                         SEQUENCE LISTING

<110>  Ohio State Innovation Foundation
 
<120>  METHODS TO CONTROL LIPOKINE CONCENTRATIONS AND USES THEREOF

<130>  10336-791WO1

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  1365
<212>  DNA
<213>  Mus musculus

<400>  1
atgtggctgg aactcatcct ggcttctgtg ctgggctttg tcatctactg gtttgtctcc       60

cgggacaagg aggagacctt accacttgaa gatgggtggt ggggcccagg gtcaaagcca      120

tcagccaaag aagatgagag catccggccc ttcaaggtgg aaacatcaga tgaggagatc      180

aaggacttgc accagaggat agataggttc cgggcatccc cacctttgga gggcagtcgc      240

ttccactatg gcttcaactc cagctacctg aagaaagtgg tgtccttctg gaggaatgag      300

tttgactgga ggaagcaggt ggagatcctc aaccaatacc cacactttaa gaccaagatt      360

gaagggctgg acatccactt catccacgtg aaacctcccc agctgccctc aggccgcact      420

ccaaagccct tgctgatggt gcacggctgg cctggctcct tctatgagtt ctacaagatt      480

atcccactgc tgacagaccc caagacccac ggcctgagtg atgagcacgt gtttgaagtc      540

atctgtccct caattcctgg ctatggcttc tcagaggcat ccagcaagaa aggtttaaat      600

tcggtggcca ctgcgaggat cttctacaag ctgatgtcac ggctgggctt ccagaagttc      660

tacattcaag gcggcgactg ggggtctctc atctgcacca acatagccca gatggtgccc      720

aaccacgtga aaggtttgca cttgaatatg tctttcattt caagaaacat ttattccctg      780

acccctctcc tgggccaacg ttttgggaga tttcttggct acacagagaa ggatctggag      840

ctcttgtacc cattcaagga aaaggttttc tacaacatca tgagggagag tggctactta      900

cacatccagg ccaccaagcc ggacactgtg ggctgtgctc tgaatgactc tcctgtgggc      960

ctggctgcct acatcttaga gaagttctcc acctggacca agtcagaata ccgtgaactg     1020

gaggatggag gcctggagag gaagttctcc ctggaagatc tgctgactaa catcatgatc     1080

tactggacga caggaaccat tgtctcctcc cagcgcttct acaaggaaaa cttgggccag     1140

ggtgtcatgg tccatagaca tgaggggatg aaggtctttg tgcccactgg ctattcagcc     1200

ttcccttctg agatcctgca tgccccagaa aagtgggtga aggtcaagta ccccaaactc     1260

atctcctatt cctacatgga acgtgggggc cactttgctg ccttcgaaga gcccaagctt     1320

ctggcccagg acatccgcaa gttcgtgtcc ctggctgagc tgcag                     1365


<210>  2
<211>  455
<212>  PRT
<213>  Mus musculus

<400>  2

Met Trp Leu Glu Leu Ile Leu Ala Ser Val Leu Gly Phe Val Ile Tyr 
1               5                   10                  15      


Trp Phe Val Ser Arg Asp Lys Glu Glu Thr Leu Pro Leu Glu Asp Gly 
            20                  25                  30          


Trp Trp Gly Pro Gly Ser Lys Pro Ser Ala Lys Glu Asp Glu Ser Ile 
        35                  40                  45              


Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile Lys Asp Leu His 
    50                  55                  60                  


Gln Arg Ile Asp Arg Phe Arg Ala Ser Pro Pro Leu Glu Gly Ser Arg 
65                  70                  75                  80  


Phe His Tyr Gly Phe Asn Ser Ser Tyr Leu Lys Lys Val Val Ser Phe 
                85                  90                  95      


Trp Arg Asn Glu Phe Asp Trp Arg Lys Gln Val Glu Ile Leu Asn Gln 
            100                 105                 110         


Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile 
        115                 120                 125             


His Val Lys Pro Pro Gln Leu Pro Ser Gly Arg Thr Pro Lys Pro Leu 
    130                 135                 140                 


Leu Met Val His Gly Trp Pro Gly Ser Phe Tyr Glu Phe Tyr Lys Ile 
145                 150                 155                 160 


Ile Pro Leu Leu Thr Asp Pro Lys Thr His Gly Leu Ser Asp Glu His 
                165                 170                 175     


Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Phe Ser Glu 
            180                 185                 190         


Ala Ser Ser Lys Lys Gly Leu Asn Ser Val Ala Thr Ala Arg Ile Phe 
        195                 200                 205             


Tyr Lys Leu Met Ser Arg Leu Gly Phe Gln Lys Phe Tyr Ile Gln Gly 
    210                 215                 220                 


Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Ile Ala Gln Met Val Pro 
225                 230                 235                 240 


Asn His Val Lys Gly Leu His Leu Asn Met Ser Phe Ile Ser Arg Asn 
                245                 250                 255     


Ile Tyr Ser Leu Thr Pro Leu Leu Gly Gln Arg Phe Gly Arg Phe Leu 
            260                 265                 270         


Gly Tyr Thr Glu Lys Asp Leu Glu Leu Leu Tyr Pro Phe Lys Glu Lys 
        275                 280                 285             


Val Phe Tyr Asn Ile Met Arg Glu Ser Gly Tyr Leu His Ile Gln Ala 
    290                 295                 300                 


