                         SEQUENCE LISTING

<110>  PREVAIL THERAPEUTICS, INC.
 
<120>  AAV VECTORS ENCODING PARKIN AND USES THEREOF

<130>  P1094.70015WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/060,353
<151>  2020-08-03

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15      


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30          


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45              


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60                  


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80  


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95      


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110         


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125             


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140                 


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160 


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175     


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190         


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205             


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Ser Val 
    210                 215                 220                 


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240 


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255     


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270         


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285             


Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe 
    290                 295                 300                 


Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala 
305                 310                 315                 320 


Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly 
                325                 330                 335     


Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys 
            340                 345                 350         


Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys 
        355                 360                 365             


Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser 
    370                 375                 380                 


Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln 
385                 390                 395                 400 


Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys 
                405                 410                 415     


Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys Met 
            420                 425                 430         


His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn 
        435                 440                 445             


Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe Asp 
    450                 455                 460                 


Val 
465 


<210>  2
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  2
atgattgttt tcgtcagatt caatagttcc cacgggttcc ctgtcgaggt ggacagtgat       60

actagcatct tccagctgaa agaagtggtg gcgaagcggc agggagttcc tgcagaccaa      120

ctgagggtca ttttcgccgg caaggagctg aggaacgatt ggactgtgca gaactgtgac      180

cttgatcagc agagtatcgt tcacatagtg cagcgcccgt ggaggaaggg gcaggagatg      240

aacgcaacgg gcggggacga ccccagaaat gctgcggggg gttgcgagcg ggaacctcag      300

tctctgactc gggtggacct gtctagctct gtgctcccag gtgatagcgt tggcctcgct      360

gttatcctgc atacagactc caggaaggat agtcctcccg ccgggtctcc tgccggccga      420

agtatctata actcatttta cgtttactgc aaaggaccct gccaacgcgt acaacccggc      480

aagctccgcg tgcaatgctc aacttgtagg caggccacac tcactttgac gcaaggtccc      540

tcttgctggg acgatgtgct gattccgaat agaatgagtg gcgagtgcca atcaccccat      600

tgtcccggta caagcgcgga attcttcttc aaatgcggcg cacatcccac gtcagacaaa      660

gagacttcag tcgctctcca cctgatagcc accaactccc gcaacattac ctgtataact      720

tgcacggatg tccgctcccc cgtgttggtg ttccagtgta actccagaca tgtgatctgt      780

ctggactgct ttcacctgta ctgcgtgact agacttaatg acagacagtt tgtacatgac      840

ccccagctgg gatacagcct gccgtgcgtg gccggttgtc ccaacagcct gattaaggag      900

ctgcaccatt tcaggatcct gggcgaggag cagtacaaca gataccagca gtacggggcg      960

gaggagtgtg ttcttcagat ggggggggtg ctgtgcccca ggcccggctg cggtgctggt     1020

ctgttgccag agcccgacca gagaaaggtc acatgtgagg gcggtaatgg gcttggctgt     1080

ggatttgcct tctgcaggga atgtaaagag gcctaccacg agggcgaatg cagtgccgtt     1140

ttcgaagcaa gtggcaccac aacacaggcc tatagagttg atgaaagggc agcagaacaa     1200

gcgaggtggg aagccgcctc caaagaaact atcaaaaaaa cgacaaagcc atgccccagg     1260

tgccatgtgc ctgtggagaa aaacggggga tgcatgcata tgaaatgtcc ccagccccag     1320

tgccggttgg agtggtgttg gaactgtggc tgcgaatgga atcgggtctg catgggggac     1380

cactggtttg acgtg                                                      1395


<210>  3
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  3
atgattgtgt tcgttcgatt caattcatcc catggatttc cagtcgaggt cgattcagat       60

