﻿                         序列表

<110>  北京市神经外科研究所

<120>  抗TIM3的单链抗体及其在制备治疗肿瘤的药物中的用途

<130>  17157BJNI-LGZ

<160>  6

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  232
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser His 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          
Gly Tyr Tyr Trp Ser Trp Thr Arg Gln His Pro Gly Met Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ser Ile Tyr Tyr Thr Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Ser Leu Asp Ser Trp Gly Ser Asn Arg Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Ile Val 
        115                 120                 125             
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    130                 135                 140                 
Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp 
145                 150                 155                 160 
Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala 
                165                 170                 175     
Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         
Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
        195                 200                 205             
Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu Thr Phe Gly 
    210                 215                 220                 
Gly Gly Thr Lys Val Glu Ile Lys 
225                 230         

<210>  2
<211>  696
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  2
caggtgcagc tacagcagtc gggcccagga ctggtgaagc cttcacacac cctgtccctc        60
acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ttggacccgt       120
cagcacccag ggatgggcct ggagtggatt ggatacatct cttacagtgg gagtatctat       180
tacactccgt ccctcaagag tcgacttacc atatcagtgg acacgtctaa gaaccagttc       240
tccctgaagc tgagctctgt gactgccgcg gacacggccg tatattactg tgcgagtttg       300
gattcctggg gatctaaccg tgactactgg ggccagggaa ccctggtcac cgtctcgagt       360
ggaggtggtg gatccgaaat tgtgttgacg cagtctccag ccaccctgtc tttgtctcca       420
ggggaaagag ccaccctctc ctgcagggcc agtcagagtg ttagcagcta cttagcctgg       480
taccaacaga aacctggcca ggctcccagg ctcctcatct atgatgcatc caacagggcc       540
actggcatcc cagccaggtt cagtggcagt gggtctggga cagacttcac tctcaccatc       600
agcagcctag agcctgaaga ttttgcagtt tattactgtc agcagcgtag caactggccg       660
ctcactttcg gcggagggac caaggtggag attaag                                 696

<210>  3
<211>  998
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Ser Asp Tyr Arg Gly Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu Thr 
    130                 135                 140                 
Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 
Ser Cys Arg Ala Ser Gln Ser Val Ile Asn Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         
Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            260                 265                 270         
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        275                 280                 285             
Thr Phe Thr Asp Phe Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
    290                 295                 300                 
Gly Leu Glu Trp Met Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala 
305                 310                 315                 320 
Tyr Asn Leu Lys Phe Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                325                 330                 335     
Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 
            340                 345                 350         
Ala Val Tyr Tyr Cys Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly 
        355                 360                 365             
Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly 
    370                 375                 380                 
Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser 
385                 390                 395                 400 
Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
                405                 410                 415     
Arg Ser Ser Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser 
            420                 425                 430         
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly 
        435                 440                 445             
Ile Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 
Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
465                 470                 475                 480 
Val Gly Val Tyr Tyr Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe 
                485                 490                 495     
Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
            500                 505                 510         
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        515                 520                 525             
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    530                 535                 540                 
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
545                 550                 555                 560 
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                565                 570                 575     
Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            580                 585                 590         
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        595                 600                 605             
Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    610                 615                 620                 
Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
625                 630                 635                 640 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                645                 650                 655     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            660                 665                 670         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        675                 680                 685             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    690                 695                 700                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
705                 710                 715                 720 
Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys 
                725                 730                 735     
Gly Asp Val Glu Glu Asn Pro Gly Pro Met Thr Asn Lys Cys Leu Leu 
            740                 745                 750         
Gln Ile Ala Leu Leu Leu Cys Phe Ser Thr Thr Ala Leu Ser Gln Val 
        755                 760                 765             
Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser His Thr Leu 
    770                 775                 780                 
Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Gly Tyr 
785                 790                 795                 800 
Tyr Trp Ser Trp Thr Arg Gln His Pro Gly Met Gly Leu Glu Trp Ile 
                805                 810                 815     
Gly Tyr Ile Ser Tyr Ser Gly Ser Ile Tyr Tyr Thr Pro Ser Leu Lys 
            820                 825                 830         
Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        835                 840                 845             
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    850                 855                 860                 
Ser Leu Asp Ser Trp Gly Ser Asn Arg Asp Tyr Trp Gly Gln Gly Thr 
865                 870                 875                 880 
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
                885                 890                 895     
Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            900                 905                 910         
Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
        915                 920                 925             
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
    930                 935                 940                 
Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
945                 950                 955                 960 
Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
                965                 970                 975     
Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu Thr Phe Gly Gly Gly 
            980                 985                 990         
Thr Lys Val Glu Ile Lys 
        995             

