                         SEQUENCE LISTING



<110>  Sciomics GmbH

 

<120>  Methods for the determination of the predisposition for a severe 

       or critical course of a COVID-19-disease from a mild or moderate 

       course of a COVID-19-disease in a subject



<130>  SC0003P-EP



<160>  152   



<170>  PatentIn version 3.5



<210>  1

<211>  288

<212>  PRT

<213>  Homo sapiens



<400>  1



Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 

1               5                   10                  15      





Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 

            20                  25                  30          





Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 

        35                  40                  45              





Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 

    50                  55                  60                  





Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 

65                  70                  75                  80  





Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 

                85                  90                  95      





Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 

            100                 105                 110         





Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 

        115                 120                 125             





Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 

    130                 135                 140                 





Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 

145                 150                 155                 160 





Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 

                165                 170                 175     





His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 

            180                 185                 190         





Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 

        195                 200                 205             





Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 

    210                 215                 220                 





Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 

225                 230                 235                 240 





Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 

                245                 250                 255     





Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 

            260                 265                 270         





Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 

        275                 280                 285             





<210>  2

<211>  220

<212>  PRT

<213>  Homo sapiens



<400>  2



Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 

1               5                   10                  15      





Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 

            20                  25                  30          





Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 

        35                  40                  45              





Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 

    50                  55                  60                  





Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 

65                  70                  75                  80  





Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 

                85                  90                  95      





Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 

            100                 105                 110         





Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 

        115                 120                 125             





Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 

    130                 135                 140                 





Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 

145                 150                 155                 160 





Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 

                165                 170                 175     





Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 

            180                 185                 190         





Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 

        195                 200                 205             





Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 

    210                 215                 220 





<210>  3

<211>  414

<212>  PRT

<213>  Homo sapiens



<400>  3



Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 

1               5                   10                  15      





Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 

            20                  25                  30          





Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 

        35                  40                  45              





Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 

    50                  55                  60                  





Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 

65                  70                  75                  80  





Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 

                85                  90                  95      





Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 

            100                 105                 110         





Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 

        115                 120                 125             





Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 

    130                 135                 140                 





Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 

145                 150                 155                 160 





Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 

                165                 170                 175     





Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 

            180                 185                 190         





Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 

        195                 200                 205             





Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 

    210                 215                 220                 





His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 

225                 230                 235                 240 





Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 

                245                 250                 255     





Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 

            260                 265                 270         





Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 

        275                 280                 285             





Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 

    290                 295                 300                 





Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 

305                 310                 315                 320 





Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 

                325                 330                 335     





Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 

            340                 345                 350         





Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 

        355                 360                 365             





Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 

    370                 375                 380                 





Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 

385                 390                 395                 400 





Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 

                405                 410                 





<210>  4

<211>  427

<212>  PRT

<213>  Homo sapiens



<400>  4



Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 

1               5                   10                  15      





Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 

            20                  25                  30          





Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 

        35                  40                  45              





Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 

    50                  55                  60                  





Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 

65                  70                  75                  80  





Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 

                85                  90                  95      





Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 

            100                 105                 110         





Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 

        115                 120                 125             





Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 

    130                 135                 140                 





Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 

145                 150                 155                 160 





Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 

                165                 170                 175     





Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 

            180                 185                 190         





Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 

        195                 200                 205             





Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 

    210                 215                 220                 





Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 

225                 230                 235                 240 





Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 

                245                 250                 255     





Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 

            260                 265                 270         





Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 

        275                 280                 285             





Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 

    290                 295                 300                 





Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 

305                 310                 315                 320 





Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 

                325                 330                 335     





Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 

            340                 345                 350         





Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 

        355                 360                 365             





Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 

    370                 375                 380                 





Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 

385                 390                 395                 400 





Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 

                405                 410                 415     





Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 

            420                 425         





<210>  5

<211>  162

<212>  PRT

<213>  Homo sapiens



<400>  5



Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 

1               5                   10                  15      





Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 

            20                  25                  30          





Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 

        35                  40                  45              





Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 

    50                  55                  60                  





Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 

65                  70                  75                  80  





Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 

                85                  90                  95      





Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 

            100                 105                 110         





Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 

        115                 120                 125             





Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 

    130                 135                 140                 





Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 

145                 150                 155                 160 





Thr Ser 

        





<210>  6

<211>  107

<212>  PRT

<213>  Homo sapiens



<400>  6



Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 

1               5                   10                  15      





Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 

            20                  25                  30          





Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 

        35                  40                  45              





Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 

    50                  55                  60                  





Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 

65                  70                  75                  80  





Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 

                85                  90                  95      





Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 

            100                 105         





<210>  7

<211>  380

<212>  PRT

<213>  Homo sapiens



<400>  7



Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 

1               5                   10                  15      





Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 

            20                  25                  30          





Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 

        35                  40                  45              





Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 

    50                  55                  60                  





Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 

65                  70                  75                  80  





Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 

                85                  90                  95      





Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 

            100                 105                 110         





Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 

        115                 120                 125             





Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 

    130                 135                 140                 





Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 

145                 150                 155                 160 





Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 

                165                 170                 175     





Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 

            180                 185                 190         





Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 

        195                 200                 205             





Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 

    210                 215                 220                 





Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 

225                 230                 235                 240 





Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 

                245                 250                 255     





Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 

            260                 265                 270         





Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 

        275                 280                 285             





Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 

    290                 295                 300                 





Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 

305                 310                 315                 320 





Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 

                325                 330                 335     





Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 

            340                 345                 350         





Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 

        355                 360                 365             





Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 

    370                 375                 380 





<210>  8

<211>  554

<212>  PRT

<213>  Homo sapiens



<400>  8



Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 

1               5                   10                  15      





Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 

            20                  25                  30          





Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 

        35                  40                  45              





Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 

    50                  55                  60                  





Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 

65                  70                  75                  80  





Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 

                85                  90                  95      





Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 

            100                 105                 110         





Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 

        115                 120                 125             





Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 

    130                 135                 140                 





Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 

145                 150                 155                 160 





Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 

                165                 170                 175     





Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 

            180                 185                 190         





Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 

        195                 200                 205             





Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 

    210                 215                 220                 





Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 

225                 230                 235                 240 





Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 

                245                 250                 255     





Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 

            260                 265                 270         





Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 

        275                 280                 285             





Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 

    290                 295                 300                 





Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 

305                 310                 315                 320 





Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 

                325                 330                 335     





Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 

            340                 345                 350         





Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 

        355                 360                 365             





Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 

    370                 375                 380                 





Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 

385                 390                 395                 400 





Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 

                405                 410                 415     





Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 

            420                 425                 430         





Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 

        435                 440                 445             





Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 

    450                 455                 460                 





Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 

465                 470                 475                 480 





His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 

                485                 490                 495     





Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 

            500                 505                 510         





Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 

        515                 520                 525             





Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 

    530                 535                 540                 





Gln Asp Asp Arg Gln Val Glu Leu Pro Val 

545                 550                 





<210>  9

<211>  1367

<212>  PRT

<213>  Homo sapiens



<400>  9



Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 

1               5                   10                  15      





Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 

            20                  25                  30          





Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 

        35                  40                  45              





Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 

    50                  55                  60                  





Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 

65                  70                  75                  80  





Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 

                85                  90                  95      





Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 

            100                 105                 110         





Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 

        115                 120                 125             





Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 

    130                 135                 140                 





Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 

145                 150                 155                 160 





Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 

                165                 170                 175     





Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 

            180                 185                 190         





Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 

        195                 200                 205             





Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 

    210                 215                 220                 





Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 

225                 230                 235                 240 





Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 

                245                 250                 255     





Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 

            260                 265                 270         





Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 

        275                 280                 285             





Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 

    290                 295                 300                 





Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 

305                 310                 315                 320 





Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 

                325                 330                 335     





Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 

            340                 345                 350         





Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 

        355                 360                 365             





Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 

    370                 375                 380                 





Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 

385                 390                 395                 400 





Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 

                405                 410                 415     





Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 

            420                 425                 430         





Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 

        435                 440                 445             





Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 

    450                 455                 460                 





Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 

465                 470                 475                 480 





Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 

                485                 490                 495     





Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 

            500                 505                 510         





Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 

        515                 520                 525             





Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 

    530                 535                 540                 





Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 

545                 550                 555                 560 





Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 

                565                 570                 575     





Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 

            580                 585                 590         





His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 

        595                 600                 605             





Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 

    610                 615                 620                 





Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 

625                 630                 635                 640 





Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 

                645                 650                 655     





Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 

            660                 665                 670         





Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 

        675                 680                 685             





Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 

    690                 695                 700                 





Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 

705                 710                 715                 720 





Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 

                725                 730                 735     





Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 

            740                 745                 750         





Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 

        755                 760                 765             





Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 

    770                 775                 780                 





Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 

785                 790                 795                 800 





Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 

                805                 810                 815     





Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 

            820                 825                 830         





Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 

        835                 840                 845             





Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 

    850                 855                 860                 





Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 

865                 870                 875                 880 





Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 

                885                 890                 895     





Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 

            900                 905                 910         





Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 

        915                 920                 925             





Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 

    930                 935                 940                 





Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 

945                 950                 955                 960 





Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 

                965                 970                 975     





Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 

            980                 985                 990         





Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 

        995                 1000                 1005             





Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 

    1010                 1015                 1020             





Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 

    1025                 1030                 1035             





Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 

    1040                 1045                 1050             





Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 

    1055                 1060                 1065             





Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 

    1070                 1075                 1080             





Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 

    1085                 1090                 1095             





Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 

    1100                 1105                 1110             





Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 

    1115                 1120                 1125             





Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 

    1130                 1135                 1140             





Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 

    1145                 1150                 1155             





Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 

    1160                 1165                 1170             





Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 

    1175                 1180                 1185             





Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 

    1190                 1195                 1200             





Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 

    1205                 1210                 1215             





Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 

    1220                 1225                 1230             





Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 

    1235                 1240                 1245             





Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 

    1250                 1255                 1260             





Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 

    1265                 1270                 1275             





Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 

    1280                 1285                 1290             





Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 

    1295                 1300                 1305             





Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 

    1310                 1315                 1320             





Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 

    1325                 1330                 1335             





Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 

    1340                 1345                 1350             





Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 

    1355                 1360                 1365         





<210>  10

<211>  628

<212>  PRT

<213>  Homo sapiens



<400>  10



Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 

1               5                   10                  15      





Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 

            20                  25                  30          





Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 

        35                  40                  45              





Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 

    50                  55                  60                  





Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 

65                  70                  75                  80  





Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 

                85                  90                  95      





Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 

            100                 105                 110         





Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 

        115                 120                 125             





Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 

    130                 135                 140                 





Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 

145                 150                 155                 160 





Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 

                165                 170                 175     





Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 

            180                 185                 190         





Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 

        195                 200                 205             





Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 

    210                 215                 220                 





Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 

225                 230                 235                 240 





Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 

                245                 250                 255     





His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 

            260                 265                 270         





Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 

        275                 280                 285             





Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 

    290                 295                 300                 





Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 

305                 310                 315                 320 





Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 

                325                 330                 335     





Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 

            340                 345                 350         





Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 

        355                 360                 365             





Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 

    370                 375                 380                 





Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 

385                 390                 395                 400 





Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 

                405                 410                 415     





Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 

            420                 425                 430         





Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 

        435                 440                 445             





Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 

    450                 455                 460                 





Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 

465                 470                 475                 480 





Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 

                485                 490                 495     





Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 

            500                 505                 510         





Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 

        515                 520                 525             





Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 

    530                 535                 540                 





Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 

545                 550                 555                 560 





Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 

                565                 570                 575     





Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 

            580                 585                 590         





Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 

        595                 600                 605             





Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 

    610                 615                 620                 





Gly Asp Glu Cys 

625             





<210>  11

<211>  583

<212>  PRT

<213>  Homo sapiens



<400>  11



Met Glu Ser Lys Gly Ala Ser Ser Cys Arg Leu Leu Phe Cys Leu Leu 

1               5                   10                  15      





Ile Ser Ala Thr Val Phe Arg Pro Gly Leu Gly Trp Tyr Thr Val Asn 

            20                  25                  30          





Ser Ala Tyr Gly Asp Thr Ile Ile Ile Pro Cys Arg Leu Asp Val Pro 

        35                  40                  45              





Gln Asn Leu Met Phe Gly Lys Trp Lys Tyr Glu Lys Pro Asp Gly Ser 

    50                  55                  60                  





Pro Val Phe Ile Ala Phe Arg Ser Ser Thr Lys Lys Ser Val Gln Tyr 

65                  70                  75                  80  





Asp Asp Val Pro Glu Tyr Lys Asp Arg Leu Asn Leu Ser Glu Asn Tyr 

                85                  90                  95      





Thr Leu Ser Ile Ser Asn Ala Arg Ile Ser Asp Glu Lys Arg Phe Val 

            100                 105                 110         





Cys Met Leu Val Thr Glu Asp Asn Val Phe Glu Ala Pro Thr Ile Val 

        115                 120                 125             





Lys Val Phe Lys Gln Pro Ser Lys Pro Glu Ile Val Ser Lys Ala Leu 

    130                 135                 140                 





Phe Leu Glu Thr Glu Gln Leu Lys Lys Leu Gly Asp Cys Ile Ser Glu 

145                 150                 155                 160 





Asp Ser Tyr Pro Asp Gly Asn Ile Thr Trp Tyr Arg Asn Gly Lys Val 

                165                 170                 175     





Leu His Pro Leu Glu Gly Ala Val Val Ile Ile Phe Lys Lys Glu Met 

            180                 185                 190         





Asp Pro Val Thr Gln Leu Tyr Thr Met Thr Ser Thr Leu Glu Tyr Lys 

        195                 200                 205             





Thr Thr Lys Ala Asp Ile Gln Met Pro Phe Thr Cys Ser Val Thr Tyr 

    210                 215                 220                 





Tyr Gly Pro Ser Gly Gln Lys Thr Ile His Ser Glu Gln Ala Val Phe 

225                 230                 235                 240 





Asp Ile Tyr Tyr Pro Thr Glu Gln Val Thr Ile Gln Val Leu Pro Pro 

                245                 250                 255     





Lys Asn Ala Ile Lys Glu Gly Asp Asn Ile Thr Leu Lys Cys Leu Gly 

            260                 265                 270         





Asn Gly Asn Pro Pro Pro Glu Glu Phe Leu Phe Tyr Leu Pro Gly Gln 

        275                 280                 285             





Pro Glu Gly Ile Arg Ser Ser Asn Thr Tyr Thr Leu Thr Asp Val Arg 

    290                 295                 300                 





Arg Asn Ala Thr Gly Asp Tyr Lys Cys Ser Leu Ile Asp Lys Lys Ser 

305                 310                 315                 320 





Met Ile Ala Ser Thr Ala Ile Thr Val His Tyr Leu Asp Leu Ser Leu 

                325                 330                 335     





Asn Pro Ser Gly Glu Val Thr Arg Gln Ile Gly Asp Ala Leu Pro Val 

            340                 345                 350         





Ser Cys Thr Ile Ser Ala Ser Arg Asn Ala Thr Val Val Trp Met Lys 

        355                 360                 365             





Asp Asn Ile Arg Leu Arg Ser Ser Pro Ser Phe Ser Ser Leu His Tyr 

    370                 375                 380                 





Gln Asp Ala Gly Asn Tyr Val Cys Glu Thr Ala Leu Gln Glu Val Glu 

385                 390                 395                 400 





Gly Leu Lys Lys Arg Glu Ser Leu Thr Leu Ile Val Glu Gly Lys Pro 

                405                 410                 415     





Gln Ile Lys Met Thr Lys Lys Thr Asp Pro Ser Gly Leu Ser Lys Thr 

            420                 425                 430         





Ile Ile Cys His Val Glu Gly Phe Pro Lys Pro Ala Ile Gln Trp Thr 

        435                 440                 445             





Ile Thr Gly Ser Gly Ser Val Ile Asn Gln Thr Glu Glu Ser Pro Tyr 

    450                 455                 460                 





Ile Asn Gly Arg Tyr Tyr Ser Lys Ile Ile Ile Ser Pro Glu Glu Asn 

465                 470                 475                 480 





Val Thr Leu Thr Cys Thr Ala Glu Asn Gln Leu Glu Arg Thr Val Asn 

                485                 490                 495     





Ser Leu Asn Val Ser Ala Ile Ser Ile Pro Glu His Asp Glu Ala Asp 

            500                 505                 510         





Glu Ile Ser Asp Glu Asn Arg Glu Lys Val Asn Asp Gln Ala Lys Leu 

        515                 520                 525             





Ile Val Gly Ile Val Val Gly Leu Leu Leu Ala Ala Leu Val Ala Gly 

    530                 535                 540                 





Val Val Tyr Trp Leu Tyr Met Lys Lys Ser Lys Thr Ala Ser Lys His 

545                 550                 555                 560 





Val Asn Lys Asp Leu Gly Asn Met Glu Glu Asn Lys Lys Leu Glu Glu 

                565                 570                 575     





Asn Asn His Lys Thr Glu Ala 

            580             





<210>  12

<211>  278

<212>  PRT

<213>  Homo sapiens



<400>  12



Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 

1               5                   10                  15      





Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 

            20                  25                  30          





Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 

        35                  40                  45              





Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 

    50                  55                  60                  





Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 

65                  70                  75                  80  





Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 

                85                  90                  95      





Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 

            100                 105                 110         





Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 

        115                 120                 125             





Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 

    130                 135                 140                 





Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 

145                 150                 155                 160 





Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 

                165                 170                 175     





Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 

            180                 185                 190         





Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 

        195                 200                 205             





Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 

    210                 215                 220                 





Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 

225                 230                 235                 240 





Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 

                245                 250                 255     





Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln 

            260                 265                 270         





Gly Val Gln Lys Met Thr 

        275             





<210>  13

<211>  1306

<212>  PRT

<213>  Homo sapiens



<400>  13



Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 

1               5                   10                  15      





Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 

            20                  25                  30          





Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 

        35                  40                  45              





Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 

    50                  55                  60                  





Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 

65                  70                  75                  80  





Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 

                85                  90                  95      





Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 

            100                 105                 110         





Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 

        115                 120                 125             





Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 

    130                 135                 140                 





Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 

145                 150                 155                 160 





Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 

                165                 170                 175     





Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 

            180                 185                 190         





Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 

        195                 200                 205             





Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 

    210                 215                 220                 





Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 

225                 230                 235                 240 





Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 

                245                 250                 255     





Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 

            260                 265                 270         





Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 

        275                 280                 285             





Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 

    290                 295                 300                 





Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 

305                 310                 315                 320 





Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 

                325                 330                 335     





Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 

            340                 345                 350         





Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 

        355                 360                 365             





Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 

    370                 375                 380                 





Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 

385                 390                 395                 400 





Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 

                405                 410                 415     





Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 

            420                 425                 430         





Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 

        435                 440                 445             





Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 

    450                 455                 460                 





Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 

465                 470                 475                 480 





Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 

                485                 490                 495     





Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 

            500                 505                 510         





Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 

        515                 520                 525             





Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 

    530                 535                 540                 





Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 

545                 550                 555                 560 





Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 

                565                 570                 575     





Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 

            580                 585                 590         





Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 

        595                 600                 605             





Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 

    610                 615                 620                 





Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 

625                 630                 635                 640 





Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 

                645                 650                 655     





Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 

            660                 665                 670         





Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 

        675                 680                 685             





Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 

    690                 695                 700                 





Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 

705                 710                 715                 720 





Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 

                725                 730                 735     





Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 

            740                 745                 750         





Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 

        755                 760                 765             





Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 

    770                 775                 780                 





Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 

785                 790                 795                 800 





Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 

                805                 810                 815     





Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 

            820                 825                 830         





Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 

        835                 840                 845             





Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 

    850                 855                 860                 





Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 

865                 870                 875                 880 





Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 

                885                 890                 895     





Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 

            900                 905                 910         





Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 

        915                 920                 925             





Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 

    930                 935                 940                 





Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 

945                 950                 955                 960 





His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 

                965                 970                 975     





Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 

            980                 985                 990         





Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 

        995                 1000                 1005             





Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 

    1010                 1015                 1020             





Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 

    1025                 1030                 1035             





Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 

    1040                 1045                 1050             





Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 

    1055                 1060                 1065             





Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 

    1070                 1075                 1080             





Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 

    1085                 1090                 1095             





Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 

    1100                 1105                 1110             





Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 

    1115                 1120                 1125             





Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 

    1130                 1135                 1140             





Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 

    1145                 1150                 1155             





His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 

    1160                 1165                 1170             





Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 

    1175                 1180                 1185             





Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 

    1190                 1195                 1200             





Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 

    1205                 1210                 1215             





Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 

    1220                 1225                 1230             





Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 

    1235                 1240                 1245             





Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 

    1250                 1255                 1260             





Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 

    1265                 1270                 1275             





Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 

    1280                 1285                 1290             





Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 

    1295                 1300                 1305     





<210>  14

<211>  427

<212>  PRT

<213>  Homo sapiens



<400>  14



Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 

1               5                   10                  15      





Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 

            20                  25                  30          





Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 

        35                  40                  45              





Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 

    50                  55                  60                  





Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 

65                  70                  75                  80  





Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 

                85                  90                  95      





Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 

            100                 105                 110         





Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 

        115                 120                 125             





Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 

    130                 135                 140                 





Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 

145                 150                 155                 160 





Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 

                165                 170                 175     





Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 

            180                 185                 190         





Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 

        195                 200                 205             





Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 

    210                 215                 220                 





Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 

225                 230                 235                 240 





Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 

                245                 250                 255     





Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 

            260                 265                 270         





Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 

        275                 280                 285             





Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 

    290                 295                 300                 





Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 

305                 310                 315                 320 





Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 

                325                 330                 335     





Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 

            340                 345                 350         





Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 

        355                 360                 365             





Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 

    370                 375                 380                 





Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 

385                 390                 395                 400 





Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 

                405                 410                 415     





Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 

            420                 425         





<210>  15

<211>  372

<212>  PRT

<213>  Homo sapiens



<400>  15



Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 

1               5                   10                  15      





Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 

            20                  25                  30          





Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 

        35                  40                  45              





Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 

    50                  55                  60                  





Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 

65                  70                  75                  80  





Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 

                85                  90                  95      





Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 

            100                 105                 110         





Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 

        115                 120                 125             





His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 

    130                 135                 140                 





Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 

145                 150                 155                 160 





Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 

                165                 170                 175     





Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 

            180                 185                 190         





Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 

        195                 200                 205             





Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 

    210                 215                 220                 





Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 

225                 230                 235                 240 





Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 

                245                 250                 255     





Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 

            260                 265                 270         





Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 

        275                 280                 285             





Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 

    290                 295                 300                 





Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 

305                 310                 315                 320 





Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 

                325                 330                 335     





Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 

            340                 345                 350         





Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 

        355                 360                 365             





Leu Thr Thr Phe 

    370         





<210>  16

<211>  98

<212>  PRT

<213>  Homo sapiens



<400>  16



Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 

1               5                   10                  15      





Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 

            20                  25                  30          





Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 

        35                  40                  45              





Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 

    50                  55                  60                  





Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 

65                  70                  75                  80  





Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 

                85                  90                  95      





Ser Ser 

        





<210>  17

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  17



Met Ala Thr Leu Leu Leu Leu Leu Gly Val Leu Val Val Ser Pro Asp 

1               5                   10                  15      





Ala Leu Gly Ser Thr Thr Ala Val Gln Thr Pro Thr Ser Gly Glu Pro 

            20                  25                  30          





Leu Val Ser Thr Ser Glu Pro Leu Ser Ser Lys Met Tyr Thr Thr Ser 

        35                  40                  45              





Ile Thr Ser Asp Pro Lys Ala Asp Ser Thr Gly Asp Gln Thr Ser Ala 

    50                  55                  60                  





Leu Pro Pro Ser Thr Ser Ile Asn Glu Gly Ser Pro Leu Trp Thr Ser 

65                  70                  75                  80  





Ile Gly Ala Ser Thr Gly Ser Pro Leu Pro Glu Pro Thr Thr Tyr Gln 

                85                  90                  95      





Glu Val Ser Ile Lys Met Ser Ser Val Pro Gln Glu Thr Pro His Ala 

            100                 105                 110         





Thr Ser His Pro Ala Val Pro Ile Thr Ala Asn Ser Leu Gly Ser His 

        115                 120                 125             





Thr Val Thr Gly Gly Thr Ile Thr Thr Asn Ser Pro Glu Thr Ser Ser 

    130                 135                 140                 





Arg Thr Ser Gly Ala Pro Val Thr Thr Ala Ala Ser Ser Leu Glu Thr 

145                 150                 155                 160 





Ser Arg Gly Thr Ser Gly Pro Pro Leu Thr Met Ala Thr Val Ser Leu 

                165                 170                 175     





Glu Thr Ser Lys Gly Thr Ser Gly Pro Pro Val Thr Met Ala Thr Asp 

            180                 185                 190         





Ser Leu Glu Thr Ser Thr Gly Thr Thr Gly Pro Pro Val Thr Met Thr 

        195                 200                 205             





Thr Gly Ser Leu Glu Pro Ser Ser Gly Ala Ser Gly Pro Gln Val Ser 

    210                 215                 220                 





Ser Val Lys Leu Ser Thr Met Met Ser Pro Thr Thr Ser Thr Asn Ala 

225                 230                 235                 240 





Ser Thr Val Pro Phe Arg Asn Pro Asp Glu Asn Ser Arg Gly Met Leu 

                245                 250                 255     





Pro Val Ala Val Leu Val Ala Leu Leu Ala Val Ile Val Leu Val Ala 

            260                 265                 270         





Leu Leu Leu Leu Trp Arg Arg Arg Gln Lys Arg Arg Thr Gly Ala Leu 

        275                 280                 285             





Val Leu Ser Arg Gly Gly Lys Arg Asn Gly Val Val Asp Ala Trp Ala 

    290                 295                 300                 





Gly Pro Ala Gln Val Pro Glu Glu Gly Ala Val Thr Val Thr Val Gly 

305                 310                 315                 320 





Gly Ser Gly Gly Asp Lys Gly Ser Gly Phe Pro Asp Gly Glu Gly Ser 

                325                 330                 335     





Ser Arg Arg Pro Thr Leu Thr Thr Phe Phe Gly Arg Arg Lys Ser Arg 

            340                 345                 350         





Gln Gly Ser Leu Ala Met Glu Glu Leu Lys Ser Gly Ser Gly Pro Ser 

        355                 360                 365             





Leu Lys Gly Glu Glu Glu Pro Leu Val Ala Ser Glu Asp Gly Ala Val 

    370                 375                 380                 





Asp Ala Pro Ala Pro Asp Glu Pro Glu Gly Gly Asp Gly Ala Ala Pro 

385                 390                 395                 400 





<210>  18

<211>  532

<212>  PRT

<213>  Homo sapiens



<400>  18



Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 

1               5                   10                  15      





Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 

            20                  25                  30          





Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 

        35                  40                  45              





Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 

    50                  55                  60                  





Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 

65                  70                  75                  80  





Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 

                85                  90                  95      





Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 

            100                 105                 110         





Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 

        115                 120                 125             





Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 

    130                 135                 140                 





Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 

145                 150                 155                 160 





Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 

                165                 170                 175     





Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 

            180                 185                 190         





Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 

        195                 200                 205             





Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 

    210                 215                 220                 





Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 

225                 230                 235                 240 





Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 

                245                 250                 255     





Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 

            260                 265                 270         





Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 

        275                 280                 285             





Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 

    290                 295                 300                 





Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 

305                 310                 315                 320 





Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 

                325                 330                 335     





Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 

            340                 345                 350         





Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 

        355                 360                 365             





Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 

    370                 375                 380                 





Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 

385                 390                 395                 400 





Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 

                405                 410                 415     





Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 

            420                 425                 430         





Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 

        435                 440                 445             





Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 

    450                 455                 460                 





Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 

465                 470                 475                 480 





Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 

                485                 490                 495     





Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 

            500                 505                 510         





Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 

        515                 520                 525             





Ala Thr Pro Pro 

    530         





<210>  19

<211>  183

<212>  PRT

<213>  Homo sapiens



<400>  19



Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 

1               5                   10                  15      





Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 

            20                  25                  30          





Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 

        35                  40                  45              





Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 

    50                  55                  60                  





Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 

65                  70                  75                  80  





Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 

                85                  90                  95      





Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 

            100                 105                 110         





Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 

        115                 120                 125             





Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 

    130                 135                 140                 





Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 

145                 150                 155                 160 





Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 

                165                 170                 175     





Pro Gly Glu Phe Cys Val Leu 

            180             





<210>  20

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  20



Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 

1               5                   10                  15      





Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 

            20                  25                  30          





Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Gly Glu Thr 

        35                  40                  45              





Gly Gln Leu Val His Arg Phe Thr Val Pro Ala Pro Val Val Ile Ile 

    50                  55                  60                  





Leu Ile Ile Leu Cys Val Met Ala Gly Ile Ile Gly Thr Ile Leu Leu 

65                  70                  75                  80  





Ile Ser Tyr Ser Ile Arg Arg Leu Ile Lys Ala 

                85                  90      





<210>  21

<211>  153

<212>  PRT

<213>  Homo sapiens



<400>  21



Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 

1               5                   10                  15      





Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 

            20                  25                  30          





Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 

        35                  40                  45              





Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 

    50                  55                  60                  





Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 

65                  70                  75                  80  





Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 

                85                  90                  95      





Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 

            100                 105                 110         





Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 

        115                 120                 125             





Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 

    130                 135                 140                 





Cys Gln Ser Ile Ile Ser Thr Leu Thr 

145                 150             





<210>  22

<211>  290

<212>  PRT

<213>  Homo sapiens



<400>  22



Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 

1               5                   10                  15      





Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 

            20                  25                  30          





Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 

        35                  40                  45              





Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 

    50                  55                  60                  





Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 

65                  70                  75                  80  





Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 

                85                  90                  95      





Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 

            100                 105                 110         





Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 

        115                 120                 125             





Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 

    130                 135                 140                 





Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 

145                 150                 155                 160 





Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 

                165                 170                 175     





Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 

            180                 185                 190         





Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 

        195                 200                 205             





Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 

    210                 215                 220                 





Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 

225                 230                 235                 240 





Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 

                245                 250                 255     





Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 

            260                 265                 270         





Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 

        275                 280                 285             





Glu Thr 

    290 





<210>  23

<211>  112

<212>  PRT

<213>  Homo sapiens



<400>  23



Met Lys Gly Pro Pro Thr Phe Cys Ser Leu Leu Leu Leu Ser Leu Leu 

1               5                   10                  15      





Leu Ser Pro Asp Pro Thr Ala Ala Phe Leu Leu Pro Pro Ser Thr Ala 

            20                  25                  30          





Cys Cys Thr Gln Leu Tyr Arg Lys Pro Leu Ser Asp Lys Leu Leu Arg 

        35                  40                  45              





Lys Val Ile Gln Val Glu Leu Gln Glu Ala Asp Gly Asp Cys His Leu 

    50                  55                  60                  





Gln Ala Phe Val Leu His Leu Ala Gln Arg Ser Ile Cys Ile His Pro 

65                  70                  75                  80  





Gln Asn Pro Ser Leu Ser Gln Trp Phe Glu His Gln Glu Arg Lys Leu 

                85                  90                  95      





His Gly Thr Leu Pro Lys Leu Asn Phe Gly Met Leu Arg Lys Met Gly 

            100                 105                 110         





<210>  24

<211>  152

<212>  PRT

<213>  Homo sapiens



<400>  24



Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 

1               5                   10                  15      





Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 

            20                  25                  30          





Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 

        35                  40                  45              





Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 

    50                  55                  60                  





Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 

65                  70                  75                  80  





Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 

                85                  90                  95      





Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 

            100                 105                 110         





Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 

        115                 120                 125             





Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 

    130                 135                 140                 





Thr Thr Leu Ser Leu Ala Ile Phe 

145                 150         





<210>  25

<211>  215

<212>  PRT

<213>  Homo sapiens



<400>  25



Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 

1               5                   10                  15      





Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 

            20                  25                  30          





Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 

        35                  40                  45              





Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 

    50                  55                  60                  





Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 

65                  70                  75                  80  





Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 

                85                  90                  95      





Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 

            100                 105                 110         





Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 

        115                 120                 125             





Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 

    130                 135                 140                 





Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 

145                 150                 155                 160 





Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 

                165                 170                 175     





Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 

            180                 185                 190         





Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 

        195                 200                 205             





Glu Glu Asp Asp Asp Asp Glu 

    210                 215 





<210>  26

<211>  609

<212>  PRT

<213>  Homo sapiens



<400>  26



Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 

1               5                   10                  15      





Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 

            20                  25                  30          





His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 

        35                  40                  45              





Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 

    50                  55                  60                  





Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 

65                  70                  75                  80  





Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 

                85                  90                  95      





Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 

            100                 105                 110         





Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 

        115                 120                 125             





His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 

    130                 135                 140                 





Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 

145                 150                 155                 160 





Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 

                165                 170                 175     





Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 

            180                 185                 190         





Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 

        195                 200                 205             





Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 

    210                 215                 220                 





Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 

225                 230                 235                 240 





Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 

                245                 250                 255     





Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 

            260                 265                 270         





Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 

        275                 280                 285             





Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 

    290                 295                 300                 





Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 

305                 310                 315                 320 





Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 

                325                 330                 335     





Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 

            340                 345                 350         





Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 

        355                 360                 365             





Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 

    370                 375                 380                 





Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 

385                 390                 395                 400 





Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 

                405                 410                 415     





Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 

            420                 425                 430         





Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 

        435                 440                 445             





Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 

    450                 455                 460                 





Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 

465                 470                 475                 480 





Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 

                485                 490                 495     





Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 

            500                 505                 510         





Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 

        515                 520                 525             





Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 

    530                 535                 540                 





Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 

545                 550                 555                 560 





Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 

                565                 570                 575     





Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 

            580                 585                 590         





Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 

        595                 600                 605             





Leu 

    





<210>  27

<211>  335

<212>  PRT

<213>  Homo sapiens



<400>  27



Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 

1               5                   10                  15      





Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 

            20                  25                  30          





Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 

        35                  40                  45              





Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 

    50                  55                  60                  





Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 

65                  70                  75                  80  





Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 

                85                  90                  95      





Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 

            100                 105                 110         





Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 

        115                 120                 125             





Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 

    130                 135                 140                 





Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 

145                 150                 155                 160 





Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 

                165                 170                 175     





Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 

            180                 185                 190         





Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 

        195                 200                 205             





Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 

    210                 215                 220                 





Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 

225                 230                 235                 240 





Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 

                245                 250                 255     





Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 

            260                 265                 270         





Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 

        275                 280                 285             





Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 

    290                 295                 300                 





Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 

305                 310                 315                 320 





Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 

                325                 330                 335 





<210>  28

<211>  323

<212>  PRT

<213>  Homo sapiens



<400>  28



Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 

305                 310                 315                 320 





Asn Asp Glu 

            





