﻿                         序列表
<110>  江苏集萃药康生物科技有限公司
<120>  用于构建肝损伤小鼠模型的打靶载体、核酸组合物和构建方法
<130>  OWO20025026
<150>  CN2020107649973
<151>  2020-08-03
<160>  9
<170>  SIPOSequenceListing 1.0
<210>  1
<211>  2419
<212>  DNA
<213>  人工序列
<400>  1
ggtggttctc ctgtcagttt cgagggggta cagcttgggc tgcaggtcga ctctagatcg        60
aattcctgca gcccggggga tcccggggtt gataggaaag gtgatctgtg tgcagaaaga       120
ctcgctctaa tatacttctt taaccaataa ctgtagatca ttaaccatac ttacctcgca       180
tttcattggt tcctacccca ttacaaaatc ataccatctt tgccaaaaag ttgtttgact       240
aaatcccttg cgtatgtttg ccatctggag ctgttcccct ctaaccccac ccccaccccc       300
atgcacaaga ctttgtccat tcattaaagt tatgtaaaac agcaaatttt acataagagc       360
ttaatctctt tgtctcccat ttgagcattt cagtgtgggc cttggcatgg aagcatgcct       420
gcaggtcgat cccaagctgg agaacgagtt caagccaagc tgcaccactg cttttcacac       480
actcttcact ctgcatcagc ttagtatttc ttaagaaatt aaaagatggc aaaacacatc       540
taaactgtat taataaagtg cttctttcat atttaatgtt tttccagata aagaaaacta       600
tgatgaatgc ctgcatgctt atctatgttt catagatcag caagtagaat gtataaaatg       660
gaagtgtcag taattctgct cataattatt gctgcagatt gaattcaccc ctaagcaaat       720
atacctctga acatctgctc acagtctgta tgttctccag acacaatcca aaagacttat       780
tatctgaaag attaatgtca caaagccaga gctttataat ctcttataaa acatagattg       840
tagccaggca gtggtggcac atgcttttaa tcctagcact tgcaaggcag aggcaagcag       900
atctctgagt tcaagaccaa cctggtctac agagcaaggt ccaggacagc caaagctaga       960
cagaaaaaac tgtatctcaa aagaaaatag acaacaaatt acattgttac agctaaaatt      1020
atcttatgtt gaaatttctg tagctcaact ttggaatatt ttcattagag ggtaatattt      1080
gattatgatc acttctaaaa ctttagaatt tattgtttta taatctcttg gtttcagtac      1140
ttacctaaaa ttttccaacc agtcacccag ctaaaactta aaatatttaa gtcctagaat      1200
tccagttagt tttgcaagta actataaatg gtattacagt gagaaatgga gcatctgatg      1260
tctactcaca tgtaaacttt acacatatca aatagatgat tgtctatggt ctttcttctt      1320
ttttagagta tatagagtat atagagatag attcatccat aataagctca ataaacaaat      1380
gtttaaaaat gattgttaga tattattggg tatataagta cctaattatt aaaattgact      1440
tttttataac attgagataa attaaaattc atttattaaa ataatatata tgaatttgaa      1500
ggggtttttt ttgcaaaaca atttcagcaa gcaataccat gacaaaagtg tgtattcaaa      1560
tggaatggga aacgaatgtc agtaacttat ggtccccgtg tactcattcc cagacatgcc      1620
tgattggtag ctgtgacagc tccagcgtac ttaacaccaa gactttaaat aagctgccaa      1680
aaatgtgtaa gactgccatt tcattagttt taatttttat atctataccc tttctacagc      1740
cacatactaa acgtagacaa gttggccttt tcctattgct ttaaaggcag aggactgtat      1800
tgatcagtcc aaacttcttt ctgcatgtac atggaaaact ggccaaggca aacacgtccg      1860
gaatgatggt atttaagaac aaacattccc tggtatcagc aagtacagtg ccctgctgac      1920
agagcaggag acacaaagta ccatctcgtc cctatgttaa gtagtgtcac ctcatgctca      1980
agggatactg agtggatgct gtaacgcagg ttattttcta ggctgtgagg atacaagaaa      2040
atgaaagtaa ttaaagtaga acattgctct gtgctatgct tgcagaatgt gtagtgtagt      2100
ctaggaacag agaggggaag gttctaaatc aaaaaaaatc aagctcatgc ctaaggatgt      2160
gtgggttgcc acctctttag ctacctatgc gatccaaaca actataaaac ttagaattta      2220
