                         SEQUENCE LISTING

<110>  STRAND THERAPEUTICS INC.
 
<120>  LIPIDNANOPARTICLE COMPRISING MODIFIED NUCLEOTIDES

<130>  4597.004PC01

<150>  US 63/056,382
<151>  2020-07-24

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-type human IL-12

<400>  1

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Met Cys His Gln Gln 
    210                 215                 220                 


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
225                 230                 235                 240 


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
                245                 250                 255     


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
            260                 265                 270         


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
        275                 280                 285             


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
    290                 295                 300                 


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
305                 310                 315                 320 


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
                325                 330                 335     


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
            340                 345                 350         


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
        355                 360                 365             


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
    370                 375                 380                 


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
385                 390                 395                 400 


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
                405                 410                 415     


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
            420                 425                 430         


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        435                 440                 445             


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
    450                 455                 460                 


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
465                 470                 475                 480 


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
                485                 490                 495     


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
            500                 505                 510         


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
        515                 520                 525             


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
    530                 535                 540                 


Pro Cys Ser 
545         


<210>  2
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 alpha

<400>  2

Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      


Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210>  3
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 beta

<400>  3

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  4
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 amino acid

<400>  4

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser 
    530         


<210>  5
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12 amino acid

<400>  5

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Ser Gly Gly Gly Gly Ser 
                325                 330                 335     


Pro Gly Gly Gly Ser Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            340                 345                 350         


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        355                 360                 365             


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    370                 375                 380                 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
385                 390                 395                 400 


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                405                 410                 415     


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            420                 425                 430         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        435                 440                 445             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    450                 455                 460                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
465                 470                 475                 480 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                485                 490                 495     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            500                 505                 510         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        515                 520                 525             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 


<210>  6
<211>  1596
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA coding IL-12

<400>  6
augugccacc agcagcuggu gaucagcugg uucagccugg uguuccuggc cagcccccug       60

