                         SEQUENCE LISTING

<110>  A2 BIOTHERAPEUTICS, INC.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING EGFR POSITIVE CANCERS

<130>  A2BI-021/02WO 331656-2067

<150>  US 63/230,632
<151>  2021-08-06

<150>  US 63/105,639
<151>  2020-10-26

<150>  US 63/068,249
<151>  2020-08-20

<160>  919   

<170>  PatentIn version 3.5

<210>  1
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  2
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Ser 
625             


<210>  3
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Leu Ser 
                405 


<210>  4
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  5
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Gly Gln Lys 
    130                 135                 140                 


Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu 
145                 150                 155                 160 


Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly 
                165                 170                 175     


Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala 
            180                 185                 190         


Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys 
        195                 200                 205             


Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu 
    210                 215                 220                 


Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr 
225                 230                 235                 240 


Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val 
                245                 250                 255     


Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu 
            260                 265                 270         


Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys 
        275                 280                 285             


Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
    290                 295                 300                 


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
305                 310                 315                 320 


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
                325                 330                 335     


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
            340                 345                 350         


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
        355                 360                 365             


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
    370                 375                 380                 


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
385                 390                 395                 400 


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
                405                 410                 415     


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
            420                 425                 430         


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
        435                 440                 445             


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
    450                 455                 460                 


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
465                 470                 475                 480 


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
                485                 490                 495     


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
            500                 505                 510         


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
        515                 520                 525             


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
    530                 535                 540                 


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
545                 550                 555                 560 


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
                565                 570                 575     


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
            580                 585                 590         


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
        595                 600                 605             


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg 
    610                 615                 620                 


Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu 
625                 630                 635                 640 


Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln 
                645                 650                 655     


Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val 
            660                 665                 670         


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro 
        675                 680                 685             


Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu 
    690                 695                 700                 


Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
705                 710                 715                 720 


Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys 
                725                 730                 735     


Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys 
            740                 745                 750         


Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr 
        755                 760                 765             


Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu 
    770                 775                 780                 


Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
785                 790                 795                 800 


Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu 
                805                 810                 815     


Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro 
            820                 825                 830         


Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His 
        835                 840                 845             


Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr 
    850                 855                 860                 


Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser 
865                 870                 875                 880 


Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile 
                885                 890                 895     


Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser 
            900                 905                 910         


Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg 
        915                 920                 925             


Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu 
    930                 935                 940                 


Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu 
945                 950                 955                 960 


Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln 
                965                 970                 975     


Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser 
            980                 985                 990         


Leu Ser Ala Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
        995                 1000                 1005             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1010                 1015                 1020             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1025                 1030                 1035             


Asp Thr  Phe Leu Pro Val Pro  Gly Glu Trp Leu Val  Trp Lys Gln 
    1040                 1045                 1050             


Ser Cys  Ser Ser Thr Ser Ser  Thr His Ser Ala Ala  Ala Ser Leu 
    1055                 1060                 1065             


Gln Cys  Pro Ser Gln Val Leu  Pro Pro Ala Ser Pro  Glu Gly Glu 
    1070                 1075                 1080             


Thr Val  Ala Asp Leu Gln Thr  Gln 
    1085                 1090     


<210>  6
<211>  1136
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Gly Glu Trp Leu Val  Trp Lys Gln 
    1085                 1090                 1095             


Ser Cys  Ser Ser Thr Ser Ser  Thr His Ser Ala Ala  Ala Ser Leu 
    1100                 1105                 1110             


Gln Cys  Pro Ser Gln Val Leu  Pro Pro Ala Ser Pro  Glu Gly Glu 
    1115                 1120                 1125             


Thr Val  Ala Asp Leu Gln Thr  Gln 
    1130                 1135     


<210>  7
<211>  1157
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr 
1               5                   10                  15      


Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val 
            20                  25                  30          


Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu 
        35                  40                  45              


Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr 
    50                  55                  60                  


Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys 
65                  70                  75                  80  


Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg 
                85                  90                  95      


Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg 
            100                 105                 110         


Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln 
        115                 120                 125             


Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly 
    130                 135                 140                 


Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile 
145                 150                 155                 160 


Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser 
                165                 170                 175     


Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu 
            180                 185                 190         


Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys 
        195                 200                 205             


Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met 
    210                 215                 220                 


Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys 
225                 230                 235                 240 


Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg 
                245                 250                 255     


Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys 
            260                 265                 270         


Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly 
        275                 280                 285             


Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
    290                 295                 300                 


His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro 
305                 310                 315                 320 


Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro 
                325                 330                 335     


Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu 
            340                 345                 350         


Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu 
        355                 360                 365             


Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser 
    370                 375                 380                 


Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu 
385                 390                 395                 400 


Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu 
                405                 410                 415     


Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly 
            420                 425                 430         


Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala 
        435                 440                 445             


Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly 
    450                 455                 460                 


Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg 
465                 470                 475                 480 


Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe 
                485                 490                 495     


Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln 
            500                 505                 510         


Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln 
        515                 520                 525             


Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala 
    530                 535                 540                 


Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala 
545                 550                 555                 560 


Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr 
                565                 570                 575     


Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
            580                 585                 590         


Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
        595                 600                 605             


Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Lys Arg 
    610                 615                 620                 


Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu Val Glu Pro Leu Thr 
625                 630                 635                 640 


Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu 
                645                 650                 655     


Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr 
            660                 665                 670         


Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro 
        675                 680                 685             


Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys 
    690                 695                 700                 


Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His 
705                 710                 715                 720 


Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile 
                725                 730                 735     


Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His 
            740                 745                 750         


Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile 
        755                 760                 765             


Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp 
    770                 775                 780                 


Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile 
785                 790                 795                 800 


Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr 
                805                 810                 815     


His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser 
            820                 825                 830         


Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly 
        835                 840                 845             


Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly 
    850                 855                 860                 


Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu 
865                 870                 875                 880 


Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys 
                885                 890                 895     


Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile 
            900                 905                 910         


Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile 
        915                 920                 925             


Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe 
    930                 935                 940                 


Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala 
945                 950                 955                 960 


Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr 
                965                 970                 975     


Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser 
            980                 985                 990         


Thr Val Ala Cys Ile Asp Arg Asn  Gly Leu Gln Ser Cys  Pro Ile Lys 
        995                 1000                 1005             


Glu Asp  Ser Phe Leu Gln Arg  Tyr Ser Ser Asp Pro  Thr Gly Ala 
    1010                 1015                 1020             


Leu Thr  Glu Asp Ser Ile Asp  Asp Thr Phe Leu Pro  Val Pro Glu 
    1025                 1030                 1035             


Tyr Ile  Asn Gln Ser Val Pro  Lys Arg Pro Ala Gly  Ser Val Gln 
    1040                 1045                 1050             


Asn Pro  Val Tyr His Asn Gln  Pro Leu Asn Pro Ala  Pro Ser Arg 
    1055                 1060                 1065             


Asp Pro  His Tyr Gln Asp Pro  His Ser Thr Ala Val  Gly Asn Pro 
    1070                 1075                 1080             


Glu Tyr  Leu Asn Thr Val Gln  Pro Thr Cys Val Asn  Ser Thr Phe 
    1085                 1090                 1095             


Asp Ser  Pro Ala His Trp Ala  Gln Lys Gly Ser His  Gln Ile Ser 
    1100                 1105                 1110             


Leu Asp  Asn Pro Asp Tyr Gln  Gln Asp Phe Phe Pro  Lys Glu Ala 
    1115                 1120                 1125             


Lys Pro  Asn Gly Ile Phe Lys  Gly Ser Thr Ala Glu  Asn Ala Glu 
    1130                 1135                 1140             


Tyr Leu  Arg Val Ala Pro Gln  Ser Ser Glu Phe Ile  Gly Ala 
    1145                 1150                 1155         


<210>  8
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr 
            20                  25                  30          


Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser 
        35                  40                  45              


Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly 
    50                  55                  60                  


Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
65                  70                  75                  80  


Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
                85                  90                  95      


Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
            100                 105                 110         


Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
        115                 120                 125             


Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
    130                 135                 140                 


Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
145                 150                 155                 160 


Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
                165                 170                 175     


Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
            180                 185                 190         


Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
        195                 200                 205             


Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
    210                 215                 220                 


Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
225                 230                 235                 240 


Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
                245                 250                 255     


Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
            260                 265                 270         


Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
        275                 280                 285             


Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
    290                 295                 300                 


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
305                 310                 315                 320 


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
                325                 330                 335     


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
            340                 345                 350         


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
        355                 360                 365             


Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
    370                 375                 380                 


Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
385                 390                 395                 400 


Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
                405                 410                 415     


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            420                 425                 430         


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        435                 440                 445             


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    450                 455                 460                 


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
465                 470                 475                 480 


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                485                 490                 495     


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            500                 505                 510         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe 
        515                 520                 525             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    530                 535                 540                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
545                 550                 555                 560 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                565                 570                 575     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            580                 585                 590         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        595                 600                 605             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    610                 615                 620                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
625                 630                 635                 640 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                645                 650                 655     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            660                 665                 670         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        675                 680                 685             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    690                 695                 700                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
705                 710                 715                 720 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                725                 730                 735     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            740                 745                 750         


Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu 
        755                 760                 765             


Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp 
    770                 775                 780                 


Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln 
785                 790                 795                 800 


Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp 
                805                 810                 815     


Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys 
            820                 825                 830         


Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu 
        835                 840                 845             


Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr 
    850                 855                 860                 


Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val 
865                 870                 875                 880 


Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His 
                885                 890                 895     


Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys 
            900                 905                 910         


Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala 
        915                 920                 925             


Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    930                 935                 940             


<210>  9
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-478 EGFR (VH-VL scFv Format)

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Val 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
            180                 185                 190         


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Glu 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  10
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-479 EGFR (VL-VH scFv Format)

<400>  10

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp 
                165                 170                 175     


Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly 
    210                 215                 220                 


Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  11
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-480 EGFR (VH-VL scFv format)

<400>  11

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  12
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-481 EGFR (VL-VH scFv Format)

<400>  12

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu 
145                 150                 155                 160 


Tyr Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp 
                165                 170                 175     


Met Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu 
            180                 185                 190         


Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Leu Thr Val Ser Ser 
                245         


<210>  13
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-482 EGFR (VH-VL scFv Format)

<400>  13

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Val Val Met Thr Gln 
    130                 135                 140                 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
                165                 170                 175     


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Leu Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  14
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-483 EGFR (VL-VH scFv Format)

<400>  14

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
145                 150                 155                 160 


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
                165                 170                 175     


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 


<210>  15
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-486 EGFR (VH-VL scFv Format)

<400>  15

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Leu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr 
                165                 170                 175     


Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
            180                 185                 190         


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  16
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-487 EGFR (VH-VL scFv Format)

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser His Ile Phe Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  17
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-488 EGFR (VH-VL scFv Format)

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  18
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-489 EGFR scFv

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
            180                 185                 190         


Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Ala Glu Ile Lys 
                245 


<210>  19
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT478, CT479

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  20
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT480, CT481

<400>  20

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  21
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT482, CT483

<400>  21

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT486

<400>  22

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  23
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT487

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT488

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT478, CT479

<400>  25

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT480, CT481

<400>  26

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  27
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT482, CT483

<400>  27

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT486

<400>  28

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  29
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT487

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Ile Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT488

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  31

Thr Tyr Gly Met His 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  32

Glu Tyr Pro Ile His 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  33

His Tyr Asp Met Ser 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  34

Asn Tyr Gly Val His 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  35

Ser His Trp Met His 
1               5   


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  36

Ser Gly Asp Tyr Tyr Trp Thr 
1               5           


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  37

Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  38

Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  39

Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  40

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
1               5                   10                  15      


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  41

Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  42

His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  43

Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  44

Asp Arg Tyr Asp Ser Leu Phe Asp Tyr 
1               5                   


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  45

Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe 
1               5                   10          


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  46

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10      


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  47

Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr 
1               5                   10          


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  48

Asp Arg Val Thr Gly Ala Phe Asp Ile 
1               5                   


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  49

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Val 
1               5                   10      


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  50

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  51

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  52

Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
1               5                   10      


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  53

Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr 
1               5                   10  


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  54

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L2

<400>  55

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L2

<400>  56

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L2

<400>  57

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L2

<400>  58

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L2

<400>  59

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  60

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  61

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  62

Ser Gln Ser Thr His Val Leu Thr 
1               5               


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  63

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  64

Gln Gln Trp Ser Ser His Ile Phe Thr 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  65

Gln His Phe Asp His Leu Pro Leu Ala 
1               5                   


<210>  66
<211>  45
<212>  PRT
<213>  Unknown

<220>
<223>  CD8alpha hinge

<400>  66

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  67
<211>  135
<212>  DNA
<213>  Unknown

<220>
<223>  CD8alpha hinge

<400>  67
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  68
<211>  41
<212>  PRT
<213>  Unknown

<220>
<223>  CD28 hinge

<400>  68

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  69
<211>  123
<212>  DNA
<213>  Unknown

<220>
<223>  CD28 hinge

<400>  69
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  70
<211>  27
<212>  PRT
<213>  Unknown

<220>
<223>  CD28 transmembrane domain

<400>  70

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  71
<211>  81
<212>  DNA
<213>  Unknown

<220>
<223>  CD28 transmembrane domain

<400>  71
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210>  72
<211>  25
<212>  PRT
<213>  Unknown

<220>
<223>  IL-2Rbeta transmembrane domain

<400>  72

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  73
<211>  75
<212>  DNA
<213>  Unknown

<220>
<223>  IL-2Rbeta transmembrane domain

<400>  73
attccgtggc tcggccacct cctcgtgggc ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210>  74
<211>  112
<212>  PRT
<213>  Unknown

<220>
<223>  CD3zeta activation domain

<400>  74

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  75
<211>  336
<212>  DNA
<213>  Unknown

<220>
<223>  CD3zeta activation domain

<400>  75
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  76
<211>  43
<212>  PRT
<213>  Unknown

<220>
<223>  CD3zeta activation domain

<400>  76

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu His Met Gln Ala Leu Pro Pro Arg 
        35                  40              


<210>  77
<211>  129
<212>  DNA
<213>  Unknown

<220>
<223>  CD3zeta activation domain

<400>  77
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttgcacat gcaggccctg      120

ccccctcgc                                                              129


<210>  78
<211>  41
<212>  PRT
<213>  Unknown

<220>
<223>  CD28 co-stimulatory domain

<400>  78

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  79
<211>  123
<212>  DNA
<213>  Unknown

<220>
<223>  CD28 co-stimulatory domain

<400>  79
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  80
<211>  23
<212>  PRT
<213>  Unknown

<220>
<223>  TCR alpha transmembrane domain

<400>  80

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  81
<211>  69
<212>  DNA
<213>  Unknown

<220>
<223>  TCR alpha transmembrane domain

<400>  81
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg       60

cggctgtgg                                                               69


<210>  82
<211>  23
<212>  PRT
<213>  Unknown

<220>
<223>  TCR beta transmembrane domain

<400>  82

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  83
<211>  69
<212>  DNA
<213>  Unknown

<220>
<223>  TCR beta transmembrane domain

<400>  83
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc       60

ctcgtgctg                                                               69


<210>  84
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  TCR beta intracellular domain

<400>  84

Met Ala Met Val Lys Arg Lys Asp Ser Arg 
1               5                   10  


<210>  85
<211>  30
<212>  DNA
<213>  Unknown

<220>
<223>  TCR beta intracellular domain

<400>  85
atggccatgg tcaagagaaa ggattccaga                                        30


<210>  86
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  87
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         


<210>  88
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ser Trp Pro Arg Arg Leu Leu Leu Arg Tyr Leu Phe Pro Ala Leu 
1               5                   10                  15      


Leu Leu His Gly Leu Gly Glu Gly Ser Ala Leu Leu His Pro Asp Ser 
            20                  25                  30          


Arg Ser His Pro Arg Ser Leu Glu Lys Ser Ala Trp Arg Ala Phe Lys 
        35                  40                  45              


Glu Ser Gln Cys His His Met Leu Lys His Leu His Asn Gly Ala Arg 
    50                  55                  60                  


Ile Thr Val Gln Met Pro Pro Thr Ile Glu Gly His Trp Val Ser Thr 
65                  70                  75                  80  


Gly Cys Glu Val Arg Ser Gly Pro Glu Phe Ile Thr Arg Ser Tyr Arg 
                85                  90                  95      


Phe Tyr His Asn Asn Thr Phe Lys Ala Tyr Gln Phe Tyr Tyr Gly Ser 
            100                 105                 110         


Asn Arg Cys Thr Asn Pro Thr Tyr Thr Leu Ile Ile Arg Gly Lys Ile 
        115                 120                 125             


Arg Leu Arg Gln Ala Ser Trp Ile Ile Arg Gly Gly Thr Glu Ala Asp 
    130                 135                 140                 


Tyr Gln Leu His Asn Val Gln Val Ile Cys His Thr Glu Ala Val Ala 
145                 150                 155                 160 


Glu Lys Leu Gly Gln Gln Val Asn Arg Thr Cys Pro Gly Phe Leu Ala 
                165                 170                 175     