<210>  29

<211>  233

<212>  PRT

<213>  Homo sapiens



<400>  29



Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 

1               5                   10                  15      





Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 

            20                  25                  30          





Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 

        35                  40                  45              





Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 

    50                  55                  60                  





Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 

65                  70                  75                  80  





Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 

                85                  90                  95      





Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 

            100                 105                 110         





Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 

        115                 120                 125             





Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 

    130                 135                 140                 





Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 

145                 150                 155                 160 





Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 

                165                 170                 175     





Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 

            180                 185                 190         





Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 

        195                 200                 205             





Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 

    210                 215                 220                 





Gln Val Tyr Phe Gly Ile Ile Ala Leu 

225                 230             





<210>  30

<211>  904

<212>  PRT

<213>  Homo sapiens



<400>  30



Met Arg Gln Thr Leu Pro Cys Ile Tyr Phe Trp Gly Gly Leu Leu Pro 

1               5                   10                  15      





Phe Gly Met Leu Cys Ala Ser Ser Thr Thr Lys Cys Thr Val Ser His 

            20                  25                  30          





Glu Val Ala Asp Cys Ser His Leu Lys Leu Thr Gln Val Pro Asp Asp 

        35                  40                  45              





Leu Pro Thr Asn Ile Thr Val Leu Asn Leu Thr His Asn Gln Leu Arg 

    50                  55                  60                  





Arg Leu Pro Ala Ala Asn Phe Thr Arg Tyr Ser Gln Leu Thr Ser Leu 

65                  70                  75                  80  





Asp Val Gly Phe Asn Thr Ile Ser Lys Leu Glu Pro Glu Leu Cys Gln 

                85                  90                  95      





Lys Leu Pro Met Leu Lys Val Leu Asn Leu Gln His Asn Glu Leu Ser 

            100                 105                 110         





Gln Leu Ser Asp Lys Thr Phe Ala Phe Cys Thr Asn Leu Thr Glu Leu 

        115                 120                 125             





His Leu Met Ser Asn Ser Ile Gln Lys Ile Lys Asn Asn Pro Phe Val 

    130                 135                 140                 





Lys Gln Lys Asn Leu Ile Thr Leu Asp Leu Ser His Asn Gly Leu Ser 

145                 150                 155                 160 





Ser Thr Lys Leu Gly Thr Gln Val Gln Leu Glu Asn Leu Gln Glu Leu 

                165                 170                 175     





Leu Leu Ser Asn Asn Lys Ile Gln Ala Leu Lys Ser Glu Glu Leu Asp 

            180                 185                 190         





Ile Phe Ala Asn Ser Ser Leu Lys Lys Leu Glu Leu Ser Ser Asn Gln 

        195                 200                 205             





Ile Lys Glu Phe Ser Pro Gly Cys Phe His Ala Ile Gly Arg Leu Phe 

    210                 215                 220                 





Gly Leu Phe Leu Asn Asn Val Gln Leu Gly Pro Ser Leu Thr Glu Lys 

225                 230                 235                 240 





Leu Cys Leu Glu Leu Ala Asn Thr Ser Ile Arg Asn Leu Ser Leu Ser 

                245                 250                 255     





Asn Ser Gln Leu Ser Thr Thr Ser Asn Thr Thr Phe Leu Gly Leu Lys 

            260                 265                 270         





Trp Thr Asn Leu Thr Met Leu Asp Leu Ser Tyr Asn Asn Leu Asn Val 

        275                 280                 285             





Val Gly Asn Asp Ser Phe Ala Trp Leu Pro Gln Leu Glu Tyr Phe Phe 

    290                 295                 300                 





Leu Glu Tyr Asn Asn Ile Gln His Leu Phe Ser His Ser Leu His Gly 

305                 310                 315                 320 





Leu Phe Asn Val Arg Tyr Leu Asn Leu Lys Arg Ser Phe Thr Lys Gln 

                325                 330                 335     





Ser Ile Ser Leu Ala Ser Leu Pro Lys Ile Asp Asp Phe Ser Phe Gln 

            340                 345                 350         





Trp Leu Lys Cys Leu Glu His Leu Asn Met Glu Asp Asn Asp Ile Pro 

        355                 360                 365             





Gly Ile Lys Ser Asn Met Phe Thr Gly Leu Ile Asn Leu Lys Tyr Leu 

    370                 375                 380                 





Ser Leu Ser Asn Ser Phe Thr Ser Leu Arg Thr Leu Thr Asn Glu Thr 

385                 390                 395                 400 





Phe Val Ser Leu Ala His Ser Pro Leu His Ile Leu Asn Leu Thr Lys 

                405                 410                 415     





Asn Lys Ile Ser Lys Ile Glu Ser Asp Ala Phe Ser Trp Leu Gly His 

            420                 425                 430         





Leu Glu Val Leu Asp Leu Gly Leu Asn Glu Ile Gly Gln Glu Leu Thr 

        435                 440                 445             





Gly Gln Glu Trp Arg Gly Leu Glu Asn Ile Phe Glu Ile Tyr Leu Ser 

    450                 455                 460                 





Tyr Asn Lys Tyr Leu Gln Leu Thr Arg Asn Ser Phe Ala Leu Val Pro 

465                 470                 475                 480 





Ser Leu Gln Arg Leu Met Leu Arg Arg Val Ala Leu Lys Asn Val Asp 

                485                 490                 495     





Ser Ser Pro Ser Pro Phe Gln Pro Leu Arg Asn Leu Thr Ile Leu Asp 

            500                 505                 510         





Leu Ser Asn Asn Asn Ile Ala Asn Ile Asn Asp Asp Met Leu Glu Gly 

        515                 520                 525             





Leu Glu Lys Leu Glu Ile Leu Asp Leu Gln His Asn Asn Leu Ala Arg 

    530                 535                 540                 





Leu Trp Lys His Ala Asn Pro Gly Gly Pro Ile Tyr Phe Leu Lys Gly 

545                 550                 555                 560 





Leu Ser His Leu His Ile Leu Asn Leu Glu Ser Asn Gly Phe Asp Glu 

                565                 570                 575     





Ile Pro Val Glu Val Phe Lys Asp Leu Phe Glu Leu Lys Ile Ile Asp 

            580                 585                 590         





Leu Gly Leu Asn Asn Leu Asn Thr Leu Pro Ala Ser Val Phe Asn Asn 

        595                 600                 605             





Gln Val Ser Leu Lys Ser Leu Asn Leu Gln Lys Asn Leu Ile Thr Ser 

    610                 615                 620                 





Val Glu Lys Lys Val Phe Gly Pro Ala Phe Arg Asn Leu Thr Glu Leu 

625                 630                 635                 640 





Asp Met Arg Phe Asn Pro Phe Asp Cys Thr Cys Glu Ser Ile Ala Trp 

                645                 650                 655     





Phe Val Asn Trp Ile Asn Glu Thr His Thr Asn Ile Pro Glu Leu Ser 

            660                 665                 670         





Ser His Tyr Leu Cys Asn Thr Pro Pro His Tyr His Gly Phe Pro Val 

        675                 680                 685             





Arg Leu Phe Asp Thr Ser Ser Cys Lys Asp Ser Ala Pro Phe Glu Leu 

    690                 695                 700                 





Phe Phe Met Ile Asn Thr Ser Ile Leu Leu Ile Phe Ile Phe Ile Val 

705                 710                 715                 720 





Leu Leu Ile His Phe Glu Gly Trp Arg Ile Ser Phe Tyr Trp Asn Val 

                725                 730                 735     





Ser Val His Arg Val Leu Gly Phe Lys Glu Ile Asp Arg Gln Thr Glu 

            740                 745                 750         





Gln Phe Glu Tyr Ala Ala Tyr Ile Ile His Ala Tyr Lys Asp Lys Asp 

        755                 760                 765             





Trp Val Trp Glu His Phe Ser Ser Met Glu Lys Glu Asp Gln Ser Leu 

    770                 775                 780                 





Lys Phe Cys Leu Glu Glu Arg Asp Phe Glu Ala Gly Val Phe Glu Leu 

785                 790                 795                 800 





Glu Ala Ile Val Asn Ser Ile Lys Arg Ser Arg Lys Ile Ile Phe Val 

                805                 810                 815     





Ile Thr His His Leu Leu Lys Asp Pro Leu Cys Lys Arg Phe Lys Val 

            820                 825                 830         





His His Ala Val Gln Gln Ala Ile Glu Gln Asn Leu Asp Ser Ile Ile 

        835                 840                 845             





Leu Val Phe Leu Glu Glu Ile Pro Asp Tyr Lys Leu Asn His Ala Leu 

    850                 855                 860                 





Cys Leu Arg Arg Gly Met Phe Lys Ser His Cys Ile Leu Asn Trp Pro 

865                 870                 875                 880 





Val Gln Lys Glu Arg Ile Gly Ala Phe Arg His Lys Leu Gln Val Ala 

                885                 890                 895     





Leu Gly Ser Lys Asn Ser Val His 

            900                 





<210>  31

<211>  450

<212>  PRT

<213>  Homo sapiens



<400>  31



Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 

1               5                   10                  15      





Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 

            20                  25                  30          





Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 

        35                  40                  45              





Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 

    50                  55                  60                  





Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 

65                  70                  75                  80  





Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 

                85                  90                  95      





Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 

            100                 105                 110         





Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 

        115                 120                 125             





Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 

    130                 135                 140                 





Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 

145                 150                 155                 160 





Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 

                165                 170                 175     





Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 

            180                 185                 190         





Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 

        195                 200                 205             





Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 

    210                 215                 220                 





Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 

225                 230                 235                 240 





Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 

                245                 250                 255     





Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 

            260                 265                 270         





Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 

        275                 280                 285             





Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 

    290                 295                 300                 





Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 

305                 310                 315                 320 





Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 

                325                 330                 335     





Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 

            340                 345                 350         





Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 

        355                 360                 365             





Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 

    370                 375                 380                 





Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 

385                 390                 395                 400 





Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 

                405                 410                 415     





Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 

            420                 425                 430         





Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 

        435                 440                 445             





Pro Lys 

    450 





<210>  32

<211>  93

<212>  PRT

<213>  Homo sapiens



<400>  32



Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 

1               5                   10                  15      





His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 

            20                  25                  30          





Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 

        35                  40                  45              





Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 

    50                  55                  60                  





Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 

65                  70                  75                  80  





Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 

                85                  90              





<210>  33

<211>  114

<212>  PRT

<213>  Homo sapiens



<400>  33



Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 

1               5                   10                  15      





Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 

            20                  25                  30          





Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 

        35                  40                  45              





Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 

    50                  55                  60                  





Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 

65                  70                  75                  80  





Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 

                85                  90                  95      





Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 

            100                 105                 110         





Thr Pro 

        





<210>  34

<211>  317

<212>  PRT

<213>  Homo sapiens



<400>  34



Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 

1               5                   10                  15      





Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 

            20                  25                  30          





Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 

        35                  40                  45              





Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 

    50                  55                  60                  





Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 

65                  70                  75                  80  





Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 

                85                  90                  95      





Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 

            100                 105                 110         





Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 

        115                 120                 125             





Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 

    130                 135                 140                 





Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 

145                 150                 155                 160 





Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 

                165                 170                 175     





Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 

            180                 185                 190         





Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 

        195                 200                 205             





Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 

    210                 215                 220                 





His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 

225                 230                 235                 240 





Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 

                245                 250                 255     





Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 

            260                 265                 270         





Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 

        275                 280                 285             





Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 

    290                 295                 300                 





Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 

305                 310                 315         





<210>  35

<211>  760

<212>  PRT

<213>  Homo sapiens



<400>  35



Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 

1               5                   10                  15      





Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 

            20                  25                  30          





Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 

        35                  40                  45              





Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 

    50                  55                  60                  





Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 

65                  70                  75                  80  





Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 

                85                  90                  95      





Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 

            100                 105                 110         





Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 

        115                 120                 125             





Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 

    130                 135                 140                 





Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 

145                 150                 155                 160 





Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 

                165                 170                 175     





Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 

            180                 185                 190         





Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 

        195                 200                 205             





Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 

    210                 215                 220                 





Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 

225                 230                 235                 240 





Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 

                245                 250                 255     





Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 

            260                 265                 270         





Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 

        275                 280                 285             





Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 

    290                 295                 300                 





Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 

305                 310                 315                 320 





Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 

                325                 330                 335     





Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 

            340                 345                 350         





Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 

        355                 360                 365             





Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 

    370                 375                 380                 





Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 

385                 390                 395                 400 





His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 

                405                 410                 415     





Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 

            420                 425                 430         





Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 

        435                 440                 445             





Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 

    450                 455                 460                 





Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 

465                 470                 475                 480 





Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 

                485                 490                 495     





Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 

            500                 505                 510         





Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 

        515                 520                 525             





Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 

    530                 535                 540                 





Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 

545                 550                 555                 560 





Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 

                565                 570                 575     





Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 

            580                 585                 590         





Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 

        595                 600                 605             





Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 

    610                 615                 620                 





Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 

625                 630                 635                 640 





Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 

                645                 650                 655     





Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 

            660                 665                 670         





Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 

        675                 680                 685             





Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 

    690                 695                 700                 





Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 

705                 710                 715                 720 





Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 

                725                 730                 735     





Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 

            740                 745                 750         





Val Trp Asp Ile Asp Asn Glu Phe 

        755                 760 





<210>  36

<211>  595

<212>  PRT

<213>  Homo sapiens



<400>  36



Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 

1               5                   10                  15      





Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 

            20                  25                  30          





Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 

        35                  40                  45              





Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 

    50                  55                  60                  





Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 

65                  70                  75                  80  





Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 

                85                  90                  95      





Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 

            100                 105                 110         





Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 

        115                 120                 125             





Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 

    130                 135                 140                 





Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 

145                 150                 155                 160 





Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 

                165                 170                 175     





Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 

            180                 185                 190         





Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 

        195                 200                 205             





Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 

    210                 215                 220                 





Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 

225                 230                 235                 240 





Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 

                245                 250                 255     





Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 

            260                 265                 270         





Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 

        275                 280                 285             





Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 

    290                 295                 300                 





Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 

305                 310                 315                 320 





Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 

                325                 330                 335     





Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 

            340                 345                 350         





Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 

        355                 360                 365             





Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 

    370                 375                 380                 





Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 

385                 390                 395                 400 





Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 

                405                 410                 415     





Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 

            420                 425                 430         





Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 

        435                 440                 445             





Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 

    450                 455                 460                 





Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 

465                 470                 475                 480 





Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 

                485                 490                 495     





Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 

            500                 505                 510         





Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 

        515                 520                 525             





Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 

    530                 535                 540                 





Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 

545                 550                 555                 560 





Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 

                565                 570                 575     





Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 

            580                 585                 590         





Ser Gly Lys 

        595 





<210>  37

<211>  526

<212>  PRT

<213>  Homo sapiens



<400>  37



Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 

1               5                   10                  15      





Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 

            20                  25                  30          





Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 

        35                  40                  45              





Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 

    50                  55                  60                  





Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 

65                  70                  75                  80  





Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 

                85                  90                  95      





Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 

            100                 105                 110         





Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 

        115                 120                 125             





Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 

    130                 135                 140                 





Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 

145                 150                 155                 160 





Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 

                165                 170                 175     





Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 

            180                 185                 190         





Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 

        195                 200                 205             





Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 

    210                 215                 220                 





Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 

225                 230                 235                 240 





Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 

                245                 250                 255     





Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 

            260                 265                 270         





Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 

        275                 280                 285             





Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 

    290                 295                 300                 





Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 

305                 310                 315                 320 





Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 

                325                 330                 335     





Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 

            340                 345                 350         





Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 

        355                 360                 365             





Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 

    370                 375                 380                 





Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 

385                 390                 395                 400 





Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 

                405                 410                 415     





Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 

            420                 425                 430         





Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 

        435                 440                 445             





Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 

    450                 455                 460                 





Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 

465                 470                 475                 480 





Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 

                485                 490                 495     





Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 

            500                 505                 510         





Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 

        515                 520                 525     





<210>  38

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  38



Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 

1               5                   10                  15      





Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 

            20                  25                  30          





Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 

        35                  40                  45              





Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 

    50                  55                  60                  





Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 

65                  70                  75                  80  





Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 

                85                  90                  95      





Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 

            100                 105                 110         





Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 

        115                 120                 125             





Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 

    130                 135                 140                 





Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 

145                 150                 155                 160 





Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 

                165                 170                 175     





Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 

            180                 185                 190         





Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 

        195                 200                 205             





Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 

    210                 215                 220                 





Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 

225                 230                 235                 240 





Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 

                245                 250         





<210>  39

<211>  702

<212>  PRT

<213>  Homo sapiens



<400>  39



Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 

1               5                   10                  15      





Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 

            20                  25                  30          





Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 

        35                  40                  45              





Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 

    50                  55                  60                  





Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 

65                  70                  75                  80  





Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 

                85                  90                  95      





Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 

            100                 105                 110         





Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 

        115                 120                 125             





Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 

    130                 135                 140                 





Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 

145                 150                 155                 160 





Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 

                165                 170                 175     





Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 

            180                 185                 190         





Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 

        195                 200                 205             





Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 

    210                 215                 220                 





Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 

225                 230                 235                 240 





Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 

                245                 250                 255     





Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 

            260                 265                 270         





Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 

        275                 280                 285             





Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 

    290                 295                 300                 





Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 

305                 310                 315                 320 





Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 

                325                 330                 335     





Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 

            340                 345                 350         





Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 

        355                 360                 365             





Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 

    370                 375                 380                 





Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 

385                 390                 395                 400 





Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 

                405                 410                 415     





Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 

            420                 425                 430         





Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 

        435                 440                 445             





Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 

    450                 455                 460                 





Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 

465                 470                 475                 480 





Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 

                485                 490                 495     





Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 

            500                 505                 510         





Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 

        515                 520                 525             





Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 

    530                 535                 540                 





Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 

545                 550                 555                 560 





Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 

                565                 570                 575     





Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 

            580                 585                 590         





Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 

        595                 600                 605             





Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 

    610                 615                 620                 





Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 

625                 630                 635                 640 





Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 

                645                 650                 655     





Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 

            660                 665                 670         





Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 

        675                 680                 685             





Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 

    690                 695                 700         





<210>  40

<211>  344

<212>  PRT

<213>  Homo sapiens



<400>  40



Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 

1               5                   10                  15      





Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 

            20                  25                  30          





Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 

        35                  40                  45              





Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 

    50                  55                  60                  





Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 

65                  70                  75                  80  





Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 

                85                  90                  95      





Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 

            100                 105                 110         





Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 

        115                 120                 125             





Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 

    130                 135                 140                 





Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 

145                 150                 155                 160 





Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 

                165                 170                 175     





Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 

            180                 185                 190         





Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 

        195                 200                 205             





Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 

    210                 215                 220                 





Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro 

225                 230                 235                 240 





Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 

                245                 250                 255     





Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 

            260                 265                 270         





Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 

        275                 280                 285             





Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 

    290                 295                 300                 





Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 

305                 310                 315                 320 





Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 

                325                 330                 335     





Val Leu Ala Arg Val Ala Leu Ile 

            340                 





<210>  41

<211>  349

<212>  PRT

<213>  Homo sapiens



<400>  41



Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 

1               5                   10                  15      





Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 

            20                  25                  30          





Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 

        35                  40                  45              





Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 

    50                  55                  60                  





Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 

65                  70                  75                  80  





Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 

                85                  90                  95      





Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 

            100                 105                 110         





Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 

        115                 120                 125             





Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 

    130                 135                 140                 





Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 

145                 150                 155                 160 





Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 

                165                 170                 175     





Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 

            180                 185                 190         





Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 

        195                 200                 205             





Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 

    210                 215                 220                 





Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 

225                 230                 235                 240 





Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 

                245                 250                 255     





Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 

            260                 265                 270         





Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 

        275                 280                 285             





Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 

    290                 295                 300                 





Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 

305                 310                 315                 320 





Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 

                325                 330                 335     





Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 

            340                 345                 





<210>  42

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  42



Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 

1               5                   10                  15      





Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 

            20                  25                  30          





Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 

        35                  40                  45              





Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 

    50                  55                  60                  





Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 

65                  70                  75                  80  





Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 

                85                  90                  95      





Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 

            100                 105                 110         





Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 

        115                 120                 125             





Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 

    130                 135                 140                 





Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 

145                 150                 155                 160 





Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 

                165                 170                 175     





Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 

            180                 185                 190         





Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 

        195                 200                 205             





Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 

    210                 215                 220                 





Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 

225                 230                 235                 240 





Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 

                245                 250         





<210>  43

<211>  362

<212>  PRT

<213>  Homo sapiens



<400>  43



Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 

1               5                   10                  15      





Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 

            20                  25                  30          





Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 

        35                  40                  45              





Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 

    50                  55                  60                  





Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 

65                  70                  75                  80  





Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 

                85                  90                  95      





Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 

            100                 105                 110         





Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 

        115                 120                 125             





Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 

    130                 135                 140                 





Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 

145                 150                 155                 160 





Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 

                165                 170                 175     





Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 

            180                 185                 190         





Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 

        195                 200                 205             





Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 

    210                 215                 220                 





Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 

225                 230                 235                 240 





Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 

                245                 250                 255     





Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 

            260                 265                 270         





Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 

        275                 280                 285             





Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 

    290                 295                 300                 





Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 

305                 310                 315                 320 





Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 

                325                 330                 335     





Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 

            340                 345                 350         





Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 

        355                 360         





<210>  44

<211>  236

<212>  PRT

<213>  Homo sapiens



<400>  44



Met Gly Val Glu Gly Cys Thr Lys Cys Ile Lys Tyr Leu Leu Phe Val 

1               5                   10                  15      





Phe Asn Phe Val Phe Trp Leu Ala Gly Gly Val Ile Leu Gly Val Ala 

            20                  25                  30          





Leu Trp Leu Arg His Asp Pro Gln Thr Thr Asn Leu Leu Tyr Leu Glu 

        35                  40                  45              





Leu Gly Asp Lys Pro Ala Pro Asn Thr Phe Tyr Val Gly Ile Tyr Ile 

    50                  55                  60                  





Leu Ile Ala Val Gly Ala Val Met Met Phe Val Gly Phe Leu Gly Cys 

65                  70                  75                  80  





Tyr Gly Ala Ile Gln Glu Ser Gln Cys Leu Leu Gly Thr Phe Phe Thr 

                85                  90                  95      





Cys Leu Val Ile Leu Phe Ala Cys Glu Val Ala Ala Gly Ile Trp Gly 

            100                 105                 110         





Phe Val Asn Lys Asp Gln Ile Ala Lys Asp Val Lys Gln Phe Tyr Asp 

        115                 120                 125             





Gln Ala Leu Gln Gln Ala Val Val Asp Asp Asp Ala Asn Asn Ala Lys 

    130                 135                 140                 





Ala Val Val Lys Thr Phe His Glu Thr Leu Asp Cys Cys Gly Ser Ser 

145                 150                 155                 160 





Thr Leu Thr Ala Leu Thr Thr Ser Val Leu Lys Asn Asn Leu Cys Pro 

                165                 170                 175     





Ser Gly Ser Asn Ile Ile Ser Asn Leu Phe Lys Glu Asp Cys His Gln 

            180                 185                 190         





Lys Ile Asp Asp Leu Phe Ser Gly Lys Leu Tyr Leu Ile Gly Ile Ala 

        195                 200                 205             





Ala Ile Val Val Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met 

    210                 215                 220                 





Val Leu Cys Cys Gly Ile Arg Asn Ser Ser Val Tyr 

225                 230                 235     





<210>  45

<211>  232

<212>  PRT

<213>  Homo sapiens



<400>  45



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 

    130                 135                 140                 





Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 

145                 150                 155                 160 





Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 

                165                 170                 175     





Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys 

            180                 185                 190         





His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn 

        195                 200                 205             





Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr 

    210                 215                 220                 





Cys Arg Cys Asp Lys Pro Arg Arg 

225                 230         





<210>  46

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  46



Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Thr 

1               5                   10                  15      





Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 

            20                  25                  30          





Thr Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 

        35                  40                  45              





Glu Ser Tyr Thr Arg Ile Thr Asn Ile Gln Cys Pro Lys Glu Ala Val 

    50                  55                  60                  





Ile Phe Lys Thr Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 

65                  70                  75                  80  





Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 

                85                  90                  95      





Leu Lys Pro 

            





<210>  47

<211>  164

<212>  PRT

<213>  Homo sapiens



<400>  47



Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 

1               5                   10                  15      





Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 

            20                  25                  30          





Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 

        35                  40                  45              





Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 

    50                  55                  60                  





Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 

65                  70                  75                  80  





Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 

                85                  90                  95      





Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 

            100                 105                 110         





Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 

        115                 120                 125             





Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 

    130                 135                 140                 





Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 

145                 150                 155                 160 





Gln Ala Thr Thr 

                





<210>  48

<211>  430

<212>  PRT

<213>  Homo sapiens



<400>  48



Met Ser Phe Thr Thr Arg Ser Thr Phe Ser Thr Asn Tyr Arg Ser Leu 

1               5                   10                  15      





Gly Ser Val Gln Ala Pro Ser Tyr Gly Ala Arg Pro Val Ser Ser Ala 

            20                  25                  30          





Ala Ser Val Tyr Ala Gly Ala Gly Gly Ser Gly Ser Arg Ile Ser Val 

        35                  40                  45              





Ser Arg Ser Thr Ser Phe Arg Gly Gly Met Gly Ser Gly Gly Leu Ala 

    50                  55                  60                  





Thr Gly Ile Ala Gly Gly Leu Ala Gly Met Gly Gly Ile Gln Asn Glu 

65                  70                  75                  80  





Lys Glu Thr Met Gln Ser Leu Asn Asp Arg Leu Ala Ser Tyr Leu Asp 

                85                  90                  95      





Arg Val Arg Ser Leu Glu Thr Glu Asn Arg Arg Leu Glu Ser Lys Ile 

            100                 105                 110         





Arg Glu His Leu Glu Lys Lys Gly Pro Gln Val Arg Asp Trp Ser His 

        115                 120                 125             





Tyr Phe Lys Ile Ile Glu Asp Leu Arg Ala Gln Ile Phe Ala Asn Thr 

    130                 135                 140                 





Val Asp Asn Ala Arg Ile Val Leu Gln Ile Asp Asn Ala Arg Leu Ala 

145                 150                 155                 160 





Ala Asp Asp Phe Arg Val Lys Tyr Glu Thr Glu Leu Ala Met Arg Gln 

                165                 170                 175     





Ser Val Glu Asn Asp Ile His Gly Leu Arg Lys Val Ile Asp Asp Thr 

            180                 185                 190         





Asn Ile Thr Arg Leu Gln Leu Glu Thr Glu Ile Glu Ala Leu Lys Glu 

        195                 200                 205             





Glu Leu Leu Phe Met Lys Lys Asn His Glu Glu Glu Val Lys Gly Leu 

    210                 215                 220                 





Gln Ala Gln Ile Ala Ser Ser Gly Leu Thr Val Glu Val Asp Ala Pro 

225                 230                 235                 240 





Lys Ser Gln Asp Leu Ala Lys Ile Met Ala Asp Ile Arg Ala Gln Tyr 

                245                 250                 255     





Asp Glu Leu Ala Arg Lys Asn Arg Glu Glu Leu Asp Lys Tyr Trp Ser 

            260                 265                 270         





Gln Gln Ile Glu Glu Ser Thr Thr Val Val Thr Thr Gln Ser Ala Glu 

        275                 280                 285             





Val Gly Ala Ala Glu Thr Thr Leu Thr Glu Leu Arg Arg Thr Val Gln 

    290                 295                 300                 





Ser Leu Glu Ile Asp Leu Asp Ser Met Arg Asn Leu Lys Ala Ser Leu 

305                 310                 315                 320 





Glu Asn Ser Leu Arg Glu Val Glu Ala Arg Tyr Ala Leu Gln Met Glu 

                325                 330                 335     





Gln Leu Asn Gly Ile Leu Leu His Leu Glu Ser Glu Leu Ala Gln Thr 

            340                 345                 350         





Arg Ala Glu Gly Gln Arg Gln Ala Gln Glu Tyr Glu Ala Leu Leu Asn 

        355                 360                 365             





Ile Lys Val Lys Leu Glu Ala Glu Ile Ala Thr Tyr Arg Arg Leu Leu 

    370                 375                 380                 





Glu Asp Gly Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp Ser Ser Asn 

385                 390                 395                 400 





Ser Met Gln Thr Ile Gln Lys Thr Thr Thr Arg Arg Ile Val Asp Gly 

                405                 410                 415     





Lys Val Val Ser Glu Thr Asn Asp Thr Lys Val Leu Arg His 

            420                 425                 430 





<210>  49

<211>  328

<212>  PRT

<213>  Homo sapiens



<400>  49



Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 

1               5                   10                  15      





Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 

            20                  25                  30          





Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 

        35                  40                  45              





Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 

    50                  55                  60                  





Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 

65                  70                  75                  80  





Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 

                85                  90                  95      





Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 

            100                 105                 110         





Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 

        115                 120                 125             





Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 

    130                 135                 140                 





Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 

145                 150                 155                 160 





Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 

                165                 170                 175     





Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 

            180                 185                 190         





Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 

        195                 200                 205             





Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 

    210                 215                 220                 





Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 

225                 230                 235                 240 





Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 

                245                 250                 255     





Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 

            260                 265                 270         





Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 

        275                 280                 285             





Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 

    290                 295                 300                 





Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 

305                 310                 315                 320 





Glu Trp Ala Ser Val Pro Cys Ser 

                325             





<210>  50

<211>  1255

<212>  PRT

<213>  Homo sapiens



<400>  50



Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 

1               5                   10                  15      





Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 

            20                  25                  30          





Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 

        35                  40                  45              





Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 

    50                  55                  60                  





Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 

65                  70                  75                  80  





Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 

                85                  90                  95      





Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 

            100                 105                 110         





Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 

        115                 120                 125             





Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 

    130                 135                 140                 





Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 

145                 150                 155                 160 





Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 

                165                 170                 175     





Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 

            180                 185                 190         





His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 

        195                 200                 205             





Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 

    210                 215                 220                 





Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 

225                 230                 235                 240 





Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 

                245                 250                 255     





His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 

            260                 265                 270         





Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 

        275                 280                 285             





Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 

    290                 295                 300                 





Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 

305                 310                 315                 320 





Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 

                325                 330                 335     





Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 

            340                 345                 350         





Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 

        355                 360                 365             





Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 

    370                 375                 380                 





Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 

385                 390                 395                 400 





Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 

                405                 410                 415     





Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 

            420                 425                 430         





Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 

        435                 440                 445             





Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 

    450                 455                 460                 





Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 

465                 470                 475                 480 





Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 

                485                 490                 495     





Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 

            500                 505                 510         





Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 

        515                 520                 525             





Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 

    530                 535                 540                 





Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 

545                 550                 555                 560 





Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 

                565                 570                 575     





Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 

            580                 585                 590         





Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 

        595                 600                 605             





Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 

    610                 615                 620                 





Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 

625                 630                 635                 640 





Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 

                645                 650                 655     





Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 

            660                 665                 670         





Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 

        675                 680                 685             





Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 

    690                 695                 700                 





Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 

705                 710                 715                 720 





Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 

                725                 730                 735     





Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 

            740                 745                 750         





Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 

        755                 760                 765             





Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 

    770                 775                 780                 





Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 

785                 790                 795                 800 





Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 

                805                 810                 815     





Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 

            820                 825                 830         





Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 

        835                 840                 845             





Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 

    850                 855                 860                 





Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 

865                 870                 875                 880 





Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 

                885                 890                 895     





Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 

            900                 905                 910         





Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 

        915                 920                 925             





Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 

    930                 935                 940                 





Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 

945                 950                 955                 960 





Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 

                965                 970                 975     





Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 

            980                 985                 990         





Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 

        995                 1000                 1005             





Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 

    1010                 1015                 1020             





Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 

    1025                 1030                 1035             





Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 

    1040                 1045                 1050             





Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 

    1055                 1060                 1065             





Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 

    1070                 1075                 1080             





Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 

    1085                 1090                 1095             





Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 

    1100                 1105                 1110             





Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 

    1115                 1120                 1125             





Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 

    1130                 1135                 1140             





Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 

    1145                 1150                 1155             





Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 

    1160                 1165                 1170             





Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 

    1175                 1180                 1185             





Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 

    1190                 1195                 1200             





Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 

    1205                 1210                 1215             





Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 

    1220                 1225                 1230             





Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 

    1235                 1240                 1245             





Leu Gly  Leu Asp Val Pro Val  

    1250                 1255 





<210>  51

<211>  766

<212>  PRT

<213>  Homo sapiens



<400>  51



Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 

1               5                   10                  15      





Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 

            20                  25                  30          





Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 

        35                  40                  45              





Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 

    50                  55                  60                  





Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 

65                  70                  75                  80  





Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 

                85                  90                  95      





Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 

            100                 105                 110         





Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 

        115                 120                 125             





Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 

    130                 135                 140                 





Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 

145                 150                 155                 160 





Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 

                165                 170                 175     





Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 

            180                 185                 190         





Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 

        195                 200                 205             





Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 

    210                 215                 220                 





Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 

225                 230                 235                 240 





Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 

                245                 250                 255     





Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 

            260                 265                 270         





Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 

        275                 280                 285             





Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 

    290                 295                 300                 





Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 

305                 310                 315                 320 





Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 

                325                 330                 335     





Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 

            340                 345                 350         





Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 

        355                 360                 365             





Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 

    370                 375                 380                 





Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 

385                 390                 395                 400 





Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 

                405                 410                 415     





Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 

            420                 425                 430         





Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 

        435                 440                 445             





Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 

    450                 455                 460                 





Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 

465                 470                 475                 480 





Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 

                485                 490                 495     





Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 

            500                 505                 510         





Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 

        515                 520                 525             





Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 

    530                 535                 540                 





Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 

545                 550                 555                 560 





Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 

                565                 570                 575     





Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 

            580                 585                 590         





Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 

        595                 600                 605             





Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 

    610                 615                 620                 





Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 

625                 630                 635                 640 





Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 

                645                 650                 655     





Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 

            660                 665                 670         





Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 

        675                 680                 685             





Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 

    690                 695                 700                 





Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 

705                 710                 715                 720 





Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 

                725                 730                 735     





Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 

            740                 745                 750         





Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 

        755                 760                 765     





<210>  52

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  52



Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 

1               5                   10                  15      





His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 

            20                  25                  30          





Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 

        35                  40                  45              





Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 

    50                  55                  60                  





Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 

65                  70                  75                  80  





Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 

                85                  90                  95      





Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 

            100                 105                 110         





Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 

        115                 120                 125             





Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 

    130                 135                 140                 





Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 

145                 150                 155                 160 





Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 

                165                 170                 175     





Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 

            180                 185                 190         





Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 

        195                 200                 205             





Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 

    210                 215                 220                 





Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 

225                 230                 235 





<210>  53

<211>  271

<212>  PRT

<213>  Homo sapiens



<400>  53



Met Ala Lys Val Pro Asp Met Phe Glu Asp Leu Lys Asn Cys Tyr Ser 

1               5                   10                  15      





Glu Asn Glu Glu Asp Ser Ser Ser Ile Asp His Leu Ser Leu Asn Gln 

            20                  25                  30          





Lys Ser Phe Tyr His Val Ser Tyr Gly Pro Leu His Glu Gly Cys Met 

        35                  40                  45              





Asp Gln Ser Val Ser Leu Ser Ile Ser Glu Thr Ser Lys Thr Ser Lys 

    50                  55                  60                  





Leu Thr Phe Lys Glu Ser Met Val Val Val Ala Thr Asn Gly Lys Val 

65                  70                  75                  80  





Leu Lys Lys Arg Arg Leu Ser Leu Ser Gln Ser Ile Thr Asp Asp Asp 

                85                  90                  95      





Leu Glu Ala Ile Ala Asn Asp Ser Glu Glu Glu Ile Ile Lys Pro Arg 

            100                 105                 110         





Ser Ala Pro Phe Ser Phe Leu Ser Asn Val Lys Tyr Asn Phe Met Arg 

        115                 120                 125             





Ile Ile Lys Tyr Glu Phe Ile Leu Asn Asp Ala Leu Asn Gln Ser Ile 

    130                 135                 140                 





Ile Arg Ala Asn Asp Gln Tyr Leu Thr Ala Ala Ala Leu His Asn Leu 

145                 150                 155                 160 





Asp Glu Ala Val Lys Phe Asp Met Gly Ala Tyr Lys Ser Ser Lys Asp 

                165                 170                 175     





Asp Ala Lys Ile Thr Val Ile Leu Arg Ile Ser Lys Thr Gln Leu Tyr 

            180                 185                 190         





Val Thr Ala Gln Asp Glu Asp Gln Pro Val Leu Leu Lys Glu Met Pro 

        195                 200                 205             





Glu Ile Pro Lys Thr Ile Thr Gly Ser Glu Thr Asn Leu Leu Phe Phe 

    210                 215                 220                 





Trp Glu Thr His Gly Thr Lys Asn Tyr Phe Thr Ser Val Ala His Pro 

225                 230                 235                 240 





Asn Leu Phe Ile Ala Thr Lys Gln Asp Tyr Trp Val Cys Leu Ala Gly 

                245                 250                 255     





Gly Pro Pro Ser Ile Thr Asp Phe Gln Ile Leu Glu Asn Gln Ala 

            260                 265                 270     





<210>  54

<211>  301

<212>  PRT

<213>  Homo sapiens



<400>  54



Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 

1               5                   10                  15      





Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 

            20                  25                  30          





Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 

        35                  40                  45              





Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 

    50                  55                  60                  





Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 

65                  70                  75                  80  





Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 

                85                  90                  95      





Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 

            100                 105                 110         





Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 

        115                 120                 125             





Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 

    130                 135                 140                 





Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 

145                 150                 155                 160 





Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 

                165                 170                 175     





Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 

            180                 185                 190         





Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 

        195                 200                 205             





Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 

    210                 215                 220                 





Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 

225                 230                 235                 240 





Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 

                245                 250                 255     





Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 

            260                 265                 270         





Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 

        275                 280                 285             





Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 

    290                 295                 300     





<210>  55

<211>  106

<212>  PRT

<213>  Homo sapiens



<400>  55



Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 

1               5                   10                  15      





Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 

            20                  25                  30          





Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 

        35                  40                  45              





Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 

    50                  55                  60                  





Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 

65                  70                  75                  80  





Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 

                85                  90                  95      





Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 

            100                 105     





<210>  56

<211>  281

<212>  PRT

<213>  Homo sapiens



<400>  56



Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 

1               5                   10                  15      





Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 

            20                  25                  30          





Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 

        35                  40                  45              





Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 

    50                  55                  60                  





Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 

65                  70                  75                  80  





Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 

                85                  90                  95      





Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 

            100                 105                 110         





Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 

        115                 120                 125             





Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 

    130                 135                 140                 





Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 

145                 150                 155                 160 





Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 

                165                 170                 175     





Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 

            180                 185                 190         





Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 

        195                 200                 205             





His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 

    210                 215                 220                 





Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 

225                 230                 235                 240 





Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 

                245                 250                 255     





Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 

            260                 265                 270         





Gln Thr Phe Phe Gly Leu Tyr Lys Leu 

        275                 280     





<210>  57

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  57



Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 

1               5                   10                  15      





Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 

            20                  25                  30          





Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 

        35                  40                  45              





Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 

    50                  55                  60                  





Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 

65                  70                  75                  80  





Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 

                85                  90                  95      





Pro Lys Thr 

            





