                         SEQUENCE LISTING

<110>  MINERVA BIOTECHNOLOGIES CORPORATION
 
<120>  ANTI-VARIABLE MUC1* ANTIBODIES AND USES THEREOF

<130>  16831-169WO0

<140>  PCT/US2021/071017
<141>  2021-07-27

<160>  1879  

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Ala Ser Ala Asn Leu  
    1250                 1255 


<210>  2
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR sequence

<400>  2

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  3
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-10 peptide

<400>  3

Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
1               5                   10                  15      


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
            20                  25                  30          


Ser Gly Ala 
        35  


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-19 peptide

<400>  4

Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
1               5                   10                  15      


Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
            20                  25      


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-23 peptide

<400>  5

Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe 
1               5                   10                  15      


Ser Ala Gln Ser Gly Ala 
            20          


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-26 peptide

<400>  6

Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
1               5                   10                  15      


Ser Gly Ala 
            


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-30 peptide

<400>  7

Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
1               5                   10                  15  


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-10/C-5 peptide

<400>  8

Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
1               5                   10                  15      


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser 
            20                  25                  30  


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-19/C-5 peptide

<400>  9

Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val 
1               5                   10                  15      


Pro Phe Pro Phe Ser 
            20      


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-36 peptide

<400>  10

Phe Pro Phe Ser Ala Gln Ser Gly Ala 
1               5                   


<210>  11

<400>  11
000

<210>  12
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Heavy chain variable region sequence

<400>  12
gaggtgaagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgtag tctctggatt cactttcagt agatatggca tgtcttgggt tcgccagact      120

ccaggcaaga ggctggagtg ggtcgcaacc attagtggtg gcggtactta catctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt atcactgtac aagggataac      300

tacggtagga actacgacta cggtatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Heavy chain variable region sequence

<400>  13

Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr His Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 1 (FWR1) sequence

<400>  14
gaggtgaagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgtag tctct                                                        75


<210>  15
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 1 (FWR1) sequence

<400>  15

Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  16
ggattcactt tcagtagata tggcatgtct                                        30


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  17

Arg Tyr Gly Met Ser 
1               5   


<210>  18
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 2 (FWR2) sequence

<400>  18
tgggttcgcc agactccagg caagaggctg gagtgggtcg ca                          42


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 2 (FWR2) sequence

<400>  19

Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  20
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  20
accattagtg gtggcggtac ttacatctac tatccagaca gtgtgaaggg g                51


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  21

Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  22
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aagtctgagg acacagccat gtatcactgt acaagg                                 96


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  23

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr His Cys Thr Arg 
            20                  25                  30          


<210>  24
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       3 (CDR3) sequence:

<400>  24
gataactacg gtaggaacta cgactacggt atggactac                              39


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 heavy chain variable complementarity determining regions
       3 (CDR3) sequence:

<400>  25

Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable region sequence from 
       IGHV3-21*03

<400>  38
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagc                                                                 366


<210>  39
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable region sequence from 
       IGHV3-21*03

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  40
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  42
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  42
aggtatggca tgagc                                                        15


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  43

Arg Tyr Gly Met Ser 
1               5   


<210>  44
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  44
tgggtccgcc aggctccagg gaagaggctg gagtgggtct ca                          42


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  45

Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ser 
1               5                   10                  


<210>  46
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  46
accattagtg gcggaggcac ctacatatac tacccagact cagtgaaggg c                51


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  47

Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  48
cgattcacca tctccagaga caacgccaag aacaccctgt atctgcaaat gaacagcctg       60

agagccgagg acacggctgt gtattactgt accaga                                 96


<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  49

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  50
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  50
gataactatg gccgcaacta tgattatggc atggattat                              39


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  51

Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  52
<211>  1442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG2 heavy chain synthesized by Genescript

<400>  52
gaattctaag cttgggccac catggaactg gggctccgct gggttttcct tgttgctatt       60

ttagaaggtg tccagtgtga ggtgcagctg gtggagtctg ggggaggcct ggtcaagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag gtatggcatg      180

agctgggtcc gccaggctcc agggaagagg ctggagtggg tctcaaccat tagtggcgga      240

ggcacctaca tatactaccc agactcagtg aagggccgat tcaccatctc cagagacaac      300

gccaagaaca ccctgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtgtat      360

tactgtacca gagataacta tggccgcaac tatgattatg gcatggatta ttggggccag      420

ggcaccctgg tgaccgtgag cagcgcctcc accaagggcc catcggtctt ccccctggcg      480

ccctgctcca ggagcacctc cgagagcaca gccgccctgg gctgcctggt caaggactac      540

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc      600

ttcccagctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      660

tccagcaact tcggcaccca gacctacacc tgcaacgtag atcacaagcc cagcaacacc      720

aaggtggaca agacagttga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      780

cctgtggcag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      840

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccacgaaga ccccgaggtc      900

cagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccacgggag      960

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgttgtgca ccaggactgg     1020

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccagc ccccatcgag     1080

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1140

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1200

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1260

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1320

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1380

aaccactaca cgcagaagag cctctccctg tctccgggta aatagtaagt ttaaactcta     1440

ga                                                                    1442


<210>  53
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG2 heavy chain synthesized by Genescript


<220>
<221>  misc_feature
<222>  (477)..(477)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Glu Phe Ala Trp Ala Thr Met Glu Leu Gly Leu Arg Trp Val Phe Leu 
1               5                   10                  15      


Val Ala Ile Leu Glu Gly Val Gln Cys Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly 
65                  70                  75                  80  


Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg 
        115                 120                 125             


Asn Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Thr Leu Xaa 
465                 470                 475         


<210>  54
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG2 heavy chain constant region sequence

<400>  54
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaata g                                                981


<210>  55
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 heavy chain constant region sequence

<400>  55

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  56
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG1 heavy chain sequence

<400>  56
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa cccactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtcc cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgacagtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                        1362


<210>  57
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 IgG1 heavy chain sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Pro Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  58
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region sequence

<400>  58
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgaca gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tgataa                                996


<210>  59
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region sequence

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Light Chain variable region sequence

<400>  65
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga ggaggtcacc       60

ctaacctgca gtgccacctc aagtgtaagt tacatacact ggttccagca gaggccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtggatatgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttccc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaa                                                    318


<210>  66
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 Light Chain variable region sequence

<400>  66

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Tyr Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  67
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 1 (FWR1) sequence

<400>  67
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga ggaggtcacc       60

ctaacctgc                                                               69


<210>  68
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 1 (FWR1) sequence

<400>  68

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Leu Thr Cys 
            20              


<210>  69
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  69
agtgccacct caagtgtaag ttacatacac                                        30


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  70

Ser Ala Thr Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  71
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 2 (FWR2) sequence

<400>  71
tggttccagc agaggccagg cacttctccc aaactctgga tttat                       45


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 2 (FWR2) sequence

<400>  72

Trp Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  73
agcacatcca acctggcttc t                                                 21


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  74

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  75
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 3 (FWR3) sequence

<400>  75
ggagtccctg ttcgcttcag tggcagtgga tatgggacct cttactctct cacaatcagc       60

cgaatggagg ctgaagatgc tgccacttat tactgc                                 96


<210>  76
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable framework region 3 (FWR3) sequence

<400>  76

Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr Gly Thr Ser Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  77
cagcaaagga gtagttcccc attcacg                                           27


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse E6 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  78

Gln Gln Arg Ser Ser Ser Pro Phe Thr 
1               5                   


<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82

<400>  82
000

<210>  83

<400>  83
000

<210>  84

<400>  84
000

<210>  85

<400>  85
000

<210>  86

<400>  86
000

<210>  87

<400>  87
000

<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
000

<210>  91

<400>  91
000

<210>  92

<400>  92
000

<210>  93
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable region sequence from 
       IGKV3-11*02

<400>  93
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgca gcgccaccag cagtgttagc tacatccact ggtaccaaca gaggcctggc      120

cagagcccca ggctcctcat ctatagcacc tccaacctgg ccagcggcat cccagccagg      180

ttcagtggca gtgggtctgg gagcgactac actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagcgt agcagctccc ctttcacctt tggcagcggc      300

accaaagtgg aaattaaa                                                    318


<210>  94
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable region sequence from 
       IGKV3-11*02

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  95
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  95
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgc                                                               69


<210>  96
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  96

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys 
            20              


<210>  97
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  97
agcgccacca gcagtgttag ctacatccac                                        30


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  98

Ser Ala Thr Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  99
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  99
tggtaccaac agaggcctgg ccagagcccc aggctcctca tctat                       45


<210>  100
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  100

Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  101
agcacctcca acctggccag c                                                 21


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  102

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  103
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  103
ggcatcccag ccaggttcag tggcagtggg tctgggagcg actacactct caccatcagc       60

agcctagagc ctgaagattt tgcagtttat tactgt                                 96


<210>  104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  104

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  105
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  105
cagcagcgta gcagctcccc tttcacc                                           27


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  106

Gln Gln Arg Ser Ser Ser Pro Phe Thr 
1               5                   


<210>  107
<211>  740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 Kappa light chain synthesized by Genescript

<400>  107
gaattctaag cttgggccac catggaagcc ccagcgcagc ttctcttcct cctgctactc       60

tggctcccag ataccactgg agaaattgtg ttgacacagt ctccagccac cctgtctttg      120

tctccagggg aaagagccac cctcacctgc agcgccacca gcagtgttag ctacatccac      180

tggtaccaac agaggcctgg ccagagcccc aggctcctca tctatagcac ctccaacctg      240

gccagcggca tcccagccag gttcagtggc agtgggtctg ggagcgacta cactctcacc      300

atcagcagcc tagagcctga agattttgca gtttattact gtcagcagcg tagcagctcc      360

cctttcacct ttggcagcgg caccaaagtg gaaattaaaa ggacggtggc tgcaccatct      420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      720

tagtaagttt aaactctaga                                                  740


<210>  108
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 Kappa light chain synthesized by Genescript


<220>
<221>  misc_feature
<222>  (243)..(243)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Glu Phe Ala Trp Ala Thr Met Glu Ala Pro Ala Gln Leu Leu Phe Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Ile Val Leu Thr Gln 
            20                  25                  30          


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr 
        35                  40                  45              


Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Val 
225                 230                 235                 240 


Thr Leu Xaa 
            


<210>  109
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Kappa light chain constant region sequence

<400>  109
aggacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Kappa light chain constant region sequence

<400>  110

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  111
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 lambda light chain sequence

<400>  111
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgca gcgccaccag cagtgttagc tacatccact ggtaccaaca gaggcctggc      120

cagagcccca ggctcctcat ctatagcacc tccaacctgg ccagcggcat cccagccagg      180

ttcagtggca gtgggtctgg gagcgactac actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagcgt agcagctccc ctttcacctt tggcagcggc      300

accaaagtgg aaattaaagg tcagcccaag gctgccccct cggtcactct gttcccgccc      360

tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac      420

ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag      480

accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg      540

acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc      600

accgtggaga agacagtggc ccctacagaa tgttcatagt aa                         642


<210>  112
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 lambda light chain sequence

<400>  112

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  113
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized lambda light chain constant region sequence

<400>  113
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttcata gtaa                                             324


<210>  114
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized lambda light chain constant region sequence

<400>  114

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable region sequence

<400>  118
gaggtccagc tggaggagtc agggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt ggctatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtactta tatctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgc aagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tccgccaaaa cgacaccccc atctgtctat                                       390


<210>  119
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable region sequence

<400>  119

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr 
    130 


<210>  120
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 1 (FWR1) sequence

<400>  120
gaggtccagc tggaggagtc agggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  121
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 1 (FWR1) sequence

<400>  121

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  122
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  122
ggctatgcca tgtct                                                        15


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  123

Gly Tyr Ala Met Ser 
1               5   


<210>  124
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 2 (FWR2) sequence

<400>  124
tgggttcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 2 (FWR2) sequence

<400>  125

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  126
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  126
accattagta gtggtggtac ttatatctac tatccagaca gtgtgaaggg g                51


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  127

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 3 (FWR3) sequence

<400>  128
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aggtctgagg acacggccat gtattactgt gcaaga                                 96


<210>  129
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable framework region 3 (FWR3) sequence

<400>  129

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  130
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  130
cttggggggg ataattacta cgaatacttc gatgtc                                 36


<210>  131
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  131

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val 
1               5                   10          


<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized derived from IGHV3-21*04 - Humanized C2 heavy chain 
       variable region sequence

<400>  144
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tcc                                                                    363


<210>  145
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable region sequence

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  146
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  146
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  147
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  148
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  148
ggctatgcca tgagc                                                        15


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  149

Gly Tyr Ala Met Ser 
1               5   


<210>  150
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  150
tgggtccgcc aggctccagg gaaggggctg gagtgggtct caa                         43


<210>  151
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  151

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  152
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  152
accattagta gtggcggaac ctacatatac taccccgact cagtgaaggg c                51


<210>  153
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  153

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  154
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  154
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggccgt gtattactgt gcgaga                                 96


<210>  155
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  155

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  156
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  156
cttggggggg ataattacta cgaatacttc gatgtc                                 36


<210>  157
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  157

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val 
1               5                   10          


<210>  158
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG1 heavy chain sequence

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG2 heavy chain sequence

<400>  163
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccgcctcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc      420

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccagctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag      600

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag      660

cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc      900

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa atagtaa                                         1347


<210>  164
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 IgG2 heavy chain sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable region sequence

<400>  168
gacattgtga tcacacagtc tacagcttcc ttaggtgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagagac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgttc      300

acgttcggag gggggaccaa gctggagata aaacgggctg atgctgcacc aactgtatcc      360


<210>  169
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable region sequence

<400>  169

Asp Ile Val Ile Thr Gln Ser Thr Ala Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120 


<210>  170
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 1 (FWR1) sequence

<400>  170
gacattgtga tcacacagtc tacagcttcc ttaggtgtat ctctggggca gagggccacc       60

atctcatgc                                                               69


<210>  171
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 1 (FWR1) sequence

<400>  171

Asp Ile Val Ile Thr Gln Ser Thr Ala Ser Leu Gly Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  172
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  172
agggccagca aaagtgtcag tacatctggc tatagttata tgcac                       45


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  173

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  174
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 2 (FWR2) sequence

<400>  174
tggtaccaac agagaccagg acagccaccc aaactcctca tctat                       45


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 2 (FWR2) sequence

<400>  175

Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  176
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  176
cttgcatcca acctagaatc                                                   20


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  177

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  178
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 3 (FWR3) sequence

<400>  178
tggggtccct gccaggttca gtggcagtgg gtctgggaca gacttcaccc tcaacatcca       60

tcctgtggag gaggaggatg ctgcaaccta ttactgt                                97


<210>  179
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable framework region 3 (FWR3) sequence

<400>  179

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  180
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  180
cagcacagta gggagcttcc gttcacg                                           27


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C2 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  181

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized derived from IGKV73*01 - Humanized C2 light chain 
       variable region sequence

<400>  194
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgca gagccagtaa gagtgtcagt accagcggat actcctacat gcactggtat      120

cagcagaaac caggacaacc tcctaaactc ctgatttacc tggcatccaa tctggagagc      180

ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat      240

cctgtggaag ctaatgatac tgcaaattat tactgtcagc acagtaggga gctgcctttc      300

acattcggcg gagggaccaa ggtggagatc aaacgaact                             339


<210>  195
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized derived from IGKV73*01 - Humanized C2 light chain 
       variable region sequence

<400>  195

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr 
    


<210>  196
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  196
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgc                                                               69


<210>  197
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  197

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys 
            20              


<210>  198
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  198
agagccagta agagtgtcag taccagcgga tactcctaca tgcac                       45


<210>  199
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  199

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  200
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  200
tggtatcagc agaaaccagg acaacctcct aaactcctga tttac                       45


<210>  201
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 heavy light variable framework region 2 (FWR2) acid 
       sequence

<400>  201

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  202
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  202
ctggcatcca atctggagag c                                                 21


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  203

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  204
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  204
ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat       60

cctgtggaag ctaatgatac tgcaaattat tactgt                                 96


<210>  205
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  205

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys 
            20                  25                  30          


<210>  206
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  206
cagcacagta gggagctgcc tttcaca                                           27


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  207

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  208
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  208
ctgcagagta agaattttcc tcccaca                                           27


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  209

Leu Gln Ser Lys Asn Phe Pro Pro Thr 
1               5                   


<210>  210

<400>  210
000

<210>  211

<400>  211
000

<210>  212

<400>  212
000

<210>  213

<400>  213
000

<210>  214

<400>  214
000

<210>  215

<400>  215
000

<210>  216

<400>  216
000

<210>  217

<400>  217
000

<210>  218

<400>  218
000

<210>  219

<400>  219
000

<210>  220

<400>  220
000

<210>  221

<400>  221
000

<210>  222
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine Ig kappa chain leader sequence

<400>  222
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gac                                                                     63


<210>  223
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine Ig kappa chain leader sequence

<400>  223

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  224
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Interleukin2 (IL2) leader sequence

<400>  224
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210>  225
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Interleukin2 (IL2) leader sequence

<400>  225

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  226
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD33 leader sequence

<400>  226
atgcctcttc tgcttctgct tcctctgctt tgggctggag ctcttgct                    48


<210>  227
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 leader sequence

<400>  227

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  228
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV321*03 leader sequence

<400>  228
atggaactgg ggctccgctg ggttttcctt gttgctattt tagaaggtgt ccagtgt          57


<210>  229
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV321*03 leader sequence

<400>  229

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  230
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGHV311*02 leader sequence

<400>  230
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccactgga       60


<210>  231
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGHV311*02 leader sequence

<400>  231

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  232
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain GS3

<400>  232
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgaaattgtg      420

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctcacctgc      480

agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc      540

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      600

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      720

gaaattaaa                                                              729


<210>  233
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain GS3

<400>  233

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  234
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain IgG1noC

<400>  234
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcgata aaacccatac taaaccgcca aaaccggcgc cggaactgct gggtggtcct      420

ggtaccggtg aaattgtgtt gacacagtct ccagccaccc tgtctttgtc tccaggggaa      480

agagccaccc tcacctgcag cgccaccagc agtgttagct acatccactg gtaccaacag      540

aggcctggcc agagccccag gctcctcatc tatagcacct ccaacctggc cagcggcatc      600

ccagccaggt tcagtggcag tgggtctggg agcgactaca ctctcaccat cagcagccta      660

gagcctgaag attttgcagt ttattactgt cagcagcgta gcagctcccc tttcaccttt      720

ggcagcggca ccaaagtgga aattaaa                                          747


<210>  235
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain IgG1noC

<400>  235

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Lys 
        115                 120                 125             


Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Glu 
    130                 135                 140                 


Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
145                 150                 155                 160 


Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser 
            180                 185                 190         


Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  236
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region

<400>  236
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcgata aaacccatac taaaccgcca aaaccggcgc cggaactgct gggtggtcct      420

ggtaccggta ctggtggtcc gactattaaa cctccgaaac ctccgaaacc tgctccgaac      480

ctgctgggtg gtccggaaat tgtgttgaca cagtctccag ccaccctgtc tttgtctcca      540

ggggaaagag ccaccctcac ctgcagcgcc accagcagtg ttagctacat ccactggtac      600

caacagaggc ctggccagag ccccaggctc ctcatctata gcacctccaa cctggccagc      660

ggcatcccag ccaggttcag tggcagtggg tctgggagcg actacactct caccatcagc      720

agcctagagc ctgaagattt tgcagtttat tactgtcagc agcgtagcag ctcccctttc      780

acctttggca gcggcaccaa agtggaaatt aaa                                   813


<210>  237
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Lys 
        115                 120                 125             


Pro Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr 
    130                 135                 140                 


Gly Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn 
145                 150                 155                 160 


Leu Leu Gly Gly Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                165                 170                 175     


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser 
            180                 185                 190         


Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro 
        195                 200                 205             


Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
                245                 250                 255     


Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            260                 265                 270     


<210>  238
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain GS3

<400>  238
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  239
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain GS3

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  240

<400>  240
000

<210>  241

<400>  241
000

<210>  242
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region

<400>  242
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccgataaaa cccatactaa accgccaaaa ccggcgccgg aactgctggg tggtcctggt      420

accggtactg gtggtccgac tattaaacct ccgaaacctc cgaaacctgc tccgaacctg      480

ctgggtggtc cggacattgt gctgacccag tctccagcct ccttggccgt gtctccagga      540

cagagggcca ccatcacctg cagagccagt aagagtgtca gtaccagcgg atactcctac      600

atgcactggt atcagcagaa accaggacaa cctcctaaac tcctgattta cctggcatcc      660

aatctggaga gcggggtccc agccaggttc agcggcagtg ggtctgggac cgatttcacc      720

ctcacaatta atcctgtgga agctaatgat actgcaaatt attactgtca gcacagtagg      780

gagctgcctt tcacattcgg cggagggacc aaggtggaga tcaaacgaac t               831


<210>  243
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C2 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region

<400>  243

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro 
        115                 120                 125             


Pro Lys Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly 
    130                 135                 140                 


Gly Pro Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
                165                 170                 175     


Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser 
            180                 185                 190         


Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
    210                 215                 220                 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys 
                245                 250                 255     


Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val 
            260                 265                 270         


Glu Ile Lys Arg Thr 
        275         


<210>  244
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain GS3

<400>  244
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcggc      360

ggtggcggat ccggcggtgg cggatccggc ggtggcggat ccgatattgt gatgacccag      420

actccactct ctctgtccgt cacccctgga cagccggcct ccatctcctg caggtctagt      480

cagaccattg tccatagtaa tggaaacacc tatttggagt ggtacctgca gaagccaggc      540

cagtctccac agctcctgat ctataaggtt tccaaccggt tctctggagt gccagatagg      600

ttcagtggca gcgggtcagg gacagatttc acactgaaaa tcagccgggt ggaggctgag      660

gatgttgggg tttattactg cttccaaggt agccacgtgc ctttcacctt cggcggaggg      720

accaaggtgg agatcaaacg aact                                             744


<210>  245
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain GS3

<400>  245

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
            180                 185                 190         


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr 
                245             


<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region

<400>  248
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgat      360

aaaacccata ctaaaccgcc aaaaccggcg ccggaactgc tgggtggtcc tggtaccggt      420

actggtggtc cgactattaa acctccgaaa cctccgaaac ctgctccgaa cctgctgggt      480

ggtccggata ttgtgatgac ccagactcca ctctctctgt ccgtcacccc tggacagccg      540

gcctccatct cctgcaggtc tagtcagacc attgtccata gtaatggaaa cacctatttg      600

gagtggtacc tgcagaagcc aggccagtct ccacagctcc tgatctataa ggtttccaac      660

cggttctctg gagtgccaga taggttcagt ggcagcgggt cagggacaga tttcacactg      720

aaaatcagcc gggtggaggc tgaggatgtt ggggtttatt actgcttcca aggtagccac      780

gtgcctttca ccttcggcgg agggaccaag gtggagatca aacgaact                   828


<210>  249
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 single chain X4 (linker is IgG1 and IgG2 modified 
       hinge region

<400>  249

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Asp Lys Thr His Thr Lys Pro Pro Lys 
        115                 120                 125             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Gly Thr Gly Thr Gly Gly Pro 
    130                 135                 140                 


Thr Ile Lys Pro Pro Lys Pro Pro Lys Pro Ala Pro Asn Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr 
                165                 170                 175     


Pro Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val 
            180                 185                 190         


His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly 
        195                 200                 205             


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    210                 215                 220                 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe 
                245                 250                 255     


Gln Gly Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Arg Thr 
        275     


<210>  250
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain GS3 (linker is [Gly4Ser1]3

<400>  250
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccggcggt      360

ggcggatccg gcggtggcgg atccggcggt ggcggatccg acatcgtgat gacccagtct      420

ccagactccc tggctgtgtc tctgggcgag agggccacca tcaactgcag ggccagcaag      480

agtgttagca ccagcggcta cagctacatg cactggtacc agcagaaacc aggacagcct      540

cctaagctgc tcatttacct ggtgtctaac ctggaatccg gggtccctga ccgattcagt      600

ggcagcgggt ctgggacaga tttcactctc accatcagca gcctgcaggc tgaagatgtg      660

gcagtttatt actgtcaaca cattcgggaa ctgaccagga gtgaattcgg cggagggacc      720

aaggtggaga tcaaacgaac t                                                741


<210>  251
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 single chain GS3 (linker is [Gly4Ser1]3

<400>  251

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys 
145                 150                 155                 160 


Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln His Ile Arg Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr 
                245         


<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSECTag2 E6 scFVFC

<400>  256
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccga ggtgcagctg gtggagtctg ggggaggcct ggtcaagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag gtatggcatg      180

agctgggtcc gccaggctcc agggaagagg ctggagtggg tctcaaccat tagtggcgga      240

ggcacctaca tatactaccc agactcagtg aagggccgat tcaccatctc cagagacaac      300

gccaagaaca ccctgtatct gcaaatgaac agcctgagag ccgaggacac ggctgtgtat      360

tactgtacca gagataacta tggccgcaac tatgattatg gcatggatta ttggggccag      420

ggcaccctgg tgaccgtgag cagcggcggt ggcggatccg gcggtggcgg atccggcggt      480

ggcggatccg aaattgtgtt gacacagtct ccagccaccc tgtctttgtc tccaggggaa      540

agagccaccc tcacctgcag cgccaccagc agtgttagct acatccactg gtaccaacag      600

aggcctggcc agagccccag gctcctcatc tatagcacct ccaacctggc cagcggcatc      660

ccagccaggt tcagtggcag tgggtctggg agcgactaca ctctcaccat cagcagccta      720

gagcctgaag attttgcagt ttattactgt cagcagcgta gcagctcccc tttcaccttt      780

ggcagcggca ccaaagtgga aattaaagag cccaaatctt gtgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

aaatgataa                                                             1509


<210>  257
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSECTag2 E6 scFVFC

<400>  257

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly 
65                  70                  75                  80  


Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly 
        115                 120                 125             


Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
                165                 170                 175     


Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val 
            180                 185                 190         


Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser 
                245                 250                 255     


Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys 
            500     


<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc sequence

<400>  272
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatgat aa                         702


<210>  273
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc sequence

<400>  273

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  274
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2CH3 domain sequence

<400>  274
ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc       60

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      120

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      180

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      240

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      300

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      360

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc      420

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      480

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac      540

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      600

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa      660

tgataa                                                                 666


<210>  275
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2CH3 domain sequence

<400>  275

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  276
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH3 domain sequence

<400>  276
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag       60

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      120

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      180

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      240

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      300

ctctccctgt ctccgggtaa atgataa                                          327


<210>  277
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH3 domain sequence

<400>  277

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8/CD8/CD28/CD3z sequence - NCD8lshuMNE6scFvCD8ecd 
       fragment CD8 transmembrane CD28 CD3zetaC

<400>  297
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca gaagcaagcg gtctcggctc     1020

ctgcattctg attacatgaa catgacccca agaagaccag gccccaccag gaaacattac     1080

cagccctacg ctccgccacg cgacttcgct gcctaccggt cccgcgttaa gttctcccga     1140

tcagccgacg cgcctgctta caagcagggc cagaaccaac tgtacaacga gctgaatctc     1200

ggtagacggg aagagtacga cgtgttggac aaacggagag gccgcgaccc agaaatgggc     1260

ggcaagcctc gcaggaaaaa cccccaggag ggactgtaca atgagttgca gaaagataag     1320

atggcagaag cttatagcga gatcggaatg aagggggaaa ggagacgagg gaaaggacac     1380

gacggccttt atcagggcct gtccacagca acaaaagata cgtatgacgc cctccatatg     1440

caggcacttc caccacggtg ataa                                            1464


<210>  298
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8/CD8/CD28/CD3z sequence - NCD8lshuMNE6scFvCD8ecd 
       fragment CD8 transmembrane CD28 CD3zetaC

<400>  298

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  299

<400>  299
000

<210>  300
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8/CD8/41BB/CD3z sequence - NCD8lshuMNE6scFvCD8ecd 
       fragment CD8 transmembrane 41BB CD3zetaC

<400>  300
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca aaaggggccg caaaaaactc     1020

ctttacattt ttaagcagcc ttttatgagg ccagtacaga cgactcaaga ggaagacggg     1080

tgctcatgcc gctttcctga ggaggaggaa ggagggtgcg aactgcgcgt taagttctcc     1140

cgatcagccg acgcgcctgc ttacaagcag ggccagaacc aactgtacaa cgagctgaat     1200

ctcggtagac gggaagagta cgacgtgttg gacaaacgga gaggccgcga cccagaaatg     1260

ggcggcaagc ctcgcaggaa aaacccccag gagggactgt acaatgagtt gcagaaagat     1320

aagatggcag aagcttatag cgagatcgga atgaaggggg aaaggagacg agggaaagga     1380

cacgacggcc tttatcaggg cctgtccaca gcaacaaaag atacgtatga cgccctccat     1440

atgcaggcac ttccaccacg gtgataa                                         1467


<210>  301
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8/CD8/41BB/CD3z sequence - NCD8lshuMNE6scFvCD8ecd 
       fragment CD8 transmembrane 41BB CD3zetaC

<400>  301

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  302

<400>  302
000

<210>  303
<211>  1590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8/CD8/CD28/41BB/CD3z sequence - NCD8lshuMNE6scFvCD8ecd 
       fragment CD8 transmembrane CD28 41BB CD3zetaC

<400>  303
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

ccagaggtcc agctggttga gagtggcggt gggctggtta agcctggcgg ctccctgcgg      120

ctgagctgcg ccgcgagtgg atttactttc agccgatatg ggatgagttg ggtgcggcaa      180

gctcccggga agaggctgga atgggtctca acaatctccg gggggggcac ttacatctat      240

taccccgact cagtcaaggg gagatttacc atttcacgag acaacgctaa gaataccctg      300

tatttgcaga tgaattctct gagagcagag gacacagctg tttactattg tacccgcgac      360

aactatggca ggaactacga ctacggtatg gactattggg gacaagggac attggttaca      420

gtgagcagtg gcggcggggg cagcggagga ggaggcagcg gtgggggggg cagcgagata      480

gtgctcacgc agtcacccgc gactctcagt ctctcacctg gggaacgagc taccctgacg      540

tgctctgcta cctcctcagt gtcatatatt cactggtatc agcaacggcc cgggcagtcc      600

cctagattgc tcatttatag tacctctaat ctggcctcag gtatccctgc acgattttct      660

ggatctggtt caggttctga ttacaccctc actatctcta gcctggagcc tgaagacttt      720

gccgtttatt actgccagca gaggtctagc tccccattca cctttgggag tgggaccaag      780

gttgaaatta aaacgacaac cccggccccc agaccaccaa cgccagcccc caccatcgcc      840

agccaacccc tgtctctgag accagaagcc tgtaggcctg ccgccggtgg agctgtgcac      900

acaagaggac tggatttcgc ctgtgatatc tacatttggg ccccgctcgc aggcacatgt      960

ggagtgctcc tcctctccct ggtgattacc ctgtactgca gaagcaagcg gtctcggctc     1020

ctgcattctg attacatgaa catgacccca agaagaccag gccccaccag gaaacattac     1080

cagccctacg ctccgccacg cgacttcgct gcctaccggt ccaaaagggg ccgcaaaaaa     1140

ctcctttaca tttttaagca gccttttatg aggccagtac agacgactca agaggaagac     1200

gggtgctcat gccgctttcc tgaggaggag gaaggagggt gcgaactgcg cgttaagttc     1260

tcccgatcag ccgacgcgcc tgcttacaag cagggccaga accaactgta caacgagctg     1320

aatctcggta gacgggaaga gtacgacgtg ttggacaaac ggagaggccg cgacccagaa     1380

atgggcggca agcctcgcag gaaaaacccc caggagggac tgtacaatga gttgcagaaa     1440

gataagatgg cagaagctta tagcgagatc ggaatgaagg gggaaaggag acgagggaaa     1500

ggacacgacg gcctttatca gggcctgtcc acagcaacaa aagatacgta tgacgccctc     1560

catatgcagg cacttccacc acggtgataa                                      1590


<210>  304
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8/CD8/CD28/41BB/CD3z sequence - NCD8lshuMNE6scFvCD8ecd 
       fragment CD8 transmembrane CD28 41BB CD3zetaC

<400>  304

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    370                 375                 380                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
385                 390                 395                 400 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                405                 410                 415     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            420                 425                 430         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        435                 440                 445             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    450                 455                 460                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


<210>  305

<400>  305
000

<210>  306
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/CD28/41BB/CD3z sequence - NCD8lshuMNC2scFvCD8ecd 
       fragment CD8 transmembrane CD28 41BB CD3zetaC

<400>  306
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaga     1020

agcaagcggt ctcggctcct gcattctgat tacatgaaca tgaccccaag aagaccaggc     1080

cccaccagga aacattacca gccctacgct ccgccacgcg acttcgctgc ctaccggtcc     1140

aaaaggggcc gcaaaaaact cctttacatt tttaagcagc cttttatgag gccagtacag     1200

acgactcaag aggaagacgg gtgctcatgc cgctttcctg aggaggagga aggagggtgc     1260

gaactgcgcg ttaagttctc ccgatcagcc gacgcgcctg cttacaagca gggccagaac     1320

caactgtaca acgagctgaa tctcggtaga cgggaagagt acgacgtgtt ggacaaacgg     1380

agaggccgcg acccagaaat gggcggcaag cctcgcagga aaaaccccca ggagggactg     1440

tacaatgagt tgcagaaaga taagatggca gaagcttata gcgagatcgg aatgaagggg     1500

gaaaggagac gagggaaagg acacgacggc ctttatcagg gcctgtccac agcaacaaaa     1560

gatacgtatg acgccctcca tatgcaggca cttccaccac ggtgataa                  1608


<210>  307
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/CD28/41BB/CD3z sequence - NCD8lshuMNC2scFvCD8ecd 
       fragment CD8 transmembrane CD28 41BB CD3zetaC

<400>  307

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr Pro Ala Pro Arg 
                245                 250                 255     


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
            260                 265                 270         


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
        275                 280                 285             


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
    290                 295                 300                 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  308

<400>  308
000

<210>  309

<400>  309
000

<210>  310

<400>  310
000

<210>  311

<400>  311
000

<210>  312

<400>  312
000

<210>  313

<400>  313
000

<210>  314

<400>  314
000

<210>  315

<400>  315
000

<210>  316

<400>  316
000

<210>  317

<400>  317
000

<210>  318

<400>  318
000

<210>  319

<400>  319
000

<210>  320

<400>  320
000

<210>  321

<400>  321
000

<210>  322

<400>  322
000

<210>  323

<400>  323
000

<210>  324

<400>  324
000

<210>  325

<400>  325
000

<210>  326

<400>  326
000

<210>  327

<400>  327
000

<210>  328

<400>  328
000

<210>  329

<400>  329
000

<210>  330

<400>  330
000

<210>  331

<400>  331
000

<210>  332

<400>  332
000

<210>  333

<400>  333
000

<210>  334

<400>  334
000

<210>  335

<400>  335
000

<210>  336

<400>  336
000

<210>  337

<400>  337
000

<210>  338

<400>  338
000

<210>  339

<400>  339
000

<210>  340

<400>  340
000

<210>  341
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized E6 scFV sequence in CAR

<400>  341
gaggtccagc tggttgagag tggcggtggg ctggttaagc ctggcggctc cctgcggctg       60

agctgcgccg cgagtggatt tactttcagc cgatatggga tgagttgggt gcggcaagct      120

cccgggaaga ggctggaatg ggtctcaaca atctccgggg ggggcactta catctattac      180

cccgactcag tcaaggggag atttaccatt tcacgagaca acgctaagaa taccctgtat      240

ttgcagatga attctctgag agcagaggac acagctgttt actattgtac ccgcgacaac      300

tatggcagga actacgacta cggtatggac tattggggac aagggacatt ggttacagtg      360

agcagtggcg gcgggggcag cggaggagga ggcagcggtg gggggggcag cgagatagtg      420

ctcacgcagt cacccgcgac tctcagtctc tcacctgggg aacgagctac cctgacgtgc      480

tctgctacct cctcagtgtc atatattcac tggtatcagc aacggcccgg gcagtcccct      540

agattgctca tttatagtac ctctaatctg gcctcaggta tccctgcacg attttctgga      600

tctggttcag gttctgatta caccctcact atctctagcc tggagcctga agactttgcc      660

gtttattact gccagcagag gtctagctcc ccattcacct ttgggagtgg gaccaaggtt      720

gaaattaaa                                                              729


<210>  342
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized E6 scFV sequence in CAR

<400>  342

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  343
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  343
atggccctgc ccgtgaccgc tttgctgctc cccctggcgc tgctgctgca cgccgccagg       60

cca                                                                     63


<210>  344
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  344

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  345
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain sequence

<400>  345
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgat                                                       135


<210>  346
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain sequence

<400>  346

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  347
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD4 hinge domain sequence

<400>  347
tcgggacagg tcctgctgga atccaacatc aaggttctgc ccacatggtc caccccggtg       60

cagcca                                                                  66


<210>  348
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 hinge domain sequence

<400>  348

Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro 
            20          


<210>  349
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain sequence

<400>  349
aaacaccttt gtccaagtcc cctatttccc ggaccttcta agccc                       45


<210>  350
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain sequence

<400>  350

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15  


<210>  351

<400>  351
000

<210>  352

<400>  352
000

<210>  353

<400>  353
000

<210>  354

<400>  354
000

<210>  355

<400>  355
000

<210>  356

<400>  356
000

<210>  357

<400>  357
000

<210>  358

<400>  358
000

<210>  359

<400>  359
000

<210>  360

<400>  360
000

<210>  361
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrane domain sequence

<400>  361
ctctgctacc tgctggatgg aatcctcttc atctatggtg tcattctcac tgccttgttc       60

ctg                                                                     63


<210>  362
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrane domain sequence

<400>  362

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  363
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain sequence

<400>  363
atctacattt gggccccgct cgcaggcaca tgtggagtgc tcctcctctc cctggtgatt       60

accctgtact gc                                                           72


<210>  364
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain sequence

<400>  364

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  365
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD4 transmembrane domain sequence

<400>  365
atggccctga ttgtgctggg gggcgtcgcc ggcctcctgc ttttcattgg gctaggcatc       60

ttcttc                                                                  66


<210>  366
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 transmembrane domain sequence

<400>  366

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  367
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain sequence

<400>  367
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  368
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain sequence

<400>  368

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  369
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB transmembrane domain sequence

<400>  369
atcatctcct tctttcttgc gctgacgtcg actgcgttgc tcttcctgct gttcttcctc       60

acgctccgtt tctctgttgt t                                                 81


<210>  370
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB transmembrane domain sequence

<400>  370

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  371
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OX40 transmembrane domain sequence

<400>  371
gttgccgcca tcctgggcct gggcctggtg ctggggctgc tgggccccct ggccatcctg       60

ctggccctgt acctgctc                                                     78


<210>  372
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 transmembrane domain sequence

<400>  372

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  373
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain sequence

<400>  373
cgcgttaagt tctcccgatc agccgacgcg cctgcttaca agcagggcca gaaccaactg       60

tacaacgagc tgaatctcgg tagacgggaa gagtacgacg tgttggacaa acggagaggc      120

cgcgacccag aaatgggcgg caagcctcgc aggaaaaacc cccaggaggg actgtacaat      180

gagttgcaga aagataagat ggcagaagct tatagcgaga tcggaatgaa gggggaaagg      240

agacgaggga aaggacacga cggcctttat cagggcctgt ccacagcaac aaaagatacg      300

tatgacgccc tccatatgca ggcacttcca ccacgg                                336


<210>  374
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain sequence

<400>  374

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  375
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain variant sequence

<400>  375
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  376
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain variant sequence

<400>  376

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  377
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 domain sequence

<400>  377
agaagcaagc ggtctcggct cctgcattct gattacatga acatgacccc aagaagacca       60

ggccccacca ggaaacatta ccagccctac gctccgccac gcgacttcgc tgcctaccgg      120

tcc                                                                    123


<210>  378
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 domain sequence

<400>  378

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  379
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB domain sequence

<400>  379
aaaaggggcc gcaaaaaact cctttacatt tttaagcagc cttttatgag gccagtacag       60

acgactcaag aggaagacgg gtgctcatgc cgctttcctg aggaggagga aggagggtgc      120

gaactg                                                                 126


<210>  380
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB domain sequence

<400>  380

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  381

<400>  381
000

<210>  382

<400>  382
000

<210>  383

<400>  383
000

<210>  384

<400>  384
000

<210>  385

<400>  385
000

<210>  386

<400>  386
000

<210>  387

<400>  387
000

<210>  388

<400>  388
000

<210>  389

<400>  389
000

<210>  390

<400>  390
000

<210>  391
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VHVL) sequence

<400>  391
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgaaattgtg      420

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctcacctgc      480

agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc      540

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      600

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      720

gaaattaaa                                                              729


<210>  392
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VHVL) sequence

<400>  392

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  393
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VLVH) sequence

<400>  393
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctcacctgca gcgccaccag cagtgttagc tacatccact ggtaccaaca gaggcctggc      120

cagagcccca ggctcctcat ctatagcacc tccaacctgg ccagcggcat cccagccagg      180

ttcagtggca gtgggtctgg gagcgactac actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagcgt agcagctccc ctttcacctt tggcagcggc      300

accaaagtgg aaattaaagg cggtggcgga tccggcggtg gcggatccgg cggtggcgga      360

tccgaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      420

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      480

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      540

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      600

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      660

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      720

gtgagcagc                                                              729


<210>  394
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VLVH) sequence

<400>  394

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    130                 135                 140                 


Ala Ser Gly Phe Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Gly Lys Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly 
                165                 170                 175     


Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg 
    210                 215                 220                 


Asn Tyr Asp Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  395
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeC2 scFV (VHVL) sequence

<400>  395
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  396
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeC2 scFV (VHVL) sequence

<400>  396

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  397
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VLVH) sequence

<400>  397
gacattgtgc tgacccagtc tccagcctcc ttggccgtgt ctccaggaca gagggccacc       60

atcacctgca gagccagtaa gagtgtcagt accagcggat actcctacat gcactggtat      120

cagcagaaac caggacaacc tcctaaactc ctgatttacc tggcatccaa tctggagagc      180

ggggtcccag ccaggttcag cggcagtggg tctgggaccg atttcaccct cacaattaat      240

cctgtggaag ctaatgatac tgcaaattat tactgtcagc acagtaggga gctgcctttc      300

acattcggcg gagggaccaa ggtggagatc aaacgaactg gcggtggcgg atccggcggt      360

ggcggatccg gcggtggcgg atccgaggtg cagctggtgg agtctggggg aggcctggtc      420

aagcctgggg ggtccctgag actctcctgt gcagcctctg gattcacctt cagtggctat      480

gccatgagct gggtccgcca ggctccaggg aaggggctgg agtgggtctc aaccattagt      540

agtggcggaa cctacatata ctaccccgac tcagtgaagg gccgattcac catctccaga      600

gacaacgcca agaactcact gtatctgcaa atgaacagcc tgagagccga ggacacggcc      660

gtgtattact gtgcgagact tgggggggat aattactacg aatacttcga tgtctggggc      720

aaagggacca cggtcaccgt ctcctcc                                          747


<210>  398
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HumanizeE6 scFV (VLVH) sequence

<400>  398

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
145                 150                 155                 160 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                165                 170                 175     


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
225                 230                 235                 240 


Lys Gly Thr Thr Val Thr Val Ser Ser 
                245                 


<210>  399
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G4S1 linker sequence

<400>  399
ggcggtggcg gatcc                                                        15


<210>  400
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S1 linker sequence

<400>  400

Gly Gly Gly Gly Ser 
1               5   


<210>  401
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  [G4S1]x3 linker sequence

<400>  401
ggcggtggcg gatccggcgg tggcggatcc ggcggtggcg gatcc                       45


<210>  402
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [G4S1]x3 linker sequence

<400>  402

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  403
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8 aa GS linker sequence

<400>  403
ggcggttccg gcggtggatc cgga                                              24


<210>  404
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8 aa GS linker sequence

<400>  404

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  405
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12 aa GS linker sequence

<400>  405
ggcggttccg gcggtggatc cggcggtggc ggatccgga                              39


<210>  406
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12 aa GS linker sequence

<400>  406

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  407
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13 aa GS linker sequence

<400>  407
ggcggtggat ccggcggtgg cggatccggc ggtggatcc                              39


<210>  408
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13 aa GS linker sequence

<400>  408

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  409
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22 aa GS linker sequence

<400>  409
ggcggtggaa gcggcggtgg cggatccggc agcggcggaa gcggcggtgg cggatccggc       60

ggtgga                                                                  66


<210>  410
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22 aa GS linker sequence

<400>  410

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly 
            20          


<210>  411
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  24 aa GS linker sequence

<400>  411
ggcggttccg gcggtggatc cggcggtggc ggatccggag gcggttccgg cggtggatcc       60

ggcggtggcg gatccgga                                                     78


<210>  412
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24 aa GS linker sequence

<400>  412

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  


<210>  413
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Heavy chain variable region sequence

<400>  413
caggtccagc tgcagcagtc tgggcctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cagattcact gattatgcta tgaactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggagtt attagtactt tctctggtaa tacaaacttc      180

aaccagaagt ttaagggcaa ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatgt attactgtgc aagatcggat      300

tactacggcc catactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  414
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Heavy chain variable region sequence

<400>  414

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  415
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 1 (FWR1) sequence

<400>  415
caggtccagc tgcagcagtc tgggcctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cagattcact                                        90


<210>  416
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 1 (FWR1) sequence

<400>  416

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr 
            20                  25                  30  


<210>  417
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  417
gattatgcta tgaac                                                        15


<210>  418
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  418

Asp Tyr Ala Met Asn 
1               5   


<210>  419
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 2 (FWR2) sequence

<400>  419
tgggtgaagc agagtcatgc aaagagtcta gagtggattg ga                          42


<210>  420
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 2 (FWR2) sequence

<400>  420

Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  421
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  421
gttattagta ctttctctgg taatacaaac ttcaaccaga agtttaaggg c                51


<210>  422
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  422

Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  423
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  423
aaggccacaa tgactgtaga caaatcctcc agcacagcct atatggaact tgccagattg       60

acatctgagg attctgccat gtattactgt gcaaga                                 96


<210>  424
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  424

Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  425
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  425
tcggattact acggcccata ctttgactac                                        30


