                         SEQUENCE LISTING

<110>  FundaMental Pharma GmbH
 
<120>  Novel means to predict and manipulate NMDA receptor-mediated 
       toxicity

<130>  FMP-002 PCT

<150>  EP20190722.7
<151>  2020-08-12

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Ser Ile Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  2
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A motif mutated with 2 Ile residues mutated to Ala residues

<400>  2

Phe Ser Ile Ser Arg Gly Ala Tyr Ser Cys Ala His Gly Val His Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  3
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A core motif mutated with 3 Ile residues mutated to Ala 
       residues

<400>  3

Phe Ser Ala Ser Arg Gly Ala Tyr Ser Cys Ala His Gly Val His Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  4
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Ser Ile Ser Arg Gly Met Tyr Ser Cys Ile His Gly Val His Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  5
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Ser Ile Ser Arg Gly Ile Tyr Arg Cys Ile His Gly Val His Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  6
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Homo sapiens

<400>  6

Phe Ser Ile Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Asn 
1               5                   10                  15      


Glu Glu 
        


<210>  7
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Ser Ile Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  8
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Ser Ile Ser Arg Gly Ile Tyr Ser Cys Met His Gly Val Ala Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  9
<211>  33
<212>  PRT
<213>  homo sapiens

<400>  9

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A core motif mutated with 2 Ile residues mutated to Ala 
       residues plus flanking regions

<400>  10

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ala Tyr Ser Cys Ala His Gly Val His Ile Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A core motif mutated with 3 Ile residues mutated to Ala 
       residues plus flanking regions

<400>  11

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ala Ser Arg 
1               5                   10                  15      


Gly Ala Tyr Ser Cys Ala His Gly Val His Ile Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  12
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Met Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  13
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ile Tyr Arg Cys Ile His Gly Val His Ile Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  14
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  14

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ile Tyr Ser Cys Ile His Gly Val His Asn Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  15
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg Gln Ser 
            20                  25                  30          


Val 
    


<210>  16
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ile Tyr Ser Cys Met His Gly Val Ala Ile Glu Glu Arg Gln Ser 
            20                  25                  30          


Val 
    


<210>  17
<211>  29
<212>  PRT
<213>  Unknown

<220>
<223>  Glycosylphosphatidylinositol (GPI) signal anchor sequence

<400>  17

Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val Leu Leu Leu 
1               5                   10                  15      


Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
            20                  25                  


<210>  18
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  C-terminal targeting signal of K-Ras4B

<400>  18

Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys Ser Arg Thr Arg Cys Thr 
1               5                   10                  15      


Val Met 
        


<210>  19
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  19

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  HA tag

<400>  20

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  21
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A motif mutated with 2 Ile residues and one His residue 
       mutated to Ala residues

<400>  21

Phe Ser Ile Ser Arg Gly Ala Tyr Ser Cys Ala His Gly Val Ala Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  22
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  22

Phe Ser Ile Ser Arg Gly Ile Tyr Ser Cys Ile Arg Gly Val Ala Ile 
1               5                   10                  15      


Glu Glu 
        


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A deletion mutant fragment exhibiting only flanking regions

<400>  23

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Lys Lys Lys Ser 
1               5                   10                  15  


<210>  24
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A motif mutated with 2 Ile residues and one His residue 
       mutated to Ala residues plus flanking regions

<400>  24

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ala Tyr Ser Cys Ala His Gly Val Ala Ile Glu Glu Lys Lys Lys 
            20                  25                  30          


Ser 
    


<210>  25
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2B deletion mutant fragment exhibiting only flanking regions

<400>  25

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Arg Gln Ser Val 
1               5                   10                  15  


<210>  26
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2B motif mutated with 2 Ile residues mutated to Ala residues 
       plus flanking regions

<400>  26

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ala Tyr Ser Cys Ala His Gly Val Ala Ile Glu Glu Arg Gln Ser 
            20                  25                  30          


Val 
    


<210>  27
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2B motif mutated with 2 Ile residues mutated to Ala residues 
       and one Ala residue mutated to His plus flanking regions

<400>  27

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ala Tyr Ser Cys Ala His Gly Val His Ile Glu Glu Arg Gln Ser 
            20                  25                  30          