ttttctctgg atgaatttgt gcttgtggag caatgttggt agggggcagg gtcagctgga      2280
aaagtggaat gagcaagcag aaaactgaga gaagcagaag cttaggaaga tgggtaattt      2340
ccaaaagttt cacaaaagat caaatcaaag aagtaagctc caccttagaa aaaagtggaa      2400
cgtcatgcta aggaagcta                                                   2419
<210>  2
<211>  747
<212>  DNA
<213>  人工序列
<400>  2
ttacccgggg agcatgtcaa ggtcaaaatc gtcaagagcg tcagcaggca gcatatcaag        60
gtcaaagtcg tcaagggcat cggctgggag catgtctaag tcaaaatcgt caagggcgtc       120
ggtcggcccg ccgctttcgc actttagctg tttctccagg ccacatatga ttagttccag       180
gccgaaaagg aaggcaggtt cggctccctg ccggtcgaac agctcaattg cttgtttcag       240
aagtgggggc atagaatcgg tggtaggtgt ctctctttcc tcttttgcta cttgatgctc       300
ctgttcctcc aatacgcagc ccagtgtaaa gtggcccacg gcggacagag cgtacagtgc       360
gttctccagg gagaagcctt gctgacacag gaacgcgagc tgattttcca gggtttcgta       420
ctgtttctct gttgggcggg tgccgagatg cactttagcc ccgtcgcgat gtgagaggag       480
agcacagcgg tatgacttgg cgttgttccg cagaaagtct tgccatgact cgccttccag       540
ggggcaggag tgggtatgat gcctgtccag catctcgatt ggcagggcat cgagcagggc       600
ccgcttgttc ttcacgtgcc agtacagggt aggctgctca actcccagct tttgagcgag       660
tttccttgtc gtcaggcctt cgataccgac tccattgagt aattccagag cagagtttat       720
gactttgctc ttgtccagtc tagacat                                           747
<210>  3
<211>  635
<212>  DNA
<213>  人工序列
<400>  3
ggctgcagga attcaacagg catctactga gtggacccaa cgcatgagag gacagtgcca        60
agcaagcaac tcaaatgtcc caccggttgg gccatggcag gtagcctatg ctgtgtctgg       120
acgtcctcct gctggtatag ttattttaaa atcagaagga cagggaaggg agcagtggtt       180
cacgcctgta atcccagcaa tttgggaggc caaggtgggt agatcacctg agattaggag       240
ttggagacca gcctggccaa tatggtgaaa ccccgtctct accaaaaaaa caaaaattag       300
ctgagcctgg tcatgcatgc ctggaatccc aacaactcgg gaggctgagg caggagaatc       360
gcttgaaccc aggaggcgga gattgcagtg agccaagatt gtgccactgc actccagctt       420
ggttcccaat agaccccgca ggccctacag gttgtcttcc caacttgccc cttgctccat       480
accacccccc tccaccccat aatattatag aaggacacct agtcagacaa aatgatgcaa       540
cttaatttta ttaggacaag gctggtgggc actggagtgg caacttccag ggccaggaga       600
ggcactgggg aggggtcaca gggatgccac ccatc                                  635
<210>  4
<211>  1352
<212>  DNA
<213>  人工序列
<400>  4
ttggccggtg cgccgccaat cagcggaggc tgccggggcc gcctaaagaa gaggctgtgc        60
tttggggctc cggctcctca gagagcctcg gctaggtagg ggatcgggac tctggcggga       120
gggcggcttg gtgcgtttgc ggggatgggc ggccgcggca ggccctccga gcgtggtgga       180
gccgttctgt gagacagccg ggtacgagtc gtgacgctgg aaggggcaag cgggtggtgg       240
gcaggaatgc ggtccgccct gcagcaaccg gagggggagg gagaagggag cggaaaagtc       300
tccaccggac gcggccatgg ctcggggggg ggggggcagc ggaggagcgc ttccggccga       360
cgtctcgtcg ctgattggct tcttttcctc ccgccgtgtg tgaaaacaca aatggcgtgt       420
tttggttggc gtaaggcgcc tgtcagttaa cggcagccgg agtgcgcagc cgccggcagc       480
ctcgctctgc ccactgggtg gggcgggagg taggtggggt gaggcgagct ggacgtgcgg       540