acctccatat tccagctcaa agaagttgtc gcaaagaggc aaggagtgcc agccgaccag      120

ctgcgagtca tctttgccgg aaaggagttg aggaacgact ggaccgttca aaattgtgac      180

ctggaccagc agtcaatagt gcacatcgtg caaaggcctt ggcggaaggg tcaagagatg      240

aacgctactg gtggcgacga tcctcggaat gcagcaggcg gctgcgaacg agagcctcag      300

agccttacca gggtagattt gtcatccagc gtattgcctg gtgactcagt aggactggct      360

gtaattcttc atacagacag caggaaagat agcccaccag ccggcagccc cgctggtaga      420

agtatctaca actcattcta cgtctattgc aaagggccgt gtcagcgggt gcaaccgggt      480

aaactcagag tccaatgcag cacctgtaga caagctacac tgacacttac acaagggcct      540

agttgttggg acgacgttct tattcccaat agaatgtcag gtgagtgtca aagtcctcat      600

tgtccgggga ctagtgctga gttttttttc aaatgcggcg ctcaccccac tagtgacaag      660

gagacaagcg tggccctgca tctcatagcg acgaatagca gaaacataac atgcatcact      720

tgcacggacg ttcggtcacc tgtgcttgtg tttcaatgta acagccggca tgtcatttgt      780

cttgattgct ttcacctcta ctgtgtgaca cgcttgaatg acagacaatt cgtccatgac      840

ccacaattgg gatacagttt gccctgcgta gcgggttgtc caaattcttt gattaaggag      900

ctgcatcact ttcggatcct gggagaagag cagtacaatc gataccagca gtatggagct      960

gaagagtgtg tgctccaaat gggcggggtt ctttgtcccc ggcctggctg cggcgccggt     1020

ttgctccccg aaccagatca gcggaaagtt acatgtgagg gtggaaatgg tcttggctgt     1080

ggcttcgcgt tctgccggga gtgcaaagaa gcgtaccatg aaggggagtg cagcgcagtt     1140

tttgaggcaa gtggcacgac gacccaggct taccgggtag acgaacgcgc agcagagcag     1200

gccagatggg aagcggcctc caaggagacc attaaaaaga caaccaaacc ttgtcctcgg     1260

tgtcacgtgc ccgtcgagaa gaacgggggc tgtatgcata tgaaatgccc acaaccgcaa     1320

tgtaggctgg aatggtgttg gaactgcggc tgcgaatgga atagggtgtg tatgggagac     1380

cattggtttg acgtctag                                                   1398


<210>  4
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  4
atgatagtgt ttgtcaggtt caactccagc catggtttcc cagtggaggt cgattctgac       60

accagcatct tccagctcaa ggaggtggtt gctaagcgac agggggttcc ggctgaccag      120

ttgcgtgtga ttttcgcagg gaaggagctg aggaatgact ggactgtgca gaattgtgac      180

ctggatcagc agagcattgt tcacattgtg cagagaccgt ggagaaaagg tcaagaaatg      240

aatgcaactg gaggcgacga ccccagaaac gcggcgggag gctgtgagcg ggagccccag      300

agcttgactc gggtggacct cagcagctca gtcctcccag gagactctgt ggggctggct      360

gtcattctgc acactgacag caggaaggac tcaccaccag ctggaagtcc agcaggtaga      420

tcaatctaca acagctttta tgtgtattgc aaaggcccct gtcaaagagt gcagccggga      480

aaactcaggg tacagtgcag cacctgcagg caggcaacgc tcaccttgac ccagggtcca      540

tcttgctggg atgatgtttt aattccaaac cggatgagtg gtgaatgcca atccccacac      600

tgccctggga ctagtgcaga atttttcttt aaatgtggag cacaccccac ctctgacaag      660

gaaacatcag tagctttgca cctgatcgca acaaatagtc ggaacatcac ttgcattacg      720

tgcacagacg tcaggagccc cgtcctggtt ttccagtgca actcccgcca cgtgatttgc      780

ttagactgtt tccacttata ctgtgtgaca agactcaatg atcggcagtt tgttcacgac      840

cctcaacttg gctactccct gccttgtgtg gctggctgtc ccaactcctt gattaaagag      900

ctccatcact tcaggattct gggagaagag cagtacaacc ggtaccagca gtatggtgca      960

gaggagtgtg tcctgcagat ggggggcgtg ttatgccccc gccctggctg tggagcgggg     1020

ctgctgccgg agcctgacca gaggaaagtc acctgcgaag ggggcaatgg cctgggctgt     1080

gggtttgcct tctgccggga atgtaaagaa gcgtaccatg aaggggagtg cagtgccgta     1140

tttgaagcct caggaacaac tactcaggcc tacagagtcg atgaaagagc cgccgagcag     1200

gctcgttggg aagcagcctc caaagaaacc atcaagaaaa ccaccaagcc ctgtccccgc     1260

tgccatgtac cagtggaaaa aaatggaggc tgcatgcaca tgaagtgtcc gcagccccag     1320

tgcaggctcg agtggtgctg gaactgtggc tgcgagtgga accgcgtctg catgggggac     1380

cactggttcg acgtgtag                                                   1398


<210>  5
<211>  145
<212>  DNA
<213>  Homo sapiens

<400>  5
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  6
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15      


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30          


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45              


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60                  


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80  


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95      


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110         


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125             


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140                 


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160 


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175     


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190         


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205             


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Pro Val 
    210                 215                 220                 