Val 
    


<210>  28
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile Ser Arg 
1               5                   10                  15      


Gly Ile Tyr Ser Cys Ile Arg Gly Val Ala Ile Glu Glu Arg Gln Ser 
            20                  25                  30          


Val 
    


<210>  29
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  29
gggatctgcc acaacgagaa                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  30
ctcccgtttc ctttctgcct                                                   20


<210>  31
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  31
cctatgcttt gcaacttgtc tca                                               23


<210>  32
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  32
ttggatgaag tcagcagctc tt                                                22


<210>  33
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  33
gcgtattcta catgctgg                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  34
cagggctcct gcaagaag                                                     18


<210>  35
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  35
gaagctctct ggctcactgg                                                   20


<210>  36
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Ala Cys Thr Gly Cys Cys Cys Ala Ala Ala Thr Cys Cys Cys Ala 
1               5                   10                  15      


Cys Ala Cys Ala 
            20  


<210>  37
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  37
acctcagctc accacatgac                                                   20


<210>  38
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Ala Thr Gly Ala Cys Thr Cys Cys Cys Gly Thr Cys Gly Gly Ala 
1               5                   10                  15      


Thr Gly Ala Ala 
            20  


<210>  39
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  39
cacaatgaga agaatgagg                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  40
ggtataaatt aggcaaact                                                    19


<210>  41
<211>  1446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2A LACK SEQ ID 1, Q00959, NMDE1_RAT

<400>  41

Met Gly Arg Leu Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Asp Pro Ala Gln Asn Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Leu Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Asn Leu Trp Gly Pro Glu Gln Ala Thr Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser Gln Thr Phe Ile Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Asp Phe Ile Ser Phe Ile Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Leu Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Ala Glu Lys Pro Glu Thr Pro Leu His Thr Leu His Gln 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn Gln Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Arg Phe Asn Gln Arg Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Ser Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Lys Lys Lys Ser 
    850                 855                 860                 


Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys Leu Leu 
865                 870                 875                 880 


Arg Ser Ala Lys Asn Ile Ser Asn Met Ser Asn Met Asn Ser Ser Arg 
                885                 890                 895     


Met Asp Ser Pro Lys Arg Ala Thr Asp Phe Ile Gln Arg Gly Ser Leu 
            900                 905                 910         


Ile Val Asp Met Val Ser Asp Lys Gly Asn Leu Ile Tyr Ser Asp Asn 
        915                 920                 925             


Arg Ser Phe Gln Gly Lys Asp Ser Ile Phe Gly Asp Asn Met Asn Glu 
    930                 935                 940                 


Leu Gln Thr Phe Val Ala Asn Arg His Lys Asp Asn Leu Ser Asn Tyr 
945                 950                 955                 960 


Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn Pro Asn 
                965                 970                 975     


Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Gly Asn Ser Arg Pro 
            980                 985                 990         


Arg Gln Leu Trp Lys Lys Ser Met  Glu Ser Leu Arg Gln  Asp Ser Leu 
        995                 1000                 1005             


Asn Gln  Asn Pro Val Ser Gln  Arg Asp Glu Lys Thr  Ala Glu Asn 
    1010                 1015                 1020             


Arg Thr  His Ser Leu Lys Ser  Pro Arg Tyr Leu Pro  Glu Glu Val 
    1025                 1030                 1035             


Ala His  Ser Asp Ile Ser Glu  Thr Ser Ser Arg Ala  Thr Cys His 
    1040                 1045                 1050             


Arg Glu  Pro Asp Asn Asn Lys  Asn His Lys Thr Lys  Asp Asn Phe 
    1055                 1060                 1065             


Lys Arg  Ser Met Ala Ser Lys  Tyr Pro Lys Asp Cys  Ser Asp Val 
    1070                 1075                 1080             


Asp Arg  Thr Tyr Met Lys Thr  Lys Ala Ser Ser Pro  Arg Asp Lys 
    1085                 1090                 1095             


Ile Tyr  Thr Ile Asp Gly Glu  Lys Glu Pro Ser Phe  His Leu Asp 
    1100                 1105                 1110             


Pro Pro  Gln Phe Val Glu Asn  Ile Thr Leu Pro Glu  Asn Val Gly 
    1115                 1120                 1125             


