
                                SEQUENCE LISTING

<110> PEKING UNIVERSITY

<120> CIRCULAR RNA VACCINES AND METHODS OF USE THEREOF

<130> FE00435PCT

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> PCT/CN2021/074998 
<151> 2021-02-03

<150> PCT/CN2020/110486
<151> 2020-08-21

<160> 95

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1273
<212> PRT
<213> SARS-CoV-2

<400> 1
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val
 1               5                  10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys
    290                 295                 300                 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val
305                 310                 315                 320 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys
                325                 330                 335     
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala
            340                 345                 350         
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu
        355                 360                 365             
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro
    370                 375                 380                 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe
385                 390                 395                 400 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly
                405                 410                 415     
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys
            420                 425                 430         
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn
        435                 440                 445             
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe
    450                 455                 460                 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys
465                 470                 475                 480 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly
                485                 490                 495     
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val
            500                 505                 510         
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys
        515                 520                 525             
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn
    530                 535                 540                 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu
545                 550                 555                 560 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val
                565                 570                 575     
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe
            580                 585                 590         
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val
        595                 600                 605             
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile
    610                 615                 620                 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser
625                 630                 635                 640 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val
                645                 650                 655     
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala
            660                 665                 670         
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala
        675                 680                 685             
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser
    690                 695                 700                 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile
705                 710                 715                 720 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val
                725                 730                 735     
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu
            740                 745                 750         
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr
        755                 760                 765             
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln
    770                 775                 780                 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe
785                 790                 795                 800 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser
                805                 810                 815     
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly
            820                 825                 830         
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp
        835                 840                 845             
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu
    850                 855                 860                 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly
865                 870                 875                 880 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile
                885                 890                 895     
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr
            900                 905                 910         
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn
        915                 920                 925             
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala
    930                 935                 940                 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn
945                 950                 955                 960 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val
                965                 970                 975     
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln
            980                 985                 990         
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val
        995                 1000                1005            
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu
    1010                1015                1020                
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val
1025                1030                1035               1040 
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala
                1045                1050                1055    
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu
            1060                1065                1070        
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His
        1075                1080                1085            
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val
    1090                1095                1100                
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr
1105                1110                1115               1120 
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr
                1125                1130                1135    
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu
            1140                1145                1150        
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp
        1155                1160                1165            
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp
    1170                1175                1180                
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu
1185                1190                1195               1200 
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile
                1205                1210                1215    
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile
            1220                1225                1230        
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys
        1235                1240                1245            
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val
    1250                1255                1260                
Leu Lys Gly Val Lys Leu His Tyr Thr
1265                1270            


<210> 2
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn
 1               5                  10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val
            20                  25                  30          
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser
        35                  40                  45              
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val
    50                  55                  60                  
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp
65                  70                  75                  80  
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln
                85                  90                  95      
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr
            100                 105                 110         
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly
        115                 120                 125             
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr
145                 150                 155                 160 
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser
                165                 170                 175     
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val
            180                 185                 190         
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly
        195                 200                 205             
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe
    210                 215                 220             


<210> 3
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val
 1               5                  10                  15      
Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Arg Ser
            20                  25                  30          


<210> 4
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile
 1               5                  10                  15      
Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu
            20                  25                  30          
Arg
    


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10  


<210> 6
<211> 588
<212> PRT
<213> SARS-CoV-2

<400> 6
Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala
 1               5                  10                  15      
Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn
            20                  25                  30          
Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys
        35                  40                  45              
Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys
    50                  55                  60                  
Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg
65                  70                  75                  80  
Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val
                85                  90                  95      
Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe
            100                 105                 110         
Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser
        115                 120                 125             
Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala
    130                 135                 140                 
Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala
145                 150                 155                 160 
Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu
                165                 170                 175     
Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu
            180                 185                 190         
Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala
        195                 200                 205             
Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile
    210                 215                 220                 
Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn
225                 230                 235                 240 
Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr
                245                 250                 255     
Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln
            260                 265                 270         
Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile
        275                 280                 285             
Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala
    290                 295                 300                 
Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln
305                 310                 315                 320 
Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser
                325                 330                 335     
Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser
            340                 345                 350         
Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro
        355                 360                 365             
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro
    370                 375                 380                 
Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly
385                 390                 395                 400 
Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His
                405                 410                 415     
Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr
            420                 425                 430         
Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val
        435                 440                 445             
Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys
    450                 455                 460                 
Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp
465                 470                 475                 480 
Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys
                485                 490                 495     
Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu
            500                 505                 510         
Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro
        515                 520                 525             
Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met
    530                 535                 540                 
Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys
545                 550                 555                 560 
Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser
                565                 570                 575     
Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr
            580                 585             


<210> 7
<211> 588
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala
 1               5                  10                  15      
Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn
            20                  25                  30          
Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys
        35                  40                  45              
Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys
    50                  55                  60                  
Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg
65                  70                  75                  80  
Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val
                85                  90                  95      
Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe
            100                 105                 110         
Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser
        115                 120                 125             
Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala
    130                 135                 140                 
Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala
145                 150                 155                 160 
Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu
                165                 170                 175     
Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu
            180                 185                 190         
Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala
        195                 200                 205             
Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile
    210                 215                 220                 
Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn
225                 230                 235                 240 
Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr
                245                 250                 255     
Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln
            260                 265                 270         
Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile
        275                 280                 285             
Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala
    290                 295                 300                 
Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln
305                 310                 315                 320 
Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser
                325                 330                 335     
Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser
            340                 345                 350         
Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro
        355                 360                 365             
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro
    370                 375                 380                 
Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly
385                 390                 395                 400 
Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His
                405                 410                 415     
Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr
            420                 425                 430         
Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val
        435                 440                 445             
Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys
    450                 455                 460                 
Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp
465                 470                 475                 480 
Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys
                485                 490                 495     
Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu
            500                 505                 510         
Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro
        515                 520                 525             
Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met
    530                 535                 540                 
Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys
545                 550                 555                 560 
Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser
                565                 570                 575     
Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr
            580                 585             


<210> 8
<211> 1272
<212> PRT
<213> SARS-CoV-2

<400> 8
Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn
 1               5                  10                  15      
Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr
            20                  25                  30          
Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His
        35                  40                  45              
Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe
    50                  55                  60                  
His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn
65                  70                  75                  80  
Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys
                85                  90                  95      
Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys
            100                 105                 110         
Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys
        115                 120                 125             
Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr
    130                 135                 140                 
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser
145                 150                 155                 160 
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met
                165                 170                 175     
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val
            180                 185                 190         
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro
        195                 200                 205             
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro
    210                 215                 220                 
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu
225                 230                 235                 240 
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly
                245                 250                 255     
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg
            260                 265                 270         
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val
        275                 280                 285             
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser
    290                 295                 300                 
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln
305                 310                 315                 320 
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro
                325                 330                 335     
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp
            340                 345                 350         
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr
        355                 360                 365             
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr
    370                 375                 380                 
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
385                 390                 395                 400 
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
                405                 410                 415     
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val
            420                 425                 430         
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr
        435                 440                 445             
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu
    450                 455                 460                 
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
465                 470                 475                 480 
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe
                485                 490                 495     
Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu
            500                 505                 510         
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys
        515                 520                 525             
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly
    530                 535                 540                 
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro
545                 550                 555                 560 
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg
                565                 570                 575     
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly
            580                 585                 590         
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala
        595                 600                 605             
Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His
    610                 615                 620                 
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn
625                 630                 635                 640 
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn
                645                 650                 655     
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser
            660                 665                 670         
Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser
        675                 680                 685             
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val
    690                 695                 700                 
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser
705                 710                 715                 720 
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp
                725                 730                 735     
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu
            740                 745                 750         
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly
        755                 760                 765             
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val
    770                 775                 780                 
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn
785                 790                 795                 800 
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe
                805                 810                 815     
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe
            820                 825                 830         
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu
        835                 840                 845             
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu
    850                 855                 860                 
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr
865                 870                 875                 880 
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro
                885                 890                 895     
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln
            900                 905                 910         
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser
        915                 920                 925             
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu
    930                 935                 940                 
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr
945                 950                 955                 960 
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu
                965                 970                 975     
Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile
            980                 985                 990         
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr
        995                 1000                1005            
Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala
    1010                1015                1020                
Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp
1025                1030                1035               1040 
Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro
                1045                1050                1055    
His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys
            1060                1065                1070        
Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe
        1075                1080                1085            
Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr
    1090                1095                1100                
Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe
1105                1110                1115               1120 
Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val
                1125                1130                1135    
Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp
            1140                1145                1150        
Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile
        1155                1160                1165            
Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg
    1170                1175                1180                
Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln
1185                1190                1195               1200 
Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp
                1205                1210                1215    
Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met
            1220                1225                1230        
Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser
        1235                1240                1245            
Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu
    1250                1255                1260                
Lys Gly Val Lys Leu His Tyr Thr
1265                1270        


<210> 9
<211> 1268
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn
 1               5                  10                  15      
Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr
            20                  25                  30          
Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His
        35                  40                  45              
Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe
    50                  55                  60                  
His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn
65                  70                  75                  80  
Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys
                85                  90                  95      
Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys
            100                 105                 110         
Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys
        115                 120                 125             
Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr
    130                 135                 140                 
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser
145                 150                 155                 160 
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met
                165                 170                 175     
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val
            180                 185                 190         
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro
        195                 200                 205             
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro
    210                 215                 220                 
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu
225                 230                 235                 240 
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly
                245                 250                 255     
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg
            260                 265                 270         
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val
        275                 280                 285             
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser
    290                 295                 300                 
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln
305                 310                 315                 320 
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro
                325                 330                 335     
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp
            340                 345                 350         
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr
        355                 360                 365             
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr
    370                 375                 380                 
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
385                 390                 395                 400 
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
                405                 410                 415     
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val
            420                 425                 430         
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr
        435                 440                 445             
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu
    450                 455                 460                 
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
465                 470                 475                 480 
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe
                485                 490                 495     
Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu
            500                 505                 510         
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys
        515                 520                 525             
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly
    530                 535                 540                 
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro
545                 550                 555                 560 
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg
                565                 570                 575     
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly
            580                 585                 590         
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala
        595                 600                 605             
Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His
    610                 615                 620                 
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn
625                 630                 635                 640 
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn
                645                 650                 655     
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser
            660                 665                 670         
Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile Ile
        675                 680                 685             
Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn
    690                 695                 700                 
Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu
705                 710                 715                 720 
Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr
                725                 730                 735     
Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly
            740                 745                 750         
Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu
        755                 760                 765             
Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr
    770                 775                 780                 
Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile
785                 790                 795                 800 
Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu
                805                 810                 815     
Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr
            820                 825                 830         
Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln
        835                 840                 845             
Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met
    850                 855                 860                 
Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly
865                 870                 875                 880 
Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln
                885                 890                 895     
Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr
            900                 905                 910         
Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys
        915                 920                 925             
Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln
    930                 935                 940                 
Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln
945                 950                 955                 960 
Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu
                965                 970                 975     
Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile
            980                 985                 990         
Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile
        995                 1000                1005            
Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala Thr Lys Met
    1010                1015                1020                
Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe Cys Gly Lys
1025                1030                1035               1040 
Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro His Gly Val Val
                1045                1050                1055    
Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys Asn Phe Thr Thr
            1060                1065                1070        
Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe Pro Arg Glu Gly
        1075                1080                1085            
Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe
    1090                1095                1100                
Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn
1105                1110                1115               1120 
Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu
                1125                1130                1135    
Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys
            1140                1145                1150        
Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn
        1155                1160                1165            
Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val
    1170                1175                1180                
Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys
1185                1190                1195               1200 
Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile
                1205                1210                1215    
Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys Met
            1220                1225                1230        
Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser Cys
        1235                1240                1245            
Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys Gly Val Lys
    1250                1255                1260                
Leu His Tyr Thr
1265            


<210> 10
<211> 1268
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn
 1               5                  10                  15      
Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr
            20                  25                  30          
Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His
        35                  40                  45              
Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe
    50                  55                  60                  
His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn
65                  70                  75                  80  
Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys
                85                  90                  95      
Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys
            100                 105                 110         
Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys
        115                 120                 125             
Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr
    130                 135                 140                 
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser
145                 150                 155                 160 
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met
                165                 170                 175     
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val
            180                 185                 190         
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro
        195                 200                 205             
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro
    210                 215                 220                 
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu
225                 230                 235                 240 
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly
                245                 250                 255     
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg
            260                 265                 270         
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val
        275                 280                 285             
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser
    290                 295                 300                 
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln
305                 310                 315                 320 
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro
                325                 330                 335     
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp
            340                 345                 350         
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr
        355                 360                 365             
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr
    370                 375                 380                 
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
385                 390                 395                 400 
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
                405                 410                 415     
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val
            420                 425                 430         
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr
        435                 440                 445             
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu
    450                 455                 460                 
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
465                 470                 475                 480 
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe
                485                 490                 495     
Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu
            500                 505                 510         
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys
        515                 520                 525             
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly
    530                 535                 540                 
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro
545                 550                 555                 560 
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg
                565                 570                 575     
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly
            580                 585                 590         
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala
        595                 600                 605             
Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His
    610                 615                 620                 
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn
625                 630                 635                 640 
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn
                645                 650                 655     
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser
            660                 665                 670         
Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile Ile
        675                 680                 685             
Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn
    690                 695                 700                 
Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu
705                 710                 715                 720 
Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr
                725                 730                 735     
Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly
            740                 745                 750         
Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu
        755                 760                 765             
Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr
    770                 775                 780                 
Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile
785                 790                 795                 800 
Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu
                805                 810                 815     
Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr
            820                 825                 830         
Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln
        835                 840                 845             
Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met
    850                 855                 860                 
Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly
865                 870                 875                 880 
Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln
                885                 890                 895     
Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr
            900                 905                 910         
Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys
        915                 920                 925             
Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln
    930                 935                 940                 
Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln
945                 950                 955                 960 
Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu
                965                 970                 975     
Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile
            980                 985                 990         
Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile
        995                 1000                1005            
Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala Thr Lys Met
    1010                1015                1020                
Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe Cys Gly Lys
1025                1030                1035               1040 
Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro His Gly Val Val
                1045                1050                1055    
Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys Asn Phe Thr Thr
            1060                1065                1070        
Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe Pro Arg Glu Gly
        1075                1080                1085            
Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe
    1090                1095                1100                
Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn
1105                1110                1115               1120 
Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu
                1125                1130                1135    
Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys
            1140                1145                1150        
Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn
        1155                1160                1165            
Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val
    1170                1175                1180                
Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys
1185                1190                1195               1200 
Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile
                1205                1210                1215    
Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys Met
            1220                1225                1230        
Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser Cys
        1235                1240                1245            
Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys Gly Val Lys
    1250                1255                1260                
Leu His Tyr Thr
1265            


<210> 11
<211> 1764
<212> RNA
<213> SARS-CoV-2

<400> 11
aguguggcuu cucaaagcau uauagcauac acuaugucuc uuggugccga aaauuccgug 60
gccuauucua acaauucaau cgccauccca accaacuuca caauuagcgu gacuaccgaa 120
auacugccug ugagcaugac gaaaaccagc guagacugca cuauguauau cuguggagac 180
uccacugagu gcuccaaccu ucuccugcag uacgguagcu ucuguaccca auugaaccgc 240
gcccuuacag gcaucgcugu ugagcaagau aagaauaccc aggaaguuuu ugcccagguu 300
aagcagauau acaaaacacc gcccauuaag gacuucggag gcuucaacuu cucucagaua 360
cugccugacc ccuccaagcc aucaaaacgc agcuucauug aggaccucuu guucaacaaa 420
gugacucugg cugaugcugg cuucauuaag caguacggag auugccuggg agauauugcu 480
gccagggacc ucaucugcgc ccagaaguuu aauggccuga cagucuugcc cccacuucug 540
acagacgaga ugauugcuca guacacaucu gcccuccucg cuggcaccau aacauccgga 600
uggacauuug gugcuggugc ugcccuccag auucccuucg caaugcagau ggcguaucgc 660
uuuaacggca ucggugucac acaaaacgug uuguaugaga accaaaagcu caucgcuaac 720
caguuuaauu cugcuauugg uaagauucag gacagccugu caucaaccgc gucugcccuu 780
gguaaguugc aggacguggu gaaccagaau gcucaggcuu ugaauacucu ggugaagcaa 840
cucucuucaa auuucggcgc uaucucuucu guguugaacg acauccugag ucgccuugau 900
aagguggaag cugaaguuca aauugauaga uugauuacug gcaggcucca gucuuugcag 960
accuacguua cacagcagcu gauuagggcg gcugaaauua gagcuuccgc caaucuggcu 1020
gcaaccaaga uguccgaaug cguccugggu cagucaaagc gcguugacuu uugugguaaa 1080
ggcuaccacc ucaugucauu uccccaguca gcaccucacg gaguaguguu ccuccacguc 1140
accuacguuc cagcacagga aaagaauuuu accacugcgc cggcaaucug ucacgacggu 1200
aaggcacacu ucccccgcga gggcguauuc gugucuaacg gaacucauug guucgucaca 1260
cagagaaacu ucuaugagcc ucagaucauu accaccgaca auacauuugu guccgguaac 1320
ugcgacguug ugauuggaau cgucaacaac acuguguacg auccacuuca gccagaacug 1380
gauagcuuca aggaagaauu ggacaaauau uucaaaaauc acacuucacc cgauguggac 1440
cugggugaca uuagugguau caaugcgucc guggucaaua uucaaaaaga gauugacagg 1500
cucaacgaag uggccaagaa ccugaacgaa agucuuaucg aucugcaaga auugggaaag 1560
uaugagcagu acaucaagug gccgugguac auuugguugg guuuuaucgc cggucugauc 1620
gccaucguua ugguuaccau uaugcuuugc ugcaugacga gcuguugcuc cugucugaag 1680
ggaugcugcu cuugcggauc auguugcaag uucgaugaag acgauagcga accaguucug 1740
aagggcguca agcugcauua caca                                        1764

