               SEQUENCE LISTING

<110> Pharmact Holding AG

<120> In vitro diagnostic test kit for detecting the presence or absence of an infectious analyte particle and detection method

<130> P4720WO

<150> PCT/EPPCZ/2020/073480
<151> 2020-08-21

<160> 30

<170> BiSSAP 1.3.6

<210> 1
<211> 805
<212> PRT
<213> Homo sapiens


<220> 
<223> ACE2 Homo sapiens

<400> 1
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      
Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          
Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              
Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  
Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  
Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      
Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         
Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             
Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 
Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 
Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     
Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         
Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             
Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 
Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 
His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     
Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         
Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             
Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 
Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 
Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     
Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         
Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             
Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 
Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 
His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     
His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         
Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             
Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 
Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 
Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     
Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         
Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             
Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 
Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 
Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     
Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         
Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             
Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 
Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 
Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     
Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         
Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             
Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 
Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 
Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     
Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         
Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             
Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 
Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 
Val Gln Thr Ser Phe 
                805 

<210> 2
<211> 31
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACE2-like

<400> 2
Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu 
1               5                   10                  15      
Asp Leu Phe Tyr Gln Ser Ser Gly Leu Gly Lys Gly Asp Phe Arg 
            20                  25                  30      

<210> 3
<211> 31
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACE2-like

<400> 3
Glu Gln Glu Glu Arg Ile Gln Gln Asp Lys Arg Lys Asn Glu Gln Glu 
1               5                   10                  15      
Asp Lys Arg Tyr Gln Arg Tyr Gly Arg Gly Lys Gly His Gln Pro 
            20                  25                  30      

<210> 4
<211> 85
<212> PRT
<213> Artificial Sequence


<220> 
<223> ACE2-like

<400> 4
Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
1               5                   10                  15      
Glu Ala Arg Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr 
            20                  25                  30          
Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly 
        35                  40                  45              
Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met 
    50                  55                  60                  
Tyr Pro Leu Gln Glu Ile Gln Asn Gln Thr Val Lys Gln Gln Leu Gln 
65                  70                  75                  80  
Ala Leu Gln Gln Asn 
                85  

<210> 5
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 5
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Gln Thr His Tyr Val Ser Tyr Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         
Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Lys 
        115                 120                 125             



<210> 6
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr Glu Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         
Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Lys 
        115                 120                 125             



<210> 7
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 7
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Thr 
            20                  25                  30          
Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Leu Ile Thr Val Asn Gly His Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala Ala Trp Gly Tyr Ala Trp Pro Leu His Gln Asp Asp Tyr 
            100                 105                 110         
Trp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 

<210> 8
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 8
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Lys Asn Phe 
            20                  25                  30          
Glu Met Glu Trp Tyr Arg Lys Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Gln Ser Gly Gly Val Glu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Phe Val Tyr Val Gly Arg Ser Tyr Ile Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser 
        

<210> 9
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 9
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Phe Ser Gly 
            20                  25                  30          
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Leu Ser Asn Gly Asp Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Arg Val His Val Gly Ala His Tyr Phe Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser 
        

<210> 10
<211> 36
<212> PRT
<213> Severe acute respiratory dyndrome coronavirus 2


<220> 
<223> SARS-CoV-2 HR2 domain fragment

<400> 10
Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
1               5                   10                  15      
Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp 
            20                  25                  30          
Leu Gln Glu Leu 
        35      

<210> 11
<211> 34
<212> PRT
<213> Artificial Sequence


<220> 
<223> HR2-like

<400> 11
Ser Leu Asp Gln Ile Asn Val Thr Phe Leu Asp Leu Glu Tyr Glu Met 
1               5                   10                  15      
Lys Leu Glu Glu Ala Ile Lys Leu Glu Glu Ser Tyr Ile Asp Leu Lys 
            20                  25                  30          
Glu Leu 
        

<210> 12
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 12
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Ser Glu 
            20                  25                  30          
Asn Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Tyr Ser Thr Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Val Gln Val Gly Tyr Trp Tyr Glu Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser 
        

<210> 13
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 13
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Pro Val Asp Thr Tyr 
            20                  25                  30          
His Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Val Ser Trp Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Val Lys Asp Ile Gly Ala Gln Glu Val His Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 

<210> 14
<211> 114
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 14
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Tyr Ser Trp 
            20                  25                  30          
Asn Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Glu Ser His Gly Asp Ser Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Tyr Val Trp Val Gly His Thr Tyr Tyr Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser 
        

<210> 15
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 15
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Val Trp 
            20                  25                  30          
Arg Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Glu Ser Tyr Gly His Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Val Lys Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 

<210> 16
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Val Trp 
            20                  25                  30          
Arg Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Ala Ile Glu Ser Tyr Gly His Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Val Tyr Asp Asp Gly Gln Leu Ala Tyr His Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 

<210> 17
<211> 1662
<212> PRT
<213> Homo sapiens


<220> 
<223> DMBT1 Homo sapiens

<400> 17
Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      
Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Thr Ser 
            20                  25                  30          
Leu Ile Pro Ser Glu Val Pro Leu Asp Thr Thr Val Ala Glu Gly Ser 
        35                  40                  45              
Pro Phe Pro Ser Glu Leu Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  
Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  
Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      
Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         
Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             
Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 
Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 
Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     
Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         
His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             
Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 
Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 
Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     
Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         
Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             
Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 
Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 
His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     
Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         
Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             
Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 
Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 
Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     
Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         
Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             
Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 
Ala His Ser Trp Ser Thr Pro Arg Pro Gly Glu Arg Pro Arg Pro Asp 
465                 470                 475                 480 
Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser 
                485                 490                 495     
Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
            500                 505                 510         
Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
        515                 520                 525             
Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
    530                 535                 540                 
Trp Ala Met Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
545                 550                 555                 560 
Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu 
                565                 570                 575     
Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser 
            580                 585                 590         
Glu Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro 
        595                 600                 605             
Ser Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu 
    610                 615                 620                 
Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly 
625                 630                 635                 640 
Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp 
                645                 650                 655     
Tyr Trp Asp Ile Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys 
            660                 665                 670         
Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser 
        675                 680                 685             
Gly Pro Ile Val Leu Asp Asp Val His Cys Ser Gly His Glu Ser Tyr 
    690                 695                 700                 
Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His 
705                 710                 715                 720 
His Glu Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr 
                725                 730                 735     
Pro Ser Pro Asp Thr Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser 
            740                 745                 750         
Glu Ser Thr Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg 
        755                 760                 765             
Gly Arg Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp 
    770                 775                 780                 
Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
785                 790                 795                 800 
Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly 
                805                 810                 815     
Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
            820                 825                 830         
Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
        835                 840                 845             
His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser 
    850                 855                 860                 
Thr Pro Arg Pro Asp Thr Trp Leu Thr Thr Asn Leu Pro Ala Leu Thr 
865                 870                 875                 880 
Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp 
                885                 890                 895     
Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr 
            900                 905                 910         
Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg 
        915                 920                 925             
Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Arg Phe 
    930                 935                 940                 
Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly 
945                 950                 955                 960 
Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Lys Gly Trp Leu Thr His 
                965                 970                 975     
Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Thr Gln 
            980                 985                 990         
Ile Asn Ser Thr Thr Thr Asp Trp Trp His Pro Thr Thr Thr Thr Thr 
        995                 1000                1005            
Ala Arg Pro Ser Ser Asn Cys Gly Gly Phe Leu Phe Tyr Ala Ser Gly 
    1010                1015                1020                
Thr Phe Ser Ser Pro Ser Tyr Pro Ala Tyr Tyr Pro Asn Asn Ala Lys 
1025                1030                1035                1040
Cys Val Trp Glu Ile Glu Val Asn Ser Gly Tyr Arg Ile Asn Leu Gly 
                1045                1050                1055    
Phe Ser Asn Leu Lys Leu Glu Ala His His Asn Cys Ser Phe Asp Tyr 
            1060                1065                1070        
Val Glu Ile Phe Asp Gly Ser Leu Asn Ser Ser Leu Leu Leu Gly Lys 
        1075                1080                1085            
Ile Cys Asn Asp Thr Arg Gln Ile Phe Thr Ser Ser Tyr Asn Arg Met 
    1090                1095                1100                
Thr Ile His Phe Arg Ser Asp Ile Ser Phe Gln Asn Thr Gly Phe Leu 
1105                1110                1115                1120
Ala Trp Tyr Asn Ser Phe Pro Ser Asp Ala Thr Leu Arg Leu Val Asn 
                1125                1130                1135    
Leu Asn Ser Ser Tyr Gly Leu Cys Ala Gly Arg Val Glu Ile Tyr His 
            1140                1145                1150        
Gly Gly Thr Trp Gly Thr Val Cys Asp Asp Ser Trp Thr Ile Gln Glu 
        1155                1160                1165            
Ala Glu Val Val Cys Arg Gln Leu Gly Cys Gly Arg Ala Val Ser Ala 
    1170                1175                1180                
Leu Gly Asn Ala Tyr Phe Gly Ser Gly Ser Gly Pro Ile Thr Leu Asp 
1185                1190                1195                1200
Asp Val Glu Cys Ser Gly Thr Glu Ser Thr Leu Trp Gln Cys Arg Asn 
                1205                1210                1215    
Arg Gly Trp Phe Ser His Asn Cys Asn His Arg Glu Asp Ala Gly Val 
            1220                1225                1230        
Ile Cys Ser Gly Asn His Leu Ser Thr Pro Ala Pro Phe Leu Asn Ile 
        1235                1240                1245            
Thr Arg Pro Asn Thr Asp Tyr Ser Cys Gly Gly Phe Leu Ser Gln Pro 
    1250                1255                1260                
Ser Gly Asp Phe Ser Ser Pro Phe Tyr Pro Gly Asn Tyr Pro Asn Asn 
1265                1270                1275                1280
Ala Lys Cys Val Trp Asp Ile Glu Val Gln Asn Asn Tyr Arg Val Thr 
                1285                1290                1295    
Val Ile Phe Arg Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr 
            1300                1305                1310        
Ile Glu Val Phe Asp Gly Pro Tyr Arg Ser Ser Pro Leu Ile Ala Arg 
        1315                1320                1325            
Val Cys Asp Gly Ala Arg Gly Ser Phe Thr Ser Ser Ser Asn Phe Met 
    1330                1335                1340                
Ser Ile Arg Phe Ile Ser Asp His Ser Ile Thr Arg Arg Gly Phe Arg 
1345                1350                1355                1360
Ala Glu Tyr Tyr Ser Ser Pro Ser Asn Asp Ser Thr Asn Leu Leu Cys 
                1365                1370                1375    
Leu Pro Asn His Met Gln Ala Ser Val Ser Arg Ser Tyr Leu Gln Ser 
            1380                1385                1390        
Leu Gly Phe Ser Ala Ser Asp Leu Val Ile Ser Thr Trp Asn Gly Tyr 
        1395                1400                1405            
Tyr Glu Cys Arg Pro Gln Ile Thr Pro Asn Leu Val Ile Phe Thr Ile 
    1410                1415                1420                
Pro Tyr Ser Gly Cys Gly Thr Phe Lys Gln Ala Asp Asn Asp Thr Ile 
1425                1430                1435                1440
Asp Tyr Ser Asn Phe Leu Thr Ala Ala Val Ser Gly Gly Ile Ile Lys 
                1445                1450                1455    
Arg Arg Thr Asp Leu Arg Ile His Val Ser Cys Arg Met Leu Gln Asn 
            1460                1465                1470        
Thr Trp Val Asp Thr Met Tyr Ile Ala Asn Asp Thr Ile His Val Ala 
        1475                1480                1485            
Asn Asn Thr Ile Gln Val Glu Glu Val Gln Tyr Gly Asn Phe Asp Val 
    1490                1495                1500                
Asn Ile Ser Phe Tyr Thr Ser Ser Ser Phe Leu Tyr Pro Val Thr Ser 
1505                1510                1515                1520
Arg Pro Tyr Tyr Val Asp Leu Asn Gln Asp Leu Tyr Val Gln Ala Glu 
                1525                1530                1535    
Ile Leu His Ser Asp Ala Val Leu Thr Leu Phe Val Asp Thr Cys Val 
            1540                1545                1550        
Ala Ser Pro Tyr Ser Asn Asp Phe Thr Ser Leu Thr Tyr Asp Leu Ile 
        1555                1560                1565            
Arg Ser Gly Cys Val Arg Asp Asp Thr Tyr Gly Pro Tyr Ser Ser Pro 
    1570                1575                1580                
Ser Leu Arg Ile Ala Arg Phe Arg Phe Arg Ala Phe His Phe Leu Asn 
1585                1590                1595                1600
Arg Phe Pro Ser Val Tyr Leu Arg Cys Lys Met Val Val Cys Arg Ala 
                1605                1610                1615    
Tyr Asp Pro Ser Ser Arg Cys Tyr Arg Gly Cys Val Ser Arg Ser Lys 
            1620                1625                1630        
Arg Asp Val Gly Ser Tyr Gln Glu Lys Val Asp Val Val Leu Gly Pro 
        1635                1640                1645            
Ile Gln Leu Gln Thr Pro Pro Arg Arg Glu Glu Glu Pro Arg 
    1650                1655                1660        