<210>  426
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  426

Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10  


<210>  427

<400>  427
000

<210>  428

<400>  428
000

<210>  429

<400>  429
000

<210>  430

<400>  430
000

<210>  431

<400>  431
000

<210>  432

<400>  432
000

<210>  433

<400>  433
000

<210>  434

<400>  434
000

<210>  435

<400>  435
000

<210>  436

<400>  436
000

<210>  437

<400>  437
000

<210>  438

<400>  438
000

<210>  439
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable region sequence from IGHV118*04

<400>  439
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagc         357


<210>  440
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable region sequence from IGHV118*04

<400>  440

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  441
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  441
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc                                        90


<210>  442
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 1 (FWR1) acid 
       sequence

<400>  442

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  443
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  443
gactacgcca tgaac                                                        15


<210>  444
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  444

Asp Tyr Ala Met Asn 
1               5   


<210>  445
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  445
tgggtgcgac aggcccctgg acaagggctt gagtggatgg ga                          42


<210>  446
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 2 (FWR2) acid 
       sequence

<400>  446

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  447
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  447
gtgatcagca ccttcagcgg taacacaaac ttcaaccaga agttcaaggg c                51


<210>  448
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  448

Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  449
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  449
agagtcacca tgaccacaga cacatccacg agcacagcct acatggagct gaggagcctg       60

agatctgacg acacggccgt gtattactgt gcgaga                                 96


<210>  450
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable framework region 3 (FWR3) acid 
       sequence

<400>  450

Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  451
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  451
agcgactact acggcccata cttcgactac                                        30


<210>  452
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  452

Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr 
1               5                   10  


<210>  453
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG1 heavy chain sequence

<400>  453
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgct      360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgacagtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaatga taa                                  1353


<210>  454
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG1 heavy chain sequence

<400>  454

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  455
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG2 heavy chain sequence

<400>  455
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc gactacgcca tgaactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtg atcagcacct tcagcggtaa cacaaacttc      180

aaccagaagt tcaagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagaagcgac      300

tactacggcc catacttcga ctactggggc cagggcacca ccctgaccgt gtccagcgcc      360

tccaccaagg gcccatcggt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ctctgaccag cggcgtgcac accttcccag ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca acttcggcac ccagacctac      600

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcgcaaa      660

tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg      780

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg      900

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag      960

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaatagta a                                               1341


<210>  456
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 IgG2 heavy chain sequence

<400>  456

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ser Thr Phe Ser Gly Asn Thr Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Tyr Tyr Gly Pro Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  457

<400>  457
000

<210>  458
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Light Chain variable region sequence

<400>  458
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaccattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

aacagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaa                                336


<210>  459
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 Light Chain variable region sequence

<400>  459

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  460
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 1 (FWR1) sequence

<400>  460
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  461
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 1 (FWR1) sequence

<400>  461

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  462
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  462
agatctagtc agaccattgt acatagtaat ggaaacacct atttagaa                    48


<210>  463
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  463

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  464
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 2 (FWR2) sequence

<400>  464
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  465
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 2 (FWR2) sequence

<400>  465

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  466
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  466
aaagtttcca accgattttc t                                                 21


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  467

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  468
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 3 (FWR3) sequence

<400>  468
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcaac       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  469
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable framework region 3 (FWR3) sequence

<400>  469

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  470
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  470
tttcaaggtt cacatgttcc attcacg                                           27


<210>  471
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C3 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  471

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable region sequence from IGKV229*03

<400>  486
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      300

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ct                         342


<210>  487
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable region sequence from IGKV229*03

<400>  487

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  488
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  488
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgc                                                               69


<210>  489
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 1 (FWR1) acid 
       sequence

<400>  489

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  490
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  490
ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggag                     47


<210>  491
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  491

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  492
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 2 (FWR2) acid 
       sequence

<400>  492
tggtacctgc agaagccagg ccagtctcca cagctcctga tctat                       45


<210>  493
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 2 (FWR2) acid 
       sequence

<400>  493

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  494
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  494
aaggtttcca accggttctc t                                                 21


<210>  495
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  495

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  496
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  496
ggagtgccag ataggttcag tggcagcggg tcagggacag atttcacact gaaaatcagc       60

cgggtggagg ctgaggatgt tggggtttat tactgc                                 96


<210>  497
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable framework region 3 (FWR3) acid 
       sequence

<400>  497

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  498
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  498
ttccaaggta gccacgtgcc tttcacc                                           27


<210>  499
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  499

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  500
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 lambda light chain sequence

<400>  500
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      300

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ctggtcagcc caaggctgcc      360

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg      420

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatagc      480

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac      540

gcggccagca gctatctgag cctgacgcct gagcagtgga agtcccacag aagctacagc      600

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      660

tagtaa                                                                 666


<210>  501
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 lambda light chain sequence

<400>  501

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
    130                 135                 140                 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
145                 150                 155                 160 


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
                165                 170                 175     


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
            180                 185                 190         


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
        195                 200                 205             


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 220 


<210>  502
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C3 Kappa light chain

<400>  502
gatattgtga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc       60

atctcctgca ggtctagtca gaccattgtc catagtaatg gaaacaccta tttggagtgg      120

tacctgcaga agccaggcca gtctccacag ctcctgatct ataaggtttc caaccggttc      180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc      240

agccgggtgg aggctgagga tgttggggtt tattactgct tccaaggtag ccacgtgcct      300

ttcaccttcg gcggagggac caaggtggag atcaaacgaa ctacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tagtaa                                                                 666


<210>  503
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C3 Kappa light chain

<400>  503

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  504

<400>  504
000

<210>  505
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable region sequence

<400>  505
gaagtgatgg tcgtggaaag cggcggtggt ctggtaaagc cggggggatc ccttaagctt       60

tcttgcgccg catccgggtt cacgttctcc ggctatgcca tgtcctgggt ccgacagact      120

cccgaaaagc gcttggaatg ggtggccact atctcctccg gggggacgta catctactac      180

cccgacagtg tgaaaggaag atttacaata tctcgcgaca acgcaaaaaa taccttgtat      240

cttcaaatga gctccctgcg gtcagaggac actgccatgt actattgcgc ccgcctgggc      300

ggcgacaatt actatgagta t                                                321


<210>  506
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable region sequence

<400>  506

Glu Val Met Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
            100                 105         


<210>  507
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  507
ggctatgcca tgtcc                                                        15


<210>  508
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  508

Gly Tyr Ala Met Ser 
1               5   


<210>  509
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  509
actatctcct ccggggggac gtacatctac taccccgaca gtgtgaaagg a                51


<210>  510
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  510

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  511
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  511
ctgggcggcg acaattacta tgagtat                                           27


<210>  512
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 heavy chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  512

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
1               5                   


<210>  513

<400>  513
000

<210>  514

<400>  514
000

<210>  515

<400>  515
000

<210>  516

<400>  516
000

<210>  517

<400>  517
000

<210>  518

<400>  518
000

<210>  519

<400>  519
000

<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable region sequence from IGHV321*04

<400>  525
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctcc            354


<210>  526
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable region sequence from IGHV321*04

<400>  526

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  527
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  527
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt                                        90


<210>  528
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 1 (FWR1) 
       sequence

<400>  528

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  529
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  529
ggctatgcca tgagc                                                        15


<210>  530
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  530

Gly Tyr Ala Met Ser 
1               5   


<210>  531
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  531
tgggtccgcc aggctccagg gaaggggctg gagtgggtct ca                          42


<210>  532
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 2 (FWR2) 
       sequence

<400>  532

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  533
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  533
accattagta gtggcggaac ctacatatac taccctgact cagtgaaggg c                51


<210>  534
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  534

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  535
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  535
cgattcacca tctccagaga caacgccaag aactcactgt atctgcaaat gaacagcctg       60

agagccgagg acacggccgt gtattactgt gcgaga                                 96


<210>  536
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable framework region 3 (FWR3) 
       sequence

<400>  536

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  537
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  537
ctgggcggcg ataactatta tgaatat                                           27


<210>  538
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 heavy chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  538

Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
1               5                   


<210>  539
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG1 heavy chain sequence

<400>  539
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gacagtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatgataa                                      1350


<210>  540
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG1 heavy chain sequence

<400>  540

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  541
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG2 heavy chain sequence

<400>  541
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cctgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagactgggc      300

ggcgataact attatgaata ttggggcaaa gggaccacgg tcaccgtctc ctccgcctcc      360

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      420

gccgccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc      600

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt      660

tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc      720

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      780

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag      840

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc      900

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      960

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc     1020

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc     1200

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1320

tctccgggta aatagtaa                                                   1338


<210>  542
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 IgG2 heavy chain sequence

<400>  542

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  543
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable region sequence

<400>  543
gacatcgtca ttacgcagac ccctgccagt cttgccgttt ctctgggcca gagggccact       60

atcagttaca gggcgagtaa gtctgtgagt accagcggct atagttacat gcattggaac      120

cagcagaaac cgggacagcc accacgcctg cttatttatc tggtgtctaa tcttgagtcc      180

ggggtgcccg ccaggttcag cggcagcggc tctgggaccg acttcacact caacattcat      240

ccagtggaag aagaggacgc tgctacatac tactgtcaac acattcggga actgaccagg      300

agtgaa                                                                 306


<210>  544
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable region sequence

<400>  544

Asp Ile Val Ile Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu 
            100         


<210>  545
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  545
agggcgagta agtctgtgag taccagcggc tatagttaca tgcat                       45


<210>  546
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       1 (CDR1) sequence

<400>  546

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  547
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  547
ctggtgtcta atcttgagtc c                                                 21


<210>  548
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       2 (CDR2) sequence

<400>  548

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  549
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  549
caacacattc gggaactgac caggagtgaa                                        30


<210>  550
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse C8 light chain variable complementarity determining region 
       3 (CDR3) sequence

<400>  550

Gln His Ile Arg Glu Leu Thr Arg Ser Glu 
1               5                   10  


<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553

<400>  553
000

<210>  554

<400>  554
000

<210>  555

<400>  555
000

<210>  556

<400>  556
000

<210>  557

<400>  557
000

<210>  558

<400>  558
000

<210>  559

<400>  559
000

<210>  560

<400>  560
000

<210>  561

<400>  561
000

<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable region sequence from NCBI 
       germline z00023

<400>  565
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca gggccagcaa gagtgttagc accagcggct acagctacat gcactggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacc tggtgtctaa cctggaatcc      180

ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg ctgaagatgt ggcagtttat tactgtcaac acattcggga actgaccagg      300

agtgaattcg gcggagggac caaggtggag atcaaacgaa ct                         342


<210>  566
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable region sequence from NCBI 
       germline z00023

<400>  566

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr 
        


<210>  567
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 1 (FWR1) 
       sequence

<400>  567
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgc                                                               69


<210>  568
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 1 (FWR1) 
       sequence

<400>  568

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  569
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  569
agggccagca agagtgttag caccagcggc tacagctaca tg                          42


<210>  570
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 1 (CDR1) sequence

<400>  570

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met 
1               5                   10                  


<210>  571
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 2 (FWR2) 
       sequence

<400>  571
cactggtacc agcagaaacc aggacagcct cctaagctgc tcatttac                    48


<210>  572
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 2 (FWR2) 
       sequence

<400>  572

His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15      


<210>  573
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  573
ctggtgtcta acctggaatc c                                                 21


<210>  574
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 2 (CDR2) sequence

<400>  574

Leu Val Ser Asn Leu Glu Ser 
1               5           


<210>  575
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 3 (FWR3) 
       sequence

<400>  575
ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc       60

agcctgcagg ctgaagatgt ggcagtttat tactgt                                 96


<210>  576
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable framework region 3 (FWR3) 
       sequence

<400>  576

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  577
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  577
caacacattc gggaactgac caggagtgaa                                        30


<210>  578
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 light chain variable complementarity determining 
       region 3 (CDR3) sequence

<400>  578

Gln His Ile Arg Glu Leu Thr Arg Ser Glu 
1               5                   10  


<210>  579
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Lambda light chain sequence

<400>  579
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca gggccagcaa gagtgttagc accagcggct acagctacat gcactggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacc tggtgtctaa cctggaatcc      180

ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg ctgaagatgt ggcagtttat tactgtcaac acattcggga actgaccagg      300

agtgaattcg gcggagggac caaggtggag atcaaacgaa ctggtcagcc caaggctgcc      360

ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa ggccacactg      420

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatagc      480

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac      540

gcggccagca gctatctgag cctgacgcct gagcagtgga agtcccacag aagctacagc      600

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac agaatgttca      660

tagtaa                                                                 666


<210>  580
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Lambda light chain sequence

<400>  580

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
        115                 120                 125             


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
    130                 135                 140                 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
145                 150                 155                 160 


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
                165                 170                 175     


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
            180                 185                 190         


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
        195                 200                 205             


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 220 


<210>  581
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Kappa light chain sequence

<400>  581
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca gggccagcaa gagtgttagc accagcggct acagctacat gcactggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacc tggtgtctaa cctggaatcc      180

ggggtccctg accgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg ctgaagatgt ggcagtttat tactgtcaac acattcggga actgaccagg      300

agtgaattcg gcggagggac caaggtggag atcaaacgaa ctacggtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tagtaa                                                                 666


<210>  582
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized C8 Kappa light chain sequence

<400>  582

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  583

<400>  583
000

<210>  584
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8 sequence

<400>  584
gaggtccagc tggttgagag tggcggtggg ctggttaagc ctggcggctc cctgcggctg       60

agctgcgccg cgagtggatt tactttcagc cgatatggga tgagttgggt gcggcaagct      120

cccgggaaga ggctggaatg ggtctcaaca atctccgggg ggggcactta catctattac      180

cccgactcag tcaaggggag atttaccatt tcacgagaca acgctaagaa taccctgtat      240

ttgcagatga attctctgag agcagaggac acagctgttt actattgtac ccgcgacaac      300

tatggcagga actacgacta cggtatggac tattggggac aagggacatt ggttacagtg      360

agcagtggcg gcgggggcag cggaggagga ggcagcggtg gggggggcag cgagatagtg      420

ctcacgcagt cacccgcgac tctcagtctc tcacctgggg aacgagctac cctgacgtgc      480

tctgctacct cctcagtgtc atatattcac tggtatcagc aacggcccgg gcagtcccct      540

agattgctca tttatagtac ctctaatctg gcctcaggta tccctgcacg attttctgga      600

tctggttcag gttctgatta caccctcact atctctagcc tggagcctga agactttgcc      660

gtttattact gccagcagag gtctagctcc ccattcacct ttgggagtgg gaccaaggtt      720

gaaattaaaa cgacaacccc ggcccccaga ccaccaacgc cagcccccac catcgccagc      780

caacccctgt ctctgagacc agaagcctgt aggcctgccg ccggtggagc tgtgcacaca      840

agaggactgg atttcgcctg tgatatctac atttgggccc cgctcgcagg cacatgtgga      900

gtgctcctcc tctccctggt gattaccctg tactgctgat aa                         942


<210>  585
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART E6 CD8 sequence

<400>  585

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    290                 295                 300                 


Ser Leu Val Ile Thr Leu Tyr Cys 
305                 310         


<210>  586
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8 CD8 sequence - NCD8lshuMNC2scFvCD8ecd fragment CD8 
       transmembraneC

<400>  586
gaagtgcagc tcgtagagag tggcggggga ctggtgaagc ccggtggaag cctcagactc       60

agttgcgccg cctcaggttt cactttttca ggttacgcca tgtcctgggt aagacaggca      120

ccggggaaag gactcgagtg ggtgtctact atcagctcag gaggcactta tatatattat      180

cctgactctg taaaaggccg atttacgatt tctcgcgaca atgcaaagaa ctccctctac      240

ctccaaatga acagtcttag ggcagaagac actgctgtat actattgtgc acgcctcggc      300

ggcgacaact actacgagta ctttgacgtg tgggggaaag ggactaccgt gacagtttca      360

agcggaggag gtggctcagg tggaggcggg tcaggggggg gaggaagtga tattgtgctc      420

acacaatccc cagcctccct ggctgtgtct cccggccaac gcgctacaat tacatgtcgg      480

gcctccaaaa gcgtgagcac cagcggctac agctacatgc actggtatca acagaaacca      540

ggacaacccc ccaaactgtt gatttatctc gcttcaaact tggagtccgg cgtgcctgcg      600

cgcttttcag ggagtgggag cggcacagat tttacgctga ctatcaaccc cgtagaagca      660

aacgatacag cgaattatta ttgtcaacat tcccgggaac tcccctttac gttcggcggg      720

ggcacaaagg tcgaaattaa gagaaccacg acaaccccgg cccccagacc accaacgcca      780

gcccccacca tcgccagcca acccctgtct ctgagaccag aagcctgtag gcctgccgcc      840

ggtggagctg tgcacacaag aggactggat ttcgcctgtg atatctacat ttgggccccg      900

ctcgcaggca catgtggagt gctcctcctc tccctggtga ttaccctgta ctgctgataa      960


<210>  587
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8 CD8 sequence - NCD8lshuMNC2scFvCD8ecd fragment CD8 
       transmembraneC

<400>  587

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Thr Pro Ala Pro Arg 
                245                 250                 255     


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
            260                 265                 270         


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
        275                 280                 285             


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
    290                 295                 300                 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
305                 310                 315             


<210>  588
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/41BB sequence - N CD8 transmembrane 41BBC

<400>  588
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaaa aggggccgca aaaaactcct ttacattttt      240

aagcagcctt ttatgaggcc agtacagacg actcaagagg aagacgggtg ctcatgccgc      300

tttcctgagg aggaggaagg agggtgcgaa ctgtgataa                             339


<210>  589
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/41BB sequence - N CD8 transmembrane 41BBC

<400>  589

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            100                 105                 110     


<210>  590
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD28 sequence - N CD8 transmembrane CD28C

<400>  590
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaga agcaagcggt ctcggctcct gcattctgat      240

tacatgaaca tgaccccaag aagaccaggc cccaccagga aacattacca gccctacgct      300

ccgccacgcg acttcgctgc ctaccggtcc tgataa                                336


<210>  591
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD28 sequence - N CD8 transmembrane CD28C

<400>  591

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105                 110 


<210>  592
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD3z sequence - N CD8 transmembrane CD3zetaC

<400>  592
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgccgc gttaagttct cccgatcagc cgacgcgcct      240

gcttacaagc agggccagaa ccaactgtac aacgagctga atctcggtag acgggaagag      300

tacgacgtgt tggacaaacg gagaggccgc gacccagaaa tgggcggcaa gcctcgcagg      360

aaaaaccccc aggagggact gtacaatgag ttgcagaaag ataagatggc agaagcttat      420

agcgagatcg gaatgaaggg ggaaaggaga cgagggaaag gacacgacgg cctttatcag      480

ggcctgtcca cagcaacaaa agatacgtat gacgccctcc atatgcaggc acttccacca      540

cggtgataa                                                              549


<210>  593
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD3z sequence - N CD8 transmembrane CD3zetaC

<400>  593

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
65                  70                  75                  80  


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                85                  90                  95      


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            100                 105                 110         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        115                 120                 125             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    130                 135                 140                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
145                 150                 155                 160 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                165                 170                 175     


Ala Leu Pro Pro Arg 
            180     


<210>  594
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/CD3z sequence - N CD8 transmembrane CD28 CD3zetaC

<400>  594
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaga agcaagcggt ctcggctcct gcattctgat      240

tacatgaaca tgaccccaag aagaccaggc cccaccagga aacattacca gccctacgct      300

ccgccacgcg acttcgctgc ctaccggtcc cgcgttaagt tctcccgatc agccgacgcg      360

cctgcttaca agcagggcca gaaccaactg tacaacgagc tgaatctcgg tagacgggaa      420

gagtacgacg tgttggacaa acggagaggc cgcgacccag aaatgggcgg caagcctcgc      480

aggaaaaacc cccaggaggg actgtacaat gagttgcaga aagataagat ggcagaagct      540

tatagcgaga tcggaatgaa gggggaaagg agacgaggga aaggacacga cggcctttat      600

cagggcctgt ccacagcaac aaaagatacg tatgacgccc tccatatgca ggcacttcca      660

ccacggtgat aa                                                          672


<210>  595
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/CD3z sequence - N CD8 transmembrane CD28 CD3zetaC

<400>  595

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


<210>  596
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/41BB/CD3z sequence - N CD8 transmembrane 41BB CD3zetaC

<400>  596
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaaa aggggccgca aaaaactcct ttacattttt      240

aagcagcctt ttatgaggcc agtacagacg actcaagagg aagacgggtg ctcatgccgc      300

tttcctgagg aggaggaagg agggtgcgaa ctgcgcgtta agttctcccg atcagccgac      360

gcgcctgctt acaagcaggg ccagaaccaa ctgtacaacg agctgaatct cggtagacgg      420

gaagagtacg acgtgttgga caaacggaga ggccgcgacc cagaaatggg cggcaagcct      480

cgcaggaaaa acccccagga gggactgtac aatgagttgc agaaagataa gatggcagaa      540

gcttatagcg agatcggaat gaagggggaa aggagacgag ggaaaggaca cgacggcctt      600

tatcagggcc tgtccacagc aacaaaagat acgtatgacg ccctccatat gcaggcactt      660

ccaccacggt gataa                                                       675


<210>  597
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/41BB/CD3z sequence - N CD8 transmembrane 41BB CD3zetaC

<400>  597

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        115                 120                 125             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             


<210>  598
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/41BB/CD3z sequence - N CD8 transmembrane CD28 41BB 
       CD3zetaC

<400>  598
acgacaaccc cggcccccag accaccaacg ccagccccca ccatcgccag ccaacccctg       60

tctctgagac cagaagcctg taggcctgcc gccggtggag ctgtgcacac aagaggactg      120

gatttcgcct gtgatatcta catttgggcc ccgctcgcag gcacatgtgg agtgctcctc      180

ctctccctgg tgattaccct gtactgcaga agcaagcggt ctcggctcct gcattctgat      240

tacatgaaca tgaccccaag aagaccaggc cccaccagga aacattacca gccctacgct      300

ccgccacgcg acttcgctgc ctaccggtcc aaaaggggcc gcaaaaaact cctttacatt      360

tttaagcagc cttttatgag gccagtacag acgactcaag aggaagacgg gtgctcatgc      420

cgctttcctg aggaggagga aggagggtgc gaactgcgcg ttaagttctc ccgatcagcc      480

gacgcgcctg cttacaagca gggccagaac caactgtaca acgagctgaa tctcggtaga      540

cgggaagagt acgacgtgtt ggacaaacgg agaggccgcg acccagaaat gggcggcaag      600

cctcgcagga aaaaccccca ggagggactg tacaatgagt tgcagaaaga taagatggca      660

gaagcttata gcgagatcgg aatgaagggg gaaaggagac gagggaaagg acacgacggc      720

ctttatcagg gcctgtccac agcaacaaaa gatacgtatg acgccctcca tatgcaggca      780

cttccaccac ggtgataa                                                    798


<210>  599
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8/CD28/41BB/CD3z sequence - N CD8 transmembrane CD28 41BB 
       CD3zetaC

<400>  599

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
            100                 105                 110         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        115                 120                 125             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    130                 135                 140                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
145                 150                 155                 160 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                165                 170                 175     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            180                 185                 190         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        195                 200                 205             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    210                 215                 220                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
225                 230                 235                 240 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                245                 250                 255     


His Met Gln Ala Leu Pro Pro Arg 
            260                 


<210>  600

<400>  600
000

<210>  601

<400>  601
000

<210>  602

<400>  602
000

<210>  603

<400>  603
000

<210>  604

<400>  604
000

<210>  605

<400>  605
000

<210>  606

<400>  606
000

<210>  607

<400>  607
000

<210>  608
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/CD28/CD3z sequence - NCD8lshuMNC2scFvCD8ecd 
       fragment CD8 transmembrane CD28 CD3zetaC

<400>  608
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaga     1020

agcaagcggt ctcggctcct gcattctgat tacatgaaca tgaccccaag aagaccaggc     1080

cccaccagga aacattacca gccctacgct ccgccacgcg acttcgctgc ctaccggtcc     1140

cgcgttaagt tctcccgatc agccgacgcg cctgcttaca agcagggcca gaaccaactg     1200

tacaacgagc tgaatctcgg tagacgggaa gagtacgacg tgttggacaa acggagaggc     1260

cgcgacccag aaatgggcgg caagcctcgc aggaaaaacc cccaggaggg actgtacaat     1320

gagttgcaga aagataagat ggcagaagct tatagcgaga tcggaatgaa gggggaaagg     1380

agacgaggga aaggacacga cggcctttat cagggcctgt ccacagcaac aaaagatacg     1440

tatgacgccc tccatatgca ggcacttcca ccacggtgat aa                        1482


<210>  609
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/CD28/CD3z sequence - NCD8lshuMNC2scFvCD8ecd 
       fragment CD8 transmembrane CD28 CD3zetaC

<400>  609

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  610
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/41BB/CD3z sequence #13 - NCD8lshuMNC2scFvCD8ecd 
       fragment CD8 transmembrane 41BB CD3zetaC

<400>  610
atggccttgc cagtgacggc cctgctgctg ccattggctc ttctgttgca cgctgccagg       60

cctgaagtgc agctcgtaga gagtggcggg ggactggtga agcccggtgg aagcctcaga      120

ctcagttgcg ccgcctcagg tttcactttt tcaggttacg ccatgtcctg ggtaagacag      180

gcaccgggga aaggactcga gtgggtgtct actatcagct caggaggcac ttatatatat      240

tatcctgact ctgtaaaagg ccgatttacg atttctcgcg acaatgcaaa gaactccctc      300

tacctccaaa tgaacagtct tagggcagaa gacactgctg tatactattg tgcacgcctc      360

ggcggcgaca actactacga gtactttgac gtgtggggga aagggactac cgtgacagtt      420

tcaagcggag gaggtggctc aggtggaggc gggtcagggg ggggaggaag tgatattgtg      480

ctcacacaat ccccagcctc cctggctgtg tctcccggcc aacgcgctac aattacatgt      540

cgggcctcca aaagcgtgag caccagcggc tacagctaca tgcactggta tcaacagaaa      600

ccaggacaac cccccaaact gttgatttat ctcgcttcaa acttggagtc cggcgtgcct      660

gcgcgctttt cagggagtgg gagcggcaca gattttacgc tgactatcaa ccccgtagaa      720

gcaaacgata cagcgaatta ttattgtcaa cattcccggg aactcccctt tacgttcggc      780

gggggcacaa aggtcgaaat taagagaacc acgacaaccc cggcccccag accaccaacg      840

ccagccccca ccatcgccag ccaacccctg tctctgagac cagaagcctg taggcctgcc      900

gccggtggag ctgtgcacac aagaggactg gatttcgcct gtgatatcta catttgggcc      960

ccgctcgcag gcacatgtgg agtgctcctc ctctccctgg tgattaccct gtactgcaaa     1020

aggggccgca aaaaactcct ttacattttt aagcagcctt ttatgaggcc agtacagacg     1080

actcaagagg aagacgggtg ctcatgccgc tttcctgagg aggaggaagg agggtgcgaa     1140

ctgcgcgtta agttctcccg atcagccgac gcgcctgctt acaagcaggg ccagaaccaa     1200

ctgtacaacg agctgaatct cggtagacgg gaagagtacg acgtgttgga caaacggaga     1260

ggccgcgacc cagaaatggg cggcaagcct cgcaggaaaa acccccagga gggactgtac     1320

aatgagttgc agaaagataa gatggcagaa gcttatagcg agatcggaat gaagggggaa     1380

aggagacgag ggaaaggaca cgacggcctt tatcagggcc tgtccacagc aacaaaagat     1440

acgtatgacg ccctccatat gcaggcactt ccaccacggt gataa                     1485


<210>  611
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/41BB/CD3z sequence #13 - NCD8lshuMNC2scFvCD8ecd 
       fragment CD8 transmembrane 41BB CD3zetaC

<400>  611

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  612

<400>  612
000

<210>  613

<400>  613
000

<210>  614

<400>  614
000

<210>  615

<400>  615
000

<210>  616

<400>  616
000

<210>  617

<400>  617
000

<210>  618

<400>  618
000

<210>  619

<400>  619
000

<210>  620
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 truncated extra cellular domain sequence

<400>  620

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            20                  25                  30          


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
        35                  40              


<210>  621
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 truncated extra cellular domain sequence

<400>  621

Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 
1               5                   10                  15      


Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala 
            20                  25                  30          


Ser Arg Tyr 
        35  


<210>  622
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 truncated extra cellular domain sequence

<400>  622

Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
1               5                   10                  15      


Val Glu Thr Gln Phe Asn Gln Tyr 
            20                  


<210>  623
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 truncated extra cellular domain sequence

<400>  623

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn 
            20                  


<210>  624
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  624
attctaagct tgggccacca tggaactg                                          28


<210>  625
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  625
tctagagttt aaacttacta tttacccgga gacagggaga g                           41


<210>  626
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  626
agtatggccc agccggccga ggtgcagctg gtggagtctg g                           41


<210>  627
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  627
tagaaggcac agtcgaggct gatcag                                            26


<210>  628
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  628
attctaagct tgggccacca tggaagc                                           27


<210>  629
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  629
tctagagttt aaacttacta acactctccc ctgttgaagc                             40


<210>  630
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  630
agtatggccc agccggccga aattgtgttg acacagtctc cag                         43


<210>  631
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  631
tagaaggcac agtcgaggct gatcag                                            26


<210>  632
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  632
actgtcatat ggaggtgcag ctggtggagt ctg                                    33


<210>  633
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  633
actgtctcga gtttaatttc cactttggtg ccgctgc                                37


<210>  634
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  634
actgtcatat ggaggtgcag ctggtggagt ctg                                    33


<210>  635
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  635
actgtaccgg ttttaatttc cactttggtg ccgctgc                                37


<210>  636
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  636
cttcttcctc aggagcaagc tcaccgtgg                                         29


<210>  637
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  637
gagccgtcgg agtccagc                                                     18


<210>  638
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  638
gcacctgaac tcctgggg                                                     18


<210>  639
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  639
tttaatttcc actttggtgc cg                                                22


<210>  640
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  640
cgcggctagc ttaagcttgg taccgagggc ca                                     32


<210>  641
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  641
cgcggcggcc gcctgatcag cgggtttaaa cttatc                                 36


<210>  642
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP9 sequence

<400>  642
atgagcctct ggcagcccct ggtcctggtg ctcctggtgc tgggctgctg ctttgctgcc       60

cccagacagc gccagtccac ccttgtgctc ttccctggag acctgagaac caatctcacc      120

gacaggcagc tggcagagga atacctgtac cgctatggtt acactcgggt ggcagagatg      180

cgtggagagt cgaaatctct ggggcctgcg ctgctgcttc tccagaagca actgtccctg      240

cccgagaccg gtgagctgga tagcgccacg ctgaaggcca tgcgaacccc acggtgcggg      300

gtcccagacc tgggcagatt ccaaaccttt gagggcgacc tcaagtggca ccaccacaac      360

atcacctatt ggatccaaaa ctactcggaa gacttgccgc gggcggtgat tgacgacgcc      420

tttgcccgcg ccttcgcact gtggagcgcg gtgacgccgc tcaccttcac tcgcgtgtac      480

agccgggacg cagacatcgt catccagttt ggtgtcgcgg agcacggaga cgggtatccc      540

ttcgacggga aggacgggct cctggcacac gcctttcctc ctggccccgg cattcaggga      600

gacgcccatt tcgacgatga cgagttgtgg tccctgggca agggcgtcgt ggttccaact      660

cggtttggaa acgcagatgg cgcggcctgc cacttcccct tcatcttcga gggccgctcc      720

tactctgcct gcaccaccga cggtcgctcc gacggcttgc cctggtgcag taccacggcc      780

aactacgaca ccgacgaccg gtttggcttc tgccccagcg agagactcta cacccaggac      840

ggcaatgctg atgggaaacc ctgccagttt ccattcatct tccaaggcca atcctactcc      900

gcctgcacca cggacggtcg ctccgacggc taccgctggt gcgccaccac cgccaactac      960

gaccgggaca agctcttcgg cttctgcccg acccgagctg actcgacggt gatggggggc     1020

aactcggcgg gggagctgtg cgtcttcccc ttcactttcc tgggtaagga gtactcgacc     1080

tgtaccagcg agggccgcgg agatgggcgc ctctggtgcg ctaccacctc gaactttgac     1140

agcgacaaga agtggggctt ctgcccggac caaggataca gtttgttcct cgtggcggcg     1200

catgagttcg gccacgcgct gggcttagat cattcctcag tgccggaggc gctcatgtac     1260

cctatgtacc gcttcactga ggggcccccc ttgcataagg acgacgtgaa tggcatccgg     1320

cacctctatg gtcctcgccc tgaacctgag ccacggcctc caaccaccac cacaccgcag     1380

cccacggctc ccccgacggt ctgccccacc ggacccccca ctgtccaccc ctcagagcgc     1440

cccacagctg gccccacagg tcccccctca gctggcccca caggtccccc cactgctggc     1500

ccttctacgg ccactactgt gcctttgagt ccggtggacg atgcctgcaa cgtgaacatc     1560

ttcgacgcca tcgcggagat tgggaaccag ctgtatttgt tcaaggatgg gaagtactgg     1620

cgattctctg agggcagggg gagccggccg cagggcccct tccttatcgc cgacaagtgg     1680

cccgcgctgc cccgcaagct ggactcggtc tttgaggagc ggctctccaa gaagcttttc     1740

ttcttctctg ggcgccaggt gtgggtgtac acaggcgcgt cggtgctggg cccgaggcgt     1800

ctggacaagc tgggcctggg agccgacgtg gcccaggtga ccggggccct ccggagtggc     1860

agggggaaga tgctgctgtt cagcgggcgg cgcctctgga ggttcgacgt gaaggcgcag     1920

atggtggatc cccggagcgc cagcgaggtg gaccggatgt tccccggggt gcctttggac     1980

acgcacgacg tcttccagta ccgagagaaa gcctatttct gccaggaccg cttctactgg     2040

cgcgtgagtt cccggagtga gttgaaccag gtggaccaag tgggctacgt gacctatgac     2100

atcctgcagt gccctgagga cgattacaag gatgacgacg ataagtgata a              2151


<210>  643
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9 sequence

<400>  643

Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 
1               5                   10                  15      


Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 
            20                  25                  30          


Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 
        35                  40                  45              


Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 
    50                  55                  60                  


Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 
65                  70                  75                  80  


Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 
                85                  90                  95      


Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 
            100                 105                 110         


Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 
        115                 120                 125             


Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 
    130                 135                 140                 


Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 
145                 150                 155                 160 


Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 
                165                 170                 175     


Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 
            180                 185                 190         


Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 
        195                 200                 205             


Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 
    210                 215                 220                 


Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 
225                 230                 235                 240 


Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 
                245                 250                 255     


Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 
            260                 265                 270         


Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 
        275                 280                 285             


Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 
    290                 295                 300                 


Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 
305                 310                 315                 320 


Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 
                325                 330                 335     


Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 
            340                 345                 350         


Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 
        355                 360                 365             


Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 
    370                 375                 380                 


Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 
385                 390                 395                 400 


His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 
                405                 410                 415     


Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 
            420                 425                 430         


Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 
        435                 440                 445             


Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 
    450                 455                 460                 


Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 
465                 470                 475                 480 


Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 
                485                 490                 495     


Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 
            500                 505                 510         


Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 
        515                 520                 525             


Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 
    530                 535                 540                 


Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 
545                 550                 555                 560 


Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 
                565                 570                 575     


Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 
            580                 585                 590         


Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 
        595                 600                 605             


Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 
    610                 615                 620                 


Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 
625                 630                 635                 640 


Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 
                645                 650                 655     


Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 
            660                 665                 670         


Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 
        675                 680                 685             


Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 
    690                 695                 700                 


Pro Glu Asp Asp Tyr Lys Asp Asp Asp Asp Lys 
705                 710                 715 


<210>  644
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP9 catalytic domain

<400>  644
atgttccaaa cctttgaggg cgacctcaag tggcaccacc acaacatcac ctattggatc       60

caaaactact cggaagactt gccgcgggcg gtgattgacg acgcctttgc ccgcgccttc      120

gcactgtgga gcgcggtgac gccgctcacc ttcactcgcg tgtacagccg ggacgcagac      180

atcgtcatcc agtttggtgt cgcggagcac ggagacgggt atcccttcga cgggaaggac      240

gggctcctgg cacacgcctt tcctcctggc cccggcattc agggagacgc ccatttcgac      300

gatgacgagt tgtggtccct gggcaagggc gtcgtggttc caactcggtt tggaaacgca      360

gatggcgcgg cctgccactt ccccttcatc ttcgagggcc gctcctactc tgcctgcacc      420

accgacggtc gctccgacgg cttgccctgg tgcagtacca cggccaacta cgacaccgac      480

gaccggtttg gcttctgccc cagcgagaga ctctacaccc aggacggcaa tgctgatggg      540

aaaccctgcc agtttccatt catcttccaa ggccaatcct actccgcctg caccacggac      600

ggtcgctccg acggctaccg ctggtgcgcc accaccgcca actacgaccg ggacaagctc      660

ttcggcttct gcccgacccg agctgactcg acggtgatgg ggggcaactc ggcgggggag      720

ctgtgcgtct tccccttcac tttcctgggt aaggagtact cgacctgtac cagcgagggc      780

cgcggagatg ggcgcctctg gtgcgctacc acctcgaact ttgacagcga caagaagtgg      840

ggcttctgcc cggaccaagg atacagtttg ttcctcgtgg cggcgcatga gttcggccac      900

gcgctgggct tagatcattc ctcagtgccg gaggcgctca tgtaccctat gtaccgcttc      960

actgaggggc cccccttgca taaggacgac gtgaatggca tccggcacct ctatggtcct     1020

cgccctgaac ctgattacaa ggatgacgac gataagtgat aa                        1062


<210>  645
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9 catalytic domain

<400>  645

Met Phe Gln Thr Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile 
1               5                   10                  15      


Thr Tyr Trp Ile Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile 
            20                  25                  30          


Asp Asp Ala Phe Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro 
        35                  40                  45              


Leu Thr Phe Thr Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln 
    50                  55                  60                  


Phe Gly Val Ala Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp 
65                  70                  75                  80  


Gly Leu Leu Ala His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp 
                85                  90                  95      


Ala His Phe Asp Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val 
            100                 105                 110         


Val Pro Thr Arg Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro 
        115                 120                 125             


Phe Ile Phe Glu Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg 
    130                 135                 140                 


Ser Asp Gly Leu Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp 
145                 150                 155                 160 


Asp Arg Phe Gly Phe Cys Pro Ser Glu Arg Leu Tyr Thr Gln Asp Gly 
                165                 170                 175     


Asn Ala Asp Gly Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln 
            180                 185                 190         


Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp 
        195                 200                 205             


Cys Ala Thr Thr Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys 
    210                 215                 220                 


Pro Thr Arg Ala Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu 
225                 230                 235                 240 


Leu Cys Val Phe Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys 
                245                 250                 255     


Thr Ser Glu Gly Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser 
            260                 265                 270         


Asn Phe Asp Ser Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr 
        275                 280                 285             


Ser Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu 
    290                 295                 300                 


Asp His Ser Ser Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe 
305                 310                 315                 320 


Thr Glu Gly Pro Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His 
                325                 330                 335     


Leu Tyr Gly Pro Arg Pro Glu Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
            340                 345                 350         


<210>  646
<211>  2186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter (NFATc1P)

<400>  646
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagagg                                          2186


<210>  647
<211>  4349
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1PMMP9

<400>  647
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagaggtcta gagccaccat gagcctctgg cagcccctgg     2220

tcctggtgct cctggtgctg ggctgctgct ttgctgcccc cagacagcgc cagtccaccc     2280

ttgtgctctt ccctggagac ctgagaacca atctcaccga caggcagctg gcagaggaat     2340

acctgtaccg ctatggttac actcgggtgg cagagatgcg tggagagtcg aaatctctgg     2400

ggcctgcgct gctgcttctc cagaagcaac tgtccctgcc cgagaccggt gagctggata     2460

gcgccacgct gaaggccatg cgaaccccac ggtgcggggt cccagacctg ggcagattcc     2520

aaacctttga gggcgacctc aagtggcacc accacaacat cacctattgg atccaaaact     2580

actcggaaga cttgccgcgg gcggtgattg acgacgcctt tgcccgcgcc ttcgcactgt     2640

ggagcgcggt gacgccgctc accttcactc gcgtgtacag ccgggacgca gacatcgtca     2700

tccagtttgg tgtcgcggag cacggagacg ggtatccctt cgacgggaag gacgggctcc     2760

tggcacacgc ctttcctcct ggccccggca ttcagggaga cgcccatttc gacgatgacg     2820

agttgtggtc cctgggcaag ggcgtcgtgg ttccaactcg gtttggaaac gcagatggcg     2880

cggcctgcca cttccccttc atcttcgagg gccgctccta ctctgcctgc accaccgacg     2940

gtcgctccga cggcttgccc tggtgcagta ccacggccaa ctacgacacc gacgaccggt     3000

ttggcttctg ccccagcgag agactctaca cccaggacgg caatgctgat gggaaaccct     3060

gccagtttcc attcatcttc caaggccaat cctactccgc ctgcaccacg gacggtcgct     3120

ccgacggcta ccgctggtgc gccaccaccg ccaactacga ccgggacaag ctcttcggct     3180

tctgcccgac ccgagctgac tcgacggtga tggggggcaa ctcggcgggg gagctgtgcg     3240

tcttcccctt cactttcctg ggtaaggagt actcgacctg taccagcgag ggccgcggag     3300

atgggcgcct ctggtgcgct accacctcga actttgacag cgacaagaag tggggcttct     3360

gcccggacca aggatacagt ttgttcctcg tggcggcgca tgagttcggc cacgcgctgg     3420

gcttagatca ttcctcagtg ccggaggcgc tcatgtaccc tatgtaccgc ttcactgagg     3480

ggcccccctt gcataaggac gacgtgaatg gcatccggca cctctatggt cctcgccctg     3540

aacctgagcc acggcctcca accaccacca caccgcagcc cacggctccc ccgacggtct     3600

gccccaccgg accccccact gtccacccct cagagcgccc cacagctggc cccacaggtc     3660

ccccctcagc tggccccaca ggtcccccca ctgctggccc ttctacggcc actactgtgc     3720

ctttgagtcc ggtggacgat gcctgcaacg tgaacatctt cgacgccatc gcggagattg     3780

ggaaccagct gtatttgttc aaggatggga agtactggcg attctctgag ggcaggggga     3840

gccggccgca gggccccttc cttatcgccg acaagtggcc cgcgctgccc cgcaagctgg     3900

actcggtctt tgaggagcgg ctctccaaga agcttttctt cttctctggg cgccaggtgt     3960

gggtgtacac aggcgcgtcg gtgctgggcc cgaggcgtct ggacaagctg ggcctgggag     4020

ccgacgtggc ccaggtgacc ggggccctcc ggagtggcag ggggaagatg ctgctgttca     4080

gcgggcggcg cctctggagg ttcgacgtga aggcgcagat ggtggatccc cggagcgcca     4140

gcgaggtgga ccggatgttc cccggggtgc ctttggacac gcacgacgtc ttccagtacc     4200

gagagaaagc ctatttctgc caggaccgct tctactggcg cgtgagttcc cggagtgagt     4260

tgaaccaggt ggaccaagtg ggctacgtga cctatgacat cctgcagtgc cctgaggacg     4320

attacaagga tgacgacgat aagtgataa                                       4349


<210>  648
<211>  3260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1PMMP9cat

<400>  648
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagaggtcta gagccaccat gttccaaacc tttgagggcg     2220

acctcaagtg gcaccaccac aacatcacct attggatcca aaactactcg gaagacttgc     2280

cgcgggcggt gattgacgac gcctttgccc gcgccttcgc actgtggagc gcggtgacgc     2340

cgctcacctt cactcgcgtg tacagccggg acgcagacat cgtcatccag tttggtgtcg     2400

cggagcacgg agacgggtat cccttcgacg ggaaggacgg gctcctggca cacgcctttc     2460

ctcctggccc cggcattcag ggagacgccc atttcgacga tgacgagttg tggtccctgg     2520

gcaagggcgt cgtggttcca actcggtttg gaaacgcaga tggcgcggcc tgccacttcc     2580

ccttcatctt cgagggccgc tcctactctg cctgcaccac cgacggtcgc tccgacggct     2640

tgccctggtg cagtaccacg gccaactacg acaccgacga ccggtttggc ttctgcccca     2700

gcgagagact ctacacccag gacggcaatg ctgatgggaa accctgccag tttccattca     2760

tcttccaagg ccaatcctac tccgcctgca ccacggacgg tcgctccgac ggctaccgct     2820

ggtgcgccac caccgccaac tacgaccggg acaagctctt cggcttctgc ccgacccgag     2880

ctgactcgac ggtgatgggg ggcaactcgg cgggggagct gtgcgtcttc cccttcactt     2940

tcctgggtaa ggagtactcg acctgtacca gcgagggccg cggagatggg cgcctctggt     3000

gcgctaccac ctcgaacttt gacagcgaca agaagtgggg cttctgcccg gaccaaggat     3060

acagtttgtt cctcgtggcg gcgcatgagt tcggccacgc gctgggctta gatcattcct     3120

cagtgccgga ggcgctcatg taccctatgt accgcttcac tgaggggccc cccttgcata     3180

aggacgacgt gaatggcatc cggcacctct atggtcctcg ccctgaacct gattacaagg     3240

atgacgacga taagtgataa                                                 3260


<210>  649
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element

<400>  649
ggaggaaaaa ctgtttcata cagaaggcgt                                        30


<210>  650
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element repeats

<400>  650
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt                                        90


<210>  651
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV minimal promoter

<400>  651
aggtaggcgt gtacggtggg aggtctatat aagcagagct ggtttagtga accgtcagat       60

c                                                                       61


<210>  652
<211>  2326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATREmCMVMMP9

