                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  Compounds and Methods Targeting Human and Mouse INSL5

<130>  X22808

<150>  US 63/060,701
<151>  2020-08-04

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Asp Leu Gln Thr Leu Cys Cys Thr Asp Gly Cys Ser Met Thr Asp 
1               5                   10                  15      


Leu Ser Ala Leu Cys 
            20      


<210>  2
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Glu Ser Val Arg Leu Cys Gly Leu Glu Tyr Ile Arg Thr Val Ile 
1               5                   10                  15      


Tyr Ile Cys Ala Ser Ser Arg Trp 
            20                  


<210>  3
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  3

Arg Asp Leu Gln Ala Leu Cys Cys Arg Glu Gly Cys Ser Met Lys Glu 
1               5                   10                  15      


Leu Ser Thr Leu Cys 
            20      


<210>  4
<211>  24
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Gln Thr Val Lys Leu Cys Gly Leu Asp Tyr Val Arg Thr Val Ile 
1               5                   10                  15      


Tyr Ile Cys Ala Ser Ser Arg Trp 
            20                  


<210>  5
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Gly Trp Val Arg Gln Thr Pro Gly Glu Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Thr Ile Ser Ala Gly Gly Tyr Thr Tyr Tyr Ala His Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Arg 
                85                  90                  95      


Trp Asn Tyr Asp Arg Ser Gly Gly Ala Gly Ala Gly Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser 
    130                 135                 140                 


Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe 
                165                 170                 175     


Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser 
    210                 215                 220                 


Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
        275                 280                 285             


Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
    290                 295                 300                 


Leu Pro Ile Thr His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
            340                 345                 350         


Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
    370                 375                 380                 


Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu Trp 
                405                 410                 415     


Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
        435                 440                 445     


<210>  6
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcagtagc tacgacatgg gctgggtccg ccagactcca      120

ggggaggggc tggaatgggt cggaaccatt agtgctggtg gttacacgta ctacgcgcac      180

tgggcgaaag gccgattcac catctccaaa tcctcgacca cggtggatct gaaaatgacc      240

agtctgacga ccgaggacac ggccacctat ttctgtgcca gagaaagatg gaattacgat      300

aggtctggtg gtgctggtgc tggctacttt gacttgtggg gcccaggcac cctggtcacc      360

gtctcctcag ggcaacctaa ggctccatca gtctttcccc tcgcaccttg ctgtggtgac      420

acgccctcat ccacggtaac actgggctgt cttgtcaaag gataccttcc ggagccagtc      480

acagtaacgt ggaactcggg aacattgaca aacggcgtaa gaacgtttcc gtcggtacgt      540

caaagttcag gcctctactc gctcagctcc gtagtatcgg tgacctcatc cagccagccg      600

gtgacttgca acgtggcgca tcccgcgacc aacacaaaag tggataagac cgttgcaccc      660

tcaacttgct ccaagcccac gtgtccccca ccagagctgc tcggtgggcc ctcggtcttt      720

atcttccctc cgaaacccaa agacacattg atgatctctc gcacgccgga agtcacgtgc      780

gtggtcgtgg acgtcagcca agatgacccg gaagtgcaat tcacctggta tatcaataac      840

gaacaggtca gaacggctcg gcctcctttg cgagaacaac agttcaattc cactatcagg      900

gttgtatcaa cacttcccat cacacaccaa gattggctta ggggaaagga gtttaagtgt      960

aaagtgcaca ataaggcttt gccagcgcct attgagaaaa ccatttccaa agcccgtggg     1020

caaccgcttg aacccaaagt ctatacaatg gggccaccca gagaggaact gtcgagccgc     1080

tccgtgtcac tgacttgtat gatcaatggg ttctatccgt cggacatttc ggtggaatgg     1140

gagaagaatg gaaaagcaga ggataactac aaaactacgc cagccgtgtt ggactctgac     1200

gggtcatact ttctgtacaa taagctctct gtccccacgt cggaatggca gaggggagat     1260

gtgtttactt gctcggtgat gcatgaggcg ctccataatc actataccca gaaaagcatc     1320

agtcgaagcc ctgggaaa                                                   1338


<210>  7
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Ala Asp Val Val Met Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Thr Ser 
            20                  25                  30          


Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Pro Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Tyr Gly Tyr Phe Ser 
                85                  90                  95      


Ser Ser Ile Asp Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Arg 
            100                 105                 110         


Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
        115                 120                 125             


Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
    130                 135                 140                 


Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
145                 150                 155                 160 


Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr 
                165                 170                 175     


Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
            180                 185                 190         


His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
        195                 200                 205             


Gln Ser Phe Asn Arg Gly Asp Cys 
    210                 215     


<210>  8
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
gccgatgtcg tgatgaccca gactgcatcc cccgtgtctg cagctgtggg aggcacagtc       60

accatcaatt gccaggccag tcagagtatt actagtagct acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcctgatc tatcctgcag ccaatctggc atctggagtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgacg atgctgccac ttactactgt ctatacggtt attttagttc tagtattgat      300

tttgctttcg gcggagggac cgaggtggtg gtcagaggtg atccagttgc acctactgtc      360

ctcatcttcc caccagctgc tgatcaagtc gcaacaggta ctgtgacgat cgtgtgtgtc      420

gcgaacaaat actttcccga cgtgaccgtg acgtgggaag tcgacggaac aacccagacg      480

accgggatcg aaaactcaaa gaccccgcaa aactcggccg attgcacata caatttgtcc      540

tctacgctta cactcacgtc gacgcagtac aatagtcaca aggagtatac atgcaaagtt      600

actcaaggaa ctacgagcgt ggtccagtca ttcaatagag gggattgt                   648


<210>  9
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Gly Trp Val Arg Gln Thr Pro Gly Glu Gly Leu Glu Trp Val Gly 
        35                  40                  45              


Thr Ile Ser Ala Gly Gly Tyr Thr Tyr Tyr Ala His Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ser Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Arg 
                85                  90                  95      


Trp Asn Tyr Asp Arg Ser Gly Gly Ala Gly Ala Gly Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp Met Gly 
1               5                   10              


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Thr Ile Ser Ala Gly Gly Tyr Thr Tyr 
1               5                   


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Ala Arg Glu Arg Trp Asn Tyr Asp Arg Ser Gly Gly Ala Gly Ala Gly 
1               5                   10                  15      


Tyr Phe Asp Leu 
            20  


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Ala Asp Val Val Met Thr Gln Thr Ala Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Thr Ser 
            20                  25                  30          


Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Pro Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Tyr Gly Tyr Phe Ser 
                85                  90                  95      


Ser Ser Ile Asp Phe Ala Phe Gly Gly Gly Thr Glu Val Val Val Arg 
            100                 105                 110         


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Ala Ser Gln Ser Ile Thr Ser Ser Tyr Leu Ser 
1               5                   10          


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Tyr Pro Ala Ala Asn Leu Ala Ser 
1               5               


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Leu Tyr Gly Tyr Phe Ser Ser Ser Ile Asp Phe Ala 
1               5                   10          


<210>  17
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Thr Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Gly Gly Gly Gly Arg Thr Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Pro Ala Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly Gly 
                85                  90                  95      


Asp Phe Phe Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
        115                 120                 125             


Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
145                 150                 155                 160 


Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
            180                 185                 190         


Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
        195                 200                 205             


Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
    210                 215                 220                 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                245                 250                 255     


Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
            260                 265                 270         


Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
        275                 280                 285             


Arg Val Val Ser Thr Leu Pro Ile Thr His Gln Asp Trp Leu Arg Gly 
    290                 295                 300                 


Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
                325                 330                 335     


Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
            340                 345                 350         


Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
        355                 360                 365             


Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val 
385                 390                 395                 400 


Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
            420                 425                 430         


Pro Gly Lys 
        435 


<210>  18
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
cagtcggtgg aggagtccgg aggaggcctg gtaacgcctg gaggatccct gacactcacc       60