<210> 18
<211> 518
<212> PRT
<213> Homo sapiens


<220> 
<223> NR1F3 Homo sapiens

<400> 18
Met Asp Arg Ala Pro Gln Arg Gln His Arg Ala Ser Arg Glu Leu Leu 
1               5                   10                  15      
Ala Ala Lys Lys Thr His Thr Ser Gln Ile Glu Val Ile Pro Cys Lys 
            20                  25                  30          
Ile Cys Gly Asp Lys Ser Ser Gly Ile His Tyr Gly Val Ile Thr Cys 
        35                  40                  45              
Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Gln Arg Cys Asn Ala Ala 
    50                  55                  60                  
Tyr Ser Cys Thr Arg Gln Gln Asn Cys Pro Ile Asp Arg Thr Ser Arg 
65                  70                  75                  80  
Asn Arg Cys Gln His Cys Arg Leu Gln Lys Cys Leu Ala Leu Gly Met 
                85                  90                  95      
Ser Arg Asp Ala Val Lys Phe Gly Arg Met Ser Lys Lys Gln Arg Asp 
            100                 105                 110         
Ser Leu His Ala Glu Val Gln Lys Gln Leu Gln Gln Arg Gln Gln Gln 
        115                 120                 125             
Gln Gln Glu Pro Val Val Lys Thr Pro Pro Ala Gly Ala Gln Gly Ala 
    130                 135                 140                 
Asp Thr Leu Thr Tyr Thr Leu Gly Leu Pro Asp Gly Gln Leu Pro Leu 
145                 150                 155                 160 
Gly Ser Ser Pro Asp Leu Pro Glu Ala Ser Ala Cys Pro Pro Gly Leu 
                165                 170                 175     
Leu Lys Ala Ser Gly Ser Gly Pro Ser Tyr Ser Asn Asn Leu Ala Lys 
            180                 185                 190         
Ala Gly Leu Asn Gly Ala Ser Cys His Leu Glu Tyr Ser Pro Glu Arg 
        195                 200                 205             
Gly Lys Ala Glu Gly Arg Glu Ser Phe Tyr Ser Thr Gly Ser Gln Leu 
    210                 215                 220                 
Thr Pro Asp Arg Cys Gly Leu Arg Phe Glu Glu His Arg His Pro Gly 
225                 230                 235                 240 
Leu Gly Glu Leu Gly Gln Gly Pro Asp Ser Tyr Gly Ser Pro Ser Phe 
                245                 250                 255     
Arg Ser Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His 
            260                 265                 270         
Leu Val Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg 
        275                 280                 285             
Leu Glu Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu 
    290                 295                 300                 
Val Thr Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys 
305                 310                 315                 320 
Ala His His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys 
                325                 330                 335     
Arg Leu Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala 
        355                 360                 365             
Tyr Asn Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly 
    370                 375                 380                 
Met Glu Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile 
385                 390                 395                 400 
Phe Asp Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu 
                405                 410                 415     
Ile Ala Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly 
            420                 425                 430         
Leu Gln Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu 
        435                 440                 445             
Ala Phe His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala 
    450                 455                 460                 
Lys Leu Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val 
465                 470                 475                 480 
Glu Arg Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala 
                485                 490                 495     
Ala Phe Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser 
            500                 505                 510         
Pro Val Gly Leu Ser Lys 
        515             

<210> 19
<211> 94
<212> PRT
<213> Homo sapiens


<220> 
<223> Neutrophil defensin 1 Homo sapiens

<400> 19
Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      
Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          
Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              
Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  
Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  

<210> 20
<211> 94
<212> PRT
<213> Homo sapiens


<220> 
<223> Neutrophil defensin 3 Homo sapiens

<400> 20
Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      
Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          
Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              
Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  
Asp Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  
Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  

<210> 21
<211> 208
<212> PRT
<213> Homo sapiens


<220> 
<223> Zymogen granule protein 16 homolog B Homo sapiens

<400> 21
Met Gly Ala Gln Gly Ala Gln Glu Ser Ile Lys Ala Met Trp Arg Val 
1               5                   10                  15      
Pro Gly Thr Thr Arg Arg Pro Val Thr Gly Glu Ser Pro Gly Met His 
            20                  25                  30          
Arg Pro Glu Ala Met Leu Leu Leu Leu Thr Leu Ala Leu Leu Gly Gly 
        35                  40                  45              
Pro Thr Trp Ala Gly Lys Met Tyr Gly Pro Gly Gly Gly Lys Tyr Phe 
    50                  55                  60                  
Ser Thr Thr Glu Asp Tyr Asp His Glu Ile Thr Gly Leu Arg Val Ser 
65                  70                  75                  80  
Val Gly Leu Leu Leu Val Lys Ser Val Gln Val Lys Leu Gly Asp Ser 
                85                  90                  95      
Trp Asp Val Lys Leu Gly Ala Leu Gly Gly Asn Thr Gln Glu Val Thr 
            100                 105                 110         
Leu Gln Pro Gly Glu Tyr Ile Thr Lys Val Phe Val Ala Phe Gln Ala 
        115                 120                 125             
Phe Leu Arg Gly Met Val Met Tyr Thr Ser Lys Asp Arg Tyr Phe Tyr 
    130                 135                 140                 
Phe Gly Lys Leu Asp Gly Gln Ile Ser Ser Ala Tyr Pro Ser Gln Glu 
145                 150                 155                 160 
Gly Gln Val Leu Val Gly Ile Tyr Gly Gln Tyr Gln Leu Leu Gly Ile 
                165                 170                 175     
Lys Ser Ile Gly Phe Glu Trp Asn Tyr Pro Leu Glu Glu Pro Thr Thr 
            180                 185                 190         
Glu Pro Pro Val Asn Leu Thr Tyr Ser Ala Asn Ser Pro Val Gly Arg 
        195                 200                 205             



