<110>    Kyungpook National University Industry-Academic Cooperation Foundation
         KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL

<120>    Composition for diagnosing infectious inflammatory disease
         comprising agents detecting the expression level of Wnt11

<130>    OP21-0053/PCT

<150>    KR 10-2020-0095572
<151>    2020-07-30

<160>    4

<170>    KoPatentIn 3.0

<210>    1
<211>    354
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Human Wnt11 protein amino acid sequence


<400>    1
Met Arg Ala Arg Pro Gln Val Cys Glu Ala Leu Leu Phe Ala Leu Ala
  1               5                  10                  15 

Leu Gln Thr Gly Val Cys Tyr Gly Ile Lys Trp Leu Ala Leu Ser Lys
             20                  25                  30 

Thr Pro Ser Ala Leu Ala Leu Asn Gln Thr Gln His Cys Lys Gln Leu
         35                  40                  45 

Glu Gly Leu Val Ser Ala Gln Val Gln Leu Cys Arg Ser Asn Leu Glu
     50                  55                  60 

Leu Met His Thr Val Val His Ala Ala Arg Glu Val Met Lys Ala Cys
 65                  70                  75                  80 

Arg Arg Ala Phe Ala Asp Met Arg Trp Asn Cys Ser Ser Ile Glu Leu
                 85                  90                  95 

Ala Pro Asn Tyr Leu Leu Asp Leu Glu Arg Gly Thr Arg Glu Ser Ala
            100                 105                 110 

Phe Val Tyr Ala Leu Ser Ala Ala Ala Ile Ser His Ala Ile Ala Arg
        115                 120                 125 

Ala Cys Thr Ser Gly Asp Leu Pro Gly Cys Ser Cys Gly Pro Val Pro
    130                 135                 140 

Gly Glu Pro Pro Gly Pro Gly Asn Arg Trp Gly Gly Cys Ala Asp Asn
145                 150                 155                 160 

Leu Ser Tyr Gly Leu Leu Met Gly Ala Lys Phe Ser Asp Ala Pro Met
                165                 170                 175 

Lys Val Lys Lys Thr Gly Ser Gln Ala Asn Lys Leu Met Arg Leu His
            180                 185                 190 

Asn Ser Glu Val Gly Arg Gln Ala Leu Arg Ala Ser Leu Glu Met Lys
        195                 200                 205 

Cys Lys Cys His Gly Val Ser Gly Ser Cys Ser Ile Arg Thr Cys Trp
    210                 215                 220 

Lys Gly Leu Gln Glu Leu Gln Asp Val Ala Ala Asp Leu Lys Thr Arg
225                 230                 235                 240 

Tyr Leu Ser Ala Thr Lys Val Val His Arg Pro Met Gly Thr Arg Lys
                245                 250                 255 

His Leu Val Pro Lys Asp Leu Asp Ile Arg Pro Val Lys Asp Ser Glu
            260                 265                 270 

Leu Val Tyr Leu Gln Ser Ser Pro Asp Phe Cys Met Lys Asn Glu Lys
        275                 280                 285 

Val Gly Ser His Gly Thr Gln Asp Arg Gln Cys Asn Lys Thr Ser Asn
    290                 295                 300 

Gly Ser Asp Ser Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Pro
305                 310                 315                 320 

Tyr Thr Asp Arg Val Val Glu Arg Cys His Cys Lys Tyr His Trp Cys
                325                 330                 335 

Cys Tyr Val Thr Cys Arg Arg Cys Glu Arg Thr Val Glu Arg Tyr Val
            340                 345                 350 

Cys Lys
       


<210>    2
<211>    1743
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Human WNT11 gene sequence


<400>    2
gaggcctggg tccccgtccg ctgtgcgacc tagggggctc ctcctctccc tgggagacca         60

