﻿                         序列表

<110>  正大天晴药业集团股份有限公司

<120>  结合BCMA的单可变结构域及抗原结合分子

<160>  36

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  Call001引物序列


<400>  1
gtcctggctg ctcttctaca agg                                                23

<210>  2
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  Call002引物序列


<400>  2
ggtacgtgct gttgaactgt tcc                                                23

<210>  3
<211>  29
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  V-Back引物序列


<400>  3
gatgtgcagc tgcaggagtc tggrggagg                                          29

<210>  4
<211>  34
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  V-Fwd引物序列


<400>  4
ctagtgcggc cgctgaggag acggtgacct gggt                                    34

<210>  5
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  5
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210>  6
<211>  183
<212>  PRT
<213>  食蟹猕猴(Macaca fascicularis)

<400>  6
Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
            20                  25                  30          
Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
        35                  40                  45              
Lys Gly Met Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile 
    50                  55                  60                  
Ile Ser Leu Ala Val Phe Val Leu Thr Phe Leu Leu Arg Lys Met Ser 
65                  70                  75                  80  
Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu 
                85                  90                  95      
Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr Gly Asp Glu Ile 
            100                 105                 110         
Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
        115                 120                 125             
Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 
    130                 135                 140                 
Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
145                 150                 155                 160 
Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser Val Thr Glu Ile 
                165                 170                 175     
Glu Lys Ser Ile Ser Ala Arg 
            180             

<210>  7
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  7
Gly Trp Asn Lys His 
1               5   

<210>  8
<211>  16
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  8
Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  9
<211>  10
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  9
Asp Leu Pro Gly Ser Gly Leu Pro Ala Phe 
1               5                   10  

<210>  10
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  10
Val Ala Cys Met Ala 
1               5   

<210>  11
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  11
Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  12
<211>  14
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  12
Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
1               5                   10                  

<210>  13
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  13
Ser Ala Cys Met Gly 
1               5   

<210>  14
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  14
Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  15
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  15
Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp Tyr Asn 
1               5                   10                  15      
Tyr 
    

<210>  16
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  16
Gly Trp Asn Lys His 
1               5   

<210>  17
<211>  16
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  17
Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  18
<211>  10
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  18
Asp Leu Pro Gly Ser Gly Leu Pro Glu Phe 
1               5                   10  

<210>  19
<211>  118
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  19
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Ala Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  20
<211>  354
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  20
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ccggagggtc tctgagactc        60
tcctgtacag cctctggata caccttcagg ggctggaaca agcactggta ccgccaggct       120
ccagggaagg agcgcgagtt ggtctcgagc atctttcgtg atgggaagac agcctataca       180
gactccgtga agggccgatt caccatctct caagacaacg ccgacgcaac ggtgtatctg       240
caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaaata cgatctgcct       300
ggatctggtc ttcctgcatt ctggggccag gggaccctgg tcactgtctc atca             354

<210>  21
<211>  123
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  21
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  22
<211>  369
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  22
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc gctgagactc        60
tcctgtgccg cctccggata cagcagtaat gtggcatgca tggcctggta ccgccaggct       120
ccagggaagg agcgcgagtg ggtcgcaact attgttgctg atttcggtac cacaaactat       180
gccgcctccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat       240
ctgcaaatga acagcctgaa acctgaggac tctgccatgt actactgtgc ggcaacccag       300
agggggggta ttgactggtg tgatgaaatt aattactggg gccaggggac cctggtcact       360
gtctcatca                                                               369

<210>  23
<211>  126
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  23
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  24
<211>  378
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  24
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc        60
tcctgtgcag cctctggagt cacttttaat agcgcatgta tgggttggtt ccgccaggct       120
ccagggaagg agcgcgaggg ggtcgcacgt attgaaactg gttatggtgg cactgtctat       180
gccgactccg tgaagggacg attcaccatc tcccgagaca acgccaagaa cacggtgtat       240
ctgcaaatga acagcctaaa acctgaggac actgccatgt actactgtgc ggctaagaga       300
tcctggtgta ctcctacgtg gtggcacgaa cttgactata actactgggg acaggggacc       360
caggtcactg tctcatca                                                     378

<210>  25
<211>  118
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<400>  25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Glu Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  26
<211>  354
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<400>  26
gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ccggagggtc tctgagactc        60
tcctgtacag cctctggata caccttcagg ggctggaaca agcactggta ccgccaggct       120
ccagggaagg agcgcgagtt ggtctcgagt atctttcgtg atgggaagac agcctataca       180
gactccgtga agggccgatt caccatctct caagacagcg ccgacgcaac ggtgtatctg       240
caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaaata cgatctgcct       300
ggatctggtc ttcctgagtt ctggggccag gggaccctgg tcactgtctc atca             354