<210> 12
<211> 1764
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
agtgtggctt ctcaaagcat tatagcatac actatgtctc ttggtgccga aaattccgtg 60
gcctattcta acaattcaat cgccatccca accaacttca caattagcgt gactaccgaa 120
atactgcctg tgagcatgac gaaaaccagc gtagactgca ctatgtatat ctgtggagac 180
tccactgagt gctccaacct tctcctgcag tacggtagct tctgtaccca attgaaccgc 240
gcccttacag gcatcgctgt tgagcaagat aagaataccc aggaagtttt tgcccaggtt 300
aagcagatat acaaaacacc gcccattaag gacttcggag gcttcaactt ctctcagata 360
ctgcctgacc cctccaagcc atcaaaacgc agcttcattg aggacctctt gttcaacaaa 420
gtgactctgg ctgatgctgg cttcattaag cagtacggag attgcctggg agatattgct 480
gccagggacc tcatctgcgc ccagaagttt aatggcctga cagtcttgcc cccacttctg 540
acagacgaga tgattgctca gtacacatct gccctcctcg ctggcaccat aacatccgga 600
tggacatttg gtgctggtgc tgccctccag attcccttcg caatgcagat ggcgtatcgc 660
tttaacggca tcggtgtcac acaaaacgtg ttgtatgaga accaaaagct catcgctaac 720
cagtttaatt ctgctattgg taagattcag gacagcctgt catcaaccgc gtctgccctt 780
ggtaagttgc aggacgtggt gaaccagaat gctcaggctt tgaatactct ggtgaagcaa 840
ctctcttcaa atttcggcgc tatctcttct gtgttgaacg acatcctgag tcgccttgat 900
cctccagaag ctgaagttca aattgataga ttgattactg gcaggctcca gtctttgcag 960
acctacgtta cacagcagct gattagggcg gctgaaatta gagcttccgc caatctggct 1020
gcaaccaaga tgtccgaatg cgtcctgggt cagtcaaagc gcgttgactt ttgtggtaaa 1080
ggctaccacc tcatgtcatt tccccagtca gcacctcacg gagtagtgtt cctccacgtc 1140
acctacgttc cagcacagga aaagaatttt accactgcgc cggcaatctg tcacgacggt 1200
aaggcacact tcccccgcga gggcgtattc gtgtctaacg gaactcattg gttcgtcaca 1260
cagagaaact tctatgagcc tcagatcatt accaccgaca atacatttgt gtccggtaac 1320
tgcgacgttg tgattggaat cgtcaacaac actgtgtacg atccacttca gccagaactg 1380
gatagcttca aggaagaatt ggacaaatat ttcaaaaatc acacttcacc cgatgtggac 1440
ctgggtgaca ttagtggtat caatgcgtcc gtggtcaata ttcaaaaaga gattgacagg 1500
ctcaacgaag tggccaagaa cctgaacgaa agtcttatcg atctgcaaga attgggaaag 1560
tatgagcagt acatcaagtg gccgtggtac atttggttgg gttttatcgc cggtctgatc 1620
gccatcgtta tggttaccat tatgctttgc tgcatgacga gctgttgctc ctgtctgaag 1680
ggatgctgct cttgcggatc atgttgcaag ttcgatgaag acgatagcga accagttctg 1740
aagggcgtca agctgcatta caca                                        1764

<210> 13
<211> 1764
<212> RNA
<213> SARS-CoV-2

<400> 13
aguguggcuu cucaaagcau uauagcauac acuaugucuc uuggugccga aaauuccgug 60
gccuauucua acaauucaau cgccauccca accaacuuca caauuagcgu gacuaccgaa 120
auacugccug ugagcaugac gaaaaccagc guagacugca cuauguauau cuguggagac 180
uccacugagu gcuccaaccu ucuccugcag uacgguagcu ucuguaccca auugaaccgc 240
gcccuuacag gcaucgcugu ugagcaagau aagaauaccc aggaaguuuu ugcccagguu 300
aagcagauau acaaaacacc gcccauuaag gacuucggag gcuucaacuu cucucagaua 360
cugccugacc ccuccaagcc aucaaaacgc agcuucauug aggaccucuu guucaacaaa 420
gugacucugg cugaugcugg cuucauuaag caguacggag auugccuggg agauauugcu 480
gccagggacc ucaucugcgc ccagaaguuu aauggccuga cagucuugcc cccacuucug 540
acagacgaga ugauugcuca guacacaucu gcccuccucg cuggcaccau aacauccgga 600
uggacauuug gugcuggugc ugcccuccag auucccuucg caaugcagau ggcguaucgc 660
uuuaacggca ucggugucac acaaaacgug uuguaugaga accaaaagcu caucgcuaac 720
caguuuaauu cugcuauugg uaagauucag gacagccugu caucaaccgc gucugcccuu 780
gguaaguugc aggacguggu gaaccagaau gcucaggcuu ugaauacucu ggugaagcaa 840
cucucuucaa auuucggcgc uaucucuucu guguugaacg acauccugag ucgccuugau 900
ccuccagaag cugaaguuca aauugauaga uugauuacug gcaggcucca gucuuugcag 960
accuacguua cacagcagcu gauuagggcg gcugaaauua gagcuuccgc caaucuggcu 1020
gcaaccaaga uguccgaaug cguccugggu cagucaaagc gcguugacuu uugugguaaa 1080
ggcuaccacc ucaugucauu uccccaguca gcaccucacg gaguaguguu ccuccacguc 1140
accuacguuc cagcacagga aaagaauuuu accacugcgc cggcaaucug ucacgacggu 1200
aaggcacacu ucccccgcga gggcguauuc gugucuaacg gaacucauug guucgucaca 1260
cagagaaacu ucuaugagcc ucagaucauu accaccgaca auacauuugu guccgguaac 1320
ugcgacguug ugauuggaau cgucaacaac acuguguacg auccacuuca gccagaacug 1380
gauagcuuca aggaagaauu ggacaaauau uucaaaaauc acacuucacc cgauguggac 1440
cugggugaca uuagugguau caaugcgucc guggucaaua uucaaaaaga gauugacagg 1500
cucaacgaag uggccaagaa ccugaacgaa agucuuaucg aucugcaaga auugggaaag 1560
uaugagcagu acaucaagug gccgugguac auuugguugg guuuuaucgc cggucugauc 1620
gccaucguua ugguuaccau uaugcuuugc ugcaugacga gcuguugcuc cugucugaag 1680
ggaugcugcu cuugcggauc auguugcaag uucgaugaag acgauagcga accaguucug 1740
aagggcguca agcugcauua caca                                        1764

<210> 14
<211> 3804
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
uucguuuucc uuguucuguu gccucucguu aguagccaau gcgucaaccu uacuacuaga 60
acccagcucc cuccagcaua uaccaacucu uucaccaggg gcguauauua cccggacaaa 120
guguuccgcu caagugugcu gcauucuacg caggaccuuu ucuugcccuu uuucaguaau 180
guuacuuggu uucaugcuau ccaugugucu ggaacuaacg gaaccaagcg cuuugacaac 240
cccguccucc cuuucaacga uggcguguac uucgcuucca cggaaaaguc aaacauaauu 300
cgcggcugga ucuuugguac aacacucgac ucaaagacgc agagccugcu gaucguuaau 360
aacgcuacaa auguugugau aaaggugugu gaauuucagu ucugcaauga ucccuuccug 420
gguguguacu accauaagaa uaacaagagc uggauggaau ccgaauuuag gguuuacagu 480
uccgcuaaca acugcacauu cgaauacgua agccagccau uucuuaugga ucuugagggc 540
aagcaaggaa acuucaagaa cuugagggag uucguguuca aaaauaucga cggcuauuuu 600
aagauauaua gcaagcacac uccaauaaac uuggugcgcg accugcccca gggauucucu 660
gcucuggagc cccuggugga ucugcccauu ggaauaaaca uaacucgcuu ucaaacacug 720
cucgcccugc aucgcaguua ccucaccccu ggugauagua guucaggaug gacagcagga 780
gccgccgcau acuacgucgg cuaccugcag ccuaggaccu ucuugcugaa guacaacgag 840
aacgguacaa uaacugacgc uguggacugc gcucuggacc cucuguccga gacgaagugc 900
acccugaaga gcuuuacugu ugaaaaaggc auuuaccaaa ccagcaacuu ccgcguccag 960
ccaaccgaga gcaucgucag auuucccaac auuacaaauc ugugucccuu cggcgaggug 1020
uucaacgcca cacgcuucgc uucaguguac gcauggaacc gcaagcgcau aucuaacugc 1080
gucgcggauu auucuguccu cuacaacucc gccucuuucu ccaccuucaa gugcuacgga 1140
gugucaccga cuaagcugaa cgaucucugc uuuaccaacg ucuacgcgga cuccuucgug 1200
auaagaggug augaagugag acaaauagcc ccaggucaga cugguaagau cgcagauuac 1260
aacuacaaau ugccugauga uuucacuggu ugcguuaucg cguggaacuc uaauaaccuc 1320
gauucuaagg ucggugguaa cuacaauuac cuguaccgcu uguuuaggaa gucaaaccug 1380
aagccuuucg agagggauau uucaaccgaa aucuaucaag cggguucaac accguguaac 1440
gguguggaag gauuuaacug cuacuucccc cugcagucuu acggauucca gccaaccaau 1500
ggcguggguu accaaccuua ucgcguggug guucugaguu ucgaacuguu gcacgcuccc 1560
gccacgguau gcggucccaa gaagagcacu aacuugguga agaauaagug cgugaauuuc 1620
aauuucaaug gccucacugg aacuggagug cugaccgaau ccaauaagaa guucuugccc 1680
uuccagcagu ucggaagaga cauugcugac acaaccgacg cggugcgcga uccucagacu 1740
cuggagauau uggacauuac accauguucu uucggcggug ugucugucau uacuccgggc 1800
acgaauacua gcaaccaggu agccgugcug uaccaagacg ugaauugcac agagguuccc 1860
gucgcaauuc acgcugacca gcugaccccc acguggaggg uuuacagcac ugguaguaac 1920
gucuuccaga cgagagccgg uugcuugauc ggagcggaac augugaauaa cuccuacgag 1980
ugcgacaucc ccaucggagc cgguauaugc gccucuuauc agacacaaac uaacucacgc 2040
aguguggcuu cucaaagcau uauagcauac acuaugucuc uuggugccga aaauuccgug 2100
gccuauucua acaauucaau cgccauccca accaacuuca caauuagcgu gacuaccgaa 2160
auacugccug ugagcaugac gaaaaccagc guagacugca cuauguauau cuguggagac 2220
uccacugagu gcuccaaccu ucuccugcag uacgguagcu ucuguaccca auugaaccgc 2280
gcccuuacag gcaucgcugu ugagcaagau aagaauaccc aggaaguuuu ugcccagguu 2340
aagcagauau acaaaacacc gcccauuaag gacuucggag gcuucaacuu cucucagaua 2400
cugccugacc ccuccaagcc aucaaaacgc agcuucauug aggaccucuu guucaacaaa 2460
gugacucugg cugaugcugg cuucauuaag caguacggag auugccuggg agauauugcu 2520
gccagggacc ucaucugcgc ccagaaguuu aauggccuga cagucuugcc cccacuucug 2580
acagacgaga ugauugcuca guacacaucu gcccuccucg cuggcaccau aacauccgga 2640
uggacauuug gugcuggugc ugcccuccag auucccuucg caaugcagau ggcguaucgc 2700
uuuaacggca ucggugucac acaaaacgug uuguaugaga accaaaagcu caucgcuaac 2760
caguuuaauu cugcuauugg uaagauucag gacagccugu caucaaccgc gucugcccuu 2820
gguaaguugc aggacguggu gaaccagaau gcucaggcuu ugaauacucu ggugaagcaa 2880
cucucuucaa auuucggcgc uaucucuucu guguugaacg acauccugag ucgccuugau 2940
aagguggaag cugaaguuca aauugauaga uugauuacug gcaggcucca gucuuugcag 3000
accuacguua cacagcagcu gauuagggcg gcugaaauua gagcuuccgc caaucuggcu 3060
gcaaccaaga uguccgaaug cguccugggu cagucaaagc gcguugacuu uugugguaaa 3120
ggcuaccacc ucaugucauu uccccaguca gcaccucacg gaguaguguu ccuccacguc 3180
accuacguuc cagcacagga aaagaauuuu accacugcgc cggcaaucug ucacgacggu 3240
aaggcacacu ucccccgcga gggcguauuc gugucuaacg gaacucauug guucgucaca 3300
cagagaaacu ucuaugagcc ucagaucauu accaccgaca auacauuugu guccgguaac 3360
ugcgacguug ugauuggaau cgucaacaac acuguguacg auccacuuca gccagaacug 3420
gauagcuuca aggaagaauu ggacaaauau uucaaaaauc acacuucacc cgauguggac 3480
cugggugaca uuagugguau caaugcgucc guggucaaua uucaaaaaga gauugacagg 3540
cucaacgaag uggccaagaa ccugaacgaa agucuuaucg aucugcaaga auugggaaag 3600
uaugagcagu acaucaagug gccgugguac auuugguugg guuuuaucgc cggucugauc 3660
gccaucguua ugguuaccau uaugcuuugc ugcaugacga gcuguugcuc cugucugaag 3720
ggaugcugcu cuugcggauc auguugcaag uucgaugaag acgauagcga accaguucug 3780
aagggcguca agcugcauua caca                                        3804