Phe Pro  Asp Thr Tyr Gln Asp  His Asn Glu Asn Phe  Arg Lys Gly 
    1130                 1135                 1140             


Asp Ser  Thr Leu Pro Met Asn  Arg Asn Pro Leu His  Asn Glu Asp 
    1145                 1150                 1155             


Gly Leu  Pro Asn Asn Asp Gln  Tyr Lys Leu Tyr Ala  Lys His Phe 
    1160                 1165                 1170             


Thr Leu  Lys Asp Lys Gly Ser  Pro His Ser Glu Gly  Ser Asp Arg 
    1175                 1180                 1185             


Tyr Arg  Gln Asn Ser Thr His  Cys Arg Ser Cys Leu  Ser Asn Leu 
    1190                 1195                 1200             


Pro Thr  Tyr Ser Gly His Phe  Thr Met Arg Ser Pro  Phe Lys Cys 
    1205                 1210                 1215             


Asp Ala  Cys Leu Arg Met Gly  Asn Leu Tyr Asp Ile  Asp Glu Asp 
    1220                 1225                 1230             


Gln Met  Leu Gln Glu Thr Gly  Asn Pro Ala Thr Arg  Glu Glu Val 
    1235                 1240                 1245             


Tyr Gln  Gln Asp Trp Ser Gln  Asn Asn Ala Leu Gln  Phe Gln Lys 
    1250                 1255                 1260             


Asn Lys  Leu Arg Ile Asn Arg  Gln His Ser Tyr Asp  Asn Ile Leu 
    1265                 1270                 1275             


Asp Lys  Pro Arg Glu Ile Asp  Leu Ser Arg Pro Ser  Arg Ser Ile 
    1280                 1285                 1290             


Ser Leu  Lys Asp Arg Glu Arg  Leu Leu Glu Gly Asn  Leu Tyr Gly 
    1295                 1300                 1305             


Ser Leu  Phe Ser Val Pro Ser  Ser Lys Leu Leu Gly  Asn Lys Ser 
    1310                 1315                 1320             


Ser Leu  Phe Pro Gln Gly Leu  Glu Asp Ser Lys Arg  Ser Lys Ser 
    1325                 1330                 1335             


Leu Leu  Pro Asp His Ala Ser  Asp Asn Pro Phe Leu  His Thr Tyr 
    1340                 1345                 1350             


Gly Asp  Asp Gln Arg Leu Val  Ile Gly Arg Cys Pro  Ser Asp Pro 
    1355                 1360                 1365             


Tyr Lys  His Ser Leu Pro Ser  Gln Ala Val Asn Asp  Ser Tyr Leu 
    1370                 1375                 1380             


Arg Ser  Ser Leu Arg Ser Thr  Ala Ser Tyr Cys Ser  Arg Asp Ser 
    1385                 1390                 1395             


Arg Gly  His Ser Asp Val Tyr  Ile Ser Glu His Val  Met Pro Tyr 
    1400                 1405                 1410             


Ala Ala  Asn Lys Asn Thr Met  Tyr Ser Thr Pro Arg  Val Leu Asn 
    1415                 1420                 1425             


Ser Cys  Ser Asn Arg Arg Val  Tyr Lys Lys Met Pro  Ser Ile Glu 
    1430                 1435                 1440             


Ser Asp  Val 
    1445     


<210>  42
<211>  1464
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GluN2B LACK SEQ ID 7, Q00960, NMDE2_RAT

<400>  42

Met Lys Pro Ser Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Lys Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ser Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Ile Ser Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Arg Gln Ser 
    850                 855                 860                 


Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser Asn Ile 
865                 870                 875                 880 


Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser Gly Val 
                885                 890                 895     


Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu Ser Ser 
            900                 905                 910         


Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser Asp Cys 
        915                 920                 925             


Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser Asp Tyr 
    930                 935                 940                 


Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys Asp Ser 
945                 950                 955                 960 


Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His Ser Ile 
                965                 970                 975     


Gly Ser Thr Ser Ser Ile Asp Gly Leu Tyr Asp Cys Asp Asn Pro Pro 
            980                 985                 990         