gcgcggtcgg cctctggcgg ggcgggggag gggagggagg gtcagcgaaa gtagctcgcg       600
cgcgagcggc cgcccaccct ccccttcctc tgggggagtc gttttacccg ccgccggccg       660
ggcctcgtcg tctgattggc tctcggggcc cagaaaactg gcccttgcca ttggctcgtg       720
ttcgtgcaag ttgagtccat ccgccggcca gcgggggcgg cgaggaggcg ctcccaggtt       780
ccggccctcc cctcggcccc gcgccgcaga gtctggccgc gcgcccctgc gcaacgtggc       840
aggaagcgcg cgctgggggc ggggacgggc agtagggctg agcggctgcg gggcgggtgc       900
aagcacgttt ccgacttgag ttgcctcaag aggggcgtgc tgagccagac ctccatcgcg       960
cactccgggg agtggaggga aggagcgagg gctcagttgg gctgttttgg aggcaggaag      1020
cacttgctct cccaaagtcg ctctgagttg ttatcagtaa gggagctgca gtggagtagg      1080
cggggagaag gccgcaccct tctccggagg ggggagggga gtgttgcaat acctttctgg      1140
gagttctctg ctgcctcctg gcttctgagg accgccctgg gcctgggaga atcccttccc      1200
cctcttccct cgtgatctgc aactccagtc tttgcagtct ggtacttcca agctcattag      1260
atgccatcat gctctcactg cctcctcagc ttcaagagga atctggaaaa agcagtccca      1320
ctggtcagga aaggaacact agtgcactta tc                                    1352
<210>  5
<211>  1094
<212>  DNA
<213>  人工序列
<400>  5
tgtgtgggcg ttgtcctgca ggggaattga acaggtgtaa aattggaggg acaagacttc        60
ccacagattt tcggttttgt cgggaagttt tttaataggg gcaaataagg aaaatgggag       120
gataggtagt catctggggt tttatgcagc aaaactacag gttattattg cttgtgatcc       180
gcctcggagt attttccatc gaggtagatt aaagacatgc tcacccgagt tttatactct       240
cctgcttgag atccttacta cagtatgaaa ttacagtgtc gcgagttaga ctatgtaagc       300
agaattttaa tcatttttaa agagcccagt acttcatatc catttctccc gctccttctg       360
cagccttatc aaaaggtatt ttagaacact cattttagcc ccattttcat ttattatact       420
ggcttatcca acccctagac agagcattgg cattttccct ttcctgatct tagaagtctg       480
atgactcatg aaaccagaca gattagttac atacaccaca aatcgaggct gtagctgggg       540
cctcaacact gcagttcttt tataactcct tagtacactt tttgttgatc ctttgccttg       600
atccttaatt ttcagtgtct atcacctctc ccgtcaggtg gtgttccaca tttgggccta       660
ttctcagtcc agggagtttt acaacaatag atgtattgag aatccaacct aaagcttaac       720
tttccactcc catgaatgcc tctctccttt ttctccattt ataaactgag ctattaacca       780
ttaatggttt ccaggtggat gtctcctccc ccaatattac ctgatgtatc ttacatattg       840
ccaggctgat attttaagac attaaaaggt atatttcatt attgagccac atggtattga       900
ttactgctta ctaaaatttt gtcattgtac acatctgtaa aaggtggttc cttttggaat       960
gcaaagttca ggtgtttgtt gtctttcctg acctaaggtc ttgtgagctt gtattttttc      1020
tatttaagca gtgctttctc ttggactggc ttgactcatg gcattctaca cgttattgct      1080
ggtctaaatg tgat                                                        1094
<210>  6
<211>  1715
<212>  DNA
<213>  人工序列
<400>  6
atgaaagtct ggctggcgag cctgttcctc tgcgccttgg tggtgaaaaa ctctgaaggt        60
ggcagtgtac ttggagctcc tgatgaatca aactgtggct gtcagaacgg aggtgtatgc       120
gtgtcctaca agtacttctc cagaattcgc cgatgcagct gcccaaggaa attccagggg       180
gagcactgtg agatagatgc atcaaaaacc tgctatcatg gaaatggtga ctcttaccga       240
ggaaaggcca acactgatac caaaggtcgg ccctgcctgg cctggaatgc gcctgctgtc       300
cttcagaaac cctacaatgc ccacagacct gatgctatta gcctaggcct ggggaaacac       360