<210>  58

<211>  277

<212>  PRT

<213>  Homo sapiens



<400>  58



Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 

1               5                   10                  15      





Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 

            20                  25                  30          





Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 

        35                  40                  45              





Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 

    50                  55                  60                  





Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 

65                  70                  75                  80  





Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 

                85                  90                  95      





Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 

            100                 105                 110         





Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 

        115                 120                 125             





Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 

    130                 135                 140                 





Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 

145                 150                 155                 160 





Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 

                165                 170                 175     





Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 

            180                 185                 190         





Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 

        195                 200                 205             





Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 

    210                 215                 220                 





Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 

225                 230                 235                 240 





Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 

                245                 250                 255     





Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 

            260                 265                 270         





Val Gln Glu Arg Gln 

        275         





<210>  59

<211>  244

<212>  PRT

<213>  Homo sapiens



<400>  59



Met Leu Leu Leu Gly Ala Val Leu Leu Leu Leu Ala Leu Pro Gly His 

1               5                   10                  15      





Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu Pro 

            20                  25                  30          





Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro Gly 

        35                  40                  45              





His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly Glu 

    50                  55                  60                  





Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp Ile 

65                  70                  75                  80  





Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro Gly 

                85                  90                  95      





Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Tyr Val Tyr Arg 

            100                 105                 110         





Ser Ala Phe Ser Val Gly Leu Glu Thr Tyr Val Thr Ile Pro Asn Met 

        115                 120                 125             





Pro Ile Arg Phe Thr Lys Ile Phe Tyr Asn Gln Gln Asn His Tyr Asp 

    130                 135                 140                 





Gly Ser Thr Gly Lys Phe His Cys Asn Ile Pro Gly Leu Tyr Tyr Phe 

145                 150                 155                 160 





Ala Tyr His Ile Thr Val Tyr Met Lys Asp Val Lys Val Ser Leu Phe 

                165                 170                 175     





Lys Lys Asp Lys Ala Met Leu Phe Thr Tyr Asp Gln Tyr Gln Glu Asn 

            180                 185                 190         





Asn Val Asp Gln Ala Ser Gly Ser Val Leu Leu His Leu Glu Val Gly 

        195                 200                 205             





Asp Gln Val Trp Leu Gln Val Tyr Gly Glu Gly Glu Arg Asn Gly Leu 

    210                 215                 220                 





Tyr Ala Asp Asn Asp Asn Asp Ser Thr Phe Thr Gly Phe Leu Leu Tyr 

225                 230                 235                 240 





His Asp Thr Asn 

                





<210>  60

<211>  458

<212>  PRT

<213>  Homo sapiens



<400>  60



Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 

1               5                   10                  15      





Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 

            20                  25                  30          





Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 

        35                  40                  45              





Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 

    50                  55                  60                  





Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 

65                  70                  75                  80  





Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 

                85                  90                  95      





Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 

            100                 105                 110         





Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 

        115                 120                 125             





Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 

    130                 135                 140                 





Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 

145                 150                 155                 160 





Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 

                165                 170                 175     





Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 

            180                 185                 190         





Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 

        195                 200                 205             





Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 

    210                 215                 220                 





Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 

225                 230                 235                 240 





Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 

                245                 250                 255     





Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 

            260                 265                 270         





Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 

        275                 280                 285             





Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 

    290                 295                 300                 





Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 

305                 310                 315                 320 





Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 

                325                 330                 335     





Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 

            340                 345                 350         





Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 

        355                 360                 365             





Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 

    370                 375                 380                 





Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 

385                 390                 395                 400 





Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 

                405                 410                 415     





Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 

            420                 425                 430         





Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 

        435                 440                 445             





His Arg Phe Gln Lys Thr Cys Ser Pro Ile 

    450                 455             





<210>  61

<211>  300

<212>  PRT

<213>  Homo sapiens



<400>  61



Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 

1               5                   10                  15      





Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 

            20                  25                  30          





Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 

        35                  40                  45              





Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 

    50                  55                  60                  





Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 

65                  70                  75                  80  





Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 

                85                  90                  95      





His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 

            100                 105                 110         





Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 

        115                 120                 125             





Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 

    130                 135                 140                 





Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 

145                 150                 155                 160 





Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 

                165                 170                 175     





Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 

            180                 185                 190         





Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 

        195                 200                 205             





Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 

    210                 215                 220                 





Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 

225                 230                 235                 240 





Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 

                245                 250                 255     





Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 

            260                 265                 270         





Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 

        275                 280                 285             





Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 

    290                 295                 300 





<210>  62

<211>  176

<212>  PRT

<213>  Homo sapiens



<400>  62



Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 

1               5                   10                  15      





Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 

            20                  25                  30          





Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 

        35                  40                  45              





Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 

    50                  55                  60                  





Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 

65                  70                  75                  80  





Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 

                85                  90                  95      





Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 

            100                 105                 110         





Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 

        115                 120                 125             





His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 

    130                 135                 140                 





Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 

145                 150                 155                 160 





Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 

                165                 170                 175     





<210>  63

<211>  728

<212>  PRT

<213>  Homo sapiens



<400>  63



Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 

1               5                   10                  15      





Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 

            20                  25                  30          





Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 

        35                  40                  45              





Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 

    50                  55                  60                  





Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 

65                  70                  75                  80  





Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 

                85                  90                  95      





Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 

            100                 105                 110         





Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 

        115                 120                 125             





Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 

    130                 135                 140                 





Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 

145                 150                 155                 160 





Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 

                165                 170                 175     





Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 

            180                 185                 190         





Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 

        195                 200                 205             





Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 

    210                 215                 220                 





His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 

225                 230                 235                 240 





His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 

                245                 250                 255     





Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 

            260                 265                 270         





Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 

        275                 280                 285             





Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 

    290                 295                 300                 





Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 

305                 310                 315                 320 





Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 

                325                 330                 335     





His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 

            340                 345                 350         





Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 

        355                 360                 365             





Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 

    370                 375                 380                 





Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 

385                 390                 395                 400 





Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 

                405                 410                 415     





Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 

            420                 425                 430         





Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 

        435                 440                 445             





Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 

    450                 455                 460                 





Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 

465                 470                 475                 480 





Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 

                485                 490                 495     





Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 

            500                 505                 510         





Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 

        515                 520                 525             





Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 

    530                 535                 540                 





Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 

545                 550                 555                 560 





Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 

                565                 570                 575     





Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 

            580                 585                 590         





Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 

        595                 600                 605             





Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 

    610                 615                 620                 





Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 

625                 630                 635                 640 





Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 

                645                 650                 655     





Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 

            660                 665                 670         





Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 

        675                 680                 685             





Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 

    690                 695                 700                 





Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 

705                 710                 715                 720 





Leu Thr Tyr Lys Val Pro Gln Ser 

                725             





<210>  64

<211>  534

<212>  PRT

<213>  Homo sapiens



<400>  64



Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 

1               5                   10                  15      





Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 

            20                  25                  30          





Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 

        35                  40                  45              





Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 

    50                  55                  60                  





Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 

65                  70                  75                  80  





Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 

                85                  90                  95      





Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 

            100                 105                 110         





Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 

        115                 120                 125             





Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 

    130                 135                 140                 





Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 

145                 150                 155                 160 





Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 

                165                 170                 175     





Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 

            180                 185                 190         





Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 

        195                 200                 205             





Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 

    210                 215                 220                 





Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 

225                 230                 235                 240 





Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 

                245                 250                 255     





Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 

            260                 265                 270         





Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 

        275                 280                 285             





Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 

    290                 295                 300                 





Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 

305                 310                 315                 320 





Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 

                325                 330                 335     





Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 

            340                 345                 350         





Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 

        355                 360                 365             





Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 

    370                 375                 380                 





Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 

385                 390                 395                 400 





Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 

                405                 410                 415     





Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 

            420                 425                 430         





Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 

        435                 440                 445             





Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 

    450                 455                 460                 





Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 

465                 470                 475                 480 





Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 

                485                 490                 495     





Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 

            500                 505                 510         





Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 

        515                 520                 525             





Asp Gly Gln Glu Ile Ala 

    530                 





<210>  65

<211>  223

<212>  PRT

<213>  Homo sapiens



<400>  65



Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 

1               5                   10                  15      





Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 

            20                  25                  30          





Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 

        35                  40                  45              





Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 

    50                  55                  60                  





Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 

65                  70                  75                  80  





Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 

                85                  90                  95      





Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 

            100                 105                 110         





Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 

        115                 120                 125             





Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 

    130                 135                 140                 





Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 

145                 150                 155                 160 





Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 

                165                 170                 175     





Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 

            180                 185                 190         





Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 

        195                 200                 205             





Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 

    210                 215                 220             





<210>  66

<211>  426

<212>  PRT

<213>  Homo sapiens



<400>  66



Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 

1               5                   10                  15      





Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 

            20                  25                  30          





Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 

        35                  40                  45              





Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 

    50                  55                  60                  





Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 

65                  70                  75                  80  





Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 

                85                  90                  95      





Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 

            100                 105                 110         





Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 

        115                 120                 125             





Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 

    130                 135                 140                 





Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 

145                 150                 155                 160 





Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 

                165                 170                 175     





Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 

            180                 185                 190         





Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 

        195                 200                 205             





Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 

    210                 215                 220                 





Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 

225                 230                 235                 240 





Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 

                245                 250                 255     





Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 

            260                 265                 270         





Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 

        275                 280                 285             





His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 

    290                 295                 300                 





His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 

305                 310                 315                 320 





Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 

                325                 330                 335     





Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 

            340                 345                 350         





Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 

        355                 360                 365             





His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 

    370                 375                 380                 





Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 

385                 390                 395                 400 





Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 

                405                 410                 415     





Asn Met Ile Val Glu Glu Cys Gly Cys Ser 

            420                 425     





<210>  67

<211>  293

<212>  PRT

<213>  Homo sapiens



<400>  67



Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 

1               5                   10                  15      





Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 

            20                  25                  30          





Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 

        35                  40                  45              





Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 

    50                  55                  60                  





Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 

65                  70                  75                  80  





His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 

                85                  90                  95      





Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 

            100                 105                 110         





Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 

        115                 120                 125             





Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 

    130                 135                 140                 





Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 

145                 150                 155                 160 





Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 

                165                 170                 175     





Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 

            180                 185                 190         





Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 

        195                 200                 205             





Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 

    210                 215                 220                 





Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 

225                 230                 235                 240 





Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 

                245                 250                 255     





Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 

            260                 265                 270         





His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 

        275                 280                 285             





Gly Gly Pro Gly Ala 

    290             





<210>  68

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  68



Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 

1               5                   10                  15      





Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 

            20                  25                  30          





Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 

        35                  40                  45              





Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 

    50                  55                  60                  





Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 

65                  70                  75                  80  





Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 

                85                  90                  95      





Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 

            100                 105                 110         





Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 

        115                 120                 125             





Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 

    130                 135                 140                 





Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 

145                 150                 155                 160 





Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 

                165                 170                 175     





Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 

            180                 185                 190         





Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 

        195                 200                 205             





Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 

    210                 215                 220                 





Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 

225                 230                 235                 240 





Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 

                245                 250                 255     





His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 

            260                 265                 270         





Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 

        275                 280                 285             





Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 

    290                 295                 300                 





Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 

305                 310                 





<210>  69

<211>  127

<212>  PRT

<213>  Homo sapiens



<400>  69



Met Gln Gln Arg Gly Leu Ala Ile Val Ala Leu Ala Val Cys Ala Ala 

1               5                   10                  15      





Leu His Ala Ser Glu Ala Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr 

            20                  25                  30          





Glu Val Ser His His Ile Ser Arg Arg Leu Leu Glu Arg Val Asn Met 

        35                  40                  45              





Cys Arg Ile Gln Arg Ala Asp Gly Asp Cys Asp Leu Ala Ala Val Ile 

    50                  55                  60                  





Leu His Val Lys Arg Arg Arg Ile Cys Val Ser Pro His Asn His Thr 

65                  70                  75                  80  





Val Lys Gln Trp Met Lys Val Gln Ala Ala Lys Lys Asn Gly Lys Gly 

                85                  90                  95      





Asn Val Cys His Arg Lys Lys His His Gly Lys Arg Asn Ser Asn Arg 

            100                 105                 110         





Ala His Gln Gly Lys His Glu Thr Tyr Gly His Lys Thr Pro Tyr 

        115                 120                 125         





<210>  70

<211>  166

<212>  PRT

<213>  Homo sapiens



<400>  70



Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 

1               5                   10                  15      





Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 

            20                  25                  30          





Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 

        35                  40                  45              





Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 

    50                  55                  60                  





Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 

65                  70                  75                  80  





Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 

                85                  90                  95      





Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 

            100                 105                 110         





Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 

        115                 120                 125             





Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 

    130                 135                 140                 





Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 

145                 150                 155                 160 





Gly Arg Arg Ala Ser Gln 

                165     





<210>  71

<211>  1663

<212>  PRT

<213>  Homo sapiens



<400>  71



Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 

1               5                   10                  15      





Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 

            20                  25                  30          





Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 

        35                  40                  45              





Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 

    50                  55                  60                  





Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 

65                  70                  75                  80  





Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 

                85                  90                  95      





Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 

            100                 105                 110         





Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 

        115                 120                 125             





Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 

    130                 135                 140                 





Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 

145                 150                 155                 160 





Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 

                165                 170                 175     





Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 

            180                 185                 190         





Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 

        195                 200                 205             





Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 

    210                 215                 220                 





Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 

225                 230                 235                 240 





Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 

                245                 250                 255     





Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 

            260                 265                 270         





Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 

        275                 280                 285             





Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 

    290                 295                 300                 





Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 

305                 310                 315                 320 





Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 

                325                 330                 335     





Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 

            340                 345                 350         





Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 

        355                 360                 365             





Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 

    370                 375                 380                 





Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 

385                 390                 395                 400 





Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 

                405                 410                 415     





Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 

            420                 425                 430         





Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 

        435                 440                 445             





Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 

    450                 455                 460                 





Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 

465                 470                 475                 480 





Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 

                485                 490                 495     





Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 

            500                 505                 510         





Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 

        515                 520                 525             





Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 

    530                 535                 540                 





Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 

545                 550                 555                 560 





Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 

                565                 570                 575     





Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 

            580                 585                 590         





Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 

        595                 600                 605             





Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 

    610                 615                 620                 





Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 

625                 630                 635                 640 





Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 

                645                 650                 655     





Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 

            660                 665                 670         





Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 

        675                 680                 685             





Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 

    690                 695                 700                 





Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 

705                 710                 715                 720 





Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 

                725                 730                 735     





Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 

            740                 745                 750         





Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 

        755                 760                 765             





Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 

    770                 775                 780                 





Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 

785                 790                 795                 800 





Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 

                805                 810                 815     





Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 

            820                 825                 830         





Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 

        835                 840                 845             





Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 

    850                 855                 860                 





Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 

865                 870                 875                 880 





Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 

                885                 890                 895     





Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 

            900                 905                 910         





Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 

        915                 920                 925             





Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 

    930                 935                 940                 





Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 

945                 950                 955                 960 





Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 

                965                 970                 975     





Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 

            980                 985                 990         





Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 

        995                 1000                 1005             





Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 

    1010                 1015                 1020             





Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 

    1025                 1030                 1035             





Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 

    1040                 1045                 1050             





Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 

    1055                 1060                 1065             





Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 

    1070                 1075                 1080             





Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 

    1085                 1090                 1095             





Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 

    1100                 1105                 1110             





Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 

    1115                 1120                 1125             





Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 

    1130                 1135                 1140             





Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 

    1145                 1150                 1155             





Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 

    1160                 1165                 1170             





Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 

    1175                 1180                 1185             





Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 

    1190                 1195                 1200             





Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 

    1205                 1210                 1215             





Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 

    1220                 1225                 1230             





Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 

    1235                 1240                 1245             





Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 

    1250                 1255                 1260             





Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 

    1265                 1270                 1275             





Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 

    1280                 1285                 1290             





Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 

    1295                 1300                 1305             





His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 

    1310                 1315                 1320             





Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 

    1325                 1330                 1335             





Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 

    1340                 1345                 1350             





Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 

    1355                 1360                 1365             





Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 

    1370                 1375                 1380             





Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 

    1385                 1390                 1395             





Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 

    1400                 1405                 1410             





Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 

    1415                 1420                 1425             





Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 

    1430                 1435                 1440             





Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 

    1445                 1450                 1455             





Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 

    1460                 1465                 1470             





Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 

    1475                 1480                 1485             





Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 

    1490                 1495                 1500             





Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 

    1505                 1510                 1515             





Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 

    1520                 1525                 1530             





Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 

    1535                 1540                 1545             





Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 

    1550                 1555                 1560             





Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 

    1565                 1570                 1575             





Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 

    1580                 1585                 1590             





Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 

    1595                 1600                 1605             





Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 

    1610                 1615                 1620             





Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 

    1625                 1630                 1635             





Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 

    1640                 1645                 1650             





Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 

    1655                 1660             





<210>  72

<211>  205

<212>  PRT

<213>  Homo sapiens



<400>  72



Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 

1               5                   10                  15      





Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 

            20                  25                  30          





Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 

        35                  40                  45              





Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 

    50                  55                  60                  





Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 

65                  70                  75                  80  





Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 

                85                  90                  95      





Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 

            100                 105                 110         





Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 

        115                 120                 125             





Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 

    130                 135                 140                 





His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 

145                 150                 155                 160 





Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 

                165                 170                 175     





Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 

            180                 185                 190         





Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 

        195                 200                 205 





<210>  73

<211>  289

<212>  PRT

<213>  Homo sapiens



<400>  73



Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 

1               5                   10                  15      





Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 

            20                  25                  30          





Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 

        35                  40                  45              





Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 

    50                  55                  60                  





Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 

65                  70                  75                  80  





Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 

                85                  90                  95      





Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 

            100                 105                 110         





Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 

        115                 120                 125             





Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 

    130                 135                 140                 





Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 

145                 150                 155                 160 





Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 

                165                 170                 175     





Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 

            180                 185                 190         





Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 

        195                 200                 205             





Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 

    210                 215                 220                 





Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 

225                 230                 235                 240 





Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 

                245                 250                 255     





Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 

            260                 265                 270         





Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 

        275                 280                 285             





Ser 

    





<210>  74

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  74



Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 

1               5                   10                  15      





Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 

            20                  25                  30          





Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 

        35                  40                  45              





Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 

    50                  55                  60                  





Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 

65                  70                  75                  80  





Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 

                85                  90                  95      





Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 

            100                 105                 110         





Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 

        115                 120                 125             





Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 

    130                 135                 140                 





Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 

145                 150                 155                 160 





Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 

                165                 170     





<210>  75

<211>  207

<212>  PRT

<213>  Homo sapiens



<400>  75



Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 

1               5                   10                  15      





Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 

            20                  25                  30          





Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 

        35                  40                  45              





Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 

    50                  55                  60                  





Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 

65                  70                  75                  80  





His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 

                85                  90                  95      





Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 

            100                 105                 110         





Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 

        115                 120                 125             





Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 

    130                 135                 140                 





Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 

145                 150                 155                 160 





Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 

                165                 170                 175     





Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 

            180                 185                 190         





Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 

        195                 200                 205         





<210>  76

<211>  182

<212>  PRT

<213>  Homo sapiens



<400>  76



Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 

1               5                   10                  15      





Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 

            20                  25                  30          





Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 

        35                  40                  45              





Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 

    50                  55                  60                  





Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 

65                  70                  75                  80  





Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 

                85                  90                  95      





Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 

            100                 105                 110         





Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 

        115                 120                 125             





Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 

    130                 135                 140                 





Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 

145                 150                 155                 160 





Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 

                165                 170                 175     





Asn Gln Leu Arg Arg Asn 

            180         





<210>  77

<211>  335

<212>  PRT

<213>  Homo sapiens



<400>  77



Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 

1               5                   10                  15      





Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 

            20                  25                  30          





Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 

        35                  40                  45              





Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 

    50                  55                  60                  





Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 

65                  70                  75                  80  





Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 

                85                  90                  95      





Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 

            100                 105                 110         





Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 

        115                 120                 125             





Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 

    130                 135                 140                 





Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 

145                 150                 155                 160 





Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 

                165                 170                 175     





Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 

            180                 185                 190         





Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 

        195                 200                 205             





Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 

    210                 215                 220                 





Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 

225                 230                 235                 240 





Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 

                245                 250                 255     





Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 

            260                 265                 270         





Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 

        275                 280                 285             





Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 

    290                 295                 300                 





Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 

305                 310                 315                 320 





Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 

                325                 330                 335 





<210>  78

<211>  285

<212>  PRT

<213>  Homo sapiens



<400>  78



Met Val Met Arg Pro Leu Trp Ser Leu Leu Leu Trp Glu Ala Leu Leu 

1               5                   10                  15      





Pro Ile Thr Val Thr Gly Ala Gln Val Leu Ser Lys Val Gly Gly Ser 

            20                  25                  30          





Val Leu Leu Val Ala Ala Arg Pro Pro Gly Phe Gln Val Arg Glu Ala 

        35                  40                  45              





Ile Trp Arg Ser Leu Trp Pro Ser Glu Glu Leu Leu Ala Thr Phe Phe 

    50                  55                  60                  





Arg Gly Ser Leu Glu Thr Leu Tyr His Ser Arg Phe Leu Gly Arg Ala 

65                  70                  75                  80  





Gln Leu His Ser Asn Leu Ser Leu Glu Leu Gly Pro Leu Glu Ser Gly 

                85                  90                  95      





Asp Ser Gly Asn Phe Ser Val Leu Met Val Asp Thr Arg Gly Gln Pro 

            100                 105                 110         





Trp Thr Gln Thr Leu Gln Leu Lys Val Tyr Asp Ala Val Pro Arg Pro 

        115                 120                 125             





Val Val Gln Val Phe Ile Ala Val Glu Arg Asp Ala Gln Pro Ser Lys 

    130                 135                 140                 





Thr Cys Gln Val Phe Leu Ser Cys Trp Ala Pro Asn Ile Ser Glu Ile 

145                 150                 155                 160 





Thr Tyr Ser Trp Arg Arg Glu Thr Thr Met Asp Phe Gly Met Glu Pro 

                165                 170                 175     





His Ser Leu Phe Thr Asp Gly Gln Val Leu Ser Ile Ser Leu Gly Pro 

            180                 185                 190         





Gly Asp Arg Asp Val Ala Tyr Ser Cys Ile Val Ser Asn Pro Val Ser 

        195                 200                 205             





Trp Asp Leu Ala Thr Val Thr Pro Trp Asp Ser Cys His His Glu Ala 

    210                 215                 220                 





Ala Pro Gly Lys Ala Ser Tyr Lys Asp Val Leu Leu Val Val Val Pro 

225                 230                 235                 240 





Val Ser Leu Leu Leu Met Leu Val Thr Leu Phe Ser Ala Trp His Trp 

                245                 250                 255     





Cys Pro Cys Ser Gly Lys Lys Lys Lys Asp Val His Ala Asp Arg Val 

            260                 265                 270         





Gly Pro Glu Thr Glu Asn Pro Leu Val Gln Asp Leu Pro 

        275                 280                 285 





<210>  79

<211>  858

<212>  PRT

<213>  Homo sapiens



<400>  79



Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 

1               5                   10                  15      





Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 

            20                  25                  30          





Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 

        35                  40                  45              





Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 

    50                  55                  60                  





Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 

65                  70                  75                  80  





Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 

                85                  90                  95      





Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 

            100                 105                 110         





Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 

        115                 120                 125             





Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 

    130                 135                 140                 





Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 

145                 150                 155                 160 





Lys Lys Asp Val Arg Phe Ile Val Leu Ser Asn Asn Tyr Leu Gln Ile 

                165                 170                 175     





Arg Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 

            180                 185                 190         





Ile Leu Ala Arg Gly Glu Ile Asn Phe Lys Asp Ile Gln Val Ile Val 

        195                 200                 205             





Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 

    210                 215                 220                 





Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 

225                 230                 235                 240 





Pro Glu Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 

                245                 250                 255     





Glu Glu Asp Asp Glu Lys Tyr Ile Phe Ser Asp Asp Ser Ser Gln Leu 

            260                 265                 270         





Thr Ile Lys Lys Val Asp Lys Asn Asp Glu Ala Glu Tyr Ile Cys Ile 

        275                 280                 285             





Ala Glu Asn Lys Ala Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 

    290                 295                 300                 





Phe Ala Lys Pro Lys Ile Thr Tyr Val Glu Asn Gln Thr Ala Met Glu 

305                 310                 315                 320 





Leu Glu Glu Gln Val Thr Leu Thr Cys Glu Ala Ser Gly Asp Pro Ile 

                325                 330                 335     





Pro Ser Ile Thr Trp Arg Thr Ser Thr Arg Asn Ile Ser Ser Glu Glu 

            340                 345                 350         





Lys Ala Ser Trp Thr Arg Pro Glu Lys Gln Glu Thr Leu Asp Gly His 

        355                 360                 365             





Met Val Val Arg Ser His Ala Arg Val Ser Ser Leu Thr Leu Lys Ser 

    370                 375                 380                 





Ile Gln Tyr Thr Asp Ala Gly Glu Tyr Ile Cys Thr Ala Ser Asn Thr 

385                 390                 395                 400 





Ile Gly Gln Asp Ser Gln Ser Met Tyr Leu Glu Val Gln Tyr Ala Pro 

                405                 410                 415     





Lys Leu Gln Gly Pro Val Ala Val Tyr Thr Trp Glu Gly Asn Gln Val 

            420                 425                 430         





Asn Ile Thr Cys Glu Val Phe Ala Tyr Pro Ser Ala Thr Ile Ser Trp 

        435                 440                 445             





Phe Arg Asp Gly Gln Leu Leu Pro Ser Ser Asn Tyr Ser Asn Ile Lys 

    450                 455                 460                 





Ile Tyr Asn Thr Pro Ser Ala Ser Tyr Leu Glu Val Thr Pro Asp Ser 

465                 470                 475                 480 





Glu Asn Asp Phe Gly Asn Tyr Asn Cys Thr Ala Val Asn Arg Ile Gly 

                485                 490                 495     





Gln Glu Ser Leu Glu Phe Ile Leu Val Gln Ala Asp Thr Pro Ser Ser 

            500                 505                 510         





Pro Ser Ile Asp Gln Val Glu Pro Tyr Ser Ser Thr Ala Gln Val Gln 

        515                 520                 525             





Phe Asp Glu Pro Glu Ala Thr Gly Gly Val Pro Ile Leu Lys Tyr Lys 

    530                 535                 540                 





Ala Glu Trp Arg Ala Val Gly Glu Glu Val Trp His Ser Lys Trp Tyr 

545                 550                 555                 560 





Asp Ala Lys Glu Ala Ser Met Glu Gly Ile Val Thr Ile Val Gly Leu 

                565                 570                 575     





Lys Pro Glu Thr Thr Tyr Ala Val Arg Leu Ala Ala Leu Asn Gly Lys 

            580                 585                 590         





Gly Leu Gly Glu Ile Ser Ala Ala Ser Glu Phe Lys Thr Gln Pro Val 

        595                 600                 605             





Gln Gly Glu Pro Ser Ala Pro Lys Leu Glu Gly Gln Met Gly Glu Asp 

    610                 615                 620                 





Gly Asn Ser Ile Lys Val Asn Leu Ile Lys Gln Asp Asp Gly Gly Ser 

625                 630                 635                 640 





Pro Ile Arg His Tyr Leu Val Arg Tyr Arg Ala Leu Ser Ser Glu Trp 

                645                 650                 655     





Lys Pro Glu Ile Arg Leu Pro Ser Gly Ser Asp His Val Met Leu Lys 

            660                 665                 670         





Ser Leu Asp Trp Asn Ala Glu Tyr Glu Val Tyr Val Val Ala Glu Asn 

        675                 680                 685             





Gln Gln Gly Lys Ser Lys Ala Ala His Phe Val Phe Arg Thr Ser Ala 

    690                 695                 700                 





Gln Pro Thr Ala Ile Pro Ala Asn Gly Ser Pro Thr Ser Gly Leu Ser 

705                 710                 715                 720 





Thr Gly Ala Ile Val Gly Ile Leu Ile Val Ile Phe Val Leu Leu Leu 

                725                 730                 735     





Val Val Val Asp Ile Thr Cys Tyr Phe Leu Asn Lys Cys Gly Leu Phe 

            740                 745                 750         





Met Cys Ile Ala Val Asn Leu Cys Gly Lys Ala Gly Pro Gly Ala Lys 

        755                 760                 765             





Gly Lys Asp Met Glu Glu Gly Lys Ala Ala Phe Ser Lys Asp Glu Ser 

    770                 775                 780                 





Lys Glu Pro Ile Val Glu Val Arg Thr Glu Glu Glu Arg Thr Pro Asn 

785                 790                 795                 800 





His Asp Gly Gly Lys His Thr Glu Pro Asn Glu Thr Thr Pro Leu Thr 

                805                 810                 815     





Glu Pro Glu Lys Gly Pro Val Glu Ala Lys Pro Glu Cys Gln Glu Thr 

            820                 825                 830         





Glu Thr Lys Pro Ala Pro Ala Glu Val Lys Thr Val Pro Asn Asp Ala 

        835                 840                 845             





Thr Gln Thr Lys Glu Asn Glu Ser Lys Ala 

    850                 855             





<210>  80

<211>  200

<212>  PRT

<213>  Homo sapiens



<400>  80



Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 

1               5                   10                  15      





Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 

            20                  25                  30          





Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 

        35                  40                  45              





Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 

    50                  55                  60                  





Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 

65                  70                  75                  80  





Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 

                85                  90                  95      





Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 

            100                 105                 110         





Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 

        115                 120                 125             





Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 

    130                 135                 140                 





Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 

145                 150                 155                 160 





Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 

                165                 170                 175     





Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 

            180                 185                 190         





Val Ala Ser Gly Asp Leu Cys Val 

        195                 200 





<210>  81

<211>  503

<212>  PRT

<213>  Homo sapiens



<400>  81



Met Leu Ser Gln Leu Ala Met Leu Gln Gly Ser Leu Leu Leu Val Val 

1               5                   10                  15      





Ala Thr Met Ser Val Ala Gln Gln Thr Arg Gln Glu Ala Asp Arg Gly 

            20                  25                  30          





Cys Glu Thr Leu Val Val Gln His Gly His Cys Ser Tyr Thr Phe Leu 

        35                  40                  45              





Leu Pro Lys Ser Glu Pro Cys Pro Pro Gly Pro Glu Val Ser Arg Asp 

    50                  55                  60                  





Ser Asn Thr Leu Gln Arg Glu Ser Leu Ala Asn Pro Leu His Leu Gly 

65                  70                  75                  80  





Lys Leu Pro Thr Gln Gln Val Lys Gln Leu Glu Gln Ala Leu Gln Asn 

                85                  90                  95      





Asn Thr Gln Trp Leu Lys Lys Leu Glu Arg Ala Ile Lys Thr Ile Leu 

            100                 105                 110         





Arg Ser Lys Leu Glu Gln Val Gln Gln Gln Met Ala Gln Asn Gln Thr 

        115                 120                 125             





Ala Pro Met Leu Glu Leu Gly Thr Ser Leu Leu Asn Gln Thr Thr Ala 

    130                 135                 140                 





Gln Ile Arg Lys Leu Thr Asp Met Glu Ala Gln Leu Leu Asn Gln Thr 

145                 150                 155                 160 





Ser Arg Met Asp Ala Gln Met Pro Glu Thr Phe Leu Ser Thr Asn Lys 

                165                 170                 175     





Leu Glu Asn Gln Leu Leu Leu Gln Arg Gln Lys Leu Gln Gln Leu Gln 

            180                 185                 190         





Gly Gln Asn Ser Ala Leu Glu Lys Arg Leu Gln Ala Leu Glu Thr Lys 

        195                 200                 205             





Gln Gln Glu Glu Leu Ala Ser Ile Leu Ser Lys Lys Ala Lys Leu Leu 

    210                 215                 220                 





Asn Thr Leu Ser Arg Gln Ser Ala Ala Leu Thr Asn Ile Glu Arg Gly 

225                 230                 235                 240 





Leu Arg Gly Val Arg His Asn Ser Ser Leu Leu Gln Asp Gln Gln His 

                245                 250                 255     





Ser Leu Arg Gln Leu Leu Val Leu Leu Arg His Leu Val Gln Glu Arg 

            260                 265                 270         





Ala Asn Ala Ser Ala Pro Ala Phe Ile Met Ala Gly Glu Gln Val Phe 

        275                 280                 285             





Gln Asp Cys Ala Glu Ile Gln Arg Ser Gly Ala Ser Ala Ser Gly Val 

    290                 295                 300                 





Tyr Thr Ile Gln Val Ser Asn Ala Thr Lys Pro Arg Lys Val Phe Cys 

305                 310                 315                 320 





Asp Leu Gln Ser Ser Gly Gly Arg Trp Thr Leu Ile Gln Arg Arg Glu 

                325                 330                 335     





Asn Gly Thr Val Asn Phe Gln Arg Asn Trp Lys Asp Tyr Lys Gln Gly 

            340                 345                 350         





Phe Gly Asp Pro Ala Gly Glu His Trp Leu Gly Asn Glu Val Val His 

        355                 360                 365             





Gln Leu Thr Arg Arg Ala Ala Tyr Ser Leu Arg Val Glu Leu Gln Asp 

    370                 375                 380                 





Trp Glu Gly His Glu Ala Tyr Ala Gln Tyr Glu His Phe His Leu Gly 

385                 390                 395                 400 





Ser Glu Asn Gln Leu Tyr Arg Leu Ser Val Val Gly Tyr Ser Gly Ser 

                405                 410                 415     





Ala Gly Arg Gln Ser Ser Leu Val Leu Gln Asn Thr Ser Phe Ser Thr 

            420                 425                 430         





Leu Asp Ser Asp Asn Asp His Cys Leu Cys Lys Cys Ala Gln Val Met 

        435                 440                 445             





Ser Gly Gly Trp Trp Phe Asp Ala Cys Gly Leu Ser Asn Leu Asn Gly 

    450                 455                 460                 





Val Tyr Tyr His Ala Pro Asp Asn Lys Tyr Lys Met Asp Gly Ile Arg 

465                 470                 475                 480 





Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ala Ser Arg Met 

                485                 490                 495     





Met Ile Arg Pro Leu Asp Ile 

            500             





<210>  82

<211>  99

<212>  PRT

<213>  Homo sapiens



<400>  82



Met Lys Ala Ser Ala Ala Leu Leu Cys Leu Leu Leu Thr Ala Ala Ala 

1               5                   10                  15      





Phe Ser Pro Gln Gly Leu Ala Gln Pro Val Gly Ile Asn Thr Ser Thr 

            20                  25                  30          





Thr Cys Cys Tyr Arg Phe Ile Asn Lys Lys Ile Pro Lys Gln Arg Leu 

        35                  40                  45              





Glu Ser Tyr Arg Arg Thr Thr Ser Ser His Cys Pro Arg Glu Ala Val 

    50                  55                  60                  





Ile Phe Lys Thr Lys Leu Asp Lys Glu Ile Cys Ala Asp Pro Thr Gln 

65                  70                  75                  80  





Lys Trp Val Gln Asp Phe Met Lys His Leu Asp Lys Lys Thr Gln Thr 

                85                  90                  95      





Pro Lys Leu 

            





