                         SEQUENCE LISTING

<110>  UNIVERSITY OF OSLO
       UNIVERSITY OF HELSINKI
 
<120>  IMPROVED GENE EDITING

<130>  INVEN-38443.601

<150>  US 63/064,047
<151>  2020-08-11

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (9)..(22)
<223>  N is A, G, T, or C

<400>  1

Met Met Met Met Met Met Met Met Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Xaa Gly Gly 
            20              


<210>  2
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(12)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Xaa Gly Gly 
1               5                   10                  15  


<210>  3
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (10)..(20)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Met Met Met Met Met Met Met Met Met Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Xaa Gly Gly 
            20              


<210>  4
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(11)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Xaa Gly Gly 
1               5                   10                  


<210>  5
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (9)..(20)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  w
<222>  (27)..(27)
<223>  W is A or T

<400>  5

Met Met Met Met Met Met Met Met Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Xaa Xaa Ala Gly Ala Ala Trp 
            20                  25          


<210>  6
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(12)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  w
<222>  (19)..(19)
<223>  W is A or T

<400>  6

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Xaa Xaa Ala Gly 
1               5                   10                  15      


Ala Ala Trp 
            


<210>  7
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (10)..(20)
<223>  N is A, G, T

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  w
<222>  (27)..(27)
<223>  W is A or T

<400>  7

Met Met Met Met Met Met Met Met Met Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Xaa Xaa Ala Gly Ala Ala Trp 
            20                  25          


<210>  8
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(11)
<223>  N is A, G, T

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  w
<222>  (18)..(18)
<223>  W is A or T

<400>  8

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Xaa Xaa Ala Gly Ala 
1               5                   10                  15      


Ala Trp 
        


<210>  9
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (9)..(20)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Met Met Met Met Met Met Met Met Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Xaa Gly Gly Xaa Gly 
            20                  25  


<210>  10
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(12)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Xaa Gly Gly Xaa 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (10)..(20)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Met Met Met Met Met Met Met Met Met Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Xaa Gly Gly Xaa Gly 
            20                  25  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(11)
<223>  N is A, G, T, or C

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Xaa Gly Gly Xaa Gly 
1               5                   10                  15      


<210>  13
<211>  137
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(20)
<223>  N represents a base of a guide sequence

<400>  13

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Gly Thr Thr Thr Thr Thr Gly Thr Ala Cys Thr Cys 
            20                  25                  30          


Thr Cys Ala Ala Gly Ala Thr Thr Thr Ala Gly Ala Ala Ala Thr Ala 
        35                  40                  45              


Ala Ala Thr Cys Thr Thr Gly Cys Ala Gly Ala Ala Gly Cys Thr Ala 
    50                  55                  60                  


Cys Ala Ala Ala Gly Ala Thr Ala Ala Gly Gly Cys Thr Thr Cys Ala 
65                  70                  75                  80  


Thr Gly Cys Cys Gly Ala Ala Ala Thr Cys Ala Ala Cys Ala Cys Cys 
                85                  90                  95      


Cys Thr Gly Thr Cys Ala Thr Thr Thr Thr Ala Thr Gly Gly Cys Ala 
            100                 105                 110         


Gly Gly Gly Thr Gly Thr Thr Thr Thr Cys Gly Thr Thr Ala Thr Thr 
        115                 120                 125             


Thr Ala Ala Thr Thr Thr Thr Thr Thr 
    130                 135         


<210>  14
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(20)
<223>  N represents a base of a guide sequence

<400>  14

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Gly Thr Thr Thr Thr Thr Gly Thr Ala Cys Thr Cys 
            20                  25                  30          


Thr Cys Ala Gly Ala Ala Ala Thr Gly Cys Ala Gly Ala Ala Gly Cys 
        35                  40                  45              


Thr Ala Cys Ala Ala Ala Gly Ala Thr Ala Ala Gly Gly Cys Thr Thr 
    50                  55                  60                  


Cys Ala Thr Gly Cys Cys Gly Ala Ala Ala Thr Cys Ala Ala Cys Ala 
65                  70                  75                  80  


Cys Cys Cys Thr Gly Thr Cys Ala Thr Thr Thr Thr Ala Thr Gly Gly 
                85                  90                  95      