guggccaucu gggagcugaa gaaggacgug uacguggugg aguuggauug guaccccgac      120

gcccccggcg agaugguggu gcugaccugc gacacccccg aggaggacgg caucaccugg      180

acccuggacc agagcagcga ggugcugggc agcggcaaga cccugaccau ccaggugaag      240

gaguucggcg acgccggcca guacaccugc cacaagggcg gcgaggugcu gagccacagc      300

cugcugcugc ugcacaagaa ggaggacggc aucuggagca ccgacauccu gaaggaccag      360

aaggagccca agaacaagac cuuccugaga ugcgaggcca agaacuacag cggcagauuc      420

accugcuggu ggcugaccac caucagcacc gaccugaccu ucagcgugaa gagcagcaga      480

ggcagcagcg acccccaggg cgugaccugc ggcgccgcca cccugagcgc cgagagagug      540

agaggcgaca acaaggagua cgaguacagc guggagugcc aggaagauag cgccugcccc      600

gccgccgagg agagccugcc caucgaggug augguggacg ccgugcacaa gcugaaguac      660

gagaacuaca ccagcagcuu cuucaucaga gauaucauca agcccgaccc ccccaagaac      720

cugcagcuga agccccugaa gaacagccgg cagguggagg ugagcuggga guaccccgac      780

accuggagca ccccccacag cuacuucagc cugaccuucu gcgugcaggu gcagggcaag      840

agcaagagag agaagaaaga uagaguguuc accgacaaga ccagcgccac cgugaucugc      900

agaaagaacg ccagcaucag cgugagagcc caagauagau acuacagcag cagcuggagc      960

gagugggcca gcgugcccug cagcggcggc ggcggcggcg gcagcagaaa ccugcccgug     1020

gccacccccg accccggcau guuccccugc cugcaccaca gccagaaccu gcugagagcc     1080

gugagcaaca ugcugcagaa ggcccggcag acccuggagu ucuaccccug caccagcgag     1140

gagaucgacc acgaagauau caccaaagau aagaccagca ccguggaggc cugccugccc     1200

cuggagcuga ccaagaacga gagcugccug aacagcagag agaccagcuu caucaccaac     1260

ggcagcugcc uggccagcag aaagaccagc uucaugaugg cccugugccu gagcagcauc     1320

uacgaggacc ugaagaugua ccagguggag uucaagacca ugaacgccaa gcugcugaug     1380

gaccccaagc ggcagaucuu ccuggaccag aacaugcugg ccgugaucga cgagcugaug     1440

caggcccuga acuucaacag cgagaccgug ccccagaaga gcagccugga ggagcccgac     1500

uucuacaaga ccaagaucaa gcugugcauc cugcugcacg ccuucagaau cagagccgug     1560

accaucgaca gagugaugag cuaccugaac gccagc                               1596


<210>  7
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA coding IL-12

<400>  7
augugucacc agcaguuggu caucucuugg uuuucccugg uuuuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaaa cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaaaaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca aaaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa aagcagcaga      480

gggucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gaaaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag aaaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaaaaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguggcucu agcggagggg gaggcucucc uggcggggga     1020

ucuagcagaa accuccccgu ggccacucca gacccaggaa uguucccaug ccuucaccac     1080

ucccaaaacc ugcugagggc cgucagcaac augcuccaga aggccagaca aacucuagaa     1140

uuuuacccuu gcacuucuga ggaaauugau caugaagaua ucacaaaaga uaaaaccagc     1200

acaguggagg ccuguuuacc auuggaauua accaagaaug agaguugccu aaauuccaga     1260

gagaccucuu ucauaacuaa ugggaguugc cuggccucca gaaagaccuc uuuuaugaug     1320

gcccugugcc uuaguaguau uuaugaagac uugaagaugu accaggugga guucaagacc     1380

augaaugcaa agcuucugau ggauccuaag aggcagaucu uucuagauca aaacaugcug     1440

gcaguuauug augagcugau gcaggcccug aauuucaaca gugagacugu gccacaaaaa     1500

uccucccuug aagaaccgga uuuuuauaaa acuaaaauca agcucugcau acuucuucau     1560

gcuuucagaa uucgggcagu gacuauugau agagugauga gcuaucugaa ugcuuccuga     1620

uga                                                                   1623


<210>  8
<211>  1890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA with regulator elements

<400>  8
ggggaaataa gagagaaaag aagagtaaga agaaatataa gagccaccat gtgccaccag       60