<400>  652
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt agatctagac tcaggtaggc gtgtacggtg      120

ggaggtctat ataagcagag ctggtttagt gaaccgtcag atctctagag ccaccatgag      180

cctctggcag cccctggtcc tggtgctcct ggtgctgggc tgctgctttg ctgcccccag      240

acagcgccag tccacccttg tgctcttccc tggagacctg agaaccaatc tcaccgacag      300

gcagctggca gaggaatacc tgtaccgcta tggttacact cgggtggcag agatgcgtgg      360

agagtcgaaa tctctggggc ctgcgctgct gcttctccag aagcaactgt ccctgcccga      420

gaccggtgag ctggatagcg ccacgctgaa ggccatgcga accccacggt gcggggtccc      480

agacctgggc agattccaaa cctttgaggg cgacctcaag tggcaccacc acaacatcac      540

ctattggatc caaaactact cggaagactt gccgcgggcg gtgattgacg acgcctttgc      600

ccgcgccttc gcactgtgga gcgcggtgac gccgctcacc ttcactcgcg tgtacagccg      660

ggacgcagac atcgtcatcc agtttggtgt cgcggagcac ggagacgggt atcccttcga      720

cgggaaggac gggctcctgg cacacgcctt tcctcctggc cccggcattc agggagacgc      780

ccatttcgac gatgacgagt tgtggtccct gggcaagggc gtcgtggttc caactcggtt      840

tggaaacgca gatggcgcgg cctgccactt ccccttcatc ttcgagggcc gctcctactc      900

tgcctgcacc accgacggtc gctccgacgg cttgccctgg tgcagtacca cggccaacta      960

cgacaccgac gaccggtttg gcttctgccc cagcgagaga ctctacaccc aggacggcaa     1020

tgctgatggg aaaccctgcc agtttccatt catcttccaa ggccaatcct actccgcctg     1080

caccacggac ggtcgctccg acggctaccg ctggtgcgcc accaccgcca actacgaccg     1140

ggacaagctc ttcggcttct gcccgacccg agctgactcg acggtgatgg ggggcaactc     1200

ggcgggggag ctgtgcgtct tccccttcac tttcctgggt aaggagtact cgacctgtac     1260

cagcgagggc cgcggagatg ggcgcctctg gtgcgctacc acctcgaact ttgacagcga     1320

caagaagtgg ggcttctgcc cggaccaagg atacagtttg ttcctcgtgg cggcgcatga     1380

gttcggccac gcgctgggct tagatcattc ctcagtgccg gaggcgctca tgtaccctat     1440

gtaccgcttc actgaggggc cccccttgca taaggacgac gtgaatggca tccggcacct     1500

ctatggtcct cgccctgaac ctgagccacg gcctccaacc accaccacac cgcagcccac     1560

ggctcccccg acggtctgcc ccaccggacc ccccactgtc cacccctcag agcgccccac     1620

agctggcccc acaggtcccc cctcagctgg ccccacaggt ccccccactg ctggcccttc     1680

tacggccact actgtgcctt tgagtccggt ggacgatgcc tgcaacgtga acatcttcga     1740

cgccatcgcg gagattggga accagctgta tttgttcaag gatgggaagt actggcgatt     1800

ctctgagggc agggggagcc ggccgcaggg ccccttcctt atcgccgaca agtggcccgc     1860

gctgccccgc aagctggact cggtctttga ggagcggctc tccaagaagc ttttcttctt     1920

ctctgggcgc caggtgtggg tgtacacagg cgcgtcggtg ctgggcccga ggcgtctgga     1980

caagctgggc ctgggagccg acgtggccca ggtgaccggg gccctccgga gtggcagggg     2040

gaagatgctg ctgttcagcg ggcggcgcct ctggaggttc gacgtgaagg cgcagatggt     2100

ggatccccgg agcgccagcg aggtggaccg gatgttcccc ggggtgcctt tggacacgca     2160

cgacgtcttc cagtaccgag agaaagccta tttctgccag gaccgcttct actggcgcgt     2220

gagttcccgg agtgagttga accaggtgga ccaagtgggc tacgtgacct atgacatcct     2280

gcagtgccct gaggacgatt acaaggatga cgacgataag tgataa                    2326


<210>  653
<211>  1237
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATREmCMVMMP9cat

<400>  653
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt agatctagac tcaggtaggc gtgtacggtg      120

ggaggtctat ataagcagag ctggtttagt gaaccgtcag atctctagag ccaccatgtt      180

ccaaaccttt gagggcgacc tcaagtggca ccaccacaac atcacctatt ggatccaaaa      240

ctactcggaa gacttgccgc gggcggtgat tgacgacgcc tttgcccgcg ccttcgcact      300

gtggagcgcg gtgacgccgc tcaccttcac tcgcgtgtac agccgggacg cagacatcgt      360

catccagttt ggtgtcgcgg agcacggaga cgggtatccc ttcgacggga aggacgggct      420

cctggcacac gcctttcctc ctggccccgg cattcaggga gacgcccatt tcgacgatga      480

cgagttgtgg tccctgggca agggcgtcgt ggttccaact cggtttggaa acgcagatgg      540

cgcggcctgc cacttcccct tcatcttcga gggccgctcc tactctgcct gcaccaccga      600

cggtcgctcc gacggcttgc cctggtgcag taccacggcc aactacgaca ccgacgaccg      660

gtttggcttc tgccccagcg agagactcta cacccaggac ggcaatgctg atgggaaacc      720

ctgccagttt ccattcatct tccaaggcca atcctactcc gcctgcacca cggacggtcg      780

ctccgacggc taccgctggt gcgccaccac cgccaactac gaccgggaca agctcttcgg      840

cttctgcccg acccgagctg actcgacggt gatggggggc aactcggcgg gggagctgtg      900

cgtcttcccc ttcactttcc tgggtaagga gtactcgacc tgtaccagcg agggccgcgg      960

agatgggcgc ctctggtgcg ctaccacctc gaactttgac agcgacaaga agtggggctt     1020

ctgcccggac caaggataca gtttgttcct cgtggcggcg catgagttcg gccacgcgct     1080

gggcttagat cattcctcag tgccggaggc gctcatgtac cctatgtacc gcttcactga     1140

ggggcccccc ttgcataagg acgacgtgaa tggcatccgg cacctctatg gtcctcgccc     1200

tgaacctgat tacaaggatg acgacgataa gtgataa                              1237


<210>  654
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 scFv

<400>  654
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  655
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2 scFv

<400>  655

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  656
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  656
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  657
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  657

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  658
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB domain

<400>  658
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  659
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB domain

<400>  659

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  660
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zeta domain

<400>  660
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  661
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta domain

<400>  661

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  662

<400>  662
000

<210>  663

<400>  663
000

<210>  664

<400>  664
000

<210>  665

<400>  665
000

<210>  666

<400>  666
000

<210>  667

<400>  667
000

<210>  668

<400>  668
000

<210>  669

<400>  669
000

<210>  670

<400>  670
000

<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678

<400>  678
000

<210>  679

<400>  679
000

<210>  680

<400>  680
000

<210>  681

<400>  681
000

<210>  682

<400>  682
000

<210>  683

<400>  683
000

<210>  684

<400>  684
000

<210>  685

<400>  685
000

<210>  686

<400>  686
000

<210>  687

<400>  687
000

<210>  688

<400>  688
000

<210>  689

<400>  689
000

<210>  690

<400>  690
000

<210>  691

<400>  691
000

<210>  692

<400>  692
000

<210>  693

<400>  693
000

<210>  694

<400>  694
000

<210>  695

<400>  695
000

<210>  696

<400>  696
000

<210>  697

<400>  697
000

<210>  698

<400>  698
000

<210>  699

<400>  699
000

<210>  700

<400>  700
000

<210>  701

<400>  701
000

<210>  702

<400>  702
000

<210>  703

<400>  703
000

<210>  704

<400>  704
000

<210>  705

<400>  705
000

<210>  706

<400>  706
000

<210>  707

<400>  707
000

<210>  708

<400>  708
000

<210>  709

<400>  709
000

<210>  710

<400>  710
000

<210>  711

<400>  711
000

<210>  712

<400>  712
000

<210>  713

<400>  713
000

<210>  714

<400>  714
000

<210>  715

<400>  715
000

<210>  716

<400>  716
000

<210>  717

<400>  717
000

<210>  718
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/41BB/CD3z #44 - NCD8lshuMNC2scFvCD8ecd fragment 
       CD8 transmembrane 41BB CD3zetaC

<400>  718
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct gataa                     1485


<210>  719
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CART C2 CD8/CD8/41BB/CD3z #44 - NCD8lshuMNC2scFvCD8ecd fragment 
       CD8 transmembrane 41BB CD3zetaC

<400>  719

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  720

<400>  720
000

<210>  721

<400>  721
000

<210>  722

<400>  722
000

<210>  723

<400>  723
000

<210>  724

<400>  724
000

<210>  725

<400>  725
000

<210>  726

<400>  726
000

<210>  727

<400>  727
000

<210>  728

<400>  728
000

<210>  729

<400>  729
000

<210>  730

<400>  730
000

<210>  731

<400>  731
000

<210>  732

<400>  732
000

<210>  733

<400>  733
000

<210>  734

<400>  734
000

<210>  735

<400>  735
000

<210>  736

<400>  736
000

<210>  737

<400>  737
000

<210>  738

<400>  738
000

<210>  739

<400>  739
000

<210>  740

<400>  740
000

<210>  741

<400>  741
000

<210>  742

<400>  742
000

<210>  743

<400>  743
000

<210>  744

<400>  744
000

<210>  745

<400>  745
000

<210>  746

<400>  746
000

<210>  747

<400>  747
000

<210>  748

<400>  748
000

<210>  749

<400>  749
000

<210>  750

<400>  750
000

<210>  751

<400>  751
000

<210>  752

<400>  752
000

<210>  753

<400>  753
000

<210>  754

<400>  754
000

<210>  755

<400>  755
000

<210>  756

<400>  756
000

<210>  757

<400>  757
000

<210>  758

<400>  758
000

<210>  759

<400>  759
000

<210>  760

<400>  760
000

<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774
<211>  3829
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1P2MMP9

<400>  774
caggcctggg gacactcgcg gcgggaagat ttggagggga ggggaggggg aggggcgtgg       60

gggcgcggcc tcgctggagt ccccctgacc ccccgacccc cgcccaccgg cctgggcgtc      120

ctcccgcggc ccctcctccc ctcccggcgc ccggtgctct ggggcgcgtg ccacgcctgg      180

ctcggcgccg taggggcccc cgcaggtaga gacccctgga aatggcctcg acgccgcagg      240

agcgaggcgg ccaccacccc gctaatccgg gcacgtctct ccaggccgag gcctgcggtg      300

gaaaagccgg ggttccattt gtgctgagtc ggggcggccg aatggagcca ggcctcggga      360

cgcgggacgg acgggctctg gccgcgcacc ttcgcgggct ctgcagcgcc cgaccgcctc      420

ccccggcagg gaggaggcgc ttgtgggggg cacccacggg gcacagtgat ccctgggggt      480

ctgcggacct cctgggcccc gcagcagaca cgagtttagc ctttgggttt agtttaaatc      540

acataagggt gtcgtgcaat cgatttatgg tttctacaca ccagacactt taacctccaa      600

ccccccccat ccaaagccaa caagaaaatg cggtgccgtg ttggcagctg agctgcgccc      660

gaagagacgc agggagacgt aagagaggaa agtgtgagtg gccggggggc ctccccccgt      720

cagaagtcgc gcagtcgcgc ccataaaacg ccccctccgg gcggctaggg caggtgagcg      780

cgtccccggg cctccccacg ccggcccctg ccacaggccg tctaggtcga gcagatattt      840

acagaataaa aatgacaata actcgacgtc ccgggacggc cacgcaatct gttagtaatt      900

tagcgggatg ggaatttcct ttctagggcc tgccagtgaa gcgcttttcc aaatttccac      960

agcgggggaa gcctgcgatt ttacataatg acttcagcat gccgggcttt ctcgacaccc     1020

ctccccggcc cccggccccc gccccccgcc ccttttccag cagggccggg ctccctccgg     1080

acacccgcgt ggactcaggc gtcccgtctg gcccgttcgc ccccgtttcc cccgccagcc     1140

ccagcgcccc cctgcccggc ccccggattc cccgttcccg cccctacgcc cccatcccct     1200

ccccgtgcgc ccctccccgt gcgcccccct ccccgtgcgc cccccctccc cgtgcgcccc     1260

cctccccgtg cgccccccct ccccgggcgc ccccctcccc gggcgccccc cctccccgtg     1320

cgcccccccc tccccgtgcg ccccccctcc ccgtgcgcgc cccgcctctt gcgcccctgc     1380

ccccaggcga gcggctgccg cggcgcgggg aggggcgggc gctcggcgac tcgtccccgg     1440

ggccccgcgc gggcccgggc agcaggggcg tgatgtcacg gcagggaggg ggcgcgggag     1500

ccgccgggcc ggcggggagg cgggggaggt gttttccagc tttaaaaagg caggaggcag     1560

agcgcggccc tgcgtcagag cgagactcag aggctccgaa ctcgccggcg gagtcgccgc     1620

gccagatccc agcagcaggg cgcggaagct tctctcgaca ttcgtttcta gagccaccat     1680

gagcctctgg cagcccctgg tcctggtgct cctggtgctg ggctgctgct ttgctgcccc     1740

cagacagcgc cagtccaccc ttgtgctctt ccctggagac ctgagaacca atctcaccga     1800

caggcagctg gcagaggaat acctgtaccg ctatggttac actcgggtgg cagagatgcg     1860

tggagagtcg aaatctctgg ggcctgcgct gctgcttctc cagaagcaac tgtccctgcc     1920

cgagaccggt gagctggata gcgccacgct gaaggccatg cgaaccccac ggtgcggggt     1980

cccagacctg ggcagattcc aaacctttga gggcgacctc aagtggcacc accacaacat     2040

cacctattgg atccaaaact actcggaaga cttgccgcgg gcggtgattg acgacgcctt     2100

tgcccgcgcc ttcgcactgt ggagcgcggt gacgccgctc accttcactc gcgtgtacag     2160

ccgggacgca gacatcgtca tccagtttgg tgtcgcggag cacggagacg ggtatccctt     2220

cgacgggaag gacgggctcc tggcacacgc ctttcctcct ggccccggca ttcagggaga     2280

cgcccatttc gacgatgacg agttgtggtc cctgggcaag ggcgtcgtgg ttccaactcg     2340

gtttggaaac gcagatggcg cggcctgcca cttccccttc atcttcgagg gccgctccta     2400

ctctgcctgc accaccgacg gtcgctccga cggcttgccc tggtgcagta ccacggccaa     2460

ctacgacacc gacgaccggt ttggcttctg ccccagcgag agactctaca cccaggacgg     2520

caatgctgat gggaaaccct gccagtttcc attcatcttc caaggccaat cctactccgc     2580

ctgcaccacg gacggtcgct ccgacggcta ccgctggtgc gccaccaccg ccaactacga     2640

ccgggacaag ctcttcggct tctgcccgac ccgagctgac tcgacggtga tggggggcaa     2700

ctcggcgggg gagctgtgcg tcttcccctt cactttcctg ggtaaggagt actcgacctg     2760

taccagcgag ggccgcggag atgggcgcct ctggtgcgct accacctcga actttgacag     2820

cgacaagaag tggggcttct gcccggacca aggatacagt ttgttcctcg tggcggcgca     2880

tgagttcggc cacgcgctgg gcttagatca ttcctcagtg ccggaggcgc tcatgtaccc     2940

tatgtaccgc ttcactgagg ggcccccctt gcataaggac gacgtgaatg gcatccggca     3000

cctctatggt cctcgccctg aacctgagcc acggcctcca accaccacca caccgcagcc     3060

cacggctccc ccgacggtct gccccaccgg accccccact gtccacccct cagagcgccc     3120

cacagctggc cccacaggtc ccccctcagc tggccccaca ggtcccccca ctgctggccc     3180

ttctacggcc actactgtgc ctttgagtcc ggtggacgat gcctgcaacg tgaacatctt     3240

cgacgccatc gcggagattg ggaaccagct gtatttgttc aaggatggga agtactggcg     3300

attctctgag ggcaggggga gccggccgca gggccccttc cttatcgccg acaagtggcc     3360

cgcgctgccc cgcaagctgg actcggtctt tgaggagcgg ctctccaaga agcttttctt     3420

cttctctggg cgccaggtgt gggtgtacac aggcgcgtcg gtgctgggcc cgaggcgtct     3480

ggacaagctg ggcctgggag ccgacgtggc ccaggtgacc ggggccctcc ggagtggcag     3540

ggggaagatg ctgctgttca gcgggcggcg cctctggagg ttcgacgtga aggcgcagat     3600

ggtggatccc cggagcgcca gcgaggtgga ccggatgttc cccggggtgc ctttggacac     3660

gcacgacgtc ttccagtacc gagagaaagc ctatttctgc caggaccgct tctactggcg     3720

cgtgagttcc cggagtgagt tgaaccaggt ggaccaagtg ggctacgtga cctatgacat     3780

cctgcagtgc cctgaggacg attacaagga tgacgacgat aagtgataa                 3829


<210>  775
<211>  2794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1P2MMP9cat

<400>  775
caggcctggg gacactcgcg gcgggaagat ttggagggga ggggaggggg aggggcgtgg       60

gggcgcggcc tcgctggagt ccccctgacc ccccgacccc cgcccaccgg cctgggcgtc      120

ctcccgcggc ccctcctccc ctcccggcgc ccggtgctct ggggcgcgtg ccacgcctgg      180

ctcggcgccg taggggcccc cgcaggtaga gacccctgga aatggcctcg acgccgcagg      240

agcgaggcgg ccaccacccc gctaatccgg gcacgtctct ccaggccgag gcctgcggtg      300

gaaaagccgg ggttccattt gtgctgagtc ggggcggccg aatggagcca ggcctcggga      360

cgcgggacgg acgggctctg gccgcgcacc ttcgcgggct ctgcagcgcc cgaccgcctc      420

ccccggcagg gaggaggcgc ttgtgggggg cacccacggg gcacagtgat ccctgggggt      480

ctgcggacct cctgggcccc gcagcagaca cgagtttagc ctttgggttt agtttaaatc      540

acataagggt gtcgtgcaat cgatttatgg tttctacaca ccagacactt taacctccaa      600

ccccccccat ccaaagccaa caagaaaatg cggtgccgtg ttggcagctg agctgcgccc      660

gaagagacgc agggagacgt aagagaggaa agtgtgagtg gccggggggc ctccccccgt      720

cagaagtcgc gcagtcgcgc ccataaaacg ccccctccgg gcggctaggg caggtgagcg      780

cgtccccggg cctccccacg ccggcccctg ccacaggccg tctaggtcga gcagatattt      840

acagaataaa aatgacaata actcgacgtc ccgggacggc cacgcaatct gttagtaatt      900

tagcgggatg ggaatttcct ttctagggcc tgccagtgaa gcgcttttcc aaatttccac      960

agcgggggaa gcctgcgatt ttacataatg acttcagcat gccgggcttt ctcgacaccc     1020

ctccccggcc cccggccccc gccccccgcc ccttttccag cagggccggg ctccctccgg     1080

acacccgcgt ggactcaggc gtcccgtctg gcccgttcgc ccccgtttcc cccgccagcc     1140

ccagcgcccc cctgcccggc ccccggattc cccgttcccg cccctacgcc cccatcccct     1200

ccccgtgcgc ccctccccgt gcgcccccct ccccgtgcgc cccccctccc cgtgcgcccc     1260

cctccccgtg cgccccccct ccccgggcgc ccccctcccc gggcgccccc cctccccgtg     1320

cgcccccccc tccccgtgcg ccccccctcc ccgtgcgcgc cccgcctctt gcgcccctgc     1380

ccccaggcga gcggctgccg cggcgcgggg aggggcgggc gctcggcgac tcgtccccgg     1440

ggccccgcgc gggcccgggc agcaggggcg tgatgtcacg gcagggaggg ggcgcgggag     1500

ccgccgggcc ggcggggagg cgggggaggt gttttccagc tttaaaaagg caggaggcag     1560

agcgcggccc tgcgtcagag cgagactcag aggctccgaa ctcgccggcg gagtcgccgc     1620

gccagatccc agcagcaggg cgcggaagct tctctcgaca ttcgtttcta gagccaccat     1680

gagcctctgg cagcccctgg tcctggtgct cctggtgctg ggctgctgct ttgctttcca     1740

aacctttgag ggcgacctca agtggcacca ccacaacatc acctattgga tccaaaacta     1800

ctcggaagac ttgccgcggg cggtgattga cgacgccttt gcccgcgcct tcgcactgtg     1860

gagcgcggtg acgccgctca ccttcactcg cgtgtacagc cgggacgcag acatcgtcat     1920

ccagtttggt gtcgcggagc acggagacgg gtatcccttc gacgggaagg acgggctcct     1980

ggcacacgcc tttcctcctg gccccggcat tcagggagac gcccatttcg acgatgacga     2040

gttgtggtcc ctgggcaagg gcgtcgtggt tccaactcgg tttggaaacg cagatggcgc     2100

ggcctgccac ttccccttca tcttcgaggg ccgctcctac tctgcctgca ccaccgacgg     2160

tcgctccgac ggcttgccct ggtgcagtac cacggccaac tacgacaccg acgaccggtt     2220

tggcttctgc cccagcgaga gactctacac ccaggacggc aatgctgatg ggaaaccctg     2280

ccagtttcca ttcatcttcc aaggccaatc ctactccgcc tgcaccacgg acggtcgctc     2340

cgacggctac cgctggtgcg ccaccaccgc caactacgac cgggacaagc tcttcggctt     2400

ctgcccgacc cgagctgact cgacggtgat ggggggcaac tcggcggggg agctgtgcgt     2460

cttccccttc actttcctgg gtaaggagta ctcgacctgt accagcgagg gccgcggaga     2520

tgggcgcctc tggtgcgcta ccacctcgaa ctttgacagc gacaagaagt ggggcttctg     2580

cccggaccaa ggatacagtt tgttcctcgt ggcggcgcat gagttcggcc acgcgctggg     2640

cttagatcat tcctcagtgc cggaggcgct catgtaccct atgtaccgct tcactgaggg     2700

gccccccttg cataaggacg acgtgaatgg catccggcac ctctatggtc ctcgccctga     2760

acctgattac aaggatgacg acgataagtg ataa                                 2794


<210>  776
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element 2

<400>  776
aagaggaaaa tttgtttcat acagaaggcg tt                                     32


<210>  777
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response element 2 repeats

<400>  777
aagaggaaaa tttgtttcat acagaaggcg ttaagaggaa aatttgtttc atacagaagg       60

cgttaagagg aaaatttgtt tcatacagaa ggcgttaaga ggaaaatttg tttcatacag      120

aaggcgtt                                                               128


<210>  778
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV minimal promoter 2

<400>  778
taggcgtgta cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc       60

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagc        118


<210>  779
<211>  2430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATRE2mCMV2MMP9

<400>  779
aagaggaaaa tttgtttcat acagaaggcg ttaagaggaa aatttgtttc atacagaagg       60

cgttaagagg aaaatttgtt tcatacagaa ggcgttaaga ggaaaatttg tttcatacag      120

aaggcgttac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg      180

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg      240

gaccgatcca gcctctcgac attcgtttct agagccacca tgagcctctg gcagcccctg      300

gtcctggtgc tcctggtgct gggctgctgc tttgctgccc ccagacagcg ccagtccacc      360

cttgtgctct tccctggaga cctgagaacc aatctcaccg acaggcagct ggcagaggaa      420

tacctgtacc gctatggtta cactcgggtg gcagagatgc gtggagagtc gaaatctctg      480

gggcctgcgc tgctgcttct ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat      540

agcgccacgc tgaaggccat gcgaacccca cggtgcgggg tcccagacct gggcagattc      600

caaacctttg agggcgacct caagtggcac caccacaaca tcacctattg gatccaaaac      660

tactcggaag acttgccgcg ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg      720

tggagcgcgg tgacgccgct caccttcact cgcgtgtaca gccgggacgc agacatcgtc      780

atccagtttg gtgtcgcgga gcacggagac gggtatccct tcgacgggaa ggacgggctc      840

ctggcacacg cctttcctcc tggccccggc attcagggag acgcccattt cgacgatgac      900

gagttgtggt ccctgggcaa gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc      960

gcggcctgcc acttcccctt catcttcgag ggccgctcct actctgcctg caccaccgac     1020

ggtcgctccg acggcttgcc ctggtgcagt accacggcca actacgacac cgacgaccgg     1080

tttggcttct gccccagcga gagactctac acccaggacg gcaatgctga tgggaaaccc     1140

tgccagtttc cattcatctt ccaaggccaa tcctactccg cctgcaccac ggacggtcgc     1200

tccgacggct accgctggtg cgccaccacc gccaactacg accgggacaa gctcttcggc     1260

ttctgcccga cccgagctga ctcgacggtg atggggggca actcggcggg ggagctgtgc     1320

gtcttcccct tcactttcct gggtaaggag tactcgacct gtaccagcga gggccgcgga     1380

gatgggcgcc tctggtgcgc taccacctcg aactttgaca gcgacaagaa gtggggcttc     1440

tgcccggacc aaggatacag tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg     1500

ggcttagatc attcctcagt gccggaggcg ctcatgtacc ctatgtaccg cttcactgag     1560

gggcccccct tgcataagga cgacgtgaat ggcatccggc acctctatgg tcctcgccct     1620

gaacctgagc cacggcctcc aaccaccacc acaccgcagc ccacggctcc cccgacggtc     1680

tgccccaccg gaccccccac tgtccacccc tcagagcgcc ccacagctgg ccccacaggt     1740

cccccctcag ctggccccac aggtcccccc actgctggcc cttctacggc cactactgtg     1800

cctttgagtc cggtggacga tgcctgcaac gtgaacatct tcgacgccat cgcggagatt     1860

gggaaccagc tgtatttgtt caaggatggg aagtactggc gattctctga gggcaggggg     1920

agccggccgc agggcccctt ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg     1980

gactcggtct ttgaggagcg gctctccaag aagcttttct tcttctctgg gcgccaggtg     2040

tgggtgtaca caggcgcgtc ggtgctgggc ccgaggcgtc tggacaagct gggcctggga     2100

gccgacgtgg cccaggtgac cggggccctc cggagtggca gggggaagat gctgctgttc     2160

agcgggcggc gcctctggag gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc     2220

agcgaggtgg accggatgtt ccccggggtg cctttggaca cgcacgacgt cttccagtac     2280

cgagagaaag cctatttctg ccaggaccgc ttctactggc gcgtgagttc ccggagtgag     2340

ttgaaccagg tggaccaagt gggctacgtg acctatgaca tcctgcagtg ccctgaggac     2400

gattacaagg atgacgacga taagtgataa                                      2430


<210>  780
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATRE2mCMV2MMP9cat

<400>  780
aagaggaaaa tttgtttcat acagaaggcg ttaagaggaa aatttgtttc atacagaagg       60

cgttaagagg aaaatttgtt tcatacagaa ggcgttaaga ggaaaatttg tttcatacag      120

aaggcgttac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg      180

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg      240

gaccgatcca gcctcgagct ctcgacattc gtttctagag ccaccatgag cctctggcag      300

cccctggtcc tggtgctcct ggtgctgggc tgctgctttg ctttccaaac ctttgagggc      360

gacctcaagt ggcaccacca caacatcacc tattggatcc aaaactactc ggaagacttg      420

ccgcgggcgg tgattgacga cgcctttgcc cgcgccttcg cactgtggag cgcggtgacg      480

ccgctcacct tcactcgcgt gtacagccgg gacgcagaca tcgtcatcca gtttggtgtc      540

gcggagcacg gagacgggta tcccttcgac gggaaggacg ggctcctggc acacgccttt      600

cctcctggcc ccggcattca gggagacgcc catttcgacg atgacgagtt gtggtccctg      660

ggcaagggcg tcgtggttcc aactcggttt ggaaacgcag atggcgcggc ctgccacttc      720

cccttcatct tcgagggccg ctcctactct gcctgcacca ccgacggtcg ctccgacggc      780

ttgccctggt gcagtaccac ggccaactac gacaccgacg accggtttgg cttctgcccc      840

agcgagagac tctacaccca ggacggcaat gctgatggga aaccctgcca gtttccattc      900

atcttccaag gccaatccta ctccgcctgc accacggacg gtcgctccga cggctaccgc      960

tggtgcgcca ccaccgccaa ctacgaccgg gacaagctct tcggcttctg cccgacccga     1020

gctgactcga cggtgatggg gggcaactcg gcgggggagc tgtgcgtctt ccccttcact     1080

ttcctgggta aggagtactc gacctgtacc agcgagggcc gcggagatgg gcgcctctgg     1140

tgcgctacca cctcgaactt tgacagcgac aagaagtggg gcttctgccc ggaccaagga     1200

tacagtttgt tcctcgtggc ggcgcatgag ttcggccacg cgctgggctt agatcattcc     1260

tcagtgccgg aggcgctcat gtaccctatg taccgcttca ctgaggggcc ccccttgcat     1320

aaggacgacg tgaatggcat ccggcacctc tatggtcctc gccctgaacc tgattacaag     1380

gatgacgacg ataagtgata a                                               1401


<210>  781
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter fragment (P1)

<400>  781
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagaggctcc gaactcgccg gcggagtcgc cgcgccagat     2220

cccagcagca gggcgcgg                                                   2238


<210>  782
<211>  2186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter fragment (P2)

<400>  782
aggcaggagg aagaggaaag gggcgcaggg cgctcgggga gcagagccgg gggcccgcgg       60

tggccgcaga ggccgggccg gggcgcagag gccgggcgag ctggccgcgc tctgggccgc      120

cgcctccgga actccctgcg cctggcgcgc ggccaccgtg gtcccggcaa cggcattaaa      180

cagagggaaa cagacccggg attccgtcac ccgggcgggg ggataaggac ggctttgaga      240

gcagacagga aaagggagct tttctgcatg gggtgaaaaa attatttatt gaaggaggag      300

gaggcggcag cggaggaagg ggaggggcgg gaggaggagg aagagccggc cgcccccgcc      360

ccggccccgg ctcctcagga gccaagggca gcctcgccag gtcggtcccg ggctcgagga      420

ccgcggctgg ggtcgagggg ctcagtctcc cacgtgaccg gctgggcgcg ccccgccaga      480

cccggcctcg ggattccctc ctcccggcga gtctccgccc gccccgtcct ggaggtgggg      540

agaaggaggg cggggcgggg gggacggaaa ctctccccgc caaatcctgg ccccaggcct      600

ggggacactc gcggcgggaa gatttggagg ggaggggagg gggaggggcg tgggggcgcg      660

gcctcgctgg agtccccctg accccccgac ccccgcccac cggcctgggc gtcctcccgc      720

ggcccctcct cccctcccgg cgcccggtgc tctggggcgc gtgccacgcc tggctcggcg      780

ccgtaggggc ccccgcaggt agagacccct ggaaatggcc tcgacgccgc aggagcgagg      840

cggccaccac cccgctaatc cgggcacgtc tctccaggcc gaggcctgcg gtggaaaagc      900

cggggttcca tttgtgctga gtcggggcgg ccgaatggag ccaggcctcg ggacgcggga      960

cggacgggct ctggccgcgc accttcgcgg gctctgcagc gcccgaccgc ctcccccggc     1020

agggaggagg cgcttgtggg gggcacccac ggggcacagt gatccctggg ggtctgcgga     1080

cctcctgggc cccgcagcag acacgagttt agcctttggg tttagtttaa atcacataag     1140

ggtgtcgtgc aatcgattta tggtttctac acaccagaca ctttaacctc caaccccccc     1200

catccaagcc aacaagaaaa tgcggtgccg tgttggcagc tgagctgcgc ccgaagagac     1260

gcagggagac gtaagagagg aaagtgtgag tggccggggg gcctcccccc gtcagaagtc     1320

gcgcagtcgc gcccataaaa cgccccctcc gggcggctag ggcaggtgag cgcgtccccg     1380

ggcctcccca cgccggcccc tgccacagag ccgtctaggt cgagcagata tttacagaat     1440

aaaaatgaca ataactcgac gtcccgggac ggccacgcaa tctgttagta atttagcggg     1500

atgggaattt cctttctagg gcctgccagt gaagcgcttt tccaaatttc cacagcgggg     1560

gaagcctgcg attttacata atgacttcag catgccgggc tttctcgaca cccctccccg     1620

gcccccggcc cccgcccccc gccccttttc cagcagggcc gggctccctc cggacacccg     1680

cgtggactca ggcgtcccgt ctggcccgtt cgcccccgtt tcccccgcca gccccagcgc     1740

ccccctgccc ggcccccgga ttccccgttc ccgcccctac gcccccatcc cctccccgtg     1800

cgcccctccc cgtgcgcccc cctccccgtg cgccccccct ccccgtgcgc ccccctcccc     1860

gtgcgccccc cctccccggg cgcccccctc cccgggcgcc ccccctcccc gtgcgccccc     1920

ccctccccgt gcgccccccc tccccgtgcg cgccccgcct cttgcgcccc tgcccccagg     1980

cgagcggctg ccgcggcgcg gggaggggcg ggcgctcggc gactcgtccc cggggccccg     2040

cgcgggcccg ggcagcaggg gcgtgatgtc acggcaggga gggggcgcgg gagccgccgg     2100

gccggcgggg aggcggggga ggtgttttcc agctttaaaa aggcaggagg cagagcgcgg     2160

ccctgcgtca gagcgagact cagagg                                          2186


<210>  783
<211>  1645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 Promoter fragment (P3)

<400>  783
caggcctggg gacactcgcg gcgggaagat ttggagggga ggggaggggg aggggcgtgg       60

gggcgcggcc tcgctggagt ccccctgacc ccccgacccc cgcccaccgg cctgggcgtc      120

ctcccgcggc ccctcctccc ctcccggcgc ccggtgctct ggggcgcgtg ccacgcctgg      180

ctcggcgccg taggggcccc cgcaggtaga gacccctgga aatggcctcg acgccgcagg      240

agcgaggcgg ccaccacccc gctaatccgg gcacgtctct ccaggccgag gcctgcggtg      300

gaaaagccgg ggttccattt gtgctgagtc ggggcggccg aatggagcca ggcctcggga      360

cgcgggacgg acgggctctg gccgcgcacc ttcgcgggct ctgcagcgcc cgaccgcctc      420

ccccggcagg gaggaggcgc ttgtgggggg cacccacggg gcacagtgat ccctgggggt      480

ctgcggacct cctgggcccc gcagcagaca cgagtttagc ctttgggttt agtttaaatc      540

acataagggt gtcgtgcaat cgatttatgg tttctacaca ccagacactt taacctccaa      600

ccccccccat ccaaagccaa caagaaaatg cggtgccgtg ttggcagctg agctgcgccc      660

gaagagacgc agggagacgt aagagaggaa agtgtgagtg gccggggggc ctccccccgt      720

cagaagtcgc gcagtcgcgc ccataaaacg ccccctccgg gcggctaggg caggtgagcg      780

cgtccccggg cctccccacg ccggcccctg ccacaggccg tctaggtcga gcagatattt      840

acagaataaa aatgacaata actcgacgtc ccgggacggc cacgcaatct gttagtaatt      900

tagcgggatg ggaatttcct ttctagggcc tgccagtgaa gcgcttttcc aaatttccac      960

agcgggggaa gcctgcgatt ttacataatg acttcagcat gccgggcttt ctcgacaccc     1020

ctccccggcc cccggccccc gccccccgcc ccttttccag cagggccggg ctccctccgg     1080

acacccgcgt ggactcaggc gtcccgtctg gcccgttcgc ccccgtttcc cccgccagcc     1140

ccagcgcccc cctgcccggc ccccggattc cccgttcccg cccctacgcc cccatcccct     1200

ccccgtgcgc ccctccccgt gcgcccccct ccccgtgcgc cccccctccc cgtgcgcccc     1260

cctccccgtg cgccccccct ccccgggcgc ccccctcccc gggcgccccc cctccccgtg     1320

cgcccccccc tccccgtgcg ccccccctcc ccgtgcgcgc cccgcctctt gcgcccctgc     1380

ccccaggcga gcggctgccg cggcgcgggg aggggcgggc gctcggcgac tcgtccccgg     1440

ggccccgcgc gggcccgggc agcaggggcg tgatgtcacg gcagggaggg ggcgcgggag     1500

ccgccgggcc ggcggggagg cgggggaggt gttttccagc tttaaaaagg caggaggcag     1560

agcgcggccc tgcgtcagag cgagactcag aggctccgaa ctcgccggcg gagtcgccgc     1620

gccagatccc agcagcaggg cgcgg                                           1645


<210>  784
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNFATMMP9cat1 gBLOCK sequence

<400>  784
aagaggaaaa tttgtttcat acagaaggcg ttactagtta ggcgtgtacg gtgggaggcc       60

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt      120

tttgacctcc atagaagaca ccgggaccga tccagcctct cgacattcgt ttctagagcc      180

accatgagcc tctggcagcc cctggtcctg gtgctcctgg tgctgggctg ctgctttgct      240

ttccaaacct ttgagggcga cctcaagtgg caccaccaca acatcaccta ttggatccaa      300

aactactcgg aagacttgcc gcgggcggtg attgacgacg cctttgcccg cgccttcgca      360

ctgtggagcg cggtgacgcc gctcaccttc actcgcgtgt acagccggga cgcagacatc      420

gtcatccagt ttggtgtcgc ggagcacgga gacgggtatc ccttcgacgg gaaggacggg      480

ctcctggcac acgcctttcc tcctggcccc ggcattcagg gagacgccca tttcgacgat      540

gacgagttgt ggtccctggg caagggcgtc gtggttccaa ctcggtttgg aaacgcagat      600

ggcgcggcct gccacttccc cttcatcttc gagggccgct cctactctgc ctgcaccacc      660

gacggtcgct ccgacggctt gccctggtgc agtaccacgg ccaactacga caccgacgac      720

cggtttggct tctgccccag cgagagactc tacacccagg acggcaatgc tgatgggaaa      780

ccctgccagt ttccattcat cttccaaggc caatcctact ccgcctgcac cacggacggt      840

cgctccgacg gctaccgctg gtgcgccacc accgccaact acgaccggga caagctcttc      900

ggcttctgcc cgacccgagc tgactcg                                          927


<210>  785
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  785

Asp Tyr Tyr Gly Ser Asn Pro Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  786
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 4 (FW4) sequence

<400>  786

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801

<400>  801
000

<210>  802

<400>  802
000

<210>  803

<400>  803
000

<210>  804
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NFAT consensus sequence

<400>  804

Ala Thr Gly Gly Ala Ala Ala Ala Asn Ala Thr Cys Asn 
1               5                   10              


<210>  805
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Current NFAT RE (Form System Biosciences. The sequence is from 
       the mouse IL2 promoter.)

<400>  805
aagaggaaaa tttgtttcat acagaaggcg tt                                     32


<210>  806
<211>  812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse IL2 Promoter (highlighted in green the NFAT RE used, 
       highlighted in yellow is the start codon)

<400>  806
aactagagac atataaaata acaccaacat ccttagatac aacccttcct gagaatttat       60

tggacatcat actcttttta aaaagcataa taaacatcaa gacacttaca caaaatatgt      120

taaattaaat ttaaaacaac aacgacaaaa tagtacctca agctcaacaa gcattttagg      180

tgtccttagc ttactatttc tctggctaac tgtatgaagc catctatcac cctgtgtgca      240

attagctcat tgtgtagata agaaggtaaa accatcttga aacaggaaac caatatcctt      300

cctgtctaat caacaaatct aaaagattta ttcttttcat ctatctcctc ttgcgtttgt      360

ccaccacaac aggctgctta caggttcagg atggttttga caaagagaac attttcatga      420

gttacttttg tgtctccacc ccaaagagga aaatttgttt catacagaag gcgttcattg      480

tatgaattaa aactgccacc taagtgtggg ctaacccgac caagagggat ttcacctaaa      540

tccattcagt cagtgtatgg gggtttaaag aaattccaga gagtcatcag aagaggaaaa      600

acaaaaggta atgctttctg ccacacaggt agactctttg aaaatatgtg taatatgtaa      660

aacatcgtga cacccccata ttatttttcc agcattaaca gtataaattg cctcccatgc      720

tgaagagctg cctatcaccc ttgctaatca ctcctcacag tgacctcaag tcctgcaggc      780

atgtacagca tgcagctcgc atcctgtgtc ac                                    812


<210>  807
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT RE (Form PRomega. The sequence is from the humane IL2 
       promoter.)

<400>  807
ggaggaaaaa ctgtttcata cagaaggcgt                                        30


<210>  808
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from ET1 promoter

<400>  808
tccagggaaa atcggagtag aacaagaggg atg                                    33


<210>  809
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from ET1 promoter

<400>  809
actgttggaa aacgtaaaca cgttattaaa cggt                                   34


<210>  810
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human CD3?

<400>  810
tccttaacgg aaaaacaaaa                                                   20


<210>  811
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human CD3?

