290                 295                 300                 


Gly Leu Leu Gln Leu Thr Asn Ala Thr Gln Lys Ser Arg Leu Leu Pro 
305                 310                 315                 320 


Val Phe His Arg Val Lys Arg Ile Val Glu Val Leu Lys Asn Ile Thr 
                325                 330                 335     


Cys Pro Ser Phe Ser Cys Glu Lys Pro Cys Asn Gln Thr Met Ala Gly 
            340                 345                 350         


Asn Thr Leu Ser Phe Leu Lys Ser Leu Leu Gly Thr Phe Gln Lys Thr 
        355                 360                 365             


Glu Met Gln Arg Gln Lys Ser Arg Pro Ser Gly Gly Ser Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
385                 390                 395                 400 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                405                 410                 415     


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            420                 425                 430         


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    450                 455                 460                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly 
                485                 490                 495     


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala 
        515                 520                 525             


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
    530                 535                 540                 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
            580                 585                 590         


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
        595                 600                 605             


Ser Pro Leu Asn Arg Leu Ala Val Val Phe Gly Gly Gly Thr Lys Leu 
    610                 615                 620                 


Thr Val Leu Gly 
625             


<210>  20
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  of murine IL9 conjugated to the C-terminus of the F8 diabody 
       (F8(Db)-mIL9)

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr 
        115                 120                 125             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
                165                 170                 175     


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gln Arg Cys Ser Thr Thr Trp Gly Ile Arg 
                245                 250                 255     


Asp Thr Asn Tyr Leu Ile Glu Asn Leu Lys Asp Asp Pro Pro Ser Lys 
            260                 265                 270         


Cys Ser Cys Ser Gly Asn Val Thr Ser Cys Leu Cys Leu Ser Val Pro 
        275                 280                 285             


Thr Asp Asp Cys Thr Thr Pro Cys Tyr Arg Glu Gly Leu Leu Gln Leu 
    290                 295                 300                 


Thr Asn Ala Thr Gln Lys Ser Arg Leu Leu Pro Val Phe His Arg Val 
305                 310                 315                 320 


Lys Arg Ile Val Glu Val Leu Lys Asn Ile Thr Cys Pro Ser Phe Ser 
                325                 330                 335     


Cys Glu Lys Pro Cys Asn Gln Thr Met Ala Gly Asn Thr Leu Ser Phe 
            340                 345                 350         


Leu Lys Ser Leu Leu Gly Thr Phe Gln Lys Thr Glu Met Gln Arg Gln 
        355                 360                 365             


Lys Ser Arg Pro 
    370         


<210>  21
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine IL9 conjugated to the N-terminus of the F8 diabody 
       (mIL9-F8(Db))

<400>  21

Gln Arg Cys Ser Thr Thr Trp Gly Ile Arg Asp Thr Asn Tyr Leu Ile 
1               5                   10                  15      


Glu Asn Leu Lys Asp Asp Pro Pro Ser Lys Cys Ser Cys Ser Gly Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Ser Val Pro Thr Asp Asp Cys Thr Thr 
        35                  40                  45              


Pro Cys Tyr Arg Glu Gly Leu Leu Gln Leu Thr Asn Ala Thr Gln Lys 
    50                  55                  60                  


Ser Arg Leu Leu Pro Val Phe His Arg Val Lys Arg Ile Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Ile Thr Cys Pro Ser Phe Ser Cys Glu Lys Pro Cys Asn 
                85                  90                  95      


Gln Thr Met Ala Gly Asn Thr Leu Ser Phe Leu Lys Ser Leu Leu Gly 
            100                 105                 110         


Thr Phe Gln Lys Thr Glu Met Gln Arg Gln Lys Ser Arg Pro Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile 
            180                 185                 190         


Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser 
225                 230                 235                 240 


Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro 
            260                 265                 270         


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
        275                 280                 285             


Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys 
    290                 295                 300                 


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
305                 310                 315                 320 


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                325                 330                 335     


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            340                 345                 350         


Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        355                 360                 365             


Val Glu Ile Lys 
    370         


<210>  22
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL9 conjugated to the C-terminus of the F8 diabody 
       (F8(Db)-hIL9)

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr 
        115                 120                 125             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    130                 135                 140                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
                165                 170                 175     


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln 
    210                 215                 220                 


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu 
                245                 250                 255     


Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys 
            260                 265                 270         


Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro 
        275                 280                 285             


Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met 
    290                 295                 300                 


Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val 
305                 310                 315                 320 


Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser 
                325                 330                 335     


Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe 
            340                 345                 350         


Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met 
        355                 360                 365             


Arg Gly Lys Ile 
    370         


<210>  23
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL9 conjugated to the N-terminus of the F8 diabody 
       (hIL9-F8(Db))

<400>  23

Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile 
1               5                   10                  15      


Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn 
            20                  25                  30          


Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg 
        35                  40                  45              


Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln 
    50                  55                  60                  


Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val 
65                  70                  75                  80  


Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn 
                85                  90                  95      


Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu 
            100                 105                 110         


Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile 
            180                 185                 190         


Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser 
225                 230                 235                 240 


Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro 
            260                 265                 270         


Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
        275                 280                 285             


Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys 
    290                 295                 300                 


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
305                 310                 315                 320 


Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                325                 330                 335     


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            340                 345                 350         


Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        355                 360                 365             


Val Glu Ile Lys 
    370         


<210>  24
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine IL9 conjugated to the C-terminus of the KSF diabody 
       (KSF(Db)-mIL9)

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Glu Leu Thr Gln 
        115                 120                 125             


Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
    130                 135                 140                 


Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys 
145                 150                 155                 160 


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro 
                165                 170                 175     


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 
            180                 185                 190         


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
        195                 200                 205             


Cys Asn Ser Ser Pro Leu Asn Arg Leu Ala Val Val Phe Gly Gly Gly 
    210                 215                 220                 


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gln Arg Cys Ser Thr Thr Trp Gly Ile Arg 
                245                 250                 255     


Asp Thr Asn Tyr Leu Ile Glu Asn Leu Lys Asp Asp Pro Pro Ser Lys 
            260                 265                 270         


Cys Ser Cys Ser Gly Asn Val Thr Ser Cys Leu Cys Leu Ser Val Pro 
        275                 280                 285             


Thr Asp Asp Cys Thr Thr Pro Cys Tyr Arg Glu Gly Leu Leu Gln Leu 
    290                 295                 300                 


Thr Asn Ala Thr Gln Lys Ser Arg Leu Leu Pro Val Phe His Arg Val 
305                 310                 315                 320 


Lys Arg Ile Val Glu Val Leu Lys Asn Ile Thr Cys Pro Ser Phe Ser 
                325                 330                 335     


Cys Glu Lys Pro Cys Asn Gln Thr Met Ala Gly Asn Thr Leu Ser Phe 
            340                 345                 350         


Leu Lys Ser Leu Leu Gly Thr Phe Gln Lys Thr Glu Met Gln Arg Gln 
        355                 360                 365             


Lys Ser Arg Pro 
    370         


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker between the VH domain and the VL domain in the F8(scFv) or
       in the KSF(scFv)

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the linker between the VH domain and the VL domain in the F8(Db) 
       or in the KSF(Db)

<400>  26

Gly Gly Ser Gly Gly 
1               5   


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker between murine IL9 or human IL9 and F8(Db) or KSF(Db)

<400>  27

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker between murine IL9 or human IL9 and the F8(scFv) or the 
       KSF(scFv) in CrAb format

<400>  28

Ser Gly Gly Ser Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  29
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader sequence-ScFvF8-linker - Forward Primer

<400>  29
tcctcctgtt cctcgtcgct gtggctacag gtgtgcactc ggaggtgcag ctgttggagt       60

ctggg                                                                   65


<210>  30
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader sequence-ScFvF8-linker - Backward Primer

<400>  30
acctccaccg ccagaaccac ttccgcctga tttgatttcc accttggtcc cttg             54


<210>  31
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker - hIL9-Linker - Forward Primer

<400>  31
tcaggcggaa gtggttctgg cggtggaggt caggggtgtc caaccttggc gggg             54


<210>  32
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker - hIL9-Linker - Backward Primer and 
       HindIII-Leader_sequence-ScFvF8-Linker-IL9-Linker - Backward 
       Primer

<400>  32
cccctgaacc actgcctcca gatatcttgc ct                                     32


<210>  33
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-mIL9-Linker - Forward Primer

<400>  33
tcaggcggaa gtggttctgg cggtggaggt cagagatgca gcaccacatg ggg              53


<210>  34
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-mIL9-Linker - Backward Primer and HindIII-Leader 
       sequence-ScFvF8-Linker-mIL9-Linker - back ward