Thr Lys Pro Asp Thr Val Gly Cys Ala Leu Asn Asp Ser Pro Val Gly 
305                 310                 315                 320 


Leu Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Lys Ser Glu 
                325                 330                 335     


Tyr Arg Glu Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Glu 
            340                 345                 350         


Asp Leu Leu Thr Asn Ile Met Ile Tyr Trp Thr Thr Gly Thr Ile Val 
        355                 360                 365             


Ser Ser Gln Arg Phe Tyr Lys Glu Asn Leu Gly Gln Gly Val Met Val 
    370                 375                 380                 


His Arg His Glu Gly Met Lys Val Phe Val Pro Thr Gly Tyr Ser Ala 
385                 390                 395                 400 


Phe Pro Ser Glu Ile Leu His Ala Pro Glu Lys Trp Val Lys Val Lys 
                405                 410                 415     


Tyr Pro Lys Leu Ile Ser Tyr Ser Tyr Met Glu Arg Gly Gly His Phe 
            420                 425                 430         


Ala Ala Phe Glu Glu Pro Lys Leu Leu Ala Gln Asp Ile Arg Lys Phe 
        435                 440                 445             


Val Ser Leu Ala Glu Leu Gln 
    450                 455 


<210>  3
<211>  1662
<212>  DNA
<213>  Mus musculus

<400>  3
atggcgctgc gtgtagccgc gttcgacctt gacggagtgc tggccctccc ctctatcgcc       60

ggggctttcc gccgcagcga agaggccctg gcactgccta gagacttcct gcttggtgcg      120

taccagacgg aattcccaga gggacccact gagcaactca tgaaagggaa gatcacattt      180

tcgcagtggg taccactcat ggatgaaagc tacaggaagt cctccaaagc ctgtggagcc      240

aatctacctg agaatttctc cataagtcaa atattcagcc aagctatggc agcaagaagc      300

atcaaccgcc ccatgcttca ggcagccatt gctctcaaaa agaaaggatt cacaacatgc      360

attgtcacca acaactggct ggacgacgga gacaagagag acagcctggc ccagatgatg      420

tgtgagctga gccaacactt tgacttcctg atagagtcct gtcaggttgg gatgatcaag      480

cctgagcctc agatctacaa ttttttactg gataccctga aggcaaaacc caatgaggtt      540

gttttcctag atgactttgg aagtaatctg aagccagccc gtgacatggg gatggttacc      600

atcctggtcc acaacacagc ctccgctctg agagaactgg agaaggtcac agggacacag      660

tttcctgagg ccccactgcc agtcccatgc aatccaaatg acgtcagcca tggatatgtg      720

acagtgaagc cagggatccg cctgcatttt gtggagatgg gctctggccc tgccctatgc      780

ctttgccatg ggtttcctga gagctggttt tcttggaggt accagatccc tgctctggcc      840

caggcaggct ttcgtgttct ggctatagac atgaaaggct atggagactc atcttctcct      900

cctgaaatag aagaatatgc catggaattg ctgtgtaagg agatggtgac attcctggat      960

aagctgggaa tccctcaagc agtgttcatt ggccatgact gggctggtgt gatggtgtgg     1020

aacatggctc tcttctaccc tgagagagtg agggctgtgg ccagtttgaa cacgccgttt     1080

atgccaccag atcctgatgt gtctcccatg aaagttatcc gatctatccc agttttcaat     1140

tatcagctgt actttcaaga accaggagtg gccgaggctg aactggagaa gaacatgagt     1200

cggactttca aaagcttctt ccgagccagt gatgagacag gtttcatcgc tgtgcataaa     1260

gccactgaaa tagggggaat ccttgtgaat actccagaag atcccaacct cagcaaaatt     1320

actactgagg aagaaataga gttttacata cagcagttca agaagactgg cttcagaggt     1380

cctctgaact ggtaccggaa cacagaaaga aactggaagt ggagctgtaa agggttggga     1440

cgaaagatct tggtcccagc cctgatggtc acagctgaga aggacattgt actccgtcct     1500

gaaatgtcca agaacatgga aaagtggatc cctttcctga aaaggggaca cattgaagac     1560

tgtggtcact ggacacagat agagaaacca actgaggtga accagattct catcaagtgg     1620

ctgcagactg aagtccagaa cccatcagtg acctccaaga tt                        1662


<210>  4
<211>  554
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Leu Arg Val Ala Ala Phe Asp Leu Asp Gly Val Leu Ala Leu 
1               5                   10                  15      


Pro Ser Ile Ala Gly Ala Phe Arg Arg Ser Glu Glu Ala Leu Ala Leu 
            20                  25                  30          


Pro Arg Asp Phe Leu Leu Gly Ala Tyr Gln Thr Glu Phe Pro Glu Gly 
        35                  40                  45              


Pro Thr Glu Gln Leu Met Lys Gly Lys Ile Thr Phe Ser Gln Trp Val 
    50                  55                  60                  


Pro Leu Met Asp Glu Ser Tyr Arg Lys Ser Ser Lys Ala Cys Gly Ala 
65                  70                  75                  80  


Asn Leu Pro Glu Asn Phe Ser Ile Ser Gln Ile Phe Ser Gln Ala Met 
                85                  90                  95      