<400>  811
aaaggaaaaa gtatatgttc                                                   20


<210>  812
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human IL3 promoter

<400>  812
atgccatgga aagggtg                                                      17


<210>  813
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human GPC6

<400>  813
aaggggaaat gttgagtcta ga                                                22


<210>  814
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Possible NFAT RE from human growth hormonereleasing hormone

<400>  814
aacttggaaa agcatag                                                      17


<210>  815
<211>  5320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 promoter large

<400>  815
ttatgccgtc tagaggagac atactttcta ctcaaagcta cacacataga ctacaacgat       60

gggaaaagac gacacaccaa cagcgacttc aggaaagctg gagtggctgc taatgttaga      120

caaaataggc tttttaaaaa aggttttatt aaagaggaat gtttcgtaat gataaaagca      180

ctaatctgtg agaaagatac aacaatgata aacatacgtg cagctaataa gagagctcca      240

aaatctatga agcaaaaact cacagaatga ggggagaagc agttctacaa cagagaatgg      300

ggacttcgat actccacttt caataatgga tacaacaacc aggcagataa caaggcaaca      360

gaaggcctga acaacagtat aaaccaatta gacctaccag atatctatag ctagcacact      420

ccacccaacg acagcagaat acacattctt ctcaagcgca caagtaacat cctccaggat      480

gggccatgtt ctaggccatc aaacaaactc aggtggtttg aggccagagg cctctctttt      540

aaccaccaca ctagggcctt cggaggaggc aagcagagag ttgtcaaaga ggccctcagg      600

actgggtgca gtggctcatg actgtaatcc cagcacttta gaaggctgag gcacaaggat      660

cttttgagct caggagttca agaaatgagc acttatccac tgggcgcggt ggctcacgcc      720

agtaatccag cactttggga ggcttaggcg ggcggatcaa gaggtcagaa gctcaagacc      780

agcctgacca acatggtgaa accccgtctc tactaaaagt acaaaaatta gccgggcgtg      840

gtggcgcaca cctgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgaacc      900

cgggaggtgg aggttgcagt gagtggagat cacaccattg caccccagcc tgggcaacag      960

agcgagactc cgtctcaaaa aaaaaaaaaa aaaaaaagaa agaaagaaaa agaaaaaaaa     1020

agtgagcatg tattttgcca gagtctggag attagaatta aattagcaaa ccagaattat     1080

agaaaaagct atttactttt aagtaaacag ctgagatttt tttttttaag tcagtgtgaa     1140

tgaagctcac agccatggtt ggagctgaga aagaaggatt tccctttagt tatgcacctg     1200

tgtcagcacc ttctgacttt ccttctaaag tctggggtgt tcctgaggat ccgtaagttt     1260

ggggttcagg gtttctacag catgctgtta cttgtgaaac atctctttaa ccatgtccca     1320

gagttgccca ggagtttaag accagcctga gcaacatagc aagacctcat ctcaacaaca     1380

acaaaaatta gaaataaatt agccaggtgt ggtgacatgt gcctgtagtc ccagctactc     1440

agaaggctga ggcatgagga tcacttgggc ccaggaagtt ggggctgcag ggagccctgt     1500

tcatgccgct gcactccagc ctgcaagaca gagcagaaaa aaagaatcag gatcctgggc     1560

agagggagga gaggggaccg gggtccagca agcacttggg gattgactga atggcgttgg     1620

ggagagatga ctccaaagtc ctggagtggg tgagaatgac tgcgagtggc ttttaggtgg     1680

ggaggttcct gcctggccac tccgggaggg gacgtggggc tgaagggtat caggtgccgt     1740

gctgagcagt ttggccttga tcctaatgcc ctggacacac gtctagggta ggaaagttga     1800

ctgatccatt ggtgatctga gtttttagac atggtggtag tccatgaggt gggtgttcat     1860

gctaagagtt tagacaggga aacctatgaa gcccttagca accctccagg gaaggggcgt     1920

ggttaaagag atgtttcata agtaacagca tggtatagaa actctgaacc ccaaatgtat     1980

gggtcctcag gaacacccca gactttagaa ggaaagtcag aaggtgctga cacgggtgta     2040

taactaaagg gaaatccttc tttctcagct ccaaccatgg ctgtgaggtt cattcacact     2100

gacttaaaaa aaaaaatctc agtttactta aaagtaaata gctttttcta taattctggt     2160

ttgctaattt aatcctagtc tccagaccct ggctaaataa atgcccattt ctccagatgg     2220

tctcaagagt ctctggacat cgtgggggcc cttccctgtt ggttggaagg tgcctcagga     2280

agaagggggt ggattctgag ttgagtcaaa acctcaaaga cccctgatgg gaaaagctct     2340

caagtgacca ccgctgtggg ccagaatgca aaactgcagg aacagaacat tcgcaggaac     2400

agaacacagt cgtattaagt gattttcccg agcaggaagt ggcatctggc ctgcggttca     2460

gtagggggag gaaagggtgg gcgcacctgc ccctggctgg cgcacctgcc aggtagcccc     2520

acgcggcacc gcgtgtgccg agcgcccctg aggatggaaa gccccacgcg gggcaggtgg     2580

cacccaccct ccgaagacgg gacgggatgg agcgttgagc ttcggggcag ctccggcccg     2640

gcccgcgctg gagacgcccg catctgccag gatggcgtct catagccctg gtgctcacac     2700

atgacgccag gaagccccag caacagtgac cgcccaggct ctagaaaata ttggacgggg     2760

tggatgaaca cccaagtgcg ctccaggaga agggatttgg caccccaagg ggcttttaaa     2820

acggtaagct tctaggggtg tctttgcccc caataatcca tagaaacaac agtcatctaa     2880

aaatagtctt gttttctgtc ctaagctcct tttaactttg ttagtcatca ccaatcctaa     2940

aataaaaccc gtgtaacgtc tcccctagta gcggctataa acaaacctac gaggaggcag     3000

gaggaagagg aaaggggcgc agggcgctcg gggagcagag ccgggggccc gcggtggccg     3060

cagaggccgg gccggggcgc agaggccggg cgagctggcc gcgctctggg ccgccgcctc     3120

cggaactccc tgcgcctggc gcgcggccac cgtggtcccg gcaacggcat taaacagagg     3180

gaaacagacc cgggattccg tcacccgggc ggggggataa ggacggcttt gagagcagac     3240

aggaaaaggg agcttttctg catggggtga aaaaattatt tattgaagga ggaggaggcg     3300

gcagcggagg aaggggaggg gcgggaggag gaggaagagc cggccgcccc cgccccggcc     3360

ccggctcctc aggagccaag ggcagcctcg ccaggtcggt cccgggctcg aggaccgcgg     3420

ctggggtcga ggggctcagt ctcccacgtg accggctggg cgcgccccgc cagacccggc     3480

ctcgggattc cctcctcccg gcgagtctcc gcccgccccg tcctggaggt ggggagaagg     3540

agggcggggc gggggggacg gaaactctcc ccgccaaatc ctggccccag gcctggggac     3600

actcgcggcg ggaagatttg gaggggaggg gagggggagg ggcgtggggg cgcggcctcg     3660

ctggagtccc cctgaccccc cgacccccgc ccaccggcct gggcgtcctc ccgcggcccc     3720

tcctcccctc ccggcgcccg gtgctctggg gcgcgtgcca cgcctggctc ggcgccgtag     3780

gggcccccgc aggtagagac ccctggaaat ggcctcgacg ccgcaggagc gaggcggcca     3840

ccaccccgct aatccgggca cgtctctcca ggccgaggcc tgcggtggaa aagccggggt     3900

tccatttgtg ctgagtcggg gcggccgaat ggagccaggc ctcgggacgc gggacggacg     3960

ggctctggcc gcgcaccttc gcgggctctg cagcgcccga ccgcctcccc cggcagggag     4020

gaggcgcttg tggggggcac ccacggggca cagtgatccc tgggggtctg cggacctcct     4080

gggccccgca gcagacacga gtttagcctt tgggtttagt ttaaatcaca taagggtgtc     4140

gtgcaatcga tttatggttt ctacacacca gacactttaa cctccaaccc cccccatcca     4200

aagccaacaa gaaaatgcgg tgccgtgttg gcagctgagc tgcgcccgaa gagacgcagg     4260

gagacgtaag agaggaaagt gtgagtggcc ggggggcctc cccccgtcag aagtcgcgca     4320

gtcgcgccca taaaacgccc cctccgggcg gctagggcag gtgagcgcgt ccccgggcct     4380

ccccacgccg gcccctgcca caggccgtct aggtcgagca gatatttaca gaataaaaat     4440

gacaataact cgacgtcccg ggacggccac gcaatctgtt agtaatttag cgggatggga     4500

atttcctttc tagggcctgc cagtgaagcg cttttccaaa tttccacagc gggggaagcc     4560

tgcgatttta cataatgact tcagcatgcc gggctttctc gacacccctc cccggccccc     4620

ggcccccgcc ccccgcccct tttccagcag ggccgggctc cctccggaca cccgcgtgga     4680

ctcaggcgtc ccgtctggcc cgttcgcccc cgtttccccc gccagcccca gcgcccccct     4740

gcccggcccc cggattcccc gttcccgccc ctacgccccc atcccctccc cgtgcgcccc     4800

tccccgtgcg cccccctccc cgtgcgcccc ccctccccgt gcgcccccct ccccgtgcgc     4860

cccccctccc cgggcgcccc cctccccggg cgccccccct ccccgtgcgc ccccccctcc     4920

ccgtgcgccc cccctccccg tgcgcgcccc gcctcttgcg cccctgcccc caggcgagcg     4980

gctgccgcgg cgcggggagg ggcgggcgct cggcgactcg tccccggggc cccgcgcggg     5040

cccgggcagc aggggcgtga tgtcacggca gggagggggc gcgggagccg ccgggccggc     5100

ggggaggcgg gggaggtgtt ttccagcttt aaaaaggcag gaggcagagc gcggccctgc     5160

gtcagagcga gactcagagg ctccgaactc gccggcggag tcgccgcgcc agatcccagc     5220

agcagggcgc gggcaccggg gcgcgggcag ggctcggagc caccgcgcag gtcctagggc     5280

cgcggccggg ccccgccacg cgcgcacacg cccctcgatg                           5320


<210>  816
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc3 promoter sequence

<400>  816
gcagccaggc agggtgggcg cgcgtagggg gcggggccgg gcgcgcggca gggcgcgaga       60

gcgcacccgc ggcggcggtg gcggcgactg tgggggggcg gcggggaaca ttggctaagc      120

cgacagtgga ggcttaggca ccggtggcgg gcggctgcgg ttcctggtgc tgctcggcgc      180

gcggccagct ttcggaacgg aacgctcggc gtcgcgggcc ccgcccggaa agtttgccgt      240

ggagtcgcga cctcttggcc cgcgcggccc ggcatgaagc ggcgttgagg agctgctgcc      300

gccgcttgcc gctgccgccg ccgccgcctg aggaggagct gcagcaccct gggccacgcc      360

g                                                                      361


<210>  817
<211>  430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc2 promoter sequence 1

<400>  817
cagagagagg ctgcgttcag actggggcac tgccatcccc tccgcatcat ggggtctgtg       60

gaccaaggta actgactctc gatcccttcc agccttttcc gctcgctcct cccggccctt      120

tcctgctgct cccgtcccgg gcagcacttt cagctcccgg cagaggtcgg tgcgggaggc      180

ctggggaccc cgctcgccct cggcgcacag gtagcggggc ccgcggaggg gcgcccgcgc      240

cccggccagg gaagggacac ttgggaaggc gactttggac aactttacgc gggggcaggg      300

aagtgtccca ggccgggatt ccctaggcca gtctgtcggg aggattttcc tctccacggg      360

acaccgggag ggattctcgc tactaaccgc tggctgttta accgtttcag cactcggctt      420

ttgacagcaa                                                             430


<210>  818
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc2 promoter sequence 2

<400>  818
catcatgggg tctgtggacc aaggtaactg actctcgatc ccttccagcc ttttccgctc       60

gctc                                                                    64


<210>  819
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 response element consensus

<400>  819
cattttttcc at                                                           12


<210>  820
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFATc1 response element consensus

<400>  820
tttttcca                                                                 8


<210>  821
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT response elements contained within the Foxp3 enhancer region

<400>  821
acttgaaaat gagataaatg ttcacctatg ttggcttcta gtctctttta tggcttcatt       60

ttttccattt actatagagg ttaagagtgt gggtactgga gccagactgt ctgggacaa       119


<210>  822
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N+20

<400>  822

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            20                  25                  30          


Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser 
        35                  40                  45              


Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly 
    50                  55                  60                  


Ala 
65  


<210>  823
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N+20/C27

<400>  823

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe 
            20                  25                  30          


Asn Gln Tyr Lys Thr Glu 
        35              


<210>  824
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N+9/C9

<400>  824

Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp 
1               5                   10                  15      


Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr 
            20                  25                  30          


Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro 
        35                  40                  45  


<210>  825
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10

<400>  825

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val 
        35  


<210>  826
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NME7AB

<400>  826
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac caattgtacg tgctgtattg tcaaaccgca cgcagtgtca      480

gaaggcctgc tgggtaaaat tctgatggca atccgtgatg ctggctttga aatctcggcc      540

atgcagatgt tcaacatgga ccgcgttaac gtcgaagaat tctacgaagt ttacaaaggc      600

gtggttaccg aatatcacga tatggttacg gaaatgtact ccggtccgtg cgtcgcgatg      660

gaaattcagc aaaacaatgc caccaaaacg tttcgtgaat tctgtggtcc ggcagatccg      720

gaaatcgcac gtcatctgcg tccgggtacc ctgcgcgcaa tttttggtaa aacgaaaatc      780

cagaacgctg tgcactgtac cgatctgccg gaagacggtc tgctggaagt tcaatacttt      840

ttcaaaattc tggataatct cgagcaccac caccaccacc actga                      885


<210>  827
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7AB

<400>  827

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn Leu Glu 
        275                 280                 285             


His His His His His His 
    290                 


<210>  828
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7 x1

<400>  828
atgatgatgc tttcaaggaa agaagcattg gattttcatg tagatcacca gtcaagaccc       60

tttttcaatg agctgatcca gtttattaca actggtccta ttattgccat ggagatttta      120

agagatgatg ctatatgtga atggaaaaga ctgctgggac ctgcaaactc tggagtggca      180

cgcacagatg cttctgaaag cattagagcc ctctttggaa cagatggcat aagaaatgca      240

gcgcatggcc ctgattcttt tgcttctgcg gccagagaaa tggagttgtt ttttccttca      300

agtggaggtt gtgggccggc aaacactgct aaatttacta attgtacctg ttgcattgtt      360

aaaccccatg ctgtcagtga aggactgttg ggaaagatcc tgatggctat ccgagatgca      420

ggttttgaaa tctcagctat gcagatgttc aatatggatc gggttaatgt tgaggaattc      480

tatgaagttt ataaaggagt agtgaccgaa tatcatgaca tggtgacaga aatgtattct      540

ggcccttgtg tagcaatgga gattcaacag aataatgcta caaagacatt tcgagaattt      600

tgtggacctg ctgatcctga aattgcccgg catttacgcc ctggaactct cagagcaatc      660

tttggtaaaa ctaagatcca gaatgctgtt cactgtactg atctgccaga ggatggccta      720

ttagaggttc aatacttctt caagatcttg gataatctcg agcaccacca ccaccaccac      780

tga                                                                    783


<210>  829
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7 x1

<400>  829

Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
1               5                   10                  15      


Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
            20                  25                  30          


Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
        35                  40                  45              


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
    50                  55                  60                  


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala 
65                  70                  75                  80  


Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu 
                85                  90                  95      


Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe 
            100                 105                 110         


Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
        115                 120                 125             


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
    130                 135                 140                 


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
145                 150                 155                 160 


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
                165                 170                 175     


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
            180                 185                 190         


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
        195                 200                 205             


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
    210                 215                 220                 


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
225                 230                 235                 240 


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn Leu Glu His His 
                245                 250                 255     


His His His His 
            260 


<210>  830
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody 17H6 Heavy chain: DNA sequence - Signal sequence 
       FR1CDR1FR2CDR2FR3CDR3FR4

<400>  830
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgag       60

gtgaagctgg tggagtctgg aggaggcttg gtacagcctg ggggttctct gagactctcc      120

tgtgcaactt ctgggttcac cttcactgat tactacatga gctgggtccg ccagcctcca      180

agaaaggcac ttgagtggtt gggttttatt agaaacaaag ctaatggtta cacagcagag      240

tacagtgcgt ctgtgaaggg tcggttcacc atctccagag atgtttccca aaacctcctc      300

tatcttcaaa tgaacatcct gagagctgag gacagtgcca cttattactg tgcaaaagat      360

tactacggta gtaaccctgc ctggtttgct tactggggcc aagggactct ggtcactgtc      420

tctgca                                                                 426


<210>  831
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody 17H6 Heavy chain: Amino acid sequence - Signal 
       peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  831

Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Arg Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Ala Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ser 
                85                  90                  95      


Gln Asn Leu Leu Tyr Leu Gln Met Asn Ile Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Lys Asp Tyr Tyr Gly Ser Asn Pro Ala Trp 
        115                 120                 125             


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140         


<210>  832
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 1 (FW1) sequence

<400>  832
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact                                        90


<210>  833
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 1 (FW1) sequence

<400>  833

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr 
            20                  25                  30  


<210>  834
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  834
gattactaca tgagc                                                        15


<210>  835
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  835

Asp Tyr Tyr Met Ser 
1               5   


<210>  836
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 2 (FW2) sequence

<400>  836
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact                                        90


<210>  837
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 2 (FW2) sequence

<400>  837

Trp Val Arg Gln Pro Pro Arg Lys Ala Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  838
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  838
tttattagaa acaaagctaa tggttacaca gcagagtaca gtgcgtctgt gaagggt          57


<210>  839
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  839

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Ala Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  840
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 3 (FW3) sequence

<400>  840
cggttcacca tctccagaga tgtttcccaa aacctcctct atcttcaaat gaacatcctg       60

agagctgagg acagtgccac ttattactgt gcaaaa                                 96


<210>  841
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 3 (FW3) sequence

<400>  841

Arg Phe Thr Ile Ser Arg Asp Val Ser Gln Asn Leu Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ile Leu Arg Ala Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  842
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  842
gattactacg gtagtaaccc tgcctggttt gcttac                                 36


<210>  843
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 heavy chain variable framework 4 (FW4) sequence

<400>  843
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  844
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody 17H6 Light chain: DNA sequence - Signal sequence 
       FR1CDR1FR2CDR2FR3CDR3FR4

<400>  844
atgaagttgc ctgtgaggct gttggtgctg atgttctgga ttcctgcttc caacagtgat       60

attttgatga cccagactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag cattgtacat agtagtggaa acaccttttt agaatggtac      180

ctgcagaaac ctggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggatag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttcctttc      360

acgttcggct cggggacaaa gttggaaata aaa                                   393


<210>  845
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody 17H6 Light chain: Amino acid sequence - Signal 
       peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  845

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Asn Ser Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Ser Gly Asn Thr Phe Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ile Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  846
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 1 (FW1) sequence

<400>  846
gatattttga tgacccagac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  847
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 1 (FW1) sequence

<400>  847

Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  848
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  848
agatctagtc agagcattgt acatagtagt ggaaacacct ttttagaa                    48


<210>  849
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  849

Arg Ser Ser Gln Ser Ile Val His Ser Ser Gly Asn Thr Phe Leu Glu 
1               5                   10                  15      


<210>  850
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 2 (FW2) sequence

<400>  850
tggtacctgc agaaacctgg ccagtctcca aagctcctga tctac                       45


<210>  851
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 2 (FW2) sequence

<400>  851

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  852
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  852
aaagtttcca accgattttc t                                                 21


<210>  853
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  853

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  854
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 3 (FW3) sequence

<400>  854
ggggtcccag acaggttcag tggcagtgga tcagggatag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  855
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 3 (FW3) sequence

<400>  855

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ile Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  856
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  856
tttcaaggtt cacatgttcc tttcacg                                           27


<210>  857
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  857

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  858
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 4 (FW4) sequence

<400>  858
ttcggctcgg ggacaaagtt ggaaataaaa                                        30


<210>  859
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 17H6 light chain variable framework 4 (FW4) sequence

<400>  859

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  860
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 Heavy chain: DNA sequence - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  860
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggagagcc aacatatgtt      240

ggtgacttca agggacggtt tgccttctct ttggagacct ctgccagcac tgcctatttg      300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tttgtgttag aggtatccac      360

ggctacgtgg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210>  861
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 Heavy chain: Amino acid sequence - Signal 
       peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  861

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val 
65                  70                  75                  80  


Gly Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Val Arg Gly Ile His Gly Tyr Val Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135     


<210>  862
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 1 (FW1) 
       sequence

<400>  862
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca                                        90


<210>  863
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 1 (FW1) 
       sequence

<400>  863

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  864
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  864
aactatggaa tgaac                                                        15


<210>  865
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  865

Asn Tyr Gly Met Asn 
1               5   


<210>  866
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 2 (FW2) 
       sequence

<400>  866
tgggtgaagc aggctccagg aaagggttta aagtggatgg gc                          42


<210>  867
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 2 (FW2) 
       sequence

<400>  867

Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  868
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  868
tggataaaca cctacactgg agagccaaca tatgttggtg acttcaaggg a                51


<210>  869
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  869

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Val Gly Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  870
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 3 (FW3) 
       sequence

<400>  870
cggtttgcct tctctttgga gacctctgcc agcactgcct atttgcagat caacaacctc       60

aaaaatgagg acacggctac atatttttgt gttaga                                 96


<210>  871
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 3 (FW3) 
       sequence

<400>  871

Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg 
            20                  25                  30          


<210>  872
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  872
ggtatccacg gctacgtgga ctac                                              24


<210>  873
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  873

Gly Ile His Gly Tyr Val Asp Tyr 
1               5               


<210>  874
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 4 (FW4) 
       sequence

<400>  874
tggggccaag gcaccactct cacagtctcc tca                                    33


<210>  875
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable framework 4 (FW4) 
       sequence

<400>  875

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  876
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 Light chain: DNA sequence - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  876
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag cattgtacat agaaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tcttccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  877
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 Light chain: Amino acid sequence - Signal 
       peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  877

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Arg Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  878
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 1 (FW1) 
       sequence

<400>  878
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  879
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 1 (FW1) 
       sequence

<400>  879

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  880
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  880
agatctagtc agagcattgt acatagaaat ggaaacacct atttagaa                    48


<210>  881
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  881

Arg Ser Ser Gln Ser Ile Val His Arg Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  882
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 2 (FW2) 
       sequence

<400>  882
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  883
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 2 (FW2) 
       sequence

<400>  883

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  884
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  884
aaagtttcca accgattttc t                                                 21


<210>  885
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  885

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  886
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 3 (FW3) 
       sequence

<400>  886
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  887
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 3 (FW3) 
       sequence

<400>  887

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  888
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  888
tttcaaggtt cacatcttcc gtggacg                                           27


<210>  889
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  889

Phe Gln Gly Ser His Leu Pro Trp Thr 
1               5                   


<210>  890
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 4 (FW4) 
       sequence

<400>  890
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  891
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable framework 4 (FW4) 
       sequence

<400>  891

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  892
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody 3C5 Heavy chain: DNA sequence - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  892
atggcttggg tgtggacctt gctgttcctg atggcagctg cccaaagtgc ccaagcacag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caagatctcc      120

tgcaaggctt ctgggtatac cttcacaaac tatggaatga actgggtgaa gcaggctcca      180

ggaaagggtt taaagtggat gggctggata aacacctaca ctggaaagcc aacatatgct      240

gatgacttca agggacggtt tgccttctct ttggagacct ctgccagcac tgcctatttg      300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgcaag agggggacta      360

gatggttact acggctactg gggccaaggc accactctca cagtctcctc a               411


<210>  893
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3C5 Heavy chain: Amino acid sequence - Signal 
       peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  893

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Leu Asp Gly Tyr Tyr Gly Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135         


<210>  894
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 1 (FW1) 
       sequence

<400>  894
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca                                        90


<210>  895
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 1 (FW1) 
       sequence

<400>  895

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  896
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  896
aactatggaa tgaac                                                        15


<210>  897
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  897

Asn Tyr Gly Met Asn 
1               5   


<210>  898
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 2 (FW2) 
       sequence

<400>  898
tgggtgaagc aggctccagg aaagggttta aagtggatgg gc                          42


<210>  899
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 2 (FW2) 
       sequence

<400>  899

Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  900
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  900
tggataaaca cctacactgg aaagccaaca tatgctgatg acttcaaggg a                51


<210>  901
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  901

Trp Ile Asn Thr Tyr Thr Gly Lys Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  902
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 3 (FW3) 
       sequence

<400>  902
cggtttgcct tctctttgga gacctctgcc agcactgcct atttgcagat caacaacctc       60

aaaaatgagg acacggctac atatttctgt gcaaga                                 96


<210>  903
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 3 (FW3) 
       sequence

<400>  903

Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  904
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  904
gggggactag atggttacta cggctac                                           27


<210>  905
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  905

Gly Gly Leu Asp Gly Tyr Tyr Gly Tyr 
1               5                   


<210>  906
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 4 (FW4) 
       sequence

<400>  906
tggggccaag gcaccactct cacagtctcc tca                                    33


<210>  907
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 heavy chain variable framework 4 (FW4) 
       sequence

<400>  907

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  908
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody 3C5 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  908
atgagtcctg cccagttcct gtttctgcta gtgctctcga ttcaggaaac caacggtgat       60

gttgtgatgg ctcagacccc actcactttg tcggttacca ttggacaacc agcctccatc      120

tcttgcaaat caagtcagag cctcttacat agtaaaggaa agacatattt gaattggtta      180

ttacagaggc caggccagtc tccaaagctc ctaatctatc tggtgtctaa actggaatct      240

ggagtccctg acaggttcag tggcagtgga tcagggacag atttcacact gaaaatcagc      300

agagtggagg ctgaagattt gggagtttat tactgcttgc aaactacaca ttttccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  909
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 3C5 Light chain: Amino acid sequence (131 aa) - Signal 
       peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  909

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Ser Ile Gln Glu 
1               5                   10                  15      


Thr Asn Gly Asp Val Val Met Ala Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu His Ser Lys Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Leu Gln Thr Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  910
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 1 (FW1) 
       sequence

<400>  910
gatgttgtga tggctcagac cccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgc                                                               69


<210>  911
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 1 (FW1) 
       sequence

<400>  911

Asp Val Val Met Ala Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  912
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  912
aaatcaagtc agagcctctt acatagtaaa ggaaagacat atttgaat                    48


<210>  913
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  913

Lys Ser Ser Gln Ser Leu Leu His Ser Lys Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  914
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 2 (FW2) 
       sequence

<400>  914
tggttattac agaggccagg ccagtctcca aagctcctaa tctat                       45


<210>  915
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 2 (FW2) 
       sequence

<400>  915

Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  916
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  916
ctggtgtcta aactggaatc t                                                 21


<210>  917
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  917

Leu Val Ser Lys Leu Glu Ser 
1               5           


<210>  918
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 3 (FW3) 
       sequence

<400>  918
ggagtccctg acaggttcag tggcagtgga tcagggacag atttcacact gaaaatcagc       60

agagtggagg ctgaagattt gggagtttat tactgc                                 96


<210>  919
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 3 (FW3) 
       sequence

<400>  919

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  920
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  920
ttgcaaacta cacattttcc gtggacg                                           27


<210>  921
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  921

Leu Gln Thr Thr His Phe Pro Trp Thr 
1               5                   


<210>  922
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 4 (FW4) 
       sequence

<400>  922
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  923
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C5 light chain variable framework 4 (FW4) 
       sequence

<400>  923

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  924
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 Heavy chain: DNA sequence (420 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  924
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatggtat ccagtgtgag       60

gtggagctgg tggagtctgg aggaggcttg gtacagcctg ggggttctct gagactctcc      120

tgtgcaactt ctgggttcac cttcactgat cactacatga gctgggtccg ccagcctcca      180

ggaaaggcac ttgagtggtt gggatttatt agaaacaaag ctaatggtta cacaacagag      240

tacagtgcat ctgtgaaggg tcggttcacc atctccagag ataattccca aagcatcctc      300

tatcttcaaa tgaaaaccct gagaactgag gacagtgcca cttattactg tgcaagacct      360

tctgactggg actcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420


<210>  925
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 Heavy chain: Amino acid sequence (140 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  925

Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp His Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Lys Thr Leu Arg Thr Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Pro Ser Asp Trp Asp Ser Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140 


<210>  926
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 1 (FW1) 
       sequence

<400>  926
gaggtggagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc       60

tcctgtgcaa cttctgggtt caccttcact                                        90


<210>  927
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 1 (FW1) 
       sequence

<400>  927

Glu Val Glu Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr 
            20                  25                  30  


<210>  928
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  928
gatcactaca tgagc                                                        15


<210>  929
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  929

Asp His Tyr Met Ser 
1               5   


<210>  930
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 2 (FW2) 
       sequence

<400>  930
tgggtccgcc agcctccagg aaaggcactt gagtggttgg ga                          42


<210>  931
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 2 (FW2) 
       sequence

<400>  931

Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  932
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  932
tttattagaa acaaagctaa tggttacaca acagagtaca gtgcatctgt gaagggt          57


<210>  933
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  933

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  934
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 3 (FW3) 
       sequence

<400>  934
cggttcacca tctccagaga taattcccaa agcatcctct atcttcaaat gaaaaccctg       60

agaactgagg acagtgccac ttattactgt gcaaga                                 96


<210>  935
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 3 (FW3) 
       sequence

<400>  935

Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile Leu Tyr Leu Gln 
1               5                   10                  15      


Met Lys Thr Leu Arg Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  936
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  936
ccttctgact gggactcctg gtttgcttac                                        30


<210>  937
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  937

Pro Ser Asp Trp Asp Ser Trp Phe Ala Tyr 
1               5                   10  


<210>  938
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 4 (FW4) 
       sequence

<400>  938
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  939
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 heavy chain variable framework 4 (FW4) 
       sequence

<400>  939

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  940
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  940
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggtgatca agcctccatc      120

tcttgcagat ctagtcagag cattgtacat agtaatggca acacctattt agattggtac      180

ttgcagaaac caggccagtc tccaaagctc ctgatctaca gagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggactttat tactgttttc aaggttcaca tgttccgtgg      360

gcgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  941
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  941

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Trp Ala Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  942
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 1 (FW1) 
       sequence

<400>  942
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggtga tcaagcctcc       60

atctcttgc                                                               69


<210>  943
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 1 (FW1) 
       sequence

<400>  943

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  944
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  944
agatctagtc agagcattgt acatagtaat ggcaacacct atttagat                    48


<210>  945
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  945

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  946
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 2 (FW2) 
       sequence

<400>  946
tggtacttgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  947
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 2 (FW2) 
       sequence

<400>  947

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  948
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  948
agagtttcca accgattttc t                                                 21


<210>  949
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  949

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  950
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 3 (FW3) 
       sequence

<400>  950
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggactttat tactgt                                 96


<210>  951
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 3 (FW3) 
       sequence

<400>  951

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys 
            20                  25                  30          


<210>  952
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  952
tttcaaggtt cacatgttcc gtgggcg                                           27


<210>  953
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  953

Phe Gln Gly Ser His Val Pro Trp Ala 
1               5                   


<210>  954
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 4 (FW4) 
       sequence

<400>  954
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  955
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 8A9 light chain variable framework 4 (FW4) 
       sequence

<400>  955

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  956
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 Heavy chain: DNA sequence (399 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  956
atgggatgga gctatatcat cctctttttg gtcgcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagtctgg ggctgaactg gtgaagcctg gggcttcagt gaagttgtcc      120

tgcaaggctt ctggctacac cttcaccggc tactttttgt actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggggggatt aatcctgaca atggtggtat tgacttcaat      240

gagaagttca ggaacaaggc cacactgact gtagacaaat cctccagcac agcctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt attgtacatt actaataggg      360

aactattggg gccaaggcac cactctcaca gtctcctca                             399


<210>  957
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 Heavy chain: Amino acid sequence (133 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  957

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Phe Leu Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile Asn Pro Asp Asn Gly Gly Ile Asp Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Leu Leu Ile Gly Asn Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser 
    130             


<210>  958
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 1 (FW1) 
       sequence

<400>  958
caggtccaac tgcagcagtc tggggctgaa ctggtgaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc                                        90


<210>  959
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 1 (FW1) 
       sequence

<400>  959

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  960
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  960
ggctactttt tgtac                                                        15


<210>  961
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 39H5 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  961

Gly Tyr Phe Leu Tyr 
1               5   


<210>  962
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 2 (FW2) 
       sequence

<400>  962
tgggtgaagc agaggcctgg acaaggcctt gagtggattg gg                          42


<210>  963
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 2 (FW2) 
       sequence

<400>  963

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  964
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  964
gggattaatc ctgacaatgg tggtattgac ttcaatgaga agttcaggaa c                51


<210>  965
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  965

Gly Ile Asn Pro Asp Asn Gly Gly Ile Asp Phe Asn Glu Lys Phe Arg 
1               5                   10                  15      


Asn 
    


<210>  966
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 3 (FW3) 
       sequence

<400>  966
aaggccacac tgactgtaga caaatcctcc agcacagcct acatgcaact cagcagcctg       60

acatctgagg actctgcggt ctattattgt acatta                                 96


<210>  967
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 3 (FW3) 
       sequence

<400>  967

Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Leu 
            20                  25                  30          


<210>  968
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  968
ctaataggga actat                                                        15


<210>  969
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  969

Leu Ile Gly Asn Tyr 
1               5   


<210>  970
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 4 (FW4) 
       sequence

<400>  970
tggggccaag gcaccactct cacagtctcc tca                                    33


<210>  971
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 heavy chain variable framework 4 (FW4) 
       sequence

<400>  971

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  972
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  972
atgagtcctg cccagttcct gtttctgtta gtgctctgga ttcgggaaac caatggtgat       60

gttgtgatga cccagactcc actcactttg tcggtaacca ttggacagcc agcctccatc      120

tcttgcaagt caagtcagag cctcttacat agtgatggaa agacatattt gatttggttg      180

ttacagaggc caggccagtc tccaaagcgc ctaatctatc tggtgtctaa actggactct      240

ggagtccctg acaggttcac tggcagtgga tcagggacag atttcacact gaaaatcagc      300

agagtggagg ctgaggattt gggagtttat ttttgctgtc aaggtacaca ttttccgtgg      360

acgttcggtg gaggcaccat gctggaaatc aaa                                   393


<210>  973
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  973

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Glu 
1               5                   10                  15      


Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu His Ser Asp Gly Lys Thr Tyr Leu Ile Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Cys Gln Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Met Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  974
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 1 (FW1) 
       sequence

<400>  974
gatgttgtga tgacccagac tccactcact ttgtcggtaa ccattggaca gccagcctcc       60

atctcttgc                                                               69


<210>  975
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 1 (FW1) 
       sequence

<400>  975

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  976
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  976
aagtcaagtc agagcctctt acatagtgat ggaaagacat atttgatt                    48


<210>  977
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  977

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Ile 
1               5                   10                  15      


<210>  978
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 2 (FW2) 
       sequence

<400>  978
tggttgttac agaggccagg ccagtctcca aagcgcctaa tctat                       45


<210>  979
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 2 (FW2) 
       sequence

<400>  979

Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  980
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  980
ctggtgtcta aactggactc t                                                 21


<210>  981
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  981

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  982
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 3 (FW3) 
       sequence

<400>  982
ggagtccctg acaggttcac tggcagtgga tcagggacag atttcacact gaaaatcagc       60

agagtggagg ctgaggattt gggagtttat ttttgc                                 96


<210>  983
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 3 (FW3) 
       sequence

<400>  983

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  984
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  984
tgtcaaggta cacattttcc gtggacg                                           27


<210>  985
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  985

Cys Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  986
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 4 (FW4) 
       sequence

<400>  986
ttcggtggag gcaccatgct ggaaatcaaa                                        30


<210>  987
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18G12 light chain variable framework 4 (FW4) 
       sequence

<400>  987

Phe Gly Gly Gly Thr Met Leu Glu Ile Lys 
1               5                   10  


<210>  988
<211>  416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 Heavy chain: DNA sequence (417 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  988
atgaacttcg ggttcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgatgctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtcagcctc tggattcact ttcagtacct atgccatgtc ttggattcgc cagactccag      180

agaagaggct ggagtgggtc gcatccattg gtcgtgctgg ttccacctac tattcagaca      240

gtgtgaaggg ccgattcacc atctccagag ataatgtccg gaacatcctg tacctgcaaa      300

tgagcagtct gaggtctgag gacacggcca tgtattactg tgctagaggc ccgatctaca      360

atgattacga cgagtttgct tactggggcc aagggactct ggtcactgtc tctgca          416


<210>  989
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 Heavy chain: Amino acid sequence (139 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  989

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 


<210>  990
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 1 (FW1) 
       sequence

<400>  990
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  991
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 1 (FW1) 
       sequence

<400>  991

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  992
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  992
acctatgcca tgtct                                                        15


<210>  993
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  993

Thr Tyr Ala Met Ser 
1               5   


<210>  994
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 2 (FW2) 
       sequence

<400>  994
tggattcgcc agactccaga gaagaggctg gagtgggtcg ca                          42


<210>  995
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 2 (FW2) 
       sequence

<400>  995

Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  996
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  996
tccattggtc gtgctggttc cacctactat tcagacagtg tgaagggc                    48


<210>  997
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  997

Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  998
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 3 (FW3) 
       sequence

<400>  998
cgattcacca tctccagaga taatgtccgg aacatcctgt acctgcaaat gagcagtctg       60

aggtctgagg acacggccat gtattactgt gctaga                                 96


<210>  999
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 3 (FW3) 
       sequence

<400>  999

Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1000
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1000
ggcccgatct acaatgatta cgacgagttt gcttac                                 36


<210>  1001
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1001

Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr 
1               5                   10          


<210>  1002
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1002
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  1003
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1003

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  1004
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 Light chain: DNA sequence (396 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1004
atggaatcac agactcaggt cttcctctcc ctgctgctct gggtatctgg tacctgtggg       60

aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact      120

atgagctgta agtccagtca aagtgtttta tacagttcaa atcagaagaa ctatttggcc      180

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      240

gaatctggtg tccctgatcg cttcacaggc agtggatctg ggacagattt tactcttacc      300

atcagcagtg tacaagctga agacctggca gtttattact gtcatcaata cctctcctcg      360

ctcacgttcg gtgctgggac caagctggag ctgaaa                                396


<210>  1005
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 Light chain: Amino acid sequence (132 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1005

Met Glu Ser Gln Thr Gln Val Phe Leu Ser Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys 
    130         


<210>  1006
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 1 (FW1) 
       sequence

<400>  1006
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact       60

atgagctgt                                                               69


<210>  1007
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 1 (FW1) 
       sequence

<400>  1007

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  1008
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1008
aagtccagtc aaagtgtttt atacagttca aatcagaaga actatttggc c                51


<210>  1009
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1009

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  1010
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 2 (FW2) 
       sequence

<400>  1010
tggtaccagc agaaaccagg gcagtctcct aaactgctga tctac                       45


<210>  1011
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 2 (FW2) 
       sequence

<400>  1011

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1012
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1012
tgggcatcca ctagggaatc t                                                 21


<210>  1013
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1013

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  1014
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 3 (FW3) 
       sequence

<400>  1014
ggtgtccctg atcgcttcac aggcagtgga tctgggacag attttactct taccatcagc       60

agtgtacaag ctgaagacct ggcagtttat tactgt                                 96


<210>  1015
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 3 (FW3) 
       sequence

<400>  1015

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1016
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1016
catcaatacc tctcctcgct cacg                                              24


<210>  1017
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1017

His Gln Tyr Leu Ser Ser Leu Thr 
1               5               


<210>  1018
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 4 (FW4) 
       sequence

<400>  1018
ttcggtgctg ggaccaagct ggagctgaaa                                        30


<210>  1019
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 20A10 light chain variable framework 4 (FW4) 
       sequence

<400>  1019

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  1020
<211>  413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 Heavy chain: DNA sequence (414 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1020
atgaacttcg ggctcagctt gattttcctt gccctcattt taaaaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggagactta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggtttcac tttcagtagt tatggaatgt cttgggttcg ccagactcca      180

gacaagaggc tggagtgggt cgcaaccatt agtaatggtg gtagacacac cttctatcca      240

gacagtgtga aggggcgatt caccatctcc agagacaatg ccaagaacac cctgtatctg      300

caaatgagca gtctgaagtt gaggacacag ccatgtattt atgtgtaaga cagactggga      360

cggagggctg gtttgcttac tggggccaag ggactctggt cactgtctct gca             413


<210>  1021
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 Heavy chain: Amino acid sequence (138 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1021

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135             


<210>  1022
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1022
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggttt cactttcagt                                        90


<210>  1023
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1023

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1024
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1024
agttatggaa tgtct                                                        15


<210>  1025
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1025

Ser Tyr Gly Met Ser 
1               5   


<210>  1026
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1026
tgggttcgcc agactccaga caagaggctg gagtgggtcg ca                          42


<210>  1027
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1027

Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1028
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1028
accattagta atggtggtag acacaccttc tatccagaca gtgtgaaggg g                51


<210>  1029
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1029

Thr Ile Ser Asn Gly Gly Arg His Thr Phe Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  1030
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1030
cgattcacca tctccagaga caatgccaag aacaccctgt atctgcaaat gagcagtctg       60

aagtctgagg acacagccat gtatttatgt gtaaga                                 96


<210>  1031
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1031

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Leu Cys Val Arg 
            20                  25                  30          


<210>  1032
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1032
cagactggga cggagggctg gtttgcttac                                        30


<210>  1033
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1033

Gln Thr Gly Thr Glu Gly Trp Phe Ala Tyr 
1               5                   10  


<210>  1034
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1034
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  1035
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1035

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  1036
<211>  392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1036
atgagtcctg cccagttcct gtttctgtta gtgctctgga ttcgggaaac caacggtgat       60

gttgtgatga cccagactcc actcactttg tcggttacca ttggacaacc agcctccatc      120

tcttgcaagt caagtcagag cctcttagat agtgatggaa agacatattt gaattggttg      180

ttacagaggc caggccagtc tccaaagcgc ctaatctatc tggtgtctaa actggactct      240

ggagtccctg acaggttcac tggcagtgga tcagggacag atttcacact gaaaatcagc      300

agagggaggc tgaggatttg ggagtttatt attgctggca aggtacacat tttcctcaga      360

cgttcggtgg aggcaccaag ctggaaatca aa                                    392


<210>  1037
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1037

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Glu 
1               5                   10                  15      


Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Thr His Phe Pro Gln Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1038
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 1 (FW1) 
       sequence

<400>  1038
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgc                                                               69


<210>  1039
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 1 (FW1) 
       sequence

<400>  1039

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1040
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1040
aagtcaagtc agagcctctt agatagtgat ggaaagacat atttgaat                    48


<210>  1041
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1041

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  1042
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 2 (FW2) 
       sequence

<400>  1042
tggttgttac agaggccagg ccagtctcca aagcgcctaa tctat                       45


<210>  1043
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 2 (FW2) 
       sequence

<400>  1043

Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1044
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1044
ctggtgtcta aactggactc t                                                 21


<210>  1045
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1045

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  1046
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 3 (FW3) 
       sequence

<400>  1046
ggagtccctg acaggttcac tggcagtgga tcagggacag atttcacact gaaaatcagc       60

agagtggagg ctgaggattt gggagtttat tattgc                                 96


<210>  1047
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 3 (FW3) 
       sequence

<400>  1047

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1048
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1048
tggcaaggta cacattttcc tcagacg                                           27


<210>  1049
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1049

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  1050
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 4 (FW4) 
       sequence

<400>  1050
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  1051
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 25E6 light chain variable framework 4 (FW4) 
       sequence

<400>  1051

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1052
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 Heavy chain: DNA sequence (399 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1052
atgggatgga gctatatcat cctctttttg gtagcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgcagcctg gggcttcagt gaagttgtcc      120

tgcaaggctt ctggctacac cttcaccggc tactttttgt actgggtgaa gcagaggcct      180

ggacatggcc ttgagtggat tgggggaatt catcctagca atggtgatac tgacttcaat      240

gagaagttca agaacaaggc cacactgact gtagacatat cctccagcac tgcctacatg      300

caactcagca gcctgacatc tgaggactct gcggtctatt attgtacatt actaataggg      360

gtctactggg gccaaggcac cactctcaca gtctcctca                             399


<210>  1053
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 Heavy chain: Amino acid sequence (133 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1053

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Gln 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Gly Tyr Phe Leu Tyr Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile His Pro Ser Asn Gly Asp Thr Asp Phe Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Leu Leu Ile Gly Val Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser 
    130             


<210>  1054
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1054
caggtccaac tgcagcagcc tggggctgaa ctggtgcagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta caccttcacc                                        90


<210>  1055
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1055

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  1056
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1056
ggctactttt tgtac                                                        15


<210>  1057
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1057

Gly Tyr Phe Leu Tyr 
1               5   


<210>  1058
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1058
tgggtgaagc agaggcctgg acatggcctt gagtggattg gg                          42


<210>  1059
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1059

Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1060
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1060
ggaattcatc ctagcaatgg tgatactgac ttcaatgaga agttcaagaa c                51


<210>  1061
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1061

Gly Ile His Pro Ser Asn Gly Asp Thr Asp Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  1062
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1062
aaggccacac tgactgtaga catatcctcc agcactgcct acatgcaact cagcagcctg       60

acatctgagg actctgcggt ctattattgt acatta                                 96


<210>  1063
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1063

Lys Ala Thr Leu Thr Val Asp Ile Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Leu 
            20                  25                  30          


<210>  1064
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1064
ctaatagggg tctac                                                        15


<210>  1065
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1065

Leu Ile Gly Val Tyr 
1               5   


<210>  1066
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1066
tggggccaag gcaccactct cacagtctcc tca                                    33


<210>  1067
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1067

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  1068
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1068
atgagtcctg cccagttcct gtttctgtta gtgctctgga ttcgggaaac caacggtgat       60

gttgtgatga cccagactcc actcactttg tcggttacca ttggacaacc agcctccatc      120

tcttgcaagt caagtcagag cctcttacat agtgatggaa agacatattt gatttggttg      180

ttacagaggc caggccagtc tccaaagcgc ctaatctatc tggtgtctaa actggactct      240

ggagtccctg acaggttcac cggcagtgga tcagggacag atttcacact gaaaatcagc      300

agagtggagg ctgaggattt gggagtttat ttttgctgtc aaggtacaca ttttccgtgg      360

acgttcggtg gaggcaccat gctggaaatc aaa                                   393


<210>  1069
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1069

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Glu 
1               5                   10                  15      


Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu His Ser Asp Gly Lys Thr Tyr Leu Ile Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Cys Gln Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Met Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1070
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 1 (FW1) 
       sequence

<400>  1070
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgc                                                               69


<210>  1071
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 1 (FW1) 
       sequence

<400>  1071

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  1072
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1072
aagtcaagtc agagcctctt acatagtgat ggaaagacat atttgatt                    48


<210>  1073
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1073

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Ile 
1               5                   10                  15      


<210>  1074
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 2 (FW2) 
       sequence

<400>  1074
tggttgttac agaggccagg ccagtctcca aagcgcctaa tctat                       45


<210>  1075
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 2 (FW2) 
       sequence

<400>  1075

Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  1076
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1076
ctggtgtcta aactggactc t                                                 21


<210>  1077
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1077

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  1078
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 3 (FW3) 
       sequence

<400>  1078
ggagtccctg acaggttcac cggcagtgga tcagggacag atttcacact gaaaatcagc       60

agagtggagg ctgaggattt gggagtttat ttttgc                                 96


<210>  1079
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 3 (FW3) 
       sequence

<400>  1079

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  1080
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1080
tgtcaaggta cacattttcc gtggacg                                           27


<210>  1081
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1081

Cys Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  1082
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 4 (FW4) 
       sequence

<400>  1082
ttcggtggag gcaccatgct ggaaatcaaa                                        30


<210>  1083
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 28F9 light chain variable framework 4 (FW4) 
       sequence

<400>  1083

Phe Gly Gly Gly Thr Met Leu Glu Ile Lys 
1               5                   10  


<210>  1084
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 Heavy chain: DNA sequence (411 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1084
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaaacttg aggagtctgg aggaggcttg gtgcaacctg ggggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttaatgac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agaagcacag ctaatattca tacaacatac      240

tatgctgagt ctgtccaagg gaggttcacc atctcaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt gagagctgaa gacactggca tttattattg taccccatta      360

ctctacggat ttgcttactg gggccaaggg actctggtca ctgtctctgc a               411


<210>  1085
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 Heavy chain: Amino acid sequence (137 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1085

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Thr Ala Asn Ile His Thr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Pro Leu Leu Tyr Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  1086
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1086
gaagtgaaac ttgaggagtc tggaggaggc ttggtgcaac ctgggggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttaat                                        90


<210>  1087
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1087

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 
            20                  25                  30  


<210>  1088
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1088
gacgcctgga tggac                                                        15


<210>  1089
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1089

Asp Ala Trp Met Asp 
1               5   


<210>  1090
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1090
tgggtccgcc agtctccaga gaaggggctt gagtgggttg ct                          42


<210>  1091
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1091

Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1092
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1092
gaaattagaa gcacagctaa tattcataca acatactatg ctgagtctgt ccaaggg          57


<210>  1093
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1093

Glu Ile Arg Ser Thr Ala Asn Ile His Thr Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Gln Gly 
            


<210>  1094
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1094
aggttcacca tctcaagaga tgattccaaa agtagtgtct acctgcaaat gaacagcttg       60

agagctgaag acactggcat ttattattgt acccca                                 96


<210>  1095
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1095

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Pro 
            20                  25                  30          


<210>  1096
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1096
ttactctacg gatttgctta c                                                 21


<210>  1097
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1097

Leu Leu Tyr Gly Phe Ala Tyr 
1               5           


<210>  1098
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1098
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  1099
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1099

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  1100
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1100
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaagtcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagaa ctagtcagag ccttgtacac agtaatggaa acacctattt acattggcac      180

ctgcagaagc caggccagtc tccaaaggtc ctgatctaca aagtttccag ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcggggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaaatacaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaa                                   393


<210>  1101
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1101

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Thr Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp His Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Asn Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1102
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 1 (FW1) 
       sequence

<400>  1102
gatgttgtga tgacccaaag tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  1103
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 1 (FW1) 
       sequence

<400>  1103

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1104
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1104
agaactagtc agagccttgt acacagtaat ggaaacacct atttacat                    48


<210>  1105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1105

Arg Thr Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  1106
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 2 (FW2) 
       sequence

<400>  1106
tggcacctgc agaagccagg ccagtctcca aaggtcctga tctac                       45


<210>  1107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 2 (FW2) 
       sequence

<400>  1107

Trp His Leu Gln Lys Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr 
1               5                   10                  15  


<210>  1108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1108
aaagtttcca gccgattttc t                                                 21


<210>  1109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1109

Lys Val Ser Ser Arg Phe Ser 
1               5           


<210>  1110
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 3 (FW3) 
       sequence

<400>  1110
ggggtcccag acaggttcag tggcagtgga tcggggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat ttctgc                                 96


<210>  1111
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 3 (FW3) 
       sequence

<400>  1111

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  1112
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1112
tctcaaaata cacatgttcc gtacacg                                           27


<210>  1113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1113

Ser Gln Asn Thr His Val Pro Tyr Thr 
1               5                   


<210>  1114
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 4 (FW4) 
       sequence

<400>  1114
ttcggagggg ggaccaagct ggaaataaaa                                        30