<210> 22
<211> 255
<212> PRT
<213> Homo sapiens


<220> 
<223> Cathepsin G Homo sapiens

<400> 22
Met Gln Pro Leu Leu Leu Leu Leu Ala Phe Leu Leu Pro Thr Gly Ala 
1               5                   10                  15      
Glu Ala Gly Glu Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg 
            20                  25                  30          
Pro Tyr Met Ala Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg 
        35                  40                  45              
Cys Gly Gly Phe Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  
Cys Trp Gly Ser Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln 
65                  70                  75                  80  
Arg Arg Glu Asn Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg 
                85                  90                  95      
His Pro Gln Tyr Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu 
            100                 105                 110         
Gln Leu Ser Arg Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala 
        115                 120                 125             
Leu Pro Arg Ala Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val 
    130                 135                 140                 
Ala Gly Trp Gly Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg 
145                 150                 155                 160 
Glu Val Gln Leu Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe 
                165                 170                 175     
Gly Ser Tyr Asp Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu 
            180                 185                 190         
Arg Lys Ala Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn 
        195                 200                 205             
Asn Val Ala His Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro 
    210                 215                 220                 
Pro Glu Val Phe Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr 
225                 230                 235                 240 
Thr Met Arg Ser Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu 
                245                 250                 255 

<210> 23
<211> 764
<212> PRT
<213> Homo sapiens


<220> 
<223> Polymeric immunoglobulin receptor Homo sapiens

<400> 23
Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile 
1               5                   10                  15      
Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu 
            20                  25                  30          
Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn 
        35                  40                  45              
Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys 
    50                  55                  60                  
Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly 
65                  70                  75                  80  
Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn 
                85                  90                  95      
Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu 
            100                 105                 110         
Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser 
        115                 120                 125             
Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu 
    130                 135                 140                 
Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln 
145                 150                 155                 160 
Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val 
                165                 170                 175     
Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg 
            180                 185                 190         
Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn 
        195                 200                 205             
Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp 
    210                 215                 220                 
Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro 
225                 230                 235                 240 
Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His 
                245                 250                 255     
Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg 
            260                 265                 270         
Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys 
        275                 280                 285             
Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys 
    290                 295                 300                 
Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala 
305                 310                 315                 320 
Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly 
                325                 330                 335     
Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile 
            340                 345                 350         
Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala 
        355                 360                 365             
Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp 
    370                 375                 380                 
Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp 
385                 390                 395                 400 
Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu 
                405                 410                 415     
Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr 
            420                 425                 430         
Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu 
        435                 440                 445             
Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu 
    450                 455                 460                 
Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val 
465                 470                 475                 480 
Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys 
                485                 490                 495     
Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly 
            500                 505                 510         
Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser 
        515                 520                 525             
Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys 
    530                 535                 540                 
Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val 
545                 550                 555                 560 
Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala 
                565                 570                 575     
Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg 
            580                 585                 590         
Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu 
        595                 600                 605             
Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser 
    610                 615                 620                 
Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Ala Leu 
625                 630                 635                 640 
Val Ser Thr Leu Val Pro Leu Gly Leu Val Leu Ala Val Gly Ala Val 
                645                 650                 655     
Ala Val Gly Val Ala Arg Ala Arg His Arg Lys Asn Val Asp Arg Val 
            660                 665                 670         
Ser Ile Arg Ser Tyr Arg Thr Asp Ile Ser Met Ser Asp Phe Glu Asn 
        675                 680                 685             
Ser Arg Glu Phe Gly Ala Asn Asp Asn Met Gly Ala Ser Ser Ile Thr 
    690                 695                 700                 
Gln Glu Thr Ser Leu Gly Gly Lys Glu Glu Phe Val Ala Thr Thr Glu 
705                 710                 715                 720 
Ser Thr Thr Glu Thr Lys Glu Pro Lys Lys Ala Lys Arg Ser Ser Lys 
                725                 730                 735     
Glu Glu Ala Glu Met Ala Tyr Lys Asp Phe Leu Leu Gln Ser Ser Thr 
            740                 745                 750         
Val Ala Ala Glu Ala Gln Asp Gly Pro Gln Glu Ala 
        755                 760                 

<210> 24
<211> 159
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunoglobulin J chain Homo sapiens

<400> 24
Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      
Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          
Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              
Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  
Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  
Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      
Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         
Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             
Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 
Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 

<210> 25
<211> 103
<212> PRT
<213> Homo sapiens


<220> 
<223> Histone H4 Homo sapiens

<400> 25
Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      
Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          
Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              
Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  
Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  
Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      
Thr Leu Tyr Gly Phe Gly Gly 
            100             

<210> 26
<211> 377
<212> PRT
<213> Homo sapiens


<220> 
<223> Mucin-7 Homo sapiens

<400> 26
Met Lys Thr Leu Pro Leu Phe Val Cys Ile Cys Ala Leu Ser Ala Cys 
1               5                   10                  15      
Phe Ser Phe Ser Glu Gly Arg Glu Arg Asp His Glu Leu Arg His Arg 
            20                  25                  30          
Arg His His His Gln Ser Pro Lys Ser His Phe Glu Leu Pro His Tyr 
        35                  40                  45              
Pro Gly Leu Leu Ala His Gln Lys Pro Phe Ile Arg Lys Ser Tyr Lys 
    50                  55                  60                  
Cys Leu His Lys Arg Cys Arg Pro Lys Leu Pro Pro Ser Pro Asn Asn 
65                  70                  75                  80  
Pro Pro Lys Phe Pro Asn Pro His Gln Pro Pro Lys His Pro Asp Lys 
                85                  90                  95      
Asn Ser Ser Val Val Asn Pro Thr Leu Val Ala Thr Thr Gln Ile Pro 
            100                 105                 110         
Ser Val Thr Phe Pro Ser Ala Ser Thr Lys Ile Thr Thr Leu Pro Asn 
        115                 120                 125             
Val Thr Phe Leu Pro Gln Asn Ala Thr Thr Ile Ser Ser Arg Glu Asn 
    130                 135                 140                 
Val Asn Thr Ser Ser Ser Val Ala Thr Leu Ala Pro Val Asn Ser Pro 
145                 150                 155                 160 
Ala Pro Gln Asp Thr Thr Ala Ala Pro Pro Thr Pro Ser Ala Thr Thr 
                165                 170                 175     
Pro Ala Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro 
            180                 185                 190         
Pro Thr Pro Ser Ala Thr Thr Gln Ala Pro Pro Ser Ser Ser Ala Pro 
        195                 200                 205             
Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Pro Ala Thr Thr Pro Ala 
    210                 215                 220                 
Pro Pro Ser Ser Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr 
225                 230                 235                 240 
Pro Ser Ala Thr Thr Pro Ala Pro Leu Ser Ser Ser Ala Pro Pro Glu 
                245                 250                 255     
Thr Thr Ala Val Pro Pro Thr Pro Ser Ala Thr Thr Leu Asp Pro Ser 
            260                 265                 270         
Ser Ala Ser Ala Pro Pro Glu Thr Thr Ala Ala Pro Pro Thr Pro Ser 
        275                 280                 285             
Ala Thr Thr Pro Ala Pro Pro Ser Ser Pro Ala Pro Gln Glu Thr Thr 
    290                 295                 300                 
Ala Ala Pro Ile Thr Thr Pro Asn Ser Ser Pro Thr Thr Leu Ala Pro 
305                 310                 315                 320 
Asp Thr Ser Glu Thr Ser Ala Ala Pro Thr His Gln Thr Thr Thr Ser 
                325                 330                 335     
Val Thr Thr Gln Thr Thr Thr Thr Lys Gln Pro Thr Ser Ala Pro Gly 
            340                 345                 350         
Gln Asn Lys Ile Ser Arg Phe Leu Leu Tyr Met Lys Asn Leu Leu Asn 
        355                 360                 365             
Arg Ile Ile Asp Asp Met Val Glu Gln 
    370                 375         