cagctggtga tcagctggtt cagcctggtg ttcctggcca gccccctggt ggccatctgg      120

gagctgaaga aggacgtgta cgtggtggag ttggattggt accccgacgc ccccggcgag      180

atggtggtgc tgacctgcga cacccccgag gaggacggca tcacctggac cctggaccag      240

agcagcgagg tgctgggcag cggcaagacc ctgaccatcc aggtgaagga gttcggcgac      300

gccggccagt acacctgcca caagggcggc gaggtgctga gccacagcct gctgctgctg      360

cacaagaagg aggacggcat ctggagcacc gacatcctga aggaccagaa ggagcccaag      420

aacaagacct tcctgagatg cgaggccaag aactacagcg gcagattcac ctgctggtgg      480

ctgaccacca tcagcaccga cctgaccttc agcgtgaaga gcagcagagg cagcagcgac      540

ccccagggcg tgacctgcgg cgccgccacc ctgagcgccg agagagtgag aggcgacaac      600

aaggagtacg agtacagcgt ggagtgccag gaagatagcg cctgccccgc cgccgaggag      660

agcctgccca tcgaggtgat ggtggacgcc gtgcacaagc tgaagtacga gaactacacc      720

agcagcttct tcatcagaga tatcatcaag cccgaccccc ccaagaacct gcagctgaag      780

cccctgaaga acagccggca ggtggaggtg agctgggagt accccgacac ctggagcacc      840

ccccacagct acttcagcct gaccttctgc gtgcaggtgc agggcaagag caagagagag      900

aagaaagata gagtgttcac cgacaagacc agcgccaccg tgatctgcag aaagaacgcc      960

agcatcagcg tgagagccca agatagatac tacagcagca gctggagcga gtgggccagc     1020

gtgccctgca gcggcggcgg cggcggcggc agcagaaacc tgcccgtggc cacccccgac     1080

cccggcatgt tcccctgcct gcaccacagc cagaacctgc tgagagccgt gagcaacatg     1140

ctgcagaagg cccggcagac cctggagttc tacccctgca ccagcgagga gatcgaccac     1200

gaagatatca ccaaagataa gaccagcacc gtggaggcct gcctgcccct ggagctgacc     1260

aagaacgaga gctgcctgaa cagcagagag accagcttca tcaccaacgg cagctgcctg     1320

gccagcagaa agaccagctt catgatggcc ctgtgcctga gcagcatcta cgaggacctg     1380

aagatgtacc aggtggagtt caagaccatg aacgccaagc tgctgatgga ccccaagcgg     1440

cagatcttcc tggaccagaa catgctggcc gtgatcgacg agctgatgca ggccctgaac     1500

ttcaacagcg agaccgtgcc ccagaagagc agcctggagg agcccgactt ctacaagacc     1560

aagatcaagc tgtgcatcct gctgcacgcc ttcagaatca gagccgtgac catcgacaga     1620

gtgatgagct acctgaacgc cagctgataa taggctggag cctcggtggc catgcttctt     1680

gccccttggg cctcccccca gcccctcctc cccttcctgc acccgtaccc cccaaacacc     1740

attgtcacac tccagtggtc tttgaataaa gtctgagtgg gcggcaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaatctag                                      1890


<210>  9
<211>  1623
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA with regulator elements

<400>  9
augugucacc agcagcuggu gaucucaugg uucucccugg uauuucuggc aucuccucuu       60

gucgcaaucu gggaacugaa gaaagacgug uaugucguug agcucgacug guauccggau      120

gcgccuggcg agaugguggu gcugaccugu gacaccccag aggaggaugg gaucacuugg      180

acccuugauc aauccuccga agugcucggg ucuggcaaga cucugaccau acaagugaaa      240

gaguuuggcg augccgggca guacacuugc cauaagggcg gagaaguucu gucccacuca      300

cugcugcugc ugcacaagaa agaggacgga auuuggagua ccgauauccu gaaagaucag      360

aaagagccca agaacaaaac cuucuugcgg ugcgaagcca agaacuacuc agggagauuu      420

acuuguuggu ggcugacgac gaucagcacc gaucugacuu ucuccgugaa aucaaguagg      480

ggaucaucug acccucaagg agucacaugu ggagcggcua cucugagcgc ugaacgcgua      540

agaggggaca auaaggagua cgaguauagc guugagugcc aagaggauag cgcaugcccc      600

gccgccgaag aaucauugcc cauugaagug augguggaug cuguacacaa gcugaaguau      660

gagaacuaca caagcuccuu cuucauccgu gacaucauca aaccagaucc uccuaagaac      720

cuccagcuua aaccucugaa gaacucuaga cagguggaag ugucuuggga guaucccgac      780

accuggucua caccacauuc cuacuucagu cucacauucu gcguucaggu acagggcaag      840

uccaaaaggg agaagaagga ucgggucuuu acagauaaaa caagugccac cguuauaugc      900

cggaagaaug ccucuauuuc ugugcgugcg caggacagau acuauagcag cucuuggagu      960

gaaugggcca gugucccaug uucaggguca uccgguggug gcggcagccc cggaggcggu     1020

agcuccagaa aucucccugu ggcuacaccu gauccaggca uguuucccug uuugcaccau     1080

agccaaaacc uccugagagc agucagcaac augcuccaga aagcuagaca aacacuggaa     1140

uucuacccau gcaccuccga ggaaauagau cacgaggaua ucacuaagga caaaacaagc     1200

acugucgaag caugccuucc cuuggaacug acaaagaacg agaguugccu uaauucaaga     1260

gaaacaucuu ucauuacaaa cgguagcugc uuggcaagca gaaaaacauc uuuuaugaug     1320

gcccuuuguc ugagcaguau uuaugaggau cucaaaaugu accaggugga guuuaagacc     1380

augaaugcca agcugcugau ggacccaaag agacagauuu uccucgauca gaauaugcug     1440

gcugugauug augaacugau gcaggccuug aauuucaaca gcgaaaccgu uccccagaaa     1500

agcagucuug aagaaccuga cuuuuauaag accaagauca aacuguguau ucuccugcau     1560

gccuuuagaa ucagagcagu cacuauagau agagugaugu ccuaccugaa ugcuuccuga     1620

uga                                                                   1623