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240 


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255     


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270         


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285             


Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe 
    290                 295                 300                 


Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala 
305                 310                 315                 320 


Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly 
                325                 330                 335     


Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys 
            340                 345                 350         


Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys 
        355                 360                 365             


Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser 
    370                 375                 380                 


Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln 
385                 390                 395                 400 


Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys 
                405                 410                 415     


Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys Met 
            420                 425                 430         


His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn 
        435                 440                 445             


Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe Asp 
    450                 455                 460                 


Val 
465 


<210>  7
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  8
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  9
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
1               5                   10                  15      


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
            20                  25                  30          


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
        35                  40                  45              


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
    50                  55                  60                  


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
65                  70                  75                  80  


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
                85                  90                  95      


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
            100                 105                 110         


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
        115                 120                 125             


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
    130                 135                 140                 


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
145                 150                 155                 160 


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
                165                 170                 175     


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
            180                 185                 190         


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
        195                 200                 205             


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
    210                 215                 220                 


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
225                 230                 235                 240 


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
                245                 250                 255     


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
            260                 265                 270         


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
        275                 280                 285             


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
    290                 295                 300                 


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
305                 310                 315                 320 


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
                325                 330                 335     


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
            340                 345                 350         


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
        355                 360                 365             


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
    370                 375                 380                 


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
385                 390                 395                 400 


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
                405                 410                 415     


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
            420                 425                 430         


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
        435                 440                 445             


Gln 
    


<210>  10
<211>  487
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro 
            100                 105                 110         


Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr 
        115                 120                 125             


Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp Thr 
    130                 135                 140                 


Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln Arg 
145                 150                 155                 160 


Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys 
                165                 170                 175     


Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly 
            180                 185                 190         


Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp 
        195                 200                 205             


Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu Asn 
    210                 215                 220                 


Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly 
225                 230                 235                 240 


Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro 
                245                 250                 255     


Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu Asp 
            260                 265                 270         


Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr Asp 
        275                 280                 285             


Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr Leu 
    290                 295                 300                 


Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg Leu 
305                 310                 315                 320 


Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser Lys 
                325                 330                 335     


Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met Gln 
            340                 345                 350         


Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly Trp 
        355                 360                 365             


Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp Val 
    370                 375                 380                 


Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp Thr 
385                 390                 395                 400 


Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys Phe 
                405                 410                 415     


Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys Asn 
            420                 425                 430         


Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val Val 
        435                 440                 445             


Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys Asp 
    450                 455                 460                 


Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile His 
465                 470                 475                 480 


Thr Tyr Leu Trp Arg Arg Gln 
                485         


<210>  11
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  12
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ala Leu Gly Pro Ser Ser Gln Asn Val Thr Glu Tyr Val Val 
1               5                   10                  15      


Arg Val Pro Lys Asn Thr Thr Lys Lys Tyr Asn Ile Met Ala Phe Asn 
            20                  25                  30          


Ala Ala Asp Lys Val Asn Phe Ala Thr Trp Asn Gln Ala Arg Leu Glu 
        35                  40                  45              


Arg Asp Leu Ser Asn Lys Lys Ile Tyr Gln Glu Glu Glu Met Pro Glu 
    50                  55                  60                  


Ser Gly Ala Gly Ser Glu Phe Asn Arg Lys Leu Arg Glu Glu Ala Arg 
65                  70                  75                  80  


Arg Lys Lys Tyr Gly Ile Val Leu Lys Glu Phe Arg Pro Glu Asp Gln 
                85                  90                  95      


Pro Trp Leu Leu Arg Val Asn Gly Lys Ser Gly Arg Lys Phe Lys Gly 
            100                 105                 110         


Ile Lys Lys Gly Gly Val Thr Glu Asn Thr Ser Tyr Tyr Ile Phe Thr 
        115                 120                 125             


Gln Cys Pro Asp Gly Ala Phe Glu Ala Phe Pro Val His Asn Trp Tyr 
    130                 135                 140                 


Asn Phe Thr Pro Leu Ala Arg His Arg Thr Leu Thr Ala Glu Glu Ala 
145                 150                 155                 160 


Glu Glu Glu Trp Glu Arg Arg Asn Lys Val Leu Asn His Phe Ser Ile 
                165                 170                 175     


Met Gln Gln Arg Arg Leu Lys Asp Gln Asp Gln Asp Glu Asp Glu Glu 
            180                 185                 190         


Glu Lys Glu Lys Arg Gly Arg Arg Lys Ala Ser Glu Leu Arg Ile His 
        195                 200                 205             