<210> 15
<211> 3804
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
uucguuuucc uuguucuguu gccucucguu aguagccaau gcgucaaccu uacuacuaga 60
acccagcucc cuccagcaua uaccaacucu uucaccaggg gcguauauua cccggacaaa 120
guguuccgcu caagugugcu gcauucuacg caggaccuuu ucuugcccuu uuucaguaau 180
guuacuuggu uucaugcuau ccaugugucu ggaacuaacg gaaccaagcg cuuugacaac 240
cccguccucc cuuucaacga uggcguguac uucgcuucca cggaaaaguc aaacauaauu 300
cgcggcugga ucuuugguac aacacucgac ucaaagacgc agagccugcu gaucguuaau 360
aacgcuacaa auguugugau aaaggugugu gaauuucagu ucugcaauga ucccuuccug 420
gguguguacu accauaagaa uaacaagagc uggauggaau ccgaauuuag gguuuacagu 480
uccgcuaaca acugcacauu cgaauacgua agccagccau uucuuaugga ucuugagggc 540
aagcaaggaa acuucaagaa cuugagggag uucguguuca aaaauaucga cggcuauuuu 600
aagauauaua gcaagcacac uccaauaaac uuggugcgcg accugcccca gggauucucu 660
gcucuggagc cccuggugga ucugcccauu ggaauaaaca uaacucgcuu ucaaacacug 720
cucgcccugc aucgcaguua ccucaccccu ggugauagua guucaggaug gacagcagga 780
gccgccgcau acuacgucgg cuaccugcag ccuaggaccu ucuugcugaa guacaacgag 840
aacgguacaa uaacugacgc uguggacugc gcucuggacc cucuguccga gacgaagugc 900
acccugaaga gcuuuacugu ugaaaaaggc auuuaccaaa ccagcaacuu ccgcguccag 960
ccaaccgaga gcaucgucag auuucccaac auuacaaauc ugugucccuu cggcgaggug 1020
uucaacgcca cacgcuucgc uucaguguac gcauggaacc gcaagcgcau aucuaacugc 1080
gucgcggauu auucuguccu cuacaacucc gccucuuucu ccaccuucaa gugcuacgga 1140
gugucaccga cuaagcugaa cgaucucugc uuuaccaacg ucuacgcgga cuccuucgug 1200
auaagaggug augaagugag acaaauagcc ccaggucaga cugguaagau cgcagauuac 1260
aacuacaaau ugccugauga uuucacuggu ugcguuaucg cguggaacuc uaauaaccuc 1320
gauucuaagg ucggugguaa cuacaauuac cuguaccgcu uguuuaggaa gucaaaccug 1380
aagccuuucg agagggauau uucaaccgaa aucuaucaag cggguucaac accguguaac 1440
gguguggaag gauuuaacug cuacuucccc cugcagucuu acggauucca gccaaccaau 1500
ggcguggguu accaaccuua ucgcguggug guucugaguu ucgaacuguu gcacgcuccc 1560
gccacgguau gcggucccaa gaagagcacu aacuugguga agaauaagug cgugaauuuc 1620
aauuucaaug gccucacugg aacuggagug cugaccgaau ccaauaagaa guucuugccc 1680
uuccagcagu ucggaagaga cauugcugac acaaccgacg cggugcgcga uccucagacu 1740
cuggagauau uggacauuac accauguucu uucggcggug ugucugucau uacuccgggc 1800
acgaauacua gcaaccaggu agccgugcug uaccaagacg ugaauugcac agagguuccc 1860
gucgcaauuc acgcugacca gcugaccccc acguggaggg uuuacagcac ugguaguaac 1920
gucuuccaga cgagagccgg uugcuugauc ggagcggaac augugaauaa cuccuacgag 1980
ugcgacaucc ccaucggagc cgguauaugc gccucuuauc agacacaaac uaacucacgc 2040
aguguggcuu cucaaagcau uauagcauac acuaugucuc uuggugccga aaauuccgug 2100
gccuauucua acaauucaau cgccauccca accaacuuca caauuagcgu gacuaccgaa 2160
auacugccug ugagcaugac gaaaaccagc guagacugca cuauguauau cuguggagac 2220
uccacugagu gcuccaaccu ucuccugcag uacgguagcu ucuguaccca auugaaccgc 2280
gcccuuacag gcaucgcugu ugagcaagau aagaauaccc aggaaguuuu ugcccagguu 2340
aagcagauau acaaaacacc gcccauuaag gacuucggag gcuucaacuu cucucagaua 2400
cugccugacc ccuccaagcc aucaaaacgc agcuucauug aggaccucuu guucaacaaa 2460
gugacucugg cugaugcugg cuucauuaag caguacggag auugccuggg agauauugcu 2520
gccagggacc ucaucugcgc ccagaaguuu aauggccuga cagucuugcc cccacuucug 2580
acagacgaga ugauugcuca guacacaucu gcccuccucg cuggcaccau aacauccgga 2640
uggacauuug gugcuggugc ugcccuccag auucccuucg caaugcagau ggcguaucgc 2700
uuuaacggca ucggugucac acaaaacgug uuguaugaga accaaaagcu caucgcuaac 2760
caguuuaauu cugcuauugg uaagauucag gacagccugu caucaaccgc gucugcccuu 2820
gguaaguugc aggacguggu gaaccagaau gcucaggcuu ugaauacucu ggugaagcaa 2880
cucucuucaa auuucggcgc uaucucuucu guguugaacg acauccugag ucgccuugau 2940
ccuccagaag cugaaguuca aauugauaga uugauuacug gcaggcucca gucuuugcag 3000
accuacguua cacagcagcu gauuagggcg gcugaaauua gagcuuccgc caaucuggcu 3060
gcaaccaaga uguccgaaug cguccugggu cagucaaagc gcguugacuu uugugguaaa 3120
ggcuaccacc ucaugucauu uccccaguca gcaccucacg gaguaguguu ccuccacguc 3180
accuacguuc cagcacagga aaagaauuuu accacugcgc cggcaaucug ucacgacggu 3240
aaggcacacu ucccccgcga gggcguauuc gugucuaacg gaacucauug guucgucaca 3300
cagagaaacu ucuaugagcc ucagaucauu accaccgaca auacauuugu guccgguaac 3360
ugcgacguug ugauuggaau cgucaacaac acuguguacg auccacuuca gccagaacug 3420
gauagcuuca aggaagaauu ggacaaauau uucaaaaauc acacuucacc cgauguggac 3480
cugggugaca uuagugguau caaugcgucc guggucaaua uucaaaaaga gauugacagg 3540
cucaacgaag uggccaagaa ccugaacgaa agucuuaucg aucugcaaga auugggaaag 3600
uaugagcagu acaucaagug gccgugguac auuugguugg guuuuaucgc cggucugauc 3660
gccaucguua ugguuaccau uaugcuuugc ugcaugacga gcuguugcuc cugucugaag 3720
ggaugcugcu cuugcggauc auguugcaag uucgaugaag acgauagcga accaguucug 3780
aagggcguca agcugcauua caca                                        3804

<210> 16
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly Ala
 1               5                  10                  15      
Val Phe Val Ser Pro Ser Gln Glu Ile His Ala Arg Phe Arg Arg
            20                  25                  30      


<210> 17
<211> 17
<212> PRT
<213> Homo sapiens

<400> 17
Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His
 1               5                  10                  15      
Ser
    


<210> 18
<211> 634
<212> PRT
<213> Mus musculus

<400> 18
Met Leu Thr Phe Phe Ala Ala Phe Leu Ala Ala Pro Leu Ala Leu Ala
 1               5                  10                  15      
Glu Ser Pro Tyr Leu Val Arg Val Asp Ala Ala Arg Pro Leu Arg Pro
            20                  25                  30          
Leu Leu Pro Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His
        35                  40                  45              
Asp Gln Ala Asp Gln Tyr Asp Leu Ser Trp Asp Gln Gln Leu Asn Leu
    50                  55                  60                  
Ala Tyr Ile Gly Ala Val Pro His Ser Gly Ile Glu Gln Val Arg Ile
65                  70                  75                  80  
His Trp Leu Leu Asp Leu Ile Thr Ala Arg Lys Ser Pro Gly Gln Gly
                85                  90                  95      
Leu Met Tyr Asn Phe Thr His Leu Asp Ala Phe Leu Asp Leu Leu Met
            100                 105                 110         
Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Pro Ser Gly
        115                 120                 125             
Tyr Phe Thr Asp Phe Asp Asp Lys Gln Gln Val Phe Glu Trp Lys Asp
    130                 135                 140                 
Leu Val Ser Leu Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Thr
145                 150                 155                 160 
His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His
                165                 170                 175     
Asp Phe Asp Asn Val Ser Met Thr Thr Gln Gly Phe Leu Asn Tyr Tyr
            180                 185                 190         
Asp Ala Cys Ser Glu Gly Leu Arg Ile Ala Ser Pro Thr Leu Lys Leu
        195                 200                 205             
Gly Gly Pro Gly Asp Ser Phe His Pro Leu Pro Arg Ser Pro Met Cys
    210                 215                 220                 
Trp Ser Leu Leu Gly His Cys Ala Asn Gly Thr Asn Phe Phe Thr Gly
225                 230                 235                 240 
Glu Val Gly Val Arg Leu Asp Tyr Ile Ser Leu His Lys Lys Gly Ala
                245                 250                 255     
Gly Ser Ser Ile Ala Ile Leu Glu Gln Glu Met Ala Val Val Glu Gln
            260                 265                 270         
Val Gln Gln Leu Phe Pro Glu Phe Lys Asp Thr Pro Ile Tyr Asn Asp
        275                 280                 285             
Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala
    290                 295                 300                 
Asp Val Thr Tyr Ala Ala Leu Val Val Lys Val Ile Ala Gln His Gln
305                 310                 315                 320 
Asn Leu Leu Phe Ala Asn Ser Ser Ser Ser Met Arg Tyr Val Leu Leu
                325                 330                 335     
Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro Tyr Pro Phe Ser Gln
            340                 345                 350         
Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr His Pro Pro His
        355                 360                 365             
Val Gln Leu Leu Arg Lys Pro Val Leu Thr Val Met Gly Leu Met Ala
    370                 375                 380                 
Leu Leu Asp Gly Glu Gln Leu Trp Ala Glu Val Ser Lys Ala Gly Ala
385                 390                 395                 400 
Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Thr His His
                405                 410                 415     
Pro Glu Gly Ser Ala Ala Ala Trp Ser Thr Thr Val Leu Ile Tyr Thr
            420                 425                 430         
Ser Asp Asp Thr His Ala His Pro Asn His Ser Ile Pro Val Thr Leu
        435                 440                 445             
Arg Leu Arg Gly Val Pro Pro Gly Leu Asp Leu Val Tyr Ile Val Leu
    450                 455                 460                 
Tyr Leu Asp Asn Gln Leu Ser Ser Pro Tyr Ser Ala Trp Gln His Met
465                 470                 475                 480 
Gly Gln Pro Val Phe Pro Ser Ala Glu Gln Phe Arg Arg Met Arg Met
                485                 490                 495     
Val Glu Asp Pro Val Ala Glu Ala Pro Arg Pro Phe Pro Ala Arg Gly
            500                 505                 510         
Arg Leu Thr Leu His Arg Lys Leu Pro Val Pro Ser Leu Leu Leu Val
        515                 520                 525             
His Val Cys Thr Arg Pro Leu Lys Pro Pro Gly Gln Val Ser Arg Leu
    530                 535                 540                 
Arg Ala Leu Pro Leu Thr His Gly Gln Leu Ile Leu Val Trp Ser Asp
545                 550                 555                 560 
Glu Arg Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser
                565                 570                 575     
Gln Lys Gly Glu Glu Tyr Ala Pro Ile Asn Arg Arg Pro Ser Thr Phe
            580                 585                 590         
Asn Leu Phe Val Phe Ser Pro Asp Thr Ala Val Val Ser Gly Ser Tyr
        595                 600                 605             
Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp
    610                 615                 620                 
Pro Val Thr Tyr Leu Asp Val Pro Ala Ser
625                 630                 


<210> 19
<211> 653
<212> PRT
<213> Homo sapiens

<400> 19
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser
 1               5                  10                  15      
Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val
            20                  25                  30          
His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg
        35                  40                  45              
Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr
    50                  55                  60                  
Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val
65                  70                  75                  80  
Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu
                85                  90                  95      
Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr
            100                 105                 110         
His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro
        115                 120                 125             
Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu
    130                 135                 140                 
Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala
145                 150                 155                 160 
Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn
                165                 170                 175     
Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser
            180                 185                 190         
Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly
        195                 200                 205             
Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser
    210                 215                 220                 
Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His
225                 230                 235                 240 
Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu
                245                 250                 255     
Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile
            260                 265                 270         
Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro
        275                 280                 285             
Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val
    290                 295                 300                 
Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala
305                 310                 315                 320 
Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn
                325                 330                 335     
Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe
            340                 345                 350         
Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg
        355                 360                 365             
Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys
    370                 375                 380                 
Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln
385                 390                 395                 400 
Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His
                405                 410                 415     
Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp
            420                 425                 430         
Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala
        435                 440                 445             
His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro
    450                 455                 460                 
Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu
465                 470                 475                 480 
Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro
                485                 490                 495     
Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala
            500                 505                 510         
Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro
        515                 520                 525             
Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro
    530                 535                 540                 
Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr
545                 550                 555                 560 
Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys
                565                 570                 575     
Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr
            580                 585                 590         
Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser
        595                 600                 605             
Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp
    610                 615                 620                 
Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu
625                 630                 635                 640 
Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro
                645                 650             


<210> 20
<211> 354
<212> PRT
<213> Mus musculus

<400> 20
Met Leu Ser Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Leu Arg Lys
 1               5                  10                  15      
Gly His Thr Ser Val Val Arg His Phe Trp Cys Gly Lys Pro Val Gln
            20                  25                  30          
Ser Gln Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe
        35                  40                  45              
Thr Gly Glu Glu Ile Gln Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys
    50                  55                  60                  
Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys
65                  70                  75                  80  
Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser
                85                  90                  95      
Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Ser Phe Leu Thr
            100                 105                 110         
Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala
        115                 120                 125             
Arg Val Leu Ser Ser Met Thr Asp Ala Val Leu Ala Arg Val Tyr Lys
    130                 135                 140                 
Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Val
145                 150                 155                 160 
Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr
                165                 170                 175     
Leu Thr Leu Gln Glu His Tyr Gly Ser Leu Lys Gly Leu Thr Leu Ser
            180                 185                 190         
Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala
        195                 200                 205             
Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu
    210                 215                 220                 
Pro Asp Pro Asn Ile Val Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn
225                 230                 235                 240 
Gly Thr Lys Leu Ser Met Thr Asn Asp Pro Leu Glu Ala Ala Arg Gly
                245                 250                 255     
Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Asp
            260                 265                 270         
Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met
        275                 280                 285             
Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu
    290                 295                 300                 
Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg
305                 310                 315                 320 
Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala
                325                 330                 335     
Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Val Leu Gln Lys Pro
            340                 345                 350         
Lys Phe
        


<210> 21
<211> 419
<212> PRT
<213> Mus musculus

<400> 21
Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile Gln Asn
 1               5                  10                  15      
Leu Pro Tyr Gly Val Phe Ser Thr Gln Ser Asn Pro Lys Pro Arg Ile
            20                  25                  30          
Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Val Ile Lys His
        35                  40                  45              
Leu Phe Thr Gly Pro Ala Leu Ser Lys His Gln His Val Phe Asp Glu
    50                  55                  60                  
Thr Thr Leu Asn Asn Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu
65                  70                  75                  80  
Ala Arg Ala Ser Leu Gln Asn Leu Leu Ser Ala Ser Gln Ala Arg Leu
                85                  90                  95      
Arg Asp Asp Lys Glu Leu Arg Gln Arg Ala Phe Thr Ser Gln Ala Ser
            100                 105                 110         
Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr
        115                 120                 125             
Ser Ser Arg Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Gly Lys
    130                 135                 140                 
Glu Asn Ala Leu Leu Pro Asn Trp Leu His Leu Pro Val Gly Tyr His
145                 150                 155                 160 
Gly Arg Ala Ser Ser Ile Val Val Ser Gly Thr Pro Ile Arg Arg Pro
                165                 170                 175     
Met Gly Gln Met Arg Pro Asp Asn Ser Lys Pro Pro Val Tyr Gly Ala
            180                 185                 190         
Cys Arg Leu Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro
        195                 200                 205             
Gly Asn Arg Phe Gly Glu Pro Ile Pro Ile Ser Lys Ala His Glu His
    210                 215                 220                 
Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln
225                 230                 235                 240 
Gln Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly
                245                 250                 255     
Thr Thr Ile Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe
            260                 265                 270         
Val Val Pro Asn Pro Lys Gln Asp Pro Lys Pro Leu Pro Tyr Leu Cys
        275                 280                 285             
His Ser Gln Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Ser Leu Lys
    290                 295                 300                 
Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Arg Ser Asn Phe Lys
305                 310                 315                 320 
His Met Tyr Trp Thr Met Leu Gln Gln Leu Thr His His Ser Val Asn
                325                 330                 335     
Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser
            340                 345                 350         
Gly Ser Asp Pro Glu Ser Phe Gly Ser Met Leu Glu Leu Ser Trp Lys
        355                 360                 365             
Gly Thr Lys Ala Ile Asp Val Glu Gln Gly Gln Thr Arg Thr Phe Leu
    370                 375                 380                 
Leu Asp Gly Asp Glu Val Ile Ile Thr Gly His Cys Gln Gly Asp Gly
385                 390                 395                 400 
Tyr Arg Val Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu
                405                 410                 415     
Ser Pro Ala
            