<210>  83

<211>  260

<212>  PRT

<213>  Homo sapiens



<400>  83



Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 

1               5                   10                  15      





Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 

            20                  25                  30          





Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 

        35                  40                  45              





Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 

    50                  55                  60                  





Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 

65                  70                  75                  80  





Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 

                85                  90                  95      





Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 

            100                 105                 110         





Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 

        115                 120                 125             





Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 

    130                 135                 140                 





Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 

145                 150                 155                 160 





Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 

                165                 170                 175     





His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 

            180                 185                 190         





Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 

        195                 200                 205             





Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 

    210                 215                 220                 





Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 

225                 230                 235                 240 





Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 

                245                 250                 255     





Gln Gly Thr Leu 

            260 





<210>  84

<211>  967

<212>  PRT

<213>  Homo sapiens



<400>  84



Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 

1               5                   10                  15      





Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 

            20                  25                  30          





Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 

        35                  40                  45              





Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 

    50                  55                  60                  





Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 

65                  70                  75                  80  





Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 

                85                  90                  95      





Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 

            100                 105                 110         





Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 

        115                 120                 125             





Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 

    130                 135                 140                 





Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 

145                 150                 155                 160 





Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 

                165                 170                 175     





Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 

            180                 185                 190         





Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 

        195                 200                 205             





Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 

    210                 215                 220                 





Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 

225                 230                 235                 240 





Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 

                245                 250                 255     





Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 

            260                 265                 270         





Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 

        275                 280                 285             





Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 

    290                 295                 300                 





Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 

305                 310                 315                 320 





Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 

                325                 330                 335     





Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 

            340                 345                 350         





Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 

        355                 360                 365             





Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 

    370                 375                 380                 





Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 

385                 390                 395                 400 





Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 

                405                 410                 415     





Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 

            420                 425                 430         





Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 

        435                 440                 445             





Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 

    450                 455                 460                 





Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 

465                 470                 475                 480 





Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 

                485                 490                 495     





Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 

            500                 505                 510         





Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 

        515                 520                 525             





Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 

    530                 535                 540                 





Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 

545                 550                 555                 560 





Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 

                565                 570                 575     





Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 

            580                 585                 590         





Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 

        595                 600                 605             





Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 

    610                 615                 620                 





Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 

625                 630                 635                 640 





Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 

                645                 650                 655     





Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 

            660                 665                 670         





Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 

        675                 680                 685             





Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 

    690                 695                 700                 





Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 

705                 710                 715                 720 





Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 

                725                 730                 735     





Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 

            740                 745                 750         





Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 

        755                 760                 765             





Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 

    770                 775                 780                 





Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 

785                 790                 795                 800 





Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 

                805                 810                 815     





Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 

            820                 825                 830         





Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 

        835                 840                 845             





Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 

    850                 855                 860                 





Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 

865                 870                 875                 880 





Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 

                885                 890                 895     





Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 

            900                 905                 910         





Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 

        915                 920                 925             





Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 

    930                 935                 940                 





Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 

945                 950                 955                 960 





Trp Phe Thr Glu Asn Ser Lys 

                965         





<210>  85

<211>  159

<212>  PRT

<213>  Homo sapiens



<400>  85



Met Phe Pro Phe Ala Leu Leu Tyr Val Leu Ser Val Ser Phe Arg Lys 

1               5                   10                  15      





Ile Phe Ile Leu Gln Leu Val Gly Leu Val Leu Thr Tyr Asp Phe Thr 

            20                  25                  30          





Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu Ser Thr Ile Ser 

        35                  40                  45              





Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser Thr Glu Phe Asn 

    50                  55                  60                  





Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu Thr Glu Ile Gln 

65                  70                  75                  80  





Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser Leu Ala Lys Glu 

                85                  90                  95      





Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile Trp Cys Pro Gly 

            100                 105                 110         





Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met Lys Lys Arg Arg 

        115                 120                 125             





Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln Val Ser Gln Leu 

    130                 135                 140                 





Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu Lys Gln Gln 

145                 150                 155                 





<210>  86

<211>  109

<212>  PRT

<213>  Homo sapiens



<400>  86



Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 

1               5                   10                  15      





Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 

            20                  25                  30          





Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 

        35                  40                  45              





Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 

    50                  55                  60                  





Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 

65                  70                  75                  80  





Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 

                85                  90                  95      





Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 

            100                 105                 





<210>  87

<211>  101

<212>  PRT

<213>  Homo sapiens



<400>  87



Met Ser Ser Ala Ala Gly Phe Cys Ala Ser Arg Pro Gly Leu Leu Phe 

1               5                   10                  15      





Leu Gly Leu Leu Leu Leu Pro Leu Val Val Ala Phe Ala Ser Ala Glu 

            20                  25                  30          





Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys Thr Thr Ser 

        35                  40                  45              





Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile Lys Ala Gly 

    50                  55                  60                  





Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys Asn Gly Arg 

65                  70                  75                  80  





Lys Ile Cys Leu Asp Leu Gln Ala Pro Leu Tyr Lys Lys Ile Ile Lys 

                85                  90                  95      





Lys Leu Leu Glu Ser 

            100     





<210>  88

<211>  401

<212>  PRT

<213>  Homo sapiens



<400>  88



Met Asn Asn Leu Leu Cys Cys Ala Leu Val Phe Leu Asp Ile Ser Ile 

1               5                   10                  15      





Lys Trp Thr Thr Gln Glu Thr Phe Pro Pro Lys Tyr Leu His Tyr Asp 

            20                  25                  30          





Glu Glu Thr Ser His Gln Leu Leu Cys Asp Lys Cys Pro Pro Gly Thr 

        35                  40                  45              





Tyr Leu Lys Gln His Cys Thr Ala Lys Trp Lys Thr Val Cys Ala Pro 

    50                  55                  60                  





Cys Pro Asp His Tyr Tyr Thr Asp Ser Trp His Thr Ser Asp Glu Cys 

65                  70                  75                  80  





Leu Tyr Cys Ser Pro Val Cys Lys Glu Leu Gln Tyr Val Lys Gln Glu 

                85                  90                  95      





Cys Asn Arg Thr His Asn Arg Val Cys Glu Cys Lys Glu Gly Arg Tyr 

            100                 105                 110         





Leu Glu Ile Glu Phe Cys Leu Lys His Arg Ser Cys Pro Pro Gly Phe 

        115                 120                 125             





Gly Val Val Gln Ala Gly Thr Pro Glu Arg Asn Thr Val Cys Lys Arg 

    130                 135                 140                 





Cys Pro Asp Gly Phe Phe Ser Asn Glu Thr Ser Ser Lys Ala Pro Cys 

145                 150                 155                 160 





Arg Lys His Thr Asn Cys Ser Val Phe Gly Leu Leu Leu Thr Gln Lys 

                165                 170                 175     





Gly Asn Ala Thr His Asp Asn Ile Cys Ser Gly Asn Ser Glu Ser Thr 

            180                 185                 190         





Gln Lys Cys Gly Ile Asp Val Thr Leu Cys Glu Glu Ala Phe Phe Arg 

        195                 200                 205             





Phe Ala Val Pro Thr Lys Phe Thr Pro Asn Trp Leu Ser Val Leu Val 

    210                 215                 220                 





Asp Asn Leu Pro Gly Thr Lys Val Asn Ala Glu Ser Val Glu Arg Ile 

225                 230                 235                 240 





Lys Arg Gln His Ser Ser Gln Glu Gln Thr Phe Gln Leu Leu Lys Leu 

                245                 250                 255     





Trp Lys His Gln Asn Lys Asp Gln Asp Ile Val Lys Lys Ile Ile Gln 

            260                 265                 270         





Asp Ile Asp Leu Cys Glu Asn Ser Val Gln Arg His Ile Gly His Ala 

        275                 280                 285             





Asn Leu Thr Phe Glu Gln Leu Arg Ser Leu Met Glu Ser Leu Pro Gly 

    290                 295                 300                 





Lys Lys Val Gly Ala Glu Asp Ile Glu Lys Thr Ile Lys Ala Cys Lys 

305                 310                 315                 320 





Pro Ser Asp Gln Ile Leu Lys Leu Leu Ser Leu Trp Arg Ile Lys Asn 

                325                 330                 335     





Gly Asp Gln Asp Thr Leu Lys Gly Leu Met His Ala Leu Lys His Ser 

            340                 345                 350         





Lys Thr Tyr His Phe Pro Lys Thr Val Thr Gln Ser Leu Lys Lys Thr 

        355                 360                 365             





Ile Arg Phe Leu His Ser Phe Thr Met Tyr Lys Leu Tyr Gln Lys Leu 

    370                 375                 380                 





Phe Leu Glu Met Ile Gly Asn Gln Val Gln Ser Val Lys Ile Ser Cys 

385                 390                 395                 400 





Leu 

    





<210>  89

<211>  179

<212>  PRT

<213>  Homo sapiens



<400>  89



Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 

1               5                   10                  15      





Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 

            20                  25                  30          





Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 

        35                  40                  45              





Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 

    50                  55                  60                  





Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 

65                  70                  75                  80  





His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 

                85                  90                  95      





Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 

            100                 105                 110         





Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 

        115                 120                 125             





Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 

    130                 135                 140                 





Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 

145                 150                 155                 160 





Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 

                165                 170                 175     





Ala Cys Ile 

            





<210>  90

<211>  1039

<212>  PRT

<213>  Homo sapiens



<400>  90



Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 

1               5                   10                  15      





Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 

            20                  25                  30          





Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 

        35                  40                  45              





Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 

    50                  55                  60                  





Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 

65                  70                  75                  80  





Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 

                85                  90                  95      





Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 

            100                 105                 110         





Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 

        115                 120                 125             





Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 

    130                 135                 140                 





Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 

145                 150                 155                 160 





Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 

                165                 170                 175     





Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 

            180                 185                 190         





Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 

        195                 200                 205             





Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 

    210                 215                 220                 





Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 

225                 230                 235                 240 





Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 

                245                 250                 255     





Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 

            260                 265                 270         





Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 

        275                 280                 285             





Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 

    290                 295                 300                 





Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 

305                 310                 315                 320 





Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 

                325                 330                 335     





Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 

            340                 345                 350         





Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 

        355                 360                 365             





His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 

    370                 375                 380                 





Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 

385                 390                 395                 400 





Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 

                405                 410                 415     





Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 

            420                 425                 430         





Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 

        435                 440                 445             





Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 

    450                 455                 460                 





Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 

465                 470                 475                 480 





Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 

                485                 490                 495     





Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 

            500                 505                 510         





Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 

        515                 520                 525             





Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 

    530                 535                 540                 





Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 

545                 550                 555                 560 





Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 

                565                 570                 575     





His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 

            580                 585                 590         





Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 

        595                 600                 605             





Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 

    610                 615                 620                 





Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 

625                 630                 635                 640 





Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 

                645                 650                 655     





Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 

            660                 665                 670         





Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 

        675                 680                 685             





His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 

    690                 695                 700                 





Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 

705                 710                 715                 720 





Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 

                725                 730                 735     





Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 

            740                 745                 750         





Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 

        755                 760                 765             





Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 

    770                 775                 780                 





Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 

785                 790                 795                 800 





Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 

                805                 810                 815     





Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 

            820                 825                 830         





His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 

        835                 840                 845             





Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 

    850                 855                 860                 





Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 

865                 870                 875                 880 





His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 

                885                 890                 895     





Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 

            900                 905                 910         





Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 

        915                 920                 925             





Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 

    930                 935                 940                 





Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 

945                 950                 955                 960 





Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 

                965                 970                 975     





Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 

            980                 985                 990         





Arg Ala Ile Pro Ile Trp Trp Val  Leu Val Gly Val Leu  Gly Gly Leu 

        995                 1000                 1005             





Leu Leu  Leu Thr Ile Leu Val  Leu Ala Met Trp Lys  Val Gly Phe 

    1010                 1015                 1020             





Phe Lys  Arg Asn Arg Pro Pro  Leu Glu Glu Asp Asp  Glu Glu Gly 

    1025                 1030                 1035             





Glu 

    





<210>  91

<211>  272

<212>  PRT

<213>  Homo sapiens



<400>  91



Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 

1               5                   10                  15      





Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 

            20                  25                  30          





His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 

        35                  40                  45              





Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 

    50                  55                  60                  





Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 

65                  70                  75                  80  





Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 

                85                  90                  95      





Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 

            100                 105                 110         





Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 

        115                 120                 125             





Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 

    130                 135                 140                 





Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 

145                 150                 155                 160 





Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 

                165                 170                 175     





Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 

            180                 185                 190         





Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 

        195                 200                 205             





Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 

    210                 215                 220                 





Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 

225                 230                 235                 240 





Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 

                245                 250                 255     





Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 

            260                 265                 270         





<210>  92

<211>  993

<212>  PRT

<213>  Homo sapiens



<400>  92



Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 

1               5                   10                  15      





Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 

            20                  25                  30          





Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 

        35                  40                  45              





Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 

    50                  55                  60                  





Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 

65                  70                  75                  80  





Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 

                85                  90                  95      





Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 

            100                 105                 110         





Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 

        115                 120                 125             





Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 

    130                 135                 140                 





Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 

145                 150                 155                 160 





Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 

                165                 170                 175     





Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 

            180                 185                 190         





Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 

        195                 200                 205             





Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 

    210                 215                 220                 





Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 

225                 230                 235                 240 





Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 

                245                 250                 255     





Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 

            260                 265                 270         





Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 

        275                 280                 285             





Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 

    290                 295                 300                 





Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 

305                 310                 315                 320 





Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 

                325                 330                 335     





Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 

            340                 345                 350         





Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 

        355                 360                 365             





Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 

    370                 375                 380                 





Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 

385                 390                 395                 400 





Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 

                405                 410                 415     





Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 

            420                 425                 430         





Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 

        435                 440                 445             





Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 

    450                 455                 460                 





Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 

465                 470                 475                 480 





Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 

                485                 490                 495     





Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 

            500                 505                 510         





Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 

        515                 520                 525             





Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 

    530                 535                 540                 





Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 

545                 550                 555                 560 





Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 

                565                 570                 575     





Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 

            580                 585                 590         





Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 

        595                 600                 605             





Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 

    610                 615                 620                 





Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 

625                 630                 635                 640 





Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 

                645                 650                 655     





Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 

            660                 665                 670         





Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 

        675                 680                 685             





Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 

    690                 695                 700                 





Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 

705                 710                 715                 720 





His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 

                725                 730                 735     





Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 

            740                 745                 750         





Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 

        755                 760                 765             





Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 

    770                 775                 780                 





Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 

785                 790                 795                 800 





Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 

                805                 810                 815     





Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 

            820                 825                 830         





Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 

        835                 840                 845             





Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 

    850                 855                 860                 





Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 

865                 870                 875                 880 





Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 

                885                 890                 895     





Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 

            900                 905                 910         





Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 

        915                 920                 925             





Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 

    930                 935                 940                 





Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 

945                 950                 955                 960 





Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 

                965                 970                 975     





Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 

            980                 985                 990         





Ser 

    