Asp Gly Gly Pro Trp Val Gln Asp Val Ala Tyr Asp Leu Trp Arg Glu 
            180                 185                 190         


Glu Asn Gly Cys Glu Cys Thr Lys Ala Val Asn Phe Ala Met His Glu 
        195                 200                 205             


Leu Gln Leu Ile Arg Val Glu Lys Gln Tyr Leu His His Asn Leu Asp 
    210                 215                 220                 


His Leu Val Glu Glu Leu Phe Leu Gly Asp Ile His Thr Asp Ala Thr 
225                 230                 235                 240 


Gln Arg Met Phe Tyr Arg Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn 
                245                 250                 255     


Ala Lys Asn His Asp His Ala Cys Ile Ala Cys Arg Ile Ile Tyr Arg 
            260                 265                 270         


Ser Asp Glu His His Pro Pro Ile Leu Pro Pro Lys Ala Asp Leu Thr 
        275                 280                 285             


Ile Gly Leu His Gly Glu Trp Val Ser Gln Arg Cys Glu Val Arg Pro 
    290                 295                 300                 


Glu Val Leu Phe Leu Thr Arg His Phe Ile Phe His Asp Asn Asn Asn 
305                 310                 315                 320 


Thr Trp Glu Gly His Tyr Tyr His Tyr Ser Asp Pro Val Cys Lys His 
                325                 330                 335     


Pro Thr Phe Ser Ile Tyr Ala Arg Gly Arg Tyr Ser Arg Gly Val Leu 
            340                 345                 350         


Ser Ser Arg Val Met Gly Gly Thr Glu Phe Val Phe Lys Val Asn His 
        355                 360                 365             


Met Lys Val Thr Pro Met Asp Ala Ala Thr Ala Ser Leu Leu Asn Val 
    370                 375                 380                 


Phe Asn Gly Asn Glu Cys Gly Ala Glu Gly Ser Trp Gln Val Gly Ile 
385                 390                 395                 400 


Gln Gln Asp Val Thr His Thr Asn Gly Cys Val Ala Leu Gly Ile Lys 
                405                 410                 415     


Leu Pro His Thr Glu Tyr Glu Ile Phe Lys Met Glu Gln Asp Ala Arg 
            420                 425                 430         


Gly Arg Tyr Leu Leu Phe Asn Gly Gln Arg Pro Ser Asp Gly Ser Ser 
        435                 440                 445             


Pro Asp Arg Pro Glu Lys Arg Ala Thr Ser Tyr Gln Met Pro Leu Val 
    450                 455                 460                 


Gln Cys Ala Ser Ser Ser Pro Arg Ala Glu Asp Leu Ala Glu Asp Ser 
465                 470                 475                 480 


Gly Ser Ser Leu Tyr Gly Arg Ala Pro Gly Arg His Thr Trp Ser Leu 
                485                 490                 495     


Leu Leu Ala Ala Leu Ala Cys Leu Val Pro Leu Leu His Trp Asn Ile 
            500                 505                 510         


Arg Arg 
        


<210>  89
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-001765 PA2.1 scFv (mouse)

<400>  89

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  90
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002159 PA2.1.8 scFv (humanized)

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  91
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002160 PA2.1.9 scFv (humanized)

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  92
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002161 PA2.1.10 scFv (humanized)

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  93
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002162 PA2.1.14 scFv (humanized)

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  94
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002163 PA2.1.18 scFv (humanized)

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Met Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys His Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  95
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002164 BB7.2 scFv (mouse)

<400>  95

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Leu Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  96
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002165 BB7.2.1 scFv (humanized)

<400>  96

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Asp Ser Val Ser Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Lys Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Pro 
225                 230                 235                 240 


Gly Thr Lys Val Asp Ile Lys 
                245         


<210>  97
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002166 BB7.2.2 scFv (humanized)

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  98
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002167 BB7.2.3 scFv (humanized)

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  99
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002168 BB7.2.5 scFv (humanized)

<400>  99

Gln Val Thr Leu Lys Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Met Asp Thr Ser Phe 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  100
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002169 BB7.2.6 scFv (humanized)

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Met Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L1

<400>  101

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L2

<400>  102

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L3

<400>  103

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H1

<400>  104

Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile His 
1               5                   10          


<210>  105
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H2

<400>  105

Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly Lys 
        


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H3

<400>  106

Glu Glu Ile Thr Tyr Ala Met Asp Tyr 
1               5                   


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L1

<400>  107

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  108
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L2

<400>  108

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L3

<400>  109

Met Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H1

<400>  110

Ser Gly Tyr Thr Phe Thr Ser Tyr His Met His 
1               5                   10      


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H2

<400>  111

Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H3

<400>  112

Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  113
<211>  670
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1

<400>  113

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Pro Ser Gln Glu Gly Pro 
                645                 650                 655     


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            660                 665                 670 


<210>  114
<211>  3229
<212>  DNA
<213>  Unknown

<220>
<223>  LILRB1

<400>  114
aaatgagttt taaaaaggct tgtccaggaa gcacatatgg gagctggtca ctctgcattt       60

tgggccctcc tggaggtgtt tagaccttcc gagagagaaa ctgagacaca tgagagggaa      120

gaaatgactc agtggtgaga ccctgtggag tcccacccac aaccagcaca ctgtgaccca      180

ctgcacaaac ctctagccca cagctcactt cctcctttaa gaagagaaga gaaaagagga      240

gaggagagga ggaacagaaa agaaaagaaa agaaaaagtg ggaaacaaat aatctaagaa      300

tgaggagaaa gcaagaagag tgaccccctt gtgggcactc cattggtttt atggcgcctc      360

tactttctgg agtttgtgta aaacaaaaat attatggtct ttgtgcacat ttacatcaag      420

ctcagcctgg gcggcacagc cagatgcgag atgcgtctct gctgatctga gtctgcctgc      480

agcatggacc tgggtcttcc ctgaagcatc tccagggctg gagggacgac tgccatgcac      540

cgagggctca tccatccaca gagcagggca gtgggaggag acgccatgac ccccatcctc      600

acggtcctga tctgtctcgg gctgagtctg ggcccccgga cccacgtgca ggcagggcac      660

ctccccaagc ccaccctctg ggctgaacca ggctctgtga tcacccaggg gagtcctgtg      720

accctcaggt gtcagggggg ccaggagacc caggagtacc gtctatatag agaaaagaaa      780

acagcaccct ggattacacg gatcccacag gagcttgtga agaagggcca gttccccatc      840

ccatccatca cctgggaaca cacagggcgg tatcgctgtt actatggtag cgacactgca      900

ggccgctcag agagcagtga ccccctggag ctggtggtga caggagccta catcaaaccc      960

accctctcag cccagcccag ccccgtggtg aactcaggag ggaatgtaac cctccagtgt     1020

gactcacagg tggcatttga tggcttcatt ctgtgtaagg aaggagaaga tgaacaccca     1080

caatgcctga actcccagcc ccatgcccgt gggtcgtccc gcgccatctt ctccgtgggc     1140

cccgtgagcc cgagtcgcag gtggtggtac aggtgctatg cttatgactc gaactctccc     1200

tatgagtggt ctctacccag tgatctcctg gagctcctgg tcctaggtgt ttctaagaag     1260

ccatcactct cagtgcagcc aggtcctatc gtggcccctg aggagaccct gactctgcag     1320

tgtggctctg atgctggcta caacagattt gttctgtata aggacgggga acgtgacttc     1380

cttcagctcg ctggcgcaca gccccaggct gggctctccc aggccaactt caccctgggc     1440

cctgtgagcc gctcctacgg gggccagtac agatgctacg gtgcacacaa cctctcctcc     1500

gagtggtcgg cccccagcga ccccctggac atcctgatcg caggacagtt ctatgacaga     1560

gtctccctct cggtgcagcc gggccccacg gtggcctcag gagagaacgt gaccctgctg     1620

tgtcagtcac agggatggat gcaaactttc cttctgacca aggagggggc agctgatgac     1680

ccatggcgtc taagatcaac gtaccaatct caaaaatacc aggctgaatt ccccatgggt     1740

cctgtgacct cagcccatgc ggggacctac aggtgctacg gctcacagag ctccaaaccc     1800

tacctgctga ctcaccccag tgaccccctg gagctcgtgg tctcaggacc gtctgggggc     1860

cccagctccc cgacaacagg ccccacctcc acatctggcc ctgaggacca gcccctcacc     1920

cccaccgggt cggatcccca gagtggtctg ggaaggcacc tgggggttgt gatcggcatc     1980

ttggtggccg tcatcctact gctcctcctc ctcctcctcc tcttcctcat cctccgacat     2040

cgacgtcagg gcaaacactg gacatcgacc cagagaaagg ctgatttcca acatcctgca     2100

ggggctgtgg ggccagagcc cacagacaga ggcctgcagt ggaggtccag cccagctgcc     2160

gatgcccagg aagaaaacct ctatgctgcc gtgaagcaca cacagcctga ggatggggtg     2220

gagatggaca ctcggagccc acacgatgaa gacccccagg cagtgacgta tgccgaggtg     2280

aaacactcca gacctaggag agaaatggcc tctcctcctt ccccactgtc tggggaattc     2340

ctggacacaa aggacagaca ggcggaagag gacaggcaga tggacactga ggctgctgca     2400

tctgaagccc cccaggatgt gacctacgcc cagctgcaca gcttgaccct cagacgggag     2460

gcaactgagc ctcctccatc ccaggaaggg ccctctccag ctgtgcccag catctacgcc     2520

actctggcca tccactagcc caggggggga cgcagacccc acactccatg gagtctggaa     2580

tgcatgggag ctgccccccc agtggacacc attggacccc acccagcctg gatctacccc     2640

aggagactct gggaactttt aggggtcact caattctgca gtataaataa ctaatgtctc     2700

tacaattttg aaataaagca acagacttct caataatcaa tgaagtagct gagaaaacta     2760

agtcagaaag tgcattaaac tgaatcacaa tgtaaatatt acacatcaag cgatgaaact     2820

ggaaaactac aagccacgaa tgaatgaatt aggaaagaaa aaaagtagga aatgaatgat     2880

cttggctttc ctataagaaa tttagggcag ggcacggtgg ctcacgcctg taattccagc     2940

actttgggag gccgaggcgg gcagatcacg agttcaggag atcgagacca tcttggccaa     3000

catggtgaaa ccctgtctct cctaaaaata caaaaattag ctggatgtgg tggcagtgcc     3060

tgtaatccca gctatttggg aggctgaggc aggagaatcg cttgaaccag ggagtcagag     3120

gtttcagtga gccaagatcg caccactgct ctccagcctg gcgacagagg gagactccat     3180

ctcaaattaa aaaaaaaaaa aaaaaagaaa gaaaaaaaaa aaaaaaaaa                 3229


<210>  115
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  115

Asn Leu Tyr Ala Ala Val 
1               5       


<210>  116
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  116

Val Thr Tyr Ala Glu Val 
1               5       


<210>  117
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  117

Val Thr Tyr Ala Gln Leu 
1               5       


<210>  118
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  immunoreceptor tyrosine-based inhibitory motif

<400>  118

Ser Ile Tyr Ala Thr Leu 
1               5       


<210>  119
<211>  35
<212>  PRT
<213>  Unknown

<220>
<223>  intracellular domain

<400>  119

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val 
        35  


<210>  120
<211>  58
<212>  PRT
<213>  Unknown

<220>
<223>  intracellular domain

<400>  120

Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
1               5                   10                  15      


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            20                  25                  30          


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        35                  40                  45              


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu 
    50                  55              


<210>  121
<211>  36
<212>  PRT
<213>  Unknown

<220>
<223>  intracellular domain

<400>  121

Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
1               5                   10                  15      


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
            20                  25                  30          


Tyr Ala Thr Leu 
        35      


<210>  122
<211>  87
<212>  PRT
<213>  Unknown

<220>
<223>  intracellular domain

<400>  122

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        35                  40                  45              


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
65                  70                  75                  80  


Asp Val Thr Tyr Ala Gln Leu 
                85          


<210>  123
<211>  88
<212>  PRT
<213>  Unknown

<220>
<223>  intracellular domain

<400>  123

Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
1               5                   10                  15      


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            20                  25                  30          


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        35                  40                  45              


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    50                  55                  60                  


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
65                  70                  75                  80  


Val Pro Ser Ile Tyr Ala Thr Leu 
                85              


<210>  124
<211>  117
<212>  PRT
<213>  Unknown

<220>
<223>  intracellular domain

<400>  124

Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
1               5                   10                  15      


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            20                  25                  30          


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        35                  40                  45              


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    50                  55                  60                  


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
65                  70                  75                  80  


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
                85                  90                  95      


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
            100                 105                 110         


Ile Tyr Ala Thr Leu 
        115         


<210>  125
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 D3D4 domain

<400>  125

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu 
            20  


<210>  126
<211>  43
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 hinge domain

<400>  126

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
        35                  40              


<210>  127
<211>  86
<212>  PRT
<213>  Unknown

<220>
<223>  Hinge-transmembrane

<400>  127

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu 
                85      


<210>  128
<211>  190
<212>  PRT
<213>  Unknown

<220>
<223>  Transmembrane-intracellular domain

<400>  128

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp 
            20                  25                  30          


Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val 
        35                  40                  45              


Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala 
    50                  55                  60                  


Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln 
65                  70                  75                  80  


Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp 
                85                  90                  95      


Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg 
            100                 105                 110         


Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr 
        115                 120                 125             


Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala 
    130                 135                 140                 


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
145                 150                 155                 160 


Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro 
                165                 170                 175     


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            180                 185                 190 


<210>  129
<211>  167
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 intracellular domain

<400>  129

Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala 
1               5                   10                  15      


Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg 
            20                  25                  30          


Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn 
        35                  40                  45              


Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met 
    50                  55                  60                  


Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
65                  70                  75                  80  


Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
                85                  90                  95      


Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu 
            100                 105                 110         


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp 
        115                 120                 125             


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
    130                 135                 140                 


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
145                 150                 155                 160 


Tyr Ala Thr Leu Ala Ile His 
                165         


<210>  130
<211>  253
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 hinge-transmembrane-intracellular domain

<400>  130

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr 
                85                  90                  95      


Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly 
            100                 105                 110         


Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala 
        115                 120                 125             


Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro 
    130                 135                 140                 


Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro 
145                 150                 155                 160 


Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu 
                165                 170                 175     


Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys 
            180                 185                 190         


Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala 
        195                 200                 205             


Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr 
    210                 215                 220                 


Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser 
225                 230                 235                 240 


Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                245                 250             


<210>  131
<211>  233
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 hinge-transmembrane-intracellular domain

<400>  131

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile 
        35                  40                  45              


Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu 
    50                  55                  60                  


Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg 
65                  70                  75                  80  


Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr 
                85                  90                  95      


Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu 
            100                 105                 110         


Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val 
        115                 120                 125             


Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr 
    130                 135                 140                 


Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro 
145                 150                 155                 160 


Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala 
                165                 170                 175     


Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro 
            180                 185                 190         


Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu 
        195                 200                 205             


Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro 
    210                 215                 220                 


Ser Ile Tyr Ala Thr Leu Ala Ile His 
225                 230             


<210>  132
<211>  63
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 hinge domain

<400>  132

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    50                  55                  60              


<210>  133
<211>  23
<212>  PRT
<213>  Unknown

<220>
<223>  LILRB1 transmembrane domain

<400>  133

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu 
            20              


<210>  134
<211>  227
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  134

Xaa Asp Val Ala Tyr Asp Leu Trp Arg Glu Glu Asn Gly Cys Glu Cys 
1               5                   10                  15      


Thr Lys Ala Val Asn Phe Ala Met His Glu Leu Gln Leu Ile Arg Val 
            20                  25                  30          


Glu Lys Gln Tyr Leu His His Asn Leu Asp His Leu Val Glu Glu Leu 
        35                  40                  45              


Phe Leu Gly Asp Ile His Thr Asp Ala Thr Gln Arg Met Phe Tyr Arg 
    50                  55                  60                  


Pro Ser Ser Tyr Gln Pro Pro Leu Gln Asn Ala Lys Cys Ala Ala Glu 
65                  70                  75                  80  


Ser Ser Gly Ser Phe Gln Ile Leu Pro Gln Asp Ser Ser Glu Lys Glu 
                85                  90                  95      


Gln Asn Gly Leu Ser His Trp Cys Leu Ser Arg Pro Gly His Gln Lys 
            100                 105                 110         


Asp Trp Ala Leu Cys Ala His Ala Gly Pro Ala Thr Ala Gly Cys Pro 
        115                 120                 125             


Ser Cys Leu Trp Pro Pro Ala Glu Thr Gly Arg Lys Ala Gly Arg Thr 
    130                 135                 140                 


Ser Ser Lys Thr Val His Ala Cys Pro Gly Glu Ala Gly Thr Ser Ser 
145                 150                 155                 160 