<210>  1115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 18B4 light chain variable framework 4 (FW4) 
       sequence

<400>  1115

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1116
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody IE4 Heavy chain: DNA sequence (408 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1116
atggaatggc cttgtatctt tctcttcctc ctgtcagtaa ctgaaggtgt ccactcccag       60

gttcagctgc agcagtctgg ggctgagctg gtgaggcctg ggtcctcagt gaagatttcc      120

tgtaaggctt ctggctatgc attcagtacc tactggatga actgggtgaa gcagaggcct      180

ggacagggtc ttgagtggat tggacagatt tatcctggag atagtgatac taactacaat      240

ggaaagttca agggtaaagc cacactgact gcagacaagt cctccaacac agcctacatg      300

cagctcagca gcctaacatc tgaggactct gcggtctttt tctgtgcaag aggtaaccac      360

gcctctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   408


<210>  1117
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody IE4 Heavy chain: Amino acid sequence (136 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1117

Met Glu Trp Pro Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Glu Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Thr Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Ser Asp Thr Asn Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Phe Phe Cys Ala Arg Gly Asn His Ala Ser Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     


<210>  1118
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody IE4 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1118
caggttcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgtaagg cttctggcta tgcattcagt                                        90


<210>  1119
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody IE4 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1119

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
            20                  25                  30  


<210>  1120

<400>  1120
000

<210>  1121

<400>  1121
000

<210>  1122

<400>  1122
000

<210>  1123

<400>  1123
000

<210>  1124

<400>  1124
000

<210>  1125

<400>  1125
000

<210>  1126

<400>  1126
000

<210>  1127

<400>  1127
000

<210>  1128

<400>  1128
000

<210>  1129

<400>  1129
000

<210>  1130

<400>  1130
000

<210>  1131

<400>  1131
000

<210>  1132

<400>  1132
000

<210>  1133

<400>  1133
000

<210>  1134

<400>  1134
000

<210>  1135

<400>  1135
000

<210>  1136

<400>  1136
000

<210>  1137

<400>  1137
000

<210>  1138

<400>  1138
000

<210>  1139

<400>  1139
000

<210>  1140

<400>  1140
000

<210>  1141

<400>  1141
000

<210>  1142

<400>  1142
000

<210>  1143

<400>  1143
000

<210>  1144

<400>  1144
000

<210>  1145

<400>  1145
000

<210>  1146

<400>  1146
000

<210>  1147

<400>  1147
000

<210>  1148

<400>  1148
000

<210>  1149

<400>  1149
000

<210>  1150

<400>  1150
000

<210>  1151

<400>  1151
000

<210>  1152

<400>  1152
000

<210>  1153

<400>  1153
000

<210>  1154

<400>  1154
000

<210>  1155

<400>  1155
000

<210>  1156

<400>  1156
000

<210>  1157

<400>  1157
000

<210>  1158

<400>  1158
000

<210>  1159

<400>  1159
000

<210>  1160

<400>  1160
000

<210>  1161

<400>  1161
000

<210>  1162

<400>  1162
000

<210>  1163

<400>  1163
000

<210>  1164

<400>  1164
000

<210>  1165

<400>  1165
000

<210>  1166

<400>  1166
000

<210>  1167

<400>  1167
000

<210>  1168

<400>  1168
000

<210>  1169

<400>  1169
000

<210>  1170

<400>  1170
000

<210>  1171

<400>  1171
000

<210>  1172

<400>  1172
000

<210>  1173

<400>  1173
000

<210>  1174

<400>  1174
000

<210>  1175

<400>  1175
000

<210>  1176

<400>  1176
000

<210>  1177

<400>  1177
000

<210>  1178

<400>  1178
000

<210>  1179

<400>  1179
000

<210>  1180

<400>  1180
000

<210>  1181

<400>  1181
000

<210>  1182

<400>  1182
000

<210>  1183

<400>  1183
000

<210>  1184

<400>  1184
000

<210>  1185

<400>  1185
000

<210>  1186

<400>  1186
000

<210>  1187

<400>  1187
000

<210>  1188

<400>  1188
000

<210>  1189

<400>  1189
000

<210>  1190

<400>  1190
000

<210>  1191

<400>  1191
000

<210>  1192

<400>  1192
000

<210>  1193

<400>  1193
000

<210>  1194

<400>  1194
000

<210>  1195

<400>  1195
000

<210>  1196

<400>  1196
000

<210>  1197

<400>  1197
000

<210>  1198

<400>  1198
000

<210>  1199

<400>  1199
000

<210>  1200
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1200
acctactgga tgaac                                                        15


<210>  1201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1201

Thr Tyr Trp Met Asn 
1               5   


<210>  1202
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1202
tgggtgaagc agaggcctgg acagggtctt gagtggattg ga                          42


<210>  1203
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1203

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1204
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1204
cagatttatc ctggagatag tgatactaac tacaatggaa agttcaaggg t                51


<210>  1205
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1205

Gln Ile Tyr Pro Gly Asp Ser Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  1206
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1206
aaagccacac tgactgcaga caagtcctcc aacacagcct acatgcagct cagcagccta       60

acatctgagg actctgcggt ctttttctgt gcaaga                                 96


<210>  1207
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1207

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys Ala Arg 
            20                  25                  30          


<210>  1208
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1208
ggtaaccacg cctctatgga ctac                                              24


<210>  1209
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1209

Gly Asn His Ala Ser Met Asp Tyr 
1               5               


<210>  1210
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1210
tggggtcaag gaacctcagt caccgtctcc tca                                    33


<210>  1211
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1211

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  1212
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody IE4 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1212
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaaaaacaca tgttccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  1213
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Antibody IE4 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1213

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Lys Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1214
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 1 (FW1) 
       sequence

<400>  1214
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  1215
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 1 (FW1) 
       sequence

<400>  1215

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1216
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1216
agatctagtc agagccttgt acacagtaat ggaaacacct atttacat                    48


<210>  1217
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1217

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  1218
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 2 (FW2) 
       sequence

<400>  1218
tggtacctgc agaagccagg ccagtctcca aagctcctga tctac                       45


<210>  1219
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 2 (FW2) 
       sequence

<400>  1219

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1220
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1220
aaagtttcca accgattttc t                                                 21


<210>  1221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1221

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1222
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 3 (FW3) 
       sequence

<400>  1222
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat ttctgc                                 96


<210>  1223
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 3 (FW3) 
       sequence

<400>  1223

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  1224
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1224
tctcaaaaaa cacatgttcc gtggacg                                           27


<210>  1225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1225

Ser Gln Lys Thr His Val Pro Trp Thr 
1               5                   


<210>  1226
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 4 (FW4) 
       sequence

<400>  1226
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  1227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody IE4 light chain variable framework 4 (FW4) 
       sequence

<400>  1227

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1228
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 Heavy chain: DNA sequence (411 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1228
atgtacttgg gactgaacta tgtattcata gtttttctct taaatggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtacaacctg gaggatccat gaaactctct      120

tgtgctgcct ctggattcac ttttagtgac gcctggatgg actgggtccg ccagtctcca      180

gagaaggggc ttgaatgggt tgctgaaatt agaagcaaag ctactaatca tgcaacatac      240

tatgctgagt ctgtgaaagg gaggttcacc atctcaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacagctt aagagctgaa gacactggca tttattactg taccccccta      360

ctttacgggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               411


<210>  1229
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 Heavy chain: Amino acid sequence (137 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1229

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Thr Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Pro Leu Leu Tyr Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  1230
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1230
gaagtgaagc ttgaggagtc tggaggaggc ttggtacaac ctggaggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttagt                                        90


<210>  1231
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1231

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1232
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1232
gacgcctgga tggac                                                        15


<210>  1233
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1233

Asp Ala Trp Met Asp 
1               5   


<210>  1234
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1234
tgggtccgcc agtctccaga gaaggggctt gaatgggttg ct                          42


<210>  1235
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1235

Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1236
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1236
gaaattagaa gcaaagctac taatcatgca acatactatg ctgagtctgt gaaaggg          57


<210>  1237
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1237

Glu Ile Arg Ser Lys Ala Thr Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  1238
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1238
aggttcacca tctcaagaga tgattccaaa agtagtgtct acctgcaaat gaacagctta       60

agagctgaag acactggcat ttattactgt accccc                                 96


<210>  1239
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1239

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Pro 
            20                  25                  30          


<210>  1240
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1240
ctactttacg ggtttgctta c                                                 21


<210>  1241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1241

Leu Leu Tyr Gly Phe Ala Tyr 
1               5           


<210>  1242
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1242
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  1243
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1243

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  1244
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1244
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctggtcagag ccttgtacac agtaatggac acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaggctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcaagggcag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaactacaca tgttccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  1245
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1245

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Ala Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Thr Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1246
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 1 (FW1) 
       sequence

<400>  1246
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  1247
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 1 (FW1) 
       sequence

<400>  1247

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1248
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1248
agatctggtc agagccttgt acacagtaat ggacacacct atttacat                    48


<210>  1249
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1249

Arg Ser Gly Gln Ser Leu Val His Ser Asn Gly His Thr Tyr Leu His 
1               5                   10                  15      


<210>  1250
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 2 (FW2) 
       sequence

<400>  1250
tggtacctgc agaagccagg ccagtctcca aggctcctga tctac                       45


<210>  1251
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 2 (FW2) 
       sequence

<400>  1251

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1252
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1252
aaagtttcca accgattttc t                                                 21


<210>  1253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1253

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1254
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 3 (FW3) 
       sequence

<400>  1254
ggggtcccag acaggttcag tggcagtgga tcaagggcag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat ttctgc                                 96


<210>  1255
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 3 (FW3) 
       sequence

<400>  1255

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Ala Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  1256
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1256
tctcaaacta cacatgttcc gtggacg                                           27


<210>  1257
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1257

Ser Gln Thr Thr His Val Pro Trp Thr 
1               5                   


<210>  1258
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 4 (FW4) 
       sequence

<400>  1258
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  1259
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 29H1 light chain variable framework 4 (FW4) 
       sequence

<400>  1259

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1260
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 Heavy chain: DNA sequence (399 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1260
atggaaaggc actggatctt tctcttcctg ttttcagtaa ctgcaggtgt ccactcccag       60

gtccagcttc agcagtctgg ggctgaactg gcaaaacctg gggcctcagt gaagatgtcc      120

tgcaaggctt ctggctacac ctttactagc tactggatgc actgggtaaa acagaggcct      180

ggacagggtc tggaatggat tggatacatt aatcctagca ctggttatac tgagtacaat      240

cagaagttca aggacaaggc cacattgact gcagacaaat cctccagcac agcctacatg      300

caactgagca gcctgacatc tgaggactct gcagtctatt actgtgcaag agcctacatt      360

gactactggg gccaaggcac cactctcaca gtctcctca                             399


<210>  1261
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 Heavy chain: Amino acid sequence (133 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1261

Met Glu Arg His Trp Ile Phe Leu Phe Leu Phe Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Ile Asp Tyr Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser 
    130             


<210>  1262
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1262
caggtccagc ttcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttact                                        90


<210>  1263
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1263

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  1264
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1264
agctactgga tgcac                                                        15


<210>  1265
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1265

Ser Tyr Trp Met His 
1               5   


<210>  1266
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1266
tgggtaaaac agaggcctgg acagggtctg gaatggattg ga                          42


<210>  1267
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1267

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1268
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1268
tacattaatc ctagcactgg ttatactgag tacaatcaga agttcaagga c                51


<210>  1269
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1269

Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  1270
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1270
aaggccacat tgactgcaga caaatcctcc agcacagcct acatgcaact gagcagcctg       60

acatctgagg actctgcagt ctattactgt gcaaga                                 96


<210>  1271
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1271

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1272
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1272
gcctacattg actac                                                        15


<210>  1273
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1273

Ala Tyr Ile Asp Tyr 
1               5   


<210>  1274
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1274
tggggccaag gcaccactct cacagtctcc tca                                    33


<210>  1275
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1275

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  1276
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1276
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccttc      120

tcttgcagat ctagtcagag cattgtacat agtaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcaac      300

agagtggagg ctgaggatct gggagtttat tactgctttc aagtttcaca ttttccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaa                                   393


<210>  1277
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1277

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Phe Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Val Ser His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1278
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 1 (FW1) 
       sequence

<400>  1278
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

ttctcttgc                                                               69


<210>  1279
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 1 (FW1) 
       sequence

<400>  1279

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Phe Ser Cys 
            20              


<210>  1280
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1280
agatctagtc agagcattgt acatagaaat ggaaacacct atttagaa                    48


<210>  1281
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1281

Arg Ser Ser Gln Ser Ile Val His Arg Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  1282
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 2 (FW2) 
       sequence

<400>  1282
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  1283
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 2 (FW2) 
       sequence

<400>  1283

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1284
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1284
aaagtttcca accgattttc t                                                 21


<210>  1285
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1285

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1286
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 3 (FW3) 
       sequence

<400>  1286
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcaac       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  1287
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 3 (FW3) 
       sequence

<400>  1287

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1288
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1288
tttcaagttt cacattttcc gtggacg                                           27


<210>  1289
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1289

Phe Gln Val Ser His Phe Pro Trp Thr 
1               5                   


<210>  1290
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 4 (FW4) 
       sequence

<400>  1290
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  1291
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 31A1 light chain variable framework 4 (FW4) 
       sequence

<400>  1291

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1292
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 Heavy chain: DNA sequence (411 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1292
atgtacttgg gactgaactg tgtattcata gtttttctct taaaaggtgt ccagagtgaa       60

gtgaagcttg aggagtctgg aggaggcttg gtgcaatctg gaggatccat gaaactctcc      120

tgtgttgcct ctggattcac tttcagtaat tactggatga actgggtccg ccagtctcca      180

gagaaggggc ttgagtgggt tgctgaaatt agattgaaat ctaataatta tgcaatacat      240

tatgcggagt ctgtgaaggg gaggttcacc atctcaagag atgattccaa aagtagtgtc      300

tacctgcaaa tgaacaactt aagagctgaa gacactggca tttattactg taccagggtc      360

ccgggactgg atgcttactg gggccaaggg actctggtca ctgtctctgc a               411


<210>  1293
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 Heavy chain: Amino acid sequence (137 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1293

Met Tyr Leu Gly Leu Asn Cys Val Phe Ile Val Phe Leu Leu Lys Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Ser Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Ile His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Arg Val Pro Gly Leu Asp Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  1294
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1294
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaat ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cactttcagt                                        90


<210>  1295
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1295

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1296
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1296
aattactgga tgaac                                                        15


<210>  1297
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1297

Asn Tyr Trp Met Asn 
1               5   


<210>  1298
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1298
tgggtccgcc agtctccaga gaaggggctt gagtgggttg ct                          42


<210>  1299
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1299

Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1300
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1300
gaaattagat tgaaatctaa taattatgca atacattatg cggagtctgt gaagggg          57


<210>  1301
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1301

Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Ile His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  1302
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1302
aggttcacca tctcaagaga tgattccaaa agtagtgtct acctgcaaat gaacaactta       60

agagctgaag acactggcat ttattactgt accagg                                 96


<210>  1303
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1303

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  1304
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1304
gtcccgggac tggatgctta c                                                 21


<210>  1305
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1305

Val Pro Gly Leu Asp Ala Tyr 
1               5           


<210>  1306
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1306
tggggccaag ggactctggt cactgtctct gca                                    33


<210>  1307
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1307

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  1308
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 Light chain: DNA sequence (393 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1308
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agtgtggagg ctgaggatct gggagtttat ttctgctctc aaattacaca tgttccgtac      360

acgttcggag gggggaccaa tctggaaata aaa                                   393


<210>  1309
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 Light chain: Amino acid sequence (131 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1309

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Ser Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ile Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  1310
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 1 (FW1) 
       sequence

<400>  1310
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  1311
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 1 (FW1) 
       sequence

<400>  1311

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1312
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1312
agatctagtc agagccttgt acacagtaat ggaaacacct atttacat                    48


<210>  1313
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1313

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  1314
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 2 (FW2) 
       sequence

<400>  1314
tggtacctgc agaagccagg ccagtctcca aagctcctga tctac                       45


<210>  1315
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 2 (FW2) 
       sequence

<400>  1315

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1316
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1316
aaagtttcca accgattttc t                                                 21


<210>  1317
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1317

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1318
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 3 (FW3) 
       sequence

<400>  1318
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agtgtggagg ctgaggatct gggagtttat ttctgc                                 96


<210>  1319
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 3 (FW3) 
       sequence

<400>  1319

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Ser Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  1320
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1320
tctcaaatta cacatgttcc gtacacg                                           27


<210>  1321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1321

Ser Gln Ile Thr His Val Pro Tyr Thr 
1               5                   


<210>  1322
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 4 (FW4) 
       sequence

<400>  1322
ttcggagggg ggaccaatct ggaaataaaa                                        30


<210>  1323
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 32C1 light chain variable framework 4 (FW4) 
       sequence

<400>  1323

Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
1               5                   10  


<210>  1324
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 Heavy chain: DNA sequence (423 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1324
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagacctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagctt ctggcttcaa cattaaagac acctttatgc actgggtgaa gcagaggcct      180

gaacagggcc tggagtggat tggaaggatt gatcctgcga atggtaatac taaatatgac      240

ccgaaattcc agggcaaggc cactataaca gcagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctaa accgtatggt      360

aactacggct attactatgc tttggactac tggggtcaag gaacctcagt caccgtctcc      420

tca                                                                    423


<210>  1325
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 Heavy chain: Amino acid sequence (141 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1325

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Phe Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Pro Tyr Gly Asn Tyr Gly Tyr Tyr Tyr Ala Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210>  1326
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1326
gaggttcagc tgcagcagtc tggggcagac cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa                                        90


<210>  1327
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 1 (FW1) 
       sequence

<400>  1327

Glu Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys 
            20                  25                  30  


<210>  1328
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1328
gacaccttta tgcac                                                        15


<210>  1329
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1329

Asp Thr Phe Met His 
1               5   


<210>  1330
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1330
tgggtgaagc agaggcctga acagggcctg gagtggattg ga                          42


<210>  1331
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 2 (FW2) 
       sequence

<400>  1331

Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  1332
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1332
aggattgatc ctgcgaatgg taatactaaa tatgacccga aattccaggg c                51


<210>  1333
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1333

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  1334
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1334
aaggccacta taacagcaga cacatcctcc aacacagcct acctgcagct cagcagcctg       60

acatctgagg acactgccgt ctattactgt gctaaa                                 96


<210>  1335
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 3 (FW3) 
       sequence

<400>  1335

Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  1336
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1336
ccgtatggta actacggcta ttactatgct ttggactac                              39


<210>  1337
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1337

Pro Tyr Gly Asn Tyr Gly Tyr Tyr Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  1338
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1338
tggggtcaag gaacctcagt caccgtctcc tca                                    33


<210>  1339
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 heavy chain variable framework 4 (FW4) 
       sequence

<400>  1339

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  1340
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 Light chain: DNA sequence (381 bp) - Signal 
       sequenceFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1340
atgaggttcc aggttcaggt tctggggctc cttctgctct ggatatcagg tgcccagtgt       60

gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact      120

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agagaaacct      180

gggaaaacta ataagcttct tatctactct ggatccactt tgcaatctgg aattccatca      240

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      300

gaagattttg caatgtatta ctgtcaacag cataatgaat tcccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210>  1341
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 Light chain: Amino acid sequence (127 aa) - 
       Signal peptideFR1CDR1FR2CDR2FR3CDR3FR4

<400>  1341

Met Arg Phe Gln Val Gln Val Leu Gly Leu Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Gln Cys Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala 
            20                  25                  30          


Ala Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser 
        35                  40                  45              


Ile Ser Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  1342
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 1 (FW1) 
       sequence

<400>  1342
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgc                                                               69


<210>  1343
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 1 (FW1) 
       sequence

<400>  1343

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys 
            20              


<210>  1344
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1344
agggcaagta agagcattag caaatattta gcc                                    33


<210>  1345
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable complementarity 
       determining regions 1 (CDR1) sequence

<400>  1345

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  1346
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 2 (FW2) 
       sequence

<400>  1346
tggtatcaag agaaacctgg gaaaactaat aagcttctta tctac                       45


<210>  1347
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 2 (FW2) 
       sequence

<400>  1347

Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1348
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1348
tctggatcca ctttgcaatc t                                                 21


<210>  1349
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable complementarity 
       determining regions 2 (CDR2) sequence

<400>  1349

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  1350
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 3 (FW3) 
       sequence

<400>  1350
ggaattccat caaggttcag tggcagtgga tctggtacag atttcactct caccatcagt       60

agcctggagc ctgaagattt tgcaatgtat tactgt                                 96


<210>  1351
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 3 (FW3) 
       sequence

<400>  1351

Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys 
            20                  25                  30          


<210>  1352
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1352
caacagcata atgaattccc gtggacg                                           27


<210>  1353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable complementarity 
       determining regions 3 (CDR3) sequence

<400>  1353

Gln Gln His Asn Glu Phe Pro Trp Thr 
1               5                   


<210>  1354
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 4 (FW4) 
       sequence

<400>  1354
ttcggtggag gcaccaagct ggaaatcaaa                                        30


<210>  1355
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 45C11 light chain variable framework 4 (FW4) 
       sequence

<400>  1355

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1356
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 1 (FW1) sequence

<400>  1356
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  1357
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 1 (FW1) sequence

<400>  1357

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1358
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1358
acctatgcca tgtct                                                        15


<210>  1359
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1359

Thr Tyr Ala Met Ser 
1               5   


<210>  1360
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 2 (FW2) sequence

<400>  1360
tgggttcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  1361
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 2 (FW2) sequence

<400>  1361

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1362
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1362
gccattagta atggtggtgg ttacacctac tatccagaca gtctgaaggg g                51


<210>  1363
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1363

Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  1364
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 3 (FW3) sequence

<400>  1364
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aggtctgagg acacggccac gtattactgt gcaaga                                 96


<210>  1365
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 3 (FW3) sequence

<400>  1365

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1366
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1366
cgttactatg atcactactt tgactac                                           27


<210>  1367
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1367

Arg Tyr Tyr Asp His Tyr Phe Asp Tyr 
1               5                   


<210>  1368
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 4 (FW4) sequence

<400>  1368
tggggccaag gcaccgctct cacggtctcc tca                                    33


<210>  1369
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 heavy chain variable framework 4 (FW4) sequence

<400>  1369

Trp Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
1               5                   10      


<210>  1370
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 1 (FR1) sequence

<400>  1370
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  1371
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 1 (FR1) sequence

<400>  1371

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1372
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1372
agatctagtc agaccattgt acatagtaat ggaaacacct atttagaa                    48


<210>  1373
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1373

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  1374
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 2 (FR2) sequence

<400>  1374
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  1375
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 2 (FR2) sequence

<400>  1375

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1376
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1376
aaagtttcca accgattttc t                                                 21


<210>  1377
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1377

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1378
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 3 (FR3) sequence

<400>  1378
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agggtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  1379
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 3 (FR3) sequence

<400>  1379

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1380
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1380
tttcaagatt cacatgttcc tctcacg                                           27


<210>  1381
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1381

Phe Gln Asp Ser His Val Pro Leu Thr 
1               5                   


<210>  1382
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 4 (FR4) sequence

<400>  1382
ttcggtgctg ggaccaagct ggagctgaaa                                        30


<210>  1383
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 5C6F3 light chain variable framework 4 (FR4) sequence

<400>  1383

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  1384
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu5C6F3 scFv sequence

<400>  1384
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt acctatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcagcc attagtaatg gtggtggtta cacctactat      180

ccagacagtc tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccacgt attactgtgc aagacgttac      300

tatgatcact actttgacta ctggggccaa ggcaccgctc tcacggtctc ctcaggtggc      360

ggaggatctg gcggaggtgg aagcggcgga ggcggatccg atgttttgat gacccaaact      420

ccactctccc tgcctgtcag tcttggagat caagcctcca tctcttgcag atctagtcag      480

accattgtac atagtaatgg aaacacctat ttagaatggt acctgcagaa accaggccag      540

tctccaaagc tcctgatcta caaagtttcc aaccgatttt ctggggtccc agacaggttc      600

agtggcagtg gatcagggac agatttcaca ctcaagatca gcagggtgga ggctgaggat      660

ctgggagttt attactgctt tcaagattca catgttcctc tcacgttcgg tgctgggacc      720

aagctggagc tgaaa                                                       735


<210>  1385
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu5C6F3 scFv sequence

<400>  1385

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Asp His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu 
    130                 135                 140                 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Asp Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Leu Lys 
                245 


<210>  1386
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 1 (CDR1) sequence

<400>  1386
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggaat cactttcagt                                        90


<210>  1387
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 1 (CDR1) sequence

<400>  1387

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser 
            20                  25                  30  


<210>  1388
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1388
acctatacca tgtcg                                                        15


<210>  1389
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1389

Thr Tyr Thr Met Ser 
1               5   


<210>  1390
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 2 (CDR2) sequence

<400>  1390
tgggttcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  1391
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 2 (CDR2) sequence

<400>  1391

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1392
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1392
accattagta ctggtggtga taaaacctac tattcagaca gtgtgaaggg t                51


<210>  1393
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1393

Thr Ile Ser Thr Gly Gly Asp Lys Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  1394
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 3 (CDR3) sequence

<400>  1394
cgattcacca tctccagaga caatgccaag aacaacctgt acctccaaat gagcagtctg       60

aggtctgagg acacggcctt gtattactgt gcaagg                                 96


<210>  1395
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 3 (CDR3) sequence

<400>  1395

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1396
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1396
ggaaccacgg ctatgtatta ctatgctatg gactac                                 36


<210>  1397
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1397

Gly Thr Thr Ala Met Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  1398
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 4 (CDR4) sequence

<400>  1398
tggggtcaag gaacctcagt caccgtctcc tca                                    33


<210>  1399
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 heavy chain variable framework 4 (CDR4) sequence

<400>  1399

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  1400
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 1 (FW1) sequence

<400>  1400
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgc                                                               69


<210>  1401
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 1 (FW1) sequence

<400>  1401

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  1402
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1402
agggccagca aaagtatcag tacatctgac tataattata ttcac                       45


<210>  1403
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1403

Arg Ala Ser Lys Ser Ile Ser Thr Ser Asp Tyr Asn Tyr Ile His 
1               5                   10                  15  


<210>  1404
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 2 (FW2) sequence

<400>  1404
tggtaccaac agaaaccagg acagccaccc aaactcctca tctat                       45


<210>  1405
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 2 (FW2) sequence

<400>  1405

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1406
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1406
cttgcatcca acctagaatc t                                                 21


<210>  1407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1407

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  1408
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 3 (FW3) sequence

<400>  1408
gggtccctgc caggttcagt ggcagtgggt ctgggacaga cttcaccctc aacatccatc       60

ctgtggagga agaagatgct gcaacctatt actgt                                  95


<210>  1409
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 3 (FW3) sequence

<400>  1409

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1410
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1410
cagcacagta gggagcttcc tctcacg                                           27


<210>  1411
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1411

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  1412
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 4 (FW4) sequence

<400>  1412
ttcggtgctg ggaccaagct ggagctgaaa                                        30


<210>  1413
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 3C2B1 light chain variable framework 4 (FW4) sequence

<400>  1413

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  1414
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 1 (FW1) sequence

<400>  1414
caggcgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaacc                                        90


<210>  1415
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 1 (FW1) sequence

<400>  1415

Gln Ala Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  1416
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1416
agctatggtg tacac                                                        15


<210>  1417
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1417

Ser Tyr Gly Val His 
1               5   


<210>  1418
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 2 (FW2) sequence

<400>  1418
tgggttcgcc agcctccagg aaagggtctg gagtggctgg ga                          42


<210>  1419
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 2 (FW2) sequence

<400>  1419

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  1420
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1420
gtaatatggc ctggtggaag cacaaattat aattcgactc tcatgtccag aatg             54


<210>  1421
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1421

Val Ile Trp Pro Gly Gly Ser Thr Asn Tyr Asn Ser Thr Leu Met Ser 
1               5                   10                  15      


Arg Met 
        


<210>  1422
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 3 (FW3) sequence

<400>  1422
cggatcatca aagacaactc caagagccaa gttttcttaa aaatgaacag tctgcaaatt       60

gatgacacag ccatgtacta ctgtgccaga                                        90


<210>  1423
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 3 (FW3) sequence

<400>  1423

Arg Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
1               5                   10                  15      


Ser Leu Gln Ile Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30  


<210>  1424
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1424
gatcggacac ctcgggtggg ggcctggttt gcttac                                 36


<210>  1425
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1425

Asp Arg Thr Pro Arg Val Gly Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  1426
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 4 (FW4) sequence

<400>  1426
tggggccaag ggactctggt cactgtctct gcag                                   34


<210>  1427
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 heavy chain variable framework 4 (FW4) sequence

<400>  1427

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  1428
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 1 (FR1) sequence

<400>  1428
atcattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgc                                                               69


<210>  1429
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 1 (FR1) sequence

<400>  1429

Ile Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  1430
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1430
agagccagtg agagtgttgc tacttatggc aataatttta tgcag                       45


<210>  1431
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1431

Arg Ala Ser Glu Ser Val Ala Thr Tyr Gly Asn Asn Phe Met Gln 
1               5                   10                  15  


<210>  1432
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 1 (FW1) sequence

<400>  1432
gaagtggtgc tggtggagtc tgggggaggc ttagtggagc ctggagggtc cctgaaactc       60

tcctgtgtag cctctggatt cgctttcagt                                        90


<210>  1433
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 1 (FW1) sequence

<400>  1433

Glu Val Val Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30  


<210>  1434
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1434
acctttgcca tgtct                                                        15


<210>  1435
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1435

Thr Phe Ala Met Ser 
1               5   


<210>  1436
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 2 (FW2) sequence

<400>  1436
tggattcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  1437
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 2 (FW2) sequence

<400>  1437

Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1438
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1438
gccattagta atggtggtgg ttacacctac tatccagaca ctctgaaggg g                51


<210>  1439
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1439

Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Thr Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  1440
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 3 (FW3) sequence

<400>  1440
cgattctcca tctccagaga caatgccaag aataccctgt acctgcaaat gagtagtctg       60

aggtctgagg acacggccgt gtattactgt gcaaga                                 96


<210>  1441
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 3 (FW3) sequence

<400>  1441

Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1442
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1442
cgctactatg atctctactt tgactta                                           27


<210>  1443
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1443

Arg Tyr Tyr Asp Leu Tyr Phe Asp Leu 
1               5                   


<210>  1444
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 4 (FW4) sequence

<400>  1444
tggggccgag gcacctctct catagtctcc tca                                    33


<210>  1445
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 heavy chain variable framework 4 (FW4) sequence

<400>  1445

Trp Gly Arg Gly Thr Ser Leu Ile Val Ser Ser 
1               5                   10      


<210>  1446
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 1 (FR1) sequence

<400>  1446
gatattctga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atttcttgc                                                               69


<210>  1447
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 1 (FR1) sequence

<400>  1447

Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1448
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1448
agatctagtc agaacattgt acatagtaat ggaaacacct atttagaa                    48


<210>  1449
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1449

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  1450
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 2 (FR2) sequence

<400>  1450
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  1451
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 2 (FR2) sequence

<400>  1451

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1452
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1452
aaagtttcca accgattttc t                                                 21


<210>  1453
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1453

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1454
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 3 (FR3) sequence

<400>  1454
ggggtccccg acaggttcag tggtagtggg tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  1455
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 3 (FR3) sequence

<400>  1455

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1456
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1456
tttcaagatt cacatgttcc tctcacg                                           27


<210>  1457
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1457

Phe Gln Asp Ser His Val Pro Leu Thr 
1               5                   


<210>  1458
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 4 (FR4) sequence

<400>  1458
ttcggtgctg ggaccaggct ggagctgaaa                                        30


<210>  1459
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B2 light chain variable framework 4 (FR4) sequence

<400>  1459

Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
1               5                   10  


<210>  1460
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 1 (FW1) sequence

<400>  1460
gaggtgcagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  1461
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 1 (FW1) sequence

<400>  1461

Glu Val Gln Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1462
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1462
agatatggca tgtct                                                        15


<210>  1463
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1463

Arg Tyr Gly Met Ser 
1               5   


<210>  1464
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 2 (FW2) sequence

<400>  1464
tgggttcgcc agactccaga caagaggctg gagtgggtcg ca                          42


<210>  1465
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 2 (FW2) sequence

<400>  1465

Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1466
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1466
accattagta gtggtggtac ttacatctac tatccagaca gtgtgaaggg g                51


<210>  1467
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1467

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  1468
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 3 (FW3) sequence

<400>  1468
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aagtctgagg acacagccat gtattactgt gcaagg                                 96


<210>  1469
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 3 (FW3) sequence

<400>  1469

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1470
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1470
gataactacg gtagtagcta cgactatgct atggactac                              39


<210>  1471
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1471

Asp Asn Tyr Gly Ser Ser Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  1472
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 4 (FW4) sequence

<400>  1472
tggggtcaag gaacctcagt caccgtctcc tca                                    33


<210>  1473
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 heavy chain variable framework 4 (FW4) sequence

<400>  1473

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  1474
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 1 (FR1) sequence

<400>  1474
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  1475
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 1 (FR1) sequence

<400>  1475

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1476
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1476
agatctagtc agaccattgt acatagtaat ggaaacacct atttagaa                    48


<210>  1477
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1477

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  1478
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 2 (FR2) sequence

<400>  1478
tggtacctgc aaaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  1479
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 2 (FR2) sequence

<400>  1479

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1480
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1480
aaagtttcca accgattttc t                                                 21


<210>  1481
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1481

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1482
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 3 (FR3) sequence

<400>  1482
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agggtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  1483
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 3 (FR3) sequence

<400>  1483

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1484
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1484
tttcaagatt cacatgttcc tctcacg                                           27


<210>  1485
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1485

Phe Gln Asp Ser His Val Pro Leu Thr 
1               5                   


<210>  1486
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 4 (FR4) sequence

<400>  1486
ttcggtgctg ggaccaagct ggagctgaaa                                        30


<210>  1487
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B7 light chain variable framework 4 (FR4) sequence

<400>  1487

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  1488
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 1 (FW1) sequence

<400>  1488
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  1489
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 1 (FW1) sequence

<400>  1489

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1490
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1490
acctatgcca tgtct                                                        15


<210>  1491
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1491

Thr Tyr Ala Met Ser 
1               5   


<210>  1492
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 2 (FW2) sequence

<400>  1492
tgggttcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  1493
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 2 (FW2) sequence

<400>  1493

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1494
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1494
gccattagta atggtggtgg ttacacctac tatccagaca gtctgaaggg g                51


<210>  1495
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1495

Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  1496
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 3 (FW3) sequence

<400>  1496
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aggtctgagg acacggccac gtattactgt gcaaga                                 96


<210>  1497
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 3 (FW3) sequence

<400>  1497

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1498
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1498
cgttactatg atcactactt tgactac                                           27


<210>  1499
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1499

Arg Tyr Tyr Asp His Tyr Phe Asp Tyr 
1               5                   


<210>  1500
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 4 (FW4) sequence

<400>  1500
tggggccaag gcaccgctct cacggtctcc tca                                    33


<210>  1501
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 heavy chain variable framework 4 (FW4) sequence

<400>  1501

Trp Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
1               5                   10      


<210>  1502
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 1 (FR1) sequence

<400>  1502
atcattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgc                                                               69


<210>  1503
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 1 (FR1) sequence

<400>  1503

Ile Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  1504
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1504
agagccagtg agagtgttgc tacttatggc aataatttta tgcag                       45


<210>  1505
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1505

Arg Ala Ser Glu Ser Val Ala Thr Tyr Gly Asn Asn Phe Met Gln 
1               5                   10                  15  


<210>  1506
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 2 (FR2) sequence

<400>  1506
tggtatcagc agaaaccagg acagccaccc aaactcctca tctat                       45


<210>  1507
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 2 (FR2) sequence

<400>  1507

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1508
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1508
cttgcatcca ccctagattc t                                                 21


<210>  1509
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1509

Leu Ala Ser Thr Leu Asp Ser 
1               5           


<210>  1510
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 3 (FR3) sequence

<400>  1510
ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat       60

cctgtggagg ctgatgatgc tgcaacctat tactgt                                 96


<210>  1511
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 3 (FR3) sequence

<400>  1511

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1512
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1512
cagcaaaata atgaggatcc tccgacg                                           27


<210>  1513
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1513

Gln Gln Asn Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  1514
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 4 (FR4) sequence

<400>  1514
ttcggtggag gcaccaagct ggaaatcaag                                        30


<210>  1515
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse 8C7F3 light chain variable framework 4 (FR4) sequence

<400>  1515

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1516
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 1 (FW1) sequence

<400>  1516
gaagtggtgc tggtggagtc tgggggaggc ttagtggagc ctggagggtc cctgaaactc       60

tcctgtgtag cctctggatt cgcttttagt                                        90


<210>  1517
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 1 (FW1) sequence

<400>  1517

Glu Val Val Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30  


<210>  1518
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1518
acctttgcca tgtct                                                        15


<210>  1519
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1519

Thr Phe Ala Met Ser 
1               5   


<210>  1520
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 2 (FW2) sequence

<400>  1520
tggattcgcc agactccgga gaagaggctg gagtgggtcg ca                          42


<210>  1521
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 2 (FW2) sequence

<400>  1521

Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1522
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1522
gccattagta atggtggtgg ttacacttac tatccagaca ctctgaaggg g                51


<210>  1523
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1523

Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Thr Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  1524
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 3 (FW3) sequence

<400>  1524
cgattcacca tctccagaga caatgccaag aataccctgt acctgcaaat gagtagtctg       60

aggtctgagg acacggccgt gtattactgt gcaaga                                 96


<210>  1525
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 3 (FW3) sequence

<400>  1525

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1526
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1526
cgctactatg atctctactt tgactta                                           27


<210>  1527
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1527

Arg Tyr Tyr Asp Leu Tyr Phe Asp Leu 
1               5                   


<210>  1528
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 4 (FW4) sequence

<400>  1528
tggggccaag gcacctctct catagtctcc tca                                    33


<210>  1529
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 heavy chain variable framework 4 (FW4) sequence

<400>  1529

Trp Gly Gln Gly Thr Ser Leu Ile Val Ser Ser 
1               5                   10      


<210>  1530
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 1 (FR1) sequence

<400>  1530
gatattctga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atttcttgc                                                               69


<210>  1531
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 1 (FR1) sequence

<400>  1531

Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  1532
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1532
agatctagtc agaacattgt acatagtaat ggaaacacct atttagaa                    48


<210>  1533
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable complementarity determining 
       regions 1 (CDR1) sequence

<400>  1533

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  1534
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 2 (FR2) sequence

<400>  1534
tggtacctgc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  1535
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 2 (FR2) sequence

<400>  1535

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1536
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1536
aaagtttcca accgattttc t                                                 21


<210>  1537
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1537

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  1538
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 3 (FR3) sequence

<400>  1538
ggggtccccg acaggttcag tggtagtggg tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggagtttat tactgc                                 96


<210>  1539
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 3 (FR3) sequence

<400>  1539

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  1540
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1540
tttcaagatt cacatgttcc tctcacg                                           27


<210>  1541
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1541

Phe Gln Asp Ser His Val Pro Leu Thr 
1               5                   


<210>  1542
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 4 (FR4) sequence

<400>  1542
ttcggtgctg ggaccaggct ggagctgaaa                                        30


<210>  1543
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse H11 light chain variable framework 4 (FR4) sequence

<400>  1543

Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
1               5                   10  


<210>  1544
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 1 (FW1) sequence

<400>  1544
gaggtgcagg tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt                                        90


<210>  1545
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 1 (FW1) sequence

<400>  1545

Glu Val Gln Val Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  1546
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1546
agatatggca tgtct                                                        15


<210>  1547
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1547

Arg Tyr Gly Met Ser 
1               5   


<210>  1548
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 2 (FW2) sequence

<400>  1548
tgggttcgcc agactccaga caagaggctg gagtgggtcg ca                          42


<210>  1549
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 2 (FW2) sequence

<400>  1549

Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  1550
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1550
accattagta gtggtggtac ttacatctac tatccagaca gtgtgaaggg g                51


<210>  1551
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1551

Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  1552
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 3 (FW3) sequence

<400>  1552
cgattcacca tctccagaga caatgccaag aacaccctgt acctgcaaat gagcagtctg       60

aagtctgagg acacagccat gtattactgt gca                                    93


<210>  1553
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 3 (FW3) sequence

<400>  1553

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  1554
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1554
agggataact acggtagtag ctacgactat gctatggact ac                          42


<210>  1555
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1555

Asp Asn Tyr Gly Ser Ser Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  1556
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 4 (FW4) sequence

<400>  1556
tggggtcaag gaacctcagt caccgtctcc tct                                    33


<210>  1557
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 heavy chain variable framework 4 (FW4) sequence

<400>  1557

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  1558
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 1 (FR1) sequence

<400>  1558
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga ggaggtcacc       60

ctaacctgc                                                               69


<210>  1559
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 1 (FR1) sequence

<400>  1559

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Glu Val Thr Leu Thr Cys 
            20              


<210>  1560
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1560
agtgccagct caagtgtaag ttacatgcac                                        30


<210>  1561
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable complementarity determining regions
       1 (CDR1) sequence

<400>  1561

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  1562
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 2 (FR2) sequence

<400>  1562
tggttccagc agaggccagg cacttctccc aaactctgga tttat                       45


<210>  1563
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 2 (FR2) sequence

<400>  1563

Trp Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  


<210>  1564
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1564
accacatcca acctggcttc t                                                 21


<210>  1565
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable complementarity determining regions
       2 (CDR2) sequence

<400>  1565

Thr Thr Ser Asn Leu Ala Ser 
1               5           


<210>  1566
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 3 (FR3) sequence

<400>  1566
ggagtccctg ctcgcttcag tggcagtgga tctgggacct cttactctct cacaatcagc       60

cgaatggagg ctgaagatgc tgccacttat tactgc                                 96


<210>  1567
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 3 (FR3) sequence

<400>  1567

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1568
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1568
cagcaaagga gtagttaccc attc                                              24


<210>  1569
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable complementarity determining regions
       3 (CDR3) sequence

<400>  1569

Gln Gln Arg Ser Ser Tyr Pro Phe 
1               5               


<210>  1570
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 4 (FR4) sequence

<400>  1570
acgttcggct cggggacaaa gttggaaata aaa                                    33


<210>  1571
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B9 light chain variable framework 4 (FR4) sequence

<400>  1571

Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10      


<210>  1572
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu3C2B1 scFv sequence

<400>  1572
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggaat cactttcagt acctatacca tgtcgtgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtactg gtggtgataa aacctactat      180

tcagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caacctgtac      240

ctccaaatga gcagtctgag gtctgaggac acggccttgt attactgtgc aaggggaacc      300

acggctatgt attactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tcaggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccga cattgtgctg      420

acacagtctc ctgcttcctt agctgtatct ctggggcaga gggccaccat ctcatgcagg      480

gccagcaaaa gtatcagtac atctgactat aattatattc actggtacca acagaaacca      540

ggacagccac ccaaactcct catctatctt gcatccaacc tagaatctgg ggtccctgcc      600

aggttcagtg gcagtgggtc tgggacagac ttcaccctca acatccatcc tgtggaggaa      660

gaagatgctg caacctatta ctgtcagcac agtagggagc ttcctctcac gttcggtgct      720

gggaccaagc tggagctgaa a                                                741


<210>  1573
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu3C2B1 scFv sequence

<400>  1573

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Gly Asp Lys Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Met Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Ile Ser Thr Ser Asp Tyr Asn Tyr Ile His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Leu Thr Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Leu Lys 
                245         


<210>  1574
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10 scFv full sequence

<400>  1574
gaagtgatgc tggtggaatc tggcggcgga ctggttaagc ctggcggatc tctgaagctg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat ccggcagacc      120

cctgagaaga gactggaatg ggttgccagc atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg tgcggaacat cctgtacctg      240

cagatgagca gcctgcggag cgaggatacc gccatgtact actgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggttac agtttctgct      360

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccaatat catgatgaca      420

cagagcccca gcagcctggc tgtgtctgct ggcgagaaag tgaccatgtc ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccagt ctcctaagct gctgatctac tgggccagca ccagagaaag cggcgtgccc      600

gatagattca caggcagcgg cagcggaacc gacttcaccc tgacaatcag ctctgtgcag      660

gccgaagatc tggccgtgta ctattgccac cagtacctgt ccagcctgac ctttggcgcc      720

ggaacaaagc tggaactgaa g                                                741


<210>  1575
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10 scFv full sequence

<400>  1575

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Ala 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Leu Lys 
                245         


<210>  1576
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10M scFV

<400>  1576
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgaca      420

cagagccctt ctagcctggc cgtgtctctg ggagagagag ccacaatcag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggacagt ctcccaagct gctgatctac tgggccagca ccagagaaag cggcgtgccc      600

gatagattca caggctctgg cagcggcacc gacttcaccc tgacaattag cagtctgcag      660

gccgaggacg tggccgtgta ctactgtcac cagtacctga gcagcctgac ctttggcggc      720

ggaacaaagg tggaaatcaa g                                                741


<210>  1577
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10M scFV

<400>  1577

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  1578
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10C2 scFV

<400>  1578
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat tgtgctgacc      420

cagtctccag cctccttggc cgtgtctcca ggacagaggg ccaccatcac ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaaa      540

ccaggacaac ctcctaaact cctgatttac tgggccagca ccagagaaag cggggtccca      600

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      660

gctaatgata ctgcaaatta ttactgtcac cagtacctga gcagcctgac cttcggcgga      720

gggaccaagg tggagatcaa acga                                             744


<210>  1579
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10C2 scFV

<400>  1579

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr 
    210                 215                 220                 


Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg 
                245             


<210>  1580
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10N scFV

<400>  1580
caggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtggcgtct attggcagag ccggcagcac ctactacagc      180

gactctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtttctagc      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgaaat tgtgctgaca      420

cagagccccg ccacactgtc actttctcca ggcgaaagag ccacactgag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccaag ctcctcggct gctgatctat tgggccagca caagagagag cggcatccct      600

gccagatttt ctggcagcgg ctctggcacc gatttcaccc tgaccataag cagcctggaa      660

cctgaggact tcgccgtgta ttactgccac cagtacctga gcagcctgac ctttggcgga      720

ggcaccaagg tggaaatcaa gcgg                                             744


<210>  1581
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10N scFV

<400>  1581

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg 
                245             


<210>  1582
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T841BB3z

<400>  1582
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1583
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T841BB3z