Ala Ala Arg Ser Ile Asn Arg Pro Met Leu Gln Ala Ala Ile Ala Leu 
            100                 105                 110         


Lys Lys Lys Gly Phe Thr Thr Cys Ile Val Thr Asn Asn Trp Leu Asp 
        115                 120                 125             


Asp Gly Asp Lys Arg Asp Ser Leu Ala Gln Met Met Cys Glu Leu Ser 
    130                 135                 140                 


Gln His Phe Asp Phe Leu Ile Glu Ser Cys Gln Val Gly Met Ile Lys 
145                 150                 155                 160 


Pro Glu Pro Gln Ile Tyr Asn Phe Leu Leu Asp Thr Leu Lys Ala Lys 
                165                 170                 175     


Pro Asn Glu Val Val Phe Leu Asp Asp Phe Gly Ser Asn Leu Lys Pro 
            180                 185                 190         


Ala Arg Asp Met Gly Met Val Thr Ile Leu Val His Asn Thr Ala Ser 
        195                 200                 205             


Ala Leu Arg Glu Leu Glu Lys Val Thr Gly Thr Gln Phe Pro Glu Ala 
    210                 215                 220                 


Pro Leu Pro Val Pro Cys Asn Pro Asn Asp Val Ser His Gly Tyr Val 
225                 230                 235                 240 


Thr Val Lys Pro Gly Ile Arg Leu His Phe Val Glu Met Gly Ser Gly 
                245                 250                 255     


Pro Ala Leu Cys Leu Cys His Gly Phe Pro Glu Ser Trp Phe Ser Trp 
            260                 265                 270         


Arg Tyr Gln Ile Pro Ala Leu Ala Gln Ala Gly Phe Arg Val Leu Ala 
        275                 280                 285             


Ile Asp Met Lys Gly Tyr Gly Asp Ser Ser Ser Pro Pro Glu Ile Glu 
    290                 295                 300                 


Glu Tyr Ala Met Glu Leu Leu Cys Lys Glu Met Val Thr Phe Leu Asp 
305                 310                 315                 320 


Lys Leu Gly Ile Pro Gln Ala Val Phe Ile Gly His Asp Trp Ala Gly 
                325                 330                 335     


Val Met Val Trp Asn Met Ala Leu Phe Tyr Pro Glu Arg Val Arg Ala 
            340                 345                 350         


Val Ala Ser Leu Asn Thr Pro Phe Met Pro Pro Asp Pro Asp Val Ser 
        355                 360                 365             


Pro Met Lys Val Ile Arg Ser Ile Pro Val Phe Asn Tyr Gln Leu Tyr 
    370                 375                 380                 


Phe Gln Glu Pro Gly Val Ala Glu Ala Glu Leu Glu Lys Asn Met Ser 
385                 390                 395                 400 


Arg Thr Phe Lys Ser Phe Phe Arg Ala Ser Asp Glu Thr Gly Phe Ile 
                405                 410                 415     


Ala Val His Lys Ala Thr Glu Ile Gly Gly Ile Leu Val Asn Thr Pro 
            420                 425                 430         


Glu Asp Pro Asn Leu Ser Lys Ile Thr Thr Glu Glu Glu Ile Glu Phe 
        435                 440                 445             


Tyr Ile Gln Gln Phe Lys Lys Thr Gly Phe Arg Gly Pro Leu Asn Trp 
    450                 455                 460                 


Tyr Arg Asn Thr Glu Arg Asn Trp Lys Trp Ser Cys Lys Gly Leu Gly 
465                 470                 475                 480 


Arg Lys Ile Leu Val Pro Ala Leu Met Val Thr Ala Glu Lys Asp Ile 
                485                 490                 495     


Val Leu Arg Pro Glu Met Ser Lys Asn Met Glu Lys Trp Ile Pro Phe 
            500                 505                 510         


Leu Lys Arg Gly His Ile Glu Asp Cys Gly His Trp Thr Gln Ile Glu 
        515                 520                 525             


Lys Pro Thr Glu Val Asn Gln Ile Leu Ile Lys Trp Leu Gln Thr Glu 
    530                 535                 540                 


Val Gln Asn Pro Ser Val Thr Ser Lys Ile 
545                 550                 


<210>  5
<211>  1272
<212>  DNA
<213>  Mus musculus

<400>  5
atgagaggtg gcagtatctg tccgagccgc gcatctgttt cctcgaccgg tccagtggac       60