<210> 22
<211> 1983
<212> PRT
<213> Homo sapiens

<400> 22
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val
 1               5                  10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Glu Thr Glu Ile Ala Val Gln Ala
            660                 665                 670         
Lys Gln Pro Asp Val Glu Glu Ile Leu Ser Lys Gly Gln His Leu Tyr
        675                 680                 685             
Lys Glu Lys Pro Ala Thr Gln Pro Val Lys Arg Lys Leu Glu Asp Leu
    690                 695                 700                 
Ser Ser Glu Trp Lys Ala Val Asn Arg Leu Leu Gln Glu Leu Arg Ala
705                 710                 715                 720 
Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro
                725                 730                 735     
Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr
            740                 745                 750         
Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro
        755                 760                 765             
Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr Glu Leu Thr Asp Trp Leu
    770                 775                 780                 
Ser Leu Leu Asp Gln Val Ile Lys Ser Gln Arg Val Met Val Gly Asp
785                 790                 795                 800 
Leu Glu Asp Ile Asn Glu Met Ile Ile Lys Gln Lys Ala Thr Met Gln
                805                 810                 815     
Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala
            820                 825                 830         
Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln Glu Ala Arg Thr Ile Ile
        835                 840                 845             
Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln Trp Asp Glu Val Gln Glu
    850                 855                 860                 
His Leu Gln Asn Arg Arg Gln Gln Leu Asn Glu Met Leu Lys Asp Ser
865                 870                 875                 880 
Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala Glu Gln Val Leu Gly Gln
                885                 890                 895     
Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu Gly Pro Tyr Thr Val Asp
            900                 905                 910         
Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys Gln Leu Ala Lys Asp Leu
        915                 920                 925             
Arg Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys
    930                 935                 940                 
Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr Arg Lys Val His Met Ile
945                 950                 955                 960 
Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser Ile His Lys Arg Val Ser
                965                 970                 975     
Glu Arg Glu Ala Ala Leu Glu Glu Thr His Arg Leu Leu Gln Gln Phe
            980                 985                 990         
Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr
        995                 1000                1005            
Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg Leu Leu Glu
    1010                1015                1020                
Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln Asp Leu Gln
1025                1030                1035               1040 
Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu Asp Glu Asn
                1045                1050                1055    
Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu
            1060                1065                1070        
Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser Glu Leu Arg
        1075                1080                1085            
Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser Ser Asp Gln
    1090                1095                1100                
Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln
1105                1110                1115               1120 
Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly Gly Asp Phe
                1125                1130                1135    
Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe Lys Arg Glu
            1140                1145                1150        
Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg
        1155                1160                1165            
Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys Leu Tyr Gln
    1170                1175                1180                
Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn Val Thr Arg
1185                1190                1195               1200 
Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys Leu
                1205                1210                1215    
Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu Thr Leu Glu
            1220                1225                1230        
Arg Leu Arg Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu
        1235                1240                1245            
Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu
    1250                1255                1260                
Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg
1265                1270                1275               1280 
Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val Asn Asp Leu
                1285                1290                1295    
Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu
            1300                1305                1310        
Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala
        1315                1320                1325            
Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg Asp Phe Gly
    1330                1335                1340                
Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu
1345                1350                1355               1360 
Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr
                1365                1370                1375    
Gln Thr Thr Cys Trp Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser
            1380                1385                1390        
Leu Ala Asp Leu Asn Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met
        1395                1400                1405            
Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu
    1410                1415                1420                
Ser Ala Ala Cys Asp Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp
1425                1430                1435               1440 
Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr
                1445                1450                1455    
Asp Arg Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys
            1460                1465                1470        
Val Asp Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg
        1475                1480                1485            
Thr Gly Arg Ile Arg Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu
    1490                1495                1500                
Cys Lys Ala His Leu Glu Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val
1505                1510                1515               1520 
Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu
                1525                1530                1535    
His Asp Ser Ile Gln Ile Pro Arg Gln Leu Gly Glu Val Ala Ser Phe
            1540                1545                1550        
Gly Gly Ser Asn Ile Glu Pro Ser Val Arg Ser Cys Phe Gln Phe Ala
        1555                1560                1565            
Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg
    1570                1575                1580                
Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg Val Ala
1585                1590                1595               1600 
Ala Ala Glu Thr Ala Lys His Gln Ala Lys Cys Asn Ile Cys Lys Glu
                1605                1610                1615    
Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr
            1620                1625                1630        
Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg Val Ala Lys Gly His
        1635                1640                1645            
Lys Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly
    1650                1655                1660                
Glu Asp Val Arg Asp Phe Ala Lys Val Leu Lys Asn Lys Phe Arg Thr
1665                1670                1675               1680 
Lys Arg Tyr Phe Ala Lys His Pro Arg Met Gly Tyr Leu Pro Val Gln
                1685                1690                1695    
Thr Val Leu Glu Gly Asp Asn Met Glu Thr Pro Val Thr Leu Ile Asn
            1700                1705                1710        
Phe Trp Pro Val Asp Ser Ala Pro Ala Ser Ser Pro Gln Leu Ser His
        1715                1720                1725            
Asp Asp Thr His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu
    1730                1735                1740                
Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn
1745                1750                1755               1760 
Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser
                1765                1770                1775    
Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile
            1780                1785                1790        
Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu
        1795                1800                1805            
Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg
    1810                1815                1820                
Leu Lys Gln Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro
1825                1830                1835               1840 
Pro Glu Met Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu
                1845                1850                1855    
Ile Ala Glu Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala
            1860                1865                1870        
Arg Met Gln Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu
        1875                1880                1885            
His Arg Leu Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val
    1890                1895                1900                
Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp
1905                1910                1915               1920 
Ser Ser Gln Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp
                1925                1930                1935    
Ser Met Gly Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr
            1940                1945                1950        
Gly Leu Glu Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser
        1955                1960                1965            
Arg Gly Arg Asn Thr Pro Gly Lys Pro Met Arg Glu Asp Thr Met
    1970                1975                1980            


<210> 23
<211> 3685
<212> PRT
<213> Homo sapiens

<400> 23
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val
 1               5                  10                  15      
Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe
            20                  25                  30          
Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg
        35                  40                  45              
Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys
    50                  55                  60                  
Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala
65                  70                  75                  80  
Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser
                85                  90                  95      
Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp
            100                 105                 110         
Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met
        115                 120                 125             
Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val
    130                 135                 140                 
Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr
145                 150                 155                 160 
Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His
                165                 170                 175     
Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala
            180                 185                 190         
Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly
        195                 200                 205             
Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp
    210                 215                 220                 
Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro
225                 230                 235                 240 
Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg
                245                 250                 255     
Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met
            260                 265                 270         
His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg
        275                 280                 285             
Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala
    290                 295                 300                 
Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln
305                 310                 315                 320 
His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu
                325                 330                 335     
Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu
            340                 345                 350         
Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile
        355                 360                 365             
Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly
    370                 375                 380                 
Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu
385                 390                 395                 400 
Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu
                405                 410                 415     
Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu
            420                 425                 430         
Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val
        435                 440                 445             
Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu
    450                 455                 460                 
Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly
465                 470                 475                 480 
Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu
                485                 490                 495     
Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His
            500                 505                 510         
Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala
        515                 520                 525             
Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys
    530                 535                 540                 
Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys
545                 550                 555                 560 
Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser
                565                 570                 575     
Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp
            580                 585                 590         
Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala
        595                 600                 605             
Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys
    610                 615                 620                 
Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr
625                 630                 635                 640 
Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln
                645                 650                 655     
Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr
            660                 665                 670         
Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val
        675                 680                 685             
Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro
    690                 695                 700                 
Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile
705                 710                 715                 720 
Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr
                725                 730                 735     
Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys
            740                 745                 750         
Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg
        755                 760                 765             
Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala
    770                 775                 780                 
Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser
785                 790                 795                 800 
Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys
                805                 810                 815     
Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile
            820                 825                 830         
Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr
        835                 840                 845             
Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr
    850                 855                 860                 
Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu
865                 870                 875                 880 
Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala
                885                 890                 895     
Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val
            900                 905                 910         
Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg
        915                 920                 925             
Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr
    930                 935                 940                 
Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr
945                 950                 955                 960 
Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu
                965                 970                 975     
Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln
            980                 985                 990         
Gln Ser Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys Glu Met Ser Lys
        995                 1000                1005            
Lys Ala Pro Ser Glu Ile Ser Arg Lys Tyr Gln Ser Glu Phe Glu Glu
    1010                1015                1020                
Ile Glu Gly Arg Trp Lys Lys Leu Ser Ser Gln Leu Val Glu His Cys
1025                1030                1035               1040 
Gln Lys Leu Glu Glu Gln Met Asn Lys Leu Arg Lys Ile Gln Asn His
                1045                1050                1055    
Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp Val Phe Leu Lys
            1060                1065                1070        
Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys Gln Leu
        1075                1080                1085            
Lys Gln Cys Arg Leu Leu Val Ser Asp Ile Gln Thr Ile Gln Pro Ser
    1090                1095                1100                
Leu Asn Ser Val Asn Glu Gly Gly Gln Lys Ile Lys Asn Glu Ala Glu
1105                1110                1115               1120 
Pro Glu Phe Ala Ser Arg Leu Glu Thr Glu Leu Lys Glu Leu Asn Thr
                1125                1130                1135    
Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala Arg Lys Glu Ala Leu
            1140                1145                1150        
Lys Gly Gly Leu Glu Lys Thr Val Ser Leu Gln Lys Asp Leu Ser Glu
        1155                1160                1165            
Met His Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr Leu Glu Arg Asp
    1170                1175                1180                
Phe Glu Tyr Lys Thr Pro Asp Glu Leu Gln Lys Ala Val Glu Glu Met
1185                1190                1195               1200 
Lys Arg Ala Lys Glu Glu Ala Gln Gln Lys Glu Ala Lys Val Lys Leu
                1205                1210                1215    
Leu Thr Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val Ala
            1220                1225                1230        
Gln Glu Ala Leu Lys Lys Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln
        1235                1240                1245            
Trp Leu Cys Thr Arg Leu Asn Gly Lys Cys Lys Thr Leu Glu Glu Val
    1250                1255                1260                
Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu Glu Lys Ala Asn Lys
1265                1270                1275               1280 
Trp Leu Asn Glu Val Glu Phe Lys Leu Lys Thr Thr Glu Asn Ile Pro
                1285                1290                1295    
Gly Gly Ala Glu Glu Ile Ser Glu Val Leu Asp Ser Leu Glu Asn Leu
            1300                1305                1310        
Met Arg His Ser Glu Asp Asn Pro Asn Gln Ile Arg Ile Leu Ala Gln
        1315                1320                1325            
Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu Ile Asn Glu Glu Leu
    1330                1335                1340                
Glu Thr Phe Asn Ser Arg Trp Arg Glu Leu His Glu Glu Ala Val Arg
1345                1350                1355               1360 
Arg Gln Lys Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu
                1365                1370                1375    
Lys Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys Gln
            1380                1385                1390        
Leu Ala Ala Tyr Ile Ala Asp Lys Val Asp Ala Ala Gln Met Pro Gln
        1395                1400                1405            
Glu Ala Gln Lys Ile Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu
    1410                1415                1420                
Glu Glu Met Lys Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val
1425                1430                1435               1440 
Leu Ser Gln Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met
                1445                1450                1455    
Lys Phe Arg Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln
            1460                1465                1470        
Glu Ser Lys Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu
        1475                1480                1485            
Glu Thr Lys Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His
    1490                1495                1500                
Cys Val Asn Leu Tyr Lys Ser Leu Ser Glu Val Lys Ser Glu Val Glu
1505                1510                1515               1520 
Met Val Ile Lys Thr Gly Arg Gln Ile Val Gln Lys Lys Gln Thr Glu
                1525                1530                1535    
Asn Pro Lys Glu Leu Asp Glu Arg Val Thr Ala Leu Lys Leu His Tyr
            1540                1545                1550        
Asn Glu Leu Gly Ala Lys Val Thr Glu Arg Lys Gln Gln Leu Glu Lys
        1555                1560                1565            
Cys Leu Lys Leu Ser Arg Lys Met Arg Lys Glu Met Asn Val Leu Thr
    1570                1575                1580                
Glu Trp Leu Ala Ala Thr Asp Met Glu Leu Thr Lys Arg Ser Ala Val
1585                1590                1595               1600 
Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp Gly Lys Ala
                1605                1610                1615    
Thr Gln Lys Glu Ile Glu Lys Gln Lys Val His Leu Lys Ser Ile Thr
            1620                1625                1630        
Glu Val Gly Glu Ala Leu Lys Thr Val Leu Gly Lys Lys Glu Thr Leu
        1635                1640                1645            
Val Glu Asp Lys Leu Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr
    1650                1655                1660                
Ser Arg Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys His
1665                1670                1675               1680 
Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys Trp Ile Ile
                1685                1690                1695    
Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys Lys Lys Pro Gln Gln
            1700                1705                1710        
Lys Glu Asp Val Leu Lys Arg Leu Lys Ala Glu Leu Asn Asp Ile Arg
        1715                1720                1725            
Pro Lys Val Asp Ser Thr Arg Asp Gln Ala Ala Asn Leu Met Ala Asn
    1730                1735                1740                
Arg Gly Asp His Cys Arg Lys Leu Val Glu Pro Gln Ile Ser Glu Leu
1745                1750                1755               1760 
Asn His Arg Phe Ala Ala Ile Ser His Arg Ile Lys Thr Gly Lys Ala
                1765                1770                1775    
Ser Ile Pro Leu Lys Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys
            1780                1785                1790        
Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys
        1795                1800                1805            
Glu Glu Asp Phe Asn Lys Asp Met Asn Glu Asp Asn Glu Gly Thr Val
    1810                1815                1820                
Lys Glu Leu Leu Gln Arg Gly Asp Asn Leu Gln Gln Arg Ile Thr Asp
1825                1830                1835               1840 
Glu Arg Lys Arg Glu Glu Ile Lys Ile Lys Gln Gln Leu Leu Gln Thr
                1845                1850                1855    
Lys His Asn Ala Leu Lys Asp Leu Arg Ser Gln Arg Arg Lys Lys Ala
            1860                1865                1870        
Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys Arg Gln Ala Asp Asp
        1875                1880                1885            
Leu Leu Lys Cys Leu Asp Asp Ile Glu Lys Lys Leu Ala Ser Leu Pro
    1890                1895                1900                
Glu Pro Arg Asp Glu Arg Lys Ile Lys Glu Ile Asp Arg Glu Leu Gln
1905                1910                1915               1920 
Lys Lys Lys Glu Glu Leu Asn Ala Val Arg Arg Gln Ala Glu Gly Leu
                1925                1930                1935    
Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro Thr Gln Ile Gln Leu
            1940                1945                1950        
Ser Lys Arg Trp Arg Glu Ile Glu Ser Lys Phe Ala Gln Phe Arg Arg
        1955                1960                1965            
Leu Asn Phe Ala Gln Ile His Thr Val Arg Glu Glu Thr Met Met Val
    1970                1975                1980                
Met Thr Glu Asp Met Pro Leu Glu Ile Ser Tyr Val Pro Ser Thr Tyr
1985                1990                1995               2000 
Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln
                2005                2010                2015    
Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp Phe Glu Asp Leu Phe
            2020                2025                2030        
Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp Ser Leu Gln Gln Ser
        2035                2040                2045            
Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys Thr Ala Ala Leu Gln
    2050                2055                2060                
Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln Glu Ala Leu Ser Gln
2065                2070                2075               2080 
Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met Tyr Lys Asp Arg Gln
                2085                2090                2095    
Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg Arg Phe His Tyr Asp
            2100                2105                2110        
Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg
        2115                2120                2125            
Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys Tyr Lys Trp Tyr
    2130                2135                2140                
Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg Gln Thr Val Val Arg
2145                2150                2155               2160 
Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys Thr
                2165                2170                2175    
Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser Leu Asn Leu Arg Trp
            2180                2185                2190        
Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys Lys Arg Leu Glu Glu
        2195                2200                2205            
Gln Lys Asn Ile Leu Ser Glu Phe Gln Arg Asp Leu Asn Glu Phe Val
    2210                2215                2220                
Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala Ser Ile Pro Leu Glu Pro
2225                2230                2235               2240 
Gly Lys Glu Gln Gln Leu Lys Glu Lys Leu Glu Gln Val Lys Leu Leu
                2245                2250                2255    
Val Glu Glu Leu Pro Leu Arg Gln Gly Ile Leu Lys Gln Leu Asn Glu
            2260                2265                2270        
Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser Pro Glu Glu Gln
        2275                2280                2285            
Asp Lys Leu Glu Asn Lys Leu Lys Gln Thr Asn Leu Gln Trp Ile Lys
    2290                2295                2300                
Val Ser Arg Ala Leu Pro Glu Lys Gln Gly Glu Ile Glu Ala Gln Ile
2305                2310                2315               2320 
Lys Asp Leu Gly Gln Leu Glu Lys Lys Leu Glu Asp Leu Glu Glu Gln
                2325                2330                2335    
Leu Asn His Leu Leu Leu Trp Leu Ser Pro Ile Arg Asn Gln Leu Glu
            2340                2345                2350        
Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp Val Lys Glu Thr
        2355                2360                2365            
Glu Ile Ala Val Gln Ala Lys Gln Pro Asp Val Glu Glu Ile Leu Ser
    2370                2375                2380                
Lys Gly Gln His Leu Tyr Lys Glu Lys Pro Ala Thr Gln Pro Val Lys
2385                2390                2395               2400 
Arg Lys Leu Glu Asp Leu Ser Ser Glu Trp Lys Ala Val Asn Arg Leu
                2405                2410                2415    
Leu Gln Glu Leu Arg Ala Lys Gln Pro Asp Leu Ala Pro Gly Leu Thr
            2420                2425                2430        
Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro
        2435                2440                2445            
Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu Glu Met Pro Ser Ser
    2450                2455                2460                
Leu Met Leu Glu Val Pro Ala Leu Ala Asp Phe Asn Arg Ala Trp Thr
2465                2470                2475               2480 
Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile Lys Ser Gln
                2485                2490                2495    
Arg Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys
            2500                2505                2510        
Gln Lys Ala Thr Met Gln Asp Leu Glu Gln Arg Arg Pro Gln Leu Glu
        2515                2520                2525            
Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys Asn Lys Thr Ser Asn Gln
    2530                2535                2540                
Glu Ala Arg Thr Ile Ile Thr Asp Arg Ile Glu Arg Ile Gln Asn Gln
2545                2550                2555               2560 
Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg Arg Gln Gln Leu Asn
                2565                2570                2575    
Glu Met Leu Lys Asp Ser Thr Gln Trp Leu Glu Ala Lys Glu Glu Ala
            2580                2585                2590        
Glu Gln Val Leu Gly Gln Ala Arg Ala Lys Leu Glu Ser Trp Lys Glu
        2595                2600                2605            
Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys Lys Ile Thr Glu Thr Lys
    2610                2615                2620                
Gln Leu Ala Lys Asp Leu Arg Gln Trp Gln Thr Asn Val Asp Val Ala
2625                2630                2635               2640 
Asn Asp Leu Ala Leu Lys Leu Leu Arg Asp Tyr Ser Ala Asp Asp Thr
                2645                2650                2655    
Arg Lys Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg Ser
            2660                2665                2670        
Ile His Lys Arg Val Ser Glu Arg Glu Ala Ala Leu Glu Glu Thr His
        2675                2680                2685            
Arg Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp
    2690                2695                2700                
Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg
2705                2710                2715               2720 
Lys Glu Arg Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys
                2725                2730                2735    
Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr
            2740                2745                2750        
His Asn Leu Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly
        2755                2760                2765            
Ser Asp Asp Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe
    2770                2775                2780                
Lys Trp Ser Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu
2785                2790                2795               2800 
Glu Ala Ser Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu
                2805                2810                2815    
Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala
            2820                2825                2830        
Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His
        2835                2840                2845            
Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser
    2850                2855                2860                
Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly
2865                2870                2875               2880 
Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg
                2885                2890                2895    
Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn
            2900                2905                2910        
Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys
        2915                2920                2925            
Ile Asp Glu Thr Leu Glu Arg Leu Arg Glu Leu Gln Glu Ala Thr Asp
    2930                2935                2940                
Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp
2945                2950                2955               2960 
Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu
                2965                2970                2975    
Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val
            2980                2985                2990        
Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln
        2995                3000                3005            
Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp
    3010                3015                3020                
Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu
3025                3030                3035               3040 
Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser
                3045                3050                3055    
Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr
            3060                3065                3070        
Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His Pro Lys Met
        3075                3080                3085            
Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg Phe Ser
    3090                3095                3100                
Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys Ala Leu Cys
3105                3110                3115               3120 
Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu Asp Gln His
                3125                3130                3135    
Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn
            3140                3145                3150        
Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu His Asn Asn Leu
        3155                3160                3165            
Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn Trp Leu Leu Asn
    3170                3175                3180                
Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val Leu Ser Phe Lys
3185                3190                3195               3200 
Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu Asp Lys Tyr Arg
                3205                3210                3215    
Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg
            3220                3225                3230        
Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg Gln Leu
        3235                3240                3245            
Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser Val Arg
    3250                3255                3260                
Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile Glu Ala Ala Leu
3265                3270                3275               3280 
Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met Val Trp Leu Pro
                3285                3290                3295    
Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys His Gln Ala Lys
            3300                3305                3310        
Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe Arg Tyr Arg Ser
        3315                3320                3325            
Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly
    3330                3335                3340                
Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu Tyr Cys
3345                3350                3355               3360 
Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys Val Leu
                3365                3370                3375    
Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro Arg Met
            3380                3385                3390        
Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu Thr
        3395                3400                3405            
Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala Ser
    3410                3415                3420                
Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu His Tyr
3425                3430                3435               3440 
Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn
                3445                3450                3455    
Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile
            3460                3465                3470        
Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro
        3475                3480                3485            
Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg Gly
    3490                3495                3500                
Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu
3505                3510                3515               3520 
Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys Gly Leu
                3525                3530                3535    
Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro Gln Ser
            3540                3545                3550        
Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg Gln His
        3555                3560                3565            
Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His Asn Lys
    3570                3575                3580                
Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu Gln Pro
3585                3590                3595               3600 
Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr
                3605                3610                3615    
Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg Val Val
            3620                3625                3630        
Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu Ser Pro
        3635                3640                3645            
Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln Leu Asn
    3650                3655                3660                
Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys Pro Met
3665                3670                3675               3680 
Arg Glu Asp Thr Met
                3685