<210> 27
<211> 5762
<212> PRT
<213> Homo sapiens


<220> 
<223> Mucin-5B Homo sapiens

<400> 27
Met Gly Ala Pro Ser Ala Cys Arg Thr Leu Val Leu Ala Leu Ala Ala 
1               5                   10                  15      
Met Leu Val Val Pro Gln Ala Glu Thr Gln Gly Pro Val Glu Pro Ser 
            20                  25                  30          
Trp Glu Asn Ala Gly His Thr Met Asp Gly Gly Ala Pro Thr Ser Ser 
        35                  40                  45              
Pro Thr Arg Arg Val Ser Phe Val Pro Pro Val Thr Val Phe Pro Ser 
    50                  55                  60                  
Leu Ser Pro Leu Asn Pro Ala His Asn Gly Arg Val Cys Ser Thr Trp 
65                  70                  75                  80  
Gly Asp Phe His Tyr Lys Thr Phe Asp Gly Asp Val Phe Arg Phe Pro 
                85                  90                  95      
Gly Leu Cys Asn Tyr Val Phe Ser Glu His Cys Arg Ala Ala Tyr Glu 
            100                 105                 110         
Asp Phe Asn Val Gln Leu Arg Arg Gly Leu Val Gly Ser Arg Pro Val 
        115                 120                 125             
Val Thr Arg Val Val Ile Lys Ala Gln Gly Leu Val Leu Glu Ala Ser 
    130                 135                 140                 
Asn Gly Ser Val Leu Ile Asn Gly Gln Arg Glu Glu Leu Pro Tyr Ser 
145                 150                 155                 160 
Arg Thr Gly Leu Leu Val Glu Gln Ser Gly Asp Tyr Ile Lys Val Ser 
                165                 170                 175     
Ile Arg Leu Val Leu Thr Phe Leu Trp Asn Gly Glu Asp Ser Ala Leu 
            180                 185                 190         
Leu Glu Leu Asp Pro Lys Tyr Ala Asn Gln Thr Cys Gly Leu Cys Gly 
        195                 200                 205             
Asp Phe Asn Gly Leu Pro Ala Phe Asn Glu Phe Tyr Ala His Asn Ala 
    210                 215                 220                 
Arg Leu Thr Pro Leu Gln Phe Gly Asn Leu Gln Lys Leu Asp Gly Pro 
225                 230                 235                 240 
Thr Glu Gln Cys Pro Asp Pro Leu Pro Leu Pro Ala Gly Asn Cys Thr 
                245                 250                 255     
Asp Glu Glu Gly Ile Cys His Arg Thr Leu Leu Gly Pro Ala Phe Ala 
            260                 265                 270         
Glu Cys His Ala Leu Val Asp Ser Thr Ala Tyr Leu Ala Ala Cys Ala 
        275                 280                 285             
Gln Asp Leu Cys Arg Cys Pro Thr Cys Pro Cys Ala Thr Phe Val Glu 
    290                 295                 300                 
Tyr Ser Arg Gln Cys Ala His Ala Gly Gly Gln Pro Arg Asn Trp Arg 
305                 310                 315                 320 
Cys Pro Glu Leu Cys Pro Arg Thr Cys Pro Leu Asn Met Gln His Gln 
                325                 330                 335     
Glu Cys Gly Ser Pro Cys Thr Asp Thr Cys Ser Asn Pro Gln Arg Ala 
            340                 345                 350         
Gln Leu Cys Glu Asp His Cys Val Asp Gly Cys Phe Cys Pro Pro Gly 
        355                 360                 365             
Thr Val Leu Asp Asp Ile Thr His Ser Gly Cys Leu Pro Leu Gly Gln 
    370                 375                 380                 
Cys Pro Cys Thr His Gly Gly Arg Thr Tyr Ser Pro Gly Thr Ser Phe 
385                 390                 395                 400 
Asn Thr Thr Cys Ser Ser Cys Thr Cys Ser Gly Gly Leu Trp Gln Cys 
                405                 410                 415     
Gln Asp Leu Pro Cys Pro Gly Thr Cys Ser Val Gln Gly Gly Ala His 
            420                 425                 430         
Ile Ser Thr Tyr Asp Glu Lys Leu Tyr Asp Leu His Gly Asp Cys Ser 
        435                 440                 445             
Tyr Val Leu Ser Lys Lys Cys Ala Asp Ser Ser Phe Thr Val Leu Ala 
    450                 455                 460                 
Glu Leu Arg Lys Cys Gly Leu Thr Asp Asn Glu Asn Cys Leu Lys Ala 
465                 470                 475                 480 
Val Thr Leu Ser Leu Asp Gly Gly Asp Thr Ala Ile Arg Val Gln Ala 
                485                 490                 495     
Asp Gly Gly Val Phe Leu Asn Ser Ile Tyr Thr Gln Leu Pro Leu Ser 
            500                 505                 510         
Ala Ala Asn Ile Thr Leu Phe Thr Pro Ser Ser Phe Phe Ile Val Val 
        515                 520                 525             
Gln Thr Gly Leu Gly Leu Gln Leu Leu Val Gln Leu Val Pro Leu Met 
    530                 535                 540                 
Gln Val Phe Val Arg Leu Asp Pro Ala His Gln Gly Gln Met Cys Gly 
545                 550                 555                 560 
Leu Cys Gly Asn Phe Asn Gln Asn Gln Ala Asp Asp Phe Thr Ala Leu 
                565                 570                 575     
Ser Gly Val Val Glu Ala Thr Gly Ala Ala Phe Ala Asn Thr Trp Lys 
            580                 585                 590         
Ala Gln Ala Ala Cys Ala Asn Ala Arg Asn Ser Phe Glu Asp Pro Cys 
        595                 600                 605             
Ser Leu Ser Val Glu Asn Glu Asn Tyr Ala Arg His Trp Cys Ser Arg 
    610                 615                 620                 
Leu Thr Asp Pro Asn Ser Ala Phe Ser Arg Cys His Ser Ile Ile Asn 
625                 630                 635                 640 
Pro Lys Pro Phe His Ser Asn Cys Met Phe Asp Thr Cys Asn Cys Glu 
                645                 650                 655     
Arg Ser Glu Asp Cys Leu Cys Ala Ala Leu Ser Ser Tyr Val His Ala 
            660                 665                 670         
Cys Ala Ala Lys Gly Val Gln Leu Ser Asp Trp Arg Asp Gly Val Cys 
        675                 680                 685             
Thr Lys Tyr Met Gln Asn Cys Pro Lys Ser Gln Arg Tyr Ala Tyr Val 
    690                 695                 700                 
Val Asp Ala Cys Gln Pro Thr Cys Arg Gly Leu Ser Glu Ala Asp Val 
705                 710                 715                 720 
Thr Cys Ser Val Ser Phe Val Pro Val Asp Gly Cys Thr Cys Pro Ala 
                725                 730                 735     
Gly Thr Phe Leu Asn Asp Ala Gly Ala Cys Val Pro Ala Gln Glu Cys 
            740                 745                 750         
Pro Cys Tyr Ala His Gly Thr Val Leu Ala Pro Gly Glu Val Val His 
        755                 760                 765             
Asp Glu Gly Ala Val Cys Ser Cys Thr Gly Gly Lys Leu Ser Cys Leu 
    770                 775                 780                 
Gly Ala Ser Leu Gln Lys Ser Thr Gly Cys Ala Ala Pro Met Val Tyr 
785                 790                 795                 800 
Leu Asp Cys Ser Asn Ser Ser Ala Gly Thr Pro Gly Ala Glu Cys Leu 
                805                 810                 815     
Arg Ser Cys His Thr Leu Asp Val Gly Cys Phe Ser Thr His Cys Val 
            820                 825                 830         
Ser Gly Cys Val Cys Pro Pro Gly Leu Val Ser Asp Gly Ser Gly Gly 
        835                 840                 845             
Cys Ile Ala Glu Glu Asp Cys Pro Cys Val His Asn Glu Ala Thr Tyr 
    850                 855                 860                 
Lys Pro Gly Glu Thr Ile Arg Val Asp Cys Asn Thr Cys Thr Cys Arg 
865                 870                 875                 880 
Asn Arg Arg Trp Glu Cys Ser His Arg Leu Cys Leu Gly Thr Cys Val 
                885                 890                 895     
Ala Tyr Gly Asp Gly His Phe Ile Thr Phe Asp Gly Asp Arg Tyr Ser 
            900                 905                 910         
Phe Glu Gly Ser Cys Glu Tyr Ile Leu Ala Gln Asp Tyr Cys Gly Asp 
        915                 920                 925             
Asn Thr Thr His Gly Thr Phe Arg Ile Val Thr Glu Asn Ile Pro Cys 
    930                 935                 940                 
Gly Thr Thr Gly Thr Thr Cys Ser Lys Ala Ile Lys Leu Phe Val Glu 
945                 950                 955                 960 
Ser Tyr Glu Leu Ile Leu Gln Glu Gly Thr Phe Lys Ala Val Ala Arg 
                965                 970                 975     
Gly Pro Gly Gly Asp Pro Pro Tyr Lys Ile Arg Tyr Met Gly Ile Phe 
            980                 985                 990         
Leu Val Ile Glu Thr His Gly Met Ala Val Ser Trp Asp Arg Lys Thr 
        995                 1000                1005            
Ser Val Phe Ile Arg Leu His Gln Asp Tyr Lys Gly Arg Val Cys Gly 
    1010                1015                1020                
Leu Cys Gly Asn Phe Asp Asp Asn Ala Ile Asn Asp Phe Ala Thr Arg 
1025                1030                1035                1040
Ser Arg Ser Val Val Gly Asp Ala Leu Glu Phe Gly Asn Ser Trp Lys 
                1045                1050                1055    
Leu Ser Pro Ser Cys Pro Asp Ala Leu Ala Pro Lys Asp Pro Cys Thr 
            1060                1065                1070        
Ala Asn Pro Phe Arg Lys Ser Trp Ala Gln Lys Gln Cys Ser Ile Leu 
        1075                1080                1085            
His Gly Pro Thr Phe Ala Ala Cys Arg Ser Gln Val Asp Ser Thr Lys 
    1090                1095                1100                
Tyr Tyr Glu Ala Cys Val Asn Asp Ala Cys Ala Cys Asp Ser Gly Gly 
1105                1110                1115                1120
Asp Cys Glu Cys Phe Cys Thr Ala Val Ala Ala Tyr Ala Gln Ala Cys 
                1125                1130                1135    
His Asp Ala Gly Leu Cys Val Ser Trp Arg Thr Pro Asp Thr Cys Pro 
            1140                1145                1150        
Leu Phe Cys Asp Phe Tyr Asn Pro His Gly Gly Cys Glu Trp His Tyr 
        1155                1160                1165            
Gln Pro Cys Gly Ala Pro Cys Leu Lys Thr Cys Arg Asn Pro Ser Gly 
    1170                1175                1180                
His Cys Leu Val Asp Leu Pro Gly Leu Glu Gly Cys Tyr Pro Lys Cys 
1185                1190                1195                1200
Pro Pro Ser Gln Pro Phe Phe Asn Glu Asp Gln Met Lys Cys Val Ala 
                1205                1210                1215    
Gln Cys Gly Cys Tyr Asp Lys Asp Gly Asn Tyr Tyr Asp Val Gly Ala 
            1220                1225                1230        
Arg Val Pro Thr Ala Glu Asn Cys Gln Ser Cys Asn Cys Thr Pro Ser 
        1235                1240                1245            
Gly Ile Gln Cys Ala His Ser Leu Glu Ala Cys Thr Cys Thr Tyr Glu 
    1250                1255                1260                
Asp Arg Thr Tyr Ser Tyr Gln Asp Val Ile Tyr Asn Thr Thr Asp Gly 
1265                1270                1275                1280
Leu Gly Ala Cys Leu Ile Ala Ile Cys Gly Ser Asn Gly Thr Ile Ile 
                1285                1290                1295    
Arg Lys Ala Val Ala Cys Pro Gly Thr Pro Ala Thr Thr Pro Phe Thr 
            1300                1305                1310        
Phe Thr Thr Ala Trp Val Pro His Ser Thr Thr Ser Pro Ala Leu Pro 
        1315                1320                1325            
Val Ser Thr Val Cys Val Arg Glu Val Cys Arg Trp Ser Ser Trp Tyr 
    1330                1335                1340                
Asn Gly His Arg Pro Glu Pro Gly Leu Gly Gly Gly Asp Phe Glu Thr 
1345                1350                1355                1360
Phe Glu Asn Leu Arg Gln Arg Gly Tyr Gln Val Cys Pro Val Leu Ala 
                1365                1370                1375    
Asp Ile Glu Cys Arg Ala Ala Gln Leu Pro Asp Met Pro Leu Glu Glu 
            1380                1385                1390        
Leu Gly Gln Gln Val Asp Cys Asp Arg Met Arg Gly Leu Met Cys Ala 
        1395                1400                1405            
Asn Ser Gln Gln Ser Pro Pro Leu Cys His Asp Tyr Glu Leu Arg Val 
    1410                1415                1420                
Leu Cys Cys Glu Tyr Val Pro Cys Gly Pro Ser Pro Ala Pro Gly Thr 
1425                1430                1435                1440