<400>  1583

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  1584
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T841BB3z

<400>  1584
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  1585
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T841BB3z

<400>  1585

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  1586
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T8283z

<400>  1586
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag     1020

aggagcaggc tcctgcacag tgactacatg aacatgactc ctagaagacc tgggcctacc     1080

agaaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataa                               1476


<210>  1587
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T8283z

<400>  1587

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  1588
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T8283z

<400>  1588
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1589
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T8283z

<400>  1589

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  1590
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T841BB3z1XX

<400>  1590
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1591
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T841BB3z1XX

<400>  1591

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  1592
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T841BB3z1XX

<400>  1592
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat     1320

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc     1440

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  1593
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T841BB3z1XX

<400>  1593

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  1594
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T8283z1XX

<400>  1594
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag     1020

aggagcaggc tcctgcacag tgactacatg aacatgactc ctagaagacc tgggcctacc     1080

agaaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgtt caatgaactg     1320

cagaaagata agatggcgga ggccttcagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct tttccagggt ctcagtacag ccaccaagga caccttcgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataa                               1476


<210>  1595
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10CAR T8283z1XX

<400>  1595

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  1596
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T8283z1XX

<400>  1596
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1597
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10CAR T8283z1XX

<400>  1597

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            340                 345                 350         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        355                 360                 365             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  1598
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6 scFv full sequence

<400>  1598
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggttt cactttcagt agttatggaa tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtaatg gtggtagaca caccttctat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtat      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt atttatgtgt aagacagact      300

gggacggagg gctggtttgc ttactggggc caagggactc tggtcactgt ctctgcaggt      360

ggcggaggat ctggcggagg tggaagcggc ggaggcggat ccgatgttgt gatgacccag      420

actccactca ctttgtcggt taccattgga caaccagcct ccatctcttg caagtcaagt      480

cagagcctct tagatagtga tggaaagaca tatttgaatt ggttgttaca gaggccaggc      540

cagtctccaa agcgcctaat ctatctggtg tctaaactgg actctggagt ccctgacagg      600

ttcactggca gtggatcagg gacagatttc acactgaaaa tcagcagagt ggaggctgag      660

gatttgggag tttattattg ctggcaaggt acacattttc ctcagacgtt cggtggaggc      720

accaagctgg aaatcaaa                                                    738


<210>  1599
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6 scFv full sequence

<400>  1599

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Leu Cys 
                85                  90                  95      


Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Thr 
    130                 135                 140                 


Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu 
                165                 170                 175     


Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys 
            180                 185                 190         


Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  1600
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6 full sequence

<400>  1600
gaggtgcagc tggtggaatc tggcggagga ctggtcaagc ctggaggcag cctgagactg       60

agctgcgccg ccagcggctt cacattcagc agctacggca tgagctgggt gcggcaggcc      120

cctggcaagg gcctggaatg ggtcagcacc atcagcaacg gcggaagaca caccttctac      180

cccgacagcg tgaagggcag attcaccatc tcaagagata acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagacagacc      300

ggcacagagg gctggttcgc ctactggggc cagggcaccc tggtgaccgt gtccagcggc      360

ggtggcggaa gcggaggcgg tggctccggt ggcggaggca gcgacatcgt gatgacccag      420

acccctctgt ctctgagcgt gacccctggc cagcctgcca gcatctcttg taaaagcagc      480

cagagcctgc tggacagcga cggcaagacc tacctgaact ggtacctgca gaagcccggc      540

caaagccctc agctgctgat ctacctggtg tccaagctgg atagcggtgt tcctgataga      600

ttcagcggat ctggcagcgg caccgacttc accctgaaga tcagcagagt ggaagccgag      660

gacgtgggcg tgtactactg ctggcagggc acacacttcc cccagacatt cggccagggc      720

accaaggtgg aaatcaag                                                    738


<210>  1601
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6 full sequence

<400>  1601

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Lys 
            180                 185                 190         


Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  1602
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T841BB3z

<400>  1602
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataa                               1476


<210>  1603
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T841BB3z

<400>  1603

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  1604
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T841BB3z

<400>  1604
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataa                               1476


<210>  1605
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T841BB3z

<400>  1605

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  1606
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T8283z

<400>  1606
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taa                                  1473


<210>  1607
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T8283z

<400>  1607

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  1608
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T8283z

<400>  1608
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taa                                  1473


<210>  1609
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T8283z

<400>  1609

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  1610
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T841BB3z1XX

<400>  1610
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgtt caatgaactg     1320

cagaaagata agatggcgga ggccttcagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct tttccagggt ctcagtacag ccaccaagga caccttcgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataa                               1476


<210>  1611
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T841BB3z1XX

<400>  1611

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  1612
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T841BB3z1XX

<400>  1612
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgtt caatgaactg     1320

cagaaagata agatggcgga ggccttcagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct tttccagggt ctcagtacag ccaccaagga caccttcgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataa                               1476


<210>  1613
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T841BB3z1XX

<400>  1613

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  1614
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T8283z1XX

<400>  1614
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgttcaa tgaactgcag     1320

aaagataaga tggcggaggc cttcagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac cttcgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taa                                  1473


<210>  1615
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6CAR T8283z1XX

<400>  1615

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  1616
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T8283z1XX

<400>  1616
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgttcaa tgaactgcag     1320

aaagataaga tggcggaggc cttcagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac cttcgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taa                                  1473


<210>  1617
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6CAR T8283z1XX

<400>  1617

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  1618
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MNC21XX - muMNC2CAR T841BB3z1XX

<400>  1618
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccac aacaacccct gcccccagac ctcctacccc agcccctaca      900

attgccagcc agcctctgag cctgaggccc gaggcttgta gacctgctgc tggcggagcc      960

gtgcacacca gaggactgga tttcgcctgc gacatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1200

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgttcaa tgaactgcag     1380

aaagataaga tggcggaggc cttcagtgag attgggatga aaggcgagcg ccggaggggc     1440

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac cttcgacgcc     1500

cttcacatgc aggccctgcc ccctcgctga taa                                  1533


<210>  1619
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MNC21XX - muMNC2CAR T841BB3z1XX

<400>  1619

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Val Ile Thr Gln Ser Thr Ala Ser 
                165                 170                 175     


Leu Gly Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            180                 185                 190         


Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln 
        195                 200                 205             


Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
    210                 215                 220                 


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr 
                245                 250                 255     


Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  1620
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2CAR T841BB3z1XX

<400>  1620
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgttc     1320

aatgaactgc agaaagataa gatggcggag gccttcagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt ttccagggtc tcagtacagc caccaaggac     1440

accttcgacg cccttcacat gcaggccctg ccccctcgct gataa                     1485


<210>  1621
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNC2CAR T841BB3z1XX

<400>  1621

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  1622
<211>  1530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNC2CAR T8283z1XX

<400>  1622
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccac aacaacccct gcccccagac ctcctacccc agcccctaca      900

attgccagcc agcctctgag cctgaggccc gaggcttgta gacctgctgc tggcggagcc      960

gtgcacacca gaggactgga tttcgcctgc gacatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaggag taagaggagc     1080

aggctcctgc acagtgacta catgaacatg actcctagaa gacctgggcc taccagaaag     1140

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1200

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1260

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1320

atggggggaa agccgagaag gaagaaccct caggaaggcc tgttcaatga actgcagaaa     1380

gataagatgg cggaggcctt cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1440

gggcacgatg gccttttcca gggtctcagt acagccacca aggacacctt cgacgccctt     1500

cacatgcagg ccctgccccc tcgctgataa                                      1530


<210>  1623
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMNC2CAR T8283z1XX

<400>  1623

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Val Ile Thr Gln Ser Thr Ala Ser 
                165                 170                 175     


Leu Gly Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            180                 185                 190         


Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln 
        195                 200                 205             


Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
    210                 215                 220                 


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr 
                245                 250                 255     


Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                325                 330                 335     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            340                 345                 350         


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        355                 360                 365             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    370                 375                 380                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  1624
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2CAR T8283z1XX

<400>  1624
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactcctag aagacctggg     1080

cctaccagaa agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat     1320

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc     1440

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  1625
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNC2CAR T8283z1XX

<400>  1625

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  1626
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MNE61XX - muMNE6CAR T841BB3z1XX

<400>  1626
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt tcaatgaact gcagaaagat     1320

aagatggcgg aggccttcag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc ttttccaggg tctcagtaca gccaccaagg acaccttcga cgcccttcac     1440

atgcaggccc tgccccctcg ctgataa                                         1467


<210>  1627
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MNE61XX - muMNE6CAR T841BB3z1XX

<400>  1627

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr His Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Glu 
                165                 170                 175     


Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  1628
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6CAR T841BB3z1XX

<400>  1628
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt tcaatgaact gcagaaagat     1320

aagatggcgg aggccttcag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc ttttccaggg tctcagtaca gccaccaagg acaccttcga cgcccttcac     1440

atgcaggccc tgccccctcg ctgataa                                         1467


<210>  1629
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNE6CAR T841BB3z1XX

<400>  1629

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  1630
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE6CAR T84283z1XX

<400>  1630
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactcct agaagacctg ggcctaccag aaagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgttca atgaactgca gaaagataag     1320

atggcggagg ccttcagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt tccagggtct cagtacagcc accaaggaca ccttcgacgc ccttcacatg     1440

caggccctgc cccctcgctg ataa                                            1464


<210>  1631
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMNE6CAR T84283z1XX

<400>  1631

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr His Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Glu 
                165                 170                 175     


Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1632
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6CAR T84283z1XX

<400>  1632
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactcct agaagacctg ggcctaccag aaagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgttca atgaactgca gaaagataag     1320

atggcggagg ccttcagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt tccagggtct cagtacagcc accaaggaca ccttcgacgc ccttcacatg     1440

caggccctgc cccctcgctg ataa                                            1464


<210>  1633
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNE6CAR T84283z1XX

<400>  1633

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys 
                325                 330                 335     


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
            340                 345                 350         


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
        355                 360                 365             


Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1634
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal CMV promoter (mCMV)

<400>  1634
taggcgtgta cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc       60

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccag         117


<210>  1635
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal IL2 promoter (mIL2P)

<400>  1635
cattttgaca cccccataat atttttccag aattaacagt ataaattgca tctcttgttc       60

aagagttccc tatcactctc tttaatcact actcacagta acctcaactc ctgc            114


<210>  1636
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal promoter, miniP

<400>  1636
agagggtata taatggaagc tcgacttcca g                                      31


<210>  1637
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL18 activated

<400>  1637
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa cgaccaggtg      120

ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag cgactgcaga      180

gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca gcctagaggc      240

atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg cgagaacaag      300

atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa gagcgacatc      360

atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga gagcagcagc      420

tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct gatcctgaag      480

aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga ggactgataa      540


<210>  1638
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18 activated

<400>  1638

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val 
            20                  25                  30          


Ile Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg 
        35                  40                  45              


Pro Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro 
    50                  55                  60                  


Arg Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly 
65                  70                  75                  80  


Met Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser 
                85                  90                  95      


Cys Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn 
            100                 105                 110         


Ile Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro 
        115                 120                 125             


Gly His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr 
    130                 135                 140                 


Phe Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys 
145                 150                 155                 160 


Lys Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn 
                165                 170                 175     


Glu Asp 
        


<210>  1639
<211>  770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foxp3NFATc1X3IL18

<400>  1639
ggcttcattt tttccattta ctgcagaggc ttcatttttt ccatttactg cagaggcttc       60

attttttcca tttactgcag aactagttag gcgtgtacgg tgggaggcct atataagcag      120

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      180

tagaagacac cgggaccgat ccagcctcga gagacccaat gctagccacc atggccttac      240

cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccgtacttcg      300

gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa cgaccaggtg ctgttcatcg      360

atcagggcaa cagacccctg ttcgaggaca tgaccgacag cgactgcaga gacaacgccc      420

ctcggaccat cttcatcatc agcatgtaca aggacagcca gcctagaggc atggccgtga      480

ccatctctgt gaagtgcgag aagatcagca ccctgagctg cgagaacaag atcatcagct      540

tcaaagagat gaacccgccg gacaacatca aggacaccaa gagcgacatc atattcttcc      600

agcggagcgt gcccggccac gacaacaaga tgcagtttga gagcagcagc tacgagggct      660

acttcctggc ctgcgagaaa gagcgggacc tgttcaagct gatcctgaag aaagaggacg      720

aactgggcga ccgcagcatc atgttcaccg tgcagaacga ggactgataa                 770


<210>  1640
<211>  850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foxp3NFATc1X6IL18

<400>  1640
gcttcatttt ttccatttac tgcagaggct tcattttttc catttactgc agaggcttca       60

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaggc ttcatttttt      120

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg      180

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat      240

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat      300

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca      360

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa      420

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag      480

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca      540

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg      600

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa      660

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga      720

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct      780

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga      840

ggactgataa                                                             850


<210>  1641
<211>  779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2NFATc1X3IL18

<400>  1641
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt actagttagg cgtgtacggt gggaggccta      120

tataagcaga gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt      180

tgacctccat agaagacacc gggaccgatc cagcctcgag agacccaatg ctagccacca      240

tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc      300

cgtacttcgg caagctggaa agcaagctga gcgtgatccg gaacctgaac gaccaggtgc      360

tgttcatcga tcagggcaac agacccctgt tcgaggacat gaccgacagc gactgcagag      420

acaacgcccc tcggaccatc ttcatcatca gcatgtacaa ggacagccag cctagaggca      480

tggccgtgac catctctgtg aagtgcgaga agatcagcac cctgagctgc gagaacaaga      540

tcatcagctt caaagagatg aacccgccgg acaacatcaa ggacaccaag agcgacatca      600

tattcttcca gcggagcgtg cccggccacg acaacaagat gcagtttgag agcagcagct      660

acgagggcta cttcctggcc tgcgagaaag agcgggacct gttcaagctg atcctgaaga      720

aagaggacga actgggcgac cgcagcatca tgttcaccgt gcagaacgag gactgataa       779


<210>  1642
<211>  868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2NFATc1X6IL18

<400>  1642
ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt       60

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      120

ggaggaaaaa ctgtttcata cagaaggcgt ggaggaaaaa ctgtttcata cagaaggcgt      180

actagttagg cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca      240

gatcgcctgg agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc      300

cagctcgaga gacccaatgc tagccaccat ggccttacca gtgaccgcct tgctcctgcc      360

gctggccttg ctgctccacg ccgccaggcc gtacttcggc aagctggaaa gcaagctgag      420

cgtgatccgg aacctgaacg accaggtgct gttcatcgat cagggcaaca gacccctgtt      480

cgaggacatg accgacagcg actgcagaga caacgcccct cggaccatct tcatcatcag      540

catgtacaag gacagccagc ctagaggcat ggccgtgacc atctctgtga agtgcgagaa      600

gatcagcacc ctgagctgcg agaacaagat catcagcttc aaagagatga acccgccgga      660

caacatcaag gacaccaaga gcgacatcat attcttccag cggagcgtgc ccggccacga      720

caacaagatg cagtttgaga gcagcagcta cgagggctac ttcctggcct gcgagaaaga      780

gcgggacctg ttcaagctga tcctgaagaa agaggacgaa ctgggcgacc gcagcatcat      840

gttcaccgtg cagaacgagg actgataa                                         868


<210>  1643
<211>  2347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Best antibodies with inducible IL18 +/ 1XX mutations in ITAMs of 
       CD3zeta - MNC2 - muMNC2841BB3zFoxp3NFATIL18

<400>  1643
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccac aacaacccct gcccccagac ctcctacccc agcccctaca      900

attgccagcc agcctctgag cctgaggccc gaggcttgta gacctgctgc tggcggagcc      960

gtgcacacca gaggactgga tttcgcctgc gacatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1200

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1380

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1440

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1500

cttcacatgc aggccctgcc ccctcgctga taagtttaaa ctgccagaac atttctctgg     1560

cctaactggc cggtaccggc ttcatttttt ccatttactg cagaggcttc attttttcca     1620

tttactgcag aggcttcatt ttttccattt actgcagaac tagttaggcg tgtacggtgg     1680

gaggcctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     1740

cgctgttttg acctccatag aagacaccgg gaccgatcca gcctcgagag acccaatgct     1800

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     1860

cgccaggccg tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga     1920

ccaggtgctg ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga     1980

ctgcagagac aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc     2040

tagaggcatg gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga     2100

gaacaagatc atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag     2160

cgacatcata ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag     2220

cagcagctac gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat     2280

cctgaagaaa gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga     2340

ctgataa                                                               2347


<210>  1644
<211>  2299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2841BB3zFoxp3NFATIL18

<400>  1644
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct gataagttta aactgccaga     1500

acatttctct ggcctaactg gccggtaccg gcttcatttt ttccatttac tgcagaggct     1560

tcattttttc catttactgc agaggcttca ttttttccat ttactgcaga actagttagg     1620

cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg     1680

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctcgag     1740

agacccaatg ctagccacca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt     1800

gctgctccac gccgccaggc cgtacttcgg caagctggaa agcaagctga gcgtgatccg     1860

gaacctgaac gaccaggtgc tgttcatcga tcagggcaac agacccctgt tcgaggacat     1920

gaccgacagc gactgcagag acaacgcccc tcggaccatc ttcatcatca gcatgtacaa     1980

ggacagccag cctagaggca tggccgtgac catctctgtg aagtgcgaga agatcagcac     2040

cctgagctgc gagaacaaga tcatcagctt caaagagatg aacccgccgg acaacatcaa     2100

ggacaccaag agcgacatca tattcttcca gcggagcgtg cccggccacg acaacaagat     2160

gcagtttgag agcagcagct acgagggcta cttcctggcc tgcgagaaag agcgggacct     2220

gttcaagctg atcctgaaga aagaggacga actgggcgac cgcagcatca tgttcaccgt     2280

gcagaacgag gactgataa                                                  2299


<210>  1645
<211>  2344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNC28283zFoxp3NFATIL18

<400>  1645
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccac aacaacccct gcccccagac ctcctacccc agcccctaca      900

attgccagcc agcctctgag cctgaggccc gaggcttgta gacctgctgc tggcggagcc      960

gtgcacacca gaggactgga tttcgcctgc gacatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaggag taagaggagc     1080

aggctcctgc acagtgacta catgaacatg actcctagaa gacctgggcc taccagaaag     1140

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1200

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1260

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1320

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1380

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1440

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1500

cacatgcagg ccctgccccc tcgctgataa gtttaaactg ccagaacatt tctctggcct     1560

aactggccgg taccggcttc attttttcca tttactgcag aggcttcatt ttttccattt     1620

actgcagagg cttcattttt tccatttact gcagaactag ttaggcgtgt acggtgggag     1680

gcctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc     1740

tgttttgacc tccatagaag acaccgggac cgatccagcc tcgagagacc caatgctagc     1800

caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc tccacgccgc     1860

caggccgtac ttcggcaagc tggaaagcaa gctgagcgtg atccggaacc tgaacgacca     1920

ggtgctgttc atcgatcagg gcaacagacc cctgttcgag gacatgaccg acagcgactg     1980

cagagacaac gcccctcgga ccatcttcat catcagcatg tacaaggaca gccagcctag     2040

aggcatggcc gtgaccatct ctgtgaagtg cgagaagatc agcaccctga gctgcgagaa     2100

caagatcatc agcttcaaag agatgaaccc gccggacaac atcaaggaca ccaagagcga     2160

catcatattc ttccagcgga gcgtgcccgg ccacgacaac aagatgcagt ttgagagcag     2220

cagctacgag ggctacttcc tggcctgcga gaaagagcgg gacctgttca agctgatcct     2280

gaagaaagag gacgaactgg gcgaccgcag catcatgttc accgtgcaga acgaggactg     2340

ataa                                                                  2344


<210>  1646
<211>  2296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC28283zFoxp3NFATIL18

<400>  1646
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactcctag aagacctggg     1080

cctaccagaa agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aagtttaaac tgccagaaca     1500

tttctctggc ctaactggcc ggtaccggct tcattttttc catttactgc agaggcttca     1560

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaact agttaggcgt     1620

gtacggtggg aggcctatat aagcagagct cgtttagtga accgtcagat cgcctggaga     1680

cgccatccac gctgttttga cctccataga agacaccggg accgatccag cctcgagaga     1740

cccaatgcta gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct     1800

gctccacgcc gccaggccgt acttcggcaa gctggaaagc aagctgagcg tgatccggaa     1860

cctgaacgac caggtgctgt tcatcgatca gggcaacaga cccctgttcg aggacatgac     1920

cgacagcgac tgcagagaca acgcccctcg gaccatcttc atcatcagca tgtacaagga     1980

cagccagcct agaggcatgg ccgtgaccat ctctgtgaag tgcgagaaga tcagcaccct     2040

gagctgcgag aacaagatca tcagcttcaa agagatgaac ccgccggaca acatcaagga     2100

caccaagagc gacatcatat tcttccagcg gagcgtgccc ggccacgaca acaagatgca     2160

gtttgagagc agcagctacg agggctactt cctggcctgc gagaaagagc gggacctgtt     2220

caagctgatc ctgaagaaag aggacgaact gggcgaccgc agcatcatgt tcaccgtgca     2280

gaacgaggac tgataa                                                     2296


<210>  1647
<211>  2347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNC2841BB3z1XXFoxp3NFATIL18

<400>  1647
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccac aacaacccct gcccccagac ctcctacccc agcccctaca      900

attgccagcc agcctctgag cctgaggccc gaggcttgta gacctgctgc tggcggagcc      960

gtgcacacca gaggactgga tttcgcctgc gacatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1080

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1140

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1200

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1260

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1320

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgttcaa tgaactgcag     1380

aaagataaga tggcggaggc cttcagtgag attgggatga aaggcgagcg ccggaggggc     1440

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac cttcgacgcc     1500

cttcacatgc aggccctgcc ccctcgctga taagtttaaa ctgccagaac atttctctgg     1560

cctaactggc cggtaccggc ttcatttttt ccatttactg cagaggcttc attttttcca     1620

tttactgcag aggcttcatt ttttccattt actgcagaac tagttaggcg tgtacggtgg     1680

gaggcctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     1740

cgctgttttg acctccatag aagacaccgg gaccgatcca gcctcgagag acccaatgct     1800

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     1860

cgccaggccg tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga     1920

ccaggtgctg ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga     1980

ctgcagagac aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc     2040

tagaggcatg gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga     2100

gaacaagatc atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag     2160

cgacatcata ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag     2220

cagcagctac gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat     2280

cctgaagaaa gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga     2340

ctgataa                                                               2347


<210>  1648
<211>  2299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2841BB3z1XXFoxp3NFATIL18

<400>  1648
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgttc     1320

aatgaactgc agaaagataa gatggcggag gccttcagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt ttccagggtc tcagtacagc caccaaggac     1440

accttcgacg cccttcacat gcaggccctg ccccctcgct gataagttta aactgccaga     1500

acatttctct ggcctaactg gccggtaccg gcttcatttt ttccatttac tgcagaggct     1560

tcattttttc catttactgc agaggcttca ttttttccat ttactgcaga actagttagg     1620

cgtgtacggt gggaggccta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg     1680

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctcgag     1740

agacccaatg ctagccacca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt     1800

gctgctccac gccgccaggc cgtacttcgg caagctggaa agcaagctga gcgtgatccg     1860

gaacctgaac gaccaggtgc tgttcatcga tcagggcaac agacccctgt tcgaggacat     1920

gaccgacagc gactgcagag acaacgcccc tcggaccatc ttcatcatca gcatgtacaa     1980

ggacagccag cctagaggca tggccgtgac catctctgtg aagtgcgaga agatcagcac     2040

cctgagctgc gagaacaaga tcatcagctt caaagagatg aacccgccgg acaacatcaa     2100

ggacaccaag agcgacatca tattcttcca gcggagcgtg cccggccacg acaacaagat     2160

gcagtttgag agcagcagct acgagggcta cttcctggcc tgcgagaaag agcgggacct     2220

gttcaagctg atcctgaaga aagaggacga actgggcgac cgcagcatca tgttcaccgt     2280

gcagaacgag gactgataa                                                  2299


<210>  1649
<211>  2344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNC28283z1XXFoxp3NFATIL18

<400>  1649
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccac aacaacccct gcccccagac ctcctacccc agcccctaca      900

attgccagcc agcctctgag cctgaggccc gaggcttgta gacctgctgc tggcggagcc      960

gtgcacacca gaggactgga tttcgcctgc gacatctaca tctgggcgcc cttggccggg     1020

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaggag taagaggagc     1080

aggctcctgc acagtgacta catgaacatg actcctagaa gacctgggcc taccagaaag     1140

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1200

agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc     1260

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1320

atggggggaa agccgagaag gaagaaccct caggaaggcc tgttcaatga actgcagaaa     1380

gataagatgg cggaggcctt cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1440

gggcacgatg gccttttcca gggtctcagt acagccacca aggacacctt cgacgccctt     1500

cacatgcagg ccctgccccc tcgctgataa gtttaaactg ccagaacatt tctctggcct     1560

aactggccgg taccggcttc attttttcca tttactgcag aggcttcatt ttttccattt     1620

actgcagagg cttcattttt tccatttact gcagaactag ttaggcgtgt acggtgggag     1680

gcctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc     1740

tgttttgacc tccatagaag acaccgggac cgatccagcc tcgagagacc caatgctagc     1800

caccatggcc ttaccagtga ccgccttgct cctgccgctg gccttgctgc tccacgccgc     1860

caggccgtac ttcggcaagc tggaaagcaa gctgagcgtg atccggaacc tgaacgacca     1920

ggtgctgttc atcgatcagg gcaacagacc cctgttcgag gacatgaccg acagcgactg     1980

cagagacaac gcccctcgga ccatcttcat catcagcatg tacaaggaca gccagcctag     2040

aggcatggcc gtgaccatct ctgtgaagtg cgagaagatc agcaccctga gctgcgagaa     2100

caagatcatc agcttcaaag agatgaaccc gccggacaac atcaaggaca ccaagagcga     2160

catcatattc ttccagcgga gcgtgcccgg ccacgacaac aagatgcagt ttgagagcag     2220

cagctacgag ggctacttcc tggcctgcga gaaagagcgg gacctgttca agctgatcct     2280

gaagaaagag gacgaactgg gcgaccgcag catcatgttc accgtgcaga acgaggactg     2340

ataa                                                                  2344


<210>  1650
<211>  2296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC28283z1XXFoxp3NFATIL18

<400>  1650
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactcctag aagacctggg     1080

cctaccagaa agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat     1320

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc     1440

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aagtttaaac tgccagaaca     1500

tttctctggc ctaactggcc ggtaccggct tcattttttc catttactgc agaggcttca     1560

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaact agttaggcgt     1620

gtacggtggg aggcctatat aagcagagct cgtttagtga accgtcagat cgcctggaga     1680

cgccatccac gctgttttga cctccataga agacaccggg accgatccag cctcgagaga     1740

cccaatgcta gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct     1800

gctccacgcc gccaggccgt acttcggcaa gctggaaagc aagctgagcg tgatccggaa     1860

cctgaacgac caggtgctgt tcatcgatca gggcaacaga cccctgttcg aggacatgac     1920

cgacagcgac tgcagagaca acgcccctcg gaccatcttc atcatcagca tgtacaagga     1980

cagccagcct agaggcatgg ccgtgaccat ctctgtgaag tgcgagaaga tcagcaccct     2040

gagctgcgag aacaagatca tcagcttcaa agagatgaac ccgccggaca acatcaagga     2100

caccaagagc gacatcatat tcttccagcg gagcgtgccc ggccacgaca acaagatgca     2160

gtttgagagc agcagctacg agggctactt cctggcctgc gagaaagagc gggacctgtt     2220

caagctgatc ctgaagaaag aggacgaact gggcgaccgc agcatcatgt tcaccgtgca     2280

gaacgaggac tgataa                                                     2296


<210>  1651
<211>  2281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE6841BB3zFoxp3NFATIL18

<400>  1651
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg ctgataagtt taaactgcca gaacatttct ctggcctaac     1500

tggccggtac cggcttcatt ttttccattt actgcagagg cttcattttt tccatttact     1560

gcagaggctt cattttttcc atttactgca gaactagtta ggcgtgtacg gtgggaggcc     1620

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt     1680

tttgacctcc atagaagaca ccgggaccga tccagcctcg agagacccaa tgctagccac     1740

catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag     1800

gccgtacttc ggcaagctgg aaagcaagct gagcgtgatc cggaacctga acgaccaggt     1860

gctgttcatc gatcagggca acagacccct gttcgaggac atgaccgaca gcgactgcag     1920

agacaacgcc cctcggacca tcttcatcat cagcatgtac aaggacagcc agcctagagg     1980

catggccgtg accatctctg tgaagtgcga gaagatcagc accctgagct gcgagaacaa     2040

gatcatcagc ttcaaagaga tgaacccgcc ggacaacatc aaggacacca agagcgacat     2100

catattcttc cagcggagcg tgcccggcca cgacaacaag atgcagtttg agagcagcag     2160

ctacgagggc tacttcctgg cctgcgagaa agagcgggac ctgttcaagc tgatcctgaa     2220

gaaagaggac gaactgggcg accgcagcat catgttcacc gtgcagaacg aggactgata     2280

a                                                                     2281


<210>  1652
<211>  2281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6841BB3zFoxp3NFATIL18

<400>  1652
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg ctgataagtt taaactgcca gaacatttct ctggcctaac     1500

tggccggtac cggcttcatt ttttccattt actgcagagg cttcattttt tccatttact     1560

gcagaggctt cattttttcc atttactgca gaactagtta ggcgtgtacg gtgggaggcc     1620

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt     1680

tttgacctcc atagaagaca ccgggaccga tccagcctcg agagacccaa tgctagccac     1740

catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag     1800

gccgtacttc ggcaagctgg aaagcaagct gagcgtgatc cggaacctga acgaccaggt     1860

gctgttcatc gatcagggca acagacccct gttcgaggac atgaccgaca gcgactgcag     1920

agacaacgcc cctcggacca tcttcatcat cagcatgtac aaggacagcc agcctagagg     1980

catggccgtg accatctctg tgaagtgcga gaagatcagc accctgagct gcgagaacaa     2040

gatcatcagc ttcaaagaga tgaacccgcc ggacaacatc aaggacacca agagcgacat     2100

catattcttc cagcggagcg tgcccggcca cgacaacaag atgcagtttg agagcagcag     2160

ctacgagggc tacttcctgg cctgcgagaa agagcgggac ctgttcaagc tgatcctgaa     2220

gaaagaggac gaactgggcg accgcagcat catgttcacc gtgcagaacg aggactgata     2280

a                                                                     2281


<210>  1653
<211>  2278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE684283zFoxp3NFATIL18

<400>  1653
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactcct agaagacctg ggcctaccag aaagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgctg ataagtttaa actgccagaa catttctctg gcctaactgg     1500

ccggtaccgg cttcattttt tccatttact gcagaggctt cattttttcc atttactgca     1560

gaggcttcat tttttccatt tactgcagaa ctagttaggc gtgtacggtg ggaggcctat     1620

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt     1680

gacctccata gaagacaccg ggaccgatcc agcctcgaga gacccaatgc tagccaccat     1740

ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc     1800

gtacttcggc aagctggaaa gcaagctgag cgtgatccgg aacctgaacg accaggtgct     1860

gttcatcgat cagggcaaca gacccctgtt cgaggacatg accgacagcg actgcagaga     1920

caacgcccct cggaccatct tcatcatcag catgtacaag gacagccagc ctagaggcat     1980

ggccgtgacc atctctgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat     2040

catcagcttc aaagagatga acccgccgga caacatcaag gacaccaaga gcgacatcat     2100

attcttccag cggagcgtgc ccggccacga caacaagatg cagtttgaga gcagcagcta     2160

cgagggctac ttcctggcct gcgagaaaga gcgggacctg ttcaagctga tcctgaagaa     2220

agaggacgaa ctgggcgacc gcagcatcat gttcaccgtg cagaacgagg actgataa       2278


<210>  1654
<211>  2278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE68283zFoxp3NFATIL18

<400>  1654
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactcct agaagacctg ggcctaccag aaagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgctg ataagtttaa actgccagaa catttctctg gcctaactgg     1500

ccggtaccgg cttcattttt tccatttact gcagaggctt cattttttcc atttactgca     1560

gaggcttcat tttttccatt tactgcagaa ctagttaggc gtgtacggtg ggaggcctat     1620

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt     1680

gacctccata gaagacaccg ggaccgatcc agcctcgaga gacccaatgc tagccaccat     1740

ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc     1800

gtacttcggc aagctggaaa gcaagctgag cgtgatccgg aacctgaacg accaggtgct     1860

gttcatcgat cagggcaaca gacccctgtt cgaggacatg accgacagcg actgcagaga     1920

caacgcccct cggaccatct tcatcatcag catgtacaag gacagccagc ctagaggcat     1980

ggccgtgacc atctctgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat     2040

catcagcttc aaagagatga acccgccgga caacatcaag gacaccaaga gcgacatcat     2100

attcttccag cggagcgtgc ccggccacga caacaagatg cagtttgaga gcagcagcta     2160

cgagggctac ttcctggcct gcgagaaaga gcgggacctg ttcaagctga tcctgaagaa     2220

agaggacgaa ctgggcgacc gcagcatcat gttcaccgtg cagaacgagg actgataa       2278


<210>  1655
<211>  2281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE6841BB3z1XXFoxp3NFATIL18

<400>  1655
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt tcaatgaact gcagaaagat     1320

aagatggcgg aggccttcag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc ttttccaggg tctcagtaca gccaccaagg acaccttcga cgcccttcac     1440

atgcaggccc tgccccctcg ctgataagtt taaactgcca gaacatttct ctggcctaac     1500

tggccggtac cggcttcatt ttttccattt actgcagagg cttcattttt tccatttact     1560

gcagaggctt cattttttcc atttactgca gaactagtta ggcgtgtacg gtgggaggcc     1620

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt     1680

tttgacctcc atagaagaca ccgggaccga tccagcctcg agagacccaa tgctagccac     1740

catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag     1800

gccgtacttc ggcaagctgg aaagcaagct gagcgtgatc cggaacctga acgaccaggt     1860

gctgttcatc gatcagggca acagacccct gttcgaggac atgaccgaca gcgactgcag     1920

agacaacgcc cctcggacca tcttcatcat cagcatgtac aaggacagcc agcctagagg     1980

catggccgtg accatctctg tgaagtgcga gaagatcagc accctgagct gcgagaacaa     2040

gatcatcagc ttcaaagaga tgaacccgcc ggacaacatc aaggacacca agagcgacat     2100

catattcttc cagcggagcg tgcccggcca cgacaacaag atgcagtttg agagcagcag     2160

ctacgagggc tacttcctgg cctgcgagaa agagcgggac ctgttcaagc tgatcctgaa     2220

gaaagaggac gaactgggcg accgcagcat catgttcacc gtgcagaacg aggactgata     2280

a                                                                     2281


<210>  1656
<211>  2281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6841BB3z1XXFoxp3NFATIL18

<400>  1656
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt tcaatgaact gcagaaagat     1320

aagatggcgg aggccttcag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc ttttccaggg tctcagtaca gccaccaagg acaccttcga cgcccttcac     1440

atgcaggccc tgccccctcg ctgataagtt taaactgcca gaacatttct ctggcctaac     1500

tggccggtac cggcttcatt ttttccattt actgcagagg cttcattttt tccatttact     1560

gcagaggctt cattttttcc atttactgca gaactagtta ggcgtgtacg gtgggaggcc     1620

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt     1680

tttgacctcc atagaagaca ccgggaccga tccagcctcg agagacccaa tgctagccac     1740

catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag     1800

gccgtacttc ggcaagctgg aaagcaagct gagcgtgatc cggaacctga acgaccaggt     1860

gctgttcatc gatcagggca acagacccct gttcgaggac atgaccgaca gcgactgcag     1920

agacaacgcc cctcggacca tcttcatcat cagcatgtac aaggacagcc agcctagagg     1980

catggccgtg accatctctg tgaagtgcga gaagatcagc accctgagct gcgagaacaa     2040

gatcatcagc ttcaaagaga tgaacccgcc ggacaacatc aaggacacca agagcgacat     2100

catattcttc cagcggagcg tgcccggcca cgacaacaag atgcagtttg agagcagcag     2160

ctacgagggc tacttcctgg cctgcgagaa agagcgggac ctgttcaagc tgatcctgaa     2220

gaaagaggac gaactgggcg accgcagcat catgttcacc gtgcagaacg aggactgata     2280

a                                                                     2281


<210>  1657
<211>  2278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE68283z1XXFoxp3NFATIL18

<400>  1657
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactcct agaagacctg ggcctaccag aaagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgttca atgaactgca gaaagataag     1320

atggcggagg ccttcagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt tccagggtct cagtacagcc accaaggaca ccttcgacgc ccttcacatg     1440

caggccctgc cccctcgctg ataagtttaa actgccagaa catttctctg gcctaactgg     1500

ccggtaccgg cttcattttt tccatttact gcagaggctt cattttttcc atttactgca     1560

gaggcttcat tttttccatt tactgcagaa ctagttaggc gtgtacggtg ggaggcctat     1620

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt     1680

gacctccata gaagacaccg ggaccgatcc agcctcgaga gacccaatgc tagccaccat     1740

ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc     1800

gtacttcggc aagctggaaa gcaagctgag cgtgatccgg aacctgaacg accaggtgct     1860

gttcatcgat cagggcaaca gacccctgtt cgaggacatg accgacagcg actgcagaga     1920

caacgcccct cggaccatct tcatcatcag catgtacaag gacagccagc ctagaggcat     1980

ggccgtgacc atctctgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat     2040

catcagcttc aaagagatga acccgccgga caacatcaag gacaccaaga gcgacatcat     2100

attcttccag cggagcgtgc ccggccacga caacaagatg cagtttgaga gcagcagcta     2160

cgagggctac ttcctggcct gcgagaaaga gcgggacctg ttcaagctga tcctgaagaa     2220

agaggacgaa ctgggcgacc gcagcatcat gttcaccgtg cagaacgagg actgataa       2278


<210>  1658
<211>  2278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE68283z1XXFoxp3NFATIL18

<400>  1658
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaacaacaac ccctgccccc agacctccta ccccagcccc tacaattgcc      840

agccagcctc tgagcctgag gcccgaggct tgtagacctg ctgctggcgg agccgtgcac      900

accagaggac tggatttcgc ctgcgacatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca ggagtaagag gagcaggctc     1020

ctgcacagtg actacatgaa catgactcct agaagacctg ggcctaccag aaagcattac     1080

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgttca atgaactgca gaaagataag     1320

atggcggagg ccttcagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt tccagggtct cagtacagcc accaaggaca ccttcgacgc ccttcacatg     1440

caggccctgc cccctcgctg ataagtttaa actgccagaa catttctctg gcctaactgg     1500

ccggtaccgg cttcattttt tccatttact gcagaggctt cattttttcc atttactgca     1560

gaggcttcat tttttccatt tactgcagaa ctagttaggc gtgtacggtg ggaggcctat     1620

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt     1680

gacctccata gaagacaccg ggaccgatcc agcctcgaga gacccaatgc tagccaccat     1740

ggccttacca gtgaccgcct tgctcctgcc gctggccttg ctgctccacg ccgccaggcc     1800

gtacttcggc aagctggaaa gcaagctgag cgtgatccgg aacctgaacg accaggtgct     1860

gttcatcgat cagggcaaca gacccctgtt cgaggacatg accgacagcg actgcagaga     1920

caacgcccct cggaccatct tcatcatcag catgtacaag gacagccagc ctagaggcat     1980

ggccgtgacc atctctgtga agtgcgagaa gatcagcacc ctgagctgcg agaacaagat     2040

catcagcttc aaagagatga acccgccgga caacatcaag gacaccaaga gcgacatcat     2100

attcttccag cggagcgtgc ccggccacga caacaagatg cagtttgaga gcagcagcta     2160

cgagggctac ttcctggcct gcgagaaaga gcgggacctg ttcaagctga tcctgaagaa     2220

agaggacgaa ctgggcgacc gcagcatcat gttcaccgtg cagaacgagg actgataa       2278


<210>  1659
<211>  2293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10841BB3zFoxp3NFATIL18

<400>  1659
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctgataag tttaaactgc cagaacattt     1500

ctctggccta actggccggt accggcttca ttttttccat ttactgcaga ggcttcattt     1560

tttccattta ctgcagaggc ttcatttttt ccatttactg cagaactagt taggcgtgta     1620

cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc     1680

catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct cgagagaccc     1740

aatgctagcc accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct     1800

ccacgccgcc aggccgtact tcggcaagct ggaaagcaag ctgagcgtga tccggaacct     1860

gaacgaccag gtgctgttca tcgatcaggg caacagaccc ctgttcgagg acatgaccga     1920

cagcgactgc agagacaacg cccctcggac catcttcatc atcagcatgt acaaggacag     1980

ccagcctaga ggcatggccg tgaccatctc tgtgaagtgc gagaagatca gcaccctgag     2040

ctgcgagaac aagatcatca gcttcaaaga gatgaacccg ccggacaaca tcaaggacac     2100

caagagcgac atcatattct tccagcggag cgtgcccggc cacgacaaca agatgcagtt     2160

tgagagcagc agctacgagg gctacttcct ggcctgcgag aaagagcggg acctgttcaa     2220

gctgatcctg aagaaagagg acgaactggg cgaccgcagc atcatgttca ccgtgcagaa     2280

cgaggactga taa                                                        2293


<210>  1660
<211>  2296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10841BB3zFoxp3NFATIL18

<400>  1660
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aagtttaaac tgccagaaca     1500

tttctctggc ctaactggcc ggtaccggct tcattttttc catttactgc agaggcttca     1560

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaact agttaggcgt     1620

gtacggtggg aggcctatat aagcagagct cgtttagtga accgtcagat cgcctggaga     1680

cgccatccac gctgttttga cctccataga agacaccggg accgatccag cctcgagaga     1740

cccaatgcta gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct     1800

gctccacgcc gccaggccgt acttcggcaa gctggaaagc aagctgagcg tgatccggaa     1860

cctgaacgac caggtgctgt tcatcgatca gggcaacaga cccctgttcg aggacatgac     1920

cgacagcgac tgcagagaca acgcccctcg gaccatcttc atcatcagca tgtacaagga     1980

cagccagcct agaggcatgg ccgtgaccat ctctgtgaag tgcgagaaga tcagcaccct     2040

gagctgcgag aacaagatca tcagcttcaa agagatgaac ccgccggaca acatcaagga     2100

caccaagagc gacatcatat tcttccagcg gagcgtgccc ggccacgaca acaagatgca     2160

gtttgagagc agcagctacg agggctactt cctggcctgc gagaaagagc gggacctgtt     2220

caagctgatc ctgaagaaag aggacgaact gggcgaccgc agcatcatgt tcaccgtgca     2280

gaacgaggac tgataa                                                     2296


<210>  1661
<211>  2290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A108283zFoxp3NFATIL18

<400>  1661
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag     1020

aggagcaggc tcctgcacag tgactacatg aacatgactc ctagaagacc tgggcctacc     1080

agaaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataagttt aaactgccag aacatttctc     1500

tggcctaact ggccggtacc ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg     1620

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     1680

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat     1740

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     1800

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa     1860

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag     1920

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca     1980

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg     2040

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa     2100

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga     2160

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct     2220

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga     2280

ggactgataa                                                            2290


<210>  1662
<211>  2293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A108283zFoxp3NFATIL18

<400>  1662
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctgataag tttaaactgc cagaacattt     1500

ctctggccta actggccggt accggcttca ttttttccat ttactgcaga ggcttcattt     1560

tttccattta ctgcagaggc ttcatttttt ccatttactg cagaactagt taggcgtgta     1620

cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc     1680

catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct cgagagaccc     1740

aatgctagcc accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct     1800

ccacgccgcc aggccgtact tcggcaagct ggaaagcaag ctgagcgtga tccggaacct     1860

gaacgaccag gtgctgttca tcgatcaggg caacagaccc ctgttcgagg acatgaccga     1920

cagcgactgc agagacaacg cccctcggac catcttcatc atcagcatgt acaaggacag     1980

ccagcctaga ggcatggccg tgaccatctc tgtgaagtgc gagaagatca gcaccctgag     2040

ctgcgagaac aagatcatca gcttcaaaga gatgaacccg ccggacaaca tcaaggacac     2100

caagagcgac atcatattct tccagcggag cgtgcccggc cacgacaaca agatgcagtt     2160

tgagagcagc agctacgagg gctacttcct ggcctgcgag aaagagcggg acctgttcaa     2220

gctgatcctg aagaaagagg acgaactggg cgaccgcagc atcatgttca ccgtgcagaa     2280

cgaggactga taa                                                        2293


<210>  1663
<211>  2293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10841BB3z1XXFoxp3NFATIL18

<400>  1663
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataag tttaaactgc cagaacattt     1500

ctctggccta actggccggt accggcttca ttttttccat ttactgcaga ggcttcattt     1560

tttccattta ctgcagaggc ttcatttttt ccatttactg cagaactagt taggcgtgta     1620

cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc     1680

catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct cgagagaccc     1740

aatgctagcc accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct     1800

ccacgccgcc aggccgtact tcggcaagct ggaaagcaag ctgagcgtga tccggaacct     1860

gaacgaccag gtgctgttca tcgatcaggg caacagaccc ctgttcgagg acatgaccga     1920

cagcgactgc agagacaacg cccctcggac catcttcatc atcagcatgt acaaggacag     1980

ccagcctaga ggcatggccg tgaccatctc tgtgaagtgc gagaagatca gcaccctgag     2040

ctgcgagaac aagatcatca gcttcaaaga gatgaacccg ccggacaaca tcaaggacac     2100

caagagcgac atcatattct tccagcggag cgtgcccggc cacgacaaca agatgcagtt     2160

tgagagcagc agctacgagg gctacttcct ggcctgcgag aaagagcggg acctgttcaa     2220

gctgatcctg aagaaagagg acgaactggg cgaccgcagc atcatgttca ccgtgcagaa     2280

cgaggactga taa                                                        2293


<210>  1664
<211>  2296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10841BB3z1XXFoxp3NFATIL18