<210> 24
<211> 393
<212> PRT
<213> Homo sapiens

<400> 24
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln
 1               5                  10                  15      
Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu
            20                  25                  30          
Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp
        35                  40                  45              
Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
    50                  55                  60                  
Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro
65                  70                  75                  80  
Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser
                85                  90                  95      
Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly
            100                 105                 110         
Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro
        115                 120                 125             
Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln
    130                 135                 140                 
Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met
145                 150                 155                 160 
Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
                165                 170                 175     
Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
            180                 185                 190         
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
        195                 200                 205             
Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu
    210                 215                 220                 
Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser
225                 230                 235                 240 
Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr
                245                 250                 255     
Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val
            260                 265                 270         
Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn
        275                 280                 285             
Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
    290                 295                 300                 
Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305                 310                 315                 320 
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu
                325                 330                 335     
Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp
            340                 345                 350         
Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His
        355                 360                 365             
Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met
    370                 375                 380                 
Phe Lys Thr Glu Gly Pro Asp Ser Asp
385                 390             


<210> 25
<211> 403
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr
 1               5                  10                  15      
Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile
            20                  25                  30          
Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn
        35                  40                  45              
Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His
    50                  55                  60                  
Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys
65                  70                  75                  80  
Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro
                85                  90                  95      
Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu
            100                 105                 110         
Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys
        115                 120                 125             
Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys
    130                 135                 140                 
Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr
145                 150                 155                 160 
Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr
                165                 170                 175     
Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala
            180                 185                 190         
Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly
        195                 200                 205             
Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile
    210                 215                 220                 
Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr
225                 230                 235                 240 
Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu
                245                 250                 255     
Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His
            260                 265                 270         
Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu
        275                 280                 285             
Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys
    290                 295                 300                 
Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu
305                 310                 315                 320 
Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr
                325                 330                 335     
Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu
            340                 345                 350         
Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp
        355                 360                 365             
Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp
    370                 375                 380                 
Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile
385                 390                 395                 400 
Thr Lys Val
            


<210> 26
<211> 117
<212> PRT
<213> SARS-CoV-2

<400> 26
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ala Gly Ala His Arg Val
            20                  25                  30          
Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala
        35                  40                  45              
Ile Gly Ala Ser Gly Gly Met Thr Asn Tyr Leu Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala
                85                  90                  95      
Arg Asp Ile Glu Thr Ala Glu Tyr Ile Tyr Trp Gly Gln Gly Thr Gln
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 27
<211> 117
<212> PRT
<213> SARS-CoV-2

<400> 27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Gly Ala His Arg Val
            20                  25                  30          
Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala
        35                  40                  45              
Ile Gly Ala Asn Gly Gly Asn Thr Asn Tyr Leu Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala
                85                  90                  95      
Arg Asp Ile Glu Thr Ala Glu Tyr Thr Tyr Trp Gly Gln Gly Thr Gln
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 28
<211> 403
<212> PRT
<213> SARS-CoV-2

<400> 28
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ala Gly Ala His Arg Val
            20                  25                  30          
Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala
        35                  40                  45              
Ile Gly Ala Ser Gly Gly Met Thr Asn Tyr Leu Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala
                85                  90                  95      
Arg Asp Ile Glu Thr Ala Glu Tyr Ile Tyr Trp Gly Gln Gly Thr Gln
            100                 105                 110         
Val Thr Val Ser Ser Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ala Gly Ala His Arg Val
                165                 170                 175     
Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala
            180                 185                 190         
Ile Gly Ala Ser Gly Gly Met Thr Asn Tyr Leu Asp Ser Val Lys Gly
        195                 200                 205             
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln
    210                 215                 220                 
Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala
225                 230                 235                 240 
Arg Asp Ile Glu Thr Ala Glu Tyr Ile Tyr Trp Gly Gln Gly Thr Gln
                245                 250                 255     
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
            260                 265                 270         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val
        275                 280                 285             
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu
    290                 295                 300                 
Arg Leu Ser Cys Ala Val Ser Gly Ala Gly Ala His Arg Val Gly Trp
305                 310                 315                 320 
Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Gly
                325                 330                 335     
Ala Ser Gly Gly Met Thr Asn Tyr Leu Asp Ser Val Lys Gly Arg Phe
            340                 345                 350         
Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Asn
        355                 360                 365             
Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Asp
    370                 375                 380                 
Ile Glu Thr Ala Glu Tyr Ile Tyr Trp Gly Gln Gly Thr Gln Val Thr
385                 390                 395                 400 
Val Ser Ser
            


<210> 29
<211> 404
<212> PRT
<213> SARS-CoV-2

<400> 29
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Gly Ala His Arg Val
            20                  25                  30          
Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala
        35                  40                  45              
Ile Gly Ala Asn Gly Gly Asn Thr Asn Tyr Leu Asp Ser Val Lys Gly
    50                  55                  60                  
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala
                85                  90                  95      
Arg Asp Ile Glu Thr Ala Glu Tyr Thr Tyr Trp Gly Gln Gly Thr Gln
            100                 105                 110         
Val Thr Val Ser Ser Lys Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Gly Ala His Arg
                165                 170                 175     
Val Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala
            180                 185                 190         
Ala Ile Gly Ala Asn Gly Gly Asn Thr Asn Tyr Leu Asp Ser Val Lys
        195                 200                 205             
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu
    210                 215                 220                 
Gln Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala
225                 230                 235                 240 
Ala Arg Asp Ile Glu Thr Ala Glu Tyr Thr Tyr Trp Gly Gln Gly Thr
                245                 250                 255     
Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
            260                 265                 270         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
        275                 280                 285             
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser
    290                 295                 300                 
Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Gly Ala His Arg Val Gly
305                 310                 315                 320 
Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile
                325                 330                 335     
Gly Ala Asn Gly Gly Asn Thr Asn Tyr Leu Asp Ser Val Lys Gly Arg
            340                 345                 350         
Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met
        355                 360                 365             
Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg
    370                 375                 380                 
Asp Ile Glu Thr Ala Glu Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val
385                 390                 395                 400 
Thr Val Ser Ser
                


<210> 30
<211> 119
<212> PRT
<213> SARS-CoV-2

<400> 30
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Gly Arg Asn
            20                  25                  30          
Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val
        35                  40                  45              
Ala Gly Ile Thr Arg Arg Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Asp Pro Ala Ser Pro Ala Tyr Gly Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Gln Val Thr Val Ser Ser
        115                 


<210> 31
<211> 397
<212> PRT
<213> SARS-CoV-2

<400> 31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ile Phe Gly Arg Asn
            20                  25                  30          
Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val
        35                  40                  45              
Ala Gly Ile Thr Arg Arg Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ala Asp Pro Ala Ser Pro Ala Tyr Gly Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val
    130                 135                 140                 
Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser
145                 150                 155                 160 
Cys Ala Ala Ser Gly Tyr Ile Phe Gly Arg Asn Ala Met Gly Trp Tyr
                165                 170                 175     
Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly Ile Thr Arg
            180                 185                 190         
Arg Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
        195                 200                 205             
Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser
    210                 215                 220                 
Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Pro Ala
225                 230                 235                 240 
Ser Pro Ala Tyr Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val
                245                 250                 255     
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
            260                 265                 270         
Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly
        275                 280                 285             
Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
    290                 295                 300                 
Tyr Ile Phe Gly Arg Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly
305                 310                 315                 320 
Lys Glu Arg Glu Leu Val Ala Gly Ile Thr Arg Arg Gly Ser Ile Thr
                325                 330                 335     
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
            340                 345                 350         
Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp
        355                 360                 365             
Thr Ala Val Tyr Tyr Cys Ala Ala Asp Pro Ala Ser Pro Ala Tyr Gly
    370                 375                 380                 
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser
385                 390                 395         


<210> 32
<211> 455
<212> PRT
<213> SARS-CoV-2

<400> 32
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Thr Thr Tyr
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Asp Gly Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Thr Arg Gly Arg Gly Leu Tyr Asp Tyr Val Trp Gly Ser Lys
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
225                 230                 235                 240 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
                325                 330                 335     
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
        355                 360                 365             
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys
    450                 455 


<210> 33
<211> 219
<212> PRT
<213> SARS-CoV-2

<400> 33
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
            20                  25                  30          
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
                85                  90                  95      
Leu Gln Thr Pro Gly Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 


<210> 34
<211> 167
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Ser Ala Glu Ile Asp Leu Gly Lys Gly Asp Phe Arg Glu Ile Arg Ala
 1               5                  10                  15      
Ser Glu Asp Ala Arg Glu Ala Ala Glu Ala Leu Ala Glu Ala Ala Arg
            20                  25                  30          
Ala Met Lys Glu Ala Leu Glu Ile Ile Arg Glu Ile Ala Glu Lys Leu
        35                  40                  45              
Arg Asp Ser Ser Arg Ala Ser Glu Ala Ala Lys Arg Ile Ala Lys Ala
    50                  55                  60                  
Ile Arg Lys Ala Ala Asp Ala Ile Ala Glu Ala Ala Lys Ile Ala Ala
65                  70                  75                  80  
Arg Ala Ala Lys Asp Gly Asp Ala Ala Arg Asn Ala Glu Asn Ala Ala
                85                  90                  95      
Arg Lys Ala Lys Glu Phe Ala Glu Glu Gln Ala Lys Leu Ala Asp Met
            100                 105                 110         
Tyr Ala Glu Leu Ala Lys Asn Gly Asp Lys Ser Ser Val Leu Glu Gln
        115                 120                 125             
Leu Lys Thr Phe Ala Asp Lys Ala Phe His Glu Met Glu Asp Arg Phe
    130                 135                 140                 
Tyr Gln Ala Ala Leu Ala Val Phe Glu Ala Ala Glu Ala Ala Ala Gly
145                 150                 155                 160 
Gly Ser Gly Trp Gly Ser Gly
                165         


<210> 35
<211> 344
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Ser Ala Glu Ile Asp Leu Gly Lys Gly Asp Phe Arg Glu Ile Arg Ala
 1               5                  10                  15      
Ser Glu Asp Ala Arg Glu Ala Ala Glu Ala Leu Ala Glu Ala Ala Arg
            20                  25                  30          
Ala Met Lys Glu Ala Leu Glu Ile Ile Arg Glu Ile Ala Glu Lys Leu
        35                  40                  45              
Arg Asp Ser Ser Arg Ala Ser Glu Ala Ala Lys Arg Ile Ala Lys Ala
    50                  55                  60                  
Ile Arg Lys Ala Ala Asp Ala Ile Ala Glu Ala Ala Lys Ile Ala Ala
65                  70                  75                  80  
Arg Ala Ala Lys Asp Gly Asp Ala Ala Arg Asn Ala Glu Asn Ala Ala
                85                  90                  95      
Arg Lys Ala Lys Glu Phe Ala Glu Glu Gln Ala Lys Leu Ala Asp Met
            100                 105                 110         
Tyr Ala Glu Leu Ala Lys Asn Gly Asp Lys Ser Ser Val Leu Glu Gln
        115                 120                 125             
Leu Lys Thr Phe Ala Asp Lys Ala Phe His Glu Met Glu Asp Arg Phe
    130                 135                 140                 
Tyr Gln Ala Ala Leu Ala Val Phe Glu Ala Ala Glu Ala Ala Ala Gly
145                 150                 155                 160 
Gly Gly Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly Gly Ser
                165                 170                 175     
Pro Gly Ser Ala Glu Ile Asp Leu Gly Lys Gly Asp Phe Arg Glu Ile
            180                 185                 190         
Arg Ala Ser Glu Asp Ala Arg Glu Ala Ala Glu Ala Leu Ala Glu Ala
        195                 200                 205             
Ala Arg Ala Met Lys Glu Ala Leu Glu Ile Ile Arg Glu Ile Ala Glu
    210                 215                 220                 
Lys Leu Arg Asp Ser Ser Arg Ala Ser Glu Ala Ala Lys Arg Ile Ala
225                 230                 235                 240 
Lys Ala Ile Arg Lys Ala Ala Asp Ala Ile Ala Glu Ala Ala Lys Ile
                245                 250                 255     
Ala Ala Arg Ala Ala Lys Asp Gly Asp Ala Ala Arg Asn Ala Glu Asn
            260                 265                 270         
Ala Ala Arg Lys Ala Lys Glu Phe Ala Glu Glu Gln Ala Lys Leu Ala
        275                 280                 285             
Asp Met Tyr Ala Glu Leu Ala Lys Asn Gly Asp Lys Ser Ser Val Leu
    290                 295                 300                 
Glu Gln Leu Lys Thr Phe Ala Asp Lys Ala Phe His Glu Met Glu Asp
305                 310                 315                 320 
Arg Phe Tyr Gln Ala Ala Leu Ala Val Phe Glu Ala Ala Glu Ala Ala
                325                 330                 335     
Ala Gly Gly Ser Gly Trp Gly Ser
            340                 