Ser Pro Gln Pro Ser Leu Ser Ala Ser Thr Glu Pro Ala Val Pro Thr 
                1445                1450                1455    
Pro Thr Gln Thr Thr Ala Thr Glu Lys Thr Thr Leu Trp Val Thr Pro 
            1460                1465                1470        
Ser Ile Arg Ser Thr Ala Ala Leu Thr Ser Gln Thr Gly Ser Ser Ser 
        1475                1480                1485            
Gly Pro Val Thr Val Thr Pro Ser Ala Pro Gly Thr Thr Thr Cys Gln 
    1490                1495                1500                
Pro Arg Cys Gln Trp Thr Glu Trp Phe Asp Glu Asp Tyr Pro Lys Ser 
1505                1510                1515                1520
Glu Gln Leu Gly Gly Asp Val Glu Ser Tyr Asp Lys Ile Arg Ala Ala 
                1525                1530                1535    
Gly Gly His Leu Cys Gln Gln Pro Lys Asp Ile Glu Cys Gln Ala Glu 
            1540                1545                1550        
Ser Phe Pro Asn Trp Thr Leu Ala Gln Val Gly Gln Lys Val His Cys 
        1555                1560                1565            
Asp Val His Phe Gly Leu Val Cys Arg Asn Trp Glu Gln Glu Gly Val 
    1570                1575                1580                
Phe Lys Met Cys Tyr Asn Tyr Arg Ile Arg Val Leu Cys Cys Ser Asp 
1585                1590                1595                1600
Asp His Cys Arg Gly Arg Ala Thr Thr Pro Pro Pro Thr Thr Glu Leu 
                1605                1610                1615    
Glu Thr Ala Thr Thr Thr Thr Thr Gln Ala Leu Phe Ser Thr Pro Gln 
            1620                1625                1630        
Pro Thr Ser Ser Pro Gly Leu Thr Arg Ala Pro Pro Ala Ser Thr Thr 
        1635                1640                1645            
Ala Val Pro Thr Leu Ser Glu Gly Leu Thr Ser Pro Arg Tyr Thr Ser 
    1650                1655                1660                
Thr Leu Gly Thr Ala Thr Thr Gly Gly Pro Thr Thr Pro Ala Gly Ser 
1665                1670                1675                1680
Thr Glu Pro Thr Val Pro Gly Val Ala Thr Ser Thr Leu Pro Thr Arg 
                1685                1690                1695    
Ser Ala Leu Pro Gly Thr Thr Gly Ser Leu Gly Thr Trp Arg Pro Ser 
            1700                1705                1710        
Gln Pro Pro Thr Leu Ala Pro Thr Thr Met Ala Thr Ser Arg Ala Arg 
        1715                1720                1725            
Pro Thr Gly Thr Ala Ser Thr Ala Ser Lys Glu Pro Leu Thr Thr Ser 
    1730                1735                1740                
Leu Ala Pro Thr Leu Thr Ser Glu Leu Ser Thr Ser Gln Ala Glu Thr 
1745                1750                1755                1760
Ser Thr Pro Arg Thr Glu Thr Thr Met Ser Pro Leu Thr Asn Thr Thr 
                1765                1770                1775    
Thr Ser Gln Gly Thr Thr Arg Cys Gln Pro Lys Cys Glu Trp Thr Glu 
            1780                1785                1790        
Trp Phe Asp Val Asp Phe Pro Thr Ser Gly Val Ala Gly Gly Asp Met 
        1795                1800                1805            
Glu Thr Phe Glu Asn Ile Arg Ala Ala Gly Gly Lys Met Cys Trp Ala 
    1810                1815                1820                
Pro Lys Ser Ile Glu Cys Arg Ala Glu Asn Tyr Pro Glu Val Ser Ile 
1825                1830                1835                1840
Asp Gln Val Gly Gln Val Leu Thr Cys Ser Leu Glu Thr Gly Leu Thr 
                1845                1850                1855    
Cys Lys Asn Glu Asp Gln Thr Gly Arg Phe Asn Met Cys Phe Asn Tyr 
            1860                1865                1870        
Asn Val Arg Val Leu Cys Cys Asp Asp Tyr Ser His Cys Pro Ser Thr 
        1875                1880                1885            
Pro Ala Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr 
    1890                1895                1900                
Trp Ile Leu Thr Lys Pro Thr Thr Thr Ala Thr Thr Thr Ala Ser Thr 
1905                1910                1915                1920
Gly Ser Thr Ala Thr Pro Thr Ser Thr Leu Arg Thr Ala Pro Pro Pro 
                1925                1930                1935    
Lys Val Leu Thr Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys 
            1940                1945                1950        
Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu 
        1955                1960                1965            
Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Val Thr Pro Ile Pro 
    1970                1975                1980                
Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr 
1985                1990                1995                2000
Pro Thr Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr 
                2005                2010                2015    
Ala His Thr Ser Thr Val Leu Thr Ala Thr Ala Thr Thr Thr Gly Ala 
            2020                2025                2030        
Thr Gly Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr 
        2035                2040                2045            
Thr Lys Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser 
    2050                2055                2060                
Ser Ser Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr 
2065                2070                2075                2080
Thr Thr Pro Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro 
                2085                2090                2095    
Gly Thr Thr His Thr Ala Thr Val Leu Thr Thr Thr Thr Thr Thr Val 
            2100                2105                2110        
Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly 
        2115                2120                2125            
Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly 
    2130                2135                2140                
Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro 
2145                2150                2155                2160
Val Leu Thr Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Asn Thr Val 
                2165                2170                2175    
Thr Pro Ser Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn 
            2180                2185                2190        
Thr Met Ala Thr Thr His Gly Arg Ser Leu Pro Pro Ser Ser Pro His 
        2195                2200                2205            
Thr Val Arg Thr Ala Trp Thr Ser Ala Thr Ser Gly Ile Leu Gly Thr 
    2210                2215                2220                
Thr His Ile Thr Glu Pro Ser Thr Val Thr Ser His Thr Leu Ala Ala 
2225                2230                2235                2240
Thr Thr Gly Thr Thr Gln His Ser Thr Pro Ala Leu Ser Ser Pro His 
                2245                2250                2255    
Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr 
            2260                2265                2270        
Pro Gly His Thr Thr Ala Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro 
        2275                2280                2285            
Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro Ser Ser Pro Thr Ser Ala 
    2290                2295                2300                
Pro Ile Thr Thr Val Val Thr Met Gly Cys Glu Pro Gln Cys Ala Trp 
2305                2310                2315                2320
Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly 
                2325                2330                2335    
Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys 
            2340                2345                2350        
Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly Val 
        2355                2360                2365            
Pro Leu Arg Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly 
    2370                2375                2380                
Leu Val Cys Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe 
2385                2390                2395                2400
Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser 
                2405                2410                2415    
Thr Pro Ala Thr Ser Ser Thr Ala Met Pro Ser Ser Thr Pro Gly Thr 
            2420                2425                2430        
Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Glu Ser 
        2435                2440                2445            
Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile 
    2450                2455                2460                
Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr Gly Ser 
2465                2470                2475                2480
Thr Ala Thr Ala Ser Ser Thr Gln Ala Thr Ala Gly Thr Pro His Val 
                2485                2490                2495    
Ser Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys Ala Thr Pro 
            2500                2505                2510        
Phe Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr 
        2515                2520                2525            
Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro Ser Ser Ser 
    2530                2535                2540                
Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala 
2545                2550                2555                2560
Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His Thr 
                2565                2570                2575    
Ser Thr Val Leu Thr Thr Thr Ala Thr Thr Thr Gly Ala Thr Gly Ser 
            2580                2585                2590        
Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys Val 
        2595                2600                2605            
Leu Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro 
    2610                2615                2620                
Gly Thr Ala Arg Thr Leu Pro Val Trp Ile Ser Thr Thr Thr Thr Pro 
2625                2630                2635                2640
Thr Thr Arg Gly Ser Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr 
                2645                2650                2655    
His Thr Pro Thr Val Leu Thr Thr Thr Thr Thr Thr Val Ala Thr Gly 
            2660                2665                2670        
Ser Met Ala Thr Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro 
        2675                2680                2685            
Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr 
    2690                2695                2700                
Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro Ile Pro Pro Val Leu Thr 
2705                2710                2715                2720
Thr Thr Ala Thr Thr Pro Ala Ala Thr Ser Ser Thr Val Thr Pro Ser 
                2725                2730                2735    
Ser Ala Leu Gly Thr Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala 
            2740                2745                2750        
Thr Thr His Gly Arg Ser Leu Ser Pro Ser Ser Pro His Thr Val Arg 
        2755                2760                2765            
Thr Ala Trp Thr Ser Ala Thr Ser Gly Thr Leu Gly Thr Thr His Ile 
    2770                2775                2780                
Thr Glu Pro Ser Thr Gly Thr Ser His Thr Pro Ala Ala Thr Thr Gly 
2785                2790                2795                2800
Thr Thr Gln His Ser Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser 
                2805                2810                2815    
Arg Thr Thr Glu Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His 
            2820                2825                2830        
Thr Arg Ala Thr Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr 
        2835                2840                2845            
Arg Thr Ser Thr Leu Leu Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr 
    2850                2855                2860                
Thr Val Val Thr Met Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp 
2865                2870                2875                2880
Leu Asp Tyr Ser Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp 