Asp Leu Glu Asp Asp Leu Glu Met Ser Ser Asp Ala Ser Asp Ala Ser 
    210                 215                 220                 


Gly Glu Glu Gly Gly Arg Val Pro Lys Ala Lys Lys Lys Ala Pro Leu 
225                 230                 235                 240 


Ala Lys Gly Gly Arg Lys Lys Lys Lys Lys Lys Gly Ser Asp Asp Glu 
                245                 250                 255     


Ala Phe Glu Asp Ser Asp Asp Gly Asp Phe Glu Gly Gln Glu Val Asp 
            260                 265                 270         


Tyr Met Ser Asp Gly Ser Ser Ser Ser Gln Glu Glu Pro Glu Ser Lys 
        275                 280                 285             


Ala Lys Ala Pro Gln Gln Glu Glu Gly Pro Lys Gly Val Asp Glu Gln 
    290                 295                 300                 


Ser Asp Ser Ser Glu Glu Ser Glu Glu Glu Lys Pro Pro Glu Glu Asp 
305                 310                 315                 320 


Lys Glu Glu Glu Glu Glu Lys Lys Ala Pro Thr Pro Gln Glu Lys Lys 
                325                 330                 335     


Arg Arg Lys Asp Ser Ser Glu Glu Ser Asp Ser Ser Glu Glu Ser Asp 
            340                 345                 350         


Ile Asp Ser Glu Ala Ser Ser Ala Phe Phe Met Ala Lys Lys Lys Thr 
        355                 360                 365             


Pro Pro Lys Arg Glu Arg Lys Pro Ser Gly Gly Ser Ser Arg Gly Asn 
    370                 375                 380                 


Ser Arg Pro Gly Thr Pro Ser Ala Glu Gly Gly Ser Thr Ser Ser Thr 
385                 390                 395                 400 


Leu Arg Ala Ala Ala Ser Lys Leu Glu Gln Gly Lys Arg Val Ser Glu 
                405                 410                 415     


Met Pro Ala Ala Lys Arg Leu Arg Leu Asp Thr Gly Pro Gln Ser Leu 
            420                 425                 430         


Ser Gly Lys Ser Thr Pro Gln Pro Pro Ser Gly Lys Thr Thr Pro Asn 
        435                 440                 445             


Ser Gly Asp Val Gln Val Thr Glu Asp Ala Val Arg Arg Tyr Leu Thr 
    450                 455                 460                 


Arg Lys Pro Met Thr Thr Lys Asp Leu Leu Lys Lys Phe Gln Thr Lys 
465                 470                 475                 480 


Lys Thr Gly Leu Ser Ser Glu Gln Thr Val Asn Val Leu Ala Gln Ile 
                485                 490                 495     


Leu Lys Arg Leu Asn Pro Glu Arg Lys Met Ile Asn Asp Lys Met His 
            500                 505                 510         


Phe Ser Leu Lys Glu 
        515         


<210>  13
<211>  3793
<212>  DNA
<213>  Homo sapiens

<400>  13
tctcattaga agtgaggcgg ggccggccaa atcgaatgga caccgggtaa ttagcagggt       60