<210>  27
<211>  350
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A1-Fc的全长氨基酸序列


<400>  27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Ala Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 

<210>  28
<211>  1050
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A1-Fc的全长核苷酸序列


<400>  28
caagtgcaac tggtggagtc tggaggcggt tccgtgcagg ccggcggctc cctgagactg        60
tcctgcaccg cttccggcta caccttcaga ggctggaaca agcactggta tcggcaggct       120
cctggcaaag aaagagagct ggtgtcctcc atcttccggg acggcaagac cgcctacacc       180
gactccgtga agggcagatt caccatctct caggacaacg ccgacgccac agtgtacctg       240
cagatgaact ctctgaagcc cgaggacacc gccatgtact actgcaagta cgacctgcct       300
ggatctggcc tgcccgcctt ctggggccaa ggcaccctgg taaccgtgtc gtccgagccc       360
aagtcttgcg acaagaccca cacctgtcct ccttgtcctg ctccggaact gctgggcggc       420
ccttccgtgt ttctgtttcc tccaaagcct aaggacacac tgatgatcag ccggacccct       480
gaggtgacct gcgtggtcgt ggatgtctct cacgaggatc ctgaggtgaa gttcaactgg       540
tacgtggatg gagtggaagt gcataacgct aaaaccaagc ctagagaaga gcagtacaac       600
tccacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa       660
gagtacaagt gcaaggtgtc caacaaggct ctgcctgccc ctatcgagaa gaccatctcc       720
aaggccaagg gccagcctcg ggagcctcaa gtgtacaccc tgcctccttc tcgcgacgag       780
ctgaccaaga accaggtgtc tctgacctgc ctggtgaaag gcttctaccc ctccgacatc       840
gccgtggaat gggagtccaa tggccagccc gagaacaact acaagaccac cccacctgtg       900
ctggactctg atggctcctt cttcctgtac tccaagctga ccgtggacaa gtccagatgg       960
cagcagggca acgtgttctc ctgttctgtg atgcacgagg ccctgcacaa ccactacaca      1020
cagaagtccc tgagcctgtc tcctggcaag                                       1050

<210>  29
<211>  355
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-Fc的全长氨基酸序列


<400>  29
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
        115                 120                 125             
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         
Pro Gly Lys 
        355 

<210>  30
<211>  1065
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-Fc的全长核苷酸序列


<400>  30
caggtgcaac tggtggagtc tggcggcgga tctgtgcaag ctggcggatc cctgagactg        60
tcttgtgccg cttccggcta ctcctctaac gtggcctgta tggcctggta cagacaggcc       120
cctggcaaag aaagagagtg ggtcgccacc atcgtggccg atttcggcac caccaattac       180
gccgcttccg tgaagggcag attcaccatc tctcaggaca acgccaagaa caccgtgtac       240
ctgcagatga actccctgaa gcctgaggac tccgccatgt actactgcgc cgctacacag       300
cgcggaggca ttgattggtg cgacgagatt aactactggg gccaaggcac cctggttacc       360
gtgtcctctg agcccaagtc ctgcgacaag acccacacct gtccaccttg tcctgcccca       420
gaactgctgg gcggtcccag cgtgttcctg ttccccccca agcctaagga cacactgatg       480
atctctagaa cccctgaagt gacctgcgtg gtggtcgatg tatctcacga ggatcctgag       540
gtcaagttca actggtacgt ggacggagtg gaagtgcata atgctaagac caagcctaga       600
gaggaacagt acaactccac ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat       660
tggctgaacg gcaaggagta caagtgcaag gtgtccaaca aggctctgcc tgctcctatc       720
gagaagacca tcagcaaggc caagggccag cctcgggagc ctcaagtgta caccctgcct       780
ccttctcggg acgagctgac caagaaccag gtgtctctta catgcctggt gaaaggcttc       840
tacccttccg acatcgccgt ggaatgggag tccaatggcc agcccgagaa caactacaag       900
accacacctc ctgtgctgga ctctgacggc tccttcttcc tgtactccaa gctgacagtg       960
gataagtcca gatggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg      1020
cacaaccact acacccagaa gtctctgagc ctgtcccctg gaaaa                      1065