<400>  1664
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat     1320

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc     1440

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aagtttaaac tgccagaaca     1500

tttctctggc ctaactggcc ggtaccggct tcattttttc catttactgc agaggcttca     1560

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaact agttaggcgt     1620

gtacggtggg aggcctatat aagcagagct cgtttagtga accgtcagat cgcctggaga     1680

cgccatccac gctgttttga cctccataga agacaccggg accgatccag cctcgagaga     1740

cccaatgcta gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct     1800

gctccacgcc gccaggccgt acttcggcaa gctggaaagc aagctgagcg tgatccggaa     1860

cctgaacgac caggtgctgt tcatcgatca gggcaacaga cccctgttcg aggacatgac     1920

cgacagcgac tgcagagaca acgcccctcg gaccatcttc atcatcagca tgtacaagga     1980

cagccagcct agaggcatgg ccgtgaccat ctctgtgaag tgcgagaaga tcagcaccct     2040

gagctgcgag aacaagatca tcagcttcaa agagatgaac ccgccggaca acatcaagga     2100

caccaagagc gacatcatat tcttccagcg gagcgtgccc ggccacgaca acaagatgca     2160

gtttgagagc agcagctacg agggctactt cctggcctgc gagaaagagc gggacctgtt     2220

caagctgatc ctgaagaaag aggacgaact gggcgaccgc agcatcatgt tcaccgtgca     2280

gaacgaggac tgataa                                                     2296


<210>  1665
<211>  2290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A108283z1XXFoxp3NFATIL18

<400>  1665
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagacaaca acccctgccc ccagacctcc taccccagcc      840

cctacaattg ccagccagcc tctgagcctg aggcccgagg cttgtagacc tgctgctggc      900

ggagccgtgc acaccagagg actggatttc gcctgcgaca tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caggagtaag     1020

aggagcaggc tcctgcacag tgactacatg aacatgactc ctagaagacc tgggcctacc     1080

agaaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctccagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgtt caatgaactg     1320

cagaaagata agatggcgga ggccttcagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct tttccagggt ctcagtacag ccaccaagga caccttcgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataagttt aaactgccag aacatttctc     1500

tggcctaact ggccggtacc ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg     1620

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     1680

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat     1740

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     1800

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa     1860

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag     1920

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca     1980

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg     2040

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa     2100

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga     2160

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct     2220

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga     2280

ggactgataa                                                            2290


<210>  1666
<211>  2293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A108283z1XXFoxp3NFATIL18

<400>  1666
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataag tttaaactgc cagaacattt     1500

ctctggccta actggccggt accggcttca ttttttccat ttactgcaga ggcttcattt     1560

tttccattta ctgcagaggc ttcatttttt ccatttactg cagaactagt taggcgtgta     1620

cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc     1680

catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct cgagagaccc     1740

aatgctagcc accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct     1800

ccacgccgcc aggccgtact tcggcaagct ggaaagcaag ctgagcgtga tccggaacct     1860

gaacgaccag gtgctgttca tcgatcaggg caacagaccc ctgttcgagg acatgaccga     1920

cagcgactgc agagacaacg cccctcggac catcttcatc atcagcatgt acaaggacag     1980

ccagcctaga ggcatggccg tgaccatctc tgtgaagtgc gagaagatca gcaccctgag     2040

ctgcgagaac aagatcatca gcttcaaaga gatgaacccg ccggacaaca tcaaggacac     2100

caagagcgac atcatattct tccagcggag cgtgcccggc cacgacaaca agatgcagtt     2160

tgagagcagc agctacgagg gctacttcct ggcctgcgag aaagagcggg acctgttcaa     2220

gctgatcctg aagaaagagg acgaactggg cgaccgcagc atcatgttca ccgtgcagaa     2280

cgaggactga taa                                                        2293


<210>  1667
<211>  2290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6841BB3zFoxp3NFATIL18

<400>  1667
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataagttt aaactgccag aacatttctc     1500

tggcctaact ggccggtacc ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg     1620

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     1680

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat     1740

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     1800

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa     1860

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag     1920

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca     1980

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg     2040

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa     2100

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga     2160

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct     2220

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga     2280

ggactgataa                                                            2290


<210>  1668
<211>  2290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6841BB3zFoxp3NFATIL18

<400>  1668
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataagttt aaactgccag aacatttctc     1500

tggcctaact ggccggtacc ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg     1620

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     1680

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat     1740

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     1800

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa     1860

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag     1920

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca     1980

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg     2040

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa     2100

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga     2160

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct     2220

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga     2280

ggactgataa                                                            2290


<210>  1669
<211>  2287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E68283zFoxp3NFATIL18

<400>  1669
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taagtttaaa ctgccagaac atttctctgg     1500

cctaactggc cggtaccggc ttcatttttt ccatttactg cagaggcttc attttttcca     1560

tttactgcag aggcttcatt ttttccattt actgcagaac tagttaggcg tgtacggtgg     1620

gaggcctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     1680

cgctgttttg acctccatag aagacaccgg gaccgatcca gcctcgagag acccaatgct     1740

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     1800

cgccaggccg tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga     1860

ccaggtgctg ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga     1920

ctgcagagac aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc     1980

tagaggcatg gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga     2040

gaacaagatc atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag     2100

cgacatcata ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag     2160

cagcagctac gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat     2220

cctgaagaaa gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga     2280

ctgataa                                                               2287


<210>  1670
<211>  2287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E68283zFoxp3NFATIL18

<400>  1670
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taagtttaaa ctgccagaac atttctctgg     1500

cctaactggc cggtaccggc ttcatttttt ccatttactg cagaggcttc attttttcca     1560

tttactgcag aggcttcatt ttttccattt actgcagaac tagttaggcg tgtacggtgg     1620

gaggcctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     1680

cgctgttttg acctccatag aagacaccgg gaccgatcca gcctcgagag acccaatgct     1740

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     1800

cgccaggccg tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga     1860

ccaggtgctg ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga     1920

ctgcagagac aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc     1980

tagaggcatg gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga     2040

gaacaagatc atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag     2100

cgacatcata ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag     2160

cagcagctac gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat     2220

cctgaagaaa gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga     2280

ctgataa                                                               2287


<210>  1671
<211>  2290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6841BB3z1XXFoxp3NFATIL18

<400>  1671
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgtt caatgaactg     1320

cagaaagata agatggcgga ggccttcagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct tttccagggt ctcagtacag ccaccaagga caccttcgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataagttt aaactgccag aacatttctc     1500

tggcctaact ggccggtacc ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg     1620

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     1680

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat     1740

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     1800

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa     1860

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag     1920

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca     1980

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg     2040

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa     2100

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga     2160

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct     2220

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga     2280

ggactgataa                                                            2290


<210>  1672
<211>  2290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6841BB3z1XXFoxp3NFATIL18

<400>  1672
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgtt caatgaactg     1320

cagaaagata agatggcgga ggccttcagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct tttccagggt ctcagtacag ccaccaagga caccttcgac     1440

gcccttcaca tgcaggccct gccccctcgc tgataagttt aaactgccag aacatttctc     1500

tggcctaact ggccggtacc ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaggcttc attttttcca tttactgcag aactagttag gcgtgtacgg     1620

tgggaggcct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     1680

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctcga gagacccaat     1740

gctagccacc atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca     1800

cgccgccagg ccgtacttcg gcaagctgga aagcaagctg agcgtgatcc ggaacctgaa     1860

cgaccaggtg ctgttcatcg atcagggcaa cagacccctg ttcgaggaca tgaccgacag     1920

cgactgcaga gacaacgccc ctcggaccat cttcatcatc agcatgtaca aggacagcca     1980

gcctagaggc atggccgtga ccatctctgt gaagtgcgag aagatcagca ccctgagctg     2040

cgagaacaag atcatcagct tcaaagagat gaacccgccg gacaacatca aggacaccaa     2100

gagcgacatc atattcttcc agcggagcgt gcccggccac gacaacaaga tgcagtttga     2160

gagcagcagc tacgagggct acttcctggc ctgcgagaaa gagcgggacc tgttcaagct     2220

gatcctgaag aaagaggacg aactgggcga ccgcagcatc atgttcaccg tgcagaacga     2280

ggactgataa                                                            2290


<210>  1673
<211>  2287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E68283z1XXFoxp3NFATIL18

<400>  1673
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgttcaa tgaactgcag     1320

aaagataaga tggcggaggc cttcagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac cttcgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taagtttaaa ctgccagaac atttctctgg     1500

cctaactggc cggtaccggc ttcatttttt ccatttactg cagaggcttc attttttcca     1560

tttactgcag aggcttcatt ttttccattt actgcagaac tagttaggcg tgtacggtgg     1620

gaggcctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     1680

cgctgttttg acctccatag aagacaccgg gaccgatcca gcctcgagag acccaatgct     1740

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     1800

cgccaggccg tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga     1860

ccaggtgctg ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga     1920

ctgcagagac aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc     1980

tagaggcatg gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga     2040

gaacaagatc atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag     2100

cgacatcata ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag     2160

cagcagctac gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat     2220

cctgaagaaa gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga     2280

ctgataa                                                               2287


<210>  1674
<211>  2287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E68283z1XXFoxp3NFATIL18

<400>  1674
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gacaacaacc cctgccccca gacctcctac cccagcccct      840

acaattgcca gccagcctct gagcctgagg cccgaggctt gtagacctgc tgctggcgga      900

gccgtgcaca ccagaggact ggatttcgcc tgcgacatct acatctgggc gcccttggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcag gagtaagagg     1020

agcaggctcc tgcacagtga ctacatgaac atgactccta gaagacctgg gcctaccaga     1080

aagcattacc agccctatgc cccaccacgc gacttcgcag cctatcgctc cagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgttcaa tgaactgcag     1320

aaagataaga tggcggaggc cttcagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggcctttt ccagggtctc agtacagcca ccaaggacac cttcgacgcc     1440

cttcacatgc aggccctgcc ccctcgctga taagtttaaa ctgccagaac atttctctgg     1500

cctaactggc cggtaccggc ttcatttttt ccatttactg cagaggcttc attttttcca     1560

tttactgcag aggcttcatt ttttccattt actgcagaac tagttaggcg tgtacggtgg     1620

gaggcctata taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca     1680

cgctgttttg acctccatag aagacaccgg gaccgatcca gcctcgagag acccaatgct     1740

agccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc     1800

cgccaggccg tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga     1860

ccaggtgctg ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga     1920

ctgcagagac aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc     1980

tagaggcatg gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga     2040

gaacaagatc atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag     2100

cgacatcata ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag     2160

cagcagctac gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat     2220

cctgaagaaa gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga     2280

ctgataa                                                               2287


<210>  1675
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV h20A10-O CAR 41BB

<400>  1675
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga catcgtgatg      480

acacagagcc ctgatagcct ggccgtgtct ctgggagaga gagccaccat caactgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agcctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tttctggcag cggctctggc accgacttca ccctgacaat tagctccctg      720

caggccgagg atgtggccgt gtactactgt caccagtacc tgagcagcct gacctttggc      780

ggcggaacaa aggtggaaat caagcgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  1676
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1676
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1677
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10O scFV

<400>  1677
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgaca      420

cagagccctg atagcctggc cgtgtctctg ggagagagag ccaccatcaa ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccagc ctcctaagct gctgatctac tgggccagca ccagagaaag cggcgtgccc      600

gatagatttt ctggcagcgg ctctggcacc gacttcaccc tgacaattag ctccctgcag      660

gccgaggatg tggccgtgta ctactgtcac cagtacctga gcagcctgac ctttggcggc      720

ggaacaaagg tggaaatcaa gcga                                             744


<210>  1678
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1678
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1679
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1679
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1680
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10N scFV

<400>  1680
caggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtggcgtct attggcagag ccggcagcac ctactacagc      180

gactctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtttctagc      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgaaat tgtgctgaca      420

cagagccccg ccacactgtc actttctcca ggcgaaagag ccacactgag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccaag ctcctcggct gctgatctat tgggccagca caagagagag cggcatccct      600

gccagatttt ctggcagcgg ctctggcacc gatttcaccc tgaccataag cagcctggaa      660

cctgaggact tcgccgtgta ttactgccac cagtacctga gcagcctgac ctttggcgga      720

ggcaccaagg tggaaatcaa gcgg                                             744


<210>  1681
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1681
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1682
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  1682
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1683
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB

<400>  1683
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  1684
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3

<400>  1684
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1685
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV h20A10-C2 CAR 41BB

<400>  1685
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  1686
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1686
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1687
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10C2 scFV

<400>  1687
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat tgtgctgacc      420

cagtctccag cctccttggc cgtgtctcca ggacagaggg ccaccatcac ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaaa      540

ccaggacaac ctcctaaact cctgatttac tgggccagca ccagagaaag cggggtccca      600

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      660

gctaatgata ctgcaaatta ttactgtcac cagtacctga gcagcctgac cttcggcgga      720

gggaccaagg tggagatcaa acga                                             744


<210>  1688
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1688
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1689
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane region

<400>  1689
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1690
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB

<400>  1690
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  1691
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3

<400>  1691
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1692
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV h20A10-O CAR CD28 1XX

<400>  1692
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga catcgtgatg      480

acacagagcc ctgatagcct ggccgtgtct ctgggagaga gagccaccat caactgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agcctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tttctggcag cggctctggc accgacttca ccctgacaat tagctccctg      720

caggccgagg atgtggccgt gtactactgt caccagtacc tgagcagcct gacctttggc      780

ggcggaacaa aggtggaaat caagcgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1693
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1693
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1694
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10O scFV

<400>  1694
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgaca      420

cagagccctg atagcctggc cgtgtctctg ggagagagag ccaccatcaa ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccagc ctcctaagct gctgatctac tgggccagca ccagagaaag cggcgtgccc      600

gatagatttt ctggcagcgg ctctggcacc gacttcaccc tgacaattag ctccctgcag      660

gccgaggatg tggccgtgta ctactgtcac cagtacctga gcagcctgac ctttggcggc      720

ggaacaaagg tggaaatcaa gcga                                             744


<210>  1695
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1695
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1696
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane region

<400>  1696
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1697
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28

<400>  1697
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc tagaagacct       60

gggcctacca gaaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1698
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 1XX

<400>  1698
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1699
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV h20A10-N CAR CD28 1XX

<400>  1699
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatcagacag      180

gcccctggca aaggcctgga atgggtggcg tctattggca gagccggcag cacctactac      240

agcgactctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtttct      420

agcggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga aattgtgctg      480

acacagagcc ccgccacact gtcactttct ccaggcgaaa gagccacact gagctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc aagctcctcg gctgctgatc tattgggcca gcacaagaga gagcggcatc      660

cctgccagat tttctggcag cggctctggc accgatttca ccctgaccat aagcagcctg      720

gaacctgagg acttcgccgt gtattactgc caccagtacc tgagcagcct gacctttggc      780

ggaggcacca aggtggaaat caagcggaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1700
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1700
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1701
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10N scFV

<400>  1701
caggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtggcgtct attggcagag ccggcagcac ctactacagc      180

gactctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtttctagc      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgaaat tgtgctgaca      420

cagagccccg ccacactgtc actttctcca ggcgaaagag ccacactgag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccaag ctcctcggct gctgatctat tgggccagca caagagagag cggcatccct      600

gccagatttt ctggcagcgg ctctggcacc gatttcaccc tgaccataag cagcctggaa      660

cctgaggact tcgccgtgta ttactgccac cagtacctga gcagcctgac ctttggcgga      720

ggcaccaagg tggaaatcaa gcgg                                             744


<210>  1702
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1702
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1703
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  1703
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1704
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28

<400>  1704
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc tagaagacct       60

gggcctacca gaaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1705
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 1XX

<400>  1705
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1706
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV h20A10-C2 CAR CD28 1XX

<400>  1706
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaca acaacccctg cccccagacc tcctacccca      840

gcccctacaa ttgccagcca gcctctgagc ctgaggcccg aggcttgtag acctgctgct      900

ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaggagt     1020

aagaggagca ggctcctgca cagtgactac atgaacatga ctcctagaag acctgggcct     1080

accagaaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gttcaatgaa     1320

ctgcagaaag ataagatggc ggaggccttc agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg ccttttccag ggtctcagta cagccaccaa ggacaccttc     1440

gacgcccttc acatgcaggc cctgccccct cgctgataa                            1479


<210>  1707
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1707
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1708
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10C2 scFV

<400>  1708
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat tgtgctgacc      420

cagtctccag cctccttggc cgtgtctcca ggacagaggg ccaccatcac ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaaa      540

ccaggacaac ctcctaaact cctgatttac tgggccagca ccagagaaag cggggtccca      600

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      660

gctaatgata ctgcaaatta ttactgtcac cagtacctga gcagcctgac cttcggcgga      720

gggaccaagg tggagatcaa acga                                             744


<210>  1709
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1709
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1710
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane region

<400>  1710
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1711
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28

<400>  1711
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc tagaagacct       60

gggcctacca gaaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1712
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 1XX

<400>  1712
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1713
<211>  2380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV hC2 CAR 41BB 6xNFATFoxP3 IL18

<400>  1713
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct gataagttta aactgccaga     1500

acatttctct ggcctaactg gccggtaccg gcttcatttt ttccatttac tgcagaggct     1560

tcattttttc catttactgc agaggcttca ttttttccat ttactgcaga ggcttcattt     1620

tttccattta ctgcagaggc ttcatttttt ccatttactg cagaggcttc attttttcca     1680

tttactgcag aactagttag gcgtgtacgg tgggaggcct atataagcag agctcgttta     1740

gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac     1800

cgggaccgat ccagcctcga gagacccaat gctagccacc atggccttac cagtgaccgc     1860

cttgctcctg ccgctggcct tgctgctcca cgccgccagg ccgtacttcg gcaagctgga     1920

aagcaagctg agcgtgatcc ggaacctgaa cgaccaggtg ctgttcatcg atcagggcaa     1980

cagacccctg ttcgaggaca tgaccgacag cgactgcaga gacaacgccc ctcggaccat     2040

cttcatcatc agcatgtaca aggacagcca gcctagaggc atggccgtga ccatctctgt     2100

gaagtgcgag aagatcagca ccctgagctg cgagaacaag atcatcagct tcaaagagat     2160

gaacccgccg gacaacatca aggacaccaa gagcgacatc atattcttcc agcggagcgt     2220

gcccggccac gacaacaaga tgcagtttga gagcagcagc tacgagggct acttcctggc     2280

ctgcgagaaa gagcgggacc tgttcaagct gatcctgaag aaagaggacg aactgggcga     2340

ccgcagcatc atgttcaccg tgcagaacga ggactgataa                           2380


<210>  1714
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1714
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1715
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 scFV

<400>  1715
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  1716
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1716
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1717
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane region

<400>  1717
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1718
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB

<400>  1718
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  1719
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3

<400>  1719
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  1720
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  1720
tgataagttt aaactgccag aacatttctc tggcctaact ggccggtacc                  50


<210>  1721
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6xNFAT FoxP3

<400>  1721
ggcttcattt tttccattta ctgcagaggc ttcatttttt ccatttactg cagaggcttc       60

attttttcca tttactgcag aggcttcatt ttttccattt actgcagagg cttcattttt      120

tccatttact gcagaggctt cattttttcc atttactgca gaactagt                   168


<210>  1722
<211>  118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCMV

<400>  1722
taggcgtgta cggtgggagg cctatataag cagagctcgt ttagtgaacc gtcagatcgc       60

ctggagacgc catccacgct gttttgacct ccatagaaga caccgggacc gatccagc        118


<210>  1723
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  1723
ctcgagagac ccaatgctag ccacc                                             25


<210>  1724
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1724
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1725
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL18

<400>  1725
tacttcggca agctggaaag caagctgagc gtgatccgga acctgaacga ccaggtgctg       60

ttcatcgatc agggcaacag acccctgttc gaggacatga ccgacagcga ctgcagagac      120

aacgcccctc ggaccatctt catcatcagc atgtacaagg acagccagcc tagaggcatg      180

gccgtgacca tctctgtgaa gtgcgagaag atcagcaccc tgagctgcga gaacaagatc      240

atcagcttca aagagatgaa cccgccggac aacatcaagg acaccaagag cgacatcata      300

ttcttccagc ggagcgtgcc cggccacgac aacaagatgc agtttgagag cagcagctac      360

gagggctact tcctggcctg cgagaaagag cgggacctgt tcaagctgat cctgaagaaa      420

gaggacgaac tgggcgaccg cagcatcatg ttcaccgtgc agaacgagga ctgataa         477


<210>  1726
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDH MSCV hC2 CAR CD28 1XX

<400>  1726
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact acaacaaccc ctgcccccag acctcctacc      840

ccagccccta caattgccag ccagcctctg agcctgaggc ccgaggcttg tagacctgct      900

gctggcggag ccgtgcacac cagaggactg gatttcgcct gcgacatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcagg     1020

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactcctag aagacctggg     1080

cctaccagaa agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat     1320

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc     1440

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                        1482


<210>  1727
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1727
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1728
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2 scFV

<400>  1728
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  1729
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge region

<400>  1729
acaacaaccc ctgcccccag acctcctacc ccagccccta caattgccag ccagcctctg       60

agcctgaggc ccgaggcttg tagacctgct gctggcggag ccgtgcacac cagaggactg      120

gatttcgcct gcgac                                                       135


<210>  1730
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane region

<400>  1730
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1731
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28

<400>  1731
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc tagaagacct       60

gggcctacca gaaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1732
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 1XX

<400>  1732
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1733
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 2 (FR2) sequence

<400>  1733
tggtatcagc agaaaccagg acagccaccc aaactcctca tctat                       45


<210>  1734
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 2 (FR2) sequence

<400>  1734

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  1735
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1735
cttgcatcca ccctagattc t                                                 21


<210>  1736
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable complementarity determining 
       regions 2 (CDR2) sequence

<400>  1736

Leu Ala Ser Thr Leu Asp Ser 
1               5           


<210>  1737
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 3 (FR3) sequence

<400>  1737
ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat       60

cctgtggagg ctgatgatgc tgcaacctat tactgt                                 96


<210>  1738
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 3 (FR3) sequence

<400>  1738

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  1739
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1739
cagcaaaata atgaggatcc tccgacg                                           27


<210>  1740
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable complementarity determining 
       regions 3 (CDR3) sequence

<400>  1740

Gln Gln Asn Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  1741
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 4 (FR4) sequence

<400>  1741
ttcggtggag gcaccaagct ggaaatcaag g                                      31


<210>  1742
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse B12 light chain variable framework 4 (FR4) sequence

<400>  1742

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  1743
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope to which NME1 and NME7AB bind part of the 10 membrane 
       proximal PRT

<400>  1743

Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
1               5                   10  


<210>  1744
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope to which NME1 and NME7AB bind part of the 10 membrane 
       proximal PRT

<400>  1744

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val 
1               5                   10      


<210>  1745
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope to which NME1 and NME7AB bind part of the 10 membrane 
       proximal PRT

<400>  1745

Ala Ser Arg Tyr Asn Leu Thr 
1               5           


<210>  1746
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PSMGFR

<400>  1746

Gly Thr Ile Asn Val His Asp Val Glu Thr 
1               5                   10  


<210>  1747
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PSMGFR

<400>  1747

Phe Pro Phe Ser 
1               


<210>  1748
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PSMGFR

<400>  1748

Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu 
1               5                   10                  15      


Ala Phe Arg Glu 
            20  


<210>  1749
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PSMGFR

<400>  1749

Gln Phe Asn Gln Tyr Lys Thr Glu Ala 
1               5                   


<210>  1750
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PSMGFR

<400>  1750

Val Gln Leu Thr Leu Ala Phe Arg Glu 
1               5                   


<210>  1751
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment of PSMGFR

<400>  1751

Ser Val Ser Asp Val 
1               5   


<210>  1752
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL18 sequence

<400>  1752
atagaagaca ccgggaccga tccagcctcg agagacccaa tgctagccac catggcctta       60

ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag gccgtacttc      120

ggcaagctgg aaagcaagct gagcgtgatc cggaacctga acgaccaggt gctgttcatc      180

gatcagggca acagacccct gttcgaggac atgaccgaca gcgactgcag agacaacgcc      240

cctcggacca tcttcatcat cagcatgtac aaggacagcc agcctagagg catggccgtg      300

accatctctg tgaagtgcga gaagatcagc accctgagct gcgagaacaa gatcatcagc      360

ttcaaagaga tgaacccgcc ggacaacatc aaggacacca agagcgacat catattcttc      420

cagcggagcg tgcccggcca cgacaacaag atgcagtttg agagcagcag ctacgagggc      480

tacttcctgg cctgcgagaa agagcgggac ctgttcaagc tgatcctgaa gaaagaggac      540

gaactgggcg accgcagcat catgttcacc gtgcagaacg aggactgata aaagcttggc      600

aatccggtac tgttggtaaa gccacca                                          627


<210>  1753
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL18 sequence

<400>  1753

Ile Glu Asp Thr Gly Thr Asp Pro Ala Ser Arg Asp Pro Met Leu Ala 
1               5                   10                  15      


Thr Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
            20                  25                  30          


Leu His Ala Ala Arg Pro Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser 
        35                  40                  45              


Val Ile Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn 
    50                  55                  60                  


Arg Pro Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala 
65                  70                  75                  80  


Pro Arg Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg 
                85                  90                  95      


Gly Met Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu 
            100                 105                 110         


Ser Cys Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp 
        115                 120                 125             


Asn Ile Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val 
    130                 135                 140                 


Pro Gly His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly 
145                 150                 155                 160 


Tyr Phe Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu 
                165                 170                 175     


Lys Lys Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln 
            180                 185                 190         


Asn Glu Asp Lys Leu Gly Asn Pro Val Leu Leu Val Lys Pro Pro 
        195                 200                 205         


<210>  1754
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1754
agggagaccc aagctggcta gttaagcttg gatggcctta ccagtgaccg ccttgc           56


<210>  1755
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1755
taggccagag aaatgttctg gcattatcag cgagggggca gggcctgc                    48


<210>  1756
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1756
tgccagaaca tttctctgg                                                    19


<210>  1757
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1757
acagtcgagg ctgatcagcg ggtttaaact tatcagtcct cgttctgcac gg               52


<210>  1758
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1758
atgcaggccc tgccccctcg ctgataagtt taaactgcca gaacatttct ctggcctaac       60


<210>  1759
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1759
accggagcga tcgcagatcc ttcgcggccg cttatcagtc ctcgttctgc acggtgaac        59


<210>  1760
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1760
attgcactag ttgaaagacc ccacctgtag g                                      31


<210>  1761
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1761
aatgctctag aatacgggta tccagg                                            26


<210>  1762
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1762
atagcgaatt cgtaccgagg gccaccatgg                                        30


<210>  1763
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1763
taggcctccc accgtacacg cctaggtacc acgccttctg tatg                        44


<210>  1764
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1764
taggcctccc accgtacacg cctaggtacc tctgcagtaa atgg                        44


<210>  1765
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1765
taaggccatg gtggctagc                                                    19


<210>  1766
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1766
aataagttta aactgccaga acatttctct gg                                     32


<210>  1767
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  1767
atatagcggc cgcttatcag tcctcgttct gcacgg                                 36


<210>  1768
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x FoxP3NFAT mCMV

<400>  1768
agaacatttc tctggcctaa ctggccggta ccggcttcat tttttccatt tactgcagag       60

gcttcatttt ttccatttac tgcagaggct tcattttttc catttactgc agaggcttca      120

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaggc ttcatttttt      180

ccatttactg cagaactagt taggcgtgta cggtgggagg cctatataag cagagctcgt      240

ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga      300

caccgggacc gatccagcct cgagagaccc aatgctagcc accatgg                    347


<210>  1769
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x FoxP3NFAT mCMV

<400>  1769

Arg Thr Phe Leu Trp Pro Asn Trp Pro Val Pro Ala Ser Phe Phe Pro 
1               5                   10                  15      


Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala Glu Ala Ser Phe 
            20                  25                  30          


Phe Pro Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala Glu Ala 
        35                  40                  45              


Ser Phe Phe Pro Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala 
    50                  55                  60                  


Glu Leu Val Arg Arg Val Arg Trp Glu Ala Tyr Ile Ser Arg Ala Arg 
65                  70                  75                  80  


Leu Val Asn Arg Gln Ile Ala Trp Arg Arg His Pro Arg Cys Phe Asp 
                85                  90                  95      


Leu His Arg Arg His Arg Asp Arg Ser Ser Leu Glu Arg Pro Asn Ala 
            100                 105                 110         


Ser His His Gly 
        115     


<210>  1770
<211>  343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x FoxP3NFAT mIL2P

<400>  1770
agaacatttc tctggcctaa ctggccggta ccggcttcat tttttccatt tactgcagag       60

gcttcatttt ttccatttac tgcagaggct tcattttttc catttactgc agaggcttca      120

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaggc ttcatttttt      180

ccatttactg cagaactagt cattttgaca cccccataat atttttccag aattaacagt      240

ataaattgca tctcttgttc aagagttccc tatcactctc tttaatcact actcacagta      300

acctcaactc ctgcctcgag agacccaatg ctagccacca tgg                        343


<210>  1771
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x FoxP3NFAT mIL2P


<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<400>  1771

Arg Thr Phe Leu Trp Pro Asn Trp Pro Val Pro Ala Ser Phe Phe Pro 
1               5                   10                  15      


Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala Glu Ala Ser Phe 
            20                  25                  30          


Phe Pro Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala Glu Ala 
        35                  40                  45              


Ser Phe Phe Pro Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala 
    50                  55                  60                  


Glu Leu Val Ile Leu Thr Pro Pro Tyr Phe Ser Arg Ile Asn Ser Ile 
65                  70                  75                  80  


Asn Cys Ile Ser Cys Ser Arg Val Pro Tyr His Ser Leu Ser Leu Leu 
                85                  90                  95      


Thr Val Thr Ser Thr Pro Ala Ser Arg Asp Pro Met Leu Ala Thr Met 
            100                 105                 110         


Xaa 
    


<210>  1772
<211>  260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x FoxP3NFAT miniP

<400>  1772
agaacatttc tctggcctaa ctggccggta ccggcttcat tttttccatt tactgcagag       60

gcttcatttt ttccatttac tgcagaggct tcattttttc catttactgc agaggcttca      120

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaggc ttcatttttt      180

ccatttactg cagaactagt agagggtata taatggaagc tcgacttcca gctcgagaga      240

cccaatgcta gccaccatgg                                                  260


<210>  1773
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x FoxP3NFAT miniP

<400>  1773

Arg Thr Phe Leu Trp Pro Asn Trp Pro Val Pro Ala Ser Phe Phe Pro 
1               5                   10                  15      


Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala Glu Ala Ser Phe 
            20                  25                  30          


Phe Pro Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala Glu Ala 
        35                  40                  45              


Ser Phe Phe Pro Phe Thr Ala Glu Ala Ser Phe Phe Pro Phe Thr Ala 
    50                  55                  60                  


Glu Leu Val Glu Gly Ile Trp Lys Leu Asp Phe Gln Leu Glu Arg Pro 
65                  70                  75                  80  


Asn Ala Ser His His Gly 
                85      


<210>  1774
<211>  365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x IL2NFAT mCMV

<400>  1774
agaacatttc tctggcctaa ctggccggta ccggaggaaa aactgtttca tacagaaggc       60

gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca tacagaaggc      120

gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca tacagaaggc      180

gtggaggaaa aactgtttca tacagaaggc gtactagtta ggcgtgtacg gtgggaggcc      240

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt      300

tttgacctcc atagaagaca ccgggaccga tccagcctcg agagacccaa tgctagccac      360

catgg                                                                  365


<210>  1775
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x IL2NFAT mCMV

<400>  1775

Arg Thr Phe Leu Trp Pro Asn Trp Pro Val Pro Glu Glu Lys Leu Phe 
1               5                   10                  15      


His Thr Glu Gly Val Glu Glu Lys Leu Phe His Thr Glu Gly Val Glu 
            20                  25                  30          


Glu Lys Leu Phe His Thr Glu Gly Val Glu Glu Lys Leu Phe His Thr 
        35                  40                  45              


Glu Gly Val Glu Glu Lys Leu Phe His Thr Glu Gly Val Glu Glu Lys 
    50                  55                  60                  


Leu Phe His Thr Glu Gly Val Leu Val Arg Arg Val Arg Trp Glu Ala 
65                  70                  75                  80  


Tyr Ile Ser Arg Ala Arg Leu Val Asn Arg Gln Ile Ala Trp Arg Arg 
                85                  90                  95      


His Pro Arg Cys Phe Asp Leu His Arg Arg His Arg Asp Arg Ser Ser 
            100                 105                 110         


Leu Glu Arg Pro Asn Ala Ser His His Gly 
        115                 120         


<210>  1776
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x IL2NFAT mIL2P

<400>  1776
agaacatttc tctggcctaa ctggccggta ccggaggaaa aactgtttca tacagaaggc       60

gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca tacagaaggc      120

gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca tacagaaggc      180

gtggaggaaa aactgtttca tacagaaggc gtactagtca ttttgacacc cccataatat      240

ttttccagaa ttaacagtat aaattgcatc tcttgttcaa gagttcccta tcactctctt      300

taatcactac tcacagtaac ctcaactcct gcctcgagag acccaatgct agccaccatg      360

g                                                                      361


<210>  1777
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x IL2NFAT mIL2P


<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa can be any naturally occurring amino acid

<400>  1777

Arg Thr Phe Leu Trp Pro Asn Trp Pro Val Pro Glu Glu Lys Leu Phe 
1               5                   10                  15      


His Thr Glu Gly Val Glu Glu Lys Leu Phe His Thr Glu Gly Val Glu 
            20                  25                  30          


Glu Lys Leu Phe His Thr Glu Gly Val Glu Glu Lys Leu Phe His Thr 
        35                  40                  45              


Glu Gly Val Glu Glu Lys Leu Phe His Thr Glu Gly Val Glu Glu Lys 
    50                  55                  60                  


Leu Phe His Thr Glu Gly Val Leu Val Ile Leu Thr Pro Pro Tyr Phe 
65                  70                  75                  80  


Ser Arg Ile Asn Ser Ile Asn Cys Ile Ser Cys Ser Arg Val Pro Tyr 
                85                  90                  95      


His Ser Leu Ser Leu Leu Thr Val Thr Ser Thr Pro Ala Ser Arg Asp 
            100                 105                 110         


Pro Met Leu Ala Thr Met Xaa 
        115                 


<210>  1778
<211>  278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6x IL2NFAT miniP

<400>  1778
agaacatttc tctggcctaa ctggccggta ccggaggaaa aactgtttca tacagaaggc       60

gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca tacagaaggc      120

gtggaggaaa aactgtttca tacagaaggc gtggaggaaa aactgtttca tacagaaggc      180

gtggaggaaa aactgtttca tacagaaggc gtactagtag agggtatata atggaagctc      240

gacttccagc tcgagagacc caatgctagc caccatgg                              278


<210>  1779
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6x IL2NFAT miniP

<400>  1779

Arg Thr Phe Leu Trp Pro Asn Trp Pro Val Pro Glu Glu Lys Leu Phe 
1               5                   10                  15      


His Thr Glu Gly Val Glu Glu Lys Leu Phe His Thr Glu Gly Val Glu 
            20                  25                  30          


Glu Lys Leu Phe His Thr Glu Gly Val Glu Glu Lys Leu Phe His Thr 
        35                  40                  45              


Glu Gly Val Glu Glu Lys Leu Phe His Thr Glu Gly Val Glu Glu Lys 
    50                  55                  60                  


Leu Phe His Thr Glu Gly Val Leu Val Glu Gly Ile Trp Lys Leu Asp 
65                  70                  75                  80  


Phe Gln Leu Glu Arg Pro Asn Ala Ser His His Gly 
                85                  90          


<210>  1780
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME1

<400>  1780
atggccaact gtgagcgtac cttcattgcg atcaaaccag atggggtcca gcggggtctt       60

gtgggagaga ttatcaagcg ttttgagcag aaaggattcc gccttgttgg tctgaaattc      120

atgcaagctt ccgaagatct tctcaaggaa cactacgttg acctgaagga ccgtccattc      180

tttgccggcc tggtgaaata catgcactca gggccggtag ttgccatggt ctgggagggg      240

ctgaatgtgg tgaagacggg ccgagtcatg ctcggggaga ccaaccctgc agactccaag      300

cctgggacca tccgtggaga cttctgcata caagttggca ggaacattat acatggcagt      360

gattctgtgg agagtgcaga gaaggagatc ggcttgtggt ttcaccctga ggaactggta      420

gattacacga gctgtgctca gaactggatc tatgaatga                             459


<210>  1781
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME1

<400>  1781

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  1782
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human NME7

<400>  1782
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

ttttttcctt caagtggagg ttgtgggccg gcaaacactg ctaaatttac taattgtacc      720

tgttgcattg ttaaacccca tgctgtcagt gaaggactgt tgggaaagat cctgatggct      780

atccgagatg caggttttga aatctcagct atgcagatgt tcaatatgga tcgggttaat      840

gttgaggaat tctatgaagt ttataaagga gtagtgaccg aatatcatga catggtgaca      900

gaaatgtatt ctggcccttg tgtagcaatg gagattcaac agaataatgc tacaaagaca      960

tttcgagaat tttgtggacc tgctgatcct gaaattgccc ggcatttacg ccctggaact     1020

ctcagagcaa tctttggtaa aactaagatc cagaatgctg ttcactgtac tgatctgcca     1080

gaggatggcc tattagaggt tcaatacttc ttcaagatct tggataatta g              1131


<210>  1783
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7

<400>  1783

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  1784
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  [00947]	hC2 CD28 1XX (CD28 h/tm)

<400>  1784
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact aagcacctgt gtccttctcc actgttcccc      840

ggccctagca agcctttctg ggtcctggtg gtggtgggcg gagtgctggc ctgctacagc      900

ctgctggtga ccgtggcctt tatcatcttc tgggtgagga gtaagaggag caggctcctg      960

cacagtgact acatgaacat gactcctaga agacctgggc ctaccagaaa gcattaccag     1020

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgttcaatg aactgcagaa agataagatg     1260

gcggaggcct tcagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggccttttcc agggtctcag tacagccacc aaggacacct tcgacgccct tcacatgcag     1380

gccctgcccc ctcgctgata a                                               1401


<210>  1785
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [00947]	hC2 CD28 1XX (CD28 h/tm)

<400>  1785

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Lys His 
            260                 265                 270         


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
        275                 280                 285             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    290                 295                 300                 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
305                 310                 315                 320 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                325                 330                 335     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            340                 345                 350         


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  1786
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1786
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1787
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1787

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  1788
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hMNC2 scFV

<400>  1788
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acgaact                                          747


<210>  1789
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hMNC2 scFV

<400>  1789

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  1790
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge region (811-855)

<400>  1790
aagcacctgt gtccttctcc actgttcccc ggccctagca agcct                       45


<210>  1791
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge region (811-855)

<400>  1791

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15  


<210>  1792
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain (856-936)

<400>  1792
ttctgggtcc tggtggtggt gggcggagtg ctggcctgct acagcctgct ggtgaccgtg       60

gcctttatca tcttctgggt g                                                 81


<210>  1793
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain (856-936)

<400>  1793

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  1794
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 (937-1059)

<400>  1794
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc tagaagacct       60

gggcctacca gaaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1795
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 (937-1059)

<400>  1795

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  1796
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta 1XX

<400>  1796
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1797
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta 1XX

<400>  1797

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  1798
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10N CD28 1XX (CD28 h/tm)

<400>  1798
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatcagacag      180

gcccctggca aaggcctgga atgggtggcg tctattggca gagccggcag cacctactac      240

agcgactctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtttct      420

agcggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga aattgtgctg      480

acacagagcc ccgccacact gtcactttct ccaggcgaaa gagccacact gagctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc aagctcctcg gctgctgatc tattgggcca gcacaagaga gagcggcatc      660

cctgccagat tttctggcag cggctctggc accgatttca ccctgaccat aagcagcctg      720

gaacctgagg acttcgccgt gtattactgc caccagtacc tgagcagcct gacctttggc      780

ggaggcacca aggtggaaat caagcggaag cacctgtgtc cttctccact gttccccggc      840

cctagcaagc ctttctgggt cctggtggtg gtgggcggag tgctggcctg ctacagcctg      900

ctggtgaccg tggcctttat catcttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tcctagaaga cctgggccta ccagaaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1080

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgagaagga agaaccctca ggaaggcctg ttcaatgaac tgcagaaaga taagatggcg     1260

gaggccttca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1320

cttttccagg gtctcagtac agccaccaag gacaccttcg acgcccttca catgcaggcc     1380

ctgccccctc gctgataa                                                   1398


<210>  1799
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h20A10N CD28 1XX (CD28 h/tm)

<400>  1799

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
                165                 170                 175     


Leu Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Ile Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460                 


<210>  1800
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1800
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  1801
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 leader sequence

<400>  1801

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  1802
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  h20A10N scFV

<400>  1802
caggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtggcgtct attggcagag ccggcagcac ctactacagc      180

gactctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtttctagc      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgaaat tgtgctgaca      420

cagagccccg ccacactgtc actttctcca ggcgaaagag ccacactgag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccaag ctcctcggct gctgatctat tgggccagca caagagagag cggcatccct      600

gccagatttt ctggcagcgg ctctggcacc gatttcaccc tgaccataag cagcctggaa      660

cctgaggact tcgccgtgta ttactgccac cagtacctga gcagcctgac ctttggcgga      720

ggcaccaagg tggaaatcaa gcgg                                             744


<210>  1803
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h20A10N scFV

<400>  1803

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  1804
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge region (811-855)

<400>  1804
aagcacctgt gtccttctcc actgttcccc ggccctagca agcct                       45


<210>  1805
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge region (811-855)

<400>  1805

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15  


<210>  1806
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain (856-936)

<400>  1806
ttctgggtcc tggtggtggt gggcggagtg ctggcctgct acagcctgct ggtgaccgtg       60

gcctttatca tcttctgggt g                                                 81


<210>  1807
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain (856-936)

<400>  1807

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  1808
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 (937-1059)

<400>  1808
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc tagaagacct       60

gggcctacca gaaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1809
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 (937-1059)

<400>  1809

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  1810
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta 1XX

<400>  1810
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc cagggtctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgctgat aa                         342


<210>  1811
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta 1XX

<400>  1811

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  1812
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 3C2B1 scFv sequence

<400>  1812
gaggtgcagc tggtggaatc cggcggagga ctcgtgaagc ccggcggcag cctgcggctg       60

agctgcgccg cttctggcat caccttcagc acctacacca tgagctgggt cagacaggcc      120

cctggcaagg gcctggaatg ggtggccaca atctctacag gcggagataa gacctactac      180

agcgacagcg tgaaaggcag attcaccatc tctagagata atgccaagaa caccctgtac      240

ctgcaaatga acagcctgcg ggccgaggac accgccgtgt actattgtgc tagaggcaca      300

acagccatgt actactacgc catggactac tggggccagg gcacaaccgt gaccgtgtcc      360

agcggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga tatcgtgctg      420

acccagagcc ctgcttctct ggccgtgtcc ccaggccagc gggccacaat cacctgtaga      480

gccagcaagt ccatcagcac cagcgactac aactacatcc actggtatca gcagaaacct      540

ggccaacctc ctaagctgct catctacctg gccagcaacc tggaaagcgg cgtgcccgcc      600

agattcagcg gatctggctc tggcaccgac ttcaccctga caattagccc cgtcgaggcc      660

gaggacgccg ccacctacta ctgccagcac agcagagagc tgcctctgac ctttggcggc      720

ggaacaaagg tggaaatcaa g                                                741


<210>  1813
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C2B1 scFv sequence

<400>  1813

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Gly Asp Lys Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Met Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Ile Ser Thr Ser Asp Tyr Asn Tyr Ile His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Pro Val Glu Ala Glu Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  1814
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized 5C6F3 scFv sequence

<400>  1814
gaggtgcagc tggtggaaag cggcggcgga ctggtgaaac ccggcggcag cctgagactc       60

tcttgtgccg ccagcggatt tacattcagc acctacgcca tgagctgggt gcggcaggcc      120

cctggcaagg gcctggaatg ggtcgccgct atctccaacg gcggaggcta cacctactat      180

cctgattctc tgaagggcag gttcaccatc agcagagata acagcaagaa taccctgtac      240

ctgcaaatga actctctgcg ggccgaggac accgccgtgt actactgcgc tagaagatac      300

tacgaccact acttcgacta ctggggccag ggcacactgg tgacagtgtc cagcggcggt      360

ggcggaagcg gaggcggtgg ctccggtggc ggaggcagcg atatcgtgat gacccaatct      420

cctagcagcc tgagcgtgtc cccaggcgag cgggccagca tcagctgtag aagctcccag      480

accatcgtgc acagcaacgg caacacctac ctggaatggt atcagcagaa acctggccag      540

agccccaagc tgctgatcta caaggtgtct aatagattca gcggcgtgcc tgatagattt      600

agcggatctg gctccggcac agacttcacc ctgacaattt ctggagttga ggccgaggac      660

gtgggcgtct actactgctt ccaggacagc cacgtgcccc tgaccttcgg cggcggaaca      720

aaggtggaaa tcaag                                                       735


<210>  1815
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 5C6F3 scFv sequence

<400>  1815

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Asp His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Val Ser Pro Gly Glu Arg Ala Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Gly Val Glu Ala Glu Asp Val Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Asp Ser His Val Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  1816
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 5C6F3 Heavy chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1816
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt acctatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcagcc attagtaatg gtggtggtta cacctactat      180

ccagacagtc tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccacgt attactgtgc aagacgttac      300

tatgatcact actttgacta ctggggccaa ggcaccgctc tcacggtctc ctca            354


<210>  1817
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 5C6F3 Heavy chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1817