tacccagata ctccagcacc tctttcccgt cggccgtgta cctgccattc acgtccatgc      120

cattgatggc cagcactgca tgacccactg cagaggtgaa gctaacggtc agcgaaggtg      180

cagcccgggg attccgccga ggggacaagg gacccgacac aacccctttt cccccaaccc      240

cgcacctaca accagcccac ttctacagca ctggggccct cccacccccg cacccgccac      300

gggcccgagc ctagcccacc tcggatgccg tcccgctggc cgaaagcaac caacacacgc      360

tcatcgtgta gcttgagcag cagatccagc ggataactga aagttttctc agcctcagcc      420

cgtggcgcgt agctgtccaa ctggtaaatc aagccgccag ctttgttcac cacatacaca      480

ctaaaaatcg ccatcgctgc cttgccgctc ggaaactggt attcagcctc tacccgacgg      540

cccctccccg gaaccgcatc acagcacttg ccgccggccc caccccagcc tcctcctcct      600

cctcctcctc ctcccgcgcc ccccgtgcag ccacctgctg cacttgcgca ctgggagcga      660

cacgctcggg cataagtagt gccgaaaagt tagctgccga gacctggtgg attgcttttc      720

gtttatcagt gcaggaaaac agcgctatag tactgcgtca caactagcgc agactccggc      780

agtatttagg cggtgcggct tgggaactag aatccacttc ctgtcttccg cctcaggcta      840

gagggcgagc gcttcgccgt gggacttctt ctgcctggct ccgcctcttg ccccggaagt      900

actcacagcg gacggtggtt tttgggcccg tttctgagca gcgcttcctt tttgtccgac      960

atcttgacga ggctgcggtg tctgctgcta ttctccgagc ttcgcaatgg taagcttcag     1020

gggtgtgaag tcgccggcgt tcttgggttt gaggactcag tggggagagc cttcggcggg     1080

agcgctcctt ggcctgccgg cctcggttgc agggcgggcg cggttattgc ttggcccatg     1140

tgctctggtg gtggagtttg cgggggctga gggcgcagta ttaggggact ttggcgctat     1200

ttgaggacct ggttgcattc ccgctgccct cctacagccg cctaaggacg acaagaagaa     1260

gaaggacgct ggaaagtcgg ccaagaaaga caaagaccca gtgaacaaat ccgggggcaa     1320

ggccaaaaag aaggtagaaa taagacctct ctgaaagaga ctaggggtaa ctctctcgta     1380

atcctctagt aataggtaac ttgtatagta agtggttttt caggtgtaga tttctagagt     1440

caaaatgtga gagtttatct tcccgtcacc actcgttctt tttcccatta ggatcatgaa     1500

aatgggtctg ttgtgcgaag tgtctgccgc tgtgcctgct gtgttatttt taactgatct     1560

agtggggctc ggcccctgtt tgaaggccaa aaacgtgtcg gtgttttttt tttgtttttg     1620

ttttagtaat gtgtaattta tccttgataa cggtggaaca gatttctctg acgcagatta     1680

ctcgagaggg aaagggtgct tctgccagaa atactaactt gtttctgttt tgttttggtg     1740

agcagaagtg gtccaaaggc aaagttcggg acaagctcaa taacttagtc ttgtttgaca     1800

aagctaccta tgataaactc tgtaaggaag ttcccaacta taaacttata accccagctg     1860

tggtctctga gagactgaag attcgaggct ccctggccag ggcagccctt caggagctcc     1920

ttagtaaagg tgaggggtgt atcctacatg tgtgtttttg taggttaaat tgtcttgacc     1980

atgttaagca tcttcagtgg ttttgctgga aaagcagaat taaaaaaaaa aagcgtggct     2040

tgaccattgg ctgttagtaa tgtaattctg acgtcttact cctgatcctg agatgaattc     2100

tcagggttct tagccacttt tgtgccgtgg accctgtggc agtttagtga agcccaagga     2160

tcttttatgt ttcgagtaaa tggatgcata gaattacagg gacaaccgtt tttgaaataa     2220

ttagattact attttgaaac aactttgaaa atgtttaaaa cctttatggt aaatattttg     2280

ttgatgtatt aaattttaaa accagaaatt tagtacggtc tactcagtag tatggtctga     2340

ttaccataat tccacaataa taaggctcag ctaactatag tgactgaacg tctataattc     2400

tagcactttg ggaggccaag gcgggtgaat caacggaggt caggagttaa agaccagcct     2460

ggccaatatg gtgaaaacct gctctactga aagttagctg gacgtggggg cacacgtctg     2520

taatcccagc tactcaggat gctgaggcat gaggatccct tgaacccagg agatggaggt     2580

ggcagtgagc cgagatgaca ccactgcact ccagccttag tgacagcaaa agactgtctc     2640

agaaaggggg ggggggtgga agataatgga gccctaattt aaaggaaaag taaggataga     2700

tgatccgtta aaaacttgga ttctcggtta ccgaacgtca gattaagcaa ttctggagcc     2760

aggtgcagtg gtacccttgt atttctagct acttgggagg ccaaagcagg aggatcattt     2820

gagccaagga gttttaagac cattctgggc acctctgaga gaactctgtc tttttgtttt     2880

ccttttcttt aaatagagat gcggttttgc catgttgccc aggctggtct cctgggctca     2940

agagatccac ctgtccaaag tgctgggatt acaggcatga gcctctgcac ccggccaaaa     3000

caaaccttac tagagtctca ttctgttgcc caggttggag tgcggagggg cagtcttggc     3060

tcaatgcaac caccaattcc tgggttcagg tggtcctcac ctcagcttcc caagtagctg     3120

gaattacaag catgtgccac catgcccagc taatttttgt atttttggta gagatggggt     3180

ttcaccttgt tggccaggct ggtgtgcaac tccttacctc aagctatctg cccgtctcca     3240

cctcccaaag cagtgggatt ataagcatga gccaccgcgc ccagccaaaa accttactag     3300

tttctattgt agcatctgtt aagcatctca tcgtgctatt ctctccccct aggacttatc     3360

aaactggttt caaagcacag agctcaagta atttacacca gaaataccaa gggtggagat     3420

gctccagctg ctggtgaaga tgcatgaata ggtgagtagg aatgtgtggg ctcatggtgt     3480

aggaggtaga tacaaagctt tatggttctg attcttttaa ttttttttta caggtccaac     3540

cagctgtaca tttggaaaaa taaaacttta ttaaatcaaa tgaatgagta tgtctgtttc     3600

ctaagaaaga caatgataaa gaatttggtg gaaggtataa taggggtttg ttgactttgc     3660

ttttagcctc atggtagttg gtagagagca tgattagctt ttttctgtat gtgactgctt     3720

cttcattgct gcagcttcag ttttgaattg atgtctgaaa ggaaataaag ggttaacacg     3780

atgatgaagg gtg                                                        3793


<210>  14
<211>  6762
<212>  DNA
<213>  Homo sapiens

<400>  14
ggacggccga gcggcagggc gctcgcgcgc gcccactagt ggccggagga gaaggctccc       60