tccgatagca cggtggaatc ccaaaacaaa ggtggtgggc tgctggcgcc agcacccctg      120

gctcagtctc ccgaccacgg cggctctgta gtcgtcccag agcgcaagga tatgccggag      180

tttgtggtga cagcgctact cgcaccctca cgcctctcgc tgaagctgct gcgagcgctg      240

gtgatgagcc tggtgtactt ggctgccttg gtggccgcgt ttgtctacag ctgcatcgcg      300

ctcacccatg tgatgtgccg tcctcgcagg ggctgctgcg gccgccagag gttgtctccc      360

ccagagtgcc tgagagaccc cacgctgggc gagcattgct ttctaaccct cagggtgagt      420

gttcctcccg tgaagagttc cggcctgcgt ctgcactatg tctctgctgg tcatggcaat      480

gggccactca tgctatttct gcatggcttc ccagagaact ggttcagctg gcgctaccag      540

ctgcgagagt ttcagagcca tttccatgtc gtggctgtag acatgcgtgg ttatagtccc      600

tctgatgctc caaaggaagt ggattgttac accattgact tgttgttgga tgacatcaag      660

gataccatcc taggcctggg gtactccaag tgcatcctcg tgagccacga ctggggggcc      720

tcccttgcct gggagttctc catctactac ccatccctag tggagcgtat ggttgtggcc      780

aatggtcctc ccatgtcagt gatccaagaa tactcaatcc accacatcgg ccagatattc      840

cgatcaaact acatgttcct gttccagctt ccctggctgc cagagaagct gttgtctatg      900

tctgacttcc agattctcaa agacacattc actcaccgca agaacggcat cccaggactg      960

actccttctg aacttgaagc attcctttat cacttctcac aacctggatg cctcactggg     1020

cccatcaact actacaggaa cgtgttcagg aacttccccc tggagcccaa gaaactgtca     1080

acacccacgc tgttgctgtg gggggaaaaa gacttcgcct tccagcaggg gctggtggaa     1140

gccattggaa gacactttgt gcccggccgg ttggaaagcc acattttgcc aggcagtggg     1200

cactggattc cacagagcca tcctcaggag atgcatcagt acatgtgggc cttcttgcaa     1260

gacctgctgg gc                                                         1272


<210>  6
<211>  424
<212>  PRT
<213>  Mus musculus

<400>  6

Met Arg Gly Gly Ser Ile Cys Pro Ser Arg Ala Ser Val Ser Ser Thr 
1               5                   10                  15      


Gly Pro Val Asp Ser Asp Ser Thr Val Glu Ser Gln Asn Lys Gly Gly 
            20                  25                  30          


Gly Leu Leu Ala Pro Ala Pro Leu Ala Gln Ser Pro Asp His Gly Gly 
        35                  40                  45              


Ser Val Val Val Pro Glu Arg Lys Asp Met Pro Glu Phe Val Val Thr 
    50                  55                  60                  


Ala Leu Leu Ala Pro Ser Arg Leu Ser Leu Lys Leu Leu Arg Ala Leu 
65                  70                  75                  80  


Val Met Ser Leu Val Tyr Leu Ala Ala Leu Val Ala Ala Phe Val Tyr 
                85                  90                  95      


Ser Cys Ile Ala Leu Thr His Val Met Cys Arg Pro Arg Arg Gly Cys 
            100                 105                 110         


Cys Gly Arg Gln Arg Leu Ser Pro Pro Glu Cys Leu Arg Asp Pro Thr 
        115                 120                 125             


Leu Gly Glu His Cys Phe Leu Thr Leu Arg Val Ser Val Pro Pro Val 
    130                 135                 140                 


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly His Gly Asn 
145                 150                 155                 160 


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
                165                 170                 175     


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser His Phe His Val Val Ala 
            180                 185                 190         


Val Asp Met Arg Gly Tyr Ser Pro Ser Asp Ala Pro Lys Glu Val Asp 
        195                 200                 205             


Cys Tyr Thr Ile Asp Leu Leu Leu Asp Asp Ile Lys Asp Thr Ile Leu 
    210                 215                 220                 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ser His Asp Trp Gly Ala 
225                 230                 235                 240 


Ser Leu Ala Trp Glu Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
                245                 250                 255     


Met Val Val Ala Asn Gly Pro Pro Met Ser Val Ile Gln Glu Tyr Ser 
            260                 265                 270         


Ile His His Ile Gly Gln Ile Phe Arg Ser Asn Tyr Met Phe Leu Phe 
        275                 280                 285             


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
    290                 295                 300                 


Ile Leu Lys Asp Thr Phe Thr His Arg Lys Asn Gly Ile Pro Gly Leu 
305                 310                 315                 320 


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr His Phe Ser Gln Pro Gly 
                325                 330                 335     


Cys Leu Thr Gly Pro Ile Asn Tyr Tyr Arg Asn Val Phe Arg Asn Phe 
            340                 345                 350         


Pro Leu Glu Pro Lys Lys Leu Ser Thr Pro Thr Leu Leu Leu Trp Gly 
        355                 360                 365             


Glu Lys Asp Phe Ala Phe Gln Gln Gly Leu Val Glu Ala Ile Gly Arg 
    370                 375                 380                 


His Phe Val Pro Gly Arg Leu Glu Ser His Ile Leu Pro Gly Ser Gly 
385                 390                 395                 400 


His Trp Ile Pro Gln Ser His Pro Gln Glu Met His Gln Tyr Met Trp 
                405                 410                 415     