ggctggacac agatcccccg ctgcggcgtg caggaccagc ggcggccgtg caggcggagg        120

acttcggcgc ggctcctcct gggtgtgacc ccgggcgcgc ccgccgcgcg acgatgaggg        180

cgcggccgca ggtctgcgag gcgctgctct tcgccctggc gctccagacc ggcgtgtgct        240

atggcatcaa gtggctggcg ctgtccaaga caccatcggc cctggcactg aaccagacgc        300

aacactgcaa gcagctggag ggtctggtgt ctgcacaggt gcagctgtgc cgcagcaacc        360

tggagctcat gcacacggtg gtgcacgccg cccgcgaggt catgaaggcc tgtcgccggg        420

cctttgccga catgcgctgg aactgctcct ccattgagct cgcccccaac tatttgcttg        480

acctggagag agggacccgg gagtcggcct tcgtgtatgc gctgtcggcc gccgccatca        540

gccacgccat cgcccgggcc tgcacctccg gcgacctgcc cggctgctcc tgcggccccg        600

tcccaggctc tgcgcgcctc tctggaaatg aagtgtaagt gccatggggt gtctggctcc        660

tgctccatcc gcacctgctg gaaggggctg caggagctgc aggatgtggc tgctgacctc        720

aagacccgat acctgtcggc caccaaggta gtgcaccgac ccatgggcac ccgcaagcac        780

ctggtgccca aggacctgga tatccggcct gtgaaggact cggaactcgt ctatctgcag        840

agctcacctg acttctgcat gaagaatgag aaggtgggct cccacgggac acaagacagg        900

cagtgcaaca agacatccaa cggaagcgac agctgcgacc ttatgtgctg cgggcgtggc        960

tacaacccct acacagaccg cgtggtcgag cggtgccact gtaagtacca ctggtgctgc       1020

tacgtcacct gccgcaggtg tgagcgtacc gtggagcgct atgtctgcaa gtgaggccct       1080

gccctccgcc ccacgcagga gcgaggactc tgctcaagga ccctcagcaa ctggggccag       1140

gggcctggag acactccatg gagctctgct tgtgaattcc agatgccagg catgggaggc       1200

ggcttgtgct ttgccttcac ttggaagcca ccaggaacag aaggtctggc caccctggaa       1260

ggagggcagg acatcaaagg aaaccgacaa gattaaaaat aacttggcag cctgaggctc       1320

tggagtgccc acaggctggt gtaaggagcg gggcttggga tcggtgagac tgatacagac       1380

ttgacctttc agggccacag agaccagcct ccgggaaggg gtctgcccgc cttcttcaga       1440

atgttctgcg ggaccccctg gcccaccctg gggtctgagc ctgctgggcc caccacatgg       1500

aatcactagc ttgggttgta aatgttttct tttgtttttt gctttttctt cctttgggat       1560

gtggaagcta cagaaatatt tataaaacat agctttttct ttggggtggc acttctcaat       1620

tcctctttat atattttata tatataaata tatatgtata tatataatga tctctatttt       1680

aaaactagct ttttaagcag ctgtatgaaa taaatgctga gtgagcccca gcccgcccct       1740

gca                                                                     1743


<210>    3
<211>    365
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Human Wnt5a protein amino acid sequence


<400>    3
Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala
  1               5                  10                  15 

Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp
             20                  25                  30 

Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile
         35                  40                  45 

Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln
     50                  55                  60 

Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu
 65                  70                  75                  80 

Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg
                 85                  90                  95 

Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val
            100                 105                 110 

Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala
        115                 120                 125 

Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu
    130                 135                 140 

Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg
145                 150                 155                 160 

Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg
                165                 170                 175 

Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala
            180                 185                 190 

Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn
        195                 200                 205 

Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys
    210                 215                 220 

Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln
225                 230                 235                 240 

Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp
                245                 250                 255 

Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val
            260                 265                 270 

Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp
        275                 280                 285 

Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly
    290                 295                 300 

Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys
305                 310                 315                 320 

Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln
                325                 330                 335 

Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys
            340                 345                 350 

Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys
        355                 360                 365


<210>    4
<211>    5599
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Human Wnt5a gene sequence


<400>    4
gctccactcg cctccgtgct cctctcgccc atggaattaa ttctggctcc acttgttgct         60