<210>  93

<211>  202

<212>  PRT

<213>  Homo sapiens



<400>  93



Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 

1               5                   10                  15      





Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 

            20                  25                  30          





Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 

        35                  40                  45              





Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 

    50                  55                  60                  





Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 

65                  70                  75                  80  





Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 

                85                  90                  95      





Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 

            100                 105                 110         





Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 

        115                 120                 125             





Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 

    130                 135                 140                 





Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 

145                 150                 155                 160 





Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 

                165                 170                 175     





Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 

            180                 185                 190         





Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 

        195                 200         





<210>  94

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  94



Met Ala Asn Leu Gly Cys Trp Met Leu Val Leu Phe Val Ala Thr Trp 

1               5                   10                  15      





Ser Asp Leu Gly Leu Cys Lys Lys Arg Pro Lys Pro Gly Gly Trp Asn 

            20                  25                  30          





Thr Gly Gly Ser Arg Tyr Pro Gly Gln Gly Ser Pro Gly Gly Asn Arg 

        35                  40                  45              





Tyr Pro Pro Gln Gly Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 

    50                  55                  60                  





Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Pro His Gly Gly Gly 

65                  70                  75                  80  





Trp Gly Gln Pro His Gly Gly Gly Trp Gly Gln Gly Gly Gly Thr His 

                85                  90                  95      





Ser Gln Trp Asn Lys Pro Ser Lys Pro Lys Thr Asn Met Lys His Met 

            100                 105                 110         





Ala Gly Ala Ala Ala Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr 

        115                 120                 125             





Met Leu Gly Ser Ala Met Ser Arg Pro Ile Ile His Phe Gly Ser Asp 

    130                 135                 140                 





Tyr Glu Asp Arg Tyr Tyr Arg Glu Asn Met His Arg Tyr Pro Asn Gln 

145                 150                 155                 160 





Val Tyr Tyr Arg Pro Met Asp Glu Tyr Ser Asn Gln Asn Asn Phe Val 

                165                 170                 175     





His Asp Cys Val Asn Ile Thr Ile Lys Gln His Thr Val Thr Thr Thr 

            180                 185                 190         





Thr Lys Gly Glu Asn Phe Thr Glu Thr Asp Val Lys Met Met Glu Arg 

        195                 200                 205             





Val Val Glu Gln Met Cys Ile Thr Gln Tyr Glu Arg Glu Ser Gln Ala 

    210                 215                 220                 





Tyr Tyr Gln Arg Gly Ser Ser Met Val Leu Phe Ser Ser Pro Pro Val 

225                 230                 235                 240 





Ile Leu Leu Ile Ser Phe Leu Ile Phe Leu Ile Val Gly 

                245                 250             





<210>  95

<211>  359

<212>  PRT

<213>  Homo sapiens



<400>  95



Met Ala Glu Ala Ile Thr Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 

1               5                   10                  15      





Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 

            20                  25                  30          





Asp Asp Gly Glu Ile Thr Tyr Glu Asn Val Gln Val Pro Ala Val Leu 

        35                  40                  45              





Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 

    50                  55                  60                  





Val Lys Ser Glu Gln Pro Thr Ala Ser Trp Arg Ala Val Thr Ser Pro 

65                  70                  75                  80  





Ala Val Gly Arg Ile Leu Pro Cys Arg Thr Thr Cys Leu Arg Tyr Leu 

                85                  90                  95      





Leu Leu Gly Leu Leu Leu Thr Cys Leu Leu Leu Gly Val Thr Ala Ile 

            100                 105                 110         





Cys Leu Gly Val Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr 

        115                 120                 125             





Asn Arg Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg 

    130                 135                 140                 





Leu Lys Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser 

145                 150                 155                 160 





Arg Arg Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg 

                165                 170                 175     





Ala His Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg 

            180                 185                 190         





Gln Lys Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala 

        195                 200                 205             





Leu Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe 

    210                 215                 220                 





Thr Cys Gly Ser Ala Asp Thr Cys Cys Pro Ser Gly Trp Ile Met His 

225                 230                 235                 240 





Gln Lys Ser Cys Phe Tyr Ile Ser Leu Thr Ser Lys Asn Trp Gln Glu 

                245                 250                 255     





Ser Gln Lys Gln Cys Glu Thr Leu Ser Ser Lys Leu Ala Thr Phe Ser 

            260                 265                 270         





Glu Ile Tyr Pro Gln Ser His Ser Tyr Tyr Phe Leu Asn Ser Leu Leu 

        275                 280                 285             





Pro Asn Gly Gly Ser Gly Asn Ser Tyr Trp Thr Gly Leu Ser Ser Asn 

    290                 295                 300                 





Lys Asp Trp Lys Leu Thr Asp Asp Thr Gln Arg Thr Arg Thr Tyr Ala 

305                 310                 315                 320 





Gln Ser Ser Lys Cys Asn Lys Val His Lys Thr Trp Ser Trp Trp Thr 

                325                 330                 335     





Leu Glu Ser Glu Ser Cys Arg Ser Ser Leu Pro Tyr Ile Cys Glu Met 

            340                 345                 350         





Thr Ala Phe Arg Phe Pro Asp 

        355                 





<210>  96

<211>  365

<212>  PRT

<213>  Homo sapiens



<400>  96



Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 

1               5                   10                  15      





Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 

            20                  25                  30          





Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 

        35                  40                  45              





Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 

    50                  55                  60                  





Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 

65                  70                  75                  80  





Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 

                85                  90                  95      





Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 

            100                 105                 110         





Glu Ala Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 

        115                 120                 125             





Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 

    130                 135                 140                 





Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 

145                 150                 155                 160 





Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Glu 

                165                 170                 175     





Ala Glu Gln Leu Arg Ala Tyr Leu Asp Gly Thr Cys Val Glu Trp Leu 

            180                 185                 190         





Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 

        195                 200                 205             





Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 

    210                 215                 220                 





Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 

225                 230                 235                 240 





Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 

                245                 250                 255     





Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 

            260                 265                 270         





Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 

        275                 280                 285             





Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 

    290                 295                 300                 





Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 

305                 310                 315                 320 





Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 

                325                 330                 335     





Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 

            340                 345                 350         





Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 

        355                 360                 365 





<210>  97

<211>  366

<212>  PRT

<213>  Homo sapiens



<400>  97



Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 

1               5                   10                  15      





Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 

            20                  25                  30          





Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 

        35                  40                  45              





Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 

    50                  55                  60                  





Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 

65                  70                  75                  80  





Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 

                85                  90                  95      





Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 

            100                 105                 110         





Glu Asp Gly Ser His Thr Leu Gln Arg Met Ser Gly Cys Asp Leu Gly 

        115                 120                 125             





Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 

    130                 135                 140                 





Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 

145                 150                 155                 160 





Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 

                165                 170                 175     





Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 

            180                 185                 190         





Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 

        195                 200                 205             





Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 

    210                 215                 220                 





Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 

225                 230                 235                 240 





Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 

                245                 250                 255     





Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 

            260                 265                 270         





Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 

        275                 280                 285             





Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 

    290                 295                 300                 





Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 

305                 310                 315                 320 





Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 

                325                 330                 335     





Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 

            340                 345                 350         





Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys Ala 

        355                 360                 365     





<210>  98

<211>  1152

<212>  PRT

<213>  Homo sapiens



<400>  98



Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 

1               5                   10                  15      





Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 

            20                  25                  30          





Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 

        35                  40                  45              





Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 

    50                  55                  60                  





Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 

65                  70                  75                  80  





Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 

                85                  90                  95      





Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 

            100                 105                 110         





Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 

        115                 120                 125             





Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 

    130                 135                 140                 





Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 

145                 150                 155                 160 





Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 

                165                 170                 175     





Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 

            180                 185                 190         





Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 

        195                 200                 205             





Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 

    210                 215                 220                 





Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 

225                 230                 235                 240 





Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 

                245                 250                 255     





Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 

            260                 265                 270         





Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 

        275                 280                 285             





Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 

    290                 295                 300                 





Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 

305                 310                 315                 320 





Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 

                325                 330                 335     





Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 

            340                 345                 350         





Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 

        355                 360                 365             





Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 

    370                 375                 380                 





Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 

385                 390                 395                 400 





Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 

                405                 410                 415     





Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 

            420                 425                 430         





Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 

        435                 440                 445             





Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 

    450                 455                 460                 





Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 

465                 470                 475                 480 





His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 

                485                 490                 495     





Pro Arg Gly Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu 

            500                 505                 510         





Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 

        515                 520                 525             





Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly 

    530                 535                 540                 





Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly 

545                 550                 555                 560 





Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu 

                565                 570                 575     





Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp 

            580                 585                 590         





Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly His 

        595                 600                 605             





Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met 

    610                 615                 620                 





Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp 

625                 630                 635                 640 





Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu His 

                645                 650                 655     





Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser 

            660                 665                 670         





Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg 

        675                 680                 685             





Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val 

    690                 695                 700                 





Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn 

705                 710                 715                 720 





Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser 

                725                 730                 735     





Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu 

            740                 745                 750         





Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys 

        755                 760                 765             





Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe 

    770                 775                 780                 





Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe 

785                 790                 795                 800 





Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr 

                805                 810                 815     





Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser 

            820                 825                 830         





Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu 

        835                 840                 845             





Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys 

    850                 855                 860                 





Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn 

865                 870                 875                 880 





Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu 

                885                 890                 895     





Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys 

            900                 905                 910         





Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val 

        915                 920                 925             





Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser 

    930                 935                 940                 





Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn Leu 

945                 950                 955                 960 





Gly Gln Arg Ser Leu Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg 

                965                 970                 975     





Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu 

            980                 985                 990         





Asn Leu Ser Ser Thr Cys His Thr  Lys Glu Arg Leu Pro  Ser His Ser 

        995                 1000                 1005             





Asp Phe  Leu Ala Glu Leu Arg  Lys Ala Pro Val Val  Asn Cys Ser 

    1010                 1015                 1020             





Ile Ala  Val Cys Gln Arg Ile  Gln Cys Asp Ile Pro  Phe Phe Gly 

    1025                 1030                 1035             





Ile Gln  Glu Glu Phe Asn Ala  Thr Leu Lys Gly Asn  Leu Ser Phe 

    1040                 1045                 1050             





Asp Trp  Tyr Ile Lys Thr Ser  His Asn His Leu Leu  Ile Val Ser 

    1055                 1060                 1065             





Thr Ala  Glu Ile Leu Phe Asn  Asp Ser Val Phe Thr  Leu Leu Pro 

    1070                 1075                 1080             





Gly Gln  Gly Ala Phe Val Arg  Ser Gln Thr Glu Thr  Lys Val Glu 

    1085                 1090                 1095             





Pro Phe  Glu Val Pro Asn Pro  Leu Pro Leu Ile Val  Gly Ser Ser 

    1100                 1105                 1110             





Val Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Ala Leu Tyr 

    1115                 1120                 1125             





Lys Leu  Gly Phe Phe Lys Arg  Gln Tyr Lys Asp Met  Met Ser Glu 

    1130                 1135                 1140             





Gly Gly  Pro Pro Gly Ala Glu  Pro Gln 

    1145                 1150         





<210>  99

<211>  252

<212>  PRT

<213>  Homo sapiens



<400>  99



Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 

1               5                   10                  15      





Leu Leu Phe Pro Ser Met Ala Ser Met Ala Ala Ile Gly Ser Cys Ser 

            20                  25                  30          





Lys Glu Tyr Arg Val Leu Leu Gly Gln Leu Gln Lys Gln Thr Asp Leu 

        35                  40                  45              





Met Gln Asp Thr Ser Arg Leu Leu Asp Pro Tyr Ile Arg Ile Gln Gly 

    50                  55                  60                  





Leu Asp Val Pro Lys Leu Arg Glu His Cys Arg Glu Arg Pro Gly Ala 

65                  70                  75                  80  





Phe Pro Ser Glu Glu Thr Leu Arg Gly Leu Gly Arg Arg Gly Phe Leu 

                85                  90                  95      





Gln Thr Leu Asn Ala Thr Leu Gly Cys Val Leu His Arg Leu Ala Asp 

            100                 105                 110         





Leu Glu Gln Arg Leu Pro Lys Ala Gln Asp Leu Glu Arg Ser Gly Leu 

        115                 120                 125             





Asn Ile Glu Asp Leu Glu Lys Leu Gln Met Ala Arg Pro Asn Ile Leu 

    130                 135                 140                 





Gly Leu Arg Asn Asn Ile Tyr Cys Met Ala Gln Leu Leu Asp Asn Ser 

145                 150                 155                 160 





Asp Thr Ala Glu Pro Thr Lys Ala Gly Arg Gly Ala Ser Gln Pro Pro 

                165                 170                 175     





Thr Pro Thr Pro Ala Ser Asp Ala Phe Gln Arg Lys Leu Glu Gly Cys 

            180                 185                 190         





Arg Phe Leu His Gly Tyr His Arg Phe Met His Ser Val Gly Arg Val 

        195                 200                 205             





Phe Ser Lys Trp Gly Glu Ser Pro Asn Arg Ser Arg Arg His Ser Pro 

    210                 215                 220                 





His Gln Ala Leu Arg Lys Gly Val Arg Arg Thr Arg Pro Ser Arg Lys 

225                 230                 235                 240 





Gly Lys Arg Leu Met Thr Arg Gly Gln Leu Pro Arg 

                245                 250         





<210>  100

<211>  375

<212>  PRT

<213>  Homo sapiens



<400>  100



Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 

1               5                   10                  15      





Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 

            20                  25                  30          





Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 

        35                  40                  45              





Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 

    50                  55                  60                  





Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 

65                  70                  75                  80  





Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 

                85                  90                  95      





Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 

            100                 105                 110         





Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 

        115                 120                 125             





Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 

    130                 135                 140                 





Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 

145                 150                 155                 160 





Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 

                165                 170                 175     





Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 

            180                 185                 190         





Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 

        195                 200                 205             





His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 

    210                 215                 220                 





Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 

225                 230                 235                 240 





Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 

                245                 250                 255     





Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 

            260                 265                 270         





Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 

        275                 280                 285             





Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 

    290                 295                 300                 





Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 

305                 310                 315                 320 





His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 

                325                 330                 335     





Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 

            340                 345                 350         





Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 

        355                 360                 365             





Ala Glu Ile Asn Pro Lys Val 

    370                 375 





<210>  101

<211>  835

<212>  PRT

<213>  Homo sapiens



<400>  101



Met Gly Gly Arg Val Phe Leu Ala Phe Cys Val Trp Leu Thr Leu Pro 

1               5                   10                  15      





Gly Ala Glu Thr Gln Asp Ser Arg Gly Cys Ala Arg Trp Cys Pro Gln 

            20                  25                  30          





Asn Ser Ser Cys Val Asn Ala Thr Ala Cys Arg Cys Asn Pro Gly Phe 

        35                  40                  45              





Ser Ser Phe Ser Glu Ile Ile Thr Thr Pro Thr Glu Thr Cys Asp Asp 

    50                  55                  60                  





Ile Asn Glu Cys Ala Thr Pro Ser Lys Val Ser Cys Gly Lys Phe Ser 

65                  70                  75                  80  





Asp Cys Trp Asn Thr Glu Gly Ser Tyr Asp Cys Val Cys Ser Pro Gly 

                85                  90                  95      





Tyr Glu Pro Val Ser Gly Ala Lys Thr Phe Lys Asn Glu Ser Glu Asn 

            100                 105                 110         





Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asn Pro Arg Leu Cys Lys 

        115                 120                 125             





Ser Tyr Gly Thr Cys Val Asn Thr Leu Gly Ser Tyr Thr Cys Gln Cys 

    130                 135                 140                 





Leu Pro Gly Phe Lys Phe Ile Pro Glu Asp Pro Lys Val Cys Thr Asp 

145                 150                 155                 160 





Val Asn Glu Cys Thr Ser Gly Gln Asn Pro Cys His Ser Ser Thr His 

                165                 170                 175     





Cys Leu Asn Asn Val Gly Ser Tyr Gln Cys Arg Cys Arg Pro Gly Trp 

            180                 185                 190         





Gln Pro Ile Pro Gly Ser Pro Asn Gly Pro Asn Asn Thr Val Cys Glu 

        195                 200                 205             





Asp Val Asp Glu Cys Ser Ser Gly Gln His Gln Cys Asp Ser Ser Thr 

    210                 215                 220                 





Val Cys Phe Asn Thr Val Gly Ser Tyr Ser Cys Arg Cys Arg Pro Gly 

225                 230                 235                 240 





Trp Lys Pro Arg His Gly Ile Pro Asn Asn Gln Lys Asp Thr Val Cys 

                245                 250                 255     





Glu Asp Met Thr Phe Ser Thr Trp Thr Pro Pro Pro Gly Val His Ser 

            260                 265                 270         





Gln Thr Leu Ser Arg Phe Phe Asp Lys Val Gln Asp Leu Gly Arg Asp 

        275                 280                 285             





Ser Lys Thr Ser Ser Ala Glu Val Thr Ile Gln Asn Val Ile Lys Leu 

    290                 295                 300                 





Val Asp Glu Leu Met Glu Ala Pro Gly Asp Val Glu Ala Leu Ala Pro 

305                 310                 315                 320 





Pro Val Arg His Leu Ile Ala Thr Gln Leu Leu Ser Asn Leu Glu Asp 

                325                 330                 335     





Ile Met Arg Ile Leu Ala Lys Ser Leu Pro Lys Gly Pro Phe Thr Tyr 

            340                 345                 350         





Ile Ser Pro Ser Asn Thr Glu Leu Thr Leu Met Ile Gln Glu Arg Gly 

        355                 360                 365             





Asp Lys Asn Val Thr Met Gly Gln Ser Ser Ala Arg Met Lys Leu Asn 

    370                 375                 380                 





Trp Ala Val Ala Ala Gly Ala Glu Asp Pro Gly Pro Ala Val Ala Gly 

385                 390                 395                 400 





Ile Leu Ser Ile Gln Asn Met Thr Thr Leu Leu Ala Asn Ala Ser Leu 

                405                 410                 415     





Asn Leu His Ser Lys Lys Gln Ala Glu Leu Glu Glu Ile Tyr Glu Ser 

            420                 425                 430         





Ser Ile Arg Gly Val Gln Leu Arg Arg Leu Ser Ala Val Asn Ser Ile 

        435                 440                 445             





Phe Leu Ser His Asn Asn Thr Lys Glu Leu Asn Ser Pro Ile Leu Phe 

    450                 455                 460                 





Ala Phe Ser His Leu Glu Ser Ser Asp Gly Glu Ala Gly Arg Asp Pro 

465                 470                 475                 480 





Pro Ala Lys Asp Val Met Pro Gly Pro Arg Gln Glu Leu Leu Cys Ala 

                485                 490                 495     





Phe Trp Lys Ser Asp Ser Asp Arg Gly Gly His Trp Ala Thr Glu Gly 

            500                 505                 510         





Cys Gln Val Leu Gly Ser Lys Asn Gly Ser Thr Thr Cys Gln Cys Ser 

        515                 520                 525             





His Leu Ser Ser Phe Ala Ile Leu Met Ala His Tyr Asp Val Glu Asp 

    530                 535                 540                 





Trp Lys Leu Thr Leu Ile Thr Arg Val Gly Leu Ala Leu Ser Leu Phe 

545                 550                 555                 560 





Cys Leu Leu Leu Cys Ile Leu Thr Phe Leu Leu Val Arg Pro Ile Gln 

                565                 570                 575     





Gly Ser Arg Thr Thr Ile His Leu His Leu Cys Ile Cys Leu Phe Val 

            580                 585                 590         





Gly Ser Thr Ile Phe Leu Ala Gly Ile Glu Asn Glu Gly Gly Gln Val 

        595                 600                 605             





Gly Leu Arg Cys Arg Leu Val Ala Gly Leu Leu His Tyr Cys Phe Leu 

    610                 615                 620                 





Ala Ala Phe Cys Trp Met Ser Leu Glu Gly Leu Glu Leu Tyr Phe Leu 

625                 630                 635                 640 





Val Val Arg Val Phe Gln Gly Gln Gly Leu Ser Thr Arg Trp Leu Cys 

                645                 650                 655     





Leu Ile Gly Tyr Gly Val Pro Leu Leu Ile Val Gly Val Ser Ala Ala 

            660                 665                 670         





Ile Tyr Ser Lys Gly Tyr Gly Arg Pro Arg Tyr Cys Trp Leu Asp Phe 

        675                 680                 685             





Glu Gln Gly Phe Leu Trp Ser Phe Leu Gly Pro Val Thr Phe Ile Ile 

    690                 695                 700                 





Leu Cys Asn Ala Val Ile Phe Val Thr Thr Val Trp Lys Leu Thr Gln 

705                 710                 715                 720 





Lys Phe Ser Glu Ile Asn Pro Asp Met Lys Lys Leu Lys Lys Ala Arg 

                725                 730                 735     





Ala Leu Thr Ile Thr Ala Ile Ala Gln Leu Phe Leu Leu Gly Cys Thr 

            740                 745                 750         





Trp Val Phe Gly Leu Phe Ile Phe Asp Asp Arg Ser Leu Val Leu Thr 

        755                 760                 765             





Tyr Val Phe Thr Ile Leu Asn Cys Leu Gln Gly Ala Phe Leu Tyr Leu 

    770                 775                 780                 





Leu His Cys Leu Leu Asn Lys Lys Val Arg Glu Glu Tyr Arg Lys Trp 

785                 790                 795                 800 





Ala Cys Leu Val Ala Gly Gly Ser Lys Tyr Ser Glu Phe Thr Ser Thr 

                805                 810                 815     





Thr Ser Gly Thr Gly His Asn Gln Thr Arg Ala Leu Arg Ala Ser Glu 

            820                 825                 830         





Ser Gly Ile 

        835 





<210>  102

<211>  658

<212>  PRT

<213>  Homo sapiens



<400>  102



Met Asp Arg Gly Thr Leu Pro Leu Ala Val Ala Leu Leu Leu Ala Ser 

1               5                   10                  15      





Cys Ser Leu Ser Pro Thr Ser Leu Ala Glu Thr Val His Cys Asp Leu 

            20                  25                  30          





Gln Pro Val Gly Pro Glu Arg Gly Glu Val Thr Tyr Thr Thr Ser Gln 

        35                  40                  45              





Val Ser Lys Gly Cys Val Ala Gln Ala Pro Asn Ala Ile Leu Glu Val 

    50                  55                  60                  





His Val Leu Phe Leu Glu Phe Pro Thr Gly Pro Ser Gln Leu Glu Leu 

65                  70                  75                  80  





Thr Leu Gln Ala Ser Lys Gln Asn Gly Thr Trp Pro Arg Glu Val Leu 

                85                  90                  95      





Leu Val Leu Ser Val Asn Ser Ser Val Phe Leu His Leu Gln Ala Leu 

            100                 105                 110         





Gly Ile Pro Leu His Leu Ala Tyr Asn Ser Ser Leu Val Thr Phe Gln 

        115                 120                 125             





Glu Pro Pro Gly Val Asn Thr Thr Glu Leu Pro Ser Phe Pro Lys Thr 

    130                 135                 140                 





Gln Ile Leu Glu Trp Ala Ala Glu Arg Gly Pro Ile Thr Ser Ala Ala 

145                 150                 155                 160 





Glu Leu Asn Asp Pro Gln Ser Ile Leu Leu Arg Leu Gly Gln Ala Gln 

                165                 170                 175     





Gly Ser Leu Ser Phe Cys Met Leu Glu Ala Ser Gln Asp Met Gly Arg 

            180                 185                 190         





Thr Leu Glu Trp Arg Pro Arg Thr Pro Ala Leu Val Arg Gly Cys His 

        195                 200                 205             





Leu Glu Gly Val Ala Gly His Lys Glu Ala His Ile Leu Arg Val Leu 

    210                 215                 220                 





Pro Gly His Ser Ala Gly Pro Arg Thr Val Thr Val Lys Val Glu Leu 

225                 230                 235                 240 





Ser Cys Ala Pro Gly Asp Leu Asp Ala Val Leu Ile Leu Gln Gly Pro 

                245                 250                 255     





Pro Tyr Val Ser Trp Leu Ile Asp Ala Asn His Asn Met Gln Ile Trp 

            260                 265                 270         





Thr Thr Gly Glu Tyr Ser Phe Lys Ile Phe Pro Glu Lys Asn Ile Arg 

        275                 280                 285             





Gly Phe Lys Leu Pro Asp Thr Pro Gln Gly Leu Leu Gly Glu Ala Arg 

    290                 295                 300                 





Met Leu Asn Ala Ser Ile Val Ala Ser Phe Val Glu Leu Pro Leu Ala 

305                 310                 315                 320 





Ser Ile Val Ser Leu His Ala Ser Ser Cys Gly Gly Arg Leu Gln Thr 

                325                 330                 335     





Ser Pro Ala Pro Ile Gln Thr Thr Pro Pro Lys Asp Thr Cys Ser Pro 

            340                 345                 350         





Glu Leu Leu Met Ser Leu Ile Gln Thr Lys Cys Ala Asp Asp Ala Met 

        355                 360                 365             





Thr Leu Val Leu Lys Lys Glu Leu Val Ala His Leu Lys Cys Thr Ile 

    370                 375                 380                 





Thr Gly Leu Thr Phe Trp Asp Pro Ser Cys Glu Ala Glu Asp Arg Gly 

385                 390                 395                 400 





Asp Lys Phe Val Leu Arg Ser Ala Tyr Ser Ser Cys Gly Met Gln Val 

                405                 410                 415     





Ser Ala Ser Met Ile Ser Asn Glu Ala Val Val Asn Ile Leu Ser Ser 

            420                 425                 430         





Ser Ser Pro Gln Arg Lys Lys Val His Cys Leu Asn Met Asp Ser Leu 

        435                 440                 445             





Ser Phe Gln Leu Gly Leu Tyr Leu Ser Pro His Phe Leu Gln Ala Ser 

    450                 455                 460                 





Asn Thr Ile Glu Pro Gly Gln Gln Ser Phe Val Gln Val Arg Val Ser 

465                 470                 475                 480 





Pro Ser Val Ser Glu Phe Leu Leu Gln Leu Asp Ser Cys His Leu Asp 

                485                 490                 495     





Leu Gly Pro Glu Gly Gly Thr Val Glu Leu Ile Gln Gly Arg Ala Ala 

            500                 505                 510         





Lys Gly Asn Cys Val Ser Leu Leu Ser Pro Ser Pro Glu Gly Asp Pro 

        515                 520                 525             





Arg Phe Ser Phe Leu Leu His Phe Tyr Thr Val Pro Ile Pro Lys Thr 

    530                 535                 540                 





Gly Thr Leu Ser Cys Thr Val Ala Leu Arg Pro Lys Thr Gly Ser Gln 

545                 550                 555                 560 





Asp Gln Glu Val His Arg Thr Val Phe Met Arg Leu Asn Ile Ile Ser 

                565                 570                 575     





Pro Asp Leu Ser Gly Cys Thr Ser Lys Gly Leu Val Leu Pro Ala Val 

            580                 585                 590         





Leu Gly Ile Thr Phe Gly Ala Phe Leu Ile Gly Ala Leu Leu Thr Ala 

        595                 600                 605             





Ala Leu Trp Tyr Ile Tyr Ser His Thr Arg Ser Pro Ser Lys Arg Glu 

    610                 615                 620                 





Pro Val Val Ala Val Ala Ala Pro Ala Ser Ser Glu Ser Ser Ser Thr 

625                 630                 635                 640 





Asn His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Thr Ser Ser 

                645                 650                 655     





Met Ala 

        





<210>  103

<211>  125

<212>  PRT

<213>  Homo sapiens



<400>  103



Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 

1               5                   10                  15      





Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 

            20                  25                  30          





Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 

        35                  40                  45              





Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 

    50                  55                  60                  





Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 

65                  70                  75                  80  





Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 

                85                  90                  95      





Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 

            100                 105                 110         





Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 

        115                 120                 125 





<210>  104

<211>  92

<212>  PRT

<213>  Homo sapiens



<400>  104



Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 

1               5                   10                  15      





Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 

            20                  25                  30          





Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 

        35                  40                  45              





Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 

    50                  55                  60                  





Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 

65                  70                  75                  80  





Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 

                85                  90          





<210>  105

<211>  478

<212>  PRT

<213>  Homo sapiens



<400>  105



Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 

1               5                   10                  15      





Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 

            20                  25                  30          





Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 

        35                  40                  45              





Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 

    50                  55                  60                  





Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 

65                  70                  75                  80  





Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 

                85                  90                  95      





Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 

            100                 105                 110         





Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 

        115                 120                 125             





Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 

    130                 135                 140                 





Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 

145                 150                 155                 160 





Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 

                165                 170                 175     





Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 

            180                 185                 190         





Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 

        195                 200                 205             





Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn 

    210                 215                 220                 





Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 

225                 230                 235                 240 





Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 

                245                 250                 255     





His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 

            260                 265                 270         





Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 

        275                 280                 285             





Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 

    290                 295                 300                 





Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly 

305                 310                 315                 320 





Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 

                325                 330                 335     





Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala 

            340                 345                 350         





Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp 

        355                 360                 365             





Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln 

    370                 375                 380                 





Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 

385                 390                 395                 400 





Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His 

                405                 410                 415     





Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr 

            420                 425                 430         





Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 

        435                 440                 445             





Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met 

    450                 455                 460                 





Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 

465                 470                 475             





<210>  106

<211>  224

<212>  PRT

<213>  Homo sapiens



<400>  106



Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 

1               5                   10                  15      





Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 

            20                  25                  30          





Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 

        35                  40                  45              





Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 

    50                  55                  60                  





Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 

65                  70                  75                  80  





Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 

                85                  90                  95      





Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 

            100                 105                 110         





His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 

        115                 120                 125             





Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 

    130                 135                 140                 





Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 

145                 150                 155                 160 





Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 

                165                 170                 175     





Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 

            180                 185                 190         





Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 

        195                 200                 205             





Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 

    210                 215                 220                 





<210>  107

<211>  1255

<212>  PRT

<213>  Homo sapiens



<400>  107



Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 

1               5                   10                  15      





Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 

            20                  25                  30          





Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 

        35                  40                  45              





Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 

    50                  55                  60                  





Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 

65                  70                  75                  80  





Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 

                85                  90                  95      





Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 

            100                 105                 110         





Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 

        115                 120                 125             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    130                 135                 140                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

145                 150                 155                 160 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                165                 170                 175     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            180                 185                 190         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        195                 200                 205             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    210                 215                 220                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

225                 230                 235                 240 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                245                 250                 255     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            260                 265                 270         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        275                 280                 285             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    290                 295                 300                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

305                 310                 315                 320 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                325                 330                 335     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            340                 345                 350         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        355                 360                 365             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    370                 375                 380                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

385                 390                 395                 400 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                405                 410                 415     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            420                 425                 430         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        435                 440                 445             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    450                 455                 460                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

465                 470                 475                 480 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                485                 490                 495     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            500                 505                 510         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        515                 520                 525             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    530                 535                 540                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

545                 550                 555                 560 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                565                 570                 575     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            580                 585                 590         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        595                 600                 605             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    610                 615                 620                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

625                 630                 635                 640 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                645                 650                 655     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            660                 665                 670         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        675                 680                 685             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    690                 695                 700                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

705                 710                 715                 720 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                725                 730                 735     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            740                 745                 750         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        755                 760                 765             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    770                 775                 780                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

785                 790                 795                 800 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                805                 810                 815     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            820                 825                 830         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        835                 840                 845             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 

    850                 855                 860                 





Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 

865                 870                 875                 880 





Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 

                885                 890                 895     





Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 

            900                 905                 910         





Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 

        915                 920                 925             





Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 

    930                 935                 940                 





Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 

945                 950                 955                 960 





Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 

                965                 970                 975     





Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 

            980                 985                 990         





Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 

        995                 1000                 1005             





Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 

    1010                 1015                 1020             





Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 

    1025                 1030                 1035             





Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 

    1040                 1045                 1050             





Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 

    1055                 1060                 1065             





Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 

    1070                 1075                 1080             





Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 

    1085                 1090                 1095             





Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 

    1100                 1105                 1110             





Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 

    1115                 1120                 1125             





Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 

    1130                 1135                 1140             





Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 

    1145                 1150                 1155             





Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 

    1160                 1165                 1170             





Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 

    1175                 1180                 1185             





Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 

    1190                 1195                 1200             





His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 

    1205                 1210                 1215             





Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 

    1220                 1225                 1230             





Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 

    1235                 1240                 1245             





Ala Ala  Thr Ser Ala Asn Leu  

    1250                 1255 





<210>  108

<211>  261

<212>  PRT

<213>  Homo sapiens



<400>  108



Met Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe 

1               5                   10                  15      





Phe Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu 

            20                  25                  30          





Gly Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys 

        35                  40                  45              





Lys Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln 

    50                  55                  60                  





Tyr Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His 

65                  70                  75                  80  





Val Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln 

                85                  90                  95      





Leu Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr 

            100                 105                 110         





Asp His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys 

        115                 120                 125             





Asp Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala 

    130                 135                 140                 





Glu Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly 

145                 150                 155                 160 





Lys Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn 

                165                 170                 175     





Phe Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn 

            180                 185                 190         





Lys Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu 

        195                 200                 205             





Asn Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln 

    210                 215                 220                 





Asp Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala 

225                 230                 235                 240 





Leu Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu 

                245                 250                 255     





Cys Ala Gly Asp Asn 

            260     





<210>  109

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  109



Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 

1               5                   10                  15      





Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 

            20                  25                  30          





Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 

        35                  40                  45              





Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 

    50                  55                  60                  





Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 

65                  70                  75                  80  





Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 

                85                  90                  95      





Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 

            100                 105                 110         





Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 

        115                 120                 125             





Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 

    130                 135                 140                 





Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 

145                 150                 155                 160 





Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 

                165                 170                 175     





Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 

            180                 185                 190         





Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 

        195                 200                 205             





Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 

    210                 215                 220                 





Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 

225                 230                 235                 240 





Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 

                245                 250                 255     





Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Ala Lys Asp Pro Thr 

            260                 265                 270         





Val Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe 

        275                 280                 285             





Lys Ser Gly His Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn 

    290                 295                 300                 





Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly 

305                 310                 315                 320 





Gly Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln 

                325                 330                 335     





Arg Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu 

            340                 345                 350         





Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg 

        355                 360                 365             





Tyr Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr 

    370                 375                 380                 





Ser Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg 

385                 390                 395                 400 





Ile His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 

                405                 410                 415     





Ser Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys 

            420                 425                 430         





Cys Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp 

        435                 440                 445             





Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln 

    450                 455                 460                 





Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 

465                 470                 475                 480 





Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 

                485                 490                 495     





<210>  110

<211>  339

<212>  PRT

<213>  Homo sapiens



<400>  110



Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 

1               5                   10                  15      





Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 

            20                  25                  30          





Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 

        35                  40                  45              





Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 

    50                  55                  60                  





Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 

65                  70                  75                  80  





Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 

                85                  90                  95      





Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 

            100                 105                 110         





Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 

        115                 120                 125             





Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 

    130                 135                 140                 





Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 

145                 150                 155                 160 





Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 

                165                 170                 175     





Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 

            180                 185                 190         





Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 

        195                 200                 205             





Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 

    210                 215                 220                 





Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 

225                 230                 235                 240 





Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 

                245                 250                 255     





Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 

            260                 265                 270         





Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 

        275                 280                 285             





Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 

    290                 295                 300                 





Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 

305                 310                 315                 320 





Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 

                325                 330                 335     





Glu Lys Ile 

            