<210> 36
<211> 9
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
gccaccaug                                                         9

<210> 37
<211> 51
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
gaaaaacaaa aaacaaaaaa aacaaaaaaa aaaccaaaaa aacaaaacac a          51

<210> 38
<211> 27
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
acgaguccug gacugaaacg gacuugu                                     27

<210> 39
<211> 52
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
aaaauccguu gaccuuaaac ggucgugugg guucaagucc cuccaccccc ac         52

<210> 40
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
gagacgcuac ggacuu                                                 16

<210> 41
<211> 33
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
gggagacccu cgaccgucga uuguccacug guc                              33

<210> 42
<211> 35
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
accaguggac aaucgacgga uaacagcaua ucuag                            35

<210> 43
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
uaauacgacu cacuauagg                                              19

<210> 44
<211> 54
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
gagggcagag gaagucuucu aacaugcggu gacguggagg agaaucccgg cccu       54

<210> 45
<211> 57
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
gcuacuaacu ucagccugcu gaagcaggcu ggagacgugg aggagaaccc uggaccu    57

<210> 46
<211> 131
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
aacaauagau gacuuacaac uaaucggaag gugcagagac ucgacgggag cuacccuaac 60
gucaagacga ggguaaagag agaguccaau ucucaaagcc aauaggcagu agcgaaagcu 120
gcaagagaau g                                                      131

<210> 47
<211> 116
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
aaauaauuga gccuuaaaga agaaauucuu uaaguggaug cucucaaacu cagggaaacc 60
uaaaucuagu uauagacaag gcaauccuga gccaagccga aguaguaauu aguaag     116

<210> 48
<211> 3819
<212> RNA
<213> SARS-CoV-2

<400> 48
auguucguuu uccuuguucu guugccucuc guuaguagcc aaugcgucaa ccuuacuacu 60
agaacccagc ucccuccagc auauaccaac ucuuucacca ggggcguaua uuacccggac 120
aaaguguucc gcucaagugu gcugcauucu acgcaggacc uuuucuugcc cuuuuucagu 180
aauguuacuu gguuucaugc uauccaugug ucuggaacua acggaaccaa gcgcuuugac 240
aaccccgucc ucccuuucaa cgauggcgug uacuucgcuu ccacggaaaa gucaaacaua 300
auucgcggcu ggaucuuugg uacaacacuc gacucaaaga cgcagagccu gcugaucguu 360
aauaacgcua caaauguugu gauaaaggug ugugaauuuc aguucugcaa ugaucccuuc 420
cugggugugu acuaccauaa gaauaacaag agcuggaugg aauccgaauu uaggguuuac 480
aguuccgcua acaacugcac auucgaauac guaagccagc cauuucuuau ggaucuugag 540
ggcaagcaag gaaacuucaa gaacuugagg gaguucgugu ucaaaaauau cgacggcuau 600
uuuaagauau auagcaagca cacuccaaua aacuuggugc gcgaccugcc ccagggauuc 660
ucugcucugg agccccuggu ggaucugccc auuggaauaa acauaacucg cuuucaaaca 720
cugcucgccc ugcaucgcag uuaccucacc ccuggugaua guaguucagg auggacagca 780
ggagccgccg cauacuacgu cggcuaccug cagccuagga ccuucuugcu gaaguacaac 840
gagaacggua caauaacuga cgcuguggac ugcgcucugg acccucuguc cgagacgaag 900
ugcacccuga agagcuuuac uguugaaaaa ggcauuuacc aaaccagcaa cuuccgcguc 960
cagccaaccg agagcaucgu cagauuuccc aacauuacaa aucugugucc cuucggcgag 1020
guguucaacg ccacacgcuu cgcuucagug uacgcaugga accgcaagcg cauaucuaac 1080
ugcgucgcgg auuauucugu ccucuacaac uccgccucuu ucuccaccuu caagugcuac 1140
ggagugucac cgacuaagcu gaacgaucuc ugcuuuacca acgucuacgc ggacuccuuc 1200
gugauaagag gugaugaagu gagacaaaua gccccagguc agacugguaa gaucgcagau 1260
uacaacuaca aauugccuga ugauuucacu gguugcguua ucgcguggaa cucuaauaac 1320
cucgauucua aggucggugg uaacuacaau uaccuguacc gcuuguuuag gaagucaaac 1380
cugaagccuu ucgagaggga uauuucaacc gaaaucuauc aagcggguuc aacaccgugu 1440
aacggugugg aaggauuuaa cugcuacuuc ccccugcagu cuuacggauu ccagccaacc 1500
aauggcgugg guuaccaacc uuaucgcgug gugguucuga guuucgaacu guugcacgcu 1560
cccgccacgg uaugcggucc caagaagagc acuaacuugg ugaagaauaa gugcgugaau 1620
uucaauuuca auggccucac uggaacugga gugcugaccg aauccaauaa gaaguucuug 1680
cccuuccagc aguucggaag agacauugcu gacacaaccg acgcggugcg cgauccucag 1740
acucuggaga uauuggacau uacaccaugu ucuuucggcg gugugucugu cauuacuccg 1800
ggcacgaaua cuagcaacca gguagccgug cuguaccaag acgugaauug cacagagguu 1860
cccgucgcaa uucacgcuga ccagcugacc cccacgugga ggguuuacag cacugguagu 1920
aacgucuucc agacgagagc cgguugcuug aucggagcgg aacaugugaa uaacuccuac 1980
gagugcgaca uccccaucgg agccgguaua ugcgccucuu aucagacaca aacuaacuca 2040
cccaggagag cccgcagugu ggcuucucaa agcauuauag cauacacuau gucucuuggu 2100
gccgaaaauu ccguggccua uucuaacaau ucaaucgcca ucccaaccaa cuucacaauu 2160
agcgugacua ccgaaauacu gccugugagc augacgaaaa ccagcguaga cugcacuaug 2220
uauaucugug gagacuccac ugagugcucc aaccuucucc ugcaguacgg uagcuucugu 2280
acccaauuga accgcgcccu uacaggcauc gcuguugagc aagauaagaa uacccaggaa 2340
guuuuugccc agguuaagca gauauacaaa acaccgccca uuaaggacuu cggaggcuuc 2400
aacuucucuc agauacugcc ugaccccucc aagccaucaa aacgcagcuu cauugaggac 2460
cucuuguuca acaaagugac ucuggcugau gcuggcuuca uuaagcagua cggagauugc 2520
cugggagaua uugcugccag ggaccucauc ugcgcccaga aguuuaaugg ccugacaguc 2580
uugcccccac uucugacaga cgagaugauu gcucaguaca caucugcccu ccucgcuggc 2640
accauaacau ccggauggac auuuggugcu ggugcugccc uccagauucc cuucgcaaug 2700
cagauggcgu aucgcuuuaa cggcaucggu gucacacaaa acguguugua ugagaaccaa 2760
aagcucaucg cuaaccaguu uaauucugcu auugguaaga uucaggacag ccugucauca 2820
accgcgucug cccuugguaa guugcaggac guggugaacc agaaugcuca ggcuuugaau 2880
acucugguga agcaacucuc uucaaauuuc ggcgcuaucu cuucuguguu gaacgacauc 2940
cugagucgcc uugauaaggu ggaagcugaa guucaaauug auagauugau uacuggcagg 3000
cuccagucuu ugcagaccua cguuacacag cagcugauua gggcggcuga aauuagagcu 3060
uccgccaauc uggcugcaac caagaugucc gaaugcgucc ugggucaguc aaagcgcguu 3120
gacuuuugug guaaaggcua ccaccucaug ucauuucccc agucagcacc ucacggagua 3180
guguuccucc acgucaccua cguuccagca caggaaaaga auuuuaccac ugcgccggca 3240
aucugucacg acgguaaggc acacuucccc cgcgagggcg uauucguguc uaacggaacu 3300
cauugguucg ucacacagag aaacuucuau gagccucaga ucauuaccac cgacaauaca 3360
uuuguguccg guaacugcga cguugugauu ggaaucguca acaacacugu guacgaucca 3420
cuucagccag aacuggauag cuucaaggaa gaauuggaca aauauuucaa aaaucacacu 3480
ucacccgaug uggaccuggg ugacauuagu gguaucaaug cguccguggu caauauucaa 3540
aaagagauug acaggcucaa cgaaguggcc aagaaccuga acgaaagucu uaucgaucug 3600
caagaauugg gaaaguauga gcaguacauc aaguggccgu gguacauuug guuggguuuu 3660
aucgccgguc ugaucgccau cguuaugguu accauuaugc uuugcugcau gacgagcugu 3720
ugcuccuguc ugaagggaug cugcucuugc ggaucauguu gcaaguucga ugaagacgau 3780
agcgaaccag uucugaaggg cgucaagcug cauuacaca                        3819

<210> 49
<211> 669
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
cgcguccagc caaccgagag caucgucaga uuucccaaca uuacaaaucu gugucccuuc 60
ggcgaggugu ucaacgccac acgcuucgcu ucaguguacg cauggaaccg caagcgcaua 120
ucuaacugcg ucgcggauua uucuguccuc uacaacuccg ccucuuucuc caccuucaag 180
ugcuacggag ugucaccgac uaagcugaac gaucucugcu uuaccaacgu cuacgcggac 240
uccuucguga uaagagguga ugaagugaga caaauagccc caggucagac ugguaagauc 300
gcagauuaca acuacaaauu gccugaugau uucacugguu gcguuaucgc guggaacucu 360
aauaaccucg auucuaaggu cggugguaac uacaauuacc uguaccgcuu guuuaggaag 420
ucaaaccuga agccuuucga gagggauauu ucaaccgaaa ucuaucaagc ggguucaaca 480
ccguguaacg guguggaagg auuuaacugc uacuuccccc ugcagucuua cggauuccag 540
ccaaccaaug gcguggguua ccaaccuuau cgcguggugg uucugaguuu cgaacuguug 600
cacgcucccg ccacgguaug cggucccaag aagagcacua acuuggugaa gaauaagugc 660
gugaauuuc                                                         669

<210> 50
<211> 96
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
ggaagcggcu acaucccaga agccccuaga gacggacagg cuuacgugcg aaaagacggc 60
gagugggugc ugcugagcac auuccuggga aggagc                           96

<210> 51
<211> 99
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
cgaaugaagc agauugagga uaaaauugag gagauucuca gcaaaauuua ccacauagaa 60
aaugagaucg cucggauuaa aaaacugauc ggagaaaga                        99

<210> 52
<211> 30
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
ggcggaggag gcagcggcgg aggaggcagc                                  30

<210> 53
<211> 741
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
uuaaaacagc cuguggguug aucccaccca caggcccauu gggcgcuagc acucugguau 60
cacgguaccu uugugcgccu guuuuauacc cccuccccca acuguaacuu agaaguaaca 120
cacaccgauc aacagucagc guggcacacc agccacguuu ugaucaagca cuucuguuac 180
cccggacuga guaucaauag acugcucacg cgguugaagg agaaagcguu cguuauccgg 240
ccaacuacuu cgaaaaaccu aguaacaccg uggaaguugc agaguguuuc gcucagcacu 300
accccagugu agaucagguc gaugagucac cgcauucccc acgggcgacc guggcggugg 360
cugcguuggc ggccugccca uggggaaacc caugggacgc ucuaauacag acauggugcg 420
aagagucuau ugagcuaguu gguaguccuc cggccccuga augcggcuaa uccuaacugc 480
ggagcacaca cccucaagcc agagggcagu gugucguaac gggcaacucu gcagcggaac 540
cgacuacuuu ggguguccgu guuucauuuu auuccuauac uggcugcuua uggugacaau 600
ugagagaucg uuaccauaua gcuauuggau uggccauccg gugacuaaua gagcuauuau 660
auaucccuuu guuggguuua uaccacuuag cuugaaagag guuaaaacau uacaauucau 720
uguuaaguug aauacagcaa a                                           741

<210> 54
<211> 419
<212> PRT
<213> Homo sapiens

<400> 54
Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile His Asn
 1               5                  10                  15      
Leu Pro Tyr Gly Val Phe Ser Thr Arg Gly Asp Pro Arg Pro Arg Ile
            20                  25                  30          
Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Ile Ile Lys His
        35                  40                  45              
Leu Phe Thr Gly Pro Val Leu Ser Lys His Gln Asp Val Phe Asn Gln
    50                  55                  60                  
Pro Thr Leu Asn Ser Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu
65                  70                  75                  80  
Ala Arg Val Phe Leu Gln Asn Leu Leu Ser Val Ser Gln Ala Arg Leu
                85                  90                  95      
Arg Asp Asp Thr Glu Leu Arg Lys Cys Ala Phe Ile Ser Gln Ala Ser
            100                 105                 110         
Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr
        115                 120                 125             
Ser Ser Arg Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Asp Lys
    130                 135                 140                 
Glu Asn Ala Leu Met Pro Asn Trp Leu His Leu Pro Val Gly Tyr His
145                 150                 155                 160 
Gly Arg Ala Ser Ser Val Val Val Ser Gly Thr Pro Ile Arg Arg Pro
                165                 170                 175     
Met Gly Gln Met Lys Pro Asp Asp Ser Lys Pro Pro Val Tyr Gly Ala
            180                 185                 190         
Cys Lys Leu Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro
        195                 200                 205             
Gly Asn Arg Leu Gly Glu Pro Ile Pro Ile Ser Lys Ala His Glu His
    210                 215                 220                 
Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln
225                 230                 235                 240 
Lys Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly
                245                 250                 255     
Thr Thr Val Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe
            260                 265                 270         
Ala Val Pro Asn Pro Lys Gln Asp Pro Arg Pro Leu Pro Tyr Leu Cys
        275                 280                 285             
His Asp Glu Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Asn Leu Lys
    290                 295                 300                 
Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Lys Ser Asn Phe Lys
305                 310                 315                 320 
Tyr Met Tyr Trp Thr Met Leu Gln Gln Leu Thr His His Ser Val Asn
                325                 330                 335     
Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser
            340                 345                 350         
Gly Pro Glu Pro Glu Asn Phe Gly Ser Met Leu Glu Leu Ser Trp Lys
        355                 360                 365             
Gly Thr Lys Pro Ile Asp Leu Gly Asn Gly Gln Thr Arg Lys Phe Leu
    370                 375                 380                 
Leu Asp Gly Asp Glu Val Ile Ile Thr Gly Tyr Cys Gln Gly Asp Gly
385                 390                 395                 400 
Tyr Arg Ile Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu
                405                 410                 415     
Leu Pro Ser
            


<210> 55
<211> 354
<212> PRT
<213> Homo sapiens

<400> 55
Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn
 1               5                  10                  15      
Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln
            20                  25                  30          
Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe
        35                  40                  45              
Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys
    50                  55                  60                  
Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys
65                  70                  75                  80  
Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser
                85                  90                  95      
Thr Glu Thr Gly Leu Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr
            100                 105                 110         
Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala
        115                 120                 125             
Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys
    130                 135                 140                 
Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile
145                 150                 155                 160 
Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr
                165                 170                 175     
Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser
            180                 185                 190         
Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala
        195                 200                 205             
Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu
    210                 215                 220                 
Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn
225                 230                 235                 240 
Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly
                245                 250                 255     
Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu
            260                 265                 270         
Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met
        275                 280                 285             
Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu
    290                 295                 300                 
Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg
305                 310                 315                 320 
Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala
                325                 330                 335     
Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro
            340                 345                 350         
Lys Phe
        