aattactgca ggaaccctga caaccagaag cgaccctggt gctatgtgca gattggccta       420
aggcagtttg tccaagaatg catggtgcat gactgctctc ttagcaaaaa gccttcttcg       480
tctgtagacc aacaaggctt ccagtgtggc cagaaggctc taaggccccg ctttaagatt       540
gttgggggag aattcactga ggtggagaac cagccctggt tcgcagccat ctaccagaag       600
aacaagggag gaagtcctcc ctcctttaaa tgtggtggga gtctcatcag tccttgctgg       660
gtggccagtg ccgcacactg cttcattcaa ctcccaaaga aggaaaacta cgttgtctac       720
ctgggtcagt cgaaggagag ctcctataat cctggagaga tgaagtttga ggtggagcag       780
ctcatcttgc acgaatacta cagggaagac agcctggcct accataatga tattgccttg       840
ctgaagatac gtaccagcac gggccaatgt gcacagccat ccaggtccat acagaccatc       900
tgcctgcccc caaggtttac tgatgctccg tttggttcag actgtgagat cactggcttt       960
ggaaaagagt ctgaaagtga ctatctctat ccaaagaacc tgaaaatgtc cgtcgtaaag      1020
cttgtttctc atgaacagtg tatgcagccc cactactatg gctctgaaat taattataaa      1080
atgctgtgtg ctgcggaccc agagtggaaa acagattcct gcaagggcga ttctggagga      1140
ccgcttatct gtaacatcga aggccgccca actctgagtg ggattgtgag ctggggccga      1200
ggatgtgcag agaaaaacaa gcccggtgtc tacacgaggg tctcacactt cctggactgg      1260
attcaatccc acattggaga agagaaaggt ctggccttct gagatctttt tccctctgcc      1320
aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa      1380
tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg aaggacatat      1440
gggagggcaa atcatttaaa acatcagaat gagtatttgg tttagagttt ggcaacatat      1500
gcccatatgc tggctgccat gaacaaaggt tggctataaa gaggtcatca gtatatgaaa      1560
cagccccctg ctgtccattc cttattccat agaaaagcct tgacttgagg ttagattttt      1620
tttatatttt gttttgtgtt atttttttct ttaacatccc taaaattttc cttacatgtt      1680
ttactagcca gatttttcct cctctcctga ctact                                 1715
<210>  7
<211>  433
<212>  PRT
<213>  人工序列
<400>  7
Met Lys Val Trp Leu Ala Ser Leu Phe Leu Cys Ala Leu Val Val Lys 
1               5                   10                  15      
Asn Ser Glu Gly Gly Ser Val Leu Gly Ala Pro Asp Glu Ser Asn Cys 
            20                  25                  30          
Gly Cys Gln Asn Gly Gly Val Cys Val Ser Tyr Lys Tyr Phe Ser Arg 
        35                  40                  45              
Ile Arg Arg Cys Ser Cys Pro Arg Lys Phe Gln Gly Glu His Cys Glu 
    50                  55                  60                  
Ile Asp Ala Ser Lys Thr Cys Tyr His Gly Asn Gly Asp Ser Tyr Arg 
65                  70                  75                  80  
Gly Lys Ala Asn Thr Asp Thr Lys Gly Arg Pro Cys Leu Ala Trp Asn 
                85                  90                  95      
Ala Pro Ala Val Leu Gln Lys Pro Tyr Asn Ala His Arg Pro Asp Ala 
            100                 105                 110         
Ile Ser Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn 
        115                 120                 125             
Gln Lys Arg Pro Trp Cys Tyr Val Gln Ile Gly Leu Arg Gln Phe Val 
    130                 135                 140                 
Gln Glu Cys Met Val His Asp Cys Ser Leu Ser Lys Lys Pro Ser Ser 