Ala Phe Leu Gln Asp Leu Leu Gly 
            420                 


<210>  7
<211>  1077
<212>  DNA
<213>  Mus musculus

<400>  7
atggccccgc cgcgcccgcc ccgcctgctg cccgcgctgc gcgccctgct ctactggtcc       60

ctggtgtacg gctactgcgg gctgtgcgcc tccgtccacc tgctcaaact tttgtggagc      120

atcggtaggg cgccggcgca gaccttccgc cgggcggccc gggccaaccc tccggcgtgc      180

ctgaacgacc cctccttagg gactcactgc tacgtgcgca tcaaggactc cgggttaaga      240

tttcactatg ttgctgctgg agaaaggggc aaaccgctca tgctgctgct tcatggattt      300

ccagaattct ggtattcttg gcgccatcaa ctgagagaat ttaaaagcga atacagggtt      360

gttgcattgg atttgagagg ttatggagag tctgatgcac ctgctcatca agagagttac      420

aaactggact gtctaattgc agacataaag gatattttgg actccttagg gtatagcaaa      480

tgtgtcctga tcggccatga ctggggaggc atgattgcct ggctgattgc tgtctgctac      540

cctgagatga taatgaagct cattgttatt aacttcccac atccaagtgt atttacagag      600

tatatactgc ggcatcctgc ccagctgttc agatccagct tttattactt cttccaaata      660

ccacgcttcc cagaatttat gttctcaatt aatgatttta aggctttgaa acatctgttt      720

accagtcaga gtactggcat tggaaggaaa ggacgccagc tgacaacaga agatctagaa      780

gcttacgttt atgtcttttc tcagcctgga gcactaagtg gtccaattaa ccattatcga      840

aacattttca gctgcctgcc tctcaaacat cacatggtga ccaccccaac actgcttctg      900

tggggagagg aagatgcgtt tatggaggta gagatggccg aggtcacaaa gatttatgtt      960

aaaaactatt tcagactcac cattttgtca gaaggtagcc actggcttca gcaagaccag     1020

cctgacatag tgaatggact gatatgggca ttcctgaagg aagaaacaag gagagac        1077


<210>  8
<211>  359
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Pro Pro Arg Pro Pro Arg Leu Leu Pro Ala Leu Arg Ala Leu 
1               5                   10                  15      


Leu Tyr Trp Ser Leu Val Tyr Gly Tyr Cys Gly Leu Cys Ala Ser Val 
            20                  25                  30          


His Leu Leu Lys Leu Leu Trp Ser Ile Gly Arg Ala Pro Ala Gln Thr 
        35                  40                  45              


Phe Arg Arg Ala Ala Arg Ala Asn Pro Pro Ala Cys Leu Asn Asp Pro 
    50                  55                  60                  


Ser Leu Gly Thr His Cys Tyr Val Arg Ile Lys Asp Ser Gly Leu Arg 
65                  70                  75                  80  


Phe His Tyr Val Ala Ala Gly Glu Arg Gly Lys Pro Leu Met Leu Leu 
                85                  90                  95      


Leu His Gly Phe Pro Glu Phe Trp Tyr Ser Trp Arg His Gln Leu Arg 
            100                 105                 110         


Glu Phe Lys Ser Glu Tyr Arg Val Val Ala Leu Asp Leu Arg Gly Tyr 
        115                 120                 125             


Gly Glu Ser Asp Ala Pro Ala His Gln Glu Ser Tyr Lys Leu Asp Cys 
    130                 135                 140                 


Leu Ile Ala Asp Ile Lys Asp Ile Leu Asp Ser Leu Gly Tyr Ser Lys 
145                 150                 155                 160 


Cys Val Leu Ile Gly His Asp Trp Gly Gly Met Ile Ala Trp Leu Ile 
                165                 170                 175     


Ala Val Cys Tyr Pro Glu Met Ile Met Lys Leu Ile Val Ile Asn Phe 
            180                 185                 190         


Pro His Pro Ser Val Phe Thr Glu Tyr Ile Leu Arg His Pro Ala Gln 
        195                 200                 205             


Leu Phe Arg Ser Ser Phe Tyr Tyr Phe Phe Gln Ile Pro Arg Phe Pro 
    210                 215                 220                 


Glu Phe Met Phe Ser Ile Asn Asp Phe Lys Ala Leu Lys His Leu Phe 
225                 230                 235                 240 


Thr Ser Gln Ser Thr Gly Ile Gly Arg Lys Gly Arg Gln Leu Thr Thr 
                245                 250                 255     


Glu Asp Leu Glu Ala Tyr Val Tyr Val Phe Ser Gln Pro Gly Ala Leu 
            260                 265                 270         


Ser Gly Pro Ile Asn His Tyr Arg Asn Ile Phe Ser Cys Leu Pro Leu 
        275                 280                 285             


Lys His His Met Val Thr Thr Pro Thr Leu Leu Leu Trp Gly Glu Glu 
    290                 295                 300                 


Asp Ala Phe Met Glu Val Glu Met Ala Glu Val Thr Lys Ile Tyr Val 
305                 310                 315                 320 


Lys Asn Tyr Phe Arg Leu Thr Ile Leu Ser Glu Gly Ser His Trp Leu 
                325                 330                 335     


Gln Gln Asp Gln Pro Asp Ile Val Asn Gly Leu Ile Trp Ala Phe Leu 
            340                 345                 350         


Lys Glu Glu Thr Arg Arg Asp 
        355                 


<210>  9
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Trp Leu Glu Ile Leu Leu Thr Ser Val Leu Gly Phe Ala Ile Tyr 
1               5                   10                  15      


Trp Phe Ile Ser Arg Asp Lys Glu Glu Thr Leu Pro Leu Glu Asp Gly 
            20                  25                  30          


Trp Trp Gly Pro Gly Thr Arg Ser Ala Ala Arg Glu Asp Asp Ser Ile 
        35                  40                  45              


Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile His Asp Leu His 
    50                  55                  60                  


Gln Arg Ile Asp Lys Phe Arg Phe Thr Pro Pro Leu Glu Asp Ser Cys 
65                  70                  75                  80  