Phe Thr Thr Gln Pro Arg Ser Ile  Ser Lys Lys Pro Leu  Asp Ile Gly 
        995                 1000                 1005             


Leu Pro  Ser Ser Lys His Ser  Gln Leu Ser Asp Leu  Tyr Gly Lys 
    1010                 1015                 1020             


Phe Ser  Phe Lys Ser Asp Arg  Tyr Ser Gly His Asp  Asp Leu Ile 
    1025                 1030                 1035             


Arg Ser  Asp Val Ser Asp Ile  Ser Thr His Thr Val  Thr Tyr Gly 
    1040                 1045                 1050             


Asn Ile  Glu Gly Asn Ala Ala  Lys Arg Arg Lys Gln  Gln Tyr Lys 
    1055                 1060                 1065             


Asp Ser  Leu Lys Lys Arg Pro  Ala Ser Ala Lys Ser  Arg Arg Glu 
    1070                 1075                 1080             


Phe Asp  Glu Ile Glu Leu Ala  Tyr Arg Arg Arg Pro  Pro Arg Ser 
    1085                 1090                 1095             


Pro Asp  His Lys Arg Tyr Phe  Arg Asp Lys Glu Gly  Leu Arg Asp 
    1100                 1105                 1110             


Phe Tyr  Leu Asp Gln Phe Arg  Thr Lys Glu Asn Ser  Pro His Trp 
    1115                 1120                 1125             


Glu His  Val Asp Leu Thr Asp  Ile Tyr Lys Glu Arg  Ser Asp Asp 
    1130                 1135                 1140             


Phe Lys  Arg Asp Ser Val Ser  Gly Gly Gly Pro Cys  Thr Asn Arg 
    1145                 1150                 1155             


Ser His  Leu Lys His Gly Thr  Gly Glu Lys His Gly  Val Val Gly 
    1160                 1165                 1170             


Gly Val  Pro Ala Pro Trp Glu  Lys Asn Leu Thr Asn  Val Asp Trp 
    1175                 1180                 1185             


Glu Asp  Arg Ser Gly Gly Asn  Phe Cys Arg Ser Cys  Pro Ser Lys 
    1190                 1195                 1200             


Leu His  Asn Tyr Ser Ser Thr  Val Ala Gly Gln Asn  Ser Gly Arg 
    1205                 1210                 1215             


Gln Ala  Cys Ile Arg Cys Glu  Ala Cys Lys Lys Ala  Gly Asn Leu 
    1220                 1225                 1230             


Tyr Asp  Ile Ser Glu Asp Asn  Ser Leu Gln Glu Leu  Asp Gln Pro 
    1235                 1240                 1245             


Ala Ala  Pro Val Ala Val Thr  Ser Asn Ala Ser Ser  Thr Lys Tyr 
    1250                 1255                 1260             


Pro Gln  Ser Pro Thr Asn Ser  Lys Ala Gln Lys Lys  Asn Arg Asn 
    1265                 1270                 1275             


Lys Leu  Arg Arg Gln His Ser  Tyr Asp Thr Phe Val  Asp Leu Gln 
    1280                 1285                 1290             


Lys Glu  Glu Ala Ala Leu Ala  Pro Arg Ser Val Ser  Leu Lys Asp 
    1295                 1300                 1305             


Lys Gly  Arg Phe Met Asp Gly  Ser Pro Tyr Ala His  Met Phe Glu 
    1310                 1315                 1320             


Met Pro  Ala Gly Glu Ser Ser  Phe Ala Asn Lys Ser  Ser Val Pro 
    1325                 1330                 1335             


Thr Ala  Gly His His His Asn  Asn Pro Gly Ser Gly  Tyr Met Leu 
    1340                 1345                 1350             


Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr Gln Asn  Pro Phe Ile 
    1355                 1360                 1365             


Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu His Gly  Ser Lys Ser 
    1370                 1375                 1380             


Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly Ala Ser  Lys Thr Arg 
    1385                 1390                 1395             


Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys Pro Val  Val Val Thr 
    1400                 1405                 1410             


Leu His  Gly Ala Val Pro Gly  Arg Phe Gln Lys Asp  Ile Cys Ile 
    1415                 1420                 1425             


Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn Asn Lys  Asn Pro Arg 
    1430                 1435                 1440             