Phe Glu Leu Phe Tyr Phe Pro Asn Cys Trp Ser Ile Glu Thr Lys Leu 
                165                 170                 175     


Lys Ile Ser Leu Asn Ala Lys Leu Ser Phe Lys Pro Arg Ala Ser Ala 
            180                 185                 190         


Pro Leu Glu Thr Gly His Arg Val Lys Ile Glu Thr Leu Ser Gln Leu 
        195                 200                 205             


Val Phe Leu Ser Phe Ile Gln Leu Cys Cys Glu Val Gln Ser Pro Leu 
    210                 215                 220                 


Ala Asn Lys 
225         


<210>  135
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  135

Pro Glu Asp Val Leu Pro Ala Leu Gln Leu Pro Ala Pro Ser Ala Glu 
1               5                   10                  15      


Cys Gln Val Glu Met Gly Phe His His Val Gly Gln Asp Gly Leu Gln 
            20                  25                  30          


Leu Pro Thr Ser Ser Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly 
        35                  40                  45              


Ile Thr Gly Val Ser His Arg Pro Pro Gly Arg His Leu Ser Asn Asp 
    50                  55                  60                  


Leu Arg Thr Thr Thr Met Pro Ala Ser Pro Val Gly Ser Ser Ile Gly 
65                  70                  75                  80  


Gln Thr Ser Thr Thr Leu Pro Ser Cys Pro Gln Arg Gln Thr 
                85                  90                  


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  136

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  137

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  138
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  138
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgt                                                                  66


<210>  139
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-478 EGFR (VH-VL scFv Format)

<400>  139
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatgggatg atggaagtta taaatactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatggt      300

attactatgg ttcggggagt tatgaaggac tactttgact actggggcca gggaaccctg      360

gtcaccgtct cctcaggcgg aggtggaagc ggagggggag gatctggcgg cggaggaagc      420

ggaggcgcca tccagttgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      480

gtcaccatca cttgccgggc aagtcaggac attagcagtg ctttagtctg gtatcagcag      540

aaaccaggga aagctcctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc      600

ccatcaaggt tcagcggcag tgaatctggg acagatttca ctctcaccat cagcagcctg      660

cagcctgaag attttgcaac ttattactgt caacagttta atagttaccc gctcactttc      720

ggcggaggga ccaaggtgga gatcaaa                                          747


<210>  140
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-479 EGFR (VL-VH scFv Format)

<400>  140
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc agtgctttag tctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtgaatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa aggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gccaggtgca gctggtggag tctgggggag gcgtggtcca gcctgggagg      420

tccctgagac tctcctgtgc agcgtctgga ttcaccttca gtacctatgg catgcactgg      480

gtccgccagg ctccaggcaa ggggctggag tgggtggcag ttatatggga tgatggaagt      540

tataaatact atggagactc cgtgaagggc cgattcacca tctccagaga caattccaag      600

aacacgctgt atctgcaaat gaacagcctg agagccgagg acacggctgt gtattactgt      660

gcgagagatg gtattactat ggttcgggga gttatgaagg actactttga ctactggggc      720

cagggaaccc tggtcaccgt ctcctca                                          747


<210>  141
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-480 EGFR (VH-VL scFv format)

<400>  141
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cctctgggta taccttcaca gaatatccaa tacactgggt gaagcaggct      120

ccaggaaagg gtttcaagtg gatgggcatg atatacaccg acattggaaa gccaacatat      180

gctgaagagt tcaagggacg gtttgccttc tctttggaga cctctgccag cactgcctat      240

ttgcagatca acaacctcaa gaatgaggac acggctacat atttctgtgt aagagatcga      300

tatgattccc tctttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tgtgatgacc      420

caaactccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      480

agtcagagcc ttgtacacag taatggaaac acctatttac attggtacct gcagaagcca      540

ggccagtctc caaagctcct gatctacaaa gtttccaacc gattttctgg ggtcccagac      600

aggttcagtg gcagtggatc agggacagat ttcacactca agatcagcag agtggaggct      660

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttccgtggac gttcggtgga      720

ggcaccaagc tggaaatcaa a                                                741


<210>  142
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-481 EGFR (VL-VH scFv Format)

<400>  142
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag atccagttgg tgcagtctgg acctgagctg      420

aagaagcctg gagagacagt caagatctcc tgcaaggcct ctgggtatac cttcacagaa      480

tatccaatac actgggtgaa gcaggctcca ggaaagggtt tcaagtggat gggcatgata      540

tacaccgaca ttggaaagcc aacatatgct gaagagttca agggacggtt tgccttctct      600

ttggagacct ctgccagcac tgcctatttg cagatcaaca acctcaagaa tgaggacacg      660

gctacatatt tctgtgtaag agatcgatat gattccctct ttgactactg gggccaaggc      720

accactctca cagtctcctc a                                                741


<210>  143
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-482 EGFR (VH-VL scFv Format)

<400>  143
gaaatgcagc tggtggagtc tgggggaggc ttcgtgaagc ctggagggtc cctgaaactc       60

tcatgtgcag cctctggatt cgctttcagt cactatgaca tgtcttgggt tcgccagact      120

ccgaagcaga ggctggagtg ggtcgcatac attgctagtg gtggtgatat cacctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgcccagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt tttactgttc acgatcctcc      300

tatggtaaca acggagatgc cctggacttc tggggtcaag gtacctcagt caccgtctcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgatgtt      420

gtgatgaccc aaactccact ctccctgcct gtcagtcttg gagatcaagc ctccatctct      480

tgcagatcta gtcagagcct tgttcacagt aatggaaaca cctatttaca ttggtacctg      540

cagaagccag gccagtctcc aaagctcctg atctacaaag tttccaaccg attttctggg      600

gtcccagaca ggttcagtgg cagtggatca gggacagatt tcacactcaa gatcagcaga      660

gtggaggctg aggatctggg agtttatttc tgctctcaaa gtacacatgt tctcacgttc      720

ggctcgggga caaagttgga aataaaa                                          747


<210>  144
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-483 EGFR (VL-VH scFv Format)

<400>  144
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgtt cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttctc      300

acgttcggct cggggacaaa gttggaaata aaaggcggag gtggaagcgg agggggagga      360

tctggcggcg gaggaagcgg aggcgaaatg cagctggtgg agtctggggg aggcttcgtg      420

aagcctggag ggtccctgaa actctcatgt gcagcctctg gattcgcttt cagtcactat      480

gacatgtctt gggttcgcca gactccgaag cagaggctgg agtgggtcgc atacattgct      540

agtggtggtg atatcaccta ctatgcagac actgtgaagg gccgattcac catctccaga      600

gacaatgccc agaacaccct gtacctgcaa atgagcagtc tgaagtctga ggacacagcc      660

atgttttact gttcacgatc ctcctatggt aacaacggag atgccctgga cttctggggt      720

caaggtacct cagtcaccgt ctcctca                                          747


<210>  145
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-486 EGFR (VH-VL scFv Format)

<400>  145
caggtgcagc tgaagcagtc cggccccggc ctggtgcagc cctcccagtc cctgtccatc       60

acctgcaccg tgtccggctt ctccctgacc aactacggcg tgcactgggt gcggcagtcc      120

cccggcaagg gcctggagtg gctgggcgtg atctggtccg gcggcaacac cgactacaac      180

acccccttca cctcccggct gtccatcaac aaggacaact ccaagtccca ggtgttcttc      240

aagatgaact ccctgcagtc caacgacacc gccatctact actgcgcccg ggccctgacc      300

tactacgact acgagttcgc ctactggggc cagggcaccc tggtgaccgt gtccgccggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catcctgctg      420

acccagtccc ccgtgatcct gtccgtgtcc cccggcgagc gggtgtcctt ctcctgccgg      480

gcctcccagt ccatcggcac caacatccac tggtaccagc agcggaccaa cggctccccc      540

cggctgctga tcaagtacgc ctccgagtcc atctccggca tcccctcccg gttctccggc      600

tccggctccg gcaccgactt caccctgtcc atcaactccg tggagtccga ggacatcgcc      660

gactactact gccagcagaa caacaactgg cccaccacct tcggcgccgg caccaagctg      720

gagctgaag                                                              729


<210>  146
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-487 EGFR (VH-VL scFv Format)

<400>  146
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc tcccactgga tgcactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatcggcgag ttcaacccct ccaacggccg gaccaactac      180

aacgagaagt tcaagtccaa ggccaccatg accgtggaca cctccaccaa caccgcctac      240

atggagctgt cctccctgcg gtccgaggac accgccgtgt actactgcgc ctcccgggac      300

tacgactacg acggccggta cttcgactac tggggccagg gcaccctggt gaccgtgtcc      360

tccggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      420

cagatgaccc agtccccctc ctccctgtcc gcctccgtgg gcgaccgggt gaccatcacc      480

tgctccgcct cctcctccgt gacctacatg tactggtacc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cacctccaac ctggcctccg gcgtgccctc ccggttctcc      600

ggctccggct ccggcaccga ctacaccttc accatctcct ccctgcagcc cgaggacatc      660

gccacctact actgccagca gtggtcctcc cacatcttca ccttcggcca gggcaccaag      720

gtggagatca ag                                                          732


<210>  147
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-488 EGFR (VH-VL scFv Format)

<400>  147
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctccgagac cctgtccctg       60

acctgcaccg tgtccggcgg ctccgtgtcc tccggcgact actactggac ctggatccgg      120

cagtcccccg gcaagggcct ggagtggatc ggccacatct actactccgg caacaccaac      180

tacaacccct ccctgaagtc ccggctgacc atctccatcg acacctccaa gacccagttc      240

tccctgaagc tgtcctccgt gaccgccgcc gacaccgcca tctactactg cgtgcgggac      300

cgggtgaccg gcgccttcga catctggggc cagggcacca tggtgaccgt gtcctccggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtccc cctcctccct gtccgcctcc gtgggcgacc gggtgaccat cacctgccag      480

gcctcccagg acatctccaa ctacctgaac tggtaccagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc ctccaacctg gagaccggcg tgccctcccg gttctccggc      600

tccggctccg gcaccgactt caccttcacc atctcctccc tgcagcccga ggacatcgcc      660

acctacttct gccagcactt cgaccacctg cccctggcct tcggcggcgg caccaaggtg      720

gagatcaag                                                              729


<210>  148
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-489 EGFR scFv

<400>  148
caggtccagc tccaagagtc aggaccaggt ctggtcaaac cctcacagac gctctctctt       60

acttgcacag tatcaggcgg atccattagt tccggtgatt attactggtc ttggatccgc      120

cagcctcctg gtaaggggct ggagtggatc ggatacatat actacagtgg ttccactgat      180

tataatccgt cactcaagtc ccgagtaact atgtccgtgg atactagcaa aaatcagttc      240

agcctcaaag tcaattccgt aactgccgcc gacaccgcgg tctattattg tgcgcgggtg      300

agcatcttcg gcgtcggtac gttcgattac tggggacaag gaactctcgt aacagtaagc      360

tctggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgagatt      420

gtaatgaccc aaagccctgc cactctttct ctgtctccgg gggaacgagc gactctgtca      480

tgtagggcgt cccagagtgt ctctagctac ctcgcatggt atcagcagaa acccggacaa      540

gcccctcggc tcttgattta cgatgcctca aacagagcaa cggggattcc ggcacggttc      600

agcgggtctg gtagcgggac agacttcaca ctgacgatct cttcactcga accagaagat      660

tttgcagtct actattgcca tcagtatggt tctacgccac ttacatttgg cgggggcacc      720

aaggcggaga taaaa                                                       735


<210>  149
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VH CT489

<400>  149

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR VL CT489

<400>  150

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys 
            100                 105         


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H1

<400>  151

Ser Gly Asp Tyr Tyr Trp Ser 
1               5           


<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H2

<400>  152

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR H3

<400>  153

Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr 
1               5                   10      


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L1

<400>  154

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L2

<400>  155

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR antigen binding domain CDR L3

<400>  156

His Gln Tyr Gly Ser Thr Pro Leu Thr 
1               5                   


<210>  157
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  immunoreceptor tyrosine-based activation motif


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  Xaa is Leu or Ile

<400>  157

Tyr Xaa Xaa Xaa 
1               


<210>  158
<211>  195
<212>  PRT
<213>  Unknown

<220>
<223>  CAR intracellular domain

<400>  158

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                85                  90                  95      


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            100                 105                 110         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        115                 120                 125             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    130                 135                 140                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
145                 150                 155                 160 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                165                 170                 175     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            180                 185                 190         


Pro Pro Arg 
        195 


<210>  159
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  4-1BB co-stimulatory domain

<400>  159

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  160
<211>  126
<212>  DNA
<213>  Unknown

<220>
<223>  4-1BB co-stimulatory domain

<400>  160
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag gccagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  161
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-001765 PA2.1 scFv (mouse)

<400>  161
gatgttctga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga agccaggcca gtctccaaag ctgctcatct acaaagtttc caaccgattt      180

tctggggtcc cagacagatt tagcggatct ggctctggga ccgatttcac actcaagatc      240

agtagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cggacgtccg gtggaggcac aaagctggaa atcaagggag gtggcggctc tggaggcgga      360

ggtagcggag gtggaggctc tggtggccag gtccagctgc agcagtctgg acctgagctg      420

gtgaagccag gggcttcagt gaggatatcc tgtaaggcct ctggctacac ctttacaagt      480

taccatatac attgggtgaa gcagaggcct ggacagggac tcgaatggat tggatggatt      540

tatcctggaa atgttaatac tgagtacaat gagaagttca agggcaaggc cacactgact      600

gcagacaaat cgtccagcac agcctacatg cacctcagca gcctgacctc tgaggactct      660

gcggtctatt tctgtgccag agaggagatt acctatgcta tggattattg gggtcaagga      720

acctcagtca ccgtgtcctc a                                                741


<210>  162
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002159 PA2.1.8 scFv (humanized)

<400>  162
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat tgtattgacc      420

cagagcccag gcaccctgag cctctctcca ggagagcggg ccaccctcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtcaagccc caagattgct catctacaaa gtctctaaca gatttagtgg tattccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctccag gctcgagcca      660

gaagatttcg ccgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  163
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002160 PA2.1.9 scFv (humanized)

<400>  163
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tgtaatgacc      420

cagaccccac tcagcctgcc cgtcactcca ggagagccgg ccagcatcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatct gcagaaacca      540

ggtcaatccc cacaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctccag ggtcgaggca      660

gaagatgtcg gcgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  164
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002161 PA2.1.10 scFv (humanized)

<400>  164
gaggtgcagc tggtggagtc tgggggtggg ctggtgaagc ctgggggctc actgaggctt       60

tcctgcgcgg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggaaaag ggcttgagtg ggtgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcag attcaccatt agcagggacg attccaagaa cacactctac      240

ctgcagatga acagcctgaa aactgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccagcctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccaagc      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctcctc tctccagcca      660

gaagatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  165
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002162 PA2.1.14 scFv (humanized)

<400>  165
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggacg aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggaggt      360

ggcggctctg gaggcggagg tagcggaggt ggaggctctg gtggcgacat tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagcc      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  166
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002163 PA2.1.18 scFv (humanized)

<400>  166
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tgcattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatac atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccctt accgcggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt atttctgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacgt tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagctcc      480

agtcagagta ttgtacacag taatgggaac acctatatgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgtcatcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  167
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002164 BB7.2 scFv (mouse)

<400>  167
caggtgcagc tgcagcagtc tgggcctgag ctggtgaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggata caccttcact agctatcata tccagtgggt gaagcagagg      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggtag tacacagtat      180

aatgagaagt tcaagggcaa aaccaccctt accgcggaca aatcctccag cacagcctac      240

atgttgctga gcagcctgac ctctgaagac tctgctatct atttctgtgc gagggagggg      300

acctactacg ctatggacta ctggggccag ggaacctcag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tttgatgacc      420

cagactccac tctccctgcc tgtctctctt ggagaccaag tctccatctc ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttag aatggtatct gcagaaacca      540

ggtcagtctc caaagttgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctcgag agtggaggct      660

gaggatctgg gagtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtgga      720

ggtactaaac tggaaatcaa a                                                741


<210>  168
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002165 BB7.2.1 scFv (humanized)