tgcacagtct ctggaatcga cctcactacc tatgcaatgg gctgggtccg ccaggctcca      120

ggggaggggc tggaatggat cggaattatt ggtggtggtg gtcgaacata ctacgcggcc      180

tgggcgaaag gccgcttcac catctccaaa acctcgacca cggtggatct gagaatcacc      240

agtccggcaa ccgaggacac ggccacctat ttctgtgtca gaggaggaga cttctttgac      300

ttgtggggcc caggcaccct ggtcaccgtc tcctcagggc aacctaaggc tccatcagtc      360

tttcccctcg caccttgctg tggtgacacg ccctcatcca cggtaacact gggctgtctt      420

gtcaaaggat accttccgga gccagtcaca gtaacgtgga actcgggaac attgacaaac      480

ggcgtaagaa cgtttccgtc ggtacgtcaa agttcaggcc tctactcgct cagctccgta      540

gtatcggtga cctcatccag ccagccggtg acttgcaacg tggcgcatcc cgcgaccaac      600

acaaaagtgg ataagaccgt tgcaccctca acttgctcca agcccacgtg tcccccacca      660

gagctgctcg gtgggccctc ggtctttatc ttccctccga aacccaaaga cacattgatg      720

atctctcgca cgccggaagt cacgtgcgtg gtcgtggacg tcagccaaga tgacccggaa      780

gtgcaattca cctggtatat caataacgaa caggtcagaa cggctcggcc tcctttgcga      840

gaacaacagt tcaattccac tatcagggtt gtatcaacac ttcccatcac acaccaagat      900

tggcttaggg gaaaggagtt taagtgtaaa gtgcacaata aggctttgcc agcgcctatt      960

gagaaaacca tttccaaagc ccgtgggcaa ccgcttgaac ccaaagtcta tacaatgggg     1020

ccacccagag aggaactgtc gagccgctcc gtgtcactga cttgtatgat caatgggttc     1080

tatccgtcgg acatttcggt ggaatgggag aagaatggaa aagcagagga taactacaaa     1140

actacgccag ccgtgttgga ctctgacggg tcatactttc tgtacaataa gctctctgtc     1200

cccacgtcgg aatggcagag gggagatgtg tttacttgct cggtgatgca tgaggcgctc     1260

cataatcact atacccagaa aagcatcagt cgaagccctg ggaaa                     1305


<210>  19
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Val Ser Asn Leu Glu Phe Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Gly Tyr Thr Gly Val Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Arg Gly Asp 
            100                 105                 110         


Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val 
        115                 120                 125             


Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro 
    130                 135                 140                 


Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly 
145                 150                 155                 160 


Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys 
            180                 185                 190         


Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser 
        195                 200                 205             


Phe Asn Arg Gly Asp Cys 
    210                 


<210>  20
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
gctcaagtgc tgacccagac tccagcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtga ggatattagc aagtacttat cctggtatca gcagaaacca      120

gggcagcgcc ccaaactcct gatctattat gtatccaatc tggaatttgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt      240

gacgatgctg ccacttacta ctgtcaccag ggttataccg gtgttaatgt tgaaaatgtt      300

ttcggcggag ggaccgaggt ggtggtcaga ggtgatccag ttgcacctac tgtcctcatc      360

ttcccaccag ctgctgatca agtcgcaaca ggtactgtga cgatcgtgtg tgtcgcgaac      420

aaatactttc ccgacgtgac cgtgacgtgg gaagtcgacg gaacaaccca gacgaccggg      480

atcgaaaact caaagacccc gcaaaactcg gccgattgca catacaattt gtcctctacg      540

cttacactca cgtcgacgca gtacaatagt cacaaggagt atacatgcaa agttactcaa      600

ggaactacga gcgtggtcca gtcattcaat agaggggatt gt                         642


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Thr Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Gly Gly Gly Gly Arg Thr Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Pro Ala Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Gly Gly 
                85                  90                  95      


Asp Phe Phe Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Thr Val Ser Gly Ile Asp Leu Thr Thr Tyr Ala Met Gly 
1               5                   10              


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Ile Ile Gly Gly Gly Gly Arg Thr Tyr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Val Arg Gly Gly Asp Phe Phe Asp Leu 
1               5                   


<210>  25
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Ala Gln Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Val Ser Asn Leu Glu Phe Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys His Gln Gly Tyr Thr Gly Val Asn 
                85                  90                  95      


Val Glu Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Arg 
            100                 105                 110 


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gln Ala Ser Glu Asp Ile Ser Lys Tyr Leu Ser 
1               5                   10      


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Tyr Tyr Val Ser Asn Leu Glu Phe 
1               5               


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

His Gln Gly Tyr Thr Gly Val Asn Val Glu Asn Val 
1               5                   10          


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