                2885                2890                2895    
Thr Tyr Ser Asn Ile Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro 
            2900                2905                2910        
Leu Gly Leu Glu Cys Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Arg 
        2915                2920                2925            
Glu Leu Gly Gln Val Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys 
    2930                2935                2940                
Arg Asn Arg Glu Gln Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu 
2945                2950                2955                2960
Ile Arg Val Phe Cys Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala 
                2965                2970                2975    
Thr Ser Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile 
            2980                2985                2990        
Leu Thr Glu Gln Thr Thr Ala Ala Thr Thr Thr Ala Thr Thr Gly Ser 
        2995                3000                3005            
Thr Ala Ile Pro Ser Ser Thr Pro Gly Thr Ala Pro Pro Pro Lys Val 
    3010                3015                3020                
Leu Thr Ser Thr Ala Thr Thr Pro Thr Ala Thr Ser Ser Lys Ala Thr 
3025                3030                3035                3040
Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro Val Leu Thr Ser 
                3045                3050                3055    
Thr Ala Thr Lys Ser Thr Ala Thr Ser Phe Thr Pro Ile Pro Ser Phe 
            3060                3065                3070        
Thr Leu Gly Thr Thr Gly Thr Leu Pro Glu Gln Thr Thr Thr Pro Met 
        3075                3080                3085            
Ala Thr Met Ser Thr Ile His Pro Ser Ser Thr Pro Glu Thr Thr His 
    3090                3095                3100                
Thr Ser Thr Val Leu Thr Thr Lys Ala Thr Thr Thr Arg Ala Thr Ser 
3105                3110                3115                3120
Ser Met Ser Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr 
                3125                3130                3135    
Glu Leu Thr Thr Ala Ala Thr Thr Thr Ala Ala Thr Gly Pro Thr Ala 
            3140                3145                3150        
Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser 
        3155                3160                3165            
Thr Thr Ala Thr Val Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser 
    3170                3175                3180                
Ser Thr Arg Ala Thr Ala Gly Thr Leu Lys Val Leu Thr Ser Thr Ala 
3185                3190                3195                3200
Thr Thr Pro Thr Val Ile Ser Ser Arg Ala Thr Pro Ser Ser Ser Pro 
                3205                3210                3215    
Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro 
            3220                3225                3230        
Thr Ala Thr Ser Val Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Ala 
        3235                3240                3245            
Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr 
    3250                3255                3260                
Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His Thr Ser Thr Val Leu 
3265                3270                3275                3280
Thr Thr Thr Thr Thr Thr Thr Arg Ala Thr Gly Ser Val Ala Thr Pro 
                3285                3290                3295    
Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr 
            3300                3305                3310        
Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser Pro Gly Thr Ala Leu 
        3315                3320                3325            
Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Arg Gly 
    3330                3335                3340                
Ser Thr Val Thr Pro Ser Ser Ile Pro Gly Thr Thr His Thr Ala Thr 
3345                3350                3355                3360
Val Leu Thr Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr 
                3365                3370                3375    
Pro Ser Ser Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr 
            3380                3385                3390        
Thr Ala Thr Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser 
        3395                3400                3405            
Thr Pro Gly Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr 
    3410                3415                3420                
Thr Pro Ala Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly 
3425                3430                3435                3440
Thr Thr His Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly 
                3445                3450                3455    
Arg Ser Leu Pro Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr 
            3460                3465                3470        
Ser Ala Thr Ser Gly Ile Leu Gly Thr Thr His Ile Thr Glu Pro Ser 
        3475                3480                3485            
Thr Val Thr Ser His Thr Pro Ala Ala Thr Thr Ser Thr Thr Gln His 
    3490                3495                3500                
Ser Thr Pro Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu 
3505                3510                3515                3520
Ser Pro Pro Ser Pro Gly Thr Thr Thr Pro Gly His Thr Arg Gly Thr 
                3525                3530                3535    
Ser Arg Thr Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr 
            3540                3545                3550        
Leu Leu Pro Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr 
        3555                3560                3565            
Thr Gly Cys Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser 
    3570                3575                3580                
Tyr Pro Met Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn 
3585                3590                3595                3600
Ile Arg Ala Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu 
                3605                3610                3615    
Cys Arg Ala Gln Ala Gln Pro Gly Val Pro Leu Arg Glu Leu Gly Gln 
            3620                3625                3630        
Val Val Glu Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu 
        3635                3640                3645            
Gln Val Gly Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe 
    3650                3655                3660                
Cys Cys Asn Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr 
3665                3670                3675                3680
Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Lys Leu 
                3685                3690                3695    
Thr Thr Thr Ala Thr Thr Thr Glu Ser Thr Gly Ser Thr Ala Thr Pro 
            3700                3705                3710        
Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Pro Ser Thr Thr 
        3715                3720                3725            
Ala Thr Val Thr Val Pro Thr Gly Ser Thr Ala Thr Ala Ser Ser Thr 
    3730                3735                3740                
Gln Ala Thr Ala Gly Thr Pro His Val Ser Thr Thr Ala Thr Thr Pro 
3745                3750                3755                3760
Thr Val Thr Ser Ser Lys Ala Thr Pro Phe Ser Ser Pro Gly Thr Ala 
                3765                3770                3775    
Thr Ala Leu Pro Ala Leu Arg Ser Thr Ala Thr Thr Pro Thr Ala Thr 
            3780                3785                3790        
Ser Phe Thr Ala Ile Pro Ser Ser Ser Leu Gly Thr Thr Trp Thr Arg 
        3795                3800                3805            
Leu Ser Gln Thr Thr Thr Pro Thr Ala Thr Met Ser Thr Ala Thr Pro 
    3810                3815                3820                
Ser Ser Thr Pro Glu Thr Ala His Thr Ser Thr Val Leu Thr Thr Thr 
3825                3830                3835                3840
Ala Thr Thr Thr Arg Ala Thr Gly Ser Val Ala Thr Pro Ser Ser Thr 
                3845                3850                3855    
Pro Gly Thr Ala His Thr Thr Lys Val Pro Thr Thr Thr Thr Thr Gly 
            3860                3865                3870        
Phe Thr Val Thr Pro Ser Ser Ser Pro Gly Thr Ala Arg Thr Pro Pro 
        3875                3880                3885            
Val Trp Ile Ser Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val 
    3890                3895                3900                
Thr Pro Ser Ser Val Pro Gly Thr Thr His Thr Pro Thr Val Leu Thr 
3905                3910                3915                3920
Thr Thr Thr Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser 
                3925                3930                3935    
Ser Thr Gln Thr Ser Gly Thr Pro Pro Ser Leu Ile Thr Thr Ala Thr 
            3940                3945                3950        
Thr Ile Thr Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly 
        3955                3960                3965            
Thr Thr Pro Ile Pro Pro Val Leu Thr Thr Thr Ala Thr Thr Pro Ala 
    3970                3975                3980                
Ala Thr Ser Ser Thr Val Thr Pro Ser Ser Ala Leu Gly Thr Thr His 
3985                3990                3995                4000
Thr Pro Pro Val Pro Asn Thr Thr Ala Thr Thr His Gly Arg Ser Leu 
                4005                4010                4015    
Ser Pro Ser Ser Pro His Thr Val Arg Thr Ala Trp Thr Ser Ala Thr 
            4020                4025                4030        
Ser Gly Thr Leu Gly Thr Thr His Ile Thr Glu Pro Ser Thr Gly Thr 
        4035                4040                4045            
Ser His Thr Pro Ala Ala Thr Thr Gly Thr Thr Gln His Ser Thr Pro 
    4050                4055                4060                
Ala Leu Ser Ser Pro His Pro Ser Ser Arg Thr Thr Glu Ser Pro Pro 
4065                4070                4075                4080
Ser Pro Gly Thr Thr Thr Pro Gly His Thr Thr Ala Thr Ser Arg Thr 
                4085                4090                4095    
Thr Ala Thr Ala Thr Pro Ser Lys Thr Arg Thr Ser Thr Leu Leu Pro 
            4100                4105                4110        
Ser Ser Pro Thr Ser Ala Pro Ile Thr Thr Val Val Thr Thr Gly Cys 
        4115                4120                4125            
Glu Pro Gln Cys Ala Trp Ser Glu Trp Leu Asp Tyr Ser Tyr Pro Met 
    4130                4135                4140                
Pro Gly Pro Ser Gly Gly Asp Phe Asp Thr Tyr Ser Asn Ile Arg Ala 
4145                4150                4155                4160
Ala Gly Gly Ala Val Cys Glu Gln Pro Leu Gly Leu Glu Cys Arg Ala 
                4165                4170                4175    
Gln Ala Gln Pro Gly Val Pro Leu Gly Glu Leu Gly Gln Val Val Glu 
            4180                4185                4190        
Cys Ser Leu Asp Phe Gly Leu Val Cys Arg Asn Arg Glu Gln Val Gly 
        4195                4200                4205            
Lys Phe Lys Met Cys Phe Asn Tyr Glu Ile Arg Val Phe Cys Cys Asn 
    4210                4215                4220                
Tyr Gly His Cys Pro Ser Thr Pro Ala Thr Ser Ser Thr Ala Met Pro 
4225                4230                4235                4240
Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr 
                4245                4250                4255    
Ala Thr Thr Thr Ala Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr 
            4260                4265                4270        
Pro Gly Thr Ala Pro Pro Pro Lys Val Leu Thr Ser Pro Ala Thr Thr 
        4275                4280                4285            
Pro Thr Ala Thr Ser Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr 
    4290                4295                4300                
Ala Thr Thr Leu Pro Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala 