cggcccagaa gtccattgga atattaagcc caggagttgc tttggggatg gctggaagtg        120

caatgtcttc caagttcttc ctagtggctt tggccatatt tttctccttc gcccaggttg        180

taattgaagc caattcttgg tggtcgctag gtatgaataa ccctgttcag atgtcagaag        240

tatatattat aggagcacag cctctctgca gccaactggc aggactttct caaggacaga        300

agaaactgtg ccacttgtat caggaccaca tgcagtacat cggagaaggc gcgaagacag        360

gcatcaaaga atgccagtat caattccgac atcgaaggtg gaactgcagc actgtggata        420

acacctctgt ttttggcagg gtgatgcaga taggcagccg cgagacggcc ttcacatacg        480

cggtgagcgc agcaggggtg gtgaacgcca tgagccgggc gtgccgcgag ggcgagctgt        540

ccacctgcgg ctgcagccgc gccgcgcgcc ccaaggacct gccgcgggac tggctctggg        600

gcggctgcgg cgacaacatc gactatggct accgctttgc caaggagttc gtggacgccc        660

gcgagcggga gcgcatccac gccaagggct cctacgagag tgctcgcatc ctcatgaacc        720

tgcacaacaa cgaggccggc cgcaggacgg tgtacaacct ggctgatgtg gcctgcaagt        780

gccatggggt gtccggctca tgtagcctga agacatgctg gctgcagctg gcagacttcc        840

gcaaggtggg tgatgccctg aaggagaagt acgacagcgc ggcggccatg cggctcaaca        900

gccggggcaa gttggtacag gtcaacagcc gcttcaactc gcccaccaca caagacctgg        960

tctacatcga ccccagccct gactactgcg tgcgcaatga gagcaccggc tcgctgggca       1020

cgcagggccg cctgtgcaac aagacgtcgg agggcatgga tggctgcgag ctcatgtgct       1080

gcggccgtgg ctacgaccag ttcaagaccg tgcagacgga gcgctgccac tgcaagttcc       1140

actggtgctg ctacgtcaag tgcaagaagt gcacggagat cgtggaccag tttgtgtgca       1200

agtagtgggt gccacccagc actcagcccc gctcccagga cccgcttatt tatagaaagt       1260

acagtgattc tggtttttgg tttttagaaa tattttttat ttttccccaa gaattgcaac       1320

cggaaccatt ttttttcctg ttaccatcta agaactctgt ggtttattat taatattata       1380

attattattt ggcaataatg ggggtgggaa ccaagaaaaa tatttatttt gtggatcttt       1440

gaaaaggtaa tacaagactt cttttgatag tatagaatga aggggaaata acacataccc       1500

taacttagct gtgtggacat ggtacacatc cagaaggtaa agaaatacat tttctttttc       1560

tcaaatatgc catcatatgg gatgggtagg ttccagttga aagagggtgg tagaaatcta       1620

ttcacaattc agcttctatg accaaaatga gttgtaaatt ctctggtgca agataaaagg       1680

tcttgggaaa acaaaacaaa acaaaacaaa cctcccttcc ccagcagggc tgctagcttg       1740

ctttctgcat tttcaaaatg ataatttaca atggaaggac aagaatgtca tattctcaag       1800

gaaaaaaggt atatcacatg tctcattctc ctcaaatatt ccatttgcag acagaccgtc       1860

atattctaat agctcatgaa atttgggcag cagggaggaa agtccccaga aattaaaaaa       1920

tttaaaactc ttatgtcaag atgttgattt gaagctgtta taagaattag gattccagat       1980

tgtaaaaaga tccccaaatg attctggaca ctagattttt ttgtttgggg aggttggctt       2040

gaacataaat gaaaatatcc tgttattttc ttagggatac ttggttagta aattataata       2100

gtaaaaataa tacatgaatc ccattcacag gttctcagcc caagcaacaa ggtaattgcg       2160

tgccattcag cactgcacca gagcagacaa cctatttgag gaaaaacagt gaaatccacc       2220

ttcctcttca cactgagccc tctctgattc ctccgtgttg tgatgtgatg ctggccacgt       2280

ttccaaacgg cagctccact gggtcccctt tggttgtagg acaggaaatg aaacattagg       2340

agctctgctt ggaaaacagt tcactactta gggatttttg tttcctaaaa cttttatttt       2400

gaggagcagt agttttctat gttttaatga cagaacttgg ctaatggaat tcacagaggt       2460

gttgcagcgt atcactgtta tgatcctgtg tttagattat ccactcatgc ttctcctatt       2520

gtactgcagg tgtaccttaa aactgttccc agtgtacttg aacagttgca tttataaggg       2580

gggaaatgtg gtttaatggt gcctgatatc tcaaagtctt ttgtacataa catatatata       2640

tatatacata tatataaata taaatataaa tatatctcat tgcagccagt gatttagatt       2700

tacagtttac tctggggtta tttctctgtc tagagcattg ttgtccttca ctgcagtcca       2760

gttgggatta ttccaaaagt tttttgagtc ttgagcttgg gctgtggccc tgctgtgatc       2820