<400>  168
cagctgcagc tgcaggagtc tgggcccggg ctggtgaagc cttcggaaac gctgagcctc       60

acctgcacgg tttctggata caccttcacc agctatcata tccagtggat ccgacagccc      120

cctggaaaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agccacgatt agcgtggaca catccaagaa ccaattctcc      240

ctgaacctgg acagcgtgag tgctgcggac acggccattt attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggcaaa gggagcacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccaa gctccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccttca cgattagcag cttgcagccc      660

gaagacatcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggccg      720

ggcacgaaag tggatattaa g                                                741


<210>  169
<211>  3217
<212>  DNA
<213>  Homo sapiens

<400>  169
atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggctct ggccctgacc       60

cagacctggg cgggtgagtg cggggtcggg agggaaacgg cctctgtggg gagaagcaac      120

gggcccgcct ggcgggggcg caggacccgg gaagccgcgc cgggaggagg gtcgggcggg      180

tctcagccac tcctcgtccc caggctctca ctccatgagg tatttcttca catccgtgtc      240

ccggcccggc cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt      300

cgtgcggttc gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga      360

gcaggagggt ccggagtatt gggacgggga gacacggaaa gtgaaggccc actcacagac      420

tcaccgagtg gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggtgagtg      480

accccggccc ggggcgcagg tcacgacctc tcatccccca cggacgggcc aggtcgccca      540

cagtctccgg gtccgagatc cgccccgaag ccgcgggacc ccgagaccct tgccccggga      600

gaggcccagg cgcctttacc cggtttcatt ttcagtttag gccaaaaatc cccccaggtt      660

ggtcggggcg gggcggggct cgggggaccg ggctgaccgc ggggtccggg ccaggttctc      720

acaccgtcca gaggatgtat ggctgcgacg tggggtcgga ctggcgcttc ctccgcgggt      780

accaccagta cgcctacgac ggcaaggatt acatcgccct gaaagaggac ctgcgctctt      840

tgaccgcggc ggacatggca gctcagacca ccaagcacaa gtgggaggcg gcccatgtgg      900

cggagcagtt gagagcctac ctggagggca cgtgcgtgga gtggctccgc agatacctgg      960

agaacgggaa ggagacgctg cagcgcacgg gtaccagggg ccacggggcg cctccctgat     1020

cgcctgtaga tctcccgggc tggcctccca caaggagggg agacaattgg gaccaacact     1080

agaatatcgc cctccctctg gtcctgaggg agaggaatcc tcctgggttt ccagatcctg     1140

taccagagag tgactctgag gttccgccct gctctctgac acaattaagg gataaaatct     1200

ctgaaggaat gacgggaaga cgatccctcg aatactgatg agtggttccc tttgacacac     1260

acaggcagca gccttgggcc cgtgactttt cctctcaggc cttgttctct gcttcacact     1320

caatgtgtgt gggggtctga gtccagcact tctgagtcct tcagcctcca ctcaggtcag     1380

gaccagaagt cgctgttccc tcttcaggga ctagaatttt ccacggaata ggagattatc     1440

ccaggtgcct gtgtccaggc tggtgtctgg gttctgtgct cccttcccca tcccaggtgt     1500

cctgtccatt ctcaagatag ccacatgtgt gctggaggag tgtcccatga cagatgcaaa     1560

atgcctgaat gatctgactc ttcctgacag acgcccccaa aacgcatatg actcaccacg     1620

ctgtctctga ccatgaagcc accctgaggt gctgggccct gagcttctac cctgcggaga     1680

tcacactgac ctggcagcgg gatggggagg accagaccca ggacacggag ctcgtggaga     1740

ccaggcctgc aggggatgga accttccaga agtgggcggc tgtggtggtg ccttctggac     1800

aggagcagag atacacctgc catgtgcagc atgagggttt gcccaagccc ctcaccctga     1860

gatggggtaa ggagggagac gggggtgtca tgtcttttag ggaaagcagg agcctctctg     1920

acctttagca gggtcagggc ccctcacctt cccctctttt cccagagccg tcttcccagc     1980

ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct gtgatcactg     2040

gagctgtggt cgctgctgtg atgtggagga ggaagagctc aggtggggaa ggggtgaagg     2100

gtgggtctga gatttcttgt ctcactgagg gttccaagac ccaggtagaa gtgtgccctg     2160

cctcgttact gggaagcacc acccacaatt atgggcctac ccagcctggg ccctgtgtgc     2220

cagcacttac tcttttgtaa agcacctgtt aaaatgaagg acagatttat caccttgatt     2280

acagcggtga tgggacctga tcccagcagt cacaagtcac aggggaaggt ccctgaggac     2340

cttcaggagg gcggttggtc caggacccac acctgctttc ttcatgtttc ctgatcccgc     2400

cctgggtctg cagtcacaca tttctggaaa cttctctgag gtccaagact tggaggttcc     2460

tctaggacct taaggccctg actcctttct ggtatctcac aggacatttt cttcccacag     2520

atagaaaagg agggagctac tctcaggctg caagtaagta tgaaggaggc tgatgcctga     2580

ggtccttggg atattgtgtt tgggagccca tgggggagct cacccacccc acaattcctc     2640

ctctagccac atcttctgtg ggatctgacc aggttctgtt tttgttctac cccaggcagt     2700

gacagtgccc agggctctga tgtgtctctc acagcttgta aaggtgagag cctggagggc     2760

ctgatgtgtg ttgggtgttg ggcggaacag tggacacagc tgtgctatgg ggtttctttc     2820

cattggatgt attgagcatg cgatgggctg tttaaagtgt gacccctcac tgtgacagat     2880

acgaatttgt tcatgaatat ttttttctat agtgtgagac agctgccttg tgtgggactg     2940

agaggcaaga gttgttcctg cccttccctt tgtgacttga agaaccctga ctttgtttct     3000

gcaaaggcac ctgcatgtgt ctgtgttcgt gtaggcataa tgtgaggagg tggggagacc     3060

accccacccc catgtccacc atgaccctct tcccacgctg acctgtgctc cctccccaat     3120

catctttcct gttccagaga ggtggggctg aggtgtctcc atctctgtct caacttcatg     3180

gtgcactgag ctgtaacttc ttccttccct attaaaa                              3217


<210>  170
<211>  6654
<212>  DNA
<213>  Homo sapiens

<400>  170
aagtggaggc gtcgcgctgg cgggcattcc tgaagctgac agcattcggg ccgagatgtc       60

tcgctccgtg gccttagctg tgctcgcgct actctctctt tctggcctgg aggctatcca      120

gcgtgagtct ctcctaccct cccgctctgg tccttcctct cccgctctgc accctctgtg      180

gccctcgctg tgctctctcg ctccgtgact tcccttctcc aagttctcct tggtggcccg      240

ccgtggggct agtccagggc tggatctcgg ggaagcggcg gggtggcctg ggagtgggga      300

agggggtgcg cacccgggac gcgcgctact tgcccctttc ggcggggagc aggggagacc      360

tttggcctac ggcgacggga gggtcgggac aaagtttagg gcgtcgataa gcgtcagagc      420

gccgaggttg ggggagggtt tctcttccgc tctttcgcgg ggcctctggc tcccccagcg      480

cagctggagt gggggacggg taggctcgtc ccaaaggcgc ggcgctgagg tttgtgaacg      540

cgtggagggg cgcttggggt ctgggggagg cgtcgcccgg gtaagcctgt ctgctgcggc      600

tctgcttccc ttagactgga gagctgtgga cttcgtctag gcgcccgcta agttcgcatg      660

tcctagcacc tctgggtcta tgtggggcca caccgtgggg aggaaacagc acgcgacgtt      720

tgtagaatgc ttggctgtga tacaaagcgg tttcgaataa ttaacttatt tgttcccatc      780

acatgtcact tttaaaaaat tataagaact acccgttatt gacatctttc tgtgtgccaa      840

ggactttatg tgctttgcgt catttaattt tgaaaacagt tatcttccgc catagataac      900

tactatggtt atcttctgcc tctcacagat gaagaaacta aggcaccgag attttaagaa      960

acttaattac acaggggata aatggcagca atcgagattg aagtcaagcc taaccagggc     1020

ttttgcggga gcgcatgcct tttggctgta attcgtgcat ttttttttaa gaaaaacgcc     1080

tgccttctgc gtgagattct ccagagcaaa ctgggcggca tgggccctgt ggtcttttcg     1140

tacagagggc ttcctctttg gctctttgcc tggttgtttc caagatgtac tgtgcctctt     1200

actttcggtt ttgaaaacat gagggggttg ggcgtggtag cttacgcctg taatcccagc     1260

acttagggag gccgaggcgg gaggatggct tgaggtccgt agttgagacc agcctggcca     1320

acatggtgaa gcctggtctc tacaaaaaat aataacaaaa attagccggg tgtggtggct     1380

cgtgcctgtg gtcccagctg ctccggtggc tgaggcggga ggatctcttg agcttaggct     1440

tttgagctat catggcgcca gtgcactcca gcgtgggcaa cagagcgaga ccctgtctct     1500

caaaaaagaa aaaaaaaaaa aaagaaagag aaaagaaaag aaagaaagaa gtgaaggttt     1560

gtcagtcagg ggagctgtaa aaccattaat aaagataatc caagatggtt accaagactg     1620

ttgaggacgc cagagatctt gagcactttc taagtacctg gcaatacact aagcgcgctc     1680

accttttcct ctggcaaaac atgatcgaaa gcagaatgtt ttgatcatga gaaaattgca     1740

tttaatttga atacaattta tttacaacat aaaggataat gtatatatca ccaccattac     1800

tggtatttgc tggttatgtt agatgtcatt ttaaaaaata acaatctgat atttaaaaaa     1860

aaatcttatt ttgaaaattt ccaaagtaat acatgccatg catagaccat ttctggaaga     1920

taccacaaga aacatgtaat gatgattgcc tctgaaggtc tattttcctc ctctgacctg     1980

tgtgtgggtt ttgtttttgt tttactgtgg gcataaatta atttttcagt taagttttgg     2040

aagcttaaat aactctccaa aagtcataaa gccagtaact ggttgagccc aaattcaaac     2100

ccagcctgtc tgatacttgt cctcttctta gaaaagatta cagtgatgct ctcacaaaat     2160

cttgccgcct tccctcaaac agagagttcc aggcaggatg aatctgtgct ctgatccctg     2220

aggcatttaa tatgttctta ttattagaag ctcagatgca aagagctctc ttagctttta     2280

atgttatgaa aaaaatcagg tcttcattag attccccaat ccacctcttg atggggctag     2340

tagcctttcc ttaatgatag ggtgtttcta gagagatata tctggtcaag gtggcctggt     2400

actcctcctt ctccccacag cctcccagac aaggaggagt agctgccttt tagtgatcat     2460

gtaccctgaa tataagtgta tttaaaagaa ttttatacac atatatttag tgtcaatctg     2520

tatatttagt agcactaaca cttctcttca ttttcaatga aaaatataga gtttataata     2580

ttttcttccc acttccccat ggatggtcta gtcatgcctc tcattttgga aagtactgtt     2640

tctgaaacat taggcaatat attcccaacc tggctagttt acagcaatca cctgtggatg     2700

ctaattaaaa cgcaaatccc actgtcacat gcattactcc atttgatcat aatggaaagt     2760

atgttctgtc ccatttgcca tagtcctcac ctatccctgt tgtattttat cgggtccaac     2820

tcaaccattt aaggtatttg ccagctcttg tatgcattta ggttttgttt ctttgttttt     2880

tagctcatga aattaggtac aaagtcagag aggggtctgg catataaaac ctcagcagaa     2940

ataaagaggt tttgttgttt ggtaagaaca taccttgggt tggttgggca cggtggctcg     3000

tgcctgtaat cccaacactt tgggaggcca aggcaggctg atcacttgaa gttgggagtt     3060

caagaccagc ctggccaaca tggtgaaatc ccgtctctac tgaaaataca aaaattaacc     3120

aggcatggtg gtgtgtgcct gtagtcccag gaatcacttg aacccaggag gcggaggttg     3180

cagtgagctg agatctcacc actgcacact gcactccagc ctgggcaatg gaatgagatt     3240

ccatcccaaa aaataaaaaa ataaaaaaat aaagaacata ccttgggttg atccacttag     3300

gaacctcaga taataacatc tgccacgtat agagcaattg ctatgtccca ggcactctac     3360

tagacacttc atacagttta gaaaatcaga tgggtgtaga tcaaggcagg agcaggaacc     3420

aaaaagaaag gcataaacat aagaaaaaaa atggaagggg tggaaacaga gtacaataac     3480

atgagtaatt tgatgggggc tattatgaac tgagaaatga actttgaaaa gtatcttggg     3540

gccaaatcat gtagactctt gagtgatgtg ttaaggaatg ctatgagtgc tgagagggca     3600

tcagaagtcc ttgagagcct ccagagaaag gctcttaaaa atgcagcgca atctccagtg     3660

acagaagata ctgctagaaa tctgctagaa aaaaaacaaa aaaggcatgt atagaggaat     3720

tatgagggaa agataccaag tcacggttta ttcttcaaaa tggaggtggc ttgttgggaa     3780

ggtggaagct catttggcca gagtggaaat ggaattggga gaaatcgatg accaaatgta     3840

aacacttggt gcctgatata gcttgacacc aagttagccc caagtgaaat accctggcaa     3900

tattaatgtg tcttttcccg atattcctca ggtactccaa agattcaggt ttactcacgt     3960

catccagcag agaatggaaa gtcaaatttc ctgaattgct atgtgtctgg gtttcatcca     4020

tccgacattg aagttgactt actgaagaat ggagagagaa ttgaaaaagt ggagcattca     4080

gacttgtctt tcagcaagga ctggtctttc tatctcttgt actacactga attcaccccc     4140

actgaaaaag atgagtatgc ctgccgtgtg aaccatgtga ctttgtcaca gcccaagata     4200

gttaagtggg gtaagtctta cattcttttg taagctgctg aaagttgtgt atgagtagtc     4260

atatcataaa gctgctttga tataaaaaag gtctatggcc atactaccct gaatgagtcc     4320

catcccatct gatataaaca atctgcatat tgggattgtc agggaatgtt cttaaagatc     4380

agattagtgg cacctgctga gatactgatg cacagcatgg tttctgaacc agtagtttcc     4440

ctgcagttga gcagggagca gcagcagcac ttgcacaaat acatatacac tcttaacact     4500

tcttacctac tggcttcctc tagcttttgt ggcagcttca ggtatattta gcactgaacg     4560

aacatctcaa gaaggtatag gcctttgttt gtaagtcctg ctgtcctagc atcctataat     4620

cctggacttc tccagtactt tctggctgga ttggtatctg aggctagtag gaagggcttg     4680

ttcctgctgg gtagctctaa acaatgtatt catgggtagg aacagcagcc tattctgcca     4740

gccttatttc taaccatttt agacatttgt tagtacatgg tattttaaaa gtaaaactta     4800

atgtcttcct tttttttctc cactgtcttt ttcatagatc gagacatgta agcagcatca     4860

tggaggtaag tttttgacct tgagaaaatg tttttgtttc actgtcctga ggactattta     4920

tagacagctc taacatgata accctcacta tgtggagaac attgacagag taacatttta     4980

gcagggaaag aagaatccta cagggtcatg ttcccttctc ctgtggagtg gcatgaagaa     5040

ggtgtatggc cccaggtatg gccatattac tgaccctcta cagagagggc aaaggaactg     5100

ccagtatggt attgcaggat aaaggcaggt ggttacccac attacctgca aggctttgat     5160

ctttcttctg ccatttccac attggacatc tctgctgagg agagaaaatg aaccactctt     5220

ttcctttgta taatgttgtt ttattcttca gacagaagag aggagttata cagctctgca     5280

gacatcccat tcctgtatgg ggactgtgtt tgcctcttag aggttcccag gccactagag     5340

gagataaagg gaaacagatt gttataactt gatataatga tactataata gatgtaacta     5400

caaggagctc cagaagcaag agagagggag gaacttggac ttctctgcat ctttagttgg     5460

agtccaaagg cttttcaatg aaattctact gcccagggta cattgatgct gaaaccccat     5520

tcaaatctcc tgttatattc tagaacaggg aattgatttg ggagagcatc aggaaggtgg     5580

atgatctgcc cagtcacact gttagtaaat tgtagagcca ggacctgaac tctaatatag     5640

tcatgtgtta cttaatgacg gggacatgtt ctgagaaatg cttacacaaa cctaggtgtt     5700

gtagcctact acacgcatag gctacatggt atagcctatt gctcctagac tacaaacctg     5760

tacagcctgt tactgtactg aatactgtgg gcagttgtaa cacaatggta agtatttgtg     5820

tatctaaaca tagaagttgc agtaaaaata tgctatttta atcttatgag accactgtca     5880

tatatacagt ccatcattga ccaaaacatc atatcagcat tttttcttct aagattttgg     5940

gagcaccaaa gggatacact aacaggatat actctttata atgggtttgg agaactgtct     6000

gcagctactt cttttaaaaa ggtgatctac acagtagaaa ttagacaagt ttggtaatga     6060

gatctgcaat ccaaataaaa taaattcatt gctaaccttt ttcttttctt ttcaggtttg     6120

aagatgccgc atttggattg gatgaattcc aaattctgct tgcttgcttt ttaatattga     6180

tatgcttata cacttacact ttatgcacaa aatgtagggt tataataatg ttaacatgga     6240

catgatcttc tttataattc tactttgagt gctgtctcca tgtttgatgt atctgagcag     6300

gttgctccac aggtagctct aggagggctg gcaacttaga ggtggggagc agagaattct     6360

cttatccaac atcaacatct tggtcagatt tgaactcttc aatctcttgc actcaaagct     6420

tgttaagata gttaagcgtg cataagttaa cttccaattt acatactctg cttagaattt     6480

gggggaaaat ttagaaatat aattgacagg attattggaa atttgttata atgaatgaaa     6540

cattttgtca tataagattc atatttactt cttatacatt tgataaagta aggcatggtt     6600

gtggttaatc tggtttattt ttgttccaca agttaaataa atcataaaac ttga           6654


<210>  171
<211>  1698
<212>  DNA
<213>  Homo sapiens

<400>  171
cagaagcaga ggggtcaggg cgaagtccca gggccccagg cgtggctctc agggtctcag       60