<210>  31
<211>  358
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-Fc的全长氨基酸序列


<400>  31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            260                 265                 270         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         
Ser Leu Ser Pro Gly Lys 
        355             

<210>  32
<211>  1074
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-Fc的全长核苷酸序列


<400>  32
caggtgcagt tggttgaatc tggcggcgga tctgtgcagg ctggcggatc tctgagactg        60
tcctgtgccg cttccggcgt caccttcaac tccgcttgca tgggatggtt cagacaggcc       120
cctggcaaag agagagaggg cgtcgctagg atcgagaccg gctatggcgg aaccgtctac       180
gccgactccg tcaagggcag gttcaccatc agcagagaca acgccaagaa caccgtgtac       240
ctgcagatga actccctgaa gcccgaggac accgccatgt actactgtgc tgccaagaga       300
agctggtgca cccctacctg gtggcacgag ctggactaca actactgggg ccagggcaca       360
caggtcaccg tgtcctctga gcctaagtcc tgcgacaaga cccacacctg tcctccatgt       420
cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggat       480
accctgatga tctctcggac ccctgaagtg acctgcgtgg tggtggatgt gtctcacgag       540
gatcccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa tgctaagacc       600
aagcctagag aggaacagta caactccacc tatagagtgg tgtccgtgct gaccgtgctg       660
caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct       720
gctcctatcg aaaagaccat ctccaaggcc aagggccagc ctagggaacc ccaggtttac       780
accttgcctc catctcggga cgagctgacc aagaaccagg tgtccctgac ctgtctggtc       840
aagggcttct acccctccga tatcgccgtg gaatgggagt ctaatggcca gccagagaac       900
aactacaaga caacccctcc tgtgctggac tccgacggct cattcttcct gtactccaag       960
ctgacagtgg acaagtccag atggcagcag ggcaacgtgt tctcctgctc cgtgatgcac      1020
gaggccctgc acaatcacta cacccagaag tccctgtctc tgagccccgg caaa            1074

<210>  33
<211>  350
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B10-Fc的全长氨基酸序列


<400>  33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Glu Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 

<210>  34
<211>  1050
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B10-Fc的全长核苷酸序列


<400>  34
gaggtgcaac tggtggagtc tggaggcggt tccgtgcagg ccggcggctc cctgagactg        60
tcctgcaccg cttccggcta caccttcaga ggctggaaca agcactggta tcggcaggct       120
cctggcaaag aaagagagct ggtgtcctcc atcttccggg acggcaagac cgcctacacc       180
gactccgtga agggcagatt caccatctct caggactctg ccgacgccac agtgtacctg       240
cagatgaact ctctgaagcc cgaggacacc gccatgtact actgcaagta cgacctgcct       300
ggatctggcc tgcccgagtt ctggggccaa ggcaccctgg taaccgtgtc gtccgagccc       360
aagtcttgcg acaagaccca cacctgtcct ccttgtcctg ctccggaact gctgggcggc       420
ccttccgtgt ttctgtttcc tccaaagcct aaggacacac tgatgatcag ccggacccct       480
gaggtgacct gcgtggtcgt ggatgtctct cacgaggatc ctgaggtgaa gttcaactgg       540
tacgtggatg gagtggaagt gcataacgct aaaaccaagc ctagagaaga gcagtacaac       600
tccacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa       660
gagtacaagt gcaaggtgtc caacaaggct ctgcctgccc ctatcgagaa gaccatctcc       720
aaggccaagg gccagcctcg ggagcctcaa gtgtacaccc tgcctccttc tcgcgacgag       780
ctgaccaaga accaggtgtc tctgacctgc ctggtgaaag gcttctaccc ctccgacatc       840
gccgtggaat gggagtccaa tggccagccc gagaacaact acaagaccac cccacctgtg       900
ctggactctg atggctcctt cttcctgtac tccaagctga ccgtggacaa gtccagatgg       960
cagcagggca acgtgttctc ctgttctgtg atgcacgagg ccctgcacaa ccactacaca      1020
cagaagtccc tgagcctgtc tcctggcaag                                       1050

<210>  35
<211>  54
<212>  PRT
<213>  智人(Homo sapiens)

<400>  35
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          
Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              
Val Lys Gly Thr Asn Ala 
    50                  

<210>  36
<211>  53
<212>  PRT
<213>  食蟹猕猴(Macaca fascicularis)

<400>  36
Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
            20                  25                  30          
Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
        35                  40                  45              
Lys Gly Met Asn Ala 
    50              