<210> 56
<211> 1163
<212> PRT
<213> Homo sapiens

<400> 56
Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys
            20                  25                  30          
Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu
        35                  40                  45              
Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp
    50                  55                  60                  
Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro
65                  70                  75                  80  
Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr
                85                  90                  95      
Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly
            100                 105                 110         
Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln
        115                 120                 125             
Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys
    130                 135                 140                 
Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val
145                 150                 155                 160 
Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala
                165                 170                 175     
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly
            180                 185                 190         
Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln
        195                 200                 205             
Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser
    210                 215                 220                 
Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly
225                 230                 235                 240 
Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile
                245                 250                 255     
Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn
            260                 265                 270         
Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly
        275                 280                 285             
Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala
    290                 295                 300                 
Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg
305                 310                 315                 320 
Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly
                325                 330                 335     
Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu
            340                 345                 350         
Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg
        355                 360                 365             
Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly
    370                 375                 380                 
Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro
385                 390                 395                 400 
Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro
                405                 410                 415     
Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly
            420                 425                 430         
Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu
        435                 440                 445             
Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp
    450                 455                 460                 
Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly
465                 470                 475                 480 
Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro
                485                 490                 495     
Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro
            500                 505                 510         
Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly
        515                 520                 525             
Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly
    530                 535                 540                 
Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser
545                 550                 555                 560 
Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly
                565                 570                 575     
Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys
            580                 585                 590         
Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro
        595                 600                 605             
Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly
    610                 615                 620                 
Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu
625                 630                 635                 640 
Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro
                645                 650                 655     
Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly
            660                 665                 670         
Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu
        675                 680                 685             
Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu
    690                 695                 700                 
Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly
705                 710                 715                 720 
Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser
                725                 730                 735     
Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp
            740                 745                 750         
Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly
        755                 760                 765             
Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala
    770                 775                 780                 
Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg
785                 790                 795                 800 
Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly
                805                 810                 815     
Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu
            820                 825                 830         
Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Lys Asp
        835                 840                 845             
Gly Thr Ser Gly His Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly
    850                 855                 860                 
Asn Arg Gly Glu Arg Gly Ser Glu Gly Ser Pro Gly His Pro Gly Gln
865                 870                 875                 880 
Pro Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys Gly Gly
                885                 890                 895     
Val Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly
            900                 905                 910         
Phe Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Thr
        915                 920                 925             
Asp Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser
    930                 935                 940                 
Leu Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg
945                 950                 955                 960 
Asp Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val
                965                 970                 975     
Asp Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn
            980                 985                 990         
Met Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Leu Asn Val Pro
        995                 1000                1005            
Arg Lys His Trp Trp Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp
    1010                1015                1020                
Phe Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro
1025                1030                1035               1040 
Glu Leu Pro Glu Asp Val Leu Asp Val Gln Leu Ala Phe Leu Arg Leu
                1045                1050                1055    
Leu Ser Ser Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser
            1060                1065                1070        
Ile Ala Tyr Met Asp Gln Ala Ser Gly Asn Val Lys Lys Ala Leu Lys
        1075                1080                1085            
Leu Met Gly Ser Asn Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys
    1090                1095                1100                
Phe Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu
1105                1110                1115               1120 
Trp Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu
                1125                1130                1135    
Pro Ile Val Asp Ile Ala Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu
            1140                1145                1150        
Phe Gly Val Asp Val Gly Pro Val Cys Phe Leu
        1155                1160            


<210> 57
<211> 1038
<212> PRT
<213> Homo sapiens

<400> 57
Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp
 1               5                  10                  15      
Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg
            20                  25                  30          
Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu
        35                  40                  45              
Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser
    50                  55                  60                  
Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val
65                  70                  75                  80  
Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr
                85                  90                  95      
Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr
            100                 105                 110         
Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr
        115                 120                 125             
Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser
    130                 135                 140                 
Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val
145                 150                 155                 160 
Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr
                165                 170                 175     
Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala
            180                 185                 190         
Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu
        195                 200                 205             
Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu
    210                 215                 220                 
Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe
225                 230                 235                 240 
Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn
                245                 250                 255     
Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg
            260                 265                 270         
Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys
        275                 280                 285             
Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu
    290                 295                 300                 
Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro
305                 310                 315                 320 
Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser
                325                 330                 335     
Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe
            340                 345                 350         
Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu
        355                 360                 365             
Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala
    370                 375                 380                 
Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala
385                 390                 395                 400 
Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile
                405                 410                 415     
Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr
            420                 425                 430         
Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp
        435                 440                 445             
Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu
    450                 455                 460                 
Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile
465                 470                 475                 480 
Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys
                485                 490                 495     
Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys
            500                 505                 510         
Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu
        515                 520                 525             
Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro
    530                 535                 540                 
Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp
545                 550                 555                 560 
Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro
                565                 570                 575     
Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln
            580                 585                 590         
Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu
        595                 600                 605             
Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr
    610                 615                 620                 
Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu
625                 630                 635                 640 
His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu
                645                 650                 655     
Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu
            660                 665                 670         
Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His
        675                 680                 685             
Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser
    690                 695                 700                 
Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln
705                 710                 715                 720 
Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp
                725                 730                 735     
Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro
            740                 745                 750         
Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu
        755                 760                 765             
Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val
    770                 775                 780                 
Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His
785                 790                 795                 800 
Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val
                805                 810                 815     
Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser
            820                 825                 830         
Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln
        835                 840                 845             
Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro
    850                 855                 860                 
Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp
865                 870                 875                 880 
Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu
                885                 890                 895     
Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu
            900                 905                 910         
Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly
        915                 920                 925             
Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser
    930                 935                 940                 
Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr
945                 950                 955                 960 
Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys
                965                 970                 975     
Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser
            980                 985                 990         
Thr Glu Ser Leu Asp Cys Glu Val Asn Asn Asn Gly Ser Asn Arg Ala
        995                 1000                1005            
Val His Ser Lys Ser Ser Thr Ala Val Tyr Leu Ala Glu Gly Gly Thr
    1010                1015                1020                
Ala Thr Thr Met Val Ser Lys Asp Ile Gly Met Asn Cys Leu
1025                1030                1035            


<210> 58
<211> 1195
<212> PRT
<213> Homo sapiens

<400> 58
Met Pro Thr Ala Glu Ser Glu Ala Lys Val Lys Thr Lys Val Arg Phe
 1               5                  10                  15      
Glu Glu Leu Leu Lys Thr His Ser Asp Leu Met Arg Glu Lys Lys Lys
            20                  25                  30          
Leu Lys Lys Lys Leu Val Arg Ser Glu Glu Asn Ile Ser Pro Asp Thr
        35                  40                  45              
Ile Arg Ser Asn Leu His Tyr Met Lys Glu Thr Thr Ser Asp Asp Pro
    50                  55                  60                  
Asp Thr Ile Arg Ser Asn Leu Pro His Ile Lys Glu Thr Thr Ser Asp
65                  70                  75                  80  
Asp Val Ser Ala Ala Asn Thr Asn Asn Leu Lys Lys Ser Thr Arg Val
                85                  90                  95      
Thr Lys Asn Lys Leu Arg Asn Thr Gln Leu Ala Thr Glu Asn Pro Asn
            100                 105                 110         
Gly Asp Ala Ser Val Glu Glu Asp Lys Gln Gly Lys Pro Asn Lys Lys
        115                 120                 125             
Val Ile Lys Thr Val Pro Gln Leu Thr Thr Gln Asp Leu Lys Pro Glu
    130                 135                 140                 
Thr Pro Glu Asn Lys Val Asp Ser Thr His Gln Lys Thr His Thr Lys
145                 150                 155                 160 
Pro Gln Pro Gly Val Asp His Gln Lys Ser Glu Lys Ala Asn Glu Gly
                165                 170                 175     
Arg Glu Glu Thr Asp Leu Glu Glu Asp Glu Glu Leu Met Gln Ala Tyr
            180                 185                 190         
Gln Cys His Val Thr Glu Glu Met Ala Lys Glu Ile Lys Arg Lys Ile
        195                 200                 205             
Arg Lys Lys Leu Lys Glu Gln Leu Thr Tyr Phe Pro Ser Asp Thr Leu
    210                 215                 220                 
Phe His Asp Asp Lys Leu Ser Ser Glu Lys Arg Lys Lys Lys Lys Glu
225                 230                 235                 240 
Val Pro Val Phe Ser Lys Ala Glu Thr Ser Thr Leu Thr Ile Ser Gly
                245                 250                 255     
Asp Thr Val Glu Gly Glu Gln Lys Lys Glu Ser Ser Val Arg Ser Val
            260                 265                 270         
Ser Ser Asp Ser His Gln Asp Asp Glu Ile Ser Ser Met Glu Gln Ser
        275                 280                 285             
Thr Glu Asp Ser Met Gln Asp Asp Thr Lys Pro Lys Pro Lys Lys Thr
    290                 295                 300                 
Lys Lys Lys Thr Lys Ala Val Ala Asp Asn Asn Glu Asp Val Asp Gly
305                 310                 315                 320 
Asp Gly Val His Glu Ile Thr Ser Arg Asp Ser Pro Val Tyr Pro Lys
                325                 330                 335     
Cys Leu Leu Asp Asp Asp Leu Val Leu Gly Val Tyr Ile His Arg Thr
            340                 345                 350         
Asp Arg Leu Lys Ser Asp Phe Met Ile Ser His Pro Met Val Lys Ile
        355                 360                 365             
His Val Val Asp Glu His Thr Gly Gln Tyr Val Lys Lys Asp Asp Ser
    370                 375                 380                 
Gly Arg Pro Val Ser Ser Tyr Tyr Glu Lys Glu Asn Val Asp Tyr Ile
385                 390                 395                 400 
Leu Pro Ile Met Thr Gln Pro Tyr Asp Phe Lys Gln Leu Lys Ser Arg
                405                 410                 415     
Leu Pro Glu Trp Glu Glu Gln Ile Val Phe Asn Glu Asn Phe Pro Tyr
            420                 425                 430         
Leu Leu Arg Gly Ser Asp Glu Ser Pro Lys Val Ile Leu Phe Phe Glu
        435                 440                 445             
Ile Leu Asp Phe Leu Ser Val Asp Glu Ile Lys Asn Asn Ser Glu Val
    450                 455                 460                 
Gln Asn Gln Glu Cys Gly Phe Arg Lys Ile Ala Trp Ala Phe Leu Lys
465                 470                 475                 480 
Leu Leu Gly Ala Asn Gly Asn Ala Asn Ile Asn Ser Lys Leu Arg Leu
                485                 490                 495     
Gln Leu Tyr Tyr Pro Pro Thr Lys Pro Arg Ser Pro Leu Ser Val Val
            500                 505                 510         
Glu Ala Phe Glu Trp Trp Ser Lys Cys Pro Arg Asn His Tyr Pro Ser
        515                 520                 525             
Thr Leu Tyr Val Val Arg Gly Leu Lys Val Pro Asp Cys Ile Lys Pro
    530                 535                 540                 
Ser Tyr Arg Ser Met Met Ala Pro Gln Glu Glu Lys Gly Lys Pro Val
545                 550                 555                 560 
His Cys Glu Arg His His Glu Ser Ser Ser Val Asp Thr Glu Pro Gly
                565                 570                 575     
Leu Glu Glu Ser Lys Glu Val Ile Lys Trp Lys Arg Leu Pro Gly Gln
            580                 585                 590         
Ala Cys Arg Ile Pro Asn Lys His Leu Phe Ser Leu Asn Ala Gly Glu
        595                 600                 605             
Arg Gly Cys Phe Cys Leu Asp Phe Ser His Asn Gly Arg Ile Leu Ala
    610                 615                 620                 
Ala Ala Cys Ala Ser Arg Asp Gly Tyr Pro Ile Ile Leu Tyr Glu Ile
625                 630                 635                 640 
Pro Ser Gly Arg Phe Met Arg Glu Leu Cys Gly His Leu Asn Ile Ile
                645                 650                 655     
Tyr Asp Leu Ser Trp Ser Lys Asp Asp His Tyr Ile Leu Thr Ser Ser
            660                 665                 670         
Ser Asp Gly Thr Ala Arg Ile Trp Lys Asn Glu Ile Asn Asn Thr Asn
        675                 680                 685             
Thr Phe Arg Val Leu Pro His Pro Ser Phe Val Tyr Thr Ala Lys Phe
    690                 695                 700                 
His Pro Ala Val Arg Glu Leu Val Val Thr Gly Cys Tyr Asp Ser Met
705                 710                 715                 720 
Ile Arg Ile Trp Lys Val Glu Met Arg Glu Asp Ser Ala Ile Leu Val
                725                 730                 735     
Arg Gln Phe Asp Val His Lys Ser Phe Ile Asn Ser Leu Cys Phe Asp
            740                 745                 750         
Thr Glu Gly His His Met Tyr Ser Gly Asp Cys Thr Gly Val Ile Val
        755                 760                 765             
Val Trp Asn Thr Tyr Val Lys Ile Asn Asp Leu Glu His Ser Val His
    770                 775                 780                 
His Trp Thr Ile Asn Lys Glu Ile Lys Glu Thr Glu Phe Lys Gly Ile
785                 790                 795                 800 
Pro Ile Ser Tyr Leu Glu Ile His Pro Asn Gly Lys Arg Leu Leu Ile
                805                 810                 815     
His Thr Lys Asp Ser Thr Leu Arg Ile Met Asp Leu Arg Ile Leu Val
            820                 825                 830         
Ala Arg Lys Phe Val Gly Ala Ala Asn Tyr Arg Glu Lys Ile His Ser
        835                 840                 845             
Thr Leu Thr Pro Cys Gly Thr Phe Leu Phe Ala Gly Ser Glu Asp Gly
    850                 855                 860                 
Ile Val Tyr Val Trp Asn Pro Glu Thr Gly Glu Gln Val Ala Met Tyr
865                 870                 875                 880 
Ser Asp Leu Pro Phe Lys Ser Pro Ile Arg Asp Ile Ser Tyr His Pro
                885                 890                 895     
Phe Glu Asn Met Val Ala Phe Cys Ala Phe Gly Gln Asn Glu Pro Ile
            900                 905                 910         
Leu Leu Tyr Ile Tyr Asp Phe His Val Ala Gln Gln Glu Ala Glu Met
        915                 920                 925             
Phe Lys Arg Tyr Asn Gly Thr Phe Pro Leu Pro Gly Ile His Gln Ser
    930                 935                 940                 
Gln Asp Ala Leu Cys Thr Cys Pro Lys Leu Pro His Gln Gly Ser Phe
945                 950                 955                 960 
Gln Ile Asp Glu Phe Val His Thr Glu Ser Ser Ser Thr Lys Met Gln
                965                 970                 975     
Leu Val Lys Gln Arg Leu Glu Thr Val Thr Glu Val Ile Arg Ser Cys
            980                 985                 990         
Ala Ala Lys Val Asn Lys Asn Leu Ser Phe Thr Ser Pro Pro Ala Val
        995                 1000                1005            
Ser Ser Gln Gln Ser Lys Leu Lys Gln Ser Asn Met Leu Thr Ala Gln
    1010                1015                1020                
Glu Ile Leu His Gln Phe Gly Phe Thr Gln Thr Gly Ile Ile Ser Ile
1025                1030                1035               1040 
Glu Arg Lys Pro Cys Asn His Gln Val Asp Thr Ala Pro Thr Val Val
                1045                1050                1055    
Ala Leu Tyr Asp Tyr Thr Ala Asn Arg Ser Asp Glu Leu Thr Ile His
            1060                1065                1070        
Arg Gly Asp Ile Ile Arg Val Phe Phe Lys Asp Asn Glu Asp Trp Trp
        1075                1080                1085            
Tyr Gly Ser Ile Gly Lys Gly Gln Glu Gly Tyr Phe Pro Ala Asn His
    1090                1095                1100                
Val Ala Ser Glu Thr Leu Tyr Gln Glu Leu Pro Pro Glu Ile Lys Glu
1105                1110                1115               1120 
Arg Ser Pro Pro Leu Ser Pro Glu Glu Lys Thr Lys Ile Glu Lys Ser
                1125                1130                1135    
Pro Ala Pro Gln Lys Gln Ser Ile Asn Lys Asn Lys Ser Gln Asp Phe
            1140                1145                1150        
Arg Leu Gly Ser Glu Ser Met Thr His Ser Glu Met Arg Lys Glu Gln
        1155                1160                1165            
Ser His Glu Asp Gln Gly His Ile Met Asp Thr Arg Met Arg Lys Asn
    1170                1175                1180                
Lys Gln Ala Gly Arg Lys Val Thr Leu Ile Glu
1185                1190                1195