gccccgaagg cggtgtatgg attggggagt cccagccttg gggattcccc aactccgcag      120

tttcttttct ccctctccca acctatgtag ggtccttctt cctggatact cacgacgcgg      180

acccagttct cactcccatt gggtgtcggg tttccagaga agccaatcag tgtcgtcgcg      240

gtcgcggttc taaagtccgc acgcacccac cgggactcag attctcccca gacgccgagg      300

atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggctct ggccctgacc      360

cagacctggg cgggctctca ctccatgagg tatttcttca catccgtgtc ccggcccggc      420

cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcggttc      480

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggt      540

ccggagtatt gggacgggga gacacggaaa gtgaaggccc actcacagac tcaccgagtg      600

gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggttctca caccgtccag      660

aggatgtatg gctgcgacgt ggggtcggac tggcgcttcc tccgcgggta ccaccagtac      720

gcctacgacg gcaaggatta catcgccctg aaagaggacc tgcgctcttg gaccgcggcg      780

gacatggcag ctcagaccac caagcacaag tgggaggcgg cccatgtggc ggagcagttg      840

agagcctacc tggagggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag      900

gagacgctgc agcgcacgga cgcccccaaa acgcatatga ctcaccacgc tgtctctgac      960

catgaagcca ccctgaggtg ctgggccctg agcttctacc ctgcggagat cacactgacc     1020

tggcagcggg atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca     1080

ggggatggaa ccttccagaa gtgggcggct gtggtggtgc cttctggaca ggagcagaga     1140

tacacctgcc atgtgcagca tgagggtttg cccaagcccc tcaccctgag atgggagccg     1200

tcttcccagc ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct     1260

gtgatcactg gagctgtggt cgctgctgtg atgtggagga ggaagagctc agatagaaaa     1320

ggagggagct actctcaggc tgcaagcagt gacagtgccc agggctctga tgtgtctctc     1380

acagcttgta aagtgtgaga cagctgcctt gtgtgggact gagaggcaag agttgttcct     1440

gcccttccct ttgtgacttg aagaaccctg actttgtttc tgcaaaggca cctgcatgtg     1500

tctgtgttcg tgtaggcata atgtgaggag gtggggagac caccccaccc ccatgtccac     1560

catgaccctc ttcccacgct gacctgtgct ccctccccaa tcatctttcc tgttccagag     1620

aggtggggct gaggtgtctc catctctgtc tcaacttcat ggtgcactga gctgtaactt     1680

cttccttccc tattaaaa                                                   1698


<210>  172
<211>  943
<212>  RNA
<213>  Homo sapiens

<400>  172
auuccugaag cugacagcau ucgggccgag augucucgcu ccguggccuu agcugugcuc       60

gcgcuacucu cucuuucugg ccuggaggcu auccagcgua cuccaaagau ucagguuuac      120

ucacgucauc cagcagagaa uggaaaguca aauuuccuga auugcuaugu gucuggguuu      180

cauccauccg acauugaagu ugacuuacug aagaauggag agagaauuga aaaaguggag      240

cauucagacu ugucuuucag caaggacugg ucuuucuauc ucuuguacua cacugaauuc      300

acccccacug aaaaagauga guaugccugc cgugugaacc augugacuuu gucacagccc      360

aagauaguua agugggaucg agacauguaa gcagcaucau ggagguuuga agaugccgca      420

uuuggauugg augaauucca aauucugcuu gcuugcuuuu uaauauugau augcuuauac      480

acuuacacuu uaugcacaaa auguaggguu auaauaaugu uaacauggac augaucuucu      540

uuauaauucu acuuugagug cugucuccau guuugaugua ucugagcagg uugcuccaca      600

gguagcucua ggagggcugg caacuuagag guggggagca gagaauucuc uuauccaaca      660

ucaacaucuu ggucagauuu gaacucuuca aucucuugca cucaaagcuu guuaagauag      720

uuaagcgugc auaaguuaac uuccaauuua cauacucugc uuagaauuug ggggaaaauu      780

uagaaauaua auugacagga uuauuggaaa uuuguuauaa ugaaugaaac auuuugucau      840

auaagauuca uauuuacuuc uuauacauuu gauaaaguaa ggcaugguug ugguuaaucu      900

gguuuauuuu uguuccacaa guuaaauaaa ucauaaaacu uga                        943


<210>  173
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1765 (anti-HLA-A*02 chimeric antigen receptor) Prot

<400>  173

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Ser Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn 
        195                 200                 205             


Thr Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
        515                 520         


<210>  174
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2162 (anti-HLA-A*02 chimeric antigen receptor) Protein

<400>  174

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr 
65                  70                  75                  80  


Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser His Val 
                245                 250                 255     


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
        515                 520         


<210>  175
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT486 (anti-EGFR chimeric antigen receptor) Protein

<400>  175

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Lys Gln Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 
65                  70                  75                  80  


Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr 
            100                 105                 110         


Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
145                 150                 155                 160 


Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg 
                165                 170                 175     


Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
            180                 185                 190         


Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr 
        195                 200                 205             


Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp 
225                 230                 235                 240 


Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe 
                245                 250                 255     


Gly Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  176
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT488 (anti-EGFR chimeric antigen receptor) Prot

<400>  176

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn 
65                  70                  75                  80  


Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp 
                85                  90                  95      


Thr Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
        195                 200                 205             


Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  177
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT489 (anti-EGFR chimeric antigen receptor) Prot

<400>  177

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Val Asn Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Ser Ile Phe Gly Val Gly 
        115                 120                 125             


Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                165                 170                 175     


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg 
    370                 375                 380                 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
385                 390                 395                 400 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
                405                 410                 415     


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            420                 425                 430         


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        435                 440                 445             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    450                 455                 460                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
465                 470                 475                 480 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                485                 490                 495     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            500                 505                 510         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        515                 520                 525             


Gln Ala Leu Pro Pro Arg 
    530                 


<210>  178
<211>  21
<212>  PRT
<213>  Unknown

<220>
<223>  T2A self-cleaving peptide

<400>  178

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  179
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA0089

<400>  179
gcactcaaag cttgttaaga tcgaaatctt aacaagcttt gagtgc                      46


<210>  180
<211>  1600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT486 (anti-EGFR chimeric antigen receptor) DNA

<400>  180
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctgaa gcagtccggc cccggcctgg tgcagccctc ccagtccctg      120

tccatcacct gcaccgtgtc cggcttctcc ctgaccaact acggcgtgca ctgggtgcgg      180

cagtcccccg gcaagggcct ggagtggctg ggcgtgatct ggtccggcgg caacaccgac      240

tacaacaccc ccttcacctc ccggctgtcc atcaacaagg acaactccaa gtcccaggtg      300

ttcttcaaga tgaactccct gcagtccaac gacaccgcca tctactactg cgcccgggcc      360

ctgacctact acgactacga gttcgcctac tggggccagg gcaccctggt gaccgtgtcc      420

gccggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      480

ctgctgaccc agtcccccgt gatcctgtcc gtgtcccccg gcgagcgggt gtccttctcc      540

tgccgggcct cccagtccat cggcaccaac atccactggt accagcagcg gaccaacggc      600

tccccccggc tgctgatcaa gtacgcctcc gagtccatct ccggcatccc ctcccggttc      660

tccggctccg gctccggcac cgacttcacc ctgtccatca actccgtgga gtccgaggac      720

atcgccgact actactgcca gcagaacaac aactggccca ccaccttcgg cgccggcacc      780

aagctggagc tgaagaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat ttctgggtgc tggtcgttgt gggcggcgtg      960

ctggcctgct acagcctgct ggtgacagtg gccttcatca tcttttgggt gaggagcaag     1020

cggagcagac tgctgcacag cgactacatg aacatgaccc cccggaggcc tggccccacc     1080

cggaagcact accagcccta cgcccctccc agggatttcg ccgcctaccg gagcaaacgg     1140

ggcagaaaga aactcctgta tatattcaaa caaccattta tgaggccagt acaaactact     1200

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1260

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1320

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc     1380

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1440

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1500

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc     1560

tacgacgccc ttcacatgca ggccctgccc cctcgctagc                           1600


<210>  181
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2162 (anti-HLA-A*02 chimeric antigen receptor) DNA

<400>  181
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg gtcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactagct atcatataca ttgggtgcgc      180

caggcccccg gacaagggct tgaatggatt ggctggatct accctggcaa tgttaacaca      240

gaatataatg agaagttcaa gggcaaagcc accattaccg cggacgaatc cacgaacaca      300

gcctacatgg agctgagcag cctgagatct gaagacacgg ctgtgtatta ctgtgcgagg      360

gaggaaatta cctacgctat ggactactgg ggccagggaa ccctggtcac cgtgtcctca      420

ggaggtggcg gctctggagg cggaggtagc ggaggtggag gctctggtgg cgacattcaa      480

atgacccaga gcccatccac cctgagcgca tctgtaggtg accgggtcac catcacttgt      540

agatccagtc agagtattgt acacagtaat gggaacacct atttggaatg gtaccagcag      600

aagccaggta aagccccaaa attgctcatc tacaaagtct ctaacagatt tagtggtgta      660

ccagccaggt tcagcggttc cggaagtggt actgaattca ccctcacgat ctcctctctc      720

cagccagatg atttcgccac ttattactgt tttcaaggtt cacatgtgcc gcgcacattc      780

ggtcagggta ctaaagtaga agtcaaatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccta gtgatcctct ggagctcgtg gtctcaggac cgtctggagg cccaagctct      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac acccaccggg      960

tcggatcctc agagtggtct gggaagacac ctgggagttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctgctcctg ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggat     1260

actcggagcc cacacgatga agatccacag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagaa gggaaatggc ctctcctcct tccccactgt ctggagagtt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagct     1440

cctcaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccac                                                                1566


<210>  182
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT488 (anti-EGFR chimeric antigen receptor) DNA

<400>  182
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tgcagctgca ggagtccggc cccggcctgg tgaagccctc cgagaccctg      120

tccctgacct gcaccgtgtc cggcggctcc gtgtcctccg gcgactacta ctggacctgg      180

atccggcagt cccccggcaa gggcctggag tggatcggcc acatctacta ctccggcaac      240

accaactaca acccctccct gaagtcccgg ctgaccatct ccatcgacac ctccaagacc      300

cagttctccc tgaagctgtc ctccgtgacc gccgccgaca ccgccatcta ctactgcgtg      360

cgggaccggg tgaccggcgc cttcgacatc tggggccagg gcaccatggt gaccgtgtcc      420

tccggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      480

cagatgaccc agtccccctc ctccctgtcc gcctccgtgg gcgaccgggt gaccatcacc      540

tgccaggcct cccaggacat ctccaactac ctgaactggt accagcagaa gcccggcaag      600

gcccccaagc tgctgatcta cgacgcctcc aacctggaga ccggcgtgcc ctcccggttc      660

tccggctccg gctccggcac cgacttcacc ttcaccatct cctccctgca gcccgaggac      720

atcgccacct acttctgcca gcacttcgac cacctgcccc tggccttcgg cggcggcacc      780

aaggtggaga tcaagaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc      840

gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg      900

cacacgaggg ggctggactt cgcctgtgat ttctgggtgc tggtcgttgt gggcggcgtg      960

ctggcctgct acagcctgct ggtgacagtg gccttcatca tcttttgggt gaggagcaag     1020

cggagcagac tgctgcacag cgactacatg aacatgaccc cccggaggcc tggccccacc     1080

cggaagcact accagcccta cgcccctccc agggatttcg ccgcctaccg gagcaaacgg     1140

ggcagaaaga aactcctgta tatattcaaa caaccattta tgaggccagt acaaactact     1200

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1260

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1320

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc     1380

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1440

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1500

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc     1560

tacgacgccc ttcacatgca ggccctgccc cctcgctag                            1599


<210>  183
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1765 (anti-HLA-A*02 chimeric antigen receptor) DNA

<400>  183
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtgatg ttttgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc attgtacata gtaatggaaa cacctattta      180

gaatggtacc tgcagaaacc aggccagtct ccaaagctcc tgatctacaa agtttccaac      240

cgattttctg gggtcccaga caggttcagt ggcagtggat cagggacaga tttcacactc      300

aagatcagta gagtggaggc tgaggatctg ggagtttatt actgctttca aggttcacat      360

gttcctcgga cgtccggtgg aggcaccaag ctggaaatca aaggcggagg tggaagcgga      420

gggggaggat ctggcggcgg aggaagcgga ggccaggtcc agctgcagca gtctggacct      480

gagctggtga agcctggggc ttcagtgagg atatcctgca aggcttctgg ctacaccttc      540

acaagttacc atatacattg ggtgaagcag aggcctggac agggacttga gtggattgga      600

tggatttatc ctggaaatgt taatactgag tacaatgaga agttcaaggg caaggccaca      660

ctgactgcag acaaatcgtc cagcacagcc tacatgcacc tcagcagcct gacctctgag      720

gactctgcgg tctatttctg tgccagagag gagattacct atgctatgga ctactggggt      780

caaggaacct cagtcaccgt gtcctcatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccca gtgaccccct ggagctcgtg gtctcaggac cgtctggggg ccccagctcc      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac ccccaccggg      960

tcggatcccc agagtggtct gggaaggcac ctgggggttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctcctcctc ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggac     1260

actcggagcc cacacgatga agacccccag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagga gagaaatggc ctctcctcct tccccactgt ctggggaatt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagcc     1440

ccccaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccactag                                                             1569


<210>  184
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT489 (anti-EGFR chimeric antigen receptor) DNA

<400>  184
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtcagg tccagctcca agagtcagga ccaggtctgg tcaaaccctc acagacgctc      120

tctcttactt gcacagtatc aggcggatcc attagttccg gtgattatta ctggtcttgg      180

atccgccagc ctcctggtaa ggggctggag tggatcggat acatatacta cagtggttcc      240

actgattata atccgtcact caagtcccga gtaactatgt ccgtggatac tagcaaaaat      300

cagttcagcc tcaaagtcaa ttccgtaact gccgccgaca ccgcggtcta ttattgtgcg      360

cgggtgagca tcttcggcgt cggtacgttc gattactggg gacaaggaac tctcgtaaca      420

gtaagctctg gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      480

gagattgtaa tgacccaaag ccctgccact ctttctctgt ctccggggga acgagcgact      540

ctgtcatgta gggcgtccca gagtgtctct agctacctcg catggtatca gcagaaaccc      600

ggacaagccc ctcggctctt gatttacgat gcctcaaaca gagcaacggg gattccggca      660

cggttcagcg ggtctggtag cgggacagac ttcacactga cgatctcttc actcgaacca      720

gaagattttg cagtctacta ttgccatcag tatggttcta cgccacttac atttggcggg      780

ggcaccaagg cggagataaa aaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatttct gggtgctggt cgttgtgggc      960

ggcgtgctgg cctgctacag cctgctggtg acagtggcct tcatcatctt ttgggtgagg     1020

agcaagcgga gcagactgct gcacagcgac tacatgaaca tgaccccccg gaggcctggc     1080

cccacccgga agcactacca gccctacgcc cctcccaggg atttcgccgc ctaccggagc     1140

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag gccagtacaa     1200

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1260

gaactgagag tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac     1320

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagcgt     1380

agaggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg     1440

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1500

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gactcagtac agccaccaag     1560

gacacctacg acgcccttca catgcaggcc ctgccccctc gctag                     1605


<210>  185
<211>  3234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2162-T2A-CT489 DNA