<400>  34
ccccctgaac cactgcctcc agatggtcgg ctt                                    33


<210>  35
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-ScFv8-STOP-NotI - Forward Primer

<400>  35
gcagtggttc agggggcggt ggagaggtgc agctgt                                 36


<210>  36
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-ScFv8-STOP-NotI - Backward Primer and 
       Linker-IL9-Linker-ScFv8-STOP-NotI - Backward Primer

<400>  36
ttttcctttt gcggccgctt atttgatttc caccttggtc cc                          42


<210>  37
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HindIII-Leader_sequence-ScFvF8-Linker-IL9-Linker - Forward Primer

<400>  37
cccaagcttg tcgaccatgg gctggagcct gatcctcctg ttcctcgtcg ctgtggc          57


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-hIL9-Linker-ScFv8-STOP-NotI - Forward Primer

<400>  38
caggggtgtc caaccttggc gggga                                             25


<210>  39
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker-mIL9-Linker-ScFv8-STOP-NotI - Forward Primer

<400>  39
cagagatgca gcaccacatg ggga                                              24


<210>  40
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HindIII-Leader_sequence -DbF8 - Forward Primer; 
       HindIII-Leader_sequence -IL9 - Forward primer; 
       HindIII-Leader_sequence -KSF(VH) - Forward Primer and 
       HindIII-Leader_sequence -DbKSF - forward primer

<400>  40
attaaagctt ccaccatggg ctggagcctg atcctcctgt tcctcgtcgc tgtggc           56


<210>  41
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HindIII-Leader_sequence -DbF8 - backward primer

<400>  41
gccagagcca cctccgcctg aaccgcctcc acctttgatt tccaccttgg tccc             54


<210>  42
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIL9-Stop-NotI - Forward primer

<400>  42
caggcggagg tggctctggc ggtggcggat cacaggggtg tccaaccttg                  50


<210>  43
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIL9-Stop-NotI - Backward primer

<400>  43
taatgcggcc gcttatcata tcttgcctct catccctct                              39


<210>  44
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIL9-Stop-NotI - Forward primer

<400>  44
caggcggagg tggctctggc ggtggcggat cacagagatg cagcaccaca                  50


<210>  45
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIL9-Stop-NotI - Backward Primer

<400>  45
taatgcggcc gcttatcatg gtcggctttt ctgcctttgc at                          42


<210>  46
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader_sequence-hIL9 - Forward Primer

<400>  46
tcctcctgtt cctcgtcgct gtggctacag gtgtgcactc gcaggggtgt ccaaccttg        59


<210>  47
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader_sequence-hIL9 - Backward Primer

<400>  47
gccagagcca cctccgcctg aaccgcctcc acctatcttg cctctcatcc ctct             54


<210>  48
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader_sequence-mIL9 - Forward Primer

<400>  48
tcctcctgtt cctcgtcgct gtggctacag gtgtgcactc gcagagatgc agcaccaca        59


<210>  49
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader_sequence-mIL9 - Backward Primer and 
       HindIII-Leader_sequence -mIL9 - Backward Primer

<400>  49
gccagagcca cctccgcctg aaccgcctcc acctggtcgg cttttctgcc tttgcat          57


<210>  50
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DbF8-Stop-NotI - Forward Primer

<400>  50
caggcggagg tggctctggc ggtggcggat cagaggtgca gctgttggag tct              53


<210>  51
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DbF8-Stop-NotI - Backward Primer

<400>  51
taatgcggcc gcttatcatt tgatttccac cttggtccc                              39


<210>  52
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HindIII-Leader_sequence -KSF(VH) - Backward Primer

<400>  52
accgccagag ccacctccgc ctgaaccgcc tccaccactc gagacggtga ccaggg           56


<210>  53
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KSF(VL)-linker - Forward Primer

<400>  53
aggcggttca ggcggaggtg gctctggcgg tggcggatcg tctgagctga ctcagga          57


<210>  54
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KSF(VL)-linker - Backward Primer

<400>  54
ctctgacctc caccgccaga accacttccg cctgagccta ggacggtcag cttggt           56


<210>  55
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker-mIL9-KSF(ScFv)-NotI - Forward Primer

<400>  55
atggggaatt cgagacacca attaccttat tgaa                                   34


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker-mIL9-KSF(ScFv)-NotI - Backward Primer