<210> 59
<211> 558
<212> PRT
<213> Homo sapiens

<400> 59
Met Ala Gln Asp Ser Val Asp Leu Ser Cys Asp Tyr Gln Phe Trp Met
 1               5                  10                  15      
Gln Lys Leu Ser Val Trp Asp Gln Ala Ser Thr Leu Glu Thr Gln Gln
            20                  25                  30          
Asp Thr Cys Leu His Val Ala Gln Phe Gln Glu Phe Leu Arg Lys Met
        35                  40                  45              
Tyr Glu Ala Leu Lys Glu Met Asp Ser Asn Thr Val Ile Glu Arg Phe
    50                  55                  60                  
Pro Thr Ile Gly Gln Leu Leu Ala Lys Ala Cys Trp Asn Pro Phe Ile
65                  70                  75                  80  
Leu Ala Tyr Asp Glu Ser Gln Lys Ile Leu Ile Trp Cys Leu Cys Cys
                85                  90                  95      
Leu Ile Asn Lys Glu Pro Gln Asn Ser Gly Gln Ser Lys Leu Asn Ser
            100                 105                 110         
Trp Ile Gln Gly Val Leu Ser His Ile Leu Ser Ala Leu Arg Phe Asp
        115                 120                 125             
Lys Glu Val Ala Leu Phe Thr Gln Gly Leu Gly Tyr Ala Pro Ile Asp
    130                 135                 140                 
Tyr Tyr Pro Gly Leu Leu Lys Asn Met Val Leu Ser Leu Ala Ser Glu
145                 150                 155                 160 
Leu Arg Glu Asn His Leu Asn Gly Phe Asn Thr Gln Arg Arg Met Ala
                165                 170                 175     
Pro Glu Arg Val Ala Ser Leu Ser Arg Val Cys Val Pro Leu Ile Thr
            180                 185                 190         
Leu Thr Asp Val Asp Pro Leu Val Glu Ala Leu Leu Ile Cys His Gly
        195                 200                 205             
Arg Glu Pro Gln Glu Ile Leu Gln Pro Glu Phe Phe Glu Ala Val Asn
    210                 215                 220                 
Glu Ala Ile Leu Leu Lys Lys Ile Ser Leu Pro Met Ser Ala Val Val
225                 230                 235                 240 
Cys Leu Trp Leu Arg His Leu Pro Ser Leu Glu Lys Ala Met Leu His
                245                 250                 255     
Leu Phe Glu Lys Leu Ile Ser Ser Glu Arg Asn Cys Leu Arg Arg Ile
            260                 265                 270         
Glu Cys Phe Ile Lys Asp Ser Ser Leu Pro Gln Ala Ala Cys His Pro
        275                 280                 285             
Ala Ile Phe Arg Val Val Asp Glu Met Phe Arg Cys Ala Leu Leu Glu
    290                 295                 300                 
Thr Asp Gly Ala Leu Glu Ile Ile Ala Thr Ile Gln Val Phe Thr Gln
305                 310                 315                 320 
Cys Phe Val Glu Ala Leu Glu Lys Ala Ser Lys Gln Leu Arg Phe Ala
                325                 330                 335     
Leu Lys Thr Tyr Phe Pro Tyr Thr Ser Pro Ser Leu Ala Met Val Leu
            340                 345                 350         
Leu Gln Asp Pro Gln Asp Ile Pro Arg Gly His Trp Leu Gln Thr Leu
        355                 360                 365             
Lys His Ile Ser Glu Leu Leu Arg Glu Ala Val Glu Asp Gln Thr His
    370                 375                 380                 
Gly Ser Cys Gly Gly Pro Phe Glu Ser Trp Phe Leu Phe Ile His Phe
385                 390                 395                 400 
Gly Gly Trp Ala Glu Met Val Ala Glu Gln Leu Leu Met Ser Ala Ala
                405                 410                 415     
Glu Pro Pro Thr Ala Leu Leu Trp Leu Leu Ala Phe Tyr Tyr Gly Pro
            420                 425                 430         
Arg Asp Gly Arg Gln Gln Arg Ala Gln Thr Met Val Gln Val Lys Ala
        435                 440                 445             
Val Leu Gly His Leu Leu Ala Met Ser Arg Ser Ser Ser Leu Ser Ala
    450                 455                 460                 
Gln Asp Leu Gln Thr Val Ala Gly Gln Gly Thr Asp Thr Asp Leu Arg
465                 470                 475                 480 
Ala Pro Ala Gln Gln Leu Ile Arg His Leu Leu Leu Asn Phe Leu Leu
                485                 490                 495     
Trp Ala Pro Gly Gly His Thr Ile Ala Trp Asp Val Ile Thr Leu Met
            500                 505                 510         
Ala His Thr Ala Glu Ile Thr His Glu Ile Ile Gly Phe Leu Asp Gln
        515                 520                 525             
Thr Leu Tyr Arg Trp Asn Arg Leu Gly Ile Glu Ser Pro Arg Ser Glu
    530                 535                 540                 
Lys Leu Ala Arg Glu Leu Leu Lys Glu Leu Arg Thr Gln Val
545                 550                 555             


<210> 60
<211> 1274
<212> PRT
<213> Homo sapiens

<400> 60
Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro
 1               5                  10                  15      
Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu
            20                  25                  30          
Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp
        35                  40                  45              
Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His
    50                  55                  60                  
Thr Leu Ala Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala
65                  70                  75                  80  
Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu
                85                  90                  95      
Ala Glu Glu Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu
            100                 105                 110         
Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly
        115                 120                 125             
Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly
    130                 135                 140                 
Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg
145                 150                 155                 160 
Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala
                165                 170                 175     
Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe
            180                 185                 190         
Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln
        195                 200                 205             
Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu
    210                 215                 220                 
His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu
225                 230                 235                 240 
Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val
                245                 250                 255     
His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg
            260                 265                 270         
Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu
        275                 280                 285             
Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser
    290                 295                 300                 
Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp
305                 310                 315                 320 
Val Trp Glu Thr Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile
                325                 330                 335     
Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu
            340                 345                 350         
Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys
        355                 360                 365             
Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr
    370                 375                 380                 
Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asp Gly
385                 390                 395                 400 
Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly
                405                 410                 415     
Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala
            420                 425                 430         
Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe
        435                 440                 445             
Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu
    450                 455                 460                 
Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu
465                 470                 475                 480 
Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu
                485                 490                 495     
Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu
            500                 505                 510         
Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys
        515                 520                 525             
Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys
    530                 535                 540                 
Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp
545                 550                 555                 560 
Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val
                565                 570                 575     
Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val
            580                 585                 590         
Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro
        595                 600                 605             
Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn
    610                 615                 620                 
Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro
625                 630                 635                 640 
Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro
                645                 650                 655     
Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro
            660                 665                 670         
Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr
        675                 680                 685             
Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp
    690                 695                 700                 
Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu
705                 710                 715                 720 
Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe
                725                 730                 735     
Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr
            740                 745                 750         
Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val
        755                 760                 765             
Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly
    770                 775                 780                 
Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly
785                 790                 795                 800 
Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr
                805                 810                 815     
Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu
            820                 825                 830         
Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala
        835                 840                 845             
Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe
    850                 855                 860                 
Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp
865                 870                 875                 880 
Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val
                885                 890                 895     
Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly
            900                 905                 910         
Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser
        915                 920                 925             
Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Ser Arg Val
    930                 935                 940                 
Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu
945                 950                 955                 960 
Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro
                965                 970                 975     
Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn
            980                 985                 990         
Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr
        995                 1000                1005            
Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser
    1010                1015                1020                
Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser
1025                1030                1035               1040 
Gly Thr Tyr Gln Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala
                1045                1050                1055    
Thr Leu Val Leu Gln Val Val Asp Lys Pro Ser Pro Pro Gln Asp Leu
            1060                1065                1070        
Arg Val Thr Asp Ala Trp Gly Leu Asn Val Ala Leu Glu Trp Lys Pro
        1075                1080                1085            
Pro Gln Asp Val Gly Asn Thr Glu Leu Trp Gly Tyr Thr Val Gln Lys
    1090                1095                1100                
Ala Asp Lys Lys Thr Met Glu Trp Phe Thr Val Leu Glu His Tyr Arg
1105                1110                1115               1120 
Arg Thr His Cys Val Val Pro Glu Leu Ile Ile Gly Asn Gly Tyr Tyr
                1125                1130                1135    
Phe Arg Val Phe Ser Gln Asn Met Val Gly Phe Ser Asp Arg Ala Ala
            1140                1145                1150        
Thr Thr Lys Glu Pro Val Phe Ile Pro Arg Pro Gly Ile Thr Tyr Glu
        1155                1160                1165            
Pro Pro Asn Tyr Lys Ala Leu Asp Phe Ser Glu Ala Pro Ser Phe Thr
    1170                1175                1180                
Gln Pro Leu Val Asn Arg Ser Val Ile Ala Gly Tyr Thr Ala Met Leu
1185                1190                1195               1200 
Cys Cys Ala Val Arg Gly Ser Pro Lys Pro Lys Ile Ser Trp Phe Lys
                1205                1210                1215    
Asn Gly Leu Asp Leu Gly Glu Asp Ala Arg Phe Arg Met Phe Ser Lys
            1220                1225                1230        
Gln Gly Val Leu Thr Leu Glu Ile Arg Lys Pro Cys Pro Phe Asp Gly
        1235                1240                1245            
Gly Ile Tyr Val Cys Arg Ala Thr Asn Leu Gln Gly Glu Ala Arg Cys
    1250                1255                1260                
Glu Cys Arg Leu Glu Val Arg Val Pro Gln
1265                1270                


<210> 61
<211> 369
<212> PRT
<213> Homo sapiens

<400> 61
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
 1               5                  10                  15      
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30          
Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45              
Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  60                  
Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80  
Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95      
Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110         
Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125             
Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140                 
Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160 
Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175     
Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190         
Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205             
Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220                 
Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp
225                 230                 235                 240 
Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe
                245                 250                 255     
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270         
Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285             
Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300                 
Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320 
Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335     
Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350         
Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365             
Thr
    


<210> 62
<211> 1272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn
 1               5                  10                  15      
Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr
            20                  25                  30          
Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His
        35                  40                  45              
Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe
    50                  55                  60                  
His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn
65                  70                  75                  80  
Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys
                85                  90                  95      
Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys
            100                 105                 110         
Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys
        115                 120                 125             
Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr
    130                 135                 140                 
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser
145                 150                 155                 160 
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met
                165                 170                 175     
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val
            180                 185                 190         
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro
        195                 200                 205             
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro
    210                 215                 220                 
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu
225                 230                 235                 240 
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly
                245                 250                 255     
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg
            260                 265                 270         
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val
        275                 280                 285             
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser
    290                 295                 300                 
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln
305                 310                 315                 320 
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro
                325                 330                 335     
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp
            340                 345                 350         
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr
        355                 360                 365             
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr
    370                 375                 380                 
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
385                 390                 395                 400 
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
                405                 410                 415     
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val
            420                 425                 430         
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr
        435                 440                 445             
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu
    450                 455                 460                 
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
465                 470                 475                 480 
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe
                485                 490                 495     
Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu
            500                 505                 510         
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys
        515                 520                 525             
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly
    530                 535                 540                 
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro
545                 550                 555                 560 
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg
                565                 570                 575     
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly
            580                 585                 590         
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala
        595                 600                 605             
Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His
    610                 615                 620                 
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn
625                 630                 635                 640 
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn
                645                 650                 655     
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser
            660                 665                 670         
Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser
        675                 680                 685             
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val
    690                 695                 700                 
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser
705                 710                 715                 720 
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp
                725                 730                 735     
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu
            740                 745                 750         
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly
        755                 760                 765             
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val
    770                 775                 780                 
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn
785                 790                 795                 800 
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe
                805                 810                 815     
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe
            820                 825                 830         
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu
        835                 840                 845             
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu
    850                 855                 860                 
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr
865                 870                 875                 880 
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro
                885                 890                 895     
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln
            900                 905                 910         
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser
        915                 920                 925             
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu
    930                 935                 940                 
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr
945                 950                 955                 960 
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu
                965                 970                 975     
Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile
            980                 985                 990         
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr
        995                 1000                1005            
Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala
    1010                1015                1020                
Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp
1025                1030                1035               1040 
Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro
                1045                1050                1055    
His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu Lys
            1060                1065                1070        
Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe
        1075                1080                1085            
Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val Thr
    1090                1095                1100                
Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe
1105                1110                1115               1120 
Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val
                1125                1130                1135    
Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp
            1140                1145                1150        
Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile
        1155                1160                1165            
Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg
    1170                1175                1180                
Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln
1185                1190                1195               1200 
Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp
                1205                1210                1215    
Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met
            1220                1225                1230        
Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser
        1235                1240                1245            
Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu
    1250                1255                1260                
Lys Gly Val Lys Leu His Tyr Thr
1265                1270        


<210> 63
<211> 223
<212> PRT
<213> SARS-CoV-2

<400> 63
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn
 1               5                  10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val
            20                  25                  30          
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser
        35                  40                  45              
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val
    50                  55                  60                  
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp
65                  70                  75                  80  
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln
                85                  90                  95      
Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr
            100                 105                 110         
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly
        115                 120                 125             
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr
145                 150                 155                 160 
Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser
                165                 170                 175     
Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val
            180                 185                 190         
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly
        195                 200                 205             
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe
    210                 215                 220             


<210> 64
<211> 669
<212> DNA
<213> SARS-CoV-2

<400> 64
cgcgtccagc caaccgagag catcgtcaga tttcccaaca ttacaaatct gtgtcccttc 60
ggcgaggtgt tcaacgccac acgcttcgct tcagtgtacg catggaaccg caagcgcata 120
tctaactgcg tcgcggatta ttctgtcctc tacaactccg cctctttctc caccttcaag 180
tgctacggag tgtcaccgac taagctgaac gatctctgct ttaccaacgt ctacgcggac 240
tccttcgtga taagaggtga tgaagtgaga caaatagccc caggtcagac tggtaacatc 300
gcagattaca actacaaatt gcctgatgat ttcactggtt gcgttatcgc gtggaactct 360
aataacctcg attctaaggt cggtggtaac tacaattacc tgtaccgctt gtttaggaag 420
tcaaacctga agcctttcga gagggatatt tcaaccgaaa tctatcaagc gggttcaaca 480
ccgtgtaacg gtgtgaaagg atttaactgc tacttccccc tgcagtctta cggattccag 540
ccaacctatg gcgtgggtta ccaaccttat cgcgtggtgg ttctgagttt cgaactgttg 600
cacgctcccg ccacggtatg cggtcccaag aagagcacta acttggtgaa gaataagtgc 660
gtgaatttc                                                         669

<210> 65
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 65
Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile
 1               5                  10                  15      
Val Arg
        


<210> 66
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 66
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn
 1               5                  10                  15      
Leu
    


<210> 67
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 67
Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val
 1               5                  10                  15      
Phe
    


<210> 68
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 68
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala
 1               5                  10                  15      
Ser Val
        


<210> 69
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 69
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys
 1               5                  10                  15      
Arg Ile
        


<210> 70
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 70
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp
 1               5                  10                  15      
Tyr
    


<210> 71
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 71
Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser
 1               5                  10                  15      
Ala
    


<210> 72
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 72
Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys
 1               5                  10                  15      
Cys Tyr
        


<210> 73
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 73
Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys
 1               5                  10                  15      
Leu
    


<210> 74
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 74
Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr
 1               5                  10                  15      
Asn Val
        


<210> 75
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 75
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
 1               5                  10                  15      
Ile Arg
        


<210> 76
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 76
Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln
 1               5                  10                  15      
Ile Ala
        


<210> 77
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 77
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
 1               5                  10                  15      
Ile Ala
        


<210> 78
<211> 16
<212> PRT
<213> SARS-CoV-2

<400> 78
Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu
 1               5                  10                  15      


<210> 79
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 79
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly
 1               5                  10                  15      
Cys Val
        


<210> 80
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 80
Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn
 1               5                  10                  15      
Asn Leu
        


<210> 81
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 81
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly
 1               5                  10                  15      
Asn Tyr
        


<210> 82
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 82
Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu
 1               5                  10                  15      
Phe Arg
        


<210> 83
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 83
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro
 1               5                  10                  15      
Phe
    


<210> 84
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 84
Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr
 1               5                  10                  15      
Glu Ile
        


<210> 85
<211> 13
<212> PRT
<213> SARS-CoV-2

<400> 85
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala
 1               5                  10              


<210> 86
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 86
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
 1               5                  10                  15      
Gly Val
        


<210> 87
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 87
Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys
 1               5                  10                  15      
Tyr Phe
        


<210> 88
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 88
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly
 1               5                  10                  15      
Phe
    


<210> 89
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 89
Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val
 1               5                  10                  15      
Gly Tyr
        


<210> 90
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 90
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val
 1               5                  10                  15      
Val Leu
        


<210> 91
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 91
Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His
 1               5                  10                  15      
Ala
    


<210> 92
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 92
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly
 1               5                  10                  15      
Pro Lys
        


<210> 93
<211> 17
<212> PRT
<213> SARS-CoV-2

<400> 93
His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val
 1               5                  10                  15      
Lys
    


<210> 94
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 94
Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe
 1               5                  10                  15      
Asn Phe
        


<210> 95
<211> 18
<212> PRT
<213> SARS-CoV-2

<400> 95
Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr
 1               5                  10                  15      
Gly Val
        