<210>  4
<211>  2994
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc        60
tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct       120
ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaattctat       180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat       240
ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaggagaagt       300
gactacaggg gctactacgg tatggacgtc tggggccaag ggaccacggt caccgtctcc       360
tcaggcagta ctagcggtgg tggctccggg ggcggttccg gtgggggcgg cagcagcgaa       420
attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc       480
tcctgcaggg ccagtcagag tgttatcaac tacttagcct ggtaccaaca gaaacctggc       540
caggctccca ggctcctcat ctatgatgca tccaacaggg cctctggcat cccagccagg       600
ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa       660
gattttgcag tttattactg tcagcagcgt cgcaactggc cgctcacttt cggcggaggg       720
accaaggtgg agatcaaagg aggtggtgga tccggaggtg gtggctccgg aggtggtgga       780
tcccaggttc agctggtgca gtctggagct gaggtgaaga agcctggggc ctcagtgaag       840
gtctcctgca aggcttctgg ttacaccttt accgactttg aaatgcactg ggtgcgacag       900
gcccctggac aagggcttga gtggatggga gatattgatc ctggaactgg tgatactgcc       960
tacaatctga agttcaaggg cagagtcacc atgaccacag acacatccac gagcacagcc      1020
tacatggagc tgaggagcct gaggtctgac gacacggccg tgtattactg tgcgttgggg      1080
gcctttgttt actggggcca gggaaccctg gtcaccgtct cctcaggcag tactagcggt      1140
ggtggctccg ggggcggttc cggtgggggc ggcagcagcg atgttgtgat gactcagtct      1200
ccactctccc tgcccgtcac ccctggagag ccggcctcca tctcctgcag gtctagtcag      1260
agtcttgcaa acagttatgg gaacacctat ttgtcttggt acctgcagaa gccagggcag      1320
tctccacagc tcctgatcta tgggatttcc aacagatttt ctggggtccc tgacaggttc      1380
agtggcagtg gatcaggcac agattttaca ctgaaaatca gcagagtgga ggctgaggac      1440
gttggggttt attactgctt acaaggtaca catcagccgt acacgtttgg ccaggggacc      1500
aagctggaga tcaaaaccac taccccagca ccgaggccac ccaccccggc tcctaccatc      1560
gcctcccagc ctctgtccct gcgtccggag gcatgtagac ccgcagctgg tggggccgtg      1620
catacccggg gtcttgactt cgcctgcgat atctacattt gggcccctct ggctggtact      1680
tgcggggtcc tgctgctttc actcgtgatc actctttact gtaggagtaa gaggagcagg      1740
ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      1800
taccagccct atgccccacc acgcgacttc gcagcctatc gctcccgcgt gaaattcagc      1860
cgcagcgcag atgctccagc ctacaagcag gggcagaacc agctctacaa cgaactcaat      1920
cttggtcgga gagaggagta cgacgtgctg gacaagcgga gaggacggga cccagaaatg      1980
ggcgggaagc cgcgcagaaa gaatccccaa gagggcctgt acaacgagct ccaaaaggat      2040
aagatggcag aagcctatag cgagattggt atgaaagggg aacgcagaag aggcaaaggc      2100
cacgacggac tgtaccaggg actcagcacc gccaccaagg acacctatga cgctcttcac      2160
atgcaggccc tgccgcctcg ggagggaagg ggttctctcc tgacctgcgg cgatgtggag      2220
gagaaccccg gacccatgac caacaagtgt ctcctccaaa ttgctctcct gttgtgcttc      2280
tccactacag ctctttccca ggtgcagcta cagcagtcgg gcccaggact ggtgaagcct      2340
tcacacaccc tgtccctcac ctgcactgtc tctggtggct ccatcagcag tggtggttac      2400
tactggagtt ggacccgtca gcacccaggg atgggcctgg agtggattgg atacatctct      2460
tacagtggga gtatctatta cactccgtcc ctcaagagtc gacttaccat atcagtggac      2520
acgtctaaga accagttctc cctgaagctg agctctgtga ctgccgcgga cacggccgta      2580
tattactgtg cgagtttgga ttcctgggga tctaaccgtg actactgggg ccagggaacc      2640
ctggtcaccg tctcgagtgg aggtggtgga tccgaaattg tgttgacgca gtctccagcc      2700
accctgtctt tgtctccagg ggaaagagcc accctctcct gcagggccag tcagagtgtt      2760
agcagctact tagcctggta ccaacagaaa cctggccagg ctcccaggct cctcatctat      2820
gatgcatcca acagggccac tggcatccca gccaggttca gtggcagtgg gtctgggaca      2880
gacttcactc tcaccatcag cagcctagag cctgaagatt ttgcagttta ttactgtcag      2940
cagcgtagca actggccgct cactttcggc ggagggacca aggtggagat taag            2994