Phe His Tyr Gly Phe Asn Ser Asn Tyr Leu Lys Lys Val Ile Ser Tyr 
                85                  90                  95      


Trp Arg Asn Glu Phe Asp Trp Lys Lys Gln Val Glu Ile Leu Asn Arg 
            100                 105                 110         


Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile 
        115                 120                 125             


His Val Lys Pro Pro Gln Leu Pro Ala Gly His Thr Pro Lys Pro Leu 
    130                 135                 140                 


Leu Met Val His Gly Trp Pro Gly Ser Phe Tyr Glu Phe Tyr Lys Ile 
145                 150                 155                 160 


Ile Pro Leu Leu Thr Asp Pro Lys Asn His Gly Leu Ser Asp Glu His 
                165                 170                 175     


Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Phe Ser Glu 
            180                 185                 190         


Ala Ser Ser Lys Lys Gly Phe Asn Ser Val Ala Thr Ala Arg Ile Phe 
        195                 200                 205             


Tyr Lys Leu Met Leu Arg Leu Gly Phe Gln Glu Phe Tyr Ile Gln Gly 
    210                 215                 220                 


Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Met Ala Gln Leu Val Pro 
225                 230                 235                 240 


Ser His Val Lys Gly Leu His Leu Asn Met Ala Leu Val Leu Ser Asn 
                245                 250                 255     


Phe Ser Thr Leu Thr Leu Leu Leu Gly Gln Arg Phe Gly Arg Phe Leu 
            260                 265                 270         


Gly Leu Thr Glu Arg Asp Val Glu Leu Leu Tyr Pro Val Lys Glu Lys 
        275                 280                 285             


Val Phe Tyr Ser Leu Met Arg Glu Ser Gly Tyr Met His Ile Gln Cys 
    290                 295                 300                 


Thr Lys Pro Asp Thr Val Gly Ser Ala Leu Asn Asp Ser Pro Val Gly 
305                 310                 315                 320 


Leu Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Asn Thr Glu 
                325                 330                 335     


Phe Arg Tyr Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Asp 
            340                 345                 350         


Asp Leu Leu Thr Asn Val Met Leu Tyr Trp Thr Thr Gly Thr Ile Ile 
        355                 360                 365             


Ser Ser Gln Arg Phe Tyr Lys Glu Asn Leu Gly Gln Gly Trp Met Thr 
    370                 375                 380                 


Gln Lys His Glu Arg Met Lys Val Tyr Val Pro Thr Gly Phe Ser Ala 
385                 390                 395                 400 


Phe Pro Phe Glu Leu Leu His Thr Pro Glu Lys Trp Val Arg Phe Lys 
                405                 410                 415     


Tyr Pro Lys Leu Ile Ser Tyr Ser Tyr Met Val Arg Gly Gly His Phe 
            420                 425                 430         


Ala Ala Phe Glu Glu Pro Glu Leu Leu Ala Gln Asp Ile Arg Lys Phe 
        435                 440                 445             


Leu Ser Val Leu Glu Arg Gln 
    450                 455 


<210>  10
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Leu Arg Ala Ala Val Phe Asp Leu Asp Gly Val Leu Ala Leu 
1               5                   10                  15      


Pro Ala Val Phe Gly Val Leu Gly Arg Thr Glu Glu Ala Leu Ala Leu 
            20                  25                  30          


Pro Arg Gly Leu Leu Asn Asp Ala Phe Gln Lys Gly Gly Pro Glu Gly 
        35                  40                  45              


Ala Thr Thr Arg Leu Met Lys Gly Glu Ile Thr Leu Ser Gln Trp Ile 
    50                  55                  60                  


Pro Leu Met Glu Glu Asn Cys Arg Lys Cys Ser Glu Thr Ala Lys Val 
65                  70                  75                  80  


Cys Leu Pro Lys Asn Phe Ser Ile Lys Glu Ile Phe Asp Lys Ala Ile 
                85                  90                  95      


Ser Ala Arg Lys Ile Asn Arg Pro Met Leu Gln Ala Ala Leu Met Leu 
            100                 105                 110         


Arg Lys Lys Gly Phe Thr Thr Ala Ile Leu Thr Asn Thr Trp Leu Asp 
        115                 120                 125             


Asp Arg Ala Glu Arg Asp Gly Leu Ala Gln Leu Met Cys Glu Leu Lys 
    130                 135                 140                 


Met His Phe Asp Phe Leu Ile Glu Ser Cys Gln Val Gly Met Val Lys 
145                 150                 155                 160 


Pro Glu Pro Gln Ile Tyr Lys Phe Leu Leu Asp Thr Leu Lys Ala Ser 
                165                 170                 175     


Pro Ser Glu Val Val Phe Leu Asp Asp Ile Gly Ala Asn Leu Lys Pro 
            180                 185                 190         


Ala Arg Asp Leu Gly Met Val Thr Ile Leu Val Gln Asp Thr Asp Thr 
        195                 200                 205             


Ala Leu Lys Glu Leu Glu Lys Val Thr Gly Ile Gln Leu Leu Asn Thr 
    210                 215                 220                 


Pro Ala Pro Leu Pro Thr Ser Cys Asn Pro Ser Asp Met Ser His Gly 
225                 230                 235                 240 