<210>  111

<211>  503

<212>  PRT

<213>  Homo sapiens



<400>  111



Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 

1               5                   10                  15      





Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 

            20                  25                  30          





Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 

        35                  40                  45              





Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 

    50                  55                  60                  





Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 

65                  70                  75                  80  





Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 

                85                  90                  95      





His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 

            100                 105                 110         





Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 

        115                 120                 125             





Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 

    130                 135                 140                 





Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 

145                 150                 155                 160 





Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 

                165                 170                 175     





Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 

            180                 185                 190         





Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 

        195                 200                 205             





Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 

    210                 215                 220                 





Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 

225                 230                 235                 240 





Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 

                245                 250                 255     





Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 

            260                 265                 270         





Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 

        275                 280                 285             





Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 

    290                 295                 300                 





Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 

305                 310                 315                 320 





Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 

                325                 330                 335     





Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 

            340                 345                 350         





Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 

        355                 360                 365             





Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 

    370                 375                 380                 





Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 

385                 390                 395                 400 





Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 

                405                 410                 415     





Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 

            420                 425                 430         





Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 

        435                 440                 445             





Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 

    450                 455                 460                 





Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 

465                 470                 475                 480 





Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 

                485                 490                 495     





Glu Lys Pro Lys Val Ile Gln 

            500             





<210>  112

<211>  580

<212>  PRT

<213>  Homo sapiens



<400>  112



Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro 

1               5                   10                  15      





Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu 

            20                  25                  30          





Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala 

        35                  40                  45              





Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly 

    50                  55                  60                  





Leu Gly Ser Glu Thr Pro Lys Ser Gln Val Gly Thr Leu Leu Phe Arg 

65                  70                  75                  80  





Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala Ser Glu 

                85                  90                  95      





Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly Leu Cys 

            100                 105                 110         





Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe 

        115                 120                 125             





Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe 

    130                 135                 140                 





Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser 

145                 150                 155                 160 





Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg 

                165                 170                 175     





Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys 

            180                 185                 190         





Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro 

        195                 200                 205             





Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe 

    210                 215                 220                 





Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp 

225                 230                 235                 240 





Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe 

                245                 250                 255     





Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val 

            260                 265                 270         





Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly 

        275                 280                 285             





Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu 

    290                 295                 300                 





Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg 

305                 310                 315                 320 





Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu 

                325                 330                 335     





Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg 

            340                 345                 350         





Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala 

        355                 360                 365             





Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu 

    370                 375                 380                 





Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe 

385                 390                 395                 400 





Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser 

                405                 410                 415     





Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val 

            420                 425                 430         





Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly 

        435                 440                 445             





Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu 

    450                 455                 460                 





Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg 

465                 470                 475                 480 





Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg 

                485                 490                 495     





Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro 

            500                 505                 510         





Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu 

        515                 520                 525             





Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro 

    530                 535                 540                 





Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys 

545                 550                 555                 560 





Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg 

                565                 570                 575     





Leu Gln Asp Gln 

            580 





<210>  113

<211>  317

<212>  PRT

<213>  Homo sapiens



<400>  113



Met Arg Ala Ala Ala Ala Gly Gly Gly Val Arg Thr Ala Ala Leu Ala 

1               5                   10                  15      





Leu Leu Leu Gly Ala Leu His Trp Ala Pro Ala Arg Cys Glu Glu Tyr 

            20                  25                  30          





Asp Tyr Tyr Gly Trp Gln Ala Glu Pro Leu His Gly Arg Ser Tyr Ser 

        35                  40                  45              





Lys Pro Pro Gln Cys Leu Asp Ile Pro Ala Asp Leu Pro Leu Cys His 

    50                  55                  60                  





Thr Val Gly Tyr Lys Arg Met Arg Leu Pro Asn Leu Leu Glu His Glu 

65                  70                  75                  80  





Ser Leu Ala Glu Val Lys Gln Gln Ala Ser Ser Trp Leu Pro Leu Leu 

                85                  90                  95      





Ala Lys Arg Cys His Ser Asp Thr Gln Val Phe Leu Cys Ser Leu Phe 

            100                 105                 110         





Ala Pro Val Cys Leu Asp Arg Pro Ile Tyr Pro Cys Arg Ser Leu Cys 

        115                 120                 125             





Glu Ala Val Arg Ala Gly Cys Ala Pro Leu Met Glu Ala Tyr Gly Phe 

    130                 135                 140                 





Pro Trp Pro Glu Met Leu His Cys His Lys Phe Pro Leu Asp Asn Asp 

145                 150                 155                 160 





Leu Cys Ile Ala Val Gln Phe Gly His Leu Pro Ala Thr Ala Pro Pro 

                165                 170                 175     





Val Thr Lys Ile Cys Ala Gln Cys Glu Met Glu His Ser Ala Asp Gly 

            180                 185                 190         





Leu Met Glu Gln Met Cys Ser Ser Asp Phe Val Val Lys Met Arg Ile 

        195                 200                 205             





Lys Glu Ile Lys Ile Glu Asn Gly Asp Arg Lys Leu Ile Gly Ala Gln 

    210                 215                 220                 





Lys Lys Lys Lys Leu Leu Lys Pro Gly Pro Leu Lys Arg Lys Asp Thr 

225                 230                 235                 240 





Lys Arg Leu Val Leu His Met Lys Asn Gly Ala Gly Cys Pro Cys Pro 

                245                 250                 255     





Gln Leu Asp Ser Leu Ala Gly Ser Phe Leu Val Met Gly Arg Lys Val 

            260                 265                 270         





Asp Gly Gln Leu Leu Leu Met Ala Val Tyr Arg Trp Asp Lys Lys Asn 

        275                 280                 285             





Lys Glu Met Lys Phe Ala Val Lys Phe Met Phe Ser Tyr Pro Cys Ser 

    290                 295                 300                 





Leu Tyr Tyr Pro Phe Phe Tyr Gly Ala Ala Glu Pro His 

305                 310                 315         





<210>  114

<211>  195

<212>  PRT

<213>  Homo sapiens



<400>  114



Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 

1               5                   10                  15      





Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 

            20                  25                  30          





Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 

        35                  40                  45              





Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 

    50                  55                  60                  





Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 

65                  70                  75                  80  





Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 

                85                  90                  95      





Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 

            100                 105                 110         





Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 

        115                 120                 125             





Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 

    130                 135                 140                 





Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 

145                 150                 155                 160 





Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 

                165                 170                 175     





Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys 

            180                 185                 190         





Lys Gly Lys 

        195 





<210>  115

<211>  2549

<212>  PRT

<213>  Homo sapiens



<400>  115



Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 

1               5                   10                  15      





Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 

            20                  25                  30          





Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 

        35                  40                  45              





Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 

    50                  55                  60                  





Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 

65                  70                  75                  80  





Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 

                85                  90                  95      





Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 

            100                 105                 110         





Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 

        115                 120                 125             





Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 

    130                 135                 140                 





Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 

145                 150                 155                 160 





Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 

                165                 170                 175     





Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 

            180                 185                 190         





Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 

        195                 200                 205             





Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 

    210                 215                 220                 





Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 

225                 230                 235                 240 





Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 

                245                 250                 255     





Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 

            260                 265                 270         





Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 

        275                 280                 285             





Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 

    290                 295                 300                 





Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 

305                 310                 315                 320 





Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 

                325                 330                 335     





Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 

            340                 345                 350         





Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 

        355                 360                 365             





Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 

    370                 375                 380                 





Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 

385                 390                 395                 400 





Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 

                405                 410                 415     





Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 

            420                 425                 430         





Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 

        435                 440                 445             





Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 

    450                 455                 460                 





Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 

465                 470                 475                 480 





Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 

                485                 490                 495     





Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 

            500                 505                 510         





Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 

        515                 520                 525             





Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 

    530                 535                 540                 





Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 

545                 550                 555                 560 





Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 

                565                 570                 575     





Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 

            580                 585                 590         





Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 

        595                 600                 605             





His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 

    610                 615                 620                 





Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 

625                 630                 635                 640 





Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 

                645                 650                 655     





Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 

            660                 665                 670         





Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 

        675                 680                 685             





Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 

    690                 695                 700                 





Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 

705                 710                 715                 720 





Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 

                725                 730                 735     





Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 

            740                 745                 750         





Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 

        755                 760                 765             





Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 

    770                 775                 780                 





Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 

785                 790                 795                 800 





Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 

                805                 810                 815     





Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 

            820                 825                 830         





Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 

        835                 840                 845             





Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 

    850                 855                 860                 





Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 

865                 870                 875                 880 





Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 

                885                 890                 895     





Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 

            900                 905                 910         





Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 

        915                 920                 925             





Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 

    930                 935                 940                 





Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 

945                 950                 955                 960 





Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 

                965                 970                 975     





Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 

            980                 985                 990         





Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 

        995                 1000                 1005             





Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 

    1010                 1015                 1020             





Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 

    1025                 1030                 1035             





Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 

    1040                 1045                 1050             





Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 

    1055                 1060                 1065             





Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 

    1070                 1075                 1080             





His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 

    1085                 1090                 1095             





Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 

    1100                 1105                 1110             





Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 

    1115                 1120                 1125             





Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 

    1130                 1135                 1140             





Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 

    1145                 1150                 1155             





Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 

    1160                 1165                 1170             





Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 

    1175                 1180                 1185             





Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 

    1190                 1195                 1200             





Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 

    1205                 1210                 1215             





Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 

    1220                 1225                 1230             





His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 

    1235                 1240                 1245             





Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 

    1250                 1255                 1260             





Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 

    1265                 1270                 1275             





Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 

    1280                 1285                 1290             





Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 

    1295                 1300                 1305             





Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 

    1310                 1315                 1320             





Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 

    1325                 1330                 1335             





Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 

    1340                 1345                 1350             





Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 

    1355                 1360                 1365             





Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 

    1370                 1375                 1380             





Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 

    1385                 1390                 1395             





Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 

    1400                 1405                 1410             





Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 

    1415                 1420                 1425             





Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 

    1430                 1435                 1440             





Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 

    1445                 1450                 1455             





Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 

    1460                 1465                 1470             





Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 

    1475                 1480                 1485             





Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 

    1490                 1495                 1500             





Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 

    1505                 1510                 1515             





Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 

    1520                 1525                 1530             





Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 

    1535                 1540                 1545             





Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 

    1550                 1555                 1560             





Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 

    1565                 1570                 1575             





Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 

    1580                 1585                 1590             





His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 

    1595                 1600                 1605             





Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 

    1610                 1615                 1620             





Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 

    1625                 1630                 1635             





Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 

    1640                 1645                 1650             





Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 

    1655                 1660                 1665             





Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 

    1670                 1675                 1680             





Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 

    1685                 1690                 1695             





Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 

    1700                 1705                 1710             





Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 

    1715                 1720                 1725             





Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 

    1730                 1735                 1740             





His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 

    1745                 1750                 1755             





Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 

    1760                 1765                 1770             





Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 

    1775                 1780                 1785             





Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 

    1790                 1795                 1800             





Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 

    1805                 1810                 1815             





His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 

    1820                 1825                 1830             





Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 

    1835                 1840                 1845             





Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 

    1850                 1855                 1860             





Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 

    1865                 1870                 1875             





Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 

    1880                 1885                 1890             





Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 

    1895                 1900                 1905             





Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 

    1910                 1915                 1920             





Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 

    1925                 1930                 1935             





Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 

    1940                 1945                 1950             





Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 

    1955                 1960                 1965             





Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 

    1970                 1975                 1980             





Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 

    1985                 1990                 1995             





Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 

    2000                 2005                 2010             





Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 

    2015                 2020                 2025             





Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 

    2030                 2035                 2040             





Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 

    2045                 2050                 2055             





Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 

    2060                 2065                 2070             





Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 

    2075                 2080                 2085             





Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 

    2090                 2095                 2100             





Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 

    2105                 2110                 2115             





Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 

    2120                 2125                 2130             





Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 

    2135                 2140                 2145             





Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 

    2150                 2155                 2160             





Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 

    2165                 2170                 2175             





Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 

    2180                 2185                 2190             





Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 

    2195                 2200                 2205             





Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 

    2210                 2215                 2220             





Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 

    2225                 2230                 2235             





Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 

    2240                 2245                 2250             





Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 

    2255                 2260                 2265             





Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 

    2270                 2275                 2280             





Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 

    2285                 2290                 2295             





Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 

    2300                 2305                 2310             





Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 

    2315                 2320                 2325             





Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 

    2330                 2335                 2340             





Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 

    2345                 2350                 2355             





Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 

    2360                 2365                 2370             





Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 

    2375                 2380                 2385             





Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 

    2390                 2395                 2400             





Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 

    2405                 2410                 2415             





Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 

    2420                 2425                 2430             





Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 

    2435                 2440                 2445             





Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 

    2450                 2455                 2460             





Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 

    2465                 2470                 2475             





Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 

    2480                 2485                 2490             





Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 

    2495                 2500                 2505             





Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 

    2510                 2515                 2520             





Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 

    2525                 2530                 2535             





Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 

    2540                 2545                 





<210>  116

<211>  650

<212>  PRT

<213>  Homo sapiens



<400>  116



Met Ala Ser Asn Met Asp Arg Glu Met Ile Leu Ala Asp Phe Gln Ala 

1               5                   10                  15      





Cys Thr Gly Ile Glu Asn Ile Asp Glu Ala Ile Thr Leu Leu Glu Gln 

            20                  25                  30          





Asn Asn Trp Asp Leu Val Ala Ala Ile Asn Gly Val Ile Pro Gln Glu 

        35                  40                  45              





Asn Gly Ile Leu Gln Ser Glu Tyr Gly Gly Glu Thr Ile Pro Gly Pro 

    50                  55                  60                  





Ala Phe Asn Pro Ala Ser His Pro Ala Ser Ala Pro Thr Ser Ser Ser 

65                  70                  75                  80  





Ser Ser Ala Phe Arg Pro Val Met Pro Ser Arg Gln Ile Val Glu Arg 

                85                  90                  95      





Gln Pro Arg Met Leu Asp Phe Arg Val Glu Tyr Arg Asp Arg Asn Val 

            100                 105                 110         





Asp Val Val Leu Glu Asp Thr Cys Thr Val Gly Glu Ile Lys Gln Ile 

        115                 120                 125             





Leu Glu Asn Glu Leu Gln Ile Pro Val Ser Lys Met Leu Leu Lys Gly 

    130                 135                 140                 





Trp Lys Thr Gly Asp Val Glu Asp Ser Thr Val Leu Lys Ser Leu His 

145                 150                 155                 160 





Leu Pro Lys Asn Asn Ser Leu Tyr Val Leu Thr Pro Asp Leu Pro Pro 

                165                 170                 175     





Pro Ser Ser Ser Ser His Ala Gly Ala Leu Gln Glu Ser Leu Asn Gln 

            180                 185                 190         





Asn Phe Met Leu Ile Ile Thr His Arg Glu Val Gln Arg Glu Tyr Asn 

        195                 200                 205             





Leu Asn Phe Ser Gly Ser Ser Thr Ile Gln Glu Val Lys Arg Asn Val 

    210                 215                 220                 





Tyr Asp Leu Thr Ser Ile Pro Val Arg His Gln Leu Trp Glu Gly Trp 

225                 230                 235                 240 





Pro Thr Ser Ala Thr Asp Asp Ser Met Cys Leu Ala Glu Ser Gly Leu 

                245                 250                 255     





Ser Tyr Pro Cys His Arg Leu Thr Val Gly Arg Arg Ser Ser Pro Ala 

            260                 265                 270         





Gln Thr Arg Glu Gln Ser Glu Glu Gln Ile Thr Asp Val His Met Val 

        275                 280                 285             





Ser Asp Ser Asp Gly Asp Asp Phe Glu Asp Ala Thr Glu Phe Gly Val 

    290                 295                 300                 





Asp Asp Gly Glu Val Phe Gly Met Ala Ser Ser Ala Leu Arg Lys Ser 

305                 310                 315                 320 





Pro Met Met Pro Glu Asn Ala Glu Asn Glu Gly Asp Ala Leu Leu Gln 

                325                 330                 335     





Phe Thr Ala Glu Phe Ser Ser Arg Tyr Gly Asp Cys His Pro Val Phe 

            340                 345                 350         





Phe Ile Gly Ser Leu Glu Ala Ala Phe Gln Glu Ala Phe Tyr Val Lys 

        355                 360                 365             





Ala Arg Asp Arg Lys Leu Leu Ala Ile Tyr Leu His His Asp Glu Ser 

    370                 375                 380                 





Val Leu Thr Asn Val Phe Cys Ser Gln Met Leu Cys Ala Glu Ser Ile 

385                 390                 395                 400 





Val Ser Tyr Leu Ser Gln Asn Phe Ile Thr Trp Ala Trp Asp Leu Thr 

                405                 410                 415     





Lys Asp Ser Asn Arg Ala Arg Phe Leu Thr Met Cys Asn Arg His Phe 

            420                 425                 430         





Gly Ser Val Val Ala Gln Thr Ile Arg Thr Gln Lys Thr Asp Gln Phe 

        435                 440                 445             





Pro Leu Phe Leu Ile Ile Met Gly Lys Arg Ser Ser Asn Glu Val Leu 

    450                 455                 460                 





Asn Val Ile Gln Gly Asn Thr Thr Val Asp Glu Leu Met Met Arg Leu 

465                 470                 475                 480 





Met Ala Ala Met Glu Ile Phe Thr Ala Gln Gln Gln Glu Asp Ile Lys 

                485                 490                 495     





Asp Glu Asp Glu Arg Glu Ala Arg Glu Asn Val Lys Arg Glu Gln Asp 

            500                 505                 510         





Glu Ala Tyr Arg Leu Ser Leu Glu Ala Asp Arg Ala Lys Arg Glu Ala 

        515                 520                 525             





His Glu Arg Glu Met Ala Glu Gln Phe Arg Leu Glu Gln Ile Arg Lys 

    530                 535                 540                 





Glu Gln Glu Glu Glu Arg Glu Ala Ile Arg Leu Ser Leu Glu Gln Ala 

545                 550                 555                 560 





Leu Pro Pro Glu Pro Lys Glu Glu Asn Ala Glu Pro Val Ser Lys Leu 

                565                 570                 575     





Arg Ile Arg Thr Pro Ser Gly Glu Phe Leu Glu Arg Arg Phe Leu Ala 

            580                 585                 590         





Ser Asn Lys Leu Gln Ile Val Phe Asp Phe Val Ala Ser Lys Gly Phe 

        595                 600                 605             





Pro Trp Asp Glu Tyr Lys Leu Leu Ser Thr Phe Pro Arg Arg Asp Val 

    610                 615                 620                 





Thr Gln Leu Asp Pro Asn Lys Ser Leu Leu Glu Val Lys Leu Phe Pro 

625                 630                 635                 640 





Gln Glu Thr Leu Phe Leu Glu Ala Lys Glu 

                645                 650 





<210>  117

<211>  796

<212>  PRT

<213>  Homo sapiens



<400>  117



Met Ala Glu Thr Lys Asp Val Phe Gly Gln Glu Pro His Pro Val Glu 

1               5                   10                  15      





Asp Asp Leu Tyr Lys Glu Arg Thr Arg Lys Arg Arg Lys Ser Asp Arg 

            20                  25                  30          





Asp Gln Arg Phe Arg Ala Phe Pro Ser Met Glu Gln Ser Ala Leu Lys 

        35                  40                  45              





Glu Tyr Glu Lys Leu Glu Ser Arg Thr Arg Arg Val Leu Ser Asn Thr 

    50                  55                  60                  





Tyr Gln Lys Leu Ile Gln Ser Val Phe Leu Asp Asp Ser Ile Pro Asn 

65                  70                  75                  80  





Gly Val Lys Tyr Leu Ile Asn Arg Leu Leu Ala Leu Ile Glu Lys Pro 

                85                  90                  95      





Thr Val Asp Pro Ile Tyr Ile Ala Leu Phe Gly Ser Thr Gly Ala Gly 

            100                 105                 110         





Lys Ser Ser Leu Ile Asn Ala Ile Ile Gln Gln Ala Met Phe Leu Pro 

        115                 120                 125             





Val Ser Gly Glu Ser Ile Cys Thr Ser Cys Ile Val Gln Val Ser Ser 

    130                 135                 140                 





Gly Cys Cys Val Gln Tyr Glu Ala Lys Ile His Leu Leu Ser Asp Gln 

145                 150                 155                 160 





Glu Trp Arg Glu Glu Leu Lys Asn Leu Thr Lys Leu Leu His Arg Thr 

                165                 170                 175     





Glu Glu Leu Ser Arg Glu Glu Ala Asp Ala Trp Asn Arg Asp Glu Ala 

            180                 185                 190         





Val Glu Glu Ala Thr Trp Lys Leu Gln Met Ile Tyr Gly Asn Gly Ala 

        195                 200                 205             





Glu Ser Lys Asn Tyr Glu Glu Leu Leu Arg Ala Lys Pro Lys Arg Lys 

    210                 215                 220                 





Ile Pro Thr Ser Arg Val Ile Thr Leu Lys Ala Glu Glu Ala Glu Glu 

225                 230                 235                 240 





Leu Ser Ile Lys Leu Asp Pro Tyr Ile Arg Thr Gln Arg Arg Asp Trp 

                245                 250                 255     





Asp Gly Glu Ala Ala Glu Met Arg Ile Trp Pro Leu Ile Lys His Val 

            260                 265                 270         





Glu Val Thr Leu Pro Lys Ser Asp Leu Ile Pro Glu Gly Val Val Leu 

        275                 280                 285             





Val Asp Ile Pro Gly Thr Gly Asp Phe Asn Ser Lys Arg Asp Glu Met 

    290                 295                 300                 





Trp Lys Lys Thr Ile Asp Lys Cys Ser Val Ile Trp Val Ile Ser Asp 

305                 310                 315                 320 





Ile Glu Arg Val Ser Gly Gly Gln Ala His Glu Asp Leu Leu Asn Glu 

                325                 330                 335     





Ser Ile Lys Ala Cys Gln Arg Gly Phe Cys Arg Asp Val Ala Leu Val 

            340                 345                 350         





Val Thr Lys Met Asp Lys Leu His Leu Pro Glu Tyr Leu Arg Glu Arg 

        355                 360                 365             





Lys Ala Gly Asn Gln Ala Ile Gln Ser Gln Arg Glu Ala Val Leu Glu 

    370                 375                 380                 





Arg Asn Glu Met Ile Lys Leu Gln Arg Thr Arg Ile Leu Lys Glu Lys 

385                 390                 395                 400 





Leu Lys Arg Lys Leu Pro Ala Asp Phe Lys Val Leu Glu Ala Ser Asp 

                405                 410                 415     





Leu Val Tyr Thr Val Ser Ala Gln Glu Tyr Trp Gln Gln Ala Leu Leu 

            420                 425                 430         





Thr Glu Glu Glu Thr Glu Ile Pro Lys Leu Arg Glu Tyr Ile Arg Lys 

        435                 440                 445             





Ser Leu Leu Asp Lys Lys Lys Arg Thr Val Thr Lys Tyr Val Thr Glu 

    450                 455                 460                 





Ala Phe Gly Leu Leu Leu Leu Thr Asp Ser Phe Asn Ser Thr Gln Asn 

465                 470                 475                 480 





Leu Pro Asn Glu His Leu His Met Ser Val Leu Arg Arg Phe Ala Glu 

                485                 490                 495     





Glu Lys Val Glu Leu Leu Glu Lys Ala Ile Ala Gln Cys Phe Ala Cys 

            500                 505                 510         





Met Glu Gln Pro Leu Gln Glu Gly Val Arg Thr Ala Arg Thr Ser Tyr 

        515                 520                 525             





Arg Cys Ile Leu Arg Ala Cys Leu Val Arg Ser Lys Gly Asn Gln Gly 

    530                 535                 540                 





Phe His Gln Thr Leu Lys Ala Val Cys Leu Lys Asn Gly Ile Tyr Ala 

545                 550                 555                 560 





Ser Arg Thr Leu Ala Arg Ile Asp Leu Asn Glu Ala Leu Thr Gln Pro 

                565                 570                 575     





Val Tyr Asp Gln Ile Asp Pro Val Phe Gly Ser Ile Phe Arg Thr Gly 

            580                 585                 590         





Lys Pro Thr Gly Ser Ala Leu Met Pro His Ile Asp Ala Phe Lys Gln 

        595                 600                 605             





Ser Leu Gln Glu Lys Met Thr Glu Ile Gly Ile Arg Ser Gly Trp Lys 

    610                 615                 620                 





Tyr Asp Ser Cys Lys Lys Asn Phe Leu Ile Gln Glu Ile Ser Ala Ile 

625                 630                 635                 640 





Leu Gly Gly Leu Glu Asp His Ile Leu Arg Arg Lys Arg Arg Ile Tyr 

                645                 650                 655     





Glu Ser Leu Thr Ala Ser Val Gln Ser Asp Leu Lys Leu Cys Tyr Glu 

            660                 665                 670         





Glu Ala Ala Gln Ile Thr Gly Lys Lys Ala Cys Glu Arg Met Lys Asp 

        675                 680                 685             





Ala Ile Arg Arg Gly Val Asp Arg Gln Val Ala Glu Gly Met Phe Glu 

    690                 695                 700                 





Arg Ala Gln Glu Arg Met Gln His Gln Phe Gln Gln Leu Lys Thr Gly 

705                 710                 715                 720 





Ile Val Glu Lys Val Lys Gly Ser Ile Thr Thr Met Leu Ala Leu Ala 

                725                 730                 735     





Ser Ser Gln Gly Asp Gly Leu Tyr Lys Glu Leu Ala Asp Val Gly Ser 

            740                 745                 750         





Glu Tyr Lys Glu Met Glu Lys Leu His Arg Ser Leu Arg Glu Val Ala 

        755                 760                 765             





Glu Asn Ala Arg Leu Arg Lys Gly Met Gln Glu Phe Leu Leu Arg Ala 

    770                 775                 780                 





Ser Pro Ser Lys Ala Gly Pro Pro Gly Thr Ser Leu 

785                 790                 795     





<210>  118

<211>  256

<212>  PRT

<213>  Homo sapiens



<400>  118



Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala 

1               5                   10                  15      





Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His 

            20                  25                  30          





Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg 

        35                  40                  45              





Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser 

    50                  55                  60                  





Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu 

65                  70                  75                  80  





Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr 

                85                  90                  95      





Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala 

            100                 105                 110         





Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala 

        115                 120                 125             





Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln 

    130                 135                 140                 





Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val 

145                 150                 155                 160 





Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr 

                165                 170                 175     





Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro 

            180                 185                 190         





Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile 

        195                 200                 205             





Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys 

    210                 215                 220                 





Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val 

225                 230                 235                 240 





Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro 

                245                 250                 255     





<210>  119

<211>  890

<212>  PRT

<213>  Homo sapiens



<400>  119



Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 

1               5                   10                  15      





Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 

            20                  25                  30          





Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 

        35                  40                  45              





Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 

    50                  55                  60                  





Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 

65                  70                  75                  80  





Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 

                85                  90                  95      





His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 

            100                 105                 110         





Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 

        115                 120                 125             





Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 

    130                 135                 140                 





Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 

145                 150                 155                 160 





Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 

                165                 170                 175     





Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 

            180                 185                 190         





Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 

        195                 200                 205             





Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 

    210                 215                 220                 





Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 

225                 230                 235                 240 





Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 

                245                 250                 255     





Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 

            260                 265                 270         





Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 

        275                 280                 285             





Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 

    290                 295                 300                 





Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 

305                 310                 315                 320 





Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 

                325                 330                 335     





Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 

            340                 345                 350         





Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 

        355                 360                 365             





Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 

    370                 375                 380                 





Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 

385                 390                 395                 400 





Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 

                405                 410                 415     





Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 

            420                 425                 430         





Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 

        435                 440                 445             





Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 

    450                 455                 460                 





Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 

465                 470                 475                 480 





Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 

                485                 490                 495     





Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 

            500                 505                 510         





Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 

        515                 520                 525             





Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 

    530                 535                 540                 





Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 

545                 550                 555                 560 





Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 

                565                 570                 575     





His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 

            580                 585                 590         





Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 

        595                 600                 605             





Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 

    610                 615                 620                 





Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 

625                 630                 635                 640 





Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 

                645                 650                 655     





Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 

            660                 665                 670         





Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 

        675                 680                 685             





Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 

    690                 695                 700                 





Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 

705                 710                 715                 720 





Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 

                725                 730                 735     





Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 

            740                 745                 750         





Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 

        755                 760                 765             





Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 

    770                 775                 780                 





Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 

785                 790                 795                 800 





Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 

                805                 810                 815     





Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 

            820                 825                 830         





Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 

        835                 840                 845             





Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 

    850                 855                 860                 





His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 

865                 870                 875                 880 





Gln Gln Gly Leu Leu Pro His Ser Ser Cys 

                885                 890 





<210>  120

<211>  784

<212>  PRT

<213>  Homo sapiens



<400>  120



Met Gln Arg Leu Met Met Leu Leu Ala Thr Ser Gly Ala Cys Leu Gly 

1               5                   10                  15      





Leu Leu Ala Val Ala Ala Val Ala Ala Ala Gly Ala Asn Pro Ala Gln 

            20                  25                  30          





Arg Asp Thr His Ser Leu Leu Pro Thr His Arg Arg Gln Lys Arg Asp 

        35                  40                  45              





Trp Ile Trp Asn Gln Met His Ile Asp Glu Glu Lys Asn Thr Ser Leu 

    50                  55                  60                  





Pro His His Val Gly Lys Ile Lys Ser Ser Val Ser Arg Lys Asn Ala 

65                  70                  75                  80  





Lys Tyr Leu Leu Lys Gly Glu Tyr Val Gly Lys Val Phe Arg Val Asp 

                85                  90                  95      





Ala Glu Thr Gly Asp Val Phe Ala Ile Glu Arg Leu Asp Arg Glu Asn 

            100                 105                 110         





Ile Ser Glu Tyr His Leu Thr Ala Val Ile Val Asp Lys Asp Thr Gly 

        115                 120                 125             





Glu Asn Leu Glu Thr Pro Ser Ser Phe Thr Ile Lys Val His Asp Val 

    130                 135                 140                 





Asn Asp Asn Trp Pro Val Phe Thr His Arg Leu Phe Asn Ala Ser Val 

145                 150                 155                 160 





Pro Glu Ser Ser Ala Val Gly Thr Ser Val Ile Ser Val Thr Ala Val 

                165                 170                 175     





Asp Ala Asp Asp Pro Thr Val Gly Asp His Ala Ser Val Met Tyr Gln 

            180                 185                 190         





Ile Leu Lys Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile 

        195                 200                 205             





Ile Thr Ile Thr Lys Ser Leu Asp Arg Glu Lys Gln Ala Arg Tyr Glu 

    210                 215                 220                 





Ile Val Val Glu Ala Arg Asp Ala Gln Gly Leu Arg Gly Asp Ser Gly 

225                 230                 235                 240 





Thr Ala Thr Val Leu Val Thr Leu Gln Asp Ile Asn Asp Asn Phe Pro 

                245                 250                 255     





Phe Phe Thr Gln Thr Lys Tyr Thr Phe Val Val Pro Glu Asp Thr Arg 

            260                 265                 270         





Val Gly Thr Ser Val Gly Ser Leu Phe Val Glu Asp Pro Asp Glu Pro 

        275                 280                 285             





Gln Asn Arg Met Thr Lys Tyr Ser Ile Leu Arg Gly Asp Tyr Gln Asp 

    290                 295                 300                 





Ala Phe Thr Ile Glu Thr Asn Pro Ala His Asn Glu Gly Ile Ile Lys 

305                 310                 315                 320 





Pro Met Lys Pro Leu Asp Tyr Glu Tyr Ile Gln Gln Tyr Ser Phe Ile 

                325                 330                 335     





Val Glu Ala Thr Asp Pro Thr Ile Asp Leu Arg Tyr Met Ser Pro Pro 

            340                 345                 350         





Ala Gly Asn Arg Ala Gln Val Ile Ile Asn Ile Thr Asp Val Asp Glu 

        355                 360                 365             





Pro Pro Ile Phe Gln Gln Pro Phe Tyr His Phe Gln Leu Lys Glu Asn 

    370                 375                 380                 





Gln Lys Lys Pro Leu Ile Gly Thr Val Leu Ala Met Asp Pro Asp Ala 

385                 390                 395                 400 





Ala Arg His Ser Ile Gly Tyr Ser Ile Arg Arg Thr Ser Asp Lys Gly 

                405                 410                 415     





Gln Phe Phe Arg Val Thr Lys Lys Gly Asp Ile Tyr Asn Glu Lys Glu 

            420                 425                 430         





Leu Asp Arg Glu Val Tyr Pro Trp Tyr Asn Leu Thr Val Glu Ala Lys 

        435                 440                 445             





Glu Leu Asp Ser Thr Gly Thr Pro Thr Gly Lys Glu Ser Ile Val Gln 

    450                 455                 460                 





Val His Ile Glu Val Leu Asp Glu Asn Asp Asn Ala Pro Glu Phe Ala 

465                 470                 475                 480 





Lys Pro Tyr Gln Pro Lys Val Cys Glu Asn Ala Val His Gly Gln Leu 

                485                 490                 495     





Val Leu Gln Ile Ser Ala Ile Asp Lys Asp Ile Thr Pro Arg Asn Val 

            500                 505                 510         





Lys Phe Lys Phe Ile Leu Asn Thr Glu Asn Asn Phe Thr Leu Thr Asp 

        515                 520                 525             





Asn His Asp Asn Thr Ala Asn Ile Thr Val Lys Tyr Gly Gln Phe Asp 

    530                 535                 540                 





Arg Glu His Thr Lys Val His Phe Leu Pro Val Val Ile Ser Asp Asn 

545                 550                 555                 560 





Gly Met Pro Ser Arg Thr Gly Thr Ser Thr Leu Thr Val Ala Val Cys 

                565                 570                 575     





Lys Cys Asn Glu Gln Gly Glu Phe Thr Phe Cys Glu Asp Met Ala Ala 

            580                 585                 590         





Gln Val Gly Val Ser Ile Gln Ala Val Val Ala Ile Leu Leu Cys Ile 

        595                 600                 605             





Leu Thr Ile Thr Val Ile Thr Leu Leu Ile Phe Leu Arg Arg Arg Leu 

    610                 615                 620                 





Arg Lys Gln Ala Arg Ala His Gly Lys Ser Val Pro Glu Ile His Glu 

625                 630                 635                 640 





Gln Leu Val Thr Tyr Asp Glu Glu Gly Gly Gly Glu Met Asp Thr Thr 

                645                 650                 655     





Ser Tyr Asp Val Ser Val Leu Asn Ser Val Arg Arg Gly Gly Ala Lys 

            660                 665                 670         





Pro Pro Arg Pro Ala Leu Asp Ala Arg Pro Ser Leu Tyr Ala Gln Val 

        675                 680                 685             





Gln Lys Pro Pro Arg His Ala Pro Gly Ala His Gly Gly Pro Gly Glu 

    690                 695                 700                 





Met Ala Ala Met Ile Glu Val Lys Lys Asp Glu Ala Asp His Asp Gly 

705                 710                 715                 720 





Asp Gly Pro Pro Tyr Asp Thr Leu His Ile Tyr Gly Tyr Glu Gly Ser 

                725                 730                 735     





Glu Ser Ile Ala Glu Ser Leu Ser Ser Leu Gly Thr Asp Ser Ser Asp 

            740                 745                 750         





Ser Asp Val Asp Tyr Asp Phe Leu Asn Asp Trp Gly Pro Arg Phe Lys 

        755                 760                 765             





Met Leu Ala Glu Leu Tyr Gly Ser Asp Pro Arg Glu Glu Leu Leu Tyr 

    770                 775                 780                 





<210>  121

<211>  92

<212>  PRT

<213>  Homo sapiens



<400>  121



Met Thr Lys Leu Glu Glu His Leu Glu Gly Ile Val Asn Ile Phe His 

1               5                   10                  15      





Gln Tyr Ser Val Arg Lys Gly His Phe Asp Thr Leu Ser Lys Gly Glu 

            20                  25                  30          





Leu Lys Gln Leu Leu Thr Lys Glu Leu Ala Asn Thr Ile Lys Asn Ile 

        35                  40                  45              





Lys Asp Lys Ala Val Ile Asp Glu Ile Phe Gln Gly Leu Asp Ala Asn 

    50                  55                  60                  





Gln Asp Glu Gln Val Asp Phe Gln Glu Phe Ile Ser Leu Val Ala Ile 

65                  70                  75                  80  





Ala Leu Lys Ala Ala His Tyr His Thr His Lys Glu 

                85                  90          





<210>  122

<211>  529

<212>  PRT

<213>  Homo sapiens



<400>  122



Met Ala Pro Ala Arg Thr Met Ala Arg Ala Arg Leu Ala Pro Ala Gly 

1               5                   10                  15      





Ile Pro Ala Val Ala Leu Trp Leu Leu Cys Thr Leu Gly Leu Gln Gly 

            20                  25                  30          





Thr Gln Ala Gly Pro Pro Pro Ala Pro Pro Gly Leu Pro Ala Gly Ala 

        35                  40                  45              





Asp Cys Leu Asn Ser Phe Thr Ala Gly Val Pro Gly Phe Val Leu Asp 

    50                  55                  60                  





Thr Asn Ala Ser Val Ser Asn Gly Ala Thr Phe Leu Glu Ser Pro Thr 

65                  70                  75                  80  





Val Arg Arg Gly Trp Asp Cys Val Arg Ala Cys Cys Thr Thr Gln Asn 

                85                  90                  95      





Cys Asn Leu Ala Leu Val Glu Leu Gln Pro Asp Arg Gly Glu Asp Ala 

            100                 105                 110         





Ile Ala Ala Cys Phe Leu Ile Asn Cys Leu Tyr Glu Gln Asn Phe Val 

        115                 120                 125             





Cys Lys Phe Ala Pro Arg Glu Gly Phe Ile Asn Tyr Leu Thr Arg Glu 

    130                 135                 140                 





Val Tyr Arg Ser Tyr Arg Gln Leu Arg Thr Gln Gly Phe Gly Gly Ser 

145                 150                 155                 160 





Gly Ile Pro Lys Ala Trp Ala Gly Ile Asp Leu Lys Val Gln Pro Gln 

                165                 170                 175     





Glu Pro Leu Val Leu Lys Asp Val Glu Asn Thr Asp Trp Arg Leu Leu 

            180                 185                 190         





Arg Gly Asp Thr Asp Val Arg Val Glu Arg Lys Asp Pro Asn Gln Val 

        195                 200                 205             





Glu Leu Trp Gly Leu Lys Glu Gly Thr Tyr Leu Phe Gln Leu Thr Val 

    210                 215                 220                 





Thr Ser Ser Asp His Pro Glu Asp Thr Ala Asn Val Thr Val Thr Val 

225                 230                 235                 240 





Leu Ser Thr Lys Gln Thr Glu Asp Tyr Cys Leu Ala Ser Asn Lys Val 

                245                 250                 255     





Gly Arg Cys Arg Gly Ser Phe Pro Arg Trp Tyr Tyr Asp Pro Thr Glu 

            260                 265                 270         





Gln Ile Cys Lys Ser Phe Val Tyr Gly Gly Cys Leu Gly Asn Lys Asn 

        275                 280                 285             





Asn Tyr Leu Arg Glu Glu Glu Cys Ile Leu Ala Cys Arg Gly Val Gln 

    290                 295                 300                 





Gly Gly Pro Leu Arg Gly Ser Ser Gly Ala Gln Ala Thr Phe Pro Gln 

305                 310                 315                 320 





Gly Pro Ser Met Glu Arg Arg His Pro Val Cys Ser Gly Thr Cys Gln 

                325                 330                 335     





Pro Thr Gln Phe Arg Cys Ser Asn Gly Cys Cys Ile Asp Ser Phe Leu 

            340                 345                 350         





Glu Cys Asp Asp Thr Pro Asn Cys Pro Asp Ala Ser Asp Glu Ala Ala 

        355                 360                 365             





Cys Glu Lys Tyr Thr Ser Gly Phe Asp Glu Leu Gln Arg Ile His Phe 

    370                 375                 380                 





Pro Ser Asp Lys Gly His Cys Val Asp Leu Pro Asp Thr Gly Leu Cys 

385                 390                 395                 400 





Lys Glu Ser Ile Pro Arg Trp Tyr Tyr Asn Pro Phe Ser Glu His Cys 

                405                 410                 415     





Ala Arg Phe Thr Tyr Gly Gly Cys Tyr Gly Asn Lys Asn Asn Phe Glu 

            420                 425                 430         





Glu Glu Gln Gln Cys Leu Glu Ser Cys Arg Gly Ile Ser Lys Lys Asp 

        435                 440                 445             





Val Phe Gly Leu Arg Arg Glu Ile Pro Ile Pro Ser Thr Gly Ser Val 

    450                 455                 460                 





Glu Met Ala Val Ala Val Phe Leu Val Ile Cys Ile Val Val Val Val 

465                 470                 475                 480 





Ala Ile Leu Gly Tyr Cys Phe Phe Lys Asn Gln Arg Lys Asp Phe His 

                485                 490                 495     





Gly His His His His Pro Pro Pro Thr Pro Ala Ser Ser Thr Val Ser 

            500                 505                 510         





Thr Thr Glu Asp Thr Glu His Leu Val Tyr Asn His Thr Thr Arg Pro 

        515                 520                 525             





Leu 

    





<210>  123

<211>  92

<212>  PRT

<213>  Homo sapiens



<400>  123



Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 

1               5                   10                  15      





Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 

            20                  25                  30          





Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 

        35                  40                  45              





Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 

    50                  55                  60                  





Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 

65                  70                  75                  80  





Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 

                85                  90          





<210>  124

<211>  882

<212>  PRT

<213>  Homo sapiens



<400>  124



Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 

1               5                   10                  15      





Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 

            20                  25                  30          





Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 

        35                  40                  45              





Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 

    50                  55                  60                  





Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 

65                  70                  75                  80  





Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 

                85                  90                  95      





His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 

            100                 105                 110         





Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 

        115                 120                 125             





Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 

    130                 135                 140                 





Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 

145                 150                 155                 160 





Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 

                165                 170                 175     





Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 

            180                 185                 190         





Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 

        195                 200                 205             





Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 

    210                 215                 220                 





Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 

225                 230                 235                 240 





Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 

                245                 250                 255     





Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 

            260                 265                 270         





Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 

        275                 280                 285             





Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 

    290                 295                 300                 





Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 

305                 310                 315                 320 





Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 

                325                 330                 335     





Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 

            340                 345                 350         





Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 

        355                 360                 365             





Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 

    370                 375                 380                 





Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 

385                 390                 395                 400 





Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 

                405                 410                 415     





Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 

            420                 425                 430         





Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 

        435                 440                 445             





Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 

    450                 455                 460                 





Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 

465                 470                 475                 480 





Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 

                485                 490                 495     





Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 

            500                 505                 510         





Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 

        515                 520                 525             





Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 

    530                 535                 540                 





Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 

545                 550                 555                 560 





Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 

                565                 570                 575     





Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 

            580                 585                 590         





Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 

        595                 600                 605             





Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 

    610                 615                 620                 





Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 

625                 630                 635                 640 





Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 

                645                 650                 655     





Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 

            660                 665                 670         





Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 

        675                 680                 685             





Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 

    690                 695                 700                 





Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 

705                 710                 715                 720 





Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 

                725                 730                 735     





Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 

            740                 745                 750         





Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 

        755                 760                 765             





Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 

    770                 775                 780                 





Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 

785                 790                 795                 800 





Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 

                805                 810                 815     





Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 

            820                 825                 830         





Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 

        835                 840                 845             





Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 

    850                 855                 860                 





Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 

865                 870                 875                 880 





Asp Asp 

        





<210>  125

<211>  323

<212>  PRT

<213>  Homo sapiens



<400>  125



Met Ala Tyr Val Pro Ala Pro Gly Tyr Gln Pro Thr Tyr Asn Pro Thr 

1               5                   10                  15      





Leu Pro Tyr Tyr Gln Pro Ile Pro Gly Gly Leu Asn Val Gly Met Ser 

            20                  25                  30          





Val Tyr Ile Gln Gly Val Ala Ser Glu His Met Lys Arg Phe Phe Val 

        35                  40                  45              





Asn Phe Val Val Gly Gln Asp Pro Gly Ser Asp Val Ala Phe His Phe 

    50                  55                  60                  





Asn Pro Arg Phe Asp Gly Trp Asp Lys Val Val Phe Asn Thr Leu Gln 

65                  70                  75                  80  





Gly Gly Lys Trp Gly Ser Glu Glu Arg Lys Arg Ser Met Pro Phe Lys 

                85                  90                  95      





Lys Gly Ala Ala Phe Glu Leu Val Phe Ile Val Leu Ala Glu His Tyr 

            100                 105                 110         





Lys Val Val Val Asn Gly Asn Pro Phe Tyr Glu Tyr Gly His Arg Leu 

        115                 120                 125             





Pro Leu Gln Met Val Thr His Leu Gln Val Asp Gly Asp Leu Gln Leu 

    130                 135                 140                 





Gln Ser Ile Asn Phe Ile Gly Gly Gln Pro Leu Arg Pro Gln Gly Pro 

145                 150                 155                 160 





Pro Met Met Pro Pro Tyr Pro Gly Pro Gly His Cys His Gln Gln Leu 

                165                 170                 175     





Asn Ser Leu Pro Thr Met Glu Gly Pro Pro Thr Phe Asn Pro Pro Val 

            180                 185                 190         





Pro Tyr Phe Gly Arg Leu Gln Gly Gly Leu Thr Ala Arg Arg Thr Ile 

        195                 200                 205             





Ile Ile Lys Gly Tyr Val Pro Pro Thr Gly Lys Ser Phe Ala Ile Asn 

    210                 215                 220                 





Phe Lys Val Gly Ser Ser Gly Asp Ile Ala Leu His Ile Asn Pro Arg 

225                 230                 235                 240 





Met Gly Asn Gly Thr Val Val Arg Asn Ser Leu Leu Asn Gly Ser Trp 

                245                 250                 255     





Gly Ser Glu Glu Lys Lys Ile Thr His Asn Pro Phe Gly Pro Gly Gln 

            260                 265                 270         





Phe Phe Asp Leu Ser Ile Arg Cys Gly Leu Asp Arg Phe Lys Val Tyr 

        275                 280                 285             





Ala Asn Gly Gln His Leu Phe Asp Phe Ala His Arg Leu Ser Ala Phe 

    290                 295                 300                 





Gln Arg Val Asp Thr Leu Glu Ile Gln Gly Asp Val Thr Leu Ser Tyr 

305                 310                 315                 320 





Val Gln Ile 

            