<400>  56
taatgcggcc gcttatcatc ccagcactgt cagctt                                 36


<210>  57
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HindIII-Leader_sequence -DbKSF - Backward Primer

<400>  57
aatcggctgg ctgtggtatt cggcggaggg accaagctga ccgtcctagg cggtggaggc       60

ggttcaggcg gaggtggctc tggc                                              84


<210>  58
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment-A sequence - Forward Primer

<400>  58
tttgactact ggggccaggg aaccctggtc accgtctc                               38


<210>  59
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment-A sequence - Backward Primer

<400>  59
ccaccgccag agccacctcc gcctgaaccg cctccaccac ccagagacag ggagaggctc       60

ttc                                                                     63


<210>  60
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the F8 heavy chain

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210>  61
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the F8 light chain in the F8 
       (IgG4-HC)-mIL9 and F8 (IgG4-HC)-hIL9 conjugates

<400>  61

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  62
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of F8 heavy chain-mIL9 in the F8 
       (IgG4-HC)-mIL9 conjugate

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Arg Cys Ser Thr 
    450                 455                 460                 


Thr Trp Gly Ile Arg Asp Thr Asn Tyr Leu Ile Glu Asn Leu Lys Asp 
465                 470                 475                 480 


Asp Pro Pro Ser Lys Cys Ser Cys Ser Gly Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Ser Val Pro Thr Asp Asp Cys Thr Thr Pro Cys Tyr Arg Glu 
            500                 505                 510         


Gly Leu Leu Gln Leu Thr Asn Ala Thr Gln Lys Ser Arg Leu Leu Pro 
        515                 520                 525             


Val Phe His Arg Val Lys Arg Ile Val Glu Val Leu Lys Asn Ile Thr 
    530                 535                 540                 


Cys Pro Ser Phe Ser Cys Glu Lys Pro Cys Asn Gln Thr Met Ala Gly 
545                 550                 555                 560 


Asn Thr Leu Ser Phe Leu Lys Ser Leu Leu Gly Thr Phe Gln Lys Thr 
                565                 570                 575     


Glu Met Gln Arg Gln Lys Ser Arg Pro 
            580                 585 


<210>  63
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of F8 heavy chain-huIL9 in the F8 
       (IgG4-HC)-hIL9 conjugate

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile 
            580                 585 

<210>  64
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of KSF light chain in KSF (IgG4-HC)-mIL9 and 
       KSF (IgG4-HC)-hIL9 conjugates

<400>  64

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Pro Leu Asn Arg Leu Ala 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  65
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of KSF heavy chain-mIL9 in the KSF 
       (IgG4-HC)-mIL9 conjugate

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Arg Cys Ser Thr 
    450                 455                 460                 


Thr Trp Gly Ile Arg Asp Thr Asn Tyr Leu Ile Glu Asn Leu Lys Asp 
465                 470                 475                 480 


Asp Pro Pro Ser Lys Cys Ser Cys Ser Gly Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Ser Val Pro Thr Asp Asp Cys Thr Thr Pro Cys Tyr Arg Glu 
            500                 505                 510         


Gly Leu Leu Gln Leu Thr Asn Ala Thr Gln Lys Ser Arg Leu Leu Pro 
        515                 520                 525             


Val Phe His Arg Val Lys Arg Ile Val Glu Val Leu Lys Asn Ile Thr 
    530                 535                 540                 


Cys Pro Ser Phe Ser Cys Glu Lys Pro Cys Asn Gln Thr Met Ala Gly 
545                 550                 555                 560 


Asn Thr Leu Ser Phe Leu Lys Ser Leu Leu Gly Thr Phe Gln Lys Thr 
                565                 570                 575     


Glu Met Gln Arg Gln Lys Ser Arg Pro 
            580                 585 


<210>  66
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of KSF heavy chain-hIL9 in the KSF 
       (IgG4-HC)-hIL9 conjugate

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Pro Lys Val Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Cys Pro Thr 
    450                 455                 460                 


Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met Gln Glu 
465                 470                 475                 480 


Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser Cys Leu 
                485                 490                 495     


Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe Ser Glu 
            500                 505                 510         


Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr Pro Leu 
        515                 520                 525             


Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn Asn Lys 
    530                 535                 540                 


Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr Ala Gly 
545                 550                 555                 560 


Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln Lys Glu 
                565                 570                 575     


Lys Met Arg Gly Met Arg Gly Lys Ile 
            580                 585 