<210>  5
<211>  2181
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  5
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc        60
tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct       120
ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaattctat       180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat       240
ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gaggagaagt       300
gactacaggg gctactacgg tatggacgtc tggggccaag ggaccacggt caccgtctcc       360
tcaggcagta ctagcggtgg tggctccggg ggcggttccg gtgggggcgg cagcagcgaa       420
attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc       480
tcctgcaggg ccagtcagag tgttatcaac tacttagcct ggtaccaaca gaaacctggc       540
caggctccca ggctcctcat ctatgatgca tccaacaggg cctctggcat cccagccagg       600
ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa       660
gattttgcag tttattactg tcagcagcgt cgcaactggc cgctcacttt cggcggaggg       720
accaaggtgg agatcaaagg aggtggtgga tccggaggtg gtggctccgg aggtggtgga       780
tcccaggttc agctggtgca gtctggagct gaggtgaaga agcctggggc ctcagtgaag       840
gtctcctgca aggcttctgg ttacaccttt accgactttg aaatgcactg ggtgcgacag       900
gcccctggac aagggcttga gtggatggga gatattgatc ctggaactgg tgatactgcc       960
tacaatctga agttcaaggg cagagtcacc atgaccacag acacatccac gagcacagcc      1020
tacatggagc tgaggagcct gaggtctgac gacacggccg tgtattactg tgcgttgggg      1080
gcctttgttt actggggcca gggaaccctg gtcaccgtct cctcaggcag tactagcggt      1140
ggtggctccg ggggcggttc cggtgggggc ggcagcagcg atgttgtgat gactcagtct      1200
ccactctccc tgcccgtcac ccctggagag ccggcctcca tctcctgcag gtctagtcag      1260
agtcttgcaa acagttatgg gaacacctat ttgtcttggt acctgcagaa gccagggcag      1320
tctccacagc tcctgatcta tgggatttcc aacagatttt ctggggtccc tgacaggttc      1380
agtggcagtg gatcaggcac agattttaca ctgaaaatca gcagagtgga ggctgaggac      1440
gttggggttt attactgctt acaaggtaca catcagccgt acacgtttgg ccaggggacc      1500
aagctggaga tcaaaaccac taccccagca ccgaggccac ccaccccggc tcctaccatc      1560
gcctcccagc ctctgtccct gcgtccggag gcatgtagac ccgcagctgg tggggccgtg      1620
catacccggg gtcttgactt cgcctgcgat atctacattt gggcccctct ggctggtact      1680
tgcggggtcc tgctgctttc actcgtgatc actctttact gtaggagtaa gaggagcagg      1740
ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      1800
taccagccct atgccccacc acgcgacttc gcagcctatc gctcccgcgt gaaattcagc      1860
cgcagcgcag atgctccagc ctacaagcag gggcagaacc agctctacaa cgaactcaat      1920
cttggtcgga gagaggagta cgacgtgctg gacaagcgga gaggacggga cccagaaatg      1980
ggcgggaagc cgcgcagaaa gaatccccaa gagggcctgt acaacgagct ccaaaaggat      2040
aagatggcag aagcctatag cgagattggt atgaaagggg aacgcagaag aggcaaaggc      2100
cacgacggac tgtaccaggg actcagcacc gccaccaagg acacctatga cgctcttcac      2160
atgcaggccc tgccgcctcg g                                                2181

<210>  6
<211>  727
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Ser Asp Tyr Arg Gly Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu Thr 
    130                 135                 140                 
Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 
Ser Cys Arg Ala Ser Gln Ser Val Ile Asn Tyr Leu Ala Trp Tyr Gln 
                165                 170                 175     
Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         
Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 
Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     
Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            260                 265                 270         
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        275                 280                 285             
Thr Phe Thr Asp Phe Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
    290                 295                 300                 
Gly Leu Glu Trp Met Gly Asp Ile Asp Pro Gly Thr Gly Asp Thr Ala 
305                 310                 315                 320 
Tyr Asn Leu Lys Phe Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser 
                325                 330                 335     
Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr 
            340                 345                 350         
Ala Val Tyr Tyr Cys Ala Leu Gly Ala Phe Val Tyr Trp Gly Gln Gly 
        355                 360                 365             
Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser Gly 
    370                 375                 380                 
Gly Gly Ser Gly Gly Gly Gly Ser Ser Asp Val Val Met Thr Gln Ser 
385                 390                 395                 400 
Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys 
                405                 410                 415     
Arg Ser Ser Gln Ser Leu Ala Asn Ser Tyr Gly Asn Thr Tyr Leu Ser 
            420                 425                 430         
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gly 
        435                 440                 445             
Ile Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 
Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
465                 470                 475                 480 
Val Gly Val Tyr Tyr Cys Leu Gln Gly Thr His Gln Pro Tyr Thr Phe 
                485                 490                 495     
Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
            500                 505                 510         
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        515                 520                 525             
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    530                 535                 540                 
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
545                 550                 555                 560 
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
                565                 570                 575     
Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            580                 585                 590         
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        595                 600                 605             
Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    610                 615                 620                 
Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
625                 630                 635                 640 
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                645                 650                 655     
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            660                 665                 670         
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        675                 680                 685             
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    690                 695                 700                 
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
705                 710                 715                 720 
Met Gln Ala Leu Pro Pro Arg 
                725         