gcggaggccg cgctgcccgc cccctcccct ggggaggctc gcgttcccgc tgctcgcgcc      120

tgcgccgccc gccggcctca ggaacgcgcc ctcttcgccg gcgcgcgccc tcgcagtcac      180

cgccacccac cagctccggc accaacagca gcgccgctgc caccgcccac cttctgccgc      240

cgccaccaca gccaccttct cctcctccgc tgtcctctcc cgtcctcgcc tctgtcgact      300

atcaggtgaa ctttgaacca ggatggctga gccccgccag gagttcgaag tgatggaaga      360

tcacgctggg acgtacgggt tgggggacag gaaagatcag gggggctaca ccatgcacca      420

agaccaagag ggtgacacgg acgctggcct gaaagaatct cccctgcaga cccccactga      480

ggacggatct gaggaaccgg gctctgaaac ctctgatgct aagagcactc caacagcgga      540

agatgtgaca gcacccttag tggatgaggg agctcccggc aagcaggctg ccgcgcagcc      600

ccacacggag atcccagaag gaaccacagc tgaagaagca ggcattggag acacccccag      660

cctggaagac gaagctgctg gtcacgtgac ccaagagcct gaaagtggta aggtggtcca      720

ggaaggcttc ctccgagagc caggcccccc aggtctgagc caccagctca tgtccggcat      780

gcctggggct cccctcctgc ctgagggccc cagagaggcc acacgccaac cttcggggac      840

aggacctgag gacacagagg gcggccgcca cgcccctgag ctgctcaagc accagcttct      900

aggagacctg caccaggagg ggccgccgct gaagggggca gggggcaaag agaggccggg      960

gagcaaggag gaggtggatg aagaccgcga cgtcgatgag tcctcccccc aagactcccc     1020

tccctccaag gcctccccag cccaagatgg gcggcctccc cagacagccg ccagagaagc     1080

caccagcatc ccaggcttcc cagcggaggg tgccatcccc ctccctgtgg atttcctctc     1140

caaagtttcc acagagatcc cagcctcaga gcccgacggg cccagtgtag ggcgggccaa     1200

agggcaggat gcccccctgg agttcacgtt tcacgtggaa atcacaccca acgtgcagaa     1260

ggagcaggcg cactcggagg agcatttggg aagggctgca tttccagggg cccctggaga     1320

ggggccagag gcccggggcc cctctttggg agaggacaca aaagaggctg accttccaga     1380

gccctctgaa aagcagcctg ctgctgctcc gcgggggaag cccgtcagcc gggtccctca     1440

actcaaagct cgcatggtca gtaaaagcaa agacgggact ggaagcgatg acaaaaaagc     1500

caagacatcc acacgttcct ctgctaaaac cttgaaaaat aggccttgcc ttagccccaa     1560

acaccccact cctggtagct cagaccctct gatccaaccc tccagccctg ctgtgtgccc     1620

agagccacct tcctctccta aatacgtctc ttctgtcact tcccgaactg gcagttctgg     1680

agcaaaggag atgaaactca agggggctga tggtaaaacg aagatcgcca caccgcgggg     1740

agcagcccct ccaggccaga agggccaggc caacgccacc aggattccag caaaaacccc     1800

gcccgctcca aagacaccac ccagctctgg tgaacctcca aaatcagggg atcgcagcgg     1860

ctacagcagc cccggctccc caggcactcc cggcagccgc tcccgcaccc cgtcccttcc     1920

aaccccaccc acccgggagc ccaagaaggt ggcagtggtc cgtactccac ccaagtcgcc     1980

gtcttccgcc aagagccgcc tgcagacagc ccccgtgccc atgccagacc tgaagaatgt     2040

caagtccaag atcggctcca ctgagaacct gaagcaccag ccgggaggcg ggaaggtgca     2100

gataattaat aagaagctgg atcttagcaa cgtccagtcc aagtgtggct caaaggataa     2160

tatcaaacac gtcccgggag gcggcagtgt gcaaatagtc tacaaaccag ttgacctgag     2220

caaggtgacc tccaagtgtg gctcattagg caacatccat cataaaccag gaggtggcca     2280