4305                4310                4315                4320
Thr Ser Val Thr Pro Ile Pro Ser Ser Thr Leu Gly Thr Thr Gly Thr 
                4325                4330                4335    
Leu Pro Glu Gln Thr Thr Thr Pro Val Ala Thr Met Ser Thr Ile His 
            4340                4345                4350        
Pro Ser Ser Thr Pro Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr 
        4355                4360                4365            
Lys Ala Thr Thr Thr Arg Ala Thr Ser Ser Thr Ser Thr Pro Ser Ser 
    4370                4375                4380                
Thr Pro Gly Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Ala Ala Thr 
4385                4390                4395                4400
Thr Thr Ala Ala Thr Gly Pro Thr Ala Thr Pro Ser Ser Thr Pro Gly 
                4405                4410                4415    
Thr Thr Trp Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala 
            4420                4425                4430        
Ser Thr Gly Ser Thr Ala Thr Pro Ser Ser Thr Pro Gly Thr Thr Trp 
        4435                4440                4445            
Ile Leu Thr Glu Pro Ser Thr Thr Ala Thr Val Thr Val Pro Thr Gly 
    4450                4455                4460                
Ser Thr Ala Thr Ala Ser Ser Thr Gln Ala Thr Ala Gly Thr Pro His 
4465                4470                4475                4480
Val Ser Thr Thr Ala Thr Thr Pro Thr Val Thr Ser Ser Lys Ala Thr 
                4485                4490                4495    
Pro Ser Ser Ser Pro Gly Thr Ala Thr Ala Leu Pro Ala Leu Arg Ser 
            4500                4505                4510        
Thr Ala Thr Thr Pro Thr Ala Thr Ser Phe Thr Ala Ile Pro Ser Ser 
        4515                4520                4525            
Ser Leu Gly Thr Thr Trp Thr Arg Leu Ser Gln Thr Thr Thr Pro Thr 
    4530                4535                4540                
Ala Thr Met Ser Thr Ala Thr Pro Ser Ser Thr Pro Glu Thr Val His 
4545                4550                4555                4560
Thr Ser Thr Val Leu Thr Ala Thr Ala Thr Thr Thr Gly Ala Thr Gly 
                4565                4570                4575    
Ser Val Ala Thr Pro Ser Ser Thr Pro Gly Thr Ala His Thr Thr Lys 
            4580                4585                4590        
Val Pro Thr Thr Thr Thr Thr Gly Phe Thr Ala Thr Pro Ser Ser Ser 
        4595                4600                4605            
Pro Gly Thr Ala Leu Thr Pro Pro Val Trp Ile Ser Thr Thr Thr Thr 
    4610                4615                4620                
Pro Thr Thr Thr Thr Pro Thr Thr Ser Gly Ser Thr Val Thr Pro Ser 
4625                4630                4635                4640
Ser Ile Pro Gly Thr Thr His Thr Ala Arg Val Leu Thr Thr Thr Thr 
                4645                4650                4655    
Thr Thr Val Ala Thr Gly Ser Met Ala Thr Pro Ser Ser Ser Thr Gln 
            4660                4665                4670        
Thr Ser Gly Thr Pro Pro Ser Leu Thr Thr Thr Ala Thr Thr Ile Thr 
        4675                4680                4685            
Ala Thr Gly Ser Thr Thr Asn Pro Ser Ser Thr Pro Gly Thr Thr Pro 
    4690                4695                4700                
Ile Thr Pro Val Leu Thr Ser Thr Ala Thr Thr Pro Ala Ala Thr Ser 
4705                4710                4715                4720
Ser Lys Ala Thr Ser Ser Ser Ser Pro Arg Thr Ala Thr Thr Leu Pro 
                4725                4730                4735    
Val Leu Thr Ser Thr Ala Thr Lys Ser Thr Ala Thr Ser Phe Thr Pro 
            4740                4745                4750        
Ile Pro Ser Ser Thr Leu Trp Thr Thr Trp Thr Val Pro Ala Gln Thr 
        4755                4760                4765            
Thr Thr Pro Met Ser Thr Met Ser Thr Ile His Thr Ser Ser Thr Pro 
    4770                4775                4780                
Glu Thr Thr His Thr Ser Thr Val Leu Thr Thr Thr Ala Thr Met Thr 
4785                4790                4795                4800
Arg Ala Thr Asn Ser Thr Ala Thr Pro Ser Ser Thr Leu Gly Thr Thr 
                4805                4810                4815    
Arg Ile Leu Thr Glu Leu Thr Thr Thr Ala Thr Thr Thr Ala Ala Thr 
            4820                4825                4830        
Gly Ser Thr Ala Thr Leu Ser Ser Thr Pro Gly Thr Thr Trp Ile Leu 
        4835                4840                4845            
Thr Glu Pro Ser Thr Ile Ala Thr Val Met Val Pro Thr Gly Ser Thr 
    4850                4855                4860                
Ala Thr Ala Ser Ser Thr Leu Gly Thr Ala His Thr Pro Lys Val Val 
4865                4870                4875                4880
Thr Thr Met Ala Thr Met Pro Thr Ala Thr Ala Ser Thr Val Pro Ser 
                4885                4890                4895    
Ser Ser Thr Val Gly Thr Thr Arg Thr Pro Ala Val Leu Pro Ser Ser 
            4900                4905                4910        
Leu Pro Thr Phe Ser Val Ser Thr Val Ser Ser Ser Val Leu Thr Thr 
        4915                4920                4925            
Leu Arg Pro Thr Gly Phe Pro Ser Ser His Phe Ser Thr Pro Cys Phe 
    4930                4935                4940                
Cys Arg Ala Phe Gly Gln Phe Phe Ser Pro Gly Glu Val Ile Tyr Asn 
4945                4950                4955                4960
Lys Thr Asp Arg Ala Gly Cys His Phe Tyr Ala Val Cys Asn Gln His 
                4965                4970                4975    
Cys Asp Ile Asp Arg Phe Gln Gly Ala Cys Pro Thr Ser Pro Pro Pro 
            4980                4985                4990        
Val Ser Ser Ala Pro Leu Ser Ser Pro Ser Pro Ala Pro Gly Cys Asp 
        4995                5000                5005            
Asn Ala Ile Pro Leu Arg Gln Val Asn Glu Thr Trp Thr Leu Glu Asn 
    5010                5015                5020                
Cys Thr Val Ala Arg Cys Val Gly Asp Asn Arg Val Val Leu Leu Asp 
5025                5030                5035                5040
Pro Lys Pro Val Ala Asn Val Thr Cys Val Asn Lys His Leu Pro Ile 
                5045                5050                5055    
Lys Val Ser Asp Pro Ser Gln Pro Cys Asp Phe His Tyr Glu Cys Glu 
            5060                5065                5070        
Cys Ile Cys Ser Met Trp Gly Gly Ser His Tyr Ser Thr Phe Asp Gly 
        5075                5080                5085            
Thr Ser Tyr Thr Phe Arg Gly Asn Cys Thr Tyr Val Leu Met Arg Glu 
    5090                5095                5100                
Ile His Ala Arg Phe Gly Asn Leu Ser Leu Tyr Leu Asp Asn His Tyr 
5105                5110                5115                5120
Cys Thr Ala Ser Ala Thr Ala Ala Ala Ala Arg Cys Pro Arg Ala Leu 
                5125                5130                5135    
Ser Ile His Tyr Lys Ser Met Asp Ile Val Leu Thr Val Thr Met Val 
            5140                5145                5150        
His Gly Lys Glu Glu Gly Leu Ile Leu Phe Asp Gln Ile Pro Val Ser 
        5155                5160                5165            
Ser Gly Phe Ser Lys Asn Gly Val Leu Val Ser Val Leu Gly Thr Thr 
    5170                5175                5180                
Thr Met Arg Val Asp Ile Pro Ala Leu Gly Val Ser Val Thr Phe Asn 
5185                5190                5195                5200
Gly Gln Val Phe Gln Ala Arg Leu Pro Tyr Ser Leu Phe His Asn Asn 
                5205                5210                5215    
Thr Glu Gly Gln Cys Gly Thr Cys Thr Asn Asn Gln Arg Asp Asp Cys 
            5220                5225                5230        
Leu Gln Arg Asp Gly Thr Thr Ala Ala Ser Cys Lys Asp Met Ala Lys 
        5235                5240                5245            
Thr Trp Leu Val Pro Asp Ser Arg Lys Asp Gly Cys Trp Ala Pro Thr 
    5250                5255                5260                
Gly Thr Pro Pro Thr Ala Ser Pro Ala Ala Pro Val Ser Ser Thr Pro 
5265                5270                5275                5280
Thr Pro Thr Pro Cys Pro Pro Gln Pro Leu Cys Asp Leu Met Leu Ser 
                5285                5290                5295    
Gln Val Phe Ala Glu Cys His Asn Leu Val Pro Pro Gly Pro Phe Phe 
            5300                5305                5310        
Asn Ala Cys Ile Ser Asp His Cys Arg Gly Arg Leu Glu Val Pro Cys 
        5315                5320                5325            
Gln Ser Leu Glu Ala Tyr Ala Glu Leu Cys Arg Ala Arg Gly Val Cys 
    5330                5335                5340                
Ser Asp Trp Arg Gly Ala Thr Gly Gly Leu Cys Asp Leu Thr Cys Pro 
5345                5350                5355                5360
Pro Thr Lys Val Tyr Lys Pro Cys Gly Pro Ile Gln Pro Ala Thr Cys 
                5365                5370                5375    
Asn Ser Arg Asn Gln Ser Pro Gln Leu Glu Gly Met Ala Glu Gly Cys 
            5380                5385                5390        
Phe Cys Pro Glu Asp Gln Ile Leu Phe Asn Ala His Met Gly Ile Cys 
        5395                5400                5405            
Val Gln Ala Cys Pro Cys Val Gly Pro Asp Gly Phe Pro Lys Phe Pro 
    5410                5415                5420                
Gly Glu Arg Trp Val Ser Asn Cys Gln Ser Cys Val Cys Asp Glu Gly 
5425                5430                5435                5440
Ser Val Ser Val Gln Cys Lys Pro Leu Pro Cys Asp Ala Gln Gly Gln 
                5445                5450                5455    
Pro Pro Pro Cys Asn Arg Pro Gly Phe Val Thr Val Thr Arg Pro Arg 
            5460                5465                5470        
Ala Glu Asn Pro Cys Cys Pro Glu Thr Val Cys Val Cys Asn Thr Thr 
        5475                5480                5485            
Thr Cys Pro Gln Ser Leu Pro Val Cys Pro Pro Gly Gln Glu Ser Ile 
    5490                5495                5500                
Cys Thr Gln Glu Glu Gly Asp Cys Cys Pro Thr Phe Arg Cys Arg Pro 
5505                5510                5515                5520
Gln Leu Cys Ser Tyr Asn Gly Thr Phe Tyr Gly Val Gly Ala Thr Phe 
                5525                5530                5535    
Pro Gly Ala Leu Pro Cys His Met Cys Thr Cys Leu Ser Gly Asp Thr 
            5540                5545                5550        
Gln Asp Pro Thr Val Gln Cys Gln Glu Asp Ala Cys Asn Asn Thr Thr 
        5555                5560                5565            
Cys Pro Gln Gly Phe Glu Tyr Lys Arg Val Ala Gly Gln Cys Cys Gly 
    5570                5575                5580                
Glu Cys Val Gln Thr Ala Cys Leu Thr Pro Asp Gly Gln Pro Val Gln 
5585                5590                5595                5600
Leu Asn Glu Thr Trp Val Asn Ser His Val Asp Asn Cys Thr Val Tyr 
                5605                5610                5615    
Leu Cys Glu Ala Glu Gly Gly Val His Leu Leu Thr Pro Gln Pro Ala 
            5620                5625                5630        
Ser Cys Pro Asp Val Ser Ser Cys Arg Gly Ser Leu Arg Lys Thr Gly 
        5635                5640                5645            
Cys Cys Tyr Ser Cys Glu Glu Asp Ser Cys Gln Val Arg Ile Asn Thr 
    5650                5655                5660                
Thr Ile Leu Trp His Gln Gly Cys Glu Thr Glu Val Asn Ile Thr Phe 
5665                5670                5675                5680
Cys Glu Gly Ser Cys Pro Gly Ala Ser Lys Tyr Ser Ala Glu Ala Gln 
                5685                5690                5695    
Ala Met Gln His Gln Cys Thr Cys Cys Gln Glu Arg Arg Val His Glu 
            5700                5705                5710        
Glu Thr Val Pro Leu His Cys Pro Asn Gly Ser Ala Ile Leu His Thr 
        5715                5720                5725            
Tyr Thr His Val Asp Glu Cys Gly Cys Thr Pro Phe Cys Val Pro Ala 
    5730                5735                5740                
Pro Met Ala Pro Pro His Thr Arg Gly Phe Pro Ala Gln Glu Ala Thr 
5745                5750                5755                5760
Ala Val 
        