145                 150                 155                 160 
Ser Val Asp Gln Gln Gly Phe Gln Cys Gly Gln Lys Ala Leu Arg Pro 
                165                 170                 175     
Arg Phe Lys Ile Val Gly Gly Glu Phe Thr Glu Val Glu Asn Gln Pro 
            180                 185                 190         
Trp Phe Ala Ala Ile Tyr Gln Lys Asn Lys Gly Gly Ser Pro Pro Ser 
        195                 200                 205             
Phe Lys Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ala Ser Ala 
    210                 215                 220                 
Ala His Cys Phe Ile Gln Leu Pro Lys Lys Glu Asn Tyr Val Val Tyr 
225                 230                 235                 240 
Leu Gly Gln Ser Lys Glu Ser Ser Tyr Asn Pro Gly Glu Met Lys Phe 
                245                 250                 255     
Glu Val Glu Gln Leu Ile Leu His Glu Tyr Tyr Arg Glu Asp Ser Leu 
            260                 265                 270         
Ala Tyr His Asn Asp Ile Ala Leu Leu Lys Ile Arg Thr Ser Thr Gly 
        275                 280                 285             
Gln Cys Ala Gln Pro Ser Arg Ser Ile Gln Thr Ile Cys Leu Pro Pro 
    290                 295                 300                 
Arg Phe Thr Asp Ala Pro Phe Gly Ser Asp Cys Glu Ile Thr Gly Phe 
305                 310                 315                 320 
Gly Lys Glu Ser Glu Ser Asp Tyr Leu Tyr Pro Lys Asn Leu Lys Met 
                325                 330                 335     
Ser Val Val Lys Leu Val Ser His Glu Gln Cys Met Gln Pro His Tyr 
            340                 345                 350         
Tyr Gly Ser Glu Ile Asn Tyr Lys Met Leu Cys Ala Ala Asp Pro Glu 
        355                 360                 365             
Trp Lys Thr Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Ile Cys 
    370                 375                 380                 
Asn Ile Glu Gly Arg Pro Thr Leu Ser Gly Ile Val Ser Trp Gly Arg 
385                 390                 395                 400 
Gly Cys Ala Glu Lys Asn Lys Pro Gly Val Tyr Thr Arg Val Ser His 
                405                 410                 415     
Phe Leu Asp Trp Ile Gln Ser His Ile Gly Glu Glu Lys Gly Leu Ala 
            420                 425                 430         
Phe 
    
<210>  8
<211>  379
<212>  DNA
<213>  人工序列
<400>  8
gagtttactc cctatcagtg atagagaacg tatgaagagt ttactcccta tcagtgatag        60
agaacgtatg cagactttac tccctatcag tgatagagaa cgtataagga gtttactccc       120
tatcagtgat agagaacgta tgaccagttt actccctatc agtgatagag aacgtatcta       180
cagtttactc cctatcagtg atagagaacg tatatccagt ttactcccta tcagtgatag       240
agaacgtata agctttaggc gtgtacggtg ggcgcctata aaagcagagc tcgtttagtg       300
aaccgtcaga tcgcctggag caattccaca acacttttgt cttataccaa ctttccgtac       360
cacttcctac cctcgtaaa                                                    379
<210>  9
<211>  20
<212>  DNA
<213>  人工序列
<400>  9
agtcttctgg gcaggcttaa                                                    20