Tyr Val Thr Val Lys Pro Arg Val Arg Leu His Phe Val Glu Leu Gly 
                245                 250                 255     


Ser Gly Pro Ala Val Cys Leu Cys His Gly Phe Pro Glu Ser Trp Tyr 
            260                 265                 270         


Ser Trp Arg Tyr Gln Ile Pro Ala Leu Ala Gln Ala Gly Tyr Arg Val 
        275                 280                 285             


Leu Ala Met Asp Met Lys Gly Tyr Gly Glu Ser Ser Ala Pro Pro Glu 
    290                 295                 300                 


Ile Glu Glu Tyr Cys Met Glu Val Leu Cys Lys Glu Met Val Thr Phe 
305                 310                 315                 320 


Leu Asp Lys Leu Gly Leu Ser Gln Ala Val Phe Ile Gly His Asp Trp 
                325                 330                 335     


Gly Gly Met Leu Val Trp Tyr Met Ala Leu Phe Tyr Pro Glu Arg Val 
            340                 345                 350         


Arg Ala Val Ala Ser Leu Asn Thr Pro Phe Ile Pro Ala Asn Pro Asn 
        355                 360                 365             


Met Ser Pro Leu Glu Ser Ile Lys Ala Asn Pro Val Phe Asp Tyr Gln 
    370                 375                 380                 


Leu Tyr Phe Gln Glu Pro Gly Val Ala Glu Ala Glu Leu Glu Gln Asn 
385                 390                 395                 400 


Leu Ser Arg Thr Phe Lys Ser Leu Phe Arg Ala Ser Asp Glu Ser Val 
                405                 410                 415     


Leu Ser Met His Lys Val Cys Glu Ala Gly Gly Leu Phe Val Asn Ser 
            420                 425                 430         


Pro Glu Glu Pro Ser Leu Ser Arg Met Val Thr Glu Glu Glu Ile Gln 
        435                 440                 445             


Phe Tyr Val Gln Gln Phe Lys Lys Ser Gly Phe Arg Gly Pro Leu Asn 
    450                 455                 460                 


Trp Tyr Arg Asn Met Glu Arg Asn Trp Lys Trp Ala Cys Lys Ser Leu 
465                 470                 475                 480 


Gly Arg Lys Ile Leu Ile Pro Ala Leu Met Val Thr Ala Glu Lys Asp 
                485                 490                 495     


Phe Val Leu Val Pro Gln Met Ser Gln His Met Glu Asp Trp Ile Pro 
            500                 505                 510         


His Leu Lys Arg Gly His Ile Glu Asp Cys Gly His Trp Thr Gln Met 
        515                 520                 525             


Asp Lys Pro Thr Glu Val Asn Gln Ile Leu Ile Lys Trp Leu Asp Ser 
    530                 535                 540                 


Asp Ala Arg Asn Pro Pro Val Val Ser Lys Met 
545                 550                 555 


<210>  11
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Glu Leu Val Val Thr Ala Leu Leu Ala Pro Ser Arg Leu Ser 
1               5                   10                  15      


Leu Lys Leu Leu Arg Ala Phe Met Trp Ser Leu Val Phe Ser Val Ala 
            20                  25                  30          


Leu Val Ala Ala Ala Val Tyr Gly Cys Ile Ala Leu Thr His Val Leu 
        35                  40                  45              


Cys Arg Pro Arg Arg Gly Cys Cys Gly Arg Arg Arg Ser Ala Ser Pro 
    50                  55                  60                  


Ala Cys Leu Ser Asp Pro Ser Leu Gly Glu His Gly Phe Leu Asn Leu 
65                  70                  75                  80  


Lys Ser Ser Gly Leu Arg Leu His Tyr Val Ser Ala Gly Arg Gly Asn 
                85                  90                  95      


Gly Pro Leu Met Leu Phe Leu His Gly Phe Pro Glu Asn Trp Phe Ser 
            100                 105                 110         


Trp Arg Tyr Gln Leu Arg Glu Phe Gln Ser Arg Phe His Val Val Ala 
        115                 120                 125             


Val Asp Leu Arg Gly Tyr Gly Pro Ser Asp Ala Pro Arg Asp Val Asp 
    130                 135                 140                 


Cys Tyr Thr Ile Asp Leu Leu Leu Val Asp Ile Lys Asp Val Ile Leu 
145                 150                 155                 160 


Gly Leu Gly Tyr Ser Lys Cys Ile Leu Val Ala His Asp Trp Gly Ala 
                165                 170                 175     


Leu Leu Ala Trp His Phe Ser Ile Tyr Tyr Pro Ser Leu Val Glu Arg 
            180                 185                 190         


Met Val Val Val Ser Gly Ala Pro Met Ser Val Tyr Gln Asp Tyr Ser 
        195                 200                 205             


Leu His His Ile Ser Gln Phe Phe Arg Ser His Tyr Met Phe Leu Phe 
    210                 215                 220                 


Gln Leu Pro Trp Leu Pro Glu Lys Leu Leu Ser Met Ser Asp Phe Gln 
225                 230                 235                 240 


Ile Leu Lys Thr Thr Leu Thr His Arg Lys Thr Gly Ile Pro Cys Leu 
                245                 250                 255     


Thr Pro Ser Glu Leu Glu Ala Phe Leu Tyr Asn Phe Ser Gln Pro Gly 
            260                 265                 270         