Cys Ala Gly Gly Gly Thr Gly Thr Thr Thr Thr Cys Gly Thr Thr Ala 
            100                 105                 110         


Thr Thr Thr Ala Ala Thr Thr Thr Thr Thr Thr 
        115                 120             


<210>  15
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(20)
<223>  N represents a base of a guide sequence

<400>  15

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Gly Thr Thr Thr Thr Thr Gly Thr Ala Cys Thr Cys 
            20                  25                  30          


Thr Cys Ala Gly Ala Ala Ala Thr Gly Cys Ala Gly Ala Ala Gly Cys 
        35                  40                  45              


Thr Ala Cys Ala Ala Ala Gly Ala Thr Ala Ala Gly Gly Cys Thr Thr 
    50                  55                  60                  


Cys Ala Thr Gly Cys Cys Gly Ala Ala Ala Thr Cys Ala Ala Cys Ala 
65                  70                  75                  80  


Cys Cys Cys Thr Gly Thr Cys Ala Thr Thr Thr Thr Ala Thr Gly Gly 
                85                  90                  95      


Cys Ala Gly Gly Gly Thr Gly Thr Thr Thr Thr Thr Thr Thr 
            100                 105                 110 


<210>  16
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(20)
<223>  N represents a base of a guide sequence

<400>  16

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Gly Thr Thr Thr Thr Thr Gly Thr Ala Cys Thr Cys 
            20                  25                  30          


Thr Cys Ala Gly Ala Ala Ala Thr Ala Gly Cys Ala Ala Gly Thr Thr 
        35                  40                  45              


Ala Ala Ala Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly Thr Cys Cys 
    50                  55                  60                  


Gly Thr Thr Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Gly Thr Cys Gly Gly 
                85                  90                  95      


Thr Gly Cys Thr Thr Thr Thr Thr Thr 
            100                 105 


<210>  17
<211>  88
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(20)
<223>  N represents a base of a guide sequence

<400>  17

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Gly Thr Thr Thr Thr Ala Gly Ala Gly Cys Thr Ala 
            20                  25                  30          


Gly Ala Ala Ala Thr Ala Gly Cys Ala Ala Gly Thr Thr Ala Ala Ala 
        35                  40                  45              


Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly Thr Cys Cys Gly Thr Thr 
    50                  55                  60                  


Ala Thr Cys Ala Ala Cys Thr Thr Gly Ala Ala Ala Ala Ala Gly Thr 
65                  70                  75                  80  


Gly Thr Thr Thr Thr Thr Thr Thr 
                85              


<210>  18
<211>  76
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic


<220>
<221>  n
<222>  (1)..(20)
<223>  N represents a base of a guide sequence

<400>  18

Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Gly Thr Thr Thr Thr Ala Gly Ala Gly Cys Thr Ala 
            20                  25                  30          


Gly Ala Ala Ala Thr Ala Gly Cys Ala Ala Gly Thr Thr Ala Ala Ala 
        35                  40                  45              


Ala Thr Ala Ala Gly Gly Cys Thr Ala Gly Thr Cys Cys Gly Cys Thr 
    50                  55                  60                  


Ala Thr Cys Ala Thr Thr Thr Thr Thr Thr Thr Thr 
65                  70                  75      


<210>  19
<211>  143
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  19

Asp Val Asn Gly Val Thr Tyr Tyr Ile Asn Ile Val Glu Thr Asn Asp 
1               5                   10                  15      


Ile Asp Asp Leu Glu Ile Ala Thr Asp Glu Asp Glu Met Lys Ser Gly 
            20                  25                  30          


Asn Gln Glu Ile Ile Leu Lys Ser Glu Leu Lys Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Ser Pro Ala Arg Pro Ala Leu Arg Ala Pro Ala 
    50                  55                  60                  


Ser Ala Thr Ser Gly Ser Arg Lys Arg Ala Arg Pro Pro Ala Ala Pro 
65                  70                  75                  80  


Gly Arg Asp Gln Ala Arg Pro Pro Ala Arg Arg Arg Leu Arg Leu Ser 
                85                  90                  95      


Val Asp Glu Val Ser Ser Pro Ser Thr Pro Glu Ala Pro Asp Ile Pro 
            100                 105                 110         


Ala Cys Pro Ser Pro Gly Gln Lys Ile Lys Lys Ser Thr Pro Ala Ala 
        115                 120                 125             