ggtggaagta aaatctgaga agcttgactt caaggacaga gtccagtcga agattgggtc     2340

cctggacaat atcacccacg tccctggcgg aggaaataaa aagattgaaa cccacaagct     2400

gaccttccgc gagaacgcca aagccaagac agaccacggg gcggagatcg tgtacaagtc     2460

gccagtggtg tctggggaca cgtctccacg gcatctcagc aatgtctcct ccaccggcag     2520

catcgacatg gtagactcgc cccagctcgc cacgctagct gacgaggtgt ctgcctccct     2580

ggccaagcag ggtttgtgat caggcccctg gggcggtcaa taattgtgga gaggagagaa     2640

tgagagagtg tggaaaaaaa aagaataatg acccggcccc cgccctctgc ccccagctgc     2700

tcctcgcagt tcggttaatt ggttaatcac ttaacctgct tttgtcactc ggctttggct     2760

cgggacttca aaatcagtga tgggagtaag agcaaatttc atctttccaa attgatgggt     2820

gggctagtaa taaaatattt aaaaaaaaac attcaaaaac atggccacat ccaacatttc     2880

ctcaggcaat tccttttgat tcttttttct tccccctcca tgtagaagag ggagaaggag     2940

aggctctgaa agctgcttct gggggatttc aagggactgg gggtgccaac cacctctggc     3000

cctgttgtgg gggtgtcaca gaggcagtgg cagcaacaaa ggatttgaaa cttggtgtgt     3060

tcgtggagcc acaggcagac gatgtcaacc ttgtgtgagt gtgacggggg ttggggtggg     3120

gcgggaggcc acgggggagg ccgaggcagg ggctgggcag aggggagagg aagcacaaga     3180

agtgggagtg ggagaggaag ccacgtgctg gagagtagac atccccctcc ttgccgctgg     3240

gagagccaag gcctatgcca cctgcagcgt ctgagcggcc gcctgtcctt ggtggccggg     3300

ggtgggggcc tgctgtgggt cagtgtgcca ccctctgcag ggcagcctgt gggagaaggg     3360

acagcgggta aaaagagaag gcaagctggc aggagggtgg cacttcgtgg atgacctcct     3420

tagaaaagac tgaccttgat gtcttgagag cgctggcctc ttcctccctc cctgcagggt     3480

agggggcctg agttgagggg cttccctctg ctccacagaa accctgtttt attgagttct     3540

gaaggttgga actgctgcca tgattttggc cactttgcag acctgggact ttagggctaa     3600

ccagttctct ttgtaaggac ttgtgcctct tgggagacgt ccacccgttt ccaagcctgg     3660

gccactggca tctctggagt gtgtgggggt ctgggaggca ggtcccgagc cccctgtcct     3720

tcccacggcc actgcagtca ccccgtctgc gccgctgtgc tgttgtctgc cgtgagagcc     3780

caatcactgc ctatacccct catcacacgt cacaatgtcc cgaattccca gcctcaccac     3840

cccttctcag taatgaccct ggttggttgc aggaggtacc tactccatac tgagggtgaa     3900

attaagggaa ggcaaagtcc aggcacaaga gtgggacccc agcctctcac tctcagttcc     3960

actcatccaa ctgggaccct caccacgaat ctcatgatct gattcggttc cctgtctcct     4020

cctcccgtca cagatgtgag ccagggcact gctcagctgt gaccctaggt gtttctgcct     4080

tgttgacatg gagagagccc tttcccctga gaaggcctgg ccccttcctg tgctgagccc     4140

acagcagcag gctgggtgtc ttggttgtca gtggtggcac caggatggaa gggcaaggca     4200

cccagggcag gcccacagtc ccgctgtccc ccacttgcac cctagcttgt agctgccaac     4260

ctcccagaca gcccagcccg ctgctcagct ccacatgcat agtatcagcc ctccacaccc     4320

gacaaagggg aacacacccc cttggaaatg gttcttttcc cccagtccca gctggaagcc     4380

atgctgtctg ttctgctgga gcagctgaac atatacatag atgttgccct gccctcccca     4440

tctgcaccct gttgagttgt agttggattt gtctgtttat gcttggattc accagagtga     4500

ctatgatagt gaaaagaaaa aaaaaaaaaa aaaaggacgc atgtatcttg aaatgcttgt     4560