<400>  185
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg gtcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactagct atcatataca ttgggtgcgc      180

caggcccccg gacaagggct tgaatggatt ggctggatct accctggcaa tgttaacaca      240

gaatataatg agaagttcaa gggcaaagcc accattaccg cggacgaatc cacgaacaca      300

gcctacatgg agctgagcag cctgagatct gaagacacgg ctgtgtatta ctgtgcgagg      360

gaggaaatta cctacgctat ggactactgg ggccagggaa ccctggtcac cgtgtcctca      420

ggaggtggcg gctctggagg cggaggtagc ggaggtggag gctctggtgg cgacattcaa      480

atgacccaga gcccatccac cctgagcgca tctgtaggtg accgggtcac catcacttgt      540

agatccagtc agagtattgt acacagtaat gggaacacct atttggaatg gtaccagcag      600

aagccaggta aagccccaaa attgctcatc tacaaagtct ctaacagatt tagtggtgta      660

ccagccaggt tcagcggttc cggaagtggt actgaattca ccctcacgat ctcctctctc      720

cagccagatg atttcgccac ttattactgt tttcaaggtt cacatgtgcc gcgcacattc      780

ggtcagggta ctaaagtaga agtcaaatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccta gtgatcctct ggagctcgtg gtctcaggac cgtctggagg cccaagctct      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac acccaccggg      960

tcggatcctc agagtggtct gggaagacac ctgggagttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctgctcctg ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggat     1260

actcggagcc cacacgatga agatccacag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagaa gggaaatggc ctctcctcct tccccactgt ctggagagtt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagct     1440

cctcaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccacggat ccggagaggg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac     1620

cctggcccca tggacatgag ggtccccgct cagctcctgg ggctcctgct actctggctc     1680

cgaggtgcca gatgtcaggt ccagctccaa gagtcaggac caggtctggt caaaccctca     1740

cagacgctct ctcttacttg cacagtatca ggcggatcca ttagttccgg tgattattac     1800

tggtcttgga tccgccagcc tcctggtaag gggctggagt ggatcggata catatactac     1860

agtggttcca ctgattataa tccgtcactc aagtcccgag taactatgtc cgtggatact     1920

agcaaaaatc agttcagcct caaagtcaat tccgtaactg ccgccgacac cgcggtctat     1980

tattgtgcgc gggtgagcat cttcggcgtc ggtacgttcg attactgggg acaaggaact     2040

ctcgtaacag taagctctgg cggaggtgga agcggagggg gaggatctgg cggcggagga     2100

agcggaggcg agattgtaat gacccaaagc cctgccactc tttctctgtc tccgggggaa     2160

cgagcgactc tgtcatgtag ggcgtcccag agtgtctcta gctacctcgc atggtatcag     2220

cagaaacccg gacaagcccc tcggctcttg atttacgatg cctcaaacag agcaacgggg     2280

attccggcac ggttcagcgg gtctggtagc gggacagact tcacactgac gatctcttca     2340

ctcgaaccag aagattttgc agtctactat tgccatcagt atggttctac gccacttaca     2400

tttggcgggg gcaccaaggc ggagataaaa accacgacgc cagcgccgcg accaccaaca     2460

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     2520

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatttctg ggtgctggtc     2580

gttgtgggcg gcgtgctggc ctgctacagc ctgctggtga cagtggcctt catcatcttt     2640

tgggtgagga gcaagcggag cagactgctg cacagcgact acatgaacat gaccccccgg     2700

aggcctggcc ccacccggaa gcactaccag ccctacgccc ctcccaggga tttcgccgcc     2760

taccggagca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgagg     2820

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     2880

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     2940

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     3000

gacaagcgta gaggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     3060

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     3120

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg actcagtaca     3180

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctag           3234


<210>  186
<211>  1077
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2162-T2A-CT489 Prot

<400>  186

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr 
65                  70                  75                  80  


Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser His Val 
                245                 250                 255     


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Gly Ser Gly Glu Gly Arg 
        515                 520                 525             


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu 
545                 550                 555                 560 


Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
                565                 570                 575     


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
            580                 585                 590         


Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro 
        595                 600                 605             


Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr 
    610                 615                 620                 


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr 
625                 630                 635                 640 


Ser Lys Asn Gln Phe Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp 
                645                 650                 655     


Thr Ala Val Tyr Tyr Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr 
            660                 665                 670         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        675                 680                 685             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu 
    690                 695                 700                 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
705                 710                 715                 720 


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
                725                 730                 735     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
            740                 745                 750         


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
        755                 760                 765             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
    770                 775                 780                 


Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu Thr 
785                 790                 795                 800 


Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys Thr Thr Thr Pro Ala Pro 
                805                 810                 815     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            820                 825                 830         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        835                 840                 845             


Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly 
    850                 855                 860                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
865                 870                 875                 880 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                885                 890                 895     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            900                 905                 910         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
        915                 920                 925             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    930                 935                 940                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
945                 950                 955                 960 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                965                 970                 975     


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            980                 985                 990         


Arg Arg Glu Glu Tyr Asp Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro 
        995                 1000                 1005             


Glu Met  Gly Gly Lys Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu 
    1010                 1015                 1020             


Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu 
    1025                 1030                 1035             


Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly 
    1040                 1045                 1050             


Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala 
    1055                 1060                 1065             


Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1070                 1075         


<210>  187
<211>  3234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1765-T2A-CT489 DNA

<400>  187
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgcgatg ttctgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc attgtacata gtaatggaaa cacctattta      180

gaatggtacc tgcagaagcc aggccagtct ccaaagctgc tcatctacaa agtttccaac      240

cgattttctg gggtcccaga cagatttagc ggatctggct ctgggaccga tttcacactc      300

aagatcagta gagtggaggc tgaggatctg ggagtttatt actgctttca aggttcacat      360

gttcctcgga cgtccggtgg aggcacaaag ctggaaatca agggaggtgg cggctctgga      420

ggcggaggta gcggaggtgg aggctctggt ggccaggtcc agctgcagca gtctggacct      480

gagctggtga agccaggggc ttcagtgagg atatcctgta aggcctctgg ctacaccttt      540

acaagttacc atatacattg ggtgaagcag aggcctggac agggactcga atggattgga      600

tggatttatc ctggaaatgt taatactgag tacaatgaga agttcaaggg caaggccaca      660

ctgactgcag acaaatcgtc cagcacagcc tacatgcacc tcagcagcct gacctctgag      720

gactctgcgg tctatttctg tgccagagag gagattacct atgctatgga ttattggggt      780

caaggaacct cagtcaccgt gtcctcatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccta gtgatcctct ggagctcgtg gtctcaggac cgtctggagg cccaagctct      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac acccaccggg      960

tcggatcctc agagtggtct gggaagacac ctgggagttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctgctcctg ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggat     1260

actcggagcc cacacgatga agatccacag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagaa gggaaatggc ctctcctcct tccccactgt ctggagagtt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagct     1440

cctcaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccacggat ccggagaggg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac     1620

cctggcccca tggacatgag ggtccccgct cagctcctgg ggctcctgct actctggctc     1680

cgaggtgcca gatgtcaggt ccagctccaa gagtcaggac caggtctggt caaaccctca     1740

cagacgctct ctcttacttg cacagtatca ggcggatcca ttagttccgg tgattattac     1800

tggtcttgga tccgccagcc tcctggtaag gggctggagt ggatcggata catatactac     1860

agtggttcca ctgattataa tccgtcactc aagtcccgag taactatgtc cgtggatact     1920

agcaaaaatc agttcagcct caaagtcaat tccgtaactg ccgccgacac cgcggtctat     1980

tattgtgcgc gggtgagcat cttcggcgtc ggtacgttcg attactgggg acaaggaact     2040

ctcgtaacag taagctctgg cggaggtgga agcggagggg gaggatctgg cggcggagga     2100

agcggaggcg agattgtaat gacccaaagc cctgccactc tttctctgtc tccgggggaa     2160

cgagcgactc tgtcatgtag ggcgtcccag agtgtctcta gctacctcgc atggtatcag     2220

cagaaacccg gacaagcccc tcggctcttg atttacgatg cctcaaacag agcaacgggg     2280

attccggcac ggttcagcgg gtctggtagc gggacagact tcacactgac gatctcttca     2340

ctcgaaccag aagattttgc agtctactat tgccatcagt atggttctac gccacttaca     2400

tttggcgggg gcaccaaggc ggagataaaa accacgacgc cagcgccgcg accaccaaca     2460

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg     2520

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatttctg ggtgctggtc     2580

gttgtgggcg gcgtgctggc ctgctacagc ctgctggtga cagtggcctt catcatcttt     2640

tgggtgagga gcaagcggag cagactgctg cacagcgact acatgaacat gaccccccgg     2700

aggcctggcc ccacccggaa gcactaccag ccctacgccc ctcccaggga tttcgccgcc     2760

taccggagca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgagg     2820

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     2880

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     2940

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     3000

gacaagcgta gaggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     3060

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     3120

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg actcagtaca     3180

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           3234


<210>  188
<211>  1077
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1765-T2A-CT489 Prot

<400>  188

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Ser Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn 
        195                 200                 205             


Thr Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Gly Ser Gly Glu Gly Arg 
        515                 520                 525             


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu 
545                 550                 555                 560 


Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
                565                 570                 575     


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
            580                 585                 590         


Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro 
        595                 600                 605             


Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr 
    610                 615                 620                 


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr 
625                 630                 635                 640 


Ser Lys Asn Gln Phe Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp 
                645                 650                 655     


Thr Ala Val Tyr Tyr Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr 
            660                 665                 670         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        675                 680                 685             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu 
    690                 695                 700                 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
705                 710                 715                 720 


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu 
                725                 730                 735     


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
            740                 745                 750         


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
        755                 760                 765             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
    770                 775                 780                 


Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu Thr 
785                 790                 795                 800 


Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys Thr Thr Thr Pro Ala Pro 
                805                 810                 815     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            820                 825                 830         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        835                 840                 845             


Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly 
    850                 855                 860                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
865                 870                 875                 880 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                885                 890                 895     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            900                 905                 910         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
        915                 920                 925             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    930                 935                 940                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
945                 950                 955                 960 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                965                 970                 975     


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            980                 985                 990         


Arg Arg Glu Glu Tyr Asp Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro 
        995                 1000                 1005             


Glu Met  Gly Gly Lys Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu 
    1010                 1015                 1020             


Tyr Asn  Glu Leu Gln Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu 
    1025                 1030                 1035             


Ile Gly  Met Lys Gly Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly 
    1040                 1045                 1050             


Leu Tyr  Gln Gly Leu Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala 
    1055                 1060                 1065             


Leu His  Met Gln Ala Leu Pro  Pro Arg 
    1070                 1075         


<210>  189
<211>  3228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1765-T2A-CT486 DNA

<400>  189
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgcgatg ttctgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc attgtacata gtaatggaaa cacctattta      180

gaatggtacc tgcagaagcc aggccagtct ccaaagctgc tcatctacaa agtttccaac      240

cgattttctg gggtcccaga cagatttagc ggatctggct ctgggaccga tttcacactc      300

aagatcagta gagtggaggc tgaggatctg ggagtttatt actgctttca aggttcacat      360

gttcctcgga cgtccggtgg aggcacaaag ctggaaatca agggaggtgg cggctctgga      420

ggcggaggta gcggaggtgg aggctctggt ggccaggtcc agctgcagca gtctggacct      480

gagctggtga agccaggggc ttcagtgagg atatcctgta aggcctctgg ctacaccttt      540

acaagttacc atatacattg ggtgaagcag aggcctggac agggactcga atggattgga      600

tggatttatc ctggaaatgt taatactgag tacaatgaga agttcaaggg caaggccaca      660

ctgactgcag acaaatcgtc cagcacagcc tacatgcacc tcagcagcct gacctctgag      720

gactctgcgg tctatttctg tgccagagag gagattacct atgctatgga ttattggggt      780

caaggaacct cagtcaccgt gtcctcatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccta gtgatcctct ggagctcgtg gtctcaggac cgtctggagg cccaagctct      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac acccaccggg      960

tcggatcctc agagtggtct gggaagacac ctgggagttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctgctcctg ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggat     1260

actcggagcc cacacgatga agatccacag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagaa gggaaatggc ctctcctcct tccccactgt ctggagagtt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagct     1440

cctcaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccacggat ccggagaggg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac     1620

cctggcccca tggacatgag ggtccccgct cagctcctgg ggctcctgct actctggctc     1680

cgaggtgcca gatgtcaggt gcagctgaag cagtccggcc ccggcctggt gcagccctcc     1740

cagtccctgt ccatcacctg caccgtgtcc ggcttctccc tgaccaacta cggcgtgcac     1800

tgggtgcggc agtcccccgg caagggcctg gagtggctgg gcgtgatctg gtccggcggc     1860

aacaccgact acaacacccc cttcacctcc cggctgtcca tcaacaagga caactccaag     1920

tcccaggtgt tcttcaagat gaactccctg cagtccaacg acaccgccat ctactactgc     1980

gcccgggccc tgacctacta cgactacgag ttcgcctact ggggccaggg caccctggtg     2040

accgtgtccg ccggcggagg tggaagcgga gggggaggat ctggcggcgg aggaagcgga     2100

ggcgacatcc tgctgaccca gtcccccgtg atcctgtccg tgtcccccgg cgagcgggtg     2160

tccttctcct gccgggcctc ccagtccatc ggcaccaaca tccactggta ccagcagcgg     2220

accaacggct ccccccggct gctgatcaag tacgcctccg agtccatctc cggcatcccc     2280

tcccggttct ccggctccgg ctccggcacc gacttcaccc tgtccatcaa ctccgtggag     2340

tccgaggaca tcgccgacta ctactgccag cagaacaaca actggcccac caccttcggc     2400

gccggcacca agctggagct gaagaccacg acgccagcgc cgcgaccacc aacaccggcg     2460

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     2520

ggcgcagtgc acacgagggg gctggacttc gcctgtgatt tctgggtgct ggtcgttgtg     2580

ggcggcgtgc tggcctgcta cagcctgctg gtgacagtgg ccttcatcat cttttgggtg     2640

aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct     2700

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg     2760

agcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gaggccagta     2820

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2880

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     2940

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     3000

cgtagaggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     3060

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     3120

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggactcag tacagccacc     3180

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  3228


<210>  190
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1765-T2A-CT486 Prot

<400>  190

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Ser Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn 
        195                 200                 205             


Thr Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Gly Ser Gly Glu Gly Arg 
        515                 520                 525             


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu 
545                 550                 555                 560 


Arg Gly Ala Arg Cys Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu 
                565                 570                 575     


Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
            580                 585                 590         


Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys 
        595                 600                 605             


Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr 
    610                 615                 620                 


Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys 
625                 630                 635                 640 


Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala 
                645                 650                 655     


Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala 
            660                 665                 670         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Leu 
    690                 695                 700                 


Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val 
705                 710                 715                 720 


Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp 
                725                 730                 735     


Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala 
            740                 745                 750         


Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile 
    770                 775                 780                 


Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly 
785                 790                 795                 800 


Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro 
                805                 810                 815     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            820                 825                 830         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        835                 840                 845             


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    850                 855                 860                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
865                 870                 875                 880 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                885                 890                 895     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            900                 905                 910         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        915                 920                 925             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    930                 935                 940                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
945                 950                 955                 960 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                965                 970                 975     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            980                 985                 990         


Glu Glu Tyr Asp Val Leu Asp Lys  Arg Arg Gly Arg Asp  Pro Glu Met 
        995                 1000                 1005             


Gly Gly  Lys Pro Arg Arg Lys  Asn Pro Gln Glu Gly  Leu Tyr Asn 
    1010                 1015                 1020             


Glu Leu  Gln Lys Asp Lys Met  Ala Glu Ala Tyr Ser  Glu Ile Gly 
    1025                 1030                 1035             


Met Lys  Gly Glu Arg Arg Arg  Gly Lys Gly His Asp  Gly Leu Tyr 
    1040                 1045                 1050             


Gln Gly  Leu Ser Thr Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His 
    1055                 1060                 1065             


Met Gln  Ala Leu Pro Pro Arg  
    1070                 1075 


<210>  191
<211>  3228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C2162-T2A-CT486 DNA