Ala Phe  Asn Gly Ser Ser Asn  Gly His Val Tyr Glu  Lys Leu Ser 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210>  43
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  43

Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser Arg 
1               5                   10                  15      


<210>  44
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys Lys 
1               5                   10                  15      


Ser 
    


<210>  45
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile Ser Arg 
1               5                   10                  15      


<210>  46
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg Gln Ser 
1               5                   10                  15      


Val 
    


<210>  47
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2AdeltaSEQ ID NO:1 forward primer

<400>  47
ccgggctgct ccacattgaa gaaaagaaga                                        30


<210>  48
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2AdeltaSEQ ID NO:1 reverse primer

<400>  48
tcttcaatgt ggagcagccc gggccggtca                                        30


<210>  49
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  GRIN2AdeltaC9 forward primer

<400>  49
cgctaaagag tcctaggtat ct                                                22


<210>  50
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2AdeltaC9 reverse primer

<400>  50
gtctgctcga agcggccgct tacttgtaca ctcgtctatt g                           41


<210>  51
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I2A2 forward primer

<400>  51
ctccatcagc aggggcgcct atagttgcgc ccatgg                                 36


<210>  52
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I2A2 reverse primer

<400>  52
ccatgggcgc aactataggc gcccctgctg atggag                                 36


<210>  53
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I3A3 forward primer

<400>  53
ggctgctctt ctccgccagc aggggcgcct at                                     32


<210>  54
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  GRIN2A-I3A3 reverse primer

<400>  54
ataggcgccc ctgctggcgg agaagagcag cc                                     32


<210>  55
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I2A2HA forward primer

<400>  55
tgcgcccatg gggtagccat tgaagaaaag                                        30


<210>  56
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I2A2HA reverse primer

<400>  56
cttttcttca atggctaccc catgggcgca                                        30


<210>  57
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I867M forward primer

<400>  57
catcagcagg ggcatgtata gttgcatcca t                                      31


<210>  58
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I867M reverse primer

<400>  58
atggatgcaa ctatacatgc ccctgctgat g                                      31


<210>  59
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-S869R forward primer

<400>  59
ggcatctata gatgcatcca tgg                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-S869R reverse primer

<400>  60
ccatggatgc atctatagat gcc                                               23


<210>  61
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I876N forward primer

<400>  61
catccatggg gtacacaatg aagaa                                             25


<210>  62
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2A-I876N reverse primer

<400>  62
ttcttcattg tgtaccccat ggatg                                             25


<210>  63
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2BdeltaSEQ ID NO:7 forward primer

<400>  63
tggcatggtc gccatagagg agcgcca                                           27


<210>  64
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2BdeltaSEQ ID NO:7 reverse primer

<400>  64
cctctatggc gaccatgcca ggcttgcca                                         29


<210>  65
<211>  23
<212>  DNA
<213>  Artificial seqeunce

<220>
<223>  GRIN2BdeltaC9 forward primer

<400>  65
gtggattggg aggaccggtc tgg                                               23


<210>  66
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2BdeltaC9 reverse primer

<400>  66
ggcaagaatt ctcactcata aacatgtcca ttg                                    33


<210>  67
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-I2A2 forward primer

<400>  67
ctccatcagc agaggtgcct acagctgtgc ccatgg                                 36


<210>  68
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-I2A2 reverse primer

<400>  68
ccatgggcac agctgtaggc acctctgctg atggag                                 36


<210>  69
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-I2A2AH forward primer

<400>  69
tgtgcccatg gggtacacat agaggagcgc c                                      31


<210>  70
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-I2A2AH reverse primer

<400>  70
ggcgctcctc tatgtgtacc ccatgggcac a                                      31


<210>  71
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-I872M forward primer

<400>  71
atctacagct gtatgcatgg ggtagcc                                           27


<210>  72
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-I872M reverse primer

<400>  72
ggctacccca tgcatacagc tgtagat                                           27


<210>  73
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-H873R forward primer

<400>  73
ctacagctgt atccgtgggg tagccataga                                        30


<210>  74
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GRIN2B-H873R reverse primer

<400>  74
tctatggcta ccccacggat acagctgtag                                        30