<210>  126

<211>  263

<212>  PRT

<213>  Homo sapiens



<400>  126



Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 

1               5                   10                  15      





Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 

            20                  25                  30          





Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 

        35                  40                  45              





Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 

    50                  55                  60                  





Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 

65                  70                  75                  80  





Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 

                85                  90                  95      





Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 

            100                 105                 110         





Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 

        115                 120                 125             





Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 

    130                 135                 140                 





Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 

145                 150                 155                 160 





Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 

                165                 170                 175     





Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 

            180                 185                 190         





Val Val Glu His Ile Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp Thr 

        195                 200                 205             





Pro Gly Leu Ser Pro Met Gln Thr Leu Lys Val Ser Val Ser Ala Val 

    210                 215                 220                 





Thr Leu Gly Leu Gly Leu Ile Ile Phe Ser Leu Gly Val Ile Ser Trp 

225                 230                 235                 240 





Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser Asn Tyr 

                245                 250                 255     





Ser Glu Gly Trp His Ile Ser 

            260             





<210>  127

<211>  163

<212>  PRT

<213>  Homo sapiens



<400>  127



Met Arg Arg Leu Leu Ile Pro Leu Ala Leu Trp Leu Gly Ala Val Gly 

1               5                   10                  15      





Val Gly Val Ala Glu Leu Thr Glu Ala Gln Arg Arg Gly Leu Gln Val 

            20                  25                  30          





Ala Leu Glu Glu Phe His Lys His Pro Pro Val Gln Trp Ala Phe Gln 

        35                  40                  45              





Glu Thr Ser Val Glu Ser Ala Val Asp Thr Pro Phe Pro Ala Gly Ile 

    50                  55                  60                  





Phe Val Arg Leu Glu Phe Lys Leu Gln Gln Thr Ser Cys Arg Lys Arg 

65                  70                  75                  80  





Asp Trp Lys Lys Pro Glu Cys Lys Val Arg Pro Asn Gly Arg Lys Arg 

                85                  90                  95      





Lys Cys Leu Ala Cys Ile Lys Leu Gly Ser Glu Asp Lys Val Leu Gly 

            100                 105                 110         





Arg Leu Val His Cys Pro Ile Glu Thr Gln Val Leu Arg Glu Ala Glu 

        115                 120                 125             





Glu His Gln Glu Thr Gln Cys Leu Arg Val Gln Arg Ala Gly Glu Asp 

    130                 135                 140                 





Pro His Ser Phe Tyr Phe Pro Gly Gln Phe Ala Phe Ser Lys Ala Leu 

145                 150                 155                 160 





Pro Arg Ser 

            





<210>  128

<211>  602

<212>  PRT

<213>  Homo sapiens



<400>  128



Met Pro Tyr Lys Leu Lys Lys Glu Lys Glu Pro Pro Lys Val Ala Lys 

1               5                   10                  15      





Cys Thr Ala Lys Pro Ser Ser Ser Gly Lys Asp Gly Gly Gly Glu Asn 

            20                  25                  30          





Thr Glu Glu Ala Gln Pro Gln Pro Gln Pro Gln Pro Gln Pro Gln Ala 

        35                  40                  45              





Gln Ser Gln Pro Pro Ser Ser Asn Lys Arg Pro Ser Asn Ser Thr Pro 

    50                  55                  60                  





Pro Pro Thr Gln Leu Ser Lys Ile Lys Tyr Ser Gly Gly Pro Gln Ile 

65                  70                  75                  80  





Val Lys Lys Glu Arg Arg Gln Ser Ser Ser Arg Phe Asn Leu Ser Lys 

                85                  90                  95      





Asn Arg Glu Leu Gln Lys Leu Pro Ala Leu Lys Asp Ser Pro Thr Gln 

            100                 105                 110         





Glu Arg Glu Glu Leu Phe Ile Gln Lys Leu Arg Gln Cys Cys Val Leu 

        115                 120                 125             





Phe Asp Phe Val Ser Asp Pro Leu Ser Asp Leu Lys Phe Lys Glu Val 

    130                 135                 140                 





Lys Arg Ala Gly Leu Asn Glu Met Val Glu Tyr Ile Thr His Ser Arg 

145                 150                 155                 160 





Asp Val Val Thr Glu Ala Ile Tyr Pro Glu Ala Val Thr Met Phe Ser 

                165                 170                 175     





Val Asn Leu Phe Arg Thr Leu Pro Pro Ser Ser Asn Pro Thr Gly Ala 

            180                 185                 190         





Glu Phe Asp Pro Glu Glu Asp Glu Pro Thr Leu Glu Ala Ala Trp Pro 

        195                 200                 205             





His Leu Gln Leu Val Tyr Glu Phe Phe Leu Arg Phe Leu Glu Ser Pro 

    210                 215                 220                 





Asp Phe Gln Pro Asn Ile Ala Lys Lys Tyr Ile Asp Gln Lys Phe Val 

225                 230                 235                 240 





Leu Ala Leu Leu Asp Leu Phe Asp Ser Glu Asp Pro Arg Glu Arg Asp 

                245                 250                 255     





Phe Leu Lys Thr Ile Leu His Arg Ile Tyr Gly Lys Phe Leu Gly Leu 

            260                 265                 270         





Arg Ala Tyr Ile Arg Arg Gln Ile Asn His Ile Phe Tyr Arg Phe Ile 

        275                 280                 285             





Tyr Glu Thr Glu His His Asn Gly Ile Ala Glu Leu Leu Glu Ile Leu 

    290                 295                 300                 





Gly Ser Ile Ile Asn Gly Phe Ala Leu Pro Leu Lys Glu Glu His Lys 

305                 310                 315                 320 





Met Phe Leu Ile Arg Val Leu Leu Pro Leu His Lys Val Lys Ser Leu 

                325                 330                 335     





Ser Val Tyr His Pro Gln Leu Ala Tyr Cys Val Val Gln Phe Leu Glu 

            340                 345                 350         





Lys Glu Ser Ser Leu Thr Glu Pro Val Ile Val Gly Leu Leu Lys Phe 

        355                 360                 365             





Trp Pro Lys Thr His Ser Pro Lys Glu Val Met Phe Leu Asn Glu Leu 

    370                 375                 380                 





Glu Glu Ile Leu Asp Val Ile Glu Pro Ser Glu Phe Ser Lys Val Met 

385                 390                 395                 400 





Glu Pro Leu Phe Arg Gln Leu Ala Lys Cys Val Ser Ser Pro His Phe 

                405                 410                 415     





Gln Val Ala Glu Arg Ala Leu Tyr Tyr Trp Asn Asn Glu Tyr Ile Met 

            420                 425                 430         





Ser Leu Ile Ser Asp Asn Ala Ala Arg Val Leu Pro Ile Met Phe Pro 

        435                 440                 445             





Ala Leu Tyr Arg Asn Ser Lys Ser His Trp Asn Lys Thr Ile His Gly 

    450                 455                 460                 





Leu Ile Tyr Asn Ala Leu Lys Leu Phe Met Glu Met Asn Gln Lys Leu 

465                 470                 475                 480 





Phe Asp Asp Cys Thr Gln Gln Tyr Lys Ala Glu Lys Gln Lys Gly Arg 

                485                 490                 495     





Phe Arg Met Lys Glu Arg Glu Glu Met Trp Gln Lys Ile Glu Glu Leu 

            500                 505                 510         





Ala Arg Leu Asn Pro Gln Tyr Pro Met Phe Arg Ala Pro Pro Pro Leu 

        515                 520                 525             





Pro Pro Val Tyr Ser Met Glu Thr Glu Thr Pro Thr Ala Glu Asp Ile 

    530                 535                 540                 





Gln Leu Leu Lys Arg Thr Val Glu Thr Glu Ala Val Gln Met Leu Lys 

545                 550                 555                 560 





Asp Ile Lys Lys Glu Lys Val Leu Leu Arg Arg Lys Ser Glu Leu Pro 

                565                 570                 575     





Gln Asp Val Tyr Thr Ile Lys Ala Leu Glu Ala His Lys Arg Ala Glu 

            580                 585                 590         





Glu Phe Leu Thr Ala Ser Gln Glu Ala Leu 

        595                 600         





<210>  129

<211>  263

<212>  PRT

<213>  Homo sapiens



<400>  129



Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 

1               5                   10                  15      





Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 

            20                  25                  30          





Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 

        35                  40                  45              





Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 

    50                  55                  60                  





Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 

65                  70                  75                  80  





Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 

                85                  90                  95      





Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 

            100                 105                 110         





Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 

        115                 120                 125             





Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 

    130                 135                 140                 





Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 

145                 150                 155                 160 





Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 

                165                 170                 175     





Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 

            180                 185                 190         





Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 

        195                 200                 205             





Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 

    210                 215                 220                 





Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 

225                 230                 235                 240 





Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 

                245                 250                 255     





Glu Arg Cys Val Glu Ile Pro 

            260             





<210>  130

<211>  208

<212>  PRT

<213>  Homo sapiens



<400>  130



Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 

1               5                   10                  15      





Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 

            20                  25                  30          





Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 

        35                  40                  45              





Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 

    50                  55                  60                  





Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 

65                  70                  75                  80  





Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 

                85                  90                  95      





Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 

            100                 105                 110         





Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 

        115                 120                 125             





Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 

    130                 135                 140                 





Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 

145                 150                 155                 160 





Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 

                165                 170                 175     





Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 

            180                 185                 190         





Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 

        195                 200                 205             





<210>  131

<211>  164

<212>  PRT

<213>  Homo sapiens



<400>  131



Met Ser Glu Pro Ala Gly Asp Val Arg Gln Asn Pro Cys Gly Ser Lys 

1               5                   10                  15      





Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Ser Arg 

            20                  25                  30          





Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln Glu Ala Arg Glu Arg 

        35                  40                  45              





Trp Asn Phe Asp Phe Val Thr Glu Thr Pro Leu Glu Gly Asp Phe Ala 

    50                  55                  60                  





Trp Glu Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu Pro Thr 

65                  70                  75                  80  





Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg Pro Gly 

                85                  90                  95      





Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu Glu Asp His Val Asp 

            100                 105                 110         





Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser Gly Glu Gln Ala Glu 

        115                 120                 125             





Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly Arg Lys Arg Arg Gln 

    130                 135                 140                 





Thr Ser Met Thr Asp Phe Tyr His Ser Lys Arg Arg Leu Ile Phe Ser 

145                 150                 155                 160 





Lys Arg Lys Pro 

                





<210>  132

<211>  79

<212>  PRT

<213>  Homo sapiens



<400>  132



Met Lys Val Thr Gly Ile Phe Leu Leu Ser Ala Leu Ala Leu Leu Ser 

1               5                   10                  15      





Leu Ser Gly Asn Thr Gly Ala Asp Ser Leu Gly Arg Glu Ala Lys Cys 

            20                  25                  30          





Tyr Asn Glu Leu Asn Gly Cys Thr Lys Ile Tyr Asp Pro Val Cys Gly 

        35                  40                  45              





Thr Asp Gly Asn Thr Tyr Pro Asn Glu Cys Val Leu Cys Phe Glu Asn 

    50                  55                  60                  





Arg Lys Arg Gln Thr Ser Ile Leu Ile Gln Lys Ser Gly Pro Cys 

65                  70                  75                  





<210>  133

<211>  707

<212>  PRT

<213>  Homo sapiens



<400>  133



Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys 

1               5                   10                  15      





Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro 

            20                  25                  30          





Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr 

        35                  40                  45              





Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser 

    50                  55                  60                  





Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu 

65                  70                  75                  80  





Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr 

                85                  90                  95      





Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly 

            100                 105                 110         





Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr 

        115                 120                 125             





Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala 

    130                 135                 140                 





Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr 

145                 150                 155                 160 





Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly 

                165                 170                 175     





Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe 

            180                 185                 190         





Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu 

        195                 200                 205             





Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn 

    210                 215                 220                 





Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser 

225                 230                 235                 240 





Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys 

                245                 250                 255     





Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro 

            260                 265                 270         





Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys 

        275                 280                 285             





Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr 

    290                 295                 300                 





Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr 

305                 310                 315                 320 





Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr 

                325                 330                 335     





Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr 

            340                 345                 350         





Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp 

        355                 360                 365             





Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys 

    370                 375                 380                 





Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala 

385                 390                 395                 400 





His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu 

                405                 410                 415     





Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His 

            420                 425                 430         





Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu 

        435                 440                 445             





Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro 

    450                 455                 460                 





Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg 

465                 470                 475                 480 





Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro 

                485                 490                 495     





Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val 

            500                 505                 510         





Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly 

        515                 520                 525             





Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu 

    530                 535                 540                 





Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp 

545                 550                 555                 560 





Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser 

                565                 570                 575     





Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly 

            580                 585                 590         





Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala 

        595                 600                 605             





Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met 

    610                 615                 620                 





Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln 

625                 630                 635                 640 





Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly 

                645                 650                 655     





Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr 

            660                 665                 670         





Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu 

        675                 680                 685             





Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys 

    690                 695                 700                 





Pro Glu Asp 

705         





<210>  134

<211>  303

<212>  PRT

<213>  Homo sapiens



<400>  134



Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 

1               5                   10                  15      





Ala Ala Pro Gln Gln Glu Ala Leu Pro Asp Glu Thr Glu Val Val Glu 

            20                  25                  30          





Glu Thr Val Ala Glu Val Thr Glu Val Ser Val Gly Ala Asn Pro Val 

        35                  40                  45              





Gln Val Glu Val Gly Glu Phe Asp Asp Gly Ala Glu Glu Thr Glu Glu 

    50                  55                  60                  





Glu Val Val Ala Glu Asn Pro Cys Gln Asn His His Cys Lys His Gly 

65                  70                  75                  80  





Lys Val Cys Glu Leu Asp Glu Asn Asn Thr Pro Met Cys Val Cys Gln 

                85                  90                  95      





Asp Pro Thr Ser Cys Pro Ala Pro Ile Gly Glu Phe Glu Lys Val Cys 

            100                 105                 110         





Ser Asn Asp Asn Lys Thr Phe Asp Ser Ser Cys His Phe Phe Ala Thr 

        115                 120                 125             





Lys Cys Thr Leu Glu Gly Thr Lys Lys Gly His Lys Leu His Leu Asp 

    130                 135                 140                 





Tyr Ile Gly Pro Cys Lys Tyr Ile Pro Pro Cys Leu Asp Ser Glu Leu 

145                 150                 155                 160 





Thr Glu Phe Pro Leu Arg Met Arg Asp Trp Leu Lys Asn Val Leu Val 

                165                 170                 175     





Thr Leu Tyr Glu Arg Asp Glu Asp Asn Asn Leu Leu Thr Glu Lys Gln 

            180                 185                 190         





Lys Leu Arg Val Lys Lys Ile His Glu Asn Glu Lys Arg Leu Glu Ala 

        195                 200                 205             





Gly Asp His Pro Val Glu Leu Leu Ala Arg Asp Phe Glu Lys Asn Tyr 

    210                 215                 220                 





Asn Met Tyr Ile Phe Pro Val His Trp Gln Phe Gly Gln Leu Asp Gln 

225                 230                 235                 240 





His Pro Ile Asp Gly Tyr Leu Ser His Thr Glu Leu Ala Pro Leu Arg 

                245                 250                 255     





Ala Pro Leu Ile Pro Met Glu His Cys Thr Thr Arg Phe Phe Glu Thr 

            260                 265                 270         





Cys Asp Leu Asp Asn Asp Lys Tyr Ile Ala Leu Asp Glu Trp Ala Gly 

        275                 280                 285             





Cys Phe Gly Ile Lys Gln Lys Asp Ile Asp Lys Asp Leu Val Ile 

    290                 295                 300             





<210>  135

<211>  388

<212>  PRT

<213>  Homo sapiens



<400>  135



Met Lys Trp Met Val Val Val Leu Val Cys Leu Gln Leu Leu Glu Ala 

1               5                   10                  15      





Ala Val Val Lys Val Pro Leu Lys Lys Phe Lys Ser Ile Arg Glu Thr 

            20                  25                  30          





Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg Thr His Lys Tyr 

        35                  40                  45              





Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser Val Thr Tyr Glu 

    50                  55                  60                  





Pro Met Ala Tyr Met Asp Ala Ala Tyr Phe Gly Glu Ile Ser Ile Gly 

65                  70                  75                  80  





Thr Pro Pro Gln Asn Phe Leu Val Leu Phe Asp Thr Gly Ser Ser Asn 

                85                  90                  95      





Leu Trp Val Pro Ser Val Tyr Cys Gln Ser Gln Ala Cys Thr Ser His 

            100                 105                 110         





Ser Arg Phe Asn Pro Ser Glu Ser Ser Thr Tyr Ser Thr Asn Gly Gln 

        115                 120                 125             





Thr Phe Ser Leu Gln Tyr Gly Ser Gly Ser Leu Thr Gly Phe Phe Gly 

    130                 135                 140                 





Tyr Asp Thr Leu Thr Val Gln Ser Ile Gln Val Pro Asn Gln Glu Phe 

145                 150                 155                 160 





Gly Leu Ser Glu Asn Glu Pro Gly Thr Asn Phe Val Tyr Ala Gln Phe 

                165                 170                 175     





Asp Gly Ile Met Gly Leu Ala Tyr Pro Ala Leu Ser Val Asp Glu Ala 

            180                 185                 190         





Thr Thr Ala Met Gln Gly Met Val Gln Glu Gly Ala Leu Thr Ser Pro 

        195                 200                 205             





Val Phe Ser Val Tyr Leu Ser Asn Gln Gln Gly Ser Ser Gly Gly Ala 

    210                 215                 220                 





Val Val Phe Gly Gly Val Asp Ser Ser Leu Tyr Thr Gly Gln Ile Tyr 

225                 230                 235                 240 





Trp Ala Pro Val Thr Gln Glu Leu Tyr Trp Gln Ile Gly Ile Glu Glu 

                245                 250                 255     





Phe Leu Ile Gly Gly Gln Ala Ser Gly Trp Cys Ser Glu Gly Cys Gln 

            260                 265                 270         





Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Val Pro Gln Gln Tyr 

        275                 280                 285             





Met Ser Ala Leu Leu Gln Ala Thr Gly Ala Gln Glu Asp Glu Tyr Gly 

    290                 295                 300                 





Gln Phe Leu Val Asn Cys Asn Ser Ile Gln Asn Leu Pro Ser Leu Thr 

305                 310                 315                 320 





Phe Ile Ile Asn Gly Val Glu Phe Pro Leu Pro Pro Ser Ser Tyr Ile 

                325                 330                 335     





Leu Ser Asn Asn Gly Tyr Cys Thr Val Gly Val Glu Pro Thr Tyr Leu 

            340                 345                 350         





Ser Ser Gln Asn Gly Gln Pro Leu Trp Ile Leu Gly Asp Val Phe Leu 

        355                 360                 365             





Arg Ser Tyr Tyr Ser Val Tyr Asp Leu Gly Asn Asn Arg Val Gly Phe 

    370                 375                 380                 





Ala Thr Ala Ala 

385             





<210>  136

<211>  460

<212>  PRT

<213>  Homo sapiens



<400>  136



Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 

1               5                   10                  15      





Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 

            20                  25                  30          





Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 

        35                  40                  45              





Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 

    50                  55                  60                  





Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 

65                  70                  75                  80  





Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 

                85                  90                  95      





Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 

            100                 105                 110         





Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 

        115                 120                 125             





Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 

    130                 135                 140                 





Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 

145                 150                 155                 160 





Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 

                165                 170                 175     





Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 

            180                 185                 190         





His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 

        195                 200                 205             





Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 

    210                 215                 220                 





Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 

225                 230                 235                 240 





Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 

                245                 250                 255     





Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 

            260                 265                 270         





Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 

        275                 280                 285             





Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 

    290                 295                 300                 





Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 

305                 310                 315                 320 





Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 

                325                 330                 335     





Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 

            340                 345                 350         





Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 

        355                 360                 365             





Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 

    370                 375                 380                 





Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 

385                 390                 395                 400 





Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 

                405                 410                 415     





Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 

            420                 425                 430         





Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 

        435                 440                 445             





Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 

    450                 455                 460 





<210>  137

<211>  259

<212>  PRT

<213>  Homo sapiens



<400>  137



Met Ser Glu Val Pro Val Ala Arg Val Trp Leu Val Leu Leu Leu Leu 

1               5                   10                  15      





Thr Val Gln Val Gly Val Thr Ala Gly Ala Pro Trp Gln Cys Ala Pro 

            20                  25                  30          





Cys Ser Ala Glu Lys Leu Ala Leu Cys Pro Pro Val Ser Ala Ser Cys 

        35                  40                  45              





Ser Glu Val Thr Arg Ser Ala Gly Cys Gly Cys Cys Pro Met Cys Ala 

    50                  55                  60                  





Leu Pro Leu Gly Ala Ala Cys Gly Val Ala Thr Ala Arg Cys Ala Arg 

65                  70                  75                  80  





Gly Leu Ser Cys Arg Ala Leu Pro Gly Glu Gln Gln Pro Leu His Ala 

                85                  90                  95      





Leu Thr Arg Gly Gln Gly Ala Cys Val Gln Glu Ser Asp Ala Ser Ala 

            100                 105                 110         





Pro His Ala Ala Glu Ala Gly Ser Pro Glu Ser Pro Glu Ser Thr Glu 

        115                 120                 125             





Ile Thr Glu Glu Glu Leu Leu Asp Asn Phe His Leu Met Ala Pro Ser 

    130                 135                 140                 





Glu Glu Asp His Ser Ile Leu Trp Asp Ala Ile Ser Thr Tyr Asp Gly 

145                 150                 155                 160 





Ser Lys Ala Leu His Val Thr Asn Ile Lys Lys Trp Lys Glu Pro Cys 

                165                 170                 175     





Arg Ile Glu Leu Tyr Arg Val Val Glu Ser Leu Ala Lys Ala Gln Glu 

            180                 185                 190         





Thr Ser Gly Glu Glu Ile Ser Lys Phe Tyr Leu Pro Asn Cys Asn Lys 

        195                 200                 205             





Asn Gly Phe Tyr His Ser Arg Gln Cys Glu Thr Ser Met Asp Gly Glu 

    210                 215                 220                 





Ala Gly Leu Cys Trp Cys Val Tyr Pro Trp Asn Gly Lys Arg Ile Pro 

225                 230                 235                 240 





Gly Ser Pro Glu Ile Arg Gly Asp Pro Asn Cys Gln Ile Tyr Phe Asn 

                245                 250                 255     





Val Gln Asn 

            