<400>  191
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgccagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg gtcctcagtg      120

aaggtttcct gcaaggcttc tggatacacc ttcactagct atcatataca ttgggtgcgc      180

caggcccccg gacaagggct tgagtggatc ggatggatct accctggcaa tgttaacaca      240

gaatataatg agaagttcaa gggcaaagcc accattaccg cggacgaatc cacgaacaca      300

gcctacatgg agctgagcag cctgagatct gaagacacgg ctgtgtatta ctgtgcgagg      360

gaggaaatta cctacgctat ggactactgg ggccagggaa ccctggtcac cgtgtcctca      420

ggaggtggcg gctctggagg cggaggtagc ggaggtggag gctctggtgg cgacattcaa      480

atgacccaga gcccatccac cctgagcgca tctgtaggtg accgggtcac catcacttgt      540

agatccagtc agagtattgt acacagtaat gggaacacct atttggaatg gtatcagcag      600

aaaccaggta aagccccaaa attgctcatc tacaaagtct ctaacagatt tagtggtgta      660

ccagccaggt tcagcggttc cggaagtggt actgaattca ccctcacgat ctcctctctc      720

cagccagatg atttcgccac ttattactgt tttcaaggtt cacatgtgcc gcgcacattc      780

ggtcagggta ctaaagtaga agtcaaatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccta gtgatcctct ggagctcgtg gtctcaggac cgtctggagg cccaagctct      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac acccaccggg      960

tcggatcctc agagtggtct gggaagacac ctgggagttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctgctcctg ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggat     1260

actcggagcc cacacgatga agatccacag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagaa gggaaatggc ctctcctcct tccccactgt ctggagagtt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagct     1440

cctcaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccacggat ccggagaggg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac     1620

cctggcccca tggacatgag ggtccccgct cagctcctgg ggctcctgct actctggctc     1680

cgaggtgcca gatgtcaggt gcagctgaag cagtccggcc ccggcctggt gcagccctcc     1740

cagtccctgt ccatcacctg caccgtgtcc ggcttctccc tgaccaacta cggcgtgcac     1800

tgggtgcggc agtcccccgg caagggcctg gagtggctgg gcgtgatctg gtccggcggc     1860

aacaccgact acaacacccc cttcacctcc cggctgtcca tcaacaagga caactccaag     1920

tcccaggtgt tcttcaagat gaactccctg cagtccaacg acaccgccat ctactactgc     1980

gcccgggccc tgacctacta cgactacgag ttcgcctact ggggccaggg caccctggtg     2040

accgtgtccg ccggcggagg tggaagcgga gggggaggat ctggcggcgg aggaagcgga     2100

ggcgacatcc tgctgaccca gtcccccgtg atcctgtccg tgtcccccgg cgagcgggtg     2160

tccttctcct gccgggcctc ccagtccatc ggcaccaaca tccactggta ccagcagcgg     2220

accaacggct ccccccggct gctgatcaag tacgcctccg agtccatctc cggcatcccc     2280

tcccggttct ccggctccgg ctccggcacc gacttcaccc tgtccatcaa ctccgtggag     2340

tccgaggaca tcgccgacta ctactgccag cagaacaaca actggcccac caccttcggc     2400

gccggcacca agctggagct gaagaccacg acgccagcgc cgcgaccacc aacaccggcg     2460

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     2520

ggcgcagtgc acacgagggg gctggacttc gcctgtgatt tctgggtgct ggtcgttgtg     2580

ggcggcgtgc tggcctgcta cagcctgctg gtgacagtgg ccttcatcat cttttgggtg     2640

aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct     2700

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg     2760

agcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gaggccagta     2820

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2880

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     2940

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     3000

cgtagaggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     3060

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     3120

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggactcag tacagccacc     3180

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctag                  3228


<210>  192
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2162-T2A-CT486 Prot

<400>  192

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr 
65                  70                  75                  80  


Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser His Val 
                245                 250                 255     


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Val Lys Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Gly Ser Gly Glu Gly Arg 
        515                 520                 525             


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu 
545                 550                 555                 560 


Arg Gly Ala Arg Cys Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu 
                565                 570                 575     


Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe 
            580                 585                 590         


Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys 
        595                 600                 605             


Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr 
    610                 615                 620                 


Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys 
625                 630                 635                 640 


Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala 
                645                 650                 655     


Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala 
            660                 665                 670         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Leu 
    690                 695                 700                 


Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val 
705                 710                 715                 720 


Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp 
                725                 730                 735     


Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala 
            740                 745                 750         


Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile 
    770                 775                 780                 


Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly 
785                 790                 795                 800 


Ala Gly Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro 
                805                 810                 815     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            820                 825                 830         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        835                 840                 845             


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    850                 855                 860                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
865                 870                 875                 880 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                885                 890                 895     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            900                 905                 910         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        915                 920                 925             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    930                 935                 940                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
945                 950                 955                 960 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                965                 970                 975     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            980                 985                 990         


Glu Glu Tyr Asp Val Leu Asp Lys  Arg Arg Gly Arg Asp  Pro Glu Met 
        995                 1000                 1005             


Gly Gly  Lys Pro Arg Arg Lys  Asn Pro Gln Glu Gly  Leu Tyr Asn 
    1010                 1015                 1020             


Glu Leu  Gln Lys Asp Lys Met  Ala Glu Ala Tyr Ser  Glu Ile Gly 
    1025                 1030                 1035             


Met Lys  Gly Glu Arg Arg Arg  Gly Lys Gly His Asp  Gly Leu Tyr 
    1040                 1045                 1050             


Gln Gly  Leu Ser Thr Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His 
    1055                 1060                 1065             


Met Gln  Ala Leu Pro Pro Arg  
    1070                 1075 


<210>  193
<211>  3228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1765-T2A-CT488 DNA

<400>  193
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgcgatg ttctgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa      120

gcctccatct cttgcagatc tagtcagagc attgtacata gtaatggaaa cacctattta      180

gaatggtacc tgcagaagcc aggccagtct ccaaagctgc tcatctacaa agtttccaac      240

cgattttctg gggtcccaga cagatttagc ggatctggct ctgggaccga tttcacactc      300

aagatcagta gagtggaggc tgaggatctg ggagtttatt actgctttca aggttcacat      360

gttcctcgga cgtccggtgg aggcacaaag ctggaaatca agggaggtgg cggctctgga      420

ggcggaggta gcggaggtgg aggctctggt ggccaggtcc agctgcagca gtctggacct      480

gagctggtga agccaggggc ttcagtgagg atatcctgta aggcctctgg ctacaccttt      540

acaagttacc atatacattg ggtgaagcag aggcctggac agggactcga atggattgga      600

tggatttatc ctggaaatgt taatactgag tacaatgaga agttcaaggg caaggccaca      660

ctgactgcag acaaatcgtc cagcacagcc tacatgcacc tcagcagcct gacctctgag      720

gactctgcgg tctatttctg tgccagagag gagattacct atgctatgga ttattggggt      780

caaggaacct cagtcaccgt gtcctcatac ggctcacaga gctccaaacc ctacctgctg      840

actcacccta gtgatcctct ggagctcgtg gtctcaggac cgtctggagg cccaagctct      900

ccgacaacag gccccacctc cacatctggc cctgaggacc agcccctcac acccaccggg      960

tcggatcctc agagtggtct gggaagacac ctgggagttg tgatcggcat cttggtggcc     1020

gtcatcctac tgctcctcct cctgctcctg ctcttcctca tcctccgaca tcgacgtcag     1080

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg     1140

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag     1200

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggat     1260

actcggagcc cacacgatga agatccacag gcagtgacgt atgccgaggt gaaacactcc     1320

agacctagaa gggaaatggc ctctcctcct tccccactgt ctggagagtt cctggacaca     1380

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagct     1440

cctcaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag     1500

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc     1560

atccacggat ccggagaggg cagaggcagc ctgctgacat gtggcgacgt ggaagagaac     1620

cctggcccca tggacatgag ggtccccgct cagctcctgg ggctcctgct actctggctc     1680

cgaggtgcca gatgtcaggt gcagctgcag gagtccggcc ccggcctggt gaagccctcc     1740

gagaccctgt ccctgacctg caccgtgtcc ggcggctccg tgtcctccgg cgactactac     1800

tggacctgga tccggcagtc ccccggcaag ggcctggagt ggatcggcca catctactac     1860

tccggcaaca ccaactacaa cccctccctg aagtcccggc tgaccatctc catcgacacc     1920

tccaagaccc agttctccct gaagctgtcc tccgtgaccg ccgccgacac cgccatctac     1980

tactgcgtgc gggaccgggt gaccggcgcc ttcgacatct ggggccaggg caccatggtg     2040

accgtgtcct ccggcggagg tggaagcgga gggggaggat ctggcggcgg aggaagcgga     2100

ggcgacatcc agatgaccca gtccccctcc tccctgtccg cctccgtggg cgaccgggtg     2160

accatcacct gccaggcctc ccaggacatc tccaactacc tgaactggta ccagcagaag     2220

cccggcaagg cccccaagct gctgatctac gacgcctcca acctggagac cggcgtgccc     2280

tcccggttct ccggctccgg ctccggcacc gacttcacct tcaccatctc ctccctgcag     2340

cccgaggaca tcgccaccta cttctgccag cacttcgacc acctgcccct ggccttcggc     2400

ggcggcacca aggtggagat caagaccacg acgccagcgc cgcgaccacc aacaccggcg     2460

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     2520

ggcgcagtgc acacgagggg gctggacttc gcctgtgatt tctgggtgct ggtcgttgtg     2580

ggcggcgtgc tggcctgcta cagcctgctg gtgacagtgg ccttcatcat cttttgggtg     2640

aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct     2700

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg     2760

agcaaacggg gcagaaagaa actcctgtat atattcaaac aaccatttat gaggccagta     2820

caaactactc aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga     2880

tgtgaactga gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     2940

aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     3000

cgtagaggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     3060

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     3120

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggactcag tacagccacc     3180

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgctaa                  3228


<210>  194
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1765-T2A-CT488 Prot

<400>  194

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Ser Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr His Ile His Trp Val Lys Gln Arg Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn 
        195                 200                 205             


Thr Glu Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Phe Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Tyr Gly Ser 
            260                 265                 270         


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
        275                 280                 285             


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
    290                 295                 300                 


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
305                 310                 315                 320 


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
                325                 330                 335     


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
        355                 360                 365             


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
    370                 375                 380                 


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
385                 390                 395                 400 


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
                405                 410                 415     


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
            420                 425                 430         


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
        435                 440                 445             


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
    450                 455                 460                 


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
465                 470                 475                 480 


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
                485                 490                 495     


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
            500                 505                 510         


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His Gly Ser Gly Glu Gly Arg 
        515                 520                 525             


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    530                 535                 540                 


Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu 
545                 550                 555                 560 


Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu 
                565                 570                 575     


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly 
            580                 585                 590         


Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro 
        595                 600                 605             


Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr 
    610                 615                 620                 


Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr 
625                 630                 635                 640 


Ser Lys Thr Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
                645                 650                 655     


Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp 
            660                 665                 670         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    690                 695                 700                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
705                 710                 715                 720 


Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp 
                725                 730                 735     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
            740                 745                 750         


Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        755                 760                 765             


Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
    770                 775                 780                 


Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu Ala Phe Gly 
785                 790                 795                 800 


Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
                805                 810                 815     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            820                 825                 830         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        835                 840                 845             


Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    850                 855                 860                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
865                 870                 875                 880 


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                885                 890                 895     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            900                 905                 910         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        915                 920                 925             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    930                 935                 940                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
945                 950                 955                 960 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                965                 970                 975     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            980                 985                 990         


Glu Glu Tyr Asp Val Leu Asp Lys  Arg Arg Gly Arg Asp  Pro Glu Met 
        995                 1000                 1005             


Gly Gly  Lys Pro Arg Arg Lys  Asn Pro Gln Glu Gly  Leu Tyr Asn 
    1010                 1015                 1020             


Glu Leu  Gln Lys Asp Lys Met  Ala Glu Ala Tyr Ser  Glu Ile Gly 
    1025                 1030                 1035             


Met Lys  Gly Glu Arg Arg Arg  Gly Lys Gly His Asp  Gly Leu Tyr 
    1040                 1045                 1050             


Gln Gly  Leu Ser Thr Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His 
    1055                 1060                 1065             


Met Gln  Ala Leu Pro Pro Arg  
    1070                 1075 


<210>  195
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002166 BB7.2.2 scFv (humanized)

<400>  195
gaggtgcagc tggtgcagtc tggggccgag ctgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt aaaacaggcc      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agccacgctt accgtggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccat ccaccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagcag cttgcagccc      660

gatgacttcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggcag      720

ggcacgaaag tggaagttaa g                                                741


<210>  196
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002167 BB7.2.3 scFv (humanized)

<400>  196
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctacaag gtgagcaacc ggttctccgg catccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  197
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002168 BB7.2.5 scFv (humanized)

<400>  197
caggtgaccc tgaagcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcacgg cttctggata caccttcacc agctatcatg tcagctgggt acgacaggcc      120

cctggacaag ggcttgagtg gttgggaagg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt accgcggaca aatccatgga cacatccttc      240

atggagctga ccagcctgac atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacct ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg cgtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctccaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgccaacag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  198
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002169 BB7.2.6 scFv (humanized)

<400>  198
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tgcactgggt acgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt acccgggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat cgtcatgacc      420

cagaccccac tgtccctgcc tgtgaccccg ggcgagcccg cgagcatcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg actggtacct gcagaagccc      540

gggcagtccc cgcaactgct catctacaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca agattagccg cgtggaggcc      660

gaagacgtcg gcgtgtacta ctgcatgcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  199
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.10_scFv

<400>  199

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  200
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.9_scFv

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  201
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.8_scFv

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  202
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.7_scFv

<400>  202

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  203
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.6_scFv

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  204
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.5_scFv

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  205
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.4_scFv

<400>  205

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  206
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.3_scFv

<400>  206

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  207
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.2_scFv

<400>  207

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  208
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-B*07 antigen binding domain BB7.1.1_scFv

<400>  208

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp 
        35                  40                  45              


Leu Gly Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Val Ser His Tyr Ala Met Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Thr Tyr Leu Pro 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Phe Trp Val Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  209
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 9

<400>  209

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Ser Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  210
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 8

<400>  210

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Arg His Met Arg Leu Ser Cys Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  211
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 7

<400>  211

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asn Gly Ala Asn Pro Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  212
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 6

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Pro Gly Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  213
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 5

<400>  213

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Tyr Leu Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  214
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 4

<400>  214

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Cys Leu Gly Val Leu Leu Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  215
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 3

<400>  215

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  216
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 2

<400>  216

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Lys Thr Thr Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  217
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 antigen binding domain 1

<400>  217

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  218
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-45

<400>  218

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ser Phe Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  219
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-44

<400>  219

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Arg Ser Ile Ser Pro Tyr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  220
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-43

<400>  220

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Val Ile Trp Tyr Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Ser Val Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
                165                 170                 175     


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu 
                245         


<210>  221
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-42

<400>  221

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Ile Leu Pro Arg Leu Ser Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  222
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-41

<400>  222

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Ala His Ser Ser Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  223
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-40

<400>  223

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  224
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-39

<400>  224

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Thr Val Ile His Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  225
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-38

<400>  225

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Val Ile Val Glu Val Phe Leu Ser Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  226
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-37

<400>  226

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ile Phe Ile His Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  227
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-36

<400>  227

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Thr Phe Tyr Ser Tyr Ser Pro Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  228
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-35

<400>  228

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Trp Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr 
            100                 105                 110         


Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  229
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-34

<400>  229

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ser Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  230
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-33

<400>  230

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Lys Ile Leu Ala Pro Asn Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  231
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-32

<400>  231

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Ser Trp Lys Tyr Phe Tyr Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  232
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-31

<400>  232

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asn Thr Ser Thr Ile Pro Tyr Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  233
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-30

<400>  233

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  234
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-29

<400>  234

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Asp Ile Val Ser Ser Ser Ala Ile Tyr Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala 
    130                 135                 140                 


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu 
                165                 170                 175     


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  235
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-28

<400>  235

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Ile Leu Pro Pro Tyr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  236
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-27

<400>  236

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Thr Trp Ile Lys Ile Leu Pro Arg Tyr Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  237
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-26

<400>  237

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Ser Arg Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  238
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-25

<400>  238

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Val Leu Cys Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu 
                165                 170                 175     


Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  239
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-24

<400>  239

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Lys Ile Leu Pro Arg Pro Tyr Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  240
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-23

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asn Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  241
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-22

<400>  241

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Phe Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Cys Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  242
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-21

<400>  242

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Glu Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  243
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-20

<400>  243

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Asp Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  244
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-19

<400>  244

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Trp Ser Thr Asn Ile Leu Leu Ser Tyr Thr Lys Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  245
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-18

<400>  245

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Lys Thr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  246
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-17

<400>  246

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Tyr Phe His Asp Lys Tyr Phe His Asp Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  247
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-16

<400>  247

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Thr Ser Val Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  248
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-15

<400>  248

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Ile Leu Pro Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  249
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-14

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gln Trp Ile Tyr Ile Tyr Ile Asn Pro Arg Gly Phe Ile Phe 
            100                 105                 110         


Leu His Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
145                 150                 155                 160 


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
                165                 170                 175     


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
    210                 215                 220                 


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
225                 230                 235                 240 


Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                245                 250                 255     


Leu 
    


<210>  250
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-13

<400>  250

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Glu Asp Val Asp Phe His His Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  251
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-12

<400>  251

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gly Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
                165                 170                 175     


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250             


<210>  252
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-11

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys 
                165                 170                 175     


Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  253
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-10

<400>  253

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Ile His Val Asp Ile Arg Ser Met Glu Asp Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  254
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-9

<400>  254

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ile Gly Thr Ser Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  255
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-8

<400>  255

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Val Val Glu Val Phe Leu Tyr Tyr Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  256
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-7

<400>  256

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Tyr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  257
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-6

<400>  257

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Ser Ile Phe 
            100                 105                 110         


Ile His Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                165                 170                 175     


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            180                 185                 190         


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
225                 230                 235                 240 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250                 255     


<210>  258
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-5

<400>  258

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  259
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-4

<400>  259

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Lys Tyr Phe His Asp Trp Leu Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  260
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-3

<400>  260

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Leu Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  261
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-2