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Asn Gly Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Asp His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser 
        115             


<210>  1818
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 5C6F3 Light chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1818
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaccattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagggtgg aggctgagga tctgggagtt tattactgct ttcaagattc acatgttcct      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  1819
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 5C6F3 Light chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1819

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Asp 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  1820
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C2B1 Heavy chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1820
gaagtgatgc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggaat cactttcagt acctatacca tgtcgtgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtactg gtggtgataa aacctactat      180

tcagacagtg tgaagggtcg attcaccatc tccagagaca atgccaagaa caacctgtac      240

ctccaaatga gcagtctgag gtctgaggac acggccttgt attactgtgc aaggggaacc      300

acggctatgt attactatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  1821
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C2B1 Heavy chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1821

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Gly Asp Lys Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Met Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  1822
<211>  332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C2B1 Light chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1822
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtatcagt acatctgact ataattatat tcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

gggtccctgc caggttcagt ggcagtgggt ctgggacaga cttcaccctc aacatccatc      240

ctgtggagga agaagatgct gcaacctatt actgtcagca cagtagggag cttcctctca      300

cgttcggtgc tgggaccaag ctggagctga aa                                    332


<210>  1823
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse antibody 3C2B1 Light chain sequence

       Signal peptide-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  1823

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Thr Ser 
            20                  25                  30          


Asp Tyr Asn Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  1824
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10MR scFV

<400>  1824
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgaca      420

cagagccctt ctagcctggc cgtgtctctg ggagagagag ccacaatcag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggacagt ctcccaagct gctgatctac tgggccagca ccagagaaag cggcgtgccc      600

gatagattca caggctctgg cagcggcacc gacttcaccc tgacaattag cagtctgcag      660

gccgaggacg tggccgtgta ctactgtcac cagtacctga gcagcctgac ctttggcggc      720

ggaacaaagg tggaaatcaa gaga                                             744


<210>  1825
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10MR scFV

<400>  1825

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg 
                245             


<210>  1826
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10MRT scFV

<400>  1826
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgaca      420

cagagccctt ctagcctggc cgtgtctctg ggagagagag ccacaatcag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggacagt ctcccaagct gctgatctac tgggccagca ccagagaaag cggcgtgccc      600

gatagattca caggctctgg cagcggcacc gacttcaccc tgacaattag cagtctgcag      660

gccgaggacg tggccgtgta ctactgtcac cagtacctga gcagcctgac ctttggcggc      720

ggaacaaagg tggaaatcaa gagaacc                                          747


<210>  1827
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10MRT scFV

<400>  1827

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  1828
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10C2-R scFV

<400>  1828
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat tgtgctgacc      420

cagtctccag cctccttggc cgtgtctcca ggacagaggg ccaccatcac ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaaa      540

ccaggacaac ctcctaaact cctgatttac tgggccagca ccagagaaag cggggtccca      600

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      660

gctaatgata ctgcaaatta ttactgtcac cagtacctga gcagcctgac cttcggcgga      720

gggaccaagg tggagatcaa a                                                741


<210>  1829
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10C2-R scFV

<400>  1829

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr 
    210                 215                 220                 


Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  1830
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10C2RT scFV

<400>  1830
gaggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggttgcctct atcggcagag ccggcagcac ctactacagc      180

gattctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtcagctct      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat tgtgctgacc      420

cagtctccag cctccttggc cgtgtctcca ggacagaggg ccaccatcac ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaaa      540

ccaggacaac ctcctaaact cctgatttac tgggccagca ccagagaaag cggggtccca      600

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      660

gctaatgata ctgcaaatta ttactgtcac cagtacctga gcagcctgac cttcggcgga      720

gggaccaagg tggagatcaa acgaacc                                          747


<210>  1831
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10C2RT scFV

<400>  1831

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr 
    210                 215                 220                 


Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  1832
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10N-R scFV

<400>  1832
caggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtggcgtct attggcagag ccggcagcac ctactacagc      180

gactctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtttctagc      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgaaat tgtgctgaca      420

cagagccccg ccacactgtc actttctcca ggcgaaagag ccacactgag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccaag ctcctcggct gctgatctat tgggccagca caagagagag cggcatccct      600

gccagatttt ctggcagcgg ctctggcacc gatttcaccc tgaccataag cagcctggaa      660

cctgaggact tcgccgtgta ttactgccac cagtacctga gcagcctgac ctttggcgga      720

ggcaccaagg tggaaatcaa g                                                741


<210>  1833
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10N-R scFV

<400>  1833

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  1834
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10NRT scFV

<400>  1834
caggtgcagc tggttgaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc acatacgcca tgagctggat cagacaggcc      120

cctggcaaag gcctggaatg ggtggcgtct attggcagag ccggcagcac ctactacagc      180

gactctgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      240

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgccag aggacccatc      300

tacaacgact acgacgagtt cgcctattgg ggccagggca cactggtcac agtttctagc      360

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgaaat tgtgctgaca      420

cagagccccg ccacactgtc actttctcca ggcgaaagag ccacactgag ctgcaagagc      480

agccagagcg tgctgtactc cagcaaccag aagaactacc tggcctggta tcagcagaag      540

cccggccaag ctcctcggct gctgatctat tgggccagca caagagagag cggcatccct      600

gccagatttt ctggcagcgg ctctggcacc gatttcaccc tgaccataag cagcctggaa      660

cctgaggact tcgccgtgta ttactgccac cagtacctga gcagcctgac ctttggcgga      720

ggcaccaagg tggaaatcaa gcggacc                                          747


<210>  1835
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10NRT scFV

<400>  1835

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ser 
145                 150                 155                 160 


Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 


Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg Thr 
                245                 


<210>  1836
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6+R scFV

<400>  1836
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgaaattgtg      420

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctcacctgc      480

agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc      540

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      600

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      720

gaaattaaaa ga                                                          732


<210>  1837
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNE6+R scFV

<400>  1837

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  1838
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6+RT scFV

<400>  1838
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aggtatggca tgagctgggt ccgccaggct      120

ccagggaaga ggctggagtg ggtctcaacc attagtggcg gaggcaccta catatactac      180

ccagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtac cagagataac      300

tatggccgca actatgatta tggcatggat tattggggcc agggcaccct ggtgaccgtg      360

agcagcggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgaaattgtg      420

ttgacacagt ctccagccac cctgtctttg tctccagggg aaagagccac cctcacctgc      480

agcgccacca gcagtgttag ctacatccac tggtaccaac agaggcctgg ccagagcccc      540

aggctcctca tctatagcac ctccaacctg gccagcggca tcccagccag gttcagtggc      600

agtgggtctg ggagcgacta cactctcacc atcagcagcc tagagcctga agattttgca      660

gtttattact gtcagcagcg tagcagctcc cctttcacct ttggcagcgg caccaaagtg      720

gaaattaaaa gaacc                                                       735


<210>  1839
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNE6+RT scFV

<400>  1839

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Tyr Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys Arg Thr 
                245 


<210>  1840
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2-T scFV

<400>  1840
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa acga                                             744


<210>  1841
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNC2-T scFV

<400>  1841

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Arg 
                245             


<210>  1842
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2-RT scFV

<400>  1842
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt ggctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaacc attagtagtg gcggaaccta catatactac      180

cccgactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagacttggg      300

ggggataatt actacgaata cttcgatgtc tggggcaaag ggaccacggt caccgtctcc      360

tccggcggtg gcggatccgg cggtggcgga tccggcggtg gcggatccga cattgtgctg      420

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaga      480

gccagtaaga gtgtcagtac cagcggatac tcctacatgc actggtatca gcagaaacca      540

ggacaacctc ctaaactcct gatttacctg gcatccaatc tggagagcgg ggtcccagcc      600

aggttcagcg gcagtgggtc tgggaccgat ttcaccctca caattaatcc tgtggaagct      660

aatgatactg caaattatta ctgtcagcac agtagggagc tgcctttcac attcggcgga      720

gggaccaagg tggagatcaa a                                                741


<210>  1843
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNC2-RT scFV

<400>  1843

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Thr Ala 
    210                 215                 220                 


Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  1844
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10-CAR T-28-28-3z

<400>  1844
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagaagcac ctgtgtcctt ctccactgtt ccccggccct      840

agcaagcctt tctgggtcct ggtggtggtg ggcggagtgc tggcctgcta cagcctgctg      900

gtgaccgtgg cctttatcat cttctgggtg aggagtaaga ggagcaggct cctgcacagt      960

gactacatga acatgactcc tagaagacct gggcctacca gaaagcatta ccagccctat     1020

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1080

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1140

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1200

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1260

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1320

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1380

ccccctcgct gataa                                                      1395


<210>  1845
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10-CAR T-28-28-3z

<400>  1845

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Lys His Leu Cys 
            260                 265                 270         


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  1846
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10-CAR T-28-28-3z

<400>  1846
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaag cacctgtgtc cttctccact gttccccggc      840

cctagcaagc ctttctgggt cctggtggtg gtgggcggag tgctggcctg ctacagcctg      900

ctggtgaccg tggcctttat catcttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tcctagaaga cctgggccta ccagaaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1080

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1260

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1320

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1380

ctgccccctc gctgataa                                                   1398


<210>  1847
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10-CAR T-28-28-3z

<400>  1847

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460                 


<210>  1848
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10-CAR T-28-28-3z-1XX

<400>  1848
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagaagcac ctgtgtcctt ctccactgtt ccccggccct      840

agcaagcctt tctgggtcct ggtggtggtg ggcggagtgc tggcctgcta cagcctgctg      900

gtgaccgtgg cctttatcat cttctgggtg aggagtaaga ggagcaggct cctgcacagt      960

gactacatga acatgactcc tagaagacct gggcctacca gaaagcatta ccagccctat     1020

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1080

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1140

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1200

agaaggaaga accctcagga aggcctgttc aatgaactgc agaaagataa gatggcggag     1260

gccttcagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1320

ttccagggtc tcagtacagc caccaaggac accttcgacg cccttcacat gcaggccctg     1380

ccccctcgct gataa                                                      1395


<210>  1849
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu20A10-CAR T-28-28-3z-1XX

<400>  1849

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Arg 
                85                  90                  95      


Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Ile Met Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
225                 230                 235                 240 


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Lys His Leu Cys 
            260                 265                 270         


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  1850
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10-CAR T-28-28-3z-1XX

<400>  1850
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaag cacctgtgtc cttctccact gttccccggc      840

cctagcaagc ctttctgggt cctggtggtg gtgggcggag tgctggcctg ctacagcctg      900

ctggtgaccg tggcctttat catcttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tcctagaaga cctgggccta ccagaaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1080

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgagaagga agaaccctca ggaaggcctg ttcaatgaac tgcagaaaga taagatggcg     1260

gaggccttca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1320

cttttccagg gtctcagtac agccaccaag gacaccttcg acgcccttca catgcaggcc     1380

ctgccccctc gctgataa                                                   1398


<210>  1851
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu20A10-CAR T-28-28-3z-1XX

<400>  1851

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Ser Ile Gly Arg Ala Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Pro Ile Tyr Asn Asp Tyr Asp Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
                165                 170                 175     


Ile Thr Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val 
225                 230                 235                 240 


Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys His Gln Tyr Leu Ser Ser 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Lys His Leu 
            260                 265                 270         


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
        275                 280                 285             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    290                 295                 300                 


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
305                 310                 315                 320 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
                325                 330                 335     


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460                 


<210>  1852
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6R

<400>  1852
gaggtgcagc tggtggaatc tggcggagga ctggtcaagc ctggaggcag cctgagactg       60

agctgcgccg ccagcggctt cacattcagc agctacggca tgagctgggt gcggcaggcc      120

cctggcaagg gcctggaatg ggtcagcacc atcagcaacg gcggaagaca caccttctac      180

cccgacagcg tgaagggcag attcaccatc tcaagagata acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagacagacc      300

ggcacagagg gctggttcgc ctactggggc cagggcaccc tggtgaccgt gtccagcggc      360

ggtggcggaa gcggaggcgg tggctccggt ggcggaggca gcgacatcgt gatgacccag      420

acccctctgt ctctgagcgt gacccctggc cagcctgcca gcatctcttg taaaagcagc      480

cagagcctgc tggacagcga cggcaagacc tacctgaact ggtacctgca gaagcccggc      540

caaagccctc agctgctgat ctacctggtg tccaagctgg atagcggtgt tcctgataga      600

ttcagcggat ctggcagcgg caccgacttc accctgaaga tcagcagagt ggaagccgag      660

gacgtgggcg tgtactactg ctggcagggc acacacttcc cccagacatt cggccagggc      720

accaaggtgg aaatcaagcg g                                                741


<210>  1853
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6R

<400>  1853

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Lys 
            180                 185                 190         


Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg 
                245         


<210>  1854
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6RT full sequence

<400>  1854
gaggtgcagc tggtggaatc tggcggagga ctggtcaagc ctggaggcag cctgagactg       60

agctgcgccg ccagcggctt cacattcagc agctacggca tgagctgggt gcggcaggcc      120

cctggcaagg gcctggaatg ggtcagcacc atcagcaacg gcggaagaca caccttctac      180

cccgacagcg tgaagggcag attcaccatc tcaagagata acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagacagacc      300

ggcacagagg gctggttcgc ctactggggc cagggcaccc tggtgaccgt gtccagcggc      360

ggtggcggaa gcggaggcgg tggctccggt ggcggaggca gcgacatcgt gatgacccag      420

acccctctgt ctctgagcgt gacccctggc cagcctgcca gcatctcttg taaaagcagc      480

cagagcctgc tggacagcga cggcaagacc tacctgaact ggtacctgca gaagcccggc      540

caaagccctc agctgctgat ctacctggtg tccaagctgg atagcggtgt tcctgataga      600

ttcagcggat ctggcagcgg caccgacttc accctgaaga tcagcagagt ggaagccgag      660

gacgtgggcg tgtactactg ctggcagggc acacacttcc cccagacatt cggccagggc      720

accaaggtgg aaatcaagcg gacc                                             744


<210>  1855
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6RT full sequence

<400>  1855

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
    130                 135                 140                 


Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Val Ser Lys 
            180                 185                 190         


Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
    210                 215                 220                 


Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr 
                245             


<210>  1856
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6-CAR T-28-28-3z

<400>  1856
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aaagcacctg tgtccttctc cactgttccc cggccctagc      840

aagcctttct gggtcctggt ggtggtgggc ggagtgctgg cctgctacag cctgctggtg      900

accgtggcct ttatcatctt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactcctag aagacctggg cctaccagaa agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1260

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1320

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1380

cctcgctgat aa                                                         1392


<210>  1857
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6-CAR T-28-28-3z

<400>  1857

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  1858
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6-CAR T-28-28-3z

<400>  1858
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gaagcacctg tgtccttctc cactgttccc cggccctagc      840

aagcctttct gggtcctggt ggtggtgggc ggagtgctgg cctgctacag cctgctggtg      900

accgtggcct ttatcatctt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactcctag aagacctggg cctaccagaa agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1260

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1320

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1380

cctcgctgat aa                                                         1392


<210>  1859
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6-CAR T-28-28-3z

<400>  1859

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  1860
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6-CAR T-28-28-3z-1XX

<400>  1860
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aaagcacctg tgtccttctc cactgttccc cggccctagc      840

aagcctttct gggtcctggt ggtggtgggc ggagtgctgg cctgctacag cctgctggtg      900

accgtggcct ttatcatctt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactcctag aagacctggg cctaccagaa agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgttcaat gaactgcaga aagataagat ggcggaggcc     1260

ttcagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggccttttc     1320

cagggtctca gtacagccac caaggacacc ttcgacgccc ttcacatgca ggccctgccc     1380

cctcgctgat aa                                                         1392


<210>  1861
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mu25E6-CAR T-28-28-3z-1XX

<400>  1861

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Leu Cys Val Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  1862
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6-CAR T-28-28-3z-1XX

<400>  1862
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gaagcacctg tgtccttctc cactgttccc cggccctagc      840

aagcctttct gggtcctggt ggtggtgggc ggagtgctgg cctgctacag cctgctggtg      900

accgtggcct ttatcatctt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactcctag aagacctggg cctaccagaa agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgttcaat gaactgcaga aagataagat ggcggaggcc     1260

ttcagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggccttttc     1320

cagggtctca gtacagccac caaggacacc ttcgacgccc ttcacatgca ggccctgccc     1380

cctcgctgat aa                                                         1392


<210>  1863
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu25E6-CAR T-28-28-3z-1XX

<400>  1863

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Asn Gly Gly Arg His Thr Phe 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gln Thr Gly Thr Glu Gly Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile 
                165                 170                 175     


Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        195                 200                 205             


Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Gln 
                245                 250                 255     


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  1864
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNC2-CAR T-28-28-3z-1XX

<400>  1864
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccaa gcacctgtgt ccttctccac tgttccccgg ccctagcaag      900

cctttctggg tcctggtggt ggtgggcgga gtgctggcct gctacagcct gctggtgacc      960

gtggccttta tcatcttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     1020

atgaacatga ctcctagaag acctgggcct accagaaagc attaccagcc ctatgcccca     1080

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gttcaatgaa ctgcagaaag ataagatggc ggaggccttc     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg ccttttccag     1380

ggtctcagta cagccaccaa ggacaccttc gacgcccttc acatgcaggc cctgccccct     1440

cgctgataa                                                             1449


<210>  1865
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMNC2-CAR T-28-28-3z-1XX

<400>  1865

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys 
    130                 135                 140                 


Thr Thr Pro Pro Ser Val Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Val Ile Thr Gln Ser Thr Ala Ser 
                165                 170                 175     


Leu Gly Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            180                 185                 190         


Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln 
        195                 200                 205             


Arg Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
    210                 215                 220                 


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr 
                245                 250                 255     


Tyr Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Lys His 
        275                 280                 285             


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
    290                 295                 300                 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
305                 310                 315                 320 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
                325                 330                 335     


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            340                 345                 350         


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        355                 360                 365             


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  1866
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2-CAR T-28-28-3z-1XX

<400>  1866
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact aagcacctgt gtccttctcc actgttcccc      840

ggccctagca agcctttctg ggtcctggtg gtggtgggcg gagtgctggc ctgctacagc      900

ctgctggtga ccgtggcctt tatcatcttc tgggtgagga gtaagaggag caggctcctg      960

cacagtgact acatgaacat gactcctaga agacctgggc ctaccagaaa gcattaccag     1020

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgttcaatg aactgcagaa agataagatg     1260

gcggaggcct tcagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggccttttcc agggtctcag tacagccacc aaggacacct tcgacgccct tcacatgcag     1380

gccctgcccc ctcgctgata a                                               1401


<210>  1867
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNC2-CAR T-28-28-3z-1XX

<400>  1867

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Gly Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Leu Gly Gly Asp Asn Tyr Tyr Glu Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser 
            180                 185                 190         


Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro 
                245                 250                 255     


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Lys His 
            260                 265                 270         


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
        275                 280                 285             


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    290                 295                 300                 


Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
305                 310                 315                 320 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                325                 330                 335     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            340                 345                 350         


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  1868
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE6-CAR T-28-28-3z-1XX

<400>  1868
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaaagcacct gtgtccttct ccactgttcc ccggccctag caagcctttc      840

tgggtcctgg tggtggtggg cggagtgctg gcctgctaca gcctgctggt gaccgtggcc      900

tttatcatct tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      960

atgactccta gaagacctgg gcctaccaga aagcattacc agccctatgc cccaccacgc     1020

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1080

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1140

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1200

cctcaggaag gcctgttcaa tgaactgcag aaagataaga tggcggaggc cttcagtgag     1260

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggcctttt ccagggtctc     1320

agtacagcca ccaaggacac cttcgacgcc cttcacatgc aggccctgcc ccctcgctga     1380

taa                                                                   1383


<210>  1869
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muMNE6-CAR T-28-28-3z-1XX

<400>  1869

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Val Val Glu Ser Gly Gly Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Val Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ala Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr His Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Glu 
                165                 170                 175     


Val Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Phe Gln Gln Arg Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Tyr 
    210                 215                 220                 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Leu Glu Ile Lys Lys His Leu Cys Pro Ser Pro Leu 
            260                 265                 270         


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  1870
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6-CAR T-28-28-3z-1XX

<400>  1870
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaaagcacct gtgtccttct ccactgttcc ccggccctag caagcctttc      840

tgggtcctgg tggtggtggg cggagtgctg gcctgctaca gcctgctggt gaccgtggcc      900

tttatcatct tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      960

atgactccta gaagacctgg gcctaccaga aagcattacc agccctatgc cccaccacgc     1020

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1080

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1140

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1200

cctcaggaag gcctgttcaa tgaactgcag aaagataaga tggcggaggc cttcagtgag     1260

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggcctttt ccagggtctc     1320

agtacagcca ccaaggacac cttcgacgcc cttcacatgc aggccctgcc ccctcgctga     1380

taa                                                                   1383


<210>  1871
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huMNE6-CAR T-28-28-3z-1XX

<400>  1871

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Arg Leu Glu Trp Val Ser Thr Ile Ser Gly Gly Gly Thr Tyr Ile Tyr 
65                  70                  75                  80  


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Asp Asn Tyr Gly Arg Asn Tyr Asp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg 
                165                 170                 175     


Ala Thr Leu Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Ser Thr 
        195                 200                 205             


Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Phe Thr Phe Gly 
                245                 250                 255     


Ser Gly Thr Lys Val Glu Ile Lys Lys His Leu Cys Pro Ser Pro Leu 
            260                 265                 270         


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  1872
<211>  2263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNC2-28-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1872
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtcc agctggagga gtcaggggga ggcttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg attcactttc agtggctatg ccatgtcttg ggttcgccag      180

actccggaga agaggctgga gtgggtcgca accattagta gtggtggtac ttatatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaggtctgag gacacggcca tgtattactg tgcaagactt      360

gggggggata attactacga atacttcgat gtctggggcg cagggaccac ggtcaccgtc      420

tcctccgcca aaacgacacc cccatctgtc tatggcggtg gcggatccgg cggtggcgga      480

tccggcggtg gcggatccga cattgtgatc acacagtcta cagcttcctt aggtgtatct      540

ctggggcaga gggccaccat ctcatgcagg gccagcaaaa gtgtcagtac atctggctat      600

agttatatgc actggtacca acagagacca ggacagccac ccaaactcct catctatctt      660

gcatccaacc tagaatctgg ggtccctgcc aggttcagtg gcagtgggtc tgggacagac      720

ttcaccctca acatccatcc tgtggaggag gaggatgctg caacctatta ctgtcagcac      780

agtagggagc ttccgttcac gttcggaggg gggaccaagc tggagataaa acgggctgat      840

gctgcaccaa ctgtatccaa gcacctgtgt ccttctccac tgttccccgg ccctagcaag      900

cctttctggg tcctggtggt ggtgggcgga gtgctggcct gctacagcct gctggtgacc      960

gtggccttta tcatcttctg ggtgaggagt aagaggagca ggctcctgca cagtgactac     1020

atgaacatga ctcctagaag acctgggcct accagaaagc attaccagcc ctatgcccca     1080

ccacgcgact tcgcagccta tcgctccaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gttcaatgaa ctgcagaaag ataagatggc ggaggccttc     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg ccttttccag     1380

ggtctcagta cagccaccaa ggacaccttc gacgcccttc acatgcaggc cctgccccct     1440

cgctgataag tttaaactgc cagaacattt ctctggccta actggccggt accggcttca     1500

ttttttccat ttactgcaga ggcttcattt tttccattta ctgcagaggc ttcatttttt     1560

ccatttactg cagaactagt taggcgtgta cggtgggagg cctatataag cagagctcgt     1620

ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga     1680

caccgggacc gatccagcct cgagagaccc aatgctagcc accatggcct taccagtgac     1740

cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc aggccgtact tcggcaagct     1800

ggaaagcaag ctgagcgtga tccggaacct gaacgaccag gtgctgttca tcgatcaggg     1860

caacagaccc ctgttcgagg acatgaccga cagcgactgc agagacaacg cccctcggac     1920

catcttcatc atcagcatgt acaaggacag ccagcctaga ggcatggccg tgaccatctc     1980

tgtgaagtgc gagaagatca gcaccctgag ctgcgagaac aagatcatca gcttcaaaga     2040

gatgaacccg ccggacaaca tcaaggacac caagagcgac atcatattct tccagcggag     2100

cgtgcccggc cacgacaaca agatgcagtt tgagagcagc agctacgagg gctacttcct     2160

ggcctgcgag aaagagcggg acctgttcaa gctgatcctg aagaaagagg acgaactggg     2220

cgaccgcagc atcatgttca ccgtgcagaa cgaggactga taa                       2263


<210>  1873
<211>  2215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNC2-28-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1873
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtggctatg ccatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca accattagta gtggcggaac ctacatatac      240

taccccgact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaactcactg      300

tatctgcaaa tgaacagcct gagagccgag gacacggccg tgtattactg tgcgagactt      360

gggggggata attactacga atacttcgat gtctggggca aagggaccac ggtcaccgtc      420

tcctccggcg gtggcggatc cggcggtggc ggatccggcg gtggcggatc cgacattgtg      480

ctgacccagt ctccagcctc cttggccgtg tctccaggac agagggccac catcacctgc      540

agagccagta agagtgtcag taccagcgga tactcctaca tgcactggta tcagcagaaa      600

ccaggacaac ctcctaaact cctgatttac ctggcatcca atctggagag cggggtccca      660

gccaggttca gcggcagtgg gtctgggacc gatttcaccc tcacaattaa tcctgtggaa      720

gctaatgata ctgcaaatta ttactgtcag cacagtaggg agctgccttt cacattcggc      780

ggagggacca aggtggagat caaacgaact aagcacctgt gtccttctcc actgttcccc      840

ggccctagca agcctttctg ggtcctggtg gtggtgggcg gagtgctggc ctgctacagc      900

ctgctggtga ccgtggcctt tatcatcttc tgggtgagga gtaagaggag caggctcctg      960

cacagtgact acatgaacat gactcctaga agacctgggc ctaccagaaa gcattaccag     1020

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc     1080

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     1140

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1200

aagccgagaa ggaagaaccc tcaggaaggc ctgttcaatg aactgcagaa agataagatg     1260

gcggaggcct tcagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggccttttcc agggtctcag tacagccacc aaggacacct tcgacgccct tcacatgcag     1380

gccctgcccc ctcgctgata agtttaaact gccagaacat ttctctggcc taactggccg     1440

gtaccggctt cattttttcc atttactgca gaggcttcat tttttccatt tactgcagag     1500

gcttcatttt ttccatttac tgcagaacta gttaggcgtg tacggtggga ggcctatata     1560

agcagagctc gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac     1620

ctccatagaa gacaccggga ccgatccagc ctcgagagac ccaatgctag ccaccatggc     1680

cttaccagtg accgccttgc tcctgccgct ggccttgctg ctccacgccg ccaggccgta     1740

cttcggcaag ctggaaagca agctgagcgt gatccggaac ctgaacgacc aggtgctgtt     1800

catcgatcag ggcaacagac ccctgttcga ggacatgacc gacagcgact gcagagacaa     1860

cgcccctcgg accatcttca tcatcagcat gtacaaggac agccagccta gaggcatggc     1920

cgtgaccatc tctgtgaagt gcgagaagat cagcaccctg agctgcgaga acaagatcat     1980

cagcttcaaa gagatgaacc cgccggacaa catcaaggac accaagagcg acatcatatt     2040

cttccagcgg agcgtgcccg gccacgacaa caagatgcag tttgagagca gcagctacga     2100

gggctacttc ctggcctgcg agaaagagcg ggacctgttc aagctgatcc tgaagaaaga     2160

ggacgaactg ggcgaccgca gcatcatgtt caccgtgcag aacgaggact gataa          2215


<210>  1874
<211>  2197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muMNE6-28-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1874
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtga aggtggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg tagtctctgg attcactttc agtagatatg gcatgtcttg ggttcgccag      180

actccaggca agaggctgga gtgggtcgca accattagtg gtggcggtac ttacatctac      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tacctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatcactg tacaagggat      360

aactacggta ggaactacga ctacggtatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctcag gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atcccaaatt      480

gttctcaccc agtctccagc aatcatgtct gcatctccag gggaggaggt caccctaacc      540

tgcagtgcca cctcaagtgt aagttacata cactggttcc agcagaggcc aggcacttct      600

cccaaactct ggatttatag cacatccaac ctggcttctg gagtccctgt tcgcttcagt      660

ggcagtggat atgggacctc ttactctctc acaatcagcc gaatggaggc tgaagatgct      720

gccacttatt actgccagca aaggagtagt tccccattca cgttcggctc ggggacaaag      780

ttggaaataa aaaagcacct gtgtccttct ccactgttcc ccggccctag caagcctttc      840

tgggtcctgg tggtggtggg cggagtgctg gcctgctaca gcctgctggt gaccgtggcc      900

tttatcatct tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      960

atgactccta gaagacctgg gcctaccaga aagcattacc agccctatgc cccaccacgc     1020

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1080

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1140

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1200

cctcaggaag gcctgttcaa tgaactgcag aaagataaga tggcggaggc cttcagtgag     1260

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggcctttt ccagggtctc     1320

agtacagcca ccaaggacac cttcgacgcc cttcacatgc aggccctgcc ccctcgctga     1380

taagtttaaa ctgccagaac atttctctgg cctaactggc cggtaccggc ttcatttttt     1440

ccatttactg cagaggcttc attttttcca tttactgcag aggcttcatt ttttccattt     1500

actgcagaac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg     1560

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg     1620

gaccgatcca gcctcgagag acccaatgct agccaccatg gccttaccag tgaccgcctt     1680

gctcctgccg ctggccttgc tgctccacgc cgccaggccg tacttcggca agctggaaag     1740

caagctgagc gtgatccgga acctgaacga ccaggtgctg ttcatcgatc agggcaacag     1800

acccctgttc gaggacatga ccgacagcga ctgcagagac aacgcccctc ggaccatctt     1860

catcatcagc atgtacaagg acagccagcc tagaggcatg gccgtgacca tctctgtgaa     1920

gtgcgagaag atcagcaccc tgagctgcga gaacaagatc atcagcttca aagagatgaa     1980

cccgccggac aacatcaagg acaccaagag cgacatcata ttcttccagc ggagcgtgcc     2040

cggccacgac aacaagatgc agtttgagag cagcagctac gagggctact tcctggcctg     2100

cgagaaagag cgggacctgt tcaagctgat cctgaagaaa gaggacgaac tgggcgaccg     2160

cagcatcatg ttcaccgtgc agaacgagga ctgataa                              2197


<210>  1875
<211>  2197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  huMNE6-28-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1875
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga ggcctggtca agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaggtatg gcatgagctg ggtccgccag      180

gctccaggga agaggctgga gtgggtctca accattagtg gcggaggcac ctacatatac      240

tacccagact cagtgaaggg ccgattcacc atctccagag acaacgccaa gaacaccctg      300

tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg taccagagat      360

aactatggcc gcaactatga ttatggcatg gattattggg gccagggcac cctggtgacc      420

gtgagcagcg gcggtggcgg atccggcggt ggcggatccg gcggtggcgg atccgaaatt      480

gtgttgacac agtctccagc caccctgtct ttgtctccag gggaaagagc caccctcacc      540

tgcagcgcca ccagcagtgt tagctacatc cactggtacc aacagaggcc tggccagagc      600

cccaggctcc tcatctatag cacctccaac ctggccagcg gcatcccagc caggttcagt      660

ggcagtgggt ctgggagcga ctacactctc accatcagca gcctagagcc tgaagatttt      720

gcagtttatt actgtcagca gcgtagcagc tcccctttca cctttggcag cggcaccaaa      780

gtggaaatta aaaagcacct gtgtccttct ccactgttcc ccggccctag caagcctttc      840

tgggtcctgg tggtggtggg cggagtgctg gcctgctaca gcctgctggt gaccgtggcc      900

tttatcatct tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      960

atgactccta gaagacctgg gcctaccaga aagcattacc agccctatgc cccaccacgc     1020

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1080

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1140

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1200

cctcaggaag gcctgttcaa tgaactgcag aaagataaga tggcggaggc cttcagtgag     1260

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggcctttt ccagggtctc     1320

agtacagcca ccaaggacac cttcgacgcc cttcacatgc aggccctgcc ccctcgctga     1380

taagtttaaa ctgccagaac atttctctgg cctaactggc cggtaccggc ttcatttttt     1440

ccatttactg cagaggcttc attttttcca tttactgcag aggcttcatt ttttccattt     1500

actgcagaac tagttaggcg tgtacggtgg gaggcctata taagcagagc tcgtttagtg     1560

aaccgtcaga tcgcctggag acgccatcca cgctgttttg acctccatag aagacaccgg     1620

gaccgatcca gcctcgagag acccaatgct agccaccatg gccttaccag tgaccgcctt     1680

gctcctgccg ctggccttgc tgctccacgc cgccaggccg tacttcggca agctggaaag     1740

caagctgagc gtgatccgga acctgaacga ccaggtgctg ttcatcgatc agggcaacag     1800

acccctgttc gaggacatga ccgacagcga ctgcagagac aacgcccctc ggaccatctt     1860

catcatcagc atgtacaagg acagccagcc tagaggcatg gccgtgacca tctctgtgaa     1920

gtgcgagaag atcagcaccc tgagctgcga gaacaagatc atcagcttca aagagatgaa     1980

cccgccggac aacatcaagg acaccaagag cgacatcata ttcttccagc ggagcgtgcc     2040

cggccacgac aacaagatgc agtttgagag cagcagctac gagggctact tcctggcctg     2100

cgagaaagag cgggacctgt tcaagctgat cctgaagaaa gaggacgaac tgggcgaccg     2160

cagcatcatg ttcaccgtgc agaacgagga ctgataa                              2197


<210>  1876
<211>  2209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu20A10-28-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1876
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaagtga tgctggtgga atctggcggc ggactggtta agcctggcgg atctctgaag      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg gatccggcag      180

acccctgaga agagactgga atgggttgcc agcatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgtgcggaa catcctgtac      300

ctgcagatga gcagcctgcg gagcgaggat accgccatgt actactgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt tacagtttct      420

gctggtggcg gaggatctgg cggaggtgga agcggcggag gcggatccaa tatcatgatg      480

acacagagcc cgagcagcct ggctgtgtct gctggcgaga aagtgaccat gtcctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aagcccggcc agtctcctaa gctgctgatc tactgggcca gcaccagaga aagcggcgtg      660

cccgatagat tcacaggcag cggcagcgga accgacttca ccctgacaat cagctctgtg      720

caggccgaag atctggccgt gtactattgc caccagtacc tgtccagcct gacctttggc      780

gccggaacaa agctggaact gaagaagcac ctgtgtcctt ctccactgtt ccccggccct      840

agcaagcctt tctgggtcct ggtggtggtg ggcggagtgc tggcctgcta cagcctgctg      900

gtgaccgtgg cctttatcat cttctgggtg aggagtaaga ggagcaggct cctgcacagt      960

gactacatga acatgactcc tagaagacct gggcctacca gaaagcatta ccagccctat     1020

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1080

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1140

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1200

agaaggaaga accctcagga aggcctgttc aatgaactgc agaaagataa gatggcggag     1260

gccttcagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1320

ttccagggtc tcagtacagc caccaaggac accttcgacg cccttcacat gcaggccctg     1380

ccccctcgct gataagttta aactgccaga acatttctct ggcctaactg gccggtaccg     1440

gcttcatttt ttccatttac tgcagaggct tcattttttc catttactgc agaggcttca     1500

ttttttccat ttactgcaga actagttagg cgtgtacggt gggaggccta tataagcaga     1560

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     1620

agaagacacc gggaccgatc cagcctcgag agacccaatg ctagccacca tggccttacc     1680

agtgaccgcc ttgctcctgc cgctggcctt gctgctccac gccgccaggc cgtacttcgg     1740

caagctggaa agcaagctga gcgtgatccg gaacctgaac gaccaggtgc tgttcatcga     1800

tcagggcaac agacccctgt tcgaggacat gaccgacagc gactgcagag acaacgcccc     1860

tcggaccatc ttcatcatca gcatgtacaa ggacagccag cctagaggca tggccgtgac     1920

catctctgtg aagtgcgaga agatcagcac cctgagctgc gagaacaaga tcatcagctt     1980

caaagagatg aacccgccgg acaacatcaa ggacaccaag agcgacatca tattcttcca     2040

gcggagcgtg cccggccacg acaacaagat gcagtttgag agcagcagct acgagggcta     2100

cttcctggcc tgcgagaaag agcgggacct gttcaagctg atcctgaaga aagaggacga     2160

actgggcgac cgcagcatca tgttcaccgt gcagaacgag gactgataa                 2209


<210>  1877
<211>  2212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu20A10-28-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1877
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggttga atctggcggc ggacttgtga agcctggcgg atctctgaga      120

ctgagctgtg ccgccagcgg cttcaccttt agcacatacg ccatgagctg ggtccgacag      180

gcccctggaa aaggccttga atgggttgcc tctatcggca gagccggcag cacctactac      240

agcgattctg tgaagggcag attcaccatc agccgggaca acgccaagaa cagcctgtac      300

ctgcagatga actccctgag agccgaggac accgccgtgt actattgtgc cagaggaccc      360

atctacaacg actacgacga gttcgcctat tggggccagg gcacactggt cacagtcagc      420

tctggcggtg gcggaagcgg aggcggtggc tccggtggcg gaggcagcga cattgtgctg      480

acccagtctc cagcctcctt ggccgtgtct ccaggacaga gggccaccat cacctgcaag      540

agcagccaga gcgtgctgta ctccagcaac cagaagaact acctggcctg gtatcagcag      600

aaaccaggac aacctcctaa actcctgatt tactgggcca gcaccagaga aagcggggtc      660

ccagccaggt tcagcggcag tgggtctggg accgatttca ccctcacaat taatcctgtg      720

gaagctaatg atactgcaaa ttattactgt caccagtacc tgagcagcct gaccttcggc      780

ggagggacca aggtggagat caaacgaaag cacctgtgtc cttctccact gttccccggc      840

cctagcaagc ctttctgggt cctggtggtg gtgggcggag tgctggcctg ctacagcctg      900

ctggtgaccg tggcctttat catcttctgg gtgaggagta agaggagcag gctcctgcac      960

agtgactaca tgaacatgac tcctagaaga cctgggccta ccagaaagca ttaccagccc     1020

tatgccccac cacgcgactt cgcagcctat cgctccagag tgaagttcag caggagcgca     1080

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgagaagga agaaccctca ggaaggcctg ttcaatgaac tgcagaaaga taagatggcg     1260

gaggccttca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1320

cttttccagg gtctcagtac agccaccaag gacaccttcg acgcccttca catgcaggcc     1380

ctgccccctc gctgataagt ttaaactgcc agaacatttc tctggcctaa ctggccggta     1440

ccggcttcat tttttccatt tactgcagag gcttcatttt ttccatttac tgcagaggct     1500

tcattttttc catttactgc agaactagtt aggcgtgtac ggtgggaggc ctatataagc     1560

agagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg ttttgacctc     1620

catagaagac accgggaccg atccagcctc gagagaccca atgctagcca ccatggcctt     1680

accagtgacc gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccgtactt     1740

cggcaagctg gaaagcaagc tgagcgtgat ccggaacctg aacgaccagg tgctgttcat     1800

cgatcagggc aacagacccc tgttcgagga catgaccgac agcgactgca gagacaacgc     1860

ccctcggacc atcttcatca tcagcatgta caaggacagc cagcctagag gcatggccgt     1920

gaccatctct gtgaagtgcg agaagatcag caccctgagc tgcgagaaca agatcatcag     1980

cttcaaagag atgaacccgc cggacaacat caaggacacc aagagcgaca tcatattctt     2040

ccagcggagc gtgcccggcc acgacaacaa gatgcagttt gagagcagca gctacgaggg     2100

ctacttcctg gcctgcgaga aagagcggga cctgttcaag ctgatcctga agaaagagga     2160

cgaactgggc gaccgcagca tcatgttcac cgtgcagaac gaggactgat aa             2212


<210>  1878
<211>  2206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mu25E6-8-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1878
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtctggggga gacttagtga agcctggagg gtccctgaaa      120

ctctcctgtg cagcctctgg tttcactttc agtagttatg gaatgtcttg ggttcgccag      180

actccagaca agaggctgga gtgggtcgca accattagta atggtggtag acacaccttc      240

tatccagaca gtgtgaaggg gcgattcacc atctccagag acaatgccaa gaacaccctg      300

tatctgcaaa tgagcagtct gaagtctgag gacacagcca tgtatttatg tgtaagacag      360

actgggacgg agggctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

ggtggcggag gatctggcgg aggtggaagc ggcggaggcg gatccgatgt tgtgatgacc      480

cagactccac tcactttgtc ggttaccatt ggacaaccag cctccatctc ttgcaagtca      540

agtcagagcc tcttagatag tgatggaaag acatatttga attggttgtt acagaggcca      600

ggccagtctc caaagcgcct aatctatctg gtgtctaaac tggactctgg agtccctgac      660

aggttcactg gcagtggatc agggacagat ttcacactga aaatcagcag agtggaggct      720

gaggatttgg gagtttatta ttgctggcaa ggtacacatt ttcctcagac gttcggtgga      780

ggcaccaagc tggaaatcaa aaagcacctg tgtccttctc cactgttccc cggccctagc      840

aagcctttct gggtcctggt ggtggtgggc ggagtgctgg cctgctacag cctgctggtg      900

accgtggcct ttatcatctt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactcctag aagacctggg cctaccagaa agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgttcaat gaactgcaga aagataagat ggcggaggcc     1260

ttcagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggccttttc     1320

cagggtctca gtacagccac caaggacacc ttcgacgccc ttcacatgca ggccctgccc     1380

cctcgctgat aagtttaaac tgccagaaca tttctctggc ctaactggcc ggtaccggct     1440

tcattttttc catttactgc agaggcttca ttttttccat ttactgcaga ggcttcattt     1500

tttccattta ctgcagaact agttaggcgt gtacggtggg aggcctatat aagcagagct     1560

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga     1620

agacaccggg accgatccag cctcgagaga cccaatgcta gccaccatgg ccttaccagt     1680

gaccgccttg ctcctgccgc tggccttgct gctccacgcc gccaggccgt acttcggcaa     1740

gctggaaagc aagctgagcg tgatccggaa cctgaacgac caggtgctgt tcatcgatca     1800

gggcaacaga cccctgttcg aggacatgac cgacagcgac tgcagagaca acgcccctcg     1860

gaccatcttc atcatcagca tgtacaagga cagccagcct agaggcatgg ccgtgaccat     1920

ctctgtgaag tgcgagaaga tcagcaccct gagctgcgag aacaagatca tcagcttcaa     1980

agagatgaac ccgccggaca acatcaagga caccaagagc gacatcatat tcttccagcg     2040

gagcgtgccc ggccacgaca acaagatgca gtttgagagc agcagctacg agggctactt     2100

cctggcctgc gagaaagagc gggacctgtt caagctgatc ctgaagaaag aggacgaact     2160

gggcgaccgc agcatcatgt tcaccgtgca gaacgaggac tgataa                    2206


<210>  1879
<211>  2206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu25E6-8-28-3z1XX-Foxp3-NFAT-IL-18

<400>  1879
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga atctggcgga ggactggtca agcctggagg cagcctgaga      120

ctgagctgcg ccgccagcgg cttcacattc agcagctacg gcatgagctg ggtgcggcag      180

gcccctggca agggcctgga atgggtcagc accatcagca acggcggaag acacaccttc      240

taccccgaca gcgtgaaggg cagattcacc atctcaagag ataacgccaa gaacagcctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactactg cgccagacag      360

accggcacag agggctggtt cgcctactgg ggccagggca ccctggtgac cgtgtccagc      420

ggcggtggcg gaagcggagg cggtggctcc ggtggcggag gcagcgacat cgtgatgacc      480

cagacccctc tgtctctgag cgtgacccct ggccagcctg ccagcatctc ttgtaaaagc      540

agccagagcc tgctggacag cgacggcaag acctacctga actggtacct gcagaagccc      600

ggccaaagcc ctcagctgct gatctacctg gtgtccaagc tggatagcgg tgttcctgat      660

agattcagcg gatctggcag cggcaccgac ttcaccctga agatcagcag agtggaagcc      720

gaggacgtgg gcgtgtacta ctgctggcag ggcacacact tcccccagac attcggccag      780

ggcaccaagg tggaaatcaa gaagcacctg tgtccttctc cactgttccc cggccctagc      840

aagcctttct gggtcctggt ggtggtgggc ggagtgctgg cctgctacag cctgctggtg      900

accgtggcct ttatcatctt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactcctag aagacctggg cctaccagaa agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgttcaat gaactgcaga aagataagat ggcggaggcc     1260

ttcagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggccttttc     1320

cagggtctca gtacagccac caaggacacc ttcgacgccc ttcacatgca ggccctgccc     1380

cctcgctgat aagtttaaac tgccagaaca tttctctggc ctaactggcc ggtaccggct     1440

tcattttttc catttactgc agaggcttca ttttttccat ttactgcaga ggcttcattt     1500

tttccattta ctgcagaact agttaggcgt gtacggtggg aggcctatat aagcagagct     1560

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga     1620

agacaccggg accgatccag cctcgagaga cccaatgcta gccaccatgg ccttaccagt     1680

gaccgccttg ctcctgccgc tggccttgct gctccacgcc gccaggccgt acttcggcaa     1740

gctggaaagc aagctgagcg tgatccggaa cctgaacgac caggtgctgt tcatcgatca     1800

gggcaacaga cccctgttcg aggacatgac cgacagcgac tgcagagaca acgcccctcg     1860

gaccatcttc atcatcagca tgtacaagga cagccagcct agaggcatgg ccgtgaccat     1920

ctctgtgaag tgcgagaaga tcagcaccct gagctgcgag aacaagatca tcagcttcaa     1980

agagatgaac ccgccggaca acatcaagga caccaagagc gacatcatat tcttccagcg     2040

gagcgtgccc ggccacgaca acaagatgca gtttgagagc agcagctacg agggctactt     2100

cctggcctgc gagaaagagc gggacctgtt caagctgatc ctgaagaaag aggacgaact     2160

gggcgaccgc agcatcatgt tcaccgtgca gaacgaggac tgataa                    2206