<210> 28
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> nanobody

<400> 28
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Glu Trp Thr 
            20                  25                  30          
His Met His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Ala Ile Ala Ser Ser Gly Ala Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Asn Val Lys Asp Trp Gly Ser Gln Asp Arg Tyr Tyr Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser 
        115                 120 

<210> 29
<211> 311
<212> PRT
<213> Renilla reniformis


<220> 
<223> Luciferase

<400> 29
Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      
Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          
Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              
Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  
Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  
Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      
His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         
Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             
Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 
Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 
Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     
Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         
Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             
Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 
Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 
Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     
Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         
Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             
Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 
Arg Val Leu Lys Asn Glu Gln 
305                 310     

<210> 30
<211> 485
<212> PRT
<213> Escherichia coli


<220> 
<223> alkaline phosphatase

<400> 30
Met Phe Leu Phe Phe Asn Val Phe Val His Gly Glu Asn Lys Val Lys 
1               5                   10                  15      
Gln Ser Thr Ile Ala Leu Ala Leu Leu Ser Leu Leu Phe Thr Pro Val 
            20                  25                  30          
Thr Lys Ala Arg Thr Pro Glu Met Pro Val Leu Glu Asn Arg Ala Ala 
        35                  40                  45              
Gln Gly Asp Ile Thr Ala Ser Gly Gly Ala Arg Arg Leu Thr Gly Asp 
    50                  55                  60                  
Gln Thr Ala Ala Leu Arg Asp Ser Leu Ser Asp Lys Pro Ala Lys Asn 
65                  70                  75                  80  
Ile Ile Leu Leu Ile Gly Asp Gly Met Gly Asp Ser Glu Ile Thr Ala 
                85                  90                  95      
Ala Arg Asn Tyr Ala Glu Gly Ala Gly Gly Phe Phe Lys Gly Ile Asp 
            100                 105                 110         
Ala Leu Pro Leu Thr Gly Gln Tyr Thr His Tyr Ala Leu Asn Lys Lys 
        115                 120                 125             
Thr Gly Lys Pro Asp Tyr Val Thr Asp Ser Ala Ala Ser Ala Thr Ala 
    130                 135                 140                 
Trp Ser Thr Gly Val Lys Thr Tyr Asn Gly Ala Leu Gly Val Asp Ile 
145                 150                 155                 160 
His Glu Lys Asp His Pro Thr Ile Leu Glu Met Ala Lys Ala Ala Gly 
                165                 170                 175     
Leu Ala Thr Gly Asn Val Ser Thr Ala Glu Leu Gln Asp Ala Thr Pro 
            180                 185                 190         
Ala Ala Leu Val Ala His Val Thr Ser Arg Lys Cys Tyr Gly Pro Ser 
        195                 200                 205             
Ala Thr Ser Glu Lys Cys Pro Gly Asn Ala Leu Glu Lys Gly Gly Lys 
    210                 215                 220                 
Gly Ser Ile Thr Glu Gln Leu Leu Asn Ala Arg Ala Asp Val Thr Leu 
225                 230                 235                 240 
Gly Gly Gly Ala Lys Thr Phe Ala Glu Thr Ala Thr Ala Gly Glu Trp 
                245                 250                 255     
Gln Gly Lys Thr Leu Arg Glu Gln Ala Gln Ala Arg Gly Tyr Gln Leu 
            260                 265                 270         
Val Ser Asp Ala Ala Ser Leu Asn Ser Val Thr Glu Ala Asn Gln Gln 
        275                 280                 285             
Lys Pro Leu Leu Gly Leu Phe Ala Asp Gly Asn Met Pro Val Arg Trp 
    290                 295                 300                 
Leu Gly Pro Lys Ala Thr Tyr His Gly Asn Ile Asp Lys Pro Ala Val 
305                 310                 315                 320 
Thr Cys Thr Pro Asn Pro Gln Arg Asn Asp Ser Val Pro Thr Leu Ala 
                325                 330                 335     
Gln Met Thr Asp Lys Ala Ile Glu Leu Leu Ser Lys Asn Glu Lys Gly 
            340                 345                 350         
Phe Phe Leu Gln Val Glu Gly Ala Ser Ile Asp Lys Gln Asp His Ala 
        355                 360                 365             
Ala Asn Pro Cys Gly Gln Ile Gly Glu Thr Val Asp Leu Asp Glu Ala 
    370                 375                 380                 
Val Gln Arg Ala Leu Glu Phe Ala Lys Lys Asp Gly Asn Thr Leu Val 
385                 390                 395                 400 
Ile Val Thr Ala Asp His Ala His Ala Ser Gln Ile Val Ala Pro Asp 
                405                 410                 415     
Thr Lys Ala Pro Gly Leu Thr Gln Ala Leu Asn Thr Lys Asp Gly Ala 
            420                 425                 430         
Val Met Val Met Ser Tyr Gly Asn Ser Glu Glu Asp Ser Gln Glu His 
        435                 440                 445             
Thr Gly Ser Gln Leu Arg Ile Ala Ala Tyr Gly Pro His Ala Ala Asn 
    450                 455                 460                 
Val Val Gly Leu Thr Asp Gln Thr Asp Leu Phe Tyr Thr Met Lys Ala 
465                 470                 475                 480 
Ala Leu Gly Leu Lys 
                485 