Gly Leu Thr Gly Pro Leu Asn Tyr Tyr Arg Asn Leu Phe Arg Asn Phe 
        275                 280                 285             


Pro Leu Glu Pro Gln Glu Leu Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Lys Asp Thr Tyr Leu Glu Leu Gly Leu Val Glu Ala Ile Gly Ser 
305                 310                 315                 320 


Arg Phe Val Pro Gly Arg Leu Glu Ala His Ile Leu Pro Gly Ile Gly 
                325                 330                 335     


His Trp Ile Pro Gln Ser Asn Pro Gln Glu Met His Gln Tyr Met Trp 
            340                 345                 350         


Ala Phe Leu Gln Asp Leu Leu Asp 
        355                 360 


<210>  12
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Arg Leu Arg Asp Cys Leu Pro Arg Leu Met Leu Thr Leu Arg 
1               5                   10                  15      


Ser Leu Leu Phe Trp Ser Leu Val Tyr Cys Tyr Cys Gly Leu Cys Ala 
            20                  25                  30          


Ser Ile His Leu Leu Lys Leu Leu Trp Ser Leu Gly Lys Gly Pro Ala 
        35                  40                  45              


Gln Thr Phe Arg Arg Pro Ala Arg Glu His Pro Pro Ala Cys Leu Ser 
    50                  55                  60                  


Asp Pro Ser Leu Gly Thr His Cys Tyr Val Arg Ile Lys Asp Ser Gly 
65                  70                  75                  80  


Leu Arg Phe His Tyr Val Ala Ala Gly Glu Arg Gly Lys Pro Leu Met 
                85                  90                  95      


Leu Leu Leu His Gly Phe Pro Glu Phe Trp Tyr Ser Trp Arg Tyr Gln 
            100                 105                 110         


Leu Arg Glu Phe Lys Ser Glu Tyr Arg Val Val Ala Leu Asp Leu Arg 
        115                 120                 125             


Gly Tyr Gly Glu Thr Asp Ala Pro Ile His Arg Gln Asn Tyr Lys Leu 
    130                 135                 140                 


Asp Cys Leu Ile Thr Asp Ile Lys Asp Ile Leu Asp Ser Leu Gly Tyr 
145                 150                 155                 160 


Ser Lys Cys Val Leu Ile Gly His Asp Trp Gly Gly Met Ile Ala Trp 
                165                 170                 175     


Leu Ile Ala Ile Cys Tyr Pro Glu Met Val Met Lys Leu Ile Val Ile 
            180                 185                 190         


Asn Phe Pro His Pro Asn Val Phe Thr Glu Tyr Ile Leu Arg His Pro 
        195                 200                 205             


Ala Gln Leu Leu Lys Ser Ser Tyr Tyr Tyr Phe Phe Gln Ile Pro Trp 
    210                 215                 220                 


Phe Pro Glu Phe Met Phe Ser Ile Asn Asp Phe Lys Val Leu Lys His 
225                 230                 235                 240 


Leu Phe Thr Ser His Ser Thr Gly Ile Gly Arg Lys Gly Cys Gln Leu 
                245                 250                 255     


Thr Thr Glu Asp Leu Glu Ala Tyr Ile Tyr Val Phe Ser Gln Pro Gly 
            260                 265                 270         


Ala Leu Ser Gly Pro Ile Asn His Tyr Arg Asn Ile Phe Ser Cys Leu 
        275                 280                 285             


Pro Leu Lys His His Met Val Thr Thr Pro Thr Leu Leu Leu Trp Gly 
    290                 295                 300                 


Glu Asn Asp Ala Phe Met Glu Val Glu Met Ala Glu Val Thr Lys Ile 
305                 310                 315                 320 


Tyr Val Lys Asn Tyr Phe Arg Leu Thr Ile Leu Ser Glu Ala Ser His 
                325                 330                 335     


Trp Leu Gln Gln Asp Gln Pro Asp Ile Val Asn Lys Leu Ile Trp Thr 
            340                 345                 350         


Phe Leu Lys Glu Glu Thr Arg Lys Lys Asp 
        355                 360         


<210>  13
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  13
caatggttcc tgtcgtccag tag                                               23


<210>  14
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  14
agttctccac ctggaccaag tc                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  15
atctggtggc ataaacggcg tg                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  16
ccctcaagca gtgttcattg gc                                                22


<210>  17
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  17
ggaaatggct ctgaaactct cgc                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  18
gcactatgtc tctgctggtc atg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  19
gccatctcta cctccataaa cgc                                               23


<210>  20
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  20
tctcagcctg gagcactaag tg                                                22


<210>  21
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  21
accactcatg gatgaaagct aca                                               23


<210>  22
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  22
tcaggtagat tggctccaca g                                                 21


<210>  23
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  23
gttttccacc tggaccaata cgg                                               23


<210>  24
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  24
tggtgcctgt tgtccagtag ag                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  25
agcctcttca gagcaagcga tg                                                22


<210>  26
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  26
ggatttcctc ctcagtgacc atc                                               23


<210>  27
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  27
tgttgtggct gtggacttgc ga                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  28
gccacaagga tgcacttcga gt                                                22


<210>  29
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  29
ctgctggaga aagaggcaaa cc                                                22


<210>  30
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  30
ccataacctc tcaaatccag tgc                                               23