ataccttgag cacgacgaag caaccttgtt tctgaggaag cttgagttct gactcactga       2880

aatgcgtgtt gggttgaaga tatctttttt cttttctgcc tcaccccttt gtctccaacc       2940

tccatttctg ttcactttgt ggagagggca ttacttgttc gttatagaca tggacgttaa       3000

gagatattca aaactcagaa gcatcagcaa tgtttctctt ttcttagttc attctgcaga       3060

atggaaaccc atgcctatta gaaatgacag tacttattaa ttgagtccct aaggaatatt       3120

cagcccacta catagatagc tttttttttt ttttttttaa taaggacacc tctttccaaa       3180

cagtgccatc aaatatgttc ttatctcaga cttacgttgt tttaaaagtt tggaaagata       3240

cacatctttc atacccccct taggcaggtt ggctttcata tcacctcagc caactgtggc       3300

tcttaattta ttgcataatg atattcacat cccctcagtt gcagtgaatt gtgagcaaaa       3360

gatcttgaaa gcaaaaagca ctaattagtt taaaatgtca cttttttggt ttttattata       3420

caaaaaccat gaagtacttt ttttatttgc taaatcagat tgttcctttt tagtgactca       3480

tgtttatgaa gagagttgag tttaacaatc ctagctttta aaagaaacta tttaatgtaa       3540

aatattctac atgtcattca gatattatgt atatcttcta gcctttattc tgtactttta       3600

atgtacatat ttctgtcttg cgtgatttgt atatttcact ggtttaaaaa acaaacatcg       3660

aaaggcttat gccaaatgga agatagaata taaaataaaa cgttacttgt atattggtaa       3720

gtggtttcaa ttgtccttca gataattcat gtggagattt ttggagaaac catgacggat       3780

agtttaggat gactacatgt caaagtaata aaagagtggt gaattttacc aaaaccaagc       3840

tatttggaag cttcaaaagg tttctatatg taatggaaca aaaggggaat tctcttttcc       3900

tatatatgtt ccttacaaaa aaaaaaaaaa aagaaatcaa gcagatggct taaagctggt       3960

tataggattg ctcacattct tttagcatta tgcatgtaac ttaattgttt tagagcgtgt       4020

tgctgttgta acatcccaga gaagaatgaa aaggcacatg cttttatccg tgaccagatt       4080

tttagtccaa aaaaatgtat ttttttgtgt gtttaccact gcaactattg cacctctcta       4140

tttgaattta ctgtggacca tgtgtggtgt ctctatgccc tttgaaagca gtttttataa       4200

aaagaaagcc cgggtctgca gagaatgaaa actggttgga aactaaaggt tcattgtgtt       4260

aagtgcaatt aatacaagtt attgtgcttt tcaaaaatgt acacggaaat ctggacagtg       4320

ctccacagat tgatacatta gcctttgctt tttctctttc cggataacct tgtaacatat       4380

tgaaaccttt taaggatgcc aagaatgcat tattccacaa aaaaacagca gaccaacata       4440

tagagtgttt aaaatagcat ttctgggcaa attcaaactc ttgtggttct aggactcaca       4500

tctgtttcag tttttcctca gttgtatatt gaccagtgtt ctttattgca aaaacatata       4560

cccgatttag cagtgtcagc gtattttttc ttctcatcct ggagcgtatt caagatcttc       4620

ccaatacaag aaaattaata aaaaatttat atataggcag cagcaaaaga gccatgttca       4680

aaatagtcat tatgggctca aatagaaaga agacttttaa gttttaatcc agtttatctg       4740

ttgagttctg tgagctactg acctcctgag actggcactg tgtaagtttt agttgcctac       4800

cctagctctt ttctcgtaca attttgccaa taccaagttt caatttgttt ttacaaaaca       4860

ttattcaagc cactagaatt atcaaatatg acgctatagc agagtaaata ctctgaataa       4920

gagaccggta ctagctaact ccaagagatc gttagcagca tcagtccaca aacacttagt       4980

ggcccacaat atatagagag atagaaaagg tagttataac ttgaagcatg tatttaatgc       5040

aaataggcac gaaggcacag gtctaaaata ctacattgtc actgtaagct atacttttaa       5100

aatatttatt ttttttaaag tattttctag tcttttctct ctctgtggaa tggtgaaaga       5160

gagatgccgt gttttgaaag taagatgatg aaatgaattt ttaattcaag aaacattcag       5220

aaacatagga attaaaactt agagaaatga tctaatttcc ctgttcacac aaactttaca       5280

ctttaatctg atgattggat attttatttt agtgaaacat catcttgtta gctaacttta       5340

aaaaatggat gtagaatgat taaaggttgg tatgattttt ttttaatgta tcagtttgaa       5400

cctagaatat tgaattaaaa tgctgtctca gtattttaaa agcaaaaaag gaatggagga       5460

aaattgcatc ttagaccatt tttatatgca gtgtacaatt tgctgggcta gaaatgagat       5520

aaagattatt tatttttgtt catatcttgt acttttctat taaaatcatt ttatgaaatc       5580

caaaaaaaaa aaaaaaaaa                                                    5599