<210>  138

<211>  171

<212>  PRT

<213>  Homo sapiens



<400>  138



Met Leu Val Asn Phe Ile Leu Arg Cys Gly Leu Leu Leu Val Thr Leu 

1               5                   10                  15      





Ser Leu Ala Ile Ala Lys His Lys Gln Ser Ser Phe Thr Lys Ser Cys 

            20                  25                  30          





Tyr Pro Arg Gly Thr Leu Ser Gln Ala Val Asp Ala Leu Tyr Ile Lys 

        35                  40                  45              





Ala Ala Trp Leu Lys Ala Thr Ile Pro Glu Asp Arg Ile Lys Asn Ile 

    50                  55                  60                  





Arg Leu Leu Lys Lys Lys Thr Lys Lys Gln Phe Met Lys Asn Cys Gln 

65                  70                  75                  80  





Phe Gln Glu Gln Leu Leu Ser Phe Phe Met Glu Asp Val Phe Gly Gln 

                85                  90                  95      





Leu Gln Leu Gln Gly Cys Lys Lys Ile Arg Phe Val Glu Asp Phe His 

            100                 105                 110         





Ser Leu Arg Gln Lys Leu Ser His Cys Ile Ser Cys Ala Ser Ser Ala 

        115                 120                 125             





Arg Glu Met Lys Ser Ile Thr Arg Met Lys Arg Ile Phe Tyr Arg Ile 

    130                 135                 140                 





Gly Asn Lys Gly Ile Tyr Lys Ala Ile Ser Glu Leu Asp Ile Leu Leu 

145                 150                 155                 160 





Ser Trp Ile Lys Lys Leu Leu Glu Ser Ser Gln 

                165                 170     





<210>  139

<211>  385

<212>  PRT

<213>  Homo sapiens



<400>  139



Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly Thr 

1               5                   10                  15      





His Gly Ala Ser Gly Ala Ala Gly Phe Val Gln Ala Pro Leu Ser Gln 

            20                  25                  30          





Gln Arg Trp Val Gly Gly Ser Val Glu Leu His Cys Glu Ala Val Gly 

        35                  40                  45              





Ser Pro Val Pro Glu Ile Gln Trp Trp Phe Glu Gly Gln Gly Pro Asn 

    50                  55                  60                  





Asp Thr Cys Ser Gln Leu Trp Asp Gly Ala Arg Leu Asp Arg Val His 

65                  70                  75                  80  





Ile His Ala Thr Tyr His Gln His Ala Ala Ser Thr Ile Ser Ile Asp 

                85                  90                  95      





Thr Leu Val Glu Glu Asp Thr Gly Thr Tyr Glu Cys Arg Ala Ser Asn 

            100                 105                 110         





Asp Pro Asp Arg Asn His Leu Thr Arg Ala Pro Arg Val Lys Trp Val 

        115                 120                 125             





Arg Ala Gln Ala Val Val Leu Val Leu Glu Pro Gly Thr Val Phe Thr 

    130                 135                 140                 





Thr Val Glu Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn 

145                 150                 155                 160 





Asp Ser Ala Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val 

                165                 170                 175     





Val Leu Lys Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val 

            180                 185                 190         





Asp Ser Asp Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu 

        195                 200                 205             





Pro Met Gly Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys 

    210                 215                 220                 





Ala Val Lys Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu 

225                 230                 235                 240 





Val Cys Lys Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr 

                245                 250                 255     





Lys Ile Thr Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser 

            260                 265                 270         





Arg Phe Phe Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu 

        275                 280                 285             





Asn Leu Asn Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr 

    290                 295                 300                 





Ser Ser Lys Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser 

305                 310                 315                 320 





His Leu Ala Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu 

                325                 330                 335     





Val Leu Val Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu 

            340                 345                 350         





Asp Val Leu Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ser Ser 

        355                 360                 365             





Gly Gln His Gln Asn Asp Lys Gly Lys Asn Val Arg Gln Arg Asn Ser 

    370                 375                 380                 





Ser 

385 





<210>  140

<211>  1042

<212>  PRT

<213>  Homo sapiens



<400>  140



Met Lys Gln Ser Pro Ala Leu Ala Pro Glu Glu Arg Cys Arg Arg Ala 

1               5                   10                  15      





Gly Ser Pro Lys Pro Val Leu Arg Ala Asp Asp Asn Asn Met Gly Asn 

            20                  25                  30          





Gly Cys Ser Gln Lys Leu Ala Thr Ala Asn Leu Leu Arg Phe Leu Leu 

        35                  40                  45              





Leu Val Leu Ile Pro Cys Ile Cys Ala Leu Val Leu Leu Leu Val Ile 

    50                  55                  60                  





Leu Leu Ser Tyr Val Gly Thr Leu Gln Lys Val Tyr Phe Lys Ser Asn 

65                  70                  75                  80  





Gly Ser Glu Pro Leu Val Thr Asp Gly Glu Ile Gln Gly Ser Asp Val 

                85                  90                  95      





Ile Leu Thr Asn Thr Ile Tyr Asn Gln Ser Thr Val Val Ser Thr Ala 

            100                 105                 110         





His Pro Asp Gln His Val Pro Ala Trp Thr Thr Asp Ala Ser Leu Pro 

        115                 120                 125             





Gly Asp Gln Ser His Arg Asn Thr Ser Ala Cys Met Asn Ile Thr His 

    130                 135                 140                 





Ser Gln Cys Gln Met Leu Pro Tyr His Ala Thr Leu Thr Pro Leu Leu 

145                 150                 155                 160 





Ser Val Val Arg Asn Met Glu Met Glu Lys Phe Leu Lys Phe Phe Thr 

                165                 170                 175     





Tyr Leu His Arg Leu Ser Cys Tyr Gln His Ile Met Leu Phe Gly Cys 

            180                 185                 190         





Thr Leu Ala Phe Pro Glu Cys Ile Ile Asp Gly Asp Asp Ser His Gly 

        195                 200                 205             





Leu Leu Pro Cys Arg Ser Phe Cys Glu Ala Ala Lys Glu Gly Cys Glu 

    210                 215                 220                 





Ser Val Leu Gly Met Val Asn Tyr Ser Trp Pro Asp Phe Leu Arg Cys 

225                 230                 235                 240 





Ser Gln Phe Arg Asn Gln Thr Glu Ser Ser Asn Val Ser Arg Ile Cys 

                245                 250                 255     





Phe Ser Pro Gln Gln Glu Asn Gly Lys Gln Leu Leu Cys Gly Arg Gly 

            260                 265                 270         





Glu Asn Phe Leu Cys Ala Ser Gly Ile Cys Ile Pro Gly Lys Leu Gln 

        275                 280                 285             





Cys Asn Gly Tyr Asn Asp Cys Asp Asp Trp Ser Asp Glu Ala His Cys 

    290                 295                 300                 





Asn Cys Ser Glu Asn Leu Phe His Cys His Thr Gly Lys Cys Leu Asn 

305                 310                 315                 320 





Tyr Ser Leu Val Cys Asp Gly Tyr Asp Asp Cys Gly Asp Leu Ser Asp 

                325                 330                 335     





Glu Gln Asn Cys Asp Cys Asn Pro Thr Thr Glu His Arg Cys Gly Asp 

            340                 345                 350         





Gly Arg Cys Ile Ala Met Glu Trp Val Cys Asp Gly Asp His Asp Cys 

        355                 360                 365             





Val Asp Lys Ser Asp Glu Val Asn Cys Ser Cys His Ser Gln Gly Leu 

    370                 375                 380                 





Val Glu Cys Arg Asn Gly Gln Cys Ile Pro Ser Thr Phe Gln Cys Asp 

385                 390                 395                 400 





Gly Asp Glu Asp Cys Lys Asp Gly Ser Asp Glu Glu Asn Cys Ser Val 

                405                 410                 415     





Ile Gln Thr Ser Cys Gln Glu Gly Asp Gln Arg Cys Leu Tyr Asn Pro 

            420                 425                 430         





Cys Leu Asp Ser Cys Gly Gly Ser Ser Leu Cys Asp Pro Asn Asn Ser 

        435                 440                 445             





Leu Asn Asn Cys Ser Gln Cys Glu Pro Ile Thr Leu Glu Leu Cys Met 

    450                 455                 460                 





Asn Leu Pro Tyr Asn Ser Thr Ser Tyr Pro Asn Tyr Phe Gly His Arg 

465                 470                 475                 480 





Thr Gln Lys Glu Ala Ser Ile Ser Trp Glu Ser Ser Leu Phe Pro Ala 

                485                 490                 495     





Leu Val Gln Thr Asn Cys Tyr Lys Tyr Leu Met Phe Phe Ser Cys Thr 

            500                 505                 510         





Ile Leu Val Pro Lys Cys Asp Val Asn Thr Gly Glu His Ile Pro Pro 

        515                 520                 525             





Cys Arg Ala Leu Cys Glu His Ser Lys Glu Arg Cys Glu Ser Val Leu 

    530                 535                 540                 





Gly Ile Val Gly Leu Gln Trp Pro Glu Asp Thr Asp Cys Ser Gln Phe 

545                 550                 555                 560 





Pro Glu Glu Asn Ser Asp Asn Gln Thr Cys Leu Met Pro Asp Glu Tyr 

                565                 570                 575     





Val Glu Glu Cys Ser Pro Ser His Phe Lys Cys Arg Ser Gly Gln Cys 

            580                 585                 590         





Val Leu Ala Ser Arg Arg Cys Asp Gly Gln Ala Asp Cys Asp Asp Asp 

        595                 600                 605             





Ser Asp Glu Glu Asn Cys Gly Cys Lys Glu Arg Asp Leu Trp Glu Cys 

    610                 615                 620                 





Pro Ser Asn Lys Gln Cys Leu Lys His Thr Val Ile Cys Asp Gly Phe 

625                 630                 635                 640 





Pro Asp Cys Pro Asp Tyr Met Asp Glu Lys Asn Cys Ser Phe Cys Gln 

                645                 650                 655     





Asp Asp Glu Leu Glu Cys Ala Asn His Ala Cys Val Ser Arg Asp Leu 

            660                 665                 670         





Trp Cys Asp Gly Glu Ala Asp Cys Ser Asp Ser Ser Asp Glu Trp Asp 

        675                 680                 685             





Cys Val Thr Leu Ser Ile Asn Val Asn Ser Ser Ser Phe Leu Met Val 

    690                 695                 700                 





His Arg Ala Ala Thr Glu His His Val Cys Ala Asp Gly Trp Gln Glu 

705                 710                 715                 720 





Ile Leu Ser Gln Leu Ala Cys Lys Gln Met Gly Leu Gly Glu Pro Ser 

                725                 730                 735     





Val Thr Lys Leu Ile Gln Glu Gln Glu Lys Glu Pro Arg Trp Leu Thr 

            740                 745                 750         





Leu His Ser Asn Trp Glu Ser Leu Asn Gly Thr Thr Leu His Glu Leu 

        755                 760                 765             





Leu Val Asn Gly Gln Ser Cys Glu Ser Arg Ser Lys Ile Ser Leu Leu 

    770                 775                 780                 





Cys Thr Lys Gln Asp Cys Gly Arg Arg Pro Ala Ala Arg Met Asn Lys 

785                 790                 795                 800 





Arg Ile Leu Gly Gly Arg Thr Ser Arg Pro Gly Arg Trp Pro Trp Gln 

                805                 810                 815     





Cys Ser Leu Gln Ser Glu Pro Ser Gly His Ile Cys Gly Cys Val Leu 

            820                 825                 830         





Ile Ala Lys Lys Trp Val Leu Thr Val Ala His Cys Phe Glu Gly Arg 

        835                 840                 845             





Glu Asn Ala Ala Val Trp Lys Val Val Leu Gly Ile Asn Asn Leu Asp 

    850                 855                 860                 





His Pro Ser Val Phe Met Gln Thr Arg Phe Val Lys Thr Ile Ile Leu 

865                 870                 875                 880 





His Pro Arg Tyr Ser Arg Ala Val Val Asp Tyr Asp Ile Ser Ile Val 

                885                 890                 895     





Glu Leu Ser Glu Asp Ile Ser Glu Thr Gly Tyr Val Arg Pro Val Cys 

            900                 905                 910         





Leu Pro Asn Pro Glu Gln Trp Leu Glu Pro Asp Thr Tyr Cys Tyr Ile 

        915                 920                 925             





Thr Gly Trp Gly His Met Gly Asn Lys Met Pro Phe Lys Leu Gln Glu 

    930                 935                 940                 





Gly Glu Val Arg Ile Ile Ser Leu Glu His Cys Gln Ser Tyr Phe Asp 

945                 950                 955                 960 





Met Lys Thr Ile Thr Thr Arg Met Ile Cys Ala Gly Tyr Glu Ser Gly 

                965                 970                 975     





Thr Val Asp Ser Cys Met Gly Asp Ser Gly Gly Pro Leu Val Cys Glu 

            980                 985                 990         





Lys Pro Gly Gly Arg Trp Thr Leu  Phe Gly Leu Thr Ser  Trp Gly Ser 

        995                 1000                 1005             





Val Cys  Phe Ser Lys Val Leu  Gly Pro Gly Val Tyr  Ser Asn Val 

    1010                 1015                 1020             





Ser Tyr  Phe Val Glu Trp Ile  Lys Arg Gln Ile Tyr  Ile Gln Thr 

    1025                 1030                 1035             





Phe Leu  Leu Asn 

    1040         





<210>  141

<211>  122

<212>  PRT

<213>  Homo sapiens



<400>  141



Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 

1               5                   10                  15      





Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 

            20                  25                  30          





Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Met Ala Ala Val Pro 

        35                  40                  45              





Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser 

    50                  55                  60                  





Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly 

65                  70                  75                  80  





Gly Val Ala Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala 

                85                  90                  95      





Thr Gly Leu Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser 

            100                 105                 110         





Ala Ile Ala Ala Val Ile Ala Arg Phe Tyr 

        115                 120         





<210>  142

<211>  132

<212>  PRT

<213>  Homo sapiens



<400>  142



Met Ala Phe Asp Ser Thr Trp Lys Val Asp Arg Ser Glu Asn Tyr Asp 

1               5                   10                  15      





Lys Phe Met Glu Lys Met Gly Val Asn Ile Val Lys Arg Lys Leu Ala 

            20                  25                  30          





Ala His Asp Asn Leu Lys Leu Thr Ile Thr Gln Glu Gly Asn Lys Phe 

        35                  40                  45              





Thr Val Lys Glu Ser Ser Ala Phe Arg Asn Ile Glu Val Val Phe Glu 

    50                  55                  60                  





Leu Gly Val Thr Phe Asn Tyr Asn Leu Ala Asp Gly Thr Glu Leu Arg 

65                  70                  75                  80  





Gly Thr Trp Ser Leu Glu Gly Asn Lys Leu Ile Gly Lys Phe Lys Arg 

                85                  90                  95      





Thr Asp Asn Gly Asn Glu Leu Asn Thr Val Arg Glu Ile Ile Gly Asp 

            100                 105                 110         





Glu Leu Val Gln Thr Tyr Val Tyr Glu Gly Val Glu Ala Lys Arg Ile 

        115                 120                 125             





Phe Lys Lys Asp 

    130         





<210>  143

<211>  325

<212>  PRT

<213>  Homo sapiens



<400>  143



Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro 

1               5                   10                  15      





Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly 

            20                  25                  30          





Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu 

        35                  40                  45              





Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val 

    50                  55                  60                  





Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg 

65                  70                  75                  80  





Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu 

                85                  90                  95      





Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr 

            100                 105                 110         





Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu 

        115                 120                 125             





Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu 

    130                 135                 140                 





Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu 

145                 150                 155                 160 





Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala 

                165                 170                 175     





Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg 

            180                 185                 190         





Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His 

        195                 200                 205             





His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg 

    210                 215                 220                 





Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr 

225                 230                 235                 240 





Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu 

                245                 250                 255     





His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys 

            260                 265                 270         





Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro 

        275                 280                 285             





Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro 

    290                 295                 300                 





Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His 

305                 310                 315                 320 





Thr Gln Arg Met Gln 

                325 





<210>  144

<211>  352

<212>  PRT

<213>  Homo sapiens



<400>  144



Met Arg Ser Leu Gly Ala Leu Leu Leu Leu Leu Ser Ala Cys Leu Ala 

1               5                   10                  15      





Val Ser Ala Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln 

            20                  25                  30          





Glu Asn Phe Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala 

        35                  40                  45              





Ile Gly Ser Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr 

    50                  55                  60                  





Val Ser Thr Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser 

65                  70                  75                  80  





Met Thr Ser Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly 

                85                  90                  95      





Ala Tyr Glu Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser 

            100                 105                 110         





Lys Trp Asn Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp 

        115                 120                 125             





Glu Tyr Ala Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro 

    130                 135                 140                 





Thr Ile Thr Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr 

145                 150                 155                 160 





Leu Leu Gln Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu 

                165                 170                 175     





Asp Ser Ile Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu 

            180                 185                 190         





Gln Glu Pro Glu Pro Ile Leu Ile Pro Arg Val Arg Arg Ala Val Leu 

        195                 200                 205             





Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val Thr Glu Val 

    210                 215                 220                 





Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala Gly Pro Cys 

225                 230                 235                 240 





Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser Met Ala Cys 

                245                 250                 255     





Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn Asn Phe Val 

            260                 265                 270         





Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala Ala Cys Asn 

        275                 280                 285             





Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln Leu Trp Ala 

    290                 295                 300                 





Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr Gly Gly Cys 

305                 310                 315                 320 





Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys Arg Glu Tyr 

                325                 330                 335     





Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu Arg Phe Ser Asn 

            340                 345                 350         





<210>  145

<211>  269

<212>  PRT

<213>  Homo sapiens



<400>  145



Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 

1               5                   10                  15      





Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 

            20                  25                  30          





Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 

        35                  40                  45              





Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 

    50                  55                  60                  





Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 

65                  70                  75                  80  





Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 

                85                  90                  95      





Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 

            100                 105                 110         





Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 

        115                 120                 125             





Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 

    130                 135                 140                 





Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 

145                 150                 155                 160 





Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 

                165                 170                 175     





Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 

            180                 185                 190         





Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 

        195                 200                 205             





Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 

    210                 215                 220                 





Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 

225                 230                 235                 240 





Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 

                245                 250                 255     





Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 

            260                 265                 





<210>  146

<211>  1170

<212>  PRT

<213>  Homo sapiens



<400>  146



Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 

1               5                   10                  15      





Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 

            20                  25                  30          





Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 

        35                  40                  45              





Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 

    50                  55                  60                  





Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 

65                  70                  75                  80  





Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 

                85                  90                  95      





Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 

            100                 105                 110         





Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 

        115                 120                 125             





Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 

    130                 135                 140                 





Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 

145                 150                 155                 160 





Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 

                165                 170                 175     





Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 

            180                 185                 190         





Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 

        195                 200                 205             





Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 

    210                 215                 220                 





Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 

225                 230                 235                 240 





Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 

                245                 250                 255     





Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 

            260                 265                 270         





Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 

        275                 280                 285             





Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 

    290                 295                 300                 





Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 

305                 310                 315                 320 





Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 

                325                 330                 335     





Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 

            340                 345                 350         





Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 

        355                 360                 365             





Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 

    370                 375                 380                 





Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 

385                 390                 395                 400 





Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 

                405                 410                 415     





Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 

            420                 425                 430         





Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 

        435                 440                 445             





Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 

    450                 455                 460                 





Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 

465                 470                 475                 480 





Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 

                485                 490                 495     





Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 

            500                 505                 510         





Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 

        515                 520                 525             





Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 

    530                 535                 540                 





Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 

545                 550                 555                 560 





Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 

                565                 570                 575     





Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 

            580                 585                 590         





Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 

        595                 600                 605             





Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 

    610                 615                 620                 





Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 

625                 630                 635                 640 





Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 

                645                 650                 655     





Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 

            660                 665                 670         





Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 

        675                 680                 685             





Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 

    690                 695                 700                 





Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 

705                 710                 715                 720 





Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 

                725                 730                 735     





Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 

            740                 745                 750         





Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 

        755                 760                 765             





Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 

    770                 775                 780                 





Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 

785                 790                 795                 800 





Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 

                805                 810                 815     





Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 

            820                 825                 830         





Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 

        835                 840                 845             





Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 

    850                 855                 860                 





Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 

865                 870                 875                 880 





Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 

                885                 890                 895     





Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 

            900                 905                 910         





Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 

        915                 920                 925             





Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 

    930                 935                 940                 





Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 

945                 950                 955                 960 





Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 

                965                 970                 975     





Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 

            980                 985                 990         





Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 

        995                 1000                 1005             





Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 

    1010                 1015                 1020             





Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 

    1025                 1030                 1035             





Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 

    1040                 1045                 1050             





Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 

    1055                 1060                 1065             





Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 

    1070                 1075                 1080             





Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 

    1085                 1090                 1095             





His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 

    1100                 1105                 1110             





His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 

    1115                 1120                 1125             





Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 

    1130                 1135                 1140             





Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 

    1145                 1150                 1155             





Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  

    1160                 1165                 1170 





<210>  147

<211>  98

<212>  PRT

<213>  Homo sapiens



<400>  147



Met Ala Ala Glu Pro Leu Thr Glu Leu Glu Glu Ser Ile Glu Thr Val 

1               5                   10                  15      





Val Thr Thr Phe Phe Thr Phe Ala Arg Gln Glu Gly Arg Lys Asp Ser 

            20                  25                  30          





Leu Ser Val Asn Glu Phe Lys Glu Leu Val Thr Gln Gln Leu Pro His 

        35                  40                  45              





Leu Leu Lys Asp Val Gly Ser Leu Asp Glu Lys Met Lys Ser Leu Asp 

    50                  55                  60                  





Val Asn Gln Asp Ser Glu Leu Lys Phe Asn Glu Tyr Trp Arg Leu Ile 

65                  70                  75                  80  





Gly Glu Leu Ala Lys Glu Ile Arg Lys Lys Lys Asp Leu Lys Ile Arg 

                85                  90                  95      





Lys Lys 

        





<210>  148

<211>  765

<212>  PRT

<213>  Homo sapiens



<400>  148



Met Ser Gly Asp His Leu His Asn Asp Ser Gln Ile Glu Ala Asp Phe 

1               5                   10                  15      





Arg Leu Asn Asp Ser His Lys His Lys Asp Lys His Lys Asp Arg Glu 

            20                  25                  30          





His Arg His Lys Glu His Lys Lys Glu Lys Asp Arg Glu Lys Ser Lys 

        35                  40                  45              





His Ser Asn Ser Glu His Lys Asp Ser Glu Lys Lys His Lys Glu Lys 

    50                  55                  60                  





Glu Lys Thr Lys His Lys Asp Gly Ser Ser Glu Lys His Lys Asp Lys 

65                  70                  75                  80  





His Lys Asp Arg Asp Lys Glu Lys Arg Lys Glu Glu Lys Val Arg Ala 

                85                  90                  95      





Ser Gly Asp Ala Lys Ile Lys Lys Glu Lys Glu Asn Gly Phe Ser Ser 

            100                 105                 110         





Pro Pro Gln Ile Lys Asp Glu Pro Glu Asp Asp Gly Tyr Phe Val Pro 

        115                 120                 125             





Pro Lys Glu Asp Ile Lys Pro Leu Lys Arg Pro Arg Asp Glu Asp Asp 

    130                 135                 140                 





Ala Asp Tyr Lys Pro Lys Lys Ile Lys Thr Glu Asp Thr Lys Lys Glu 

145                 150                 155                 160 





Lys Lys Arg Lys Leu Glu Glu Glu Glu Asp Gly Lys Leu Lys Lys Pro 

                165                 170                 175     





Lys Asn Lys Asp Lys Asp Lys Lys Val Pro Glu Pro Asp Asn Lys Lys 

            180                 185                 190         





Lys Lys Pro Lys Lys Glu Glu Glu Gln Lys Trp Lys Trp Trp Glu Glu 

        195                 200                 205             





Glu Arg Tyr Pro Glu Gly Ile Lys Trp Lys Phe Leu Glu His Lys Gly 

    210                 215                 220                 





Pro Val Phe Ala Pro Pro Tyr Glu Pro Leu Pro Glu Asn Val Lys Phe 

225                 230                 235                 240 





Tyr Tyr Asp Gly Lys Val Met Lys Leu Ser Pro Lys Ala Glu Glu Val 

                245                 250                 255     





Ala Thr Phe Phe Ala Lys Met Leu Asp His Glu Tyr Thr Thr Lys Glu 

            260                 265                 270         





Ile Phe Arg Lys Asn Phe Phe Lys Asp Trp Arg Lys Glu Met Thr Asn 

        275                 280                 285             





Glu Glu Lys Asn Ile Ile Thr Asn Leu Ser Lys Cys Asp Phe Thr Gln 

    290                 295                 300                 





Met Ser Gln Tyr Phe Lys Ala Gln Thr Glu Ala Arg Lys Gln Met Ser 

305                 310                 315                 320 





Lys Glu Glu Lys Leu Lys Ile Lys Glu Glu Asn Glu Lys Leu Leu Lys 

                325                 330                 335     





Glu Tyr Gly Phe Cys Ile Met Asp Asn His Lys Glu Arg Ile Ala Asn 

            340                 345                 350         





Phe Lys Ile Glu Pro Pro Gly Leu Phe Arg Gly Arg Gly Asn His Pro 

        355                 360                 365             





Lys Met Gly Met Leu Lys Arg Arg Ile Met Pro Glu Asp Ile Ile Ile 

    370                 375                 380                 





Asn Cys Ser Lys Asp Ala Lys Val Pro Ser Pro Pro Pro Gly His Lys 

385                 390                 395                 400 





Trp Lys Glu Val Arg His Asp Asn Lys Val Thr Trp Leu Val Ser Trp 

                405                 410                 415     





Thr Glu Asn Ile Gln Gly Ser Ile Lys Tyr Ile Met Leu Asn Pro Ser 

            420                 425                 430         





Ser Arg Ile Lys Gly Glu Lys Asp Trp Gln Lys Tyr Glu Thr Ala Arg 

        435                 440                 445             





Arg Leu Lys Lys Cys Val Asp Lys Ile Arg Asn Gln Tyr Arg Glu Asp 

    450                 455                 460                 





Trp Lys Ser Lys Glu Met Lys Val Arg Gln Arg Ala Val Ala Leu Tyr 

465                 470                 475                 480 





Phe Ile Asp Lys Leu Ala Leu Arg Ala Gly Asn Glu Lys Glu Glu Gly 

                485                 490                 495     





Glu Thr Ala Asp Thr Val Gly Cys Cys Ser Leu Arg Val Glu His Ile 

            500                 505                 510         





Asn Leu His Pro Glu Leu Asp Gly Gln Glu Tyr Val Val Glu Phe Asp 

        515                 520                 525             





Phe Leu Gly Lys Asp Ser Ile Arg Tyr Tyr Asn Lys Val Pro Val Glu 

    530                 535                 540                 





Lys Arg Val Phe Lys Asn Leu Gln Leu Phe Met Glu Asn Lys Gln Pro 

545                 550                 555                 560 





Glu Asp Asp Leu Phe Asp Arg Leu Asn Thr Gly Ile Leu Asn Lys His 

                565                 570                 575     





Leu Gln Asp Leu Met Glu Gly Leu Thr Ala Lys Val Phe Arg Thr Tyr 

            580                 585                 590         





Asn Ala Ser Ile Thr Leu Gln Gln Gln Leu Lys Glu Leu Thr Ala Pro 

        595                 600                 605             





Asp Glu Asn Ile Pro Ala Lys Ile Leu Ser Tyr Asn Arg Ala Asn Arg 

    610                 615                 620                 





Ala Val Ala Ile Leu Cys Asn His Gln Arg Ala Pro Pro Lys Thr Phe 

625                 630                 635                 640 





Glu Lys Ser Met Met Asn Leu Gln Thr Lys Ile Asp Ala Lys Lys Glu 

                645                 650                 655     





Gln Leu Ala Asp Ala Arg Arg Asp Leu Lys Ser Ala Lys Ala Asp Ala 

            660                 665                 670         





Lys Val Met Lys Asp Ala Lys Thr Lys Lys Val Val Glu Ser Lys Lys 

        675                 680                 685             





Lys Ala Val Gln Arg Leu Glu Glu Gln Leu Met Lys Leu Glu Val Gln 

    690                 695                 700                 





Ala Thr Asp Arg Glu Glu Asn Lys Gln Ile Ala Leu Gly Thr Ser Lys 

705                 710                 715                 720 





Leu Asn Tyr Leu Asp Pro Arg Ile Thr Val Ala Trp Cys Lys Lys Trp 

                725                 730                 735     





Gly Val Pro Ile Glu Lys Ile Tyr Asn Lys Thr Gln Arg Glu Lys Phe 

            740                 745                 750         





Ala Trp Ala Ile Asp Met Ala Asp Glu Asp Tyr Glu Phe 

        755                 760                 765 





<210>  149

<211>  2477

<212>  PRT

<213>  Homo sapiens



<400>  149



Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 

1               5                   10                  15      





Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 

            20                  25                  30          





Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 

        35                  40                  45              





Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 

    50                  55                  60                  





Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 

65                  70                  75                  80  





Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 

                85                  90                  95      





Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 

            100                 105                 110         





Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 

        115                 120                 125             





Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 

    130                 135                 140                 





Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 

145                 150                 155                 160 





Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 

                165                 170                 175     





Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 

            180                 185                 190         





Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 

        195                 200                 205             





Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 

    210                 215                 220                 





Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 

225                 230                 235                 240 





Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 

                245                 250                 255     





Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 

            260                 265                 270         





His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 

        275                 280                 285             





Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 

    290                 295                 300                 





Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 

305                 310                 315                 320 





Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 

                325                 330                 335     





Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 

            340                 345                 350         





Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 

        355                 360                 365             





Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 

    370                 375                 380                 





Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 

385                 390                 395                 400 





Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 

                405                 410                 415     





Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 

            420                 425                 430         





Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 

        435                 440                 445             





Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 

    450                 455                 460                 





Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 

465                 470                 475                 480 





Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 

                485                 490                 495     





Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 

            500                 505                 510         





Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 

        515                 520                 525             





Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 

    530                 535                 540                 





Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 

545                 550                 555                 560 





Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 

                565                 570                 575     





Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 

            580                 585                 590         





Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 

        595                 600                 605             





Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 

    610                 615                 620                 





Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 

625                 630                 635                 640 





Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 

                645                 650                 655     





Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 

            660                 665                 670         





Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 

        675                 680                 685             





His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 

    690                 695                 700                 





Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 

705                 710                 715                 720 





Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 

                725                 730                 735     





Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 

            740                 745                 750         





Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 

        755                 760                 765             





Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 

    770                 775                 780                 





Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 

785                 790                 795                 800 





Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 

                805                 810                 815     





Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 

            820                 825                 830         





Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 

        835                 840                 845             





Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 

    850                 855                 860                 





Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 

865                 870                 875                 880 





Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 

                885                 890                 895     





Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 

            900                 905                 910         





Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 

        915                 920                 925             





Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 

    930                 935                 940                 





Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 

945                 950                 955                 960 





Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 

                965                 970                 975     





Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 

            980                 985                 990         





Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 

        995                 1000                 1005             





Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 

    1010                 1015                 1020             





Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 

    1025                 1030                 1035             





Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 

    1040                 1045                 1050             





Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 

    1055                 1060                 1065             





Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 

    1070                 1075                 1080             





Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 

    1085                 1090                 1095             





Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 

    1100                 1105                 1110             





Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 

    1115                 1120                 1125             





Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 

    1130                 1135                 1140             





Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 

    1145                 1150                 1155             





Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 

    1160                 1165                 1170             





Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 

    1175                 1180                 1185             





Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 

    1190                 1195                 1200             





Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 

    1205                 1210                 1215             





Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 

    1220                 1225                 1230             





Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 

    1235                 1240                 1245             





Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 

    1250                 1255                 1260             





Ile Pro  Glu Val Pro Gln Leu  Thr Asp Leu Ser Phe  Val Asp Ile 

    1265                 1270                 1275             





Thr Asp  Ser Ser Ile Gly Leu  Arg Trp Thr Pro Leu  Asn Ser Ser 

    1280                 1285                 1290             





Thr Ile  Ile Gly Tyr Arg Ile  Thr Val Val Ala Ala  Gly Glu Gly 

    1295                 1300                 1305             





Ile Pro  Ile Phe Glu Asp Phe  Val Asp Ser Ser Val  Gly Tyr Tyr 

    1310                 1315                 1320             





Thr Val  Thr Gly Leu Glu Pro  Gly Ile Asp Tyr Asp  Ile Ser Val 

    1325                 1330                 1335             





Ile Thr  Leu Ile Asn Gly Gly  Glu Ser Ala Pro Thr  Thr Leu Thr 

    1340                 1345                 1350             





Gln Gln  Thr Ala Val Pro Pro  Pro Thr Asp Leu Arg  Phe Thr Asn 

    1355                 1360                 1365             





Ile Gly  Pro Asp Thr Met Arg  Val Thr Trp Ala Pro  Pro Pro Ser 

    1370                 1375                 1380             





Ile Asp  Leu Thr Asn Phe Leu  Val Arg Tyr Ser Pro  Val Lys Asn 

    1385                 1390                 1395             





Glu Glu  Asp Val Ala Glu Leu  Ser Ile Ser Pro Ser  Asp Asn Ala 

    1400                 1405                 1410             





Val Val  Leu Thr Asn Leu Leu  Pro Gly Thr Glu Tyr  Val Val Ser 

    1415                 1420                 1425             





Val Ser  Ser Val Tyr Glu Gln  His Glu Ser Thr Pro  Leu Arg Gly 

    1430                 1435                 1440             





Arg Gln  Lys Thr Gly Leu Asp  Ser Pro Thr Gly Ile  Asp Phe Ser 

    1445                 1450                 1455             





Asp Ile  Thr Ala Asn Ser Phe  Thr Val His Trp Ile  Ala Pro Arg 

    1460                 1465                 1470             





Ala Thr  Ile Thr Gly Tyr Arg  Ile Arg His His Pro  Glu His Phe 

    1475                 1480                 1485             





Ser Gly  Arg Pro Arg Glu Asp  Arg Val Pro His Ser  Arg Asn Ser 

    1490                 1495                 1500             





Ile Thr  Leu Thr Asn Leu Thr  Pro Gly Thr Glu Tyr  Val Val Ser 

    1505                 1510                 1515             





Ile Val  Ala Leu Asn Gly Arg  Glu Glu Ser Pro Leu  Leu Ile Gly 

    1520                 1525                 1530             





Gln Gln  Ser Thr Val Ser Asp  Val Pro Arg Asp Leu  Glu Val Val 

    1535                 1540                 1545             





Ala Ala  Thr Pro Thr Ser Leu  Leu Ile Ser Trp Asp  Ala Pro Ala 

    1550                 1555                 1560             





Val Thr  Val Arg Tyr Tyr Arg  Ile Thr Tyr Gly Glu  Thr Gly Gly 

    1565                 1570                 1575             





Asn Ser  Pro Val Gln Glu Phe  Thr Val Pro Gly Ser  Lys Ser Thr 

    1580                 1585                 1590             





Ala Thr  Ile Ser Gly Leu Lys  Pro Gly Val Asp Tyr  Thr Ile Thr 

    1595                 1600                 1605             





Val Tyr  Ala Val Thr Gly Arg  Gly Asp Ser Pro Ala  Ser Ser Lys 

    1610                 1615                 1620             





Pro Ile  Ser Ile Asn Tyr Arg  Thr Glu Ile Asp Lys  Pro Ser Gln 

    1625                 1630                 1635             





Met Gln  Val Thr Asp Val Gln  Asp Asn Ser Ile Ser  Val Lys Trp 

    1640                 1645                 1650             





Leu Pro  Ser Ser Ser Pro Val  Thr Gly Tyr Arg Val  Thr Thr Thr 

    1655                 1660                 1665             





Pro Lys  Asn Gly Pro Gly Pro  Thr Lys Thr Lys Thr  Ala Gly Pro 

    1670                 1675                 1680             





Asp Gln  Thr Glu Met Thr Ile  Glu Gly Leu Gln Pro  Thr Val Glu 

    1685                 1690                 1695             





Tyr Val  Val Ser Val Tyr Ala  Gln Asn Pro Ser Gly  Glu Ser Gln 

    1700                 1705                 1710             





Pro Leu  Val Gln Thr Ala Val  Thr Asn Ile Asp Arg  Pro Lys Gly 

    1715                 1720                 1725             





Leu Ala  Phe Thr Asp Val Asp  Val Asp Ser Ile Lys  Ile Ala Trp 

    1730                 1735                 1740             





Glu Ser  Pro Gln Gly Gln Val  Ser Arg Tyr Arg Val  Thr Tyr Ser 

    1745                 1750                 1755             





Ser Pro  Glu Asp Gly Ile His  Glu Leu Phe Pro Ala  Pro Asp Gly 

    1760                 1765                 1770             





Glu Glu  Asp Thr Ala Glu Leu  Gln Gly Leu Arg Pro  Gly Ser Glu 

    1775                 1780                 1785             





Tyr Thr  Val Ser Val Val Ala  Leu His Asp Asp Met  Glu Ser Gln 

    1790                 1795                 1800             





Pro Leu  Ile Gly Thr Gln Ser  Thr Ala Ile Pro Ala  Pro Thr Asp 

    1805                 1810                 1815             





Leu Lys  Phe Thr Gln Val Thr  Pro Thr Ser Leu Ser  Ala Gln Trp 

    1820                 1825                 1830             





Thr Pro  Pro Asn Val Gln Leu  Thr Gly Tyr Arg Val  Arg Val Thr 

    1835                 1840                 1845             





Pro Lys  Glu Lys Thr Gly Pro  Met Lys Glu Ile Asn  Leu Ala Pro 

    1850                 1855                 1860             





Asp Ser  Ser Ser Val Val Val  Ser Gly Leu Met Val  Ala Thr Lys 

    1865                 1870                 1875             





Tyr Glu  Val Ser Val Tyr Ala  Leu Lys Asp Thr Leu  Thr Ser Arg 

    1880                 1885                 1890             





Pro Ala  Gln Gly Val Val Thr  Thr Leu Glu Asn Val  Ser Pro Pro 

    1895                 1900                 1905             





Arg Arg  Ala Arg Val Thr Asp  Ala Thr Glu Thr Thr  Ile Thr Ile 

    1910                 1915                 1920             





Ser Trp  Arg Thr Lys Thr Glu  Thr Ile Thr Gly Phe  Gln Val Asp 

    1925                 1930                 1935             





Ala Val  Pro Ala Asn Gly Gln  Thr Pro Ile Gln Arg  Thr Ile Lys 

    1940                 1945                 1950             





Pro Asp  Val Arg Ser Tyr Thr  Ile Thr Gly Leu Gln  Pro Gly Thr 

    1955                 1960                 1965             





Asp Tyr  Lys Ile Tyr Leu Tyr  Thr Leu Asn Asp Asn  Ala Arg Ser 

    1970                 1975                 1980             





Ser Pro  Val Val Ile Asp Ala  Ser Thr Ala Ile Asp  Ala Pro Ser 

    1985                 1990                 1995             





Asn Leu  Arg Phe Leu Ala Thr  Thr Pro Asn Ser Leu  Leu Val Ser 

    2000                 2005                 2010             





Trp Gln  Pro Pro Arg Ala Arg  Ile Thr Gly Tyr Ile  Ile Lys Tyr 

    2015                 2020                 2025             





Glu Lys  Pro Gly Ser Pro Pro  Arg Glu Val Val Pro  Arg Pro Arg 

    2030                 2035                 2040             





Pro Gly  Val Thr Glu Ala Thr  Ile Thr Gly Leu Glu  Pro Gly Thr 

    2045                 2050                 2055             





Glu Tyr  Thr Ile Tyr Val Ile  Ala Leu Lys Asn Asn  Gln Lys Ser 

    2060                 2065                 2070             





Glu Pro  Leu Ile Gly Arg Lys  Lys Thr Asp Glu Leu  Pro Gln Leu 

    2075                 2080                 2085             





Val Thr  Leu Pro His Pro Asn  Leu His Gly Pro Glu  Ile Leu Asp 

    2090                 2095                 2100             





Val Pro  Ser Thr Val Gln Lys  Thr Pro Phe Val Thr  His Pro Gly 

    2105                 2110                 2115             





Tyr Asp  Thr Gly Asn Gly Ile  Gln Leu Pro Gly Thr  Ser Gly Gln 

    2120                 2125                 2130             





Gln Pro  Ser Val Gly Gln Gln  Met Ile Phe Glu Glu  His Gly Phe 

    2135                 2140                 2145             





Arg Arg  Thr Thr Pro Pro Thr  Thr Ala Thr Pro Ile  Arg His Arg 

    2150                 2155                 2160             





Pro Arg  Pro Tyr Pro Pro Asn  Val Gly Glu Glu Ile  Gln Ile Gly 

    2165                 2170                 2175             





His Ile  Pro Arg Glu Asp Val  Asp Tyr His Leu Tyr  Pro His Gly 

    2180                 2185                 2190             





Pro Gly  Leu Asn Pro Asn Ala  Ser Thr Gly Gln Glu  Ala Leu Ser 

    2195                 2200                 2205             





Gln Thr  Thr Ile Ser Trp Ala  Pro Phe Gln Asp Thr  Ser Glu Tyr 

    2210                 2215                 2220             





Ile Ile  Ser Cys His Pro Val  Gly Thr Asp Glu Glu  Pro Leu Gln 

    2225                 2230                 2235             





Phe Arg  Val Pro Gly Thr Ser  Thr Ser Ala Thr Leu  Thr Gly Leu 

    2240                 2245                 2250             





Thr Arg  Gly Ala Thr Tyr Asn  Val Ile Val Glu Ala  Leu Lys Asp 

    2255                 2260                 2265             





Gln Gln  Arg His Lys Val Arg  Glu Glu Val Val Thr  Val Gly Asn 

    2270                 2275                 2280             





Ser Val  Asn Glu Gly Leu Asn  Gln Pro Thr Asp Asp  Ser Cys Phe 

    2285                 2290                 2295             





Asp Pro  Tyr Thr Val Ser His  Tyr Ala Val Gly Asp  Glu Trp Glu 

    2300                 2305                 2310             





Arg Met  Ser Glu Ser Gly Phe  Lys Leu Leu Cys Gln  Cys Leu Gly 

    2315                 2320                 2325             





Phe Gly  Ser Gly His Phe Arg  Cys Asp Ser Ser Arg  Trp Cys His 

    2330                 2335                 2340             





Asp Asn  Gly Val Asn Tyr Lys  Ile Gly Glu Lys Trp  Asp Arg Gln 

    2345                 2350                 2355             





Gly Glu  Asn Gly Gln Met Met  Ser Cys Thr Cys Leu  Gly Asn Gly 

    2360                 2365                 2370             





Lys Gly  Glu Phe Lys Cys Asp  Pro His Glu Ala Thr  Cys Tyr Asp 

    2375                 2380                 2385             





Asp Gly  Lys Thr Tyr His Val  Gly Glu Gln Trp Gln  Lys Glu Tyr 

    2390                 2395                 2400             





Leu Gly  Ala Ile Cys Ser Cys  Thr Cys Phe Gly Gly  Gln Arg Gly 

    2405                 2410                 2415             





Trp Arg  Cys Asp Asn Cys Arg  Arg Pro Gly Gly Glu  Pro Ser Pro 

    2420                 2425                 2430             





Glu Gly  Thr Thr Gly Gln Ser  Tyr Asn Gln Tyr Ser  Gln Arg Tyr 

    2435                 2440                 2445             





His Gln  Arg Thr Asn Thr Asn  Val Asn Cys Pro Ile  Glu Cys Phe 

    2450                 2455                 2460             





Met Pro  Leu Asp Val Gln Ala  Asp Arg Glu Asp Ser  Arg Glu 

    2465                 2470                 2475         





<210>  150

<211>  91

<212>  PRT

<213>  Homo sapiens



<400>  150



Met Lys Leu Ala Val Thr Leu Thr Leu Val Thr Leu Ala Leu Cys Cys 

1               5                   10                  15      





Ser Ser Ala Ser Ala Glu Ile Cys Pro Ser Phe Gln Arg Val Ile Glu 

            20                  25                  30          





Thr Leu Leu Met Asp Thr Pro Ser Ser Tyr Glu Ala Ala Met Glu Leu 

        35                  40                  45              





Phe Ser Pro Asp Gln Asp Met Arg Glu Ala Gly Ala Gln Leu Lys Lys 

    50                  55                  60                  





Leu Val Asp Thr Leu Pro Gln Lys Pro Arg Glu Ser Ile Ile Lys Leu 

65                  70                  75                  80  





Met Glu Lys Ile Ala Gln Ser Ser Leu Cys Asn 

                85                  90      





<210>  151

<211>  375

<212>  PRT

<213>  Homo sapiens



<400>  151



Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 

1               5                   10                  15      





Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 

            20                  25                  30          





Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 

        35                  40                  45              





Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 

    50                  55                  60                  





Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 

65                  70                  75                  80  





Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 

                85                  90                  95      





Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 

            100                 105                 110         





Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 

        115                 120                 125             





Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 

    130                 135                 140                 





Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 

145                 150                 155                 160 





Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 

                165                 170                 175     





Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 

            180                 185                 190         





Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 

        195                 200                 205             





Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 

    210                 215                 220                 





Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 

225                 230                 235                 240 





Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 

                245                 250                 255     





Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 

            260                 265                 270         





Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 

        275                 280                 285             





Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 

    290                 295                 300                 





Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 

305                 310                 315                 320 





Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 

                325                 330                 335     





Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 

            340                 345                 350         





Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 

        355                 360                 365             





Gln Gly Ala Arg Gly Phe Ala 

    370                 375 





<210>  152

<211>  191

<212>  PRT

<213>  Homo sapiens



<400>  152



Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 

1               5                   10                  15      





Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 

            20                  25                  30          





Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 

        35                  40                  45              





Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 

    50                  55                  60                  





Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 

65                  70                  75                  80  





Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 

                85                  90                  95      





Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 

            100                 105                 110         





Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 

        115                 120                 125             





Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 

    130                 135                 140                 





Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 

145                 150                 155                 160 





Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 

                165                 170                 175     





Leu Glu Leu Asn Glu Arg Thr Cys Arg Ser Leu Thr Arg Lys Asp 

            180                 185                 190     