aaagaggttt ctaacccacc ctcacgaggt gtctctcacc cccacactgg gactcgtgtg     4620

gcctgtgtgg tgccaccctg ctggggcctc ccaagttttg aaaggctttc ctcagcacct     4680

gggacccaac agagaccagc ttctagcagc taaggaggcc gttcagctgt gacgaaggcc     4740

tgaagcacag gattaggact gaagcgatga tgtccccttc cctacttccc cttggggctc     4800

cctgtgtcag ggcacagact aggtcttgtg gctggtctgg cttgcggcgc gaggatggtt     4860

ctctctggtc atagcccgaa gtctcatggc agtcccaaag gaggcttaca actcctgcat     4920

cacaagaaaa aggaagccac tgccagctgg ggggatctgc agctcccaga agctccgtga     4980

gcctcagcca cccctcagac tgggttcctc tccaagctcg ccctctggag gggcagcgca     5040

gcctcccacc aagggccctg cgaccacagc agggattggg atgaattgcc tgtcctggat     5100

ctgctctaga ggcccaagct gcctgcctga ggaaggatga cttgacaagt caggagacac     5160

tgttcccaaa gccttgacca gagcacctca gcccgctgac cttgcacaaa ctccatctgc     5220

tgccatgaga aaagggaagc cgcctttgca aaacattgct gcctaaagaa actcagcagc     5280

ctcaggccca attctgccac ttctggtttg ggtacagtta aaggcaaccc tgagggactt     5340

ggcagtagaa atccagggcc tcccctgggg ctggcagctt cgtgtgcagc tagagcttta     5400

cctgaaagga agtctctggg cccagaactc tccaccaaga gcctccctgc cgttcgctga     5460

gtcccagcaa ttctcctaag ttgaagggat ctgagaagga gaaggaaatg tggggtagat     5520

ttggtggtgg ttagagatat gcccccctca ttactgccaa cagtttcggc tgcatttctt     5580

cacgcacctc ggttcctctt cctgaagttc ttgtgccctg ctcttcagca ccatgggcct     5640

tcttatacgg aaggctctgg gatctccccc ttgtggggca ggctcttggg gccagcctaa     5700

gatcatggtt tagggtgatc agtgctggca gataaattga aaaggcacgc tggcttgtga     5760

tcttaaatga ggacaatccc cccagggctg ggcactcctc ccctcccctc acttctccca     5820

cctgcagagc cagtgtcctt gggtgggcta gataggatat actgtatgcc ggctccttca     5880

agctgctgac tcactttatc aatagttcca tttaaattga cttcagtggt gagactgtat     5940

cctgtttgct attgcttgtt gtgctatggg gggagggggg aggaatgtgt aagatagtta     6000

acatgggcaa agggagatct tggggtgcag cacttaaact gcctcgtaac ccttttcatg     6060

atttcaacca catttgctag agggagggag cagccacgga gttagaggcc cttggggttt     6120

ctcttttcca ctgacaggct ttcccaggca gctggctagt tcattccctc cccagccagg     6180

tgcaggcgta ggaatatgga catctggttg ctttggcctg ctgccctctt tcaggggtcc     6240

taagcccaca atcatgcctc cctaagacct tggcatcctt ccctctaagc cgttggcacc     6300

tctgtgccac ctctcacact ggctccagac acacagcctg tgcttttgga gctgagatca     6360

ctcgcttcac cctcctcatc tttgttctcc aagtaaagcc acgaggtcgg ggcgagggca     6420

gaggtgatca cctgcgtgtc ccatctacag acctgcagct tcataaaact tctgatttct     6480

cttcagcttt gaaaagggtt accctgggca ctggcctaga gcctcacctc ctaatagact     6540

tagccccatg agtttgccat gttgagcagg actatttctg gcacttgcaa gtcccatgat     6600

ttcttcggta attctgaggg tggggggagg gacatgaaat catcttagct tagctttctg     6660

tctgtgaatg tctatatagt gtattgtgtg ttttaacaaa tgatttacac tgactgttgc     6720

tgtaaaagtg aatttggaaa taaagttatt actctgatta aa                        6762