Gly Gln Pro Pro His Leu Thr Ser Ala Gln Asp Gln Asp Thr Ile 
    130                 135                 140             


<210>  20
<211>  428
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  20
atgttaatgg cgtgacctac tatattaaca tcgtggaaac caacgatatc gacgatctgg       60

aaattgcaac cgatgaagat gaaatgaaaa gcggcaacca agagattatc ctgaaaagcg      120

aactgaaagg tggtggtggt agcggtggtg gcggttcatc accggcacgt ccggcactgc      180

gtgcaccggc aagtgcaacc agcggtagcc gtaaacgtgc ccgtccgcct gcagcaccgg      240

gtcgtgatca agcacgtccg ccagcacgtc gtcgtctgcg tctgagcgtt gatgaagtta      300

gcagcccgag tacaccggaa gcaccggata ttccggcatg tccgagtccg ggtcagaaaa      360

tcaaaaaatc aacaccggca gcaggtcagc ctccgcatct gaccagcgca caggatcagg      420

atacaatt                                                               428


<210>  21
<211>  4234
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  21
atgaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa ggacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggcaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctgg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccacat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acagcgctgg aggaggtgga agcggaggag gaggaagcgg aggaggaggt     4200

agcggaccta agaaaaagag gaaggtggga attc                                 4234


<210>  22
<211>  491
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  22
ttgatctaga gggcccgcgg ggaggaggtg gaagcggagg aggaggaagc ggaggaggag       60

gtagcagcgc tgcttcaaac tttactcagt tcgtgctcgt ggacaatggt gggacagggg      120

atgtgacagt ggctccttct aatttcgcta atggggtggc agagtggatc agctccaact      180

cacggagcca ggcctacaag gtgacatgca gcgtcaggca gtctagtgcc cagaagagaa      240

agtataccat caaggtggag gtccccaaag tggctaccca gacagtgggc ggagtcgaac      300

tgcctgtcgc cgcttggagg tcctacctga acatggagct cactatccca attttcgcta      360

ccaattctga ctgtgaactc atcgtgaagg caatgcaggg gctcctcaaa gacggtaatc      420

ctatcccttc cgccatcgcc gctaactcag gtatctacgg acctaagaaa aagaggaagg      480

tggcggccgc t                                                           491


<210>  23
<211>  6660
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  23
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca      240

ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc      300

caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta      360

agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa      420

aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc      480

ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc      540

ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg      600

tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc      660

aaaacaaaag taagaccacc gcacagcaag cggccgctga tcttcagacc tggaggagga      720

gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca      780

ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg      840

ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg      900

tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac      960

aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc     1020

aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg     1080

gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt     1140

tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga     1200

gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa     1260

gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt     1320

aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta     1380

ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca     1440

ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata     1500

gaagaagaag gtggagagag agacagagac agatccattc gattagtgaa cggatcggca     1560

ctgcgtgcgc caattctgca gacaaatggc agtattcatc cacaatttta aaagaaaagg     1620

ggggattggg gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca     1680

aactaaagaa ttacaaaaac aaattacaaa aattcaaaat tttcgggttt attacaggga     1740

cagcagagat ccagtttggt taattagcta gcgagggcct atttcccatg attccttcat     1800

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     1860

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     1920

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     1980

atttcttggc tttatatatc ttgtggaaag gacgaaacac cggagacggg ataccgtctc     2040

tgttttagag ctaggccaac atgaggatca cccatgtctg cagggcctag caagttaaaa     2100

taaggctagt ccgttatcaa cttggccaac atgaggatca cccatgtctg cagggccaag     2160

tggcaccgag tcggtgcttt ttttggatcc tgcaaagatg gataaagttt taaacagaga     2220

ggaatctttg cagctaatgg accttctagg tcttgaaagg agtgggaatt ggctccggtg     2280

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2340

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2400

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2460

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc gtgtgtggtt     2520

cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt acttccactg     2580

gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag     2640

gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg     2700

gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc     2760

tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct     2820

tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga     2880

cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc     2940

gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc     3000

gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc     3060

ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc     3120

gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt     3180

cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt agttctcgag     3240

cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca     3300

cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga     3360

atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag     3420

tttttttctt ccatttcagg tgtcgtgatg tacatgccac catggccaag ttgaccagtg     3480

ccgttccggt gctcaccgcg cgcgacgtcg ccggagcggt cgagttctgg accgaccggc     3540

tcgggttctc ccgggacttc gtggaggacg acttcgccgg tgtggtccgg gacgacgtga     3600

ccctgttcat cagcgcggtc caggaccagg tggtgccgga caacaccctg gcctgggtgt     3660

gggtgcgcgg cctggacgag ctgtacgccg agtggtcgga ggtcgtgtcc acgaacttcc     3720

gggacgcctc cgggccggcc atgaccgaga tcggcgagca gccgtggggg cgggagttcg     3780

ccctgcgcga cccggccggc aactgcgtgc acttcgtggc cgaggagcag gacggaggag     3840

gtggaagcgg aggaggagga agcgtgagca agggcgagga actgttcacc ggcgtggtgc     3900

ccatcctggt ggaactggat ggcgacgtga acggccacaa gttcagcgtg tccggcgagg     3960

gcgaaggcga cgccgccgct gccaagctga ccctgaagtt catctgcacc accggcaagc     4020

tgcccgtgcc ttggcctacc ctcgtgacca cctttaccta cggcgtgcag tgcttcgcca     4080

gataccccga ccatatgaag cagcacgact tcttcaagag cgccatgccc gagggctacg     4140

tgcaggaacg gaccatcttc tttaaggacg acggcaacta caagaccagg gccgaagtga     4200

agttcgaggg cgacaccctc gtgaaccgga tcgagctgaa gggcatcgac ttcaaagagg     4260

acggcaacat cctgggccac aagctggagt acaactacaa cagccacaag gtctacatca     4320

ccgccgacaa gcagaaaaac ggcatcaaag tgaacttcaa gacccggcac aacatcgagg     4380

acggctccgt gcagctggcc gaccactacc agcagaacac ccccatcgga gatggccccg     4440

tgctgctgcc cgacaaccac tacctgagca cccagagcaa gctgagcaag gaccccaacg     4500

agaagcggga ccacatggtg ctgctggaat ttgtgaccgc cgctggcatc accctgggca     4560

tggacgagct ctacaaggga tccggcgcaa caaacttctc tctgctgaaa caagccggag     4620

atgtcgaaga gaatcctgga ccgagcgagc tgattaagga gaacatgcac atgaagctct     4680

acatggaggg caccgtggac aaccatcact tcaagtgcac atccgagggc gaaggcaagc     4740

cctacgaggg cacccagacc atgagaatca aggtggtcga gggcggccct ctccccttcg     4800

ccttcgacat cctggctact agcttcctct acggcagcaa gaccttcatc aaccacaccc     4860

agggcatccc cgacttcttc aagcagtcct tccctgaggg cttcacatgg gagagagtca     4920

ccacatacga agacgggggc gtgctgaccg ctacccagga caccagcctc caggacggct     4980

gcctcatcta caacgtcaag atcagagggg tgaacttcac atccaacggc cctgtgatgc     5040

agaagaaaac actcggctgg gaggccttca ccgaaacgct gtaccccgct gacggcggcc     5100

tggaaggcag aaacgacatg gccctgaagc tcgtgggcgg gagccatctg atcgcaaaca     5160

tcaagaccac atatagatcc aagaaacccg ctaagaacct caagatgcct ggcgtctact     5220

atgtggacta cagactggaa agaatcaagg aggccaacaa cgagacctac gtcgagcagc     5280

acgaggtggc agtggccaga tactgcgacc tccctagcaa actggggcac aagcttaatt     5340

gagaattcga tatcaagctt atcggtaatc aacctctgga ttacaaaatt tgtgaaagat     5400

tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc     5460

ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct     5520

ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca     5580

ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt     5640

ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg     5700

cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga     5760

aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt     5820

ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc     5880

cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt     5940

gggccgcctc cccgcatcga taccgtcgac ctcgagacct agaaaaacat ggagcaatca     6000

caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca caagaggagg     6060

aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact tacaaggcag     6120

ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc     6180

aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac ttccctgatt     6240

ggcagaacta cacaccaggg ccagggatca gatatccact gacctttgga tggtgctaca     6300

agctagtacc agttgagcaa gagaaggtag aagaagccaa tgaaggagag aacacccgct     6360

tgttacaccc tgtgagcctg catgggatgg atgacccgga gagagaagta ttagagtgga     6420

ggtttgacag ccgcctagca tttcatcaca tggcccgaga gctgcatccg gactgtactg     6480

ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac     6540

tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt     6600

gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca     6660


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  24
ctgccaagct gaccctgaag                                                   20


<210>  25
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  25
gaacggccac aagttcagcg tgtccggcga gggcgaaggc gacgccacat atggcaagct       60

gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg                            100


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  26
gtagaatgtc aacttcatga                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  27
tactttcgca aacctgaacg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  28
gtcatcttag tcattacctg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  29
ctctgcagaa ttcaaacact                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  30
gagcccataa cctctcgcgg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  31
aagtcctttc atttatcgga                                                   20


<210>  32
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  32
atgtgctaga caatatatta ggtgtgggat acagtgaaat caaatccttg agagtcagaa       60

gttgacattc tactgacaga agacattcaa gcaatacatg                            100


<210>  33
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  33
tgttgagtgt gcctggat                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  34
acccttgcct ctttccct                                                     18


<210>  35
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  35
cttgccctca tgaagttgac attc                                              24


<210>  36
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  36
ccttgagagt cagaagttga cattcta                                           27


<210>  37
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  37
tggaggaccg atcatgtgct agaca                                             25


<210>  38
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  38
tttgctgcaa agcgtctttc cctccgcccc ctctctgggc agcacttatc aacaggtttg       60

cgaaagtaaa gtaagtgtgc cctctactgg cagcagagat                            100


<210>  39
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  39
aggtggctgg aaacttgt                                                     18


<210>  40
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  40
ggagcaacca atcgctatg                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  41
caaacctgaa cgcgggtgc                                                    19


<210>  42
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  42
cgcaaacctg ttgataagtg ctgc                                              24


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  43
cctcggacgc tcctgctcct                                                   20


<210>  44
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  44
taagcaaaac atgggaactc agtttatatg agttacaacg aacacctagt tcggctccta       60

agatgactgc caaggggcat atgagacgtg taaactggga                            100


<210>  45
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  45
cttctttatt tccagcaatg tctc                                              24


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  46
gccaacatac agaagtcagg                                                   20


<210>  47
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  47
acctcaggta atgactaaga tgactgc                                           27


<210>  48
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  48
ctagttcggc tcctaagatg actgc                                             25


<210>  49
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  49
ctgtgcagac aaacggaact caa                                               23


<210>  50
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  50
ccggcagcca gaggcccttt gtgaagggga gctcctccca catataaaca gtttgaattc       60

tgcaatagtt ctgccgttgt tggattcttc catgttcatc                            100


<210>  51
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  51
gctccctcag ggtctgta                                                     18


<210>  52
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  52
cctgtgattc agatcccg                                                     18


<210>  53
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  53
caagtgtttg aattctgcag agaggc                                            26


<210>  54
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  54
tgaattctgc aatagttctg ccgtt                                             25


<210>  55
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  55
aaaggcaggt gtcctgtga                                                    19


<210>  56
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  56
gttttcgaag atgcgctgca cggcgaacac ctgccgggtg ggctcttgat gtgagaggtt       60

atgggctccc aggaccaccc gcaccgcgcg gacgtttctg                            100


<210>  57
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  57
ggatggggac gacaagg                                                      17


<210>  58
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  58
gcacctggag aatcacga                                                     18


<210>  59
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  59
ctcgcggcgg gagc                                                         14


<210>  60
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  60
cataacctct cacatcaaga gccc                                              24


<210>  61
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  61
accccgtaaa cttgctcaac ga                                                22


<210>  62
<211>  103
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  62
gcactctcag gcctcacatg gcagagtatg gttactgctc taaggtatta agataaatcc       60

aaggacttat ttttttgagc ttcagattgg tggcgttatt gca                        103


<210>  63
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  63
tgatgttagt gggagcagg                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  64
cctgtctctc tggaaccac                                                    19


<210>  65
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  65
taagtccttt catttatcgg agggc                                             25


<210>  66
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  66
aataagtcct tggatttatc ttaatacctt                                        30


<210>  67
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  67
accatgggaa gtgaagaaaa gcttc                                             25