<400>  261

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gln Asn Glu Tyr Phe Gln His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  262
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-C*07 antigen binding domain C7-1

<400>  262

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Asn Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
145                 150                 155                 160 


Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
    210                 215                 220                 


Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  263
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 15

<400>  263

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Val Ser Gln Arg Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  264
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 16

<400>  264

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Pro Asp Lys Asp Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  265
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 17

<400>  265

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Phe Tyr Cys Thr Asn Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  266
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 18

<400>  266

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ser Ser Ser Gly Ser Tyr Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  267
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 19

<400>  267

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Tyr Lys Tyr Asn Leu Tyr Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  268
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 20

<400>  268

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr 
    130                 135                 140                 


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
145                 150                 155                 160 


Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr 
            180                 185                 190         


Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
        195                 200                 205             


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  269
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 21

<400>  269

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Arg Arg Tyr Asn Ser Cys Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  270
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 22

<400>  270

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Leu Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr 
    130                 135                 140                 


Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
145                 150                 155                 160 


Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr 
            180                 185                 190         


Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu 
        195                 200                 205             


Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  271
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 23

<400>  271

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Thr Leu Leu Ser Leu Ser Tyr Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  272
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 24

<400>  272

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Leu Ser His Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln 
    130                 135                 140                 


Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
145                 150                 155                 160 


Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr Ser 
            180                 185                 190         


Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
        195                 200                 205             


Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
    210                 215                 220                 


Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  273
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 25

<400>  273

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Asp Arg Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  274
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 26

<400>  274

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Pro Pro Ser Leu Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Pro Ser Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr 
145                 150                 155                 160 


Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu 
                245         


<210>  275
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 27

<400>  275

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ala Tyr Cys Leu Ser Asp Ser Tyr Trp Tyr Phe Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  276
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*03 scFv 28

<400>  276

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  277
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-9

<400>  277

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Thr Ala Trp Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Thr Val Val Thr Gln 
    130                 135                 140                 


Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys 
145                 150                 155                 160 


Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ser Thr Ser 
            180                 185                 190         


Asn Lys His Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly 
        195                 200                 205             


Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala 
    210                 215                 220                 


Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  278
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-8

<400>  278

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Lys Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gln Ser Val Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly 
                165                 170                 175     


Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  279
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-7

<400>  279

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gln Val Asp Lys Asn Thr Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  280
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-6

<400>  280

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Cys Gln Leu Ala Glu Tyr Phe Gln His Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  281
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-5

<400>  281

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
            180                 185                 190         


Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
    210                 215                 220                 


Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  282
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-4

<400>  282

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Val Gln Leu Lys Leu Val His Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  283
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-3

<400>  283

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asp Tyr Val Thr Val Phe Tyr Phe Gln His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  284
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-2

<400>  284

Gln Leu Gln Leu Gln Glu Ser Gly Ser Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Ser Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Arg Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Tyr Pro Ser Phe Tyr Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  285
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*01 scFv A1-1

<400>  285

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ser Asn Met Trp Ser Tyr Ser Leu Asn Asp Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  286
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  286

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  287
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  287

Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10                  


<210>  288
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  288

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  289
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  289

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  290
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  290

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  291
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  291

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  292
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  292

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  293
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  293

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  294
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  294

Ser Thr Ser Asn Lys His Ser 
1               5           


<210>  295
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  295

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  296
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  296

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2

<400>  297

Ala Ala Thr Tyr Leu Pro Asp 
1               5           


<210>  298
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  298

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  299
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  299

Leu Leu Tyr Tyr Gly Gly Ala Gln Trp Val 
1               5                   10  


<210>  300
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  300

Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val 
1               5                   10  


<210>  301
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  301

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  302
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  302

Gln His Phe Trp Val Thr Pro Tyr Thr 
1               5                   


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  303

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  304
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3

<400>  304

Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  305
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  305

Ser Tyr Gly Ile Ser 
1               5   


<210>  306
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  306

Ser Tyr Ser Met Asn 
1               5   


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  307

Ser Gly Ser Tyr Tyr Trp Ser 
1               5           


<210>  308
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  308

Ser Tyr Tyr Trp Ser 
1               5   


<210>  309
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  309

Ser Tyr Trp Ile Gly 
1               5   


<210>  310
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  310

Ser Asn Tyr Met Ser 
1               5   


<210>  311
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  311

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  312
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  312

Ser Gly Gly Tyr Tyr Trp Ser 
1               5           


<210>  313
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  313

Ser Gly Tyr Ser Trp His 
1               5       


<210>  314
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  314

Thr Ser Gly Val Gly Val Gly 
1               5           


<210>  315
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  315

Ser Tyr Trp Met His 
1               5   


<210>  316
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  316

Ser Tyr Asp Met His 
1               5   


<210>  317
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  317

Ser Tyr Ala Met His 
1               5   


<210>  318
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  318

Ser Tyr Ala Met Ser 
1               5   


<210>  319
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  319

Ser Tyr Ala Met Asn 
1               5   


<210>  320
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  320

Asp Tyr Tyr Met Ser 
1               5   


<210>  321
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  321

Ser Asn Ser Ala Ala Trp Asn 
1               5           


<210>  322
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  322

Asp Tyr Tyr Met His 
1               5   


<210>  323
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  323

Ser Ser Asn Trp Trp Gly 
1               5       


<210>  324
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  324

Ser Tyr Asp Ile Asn 
1               5   


<210>  325
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1

<400>  325

Ser Gly Gly Tyr Ser Trp Ser 
1               5           


<210>  326
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  326

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  327
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  327

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  328
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  328

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  329
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  329

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  330
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  330

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  331
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  331

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  332
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  332

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  333
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  333

Tyr Ile His Phe Ser Gly Ser Thr His Tyr His Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  334
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  334

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  335
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  335

Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  336
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  336

Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys Gly 
1               5                   10                  15      


<210>  337
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  337

Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  338
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  338

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  339
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  339

Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  340
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  340

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  341
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  341

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  342
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  342

Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  343
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  343

Trp Met Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  344
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  344

Tyr Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  345
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  345

Glu Arg Val Ser Gln Arg Gly Ala Phe Asp Ile 
1               5                   10      


<210>  346
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  346

Gly Asn Pro Asp Lys Asp Pro Phe Asp Tyr 
1               5                   10  


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  347

Asp Phe Tyr Cys Thr Asn Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  348
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  348

Glu Ser Ser Ser Gly Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  349
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  349

Asp Ser Gly Tyr Lys Tyr Asn Leu Tyr Tyr Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  350
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  350

Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10              


<210>  351
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  351

Glu Asn Arg Arg Tyr Asn Ser Cys Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  352
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  352

Gly Gly Asp Leu Ser His Tyr Tyr Tyr Tyr Leu Asp Val 
1               5                   10              


<210>  353
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  353

Ala Thr Leu Leu Ser Leu Ser Tyr Asp Ala Phe Asp Ile 
1               5                   10              


<210>  354
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  354

Gly Gly Asp Leu Ser His Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  355
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  355

Glu Arg Asp Arg Trp Phe Asp Pro 
1               5               


<210>  356
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  356

Glu Thr Pro Pro Ser Leu Gly Ala Phe Asp Ile 
1               5                   10      


<210>  357
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  357

Glu Ala Tyr Cys Leu Ser Asp Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  358
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  358

Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Tyr Met Asp Val 
1               5                   10                  


<210>  359
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  359

Gly Gly Val Val Ser His Tyr Ala Met Asp Cys 
1               5                   10      


<210>  360
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  360

His Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   


<210>  361
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  361

Lys Thr Thr Ser Phe Tyr Phe Asp Tyr 
1               5                   


<210>  362
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  362

His Tyr Tyr Tyr Tyr Met Asp Val 
1               5               


<210>  363
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  363

Gly Val Leu Leu Tyr Asn Trp Phe Asp Pro 
1               5                   10  


<210>  364
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  364

His Tyr Tyr Tyr Tyr Tyr Leu Asp Val 
1               5                   


<210>  365
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  365

Asp Leu Pro Gly Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  366
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  366

Glu Gly Asn Gly Ala Asn Pro Asp Ala Phe Asp Ile 
1               5                   10          


<210>  367
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  367

Arg His Met Arg Leu Ser Cys Phe Asp Tyr 
1               5                   10  


<210>  368
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  368

His Tyr Tyr Tyr Tyr Ser Met Asp Val 
1               5                   


<210>  369
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  369

Ser Phe Asp Trp Phe Asp Pro 
1               5           


<210>  370
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  370

Glu Arg Ser Ile Ser Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  371
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  371

Asp Ser Val Ile Trp Tyr Trp Phe Asp Pro 
1               5                   10  


<210>  372
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  372

Glu Glu Ile Leu Pro Arg Leu Ser Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  373
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2

<400>  373

Gly Gly Arg Ala His Ser Ser Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  374
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  374

Asp Arg Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  375
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  375

Asp Thr Val Ile His Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  376
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  376

Asp Val Ile Val Glu Val Phe Leu Ser Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  377
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  377

Asp Ile Phe Ile His Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  378
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  378

Asp Gly Thr Phe Tyr Ser Tyr Ser Pro Tyr Tyr Phe Asp Tyr 
1               5                   10                  


<210>  379
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  379

Glu Trp Ile Lys Ile Leu Pro Arg Leu Gly Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  380
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  380

Asp Arg Ser Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  381
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  381

Asp Lys Ile Leu Ala Pro Asn Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  382
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  382

Glu Lys Ser Trp Lys Tyr Phe Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  383
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  383

Glu Asn Thr Ser Thr Ile Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  384
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  384

Glu Asp Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  385
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  385

Asp Gly Gly Asp Ile Val Ser Ser Ser Ala Ile Tyr Trp Tyr Phe Asp 
1               5                   10                  15      


Leu 
    


<210>  386
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  386

Asp Leu Ile Leu Pro Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  387
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  387

Glu Thr Trp Ile Lys Ile Leu Pro Arg Tyr Tyr Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  388
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  388

Asp Leu Ser Arg Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  389
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  389

Glu His Ile Val Leu Cys Phe Asp Tyr 
1               5                   


<210>  390
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  390

Asp Lys Ile Leu Pro Arg Pro Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  391
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  391

Gly Ser Asn Glu Tyr Phe Gln His 
1               5               


<210>  392
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  392

Gly Thr Ser Tyr Trp Tyr Phe Asp Leu 
1               5                   


<210>  393
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  393

Glu Glu Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  394
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  394

Val Asp Asp Tyr Tyr Phe Asp Tyr 
1               5               


<210>  395
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  395

Ser Thr Asn Ile Leu Leu Ser Tyr Thr Lys Ala Phe Asp Ile 
1               5                   10                  


<210>  396
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  396

Asp Lys Thr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  397
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  397

Glu Lys Tyr Phe His Asp Lys Tyr Phe His Asp Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  398
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  398

Asp Thr Ser Val Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  399
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  399

Glu Lys Ile Leu Pro Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  400
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  400

Gln Trp Ile Tyr Ile Tyr Ile Asn Pro Arg Gly Phe Ile Phe Leu His 
1               5                   10                  15      


Asp Ala Phe Asp Ile 
            20      


<210>  401
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  401

Glu Asp Val Asp Phe His His Asp Ala Phe Asp Ile 
1               5                   10          


<210>  402
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  402

Glu Gly Val Asp Lys Asn Thr Ser Thr Ile Tyr Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  403
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  403

Asp Arg Arg Gly Tyr Phe Asp Leu 
1               5               


<210>  404
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  404

Gly Ile His Val Asp Ile Arg Ser Met Glu Asp Trp Phe Asp Pro 
1               5                   10                  15  


<210>  405
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  405

Asp Ile Gly Thr Ser Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  406
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  406

Glu Val Val Glu Val Phe Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  407
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  407

Asp Leu Tyr Tyr Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  408
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  408

Glu Ser Trp Lys Tyr Phe Tyr Pro Arg Gly Ser Ile Phe Ile His Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Met Asp Val 
            20          


<210>  409
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  409

Asp Arg Ile Val Glu Val Phe Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  410
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  410

Glu Lys Tyr Phe His Asp Trp Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  411
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  411

Asp Leu Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  412
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  412

Val Gln Asn Glu Tyr Phe Gln His 
1               5               


<210>  413
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  413

Ala Asn Trp Phe Asp Pro 
1               5       


<210>  414
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  414

Gly Gly Trp Thr Ala Trp Tyr Tyr Tyr Met Asp Val 
1               5                   10          


<210>  415
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  415

Ala Lys Tyr Tyr Tyr Met Asp Val 
1               5               


<210>  416
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  416

Asp Gln Val Asp Lys Asn Thr Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  417
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  417

Ala Cys Gln Leu Ala Glu Tyr Phe Gln His 
1               5                   10  


<210>  418
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  418

Asp Arg Val Asp Lys Asn Thr Ser Tyr Tyr Tyr Met Asp Val 
1               5                   10                  


<210>  419
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  419

Arg Val Gln Leu Lys Leu Val His Trp Phe Asp Pro 
1               5                   10          


<210>  420
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  420

Tyr Tyr Asp Tyr Val Thr Val Phe Tyr Phe Gln His 
1               5                   10          


<210>  421
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  421

Glu Ser Tyr Pro Ser Phe Tyr Ala Phe Asp Ile 
1               5                   10      


<210>  422
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3

<400>  422

Ser Asn Met Trp Ser Tyr Ser Leu Asn Asp Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  423
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  immunoreceptor tyrosine-based inhibitory motif


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa is Ser, Ile, Val or Leu

<220>
<221>  SITE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (4)..(5)
<223>  Xaa is any amino acid

<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa is Ile, Val or Leu

<400>  423

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


<210>  424
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge (iTIM hinge)

<400>  424

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


<210>  425
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Short hinge 2

<400>  425

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
        35                  40                  


<210>  426
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long hinge 1

<400>  426

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


Ala Ser Val 
65          


<210>  427
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Long hinge 2

<400>  427

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr 
        35                  40                  45              


Pro Ser Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser 
    50                  55                  60                  


Thr Pro Pro Thr Pro Ser Pro Ser Ala Ser Val 
65                  70                  75  


<210>  428
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2x short hinge

<400>  428

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Val Val Ser Gly Pro Ser Gly 
        35                  40                  45              


Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu 
    50                  55                  60                  


Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly 
65                  70                  75                  80  


Arg His Leu Gly Val 
                85  


<210>  429
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge (truncated)

<400>  429

Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
1               5                   10                  15      


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
            20                  25                  30          


<210>  430
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide

<400>  430

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  431
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A self-cleaving peptide

<400>  431

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  432
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A self-cleaving peptide

<400>  432

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  433
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A self-cleaving peptide

<400>  433

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  434
<211>  63
<212>  DNA
<213>  Unknown

<220>
<223>  encodes T2A self-cleaving peptide

<400>  434
ggatccggag agggcagagg cagcctgctg acatgtggcg acgtggaaga gaaccctggc       60

ccc                                                                     63


<210>  435
<211>  83
<212>  DNA
<213>  Unknown

<220>
<223>  encodes scaffold sequence

<400>  435
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt ttt                                               83


<210>  436
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  436
tggacgacac gcagttcgtg                                                   20


<210>  437
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  437
cagatacctg gagaacggga                                                   20


<210>  438
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  438
tcccgttctc caggtatctg                                                   20


<210>  439
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  439
ccgccgcggt ccaagagcgc                                                   20


<210>  440
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  440
cctgcgctct tggaccgcgg                                                   20


<210>  441
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  441
ggacctgcgc tcttggaccg c                                                 21


<210>  442
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  442
aaggagacgc tgcagcgcac ggg                                               23


<210>  443
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  443
gaaggagacg ctgcagcgca cgg                                               23


<210>  444
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  444
gcgggcgccg tggatagagc agg                                               23


<210>  445
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  445
tgctctatcc acggcgcccg cgg                                               23


<210>  446
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  446
cgatgaagcg gggctccccg cgg                                               23


<210>  447
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  447
cgtgtcccgg cccggccgcg ggg                                               23


<210>  448
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  448
cggctccatc ctctggctcg cgg                                               23


<210>  449
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  449
gatgtaatcc ttgccgtcgt agg                                               23


<210>  450
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  450
acagcgacgc cgcgagccag agg                                               23


<210>  451
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  451
ggatggagcc gcgggcgccg tgg                                               23


<210>  452
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  452
ggcgccgtgg atagagcagg agg                                               23


<210>  453
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  453
gcgccgtgga tagagcagga ggg                                               23


<210>  454
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  454
cggctactac aaccagagcg agg                                               23


<210>  455
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  455
ctggttgtag tagccgcgca ggg                                               23


<210>  456
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  456
tactacaacc agagcgaggc cgg                                               23


<210>  457
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  457
ctacctggag ggcacgtgcg tgg                                               23


<210>  458
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  458
cacgcacgtg ccctccaggt agg                                               23


<210>  459
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  459
gcagggtccc caggtccact cgg                                               23


<210>  460
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  460
gtggacctgg ggaccctgcg cgg                                               23


<210>  461
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  461
tggagggcac gtgcgtggag tgg                                               23


<210>  462
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  462
gtatggctgc gacgtggggt cgg                                               23


<210>  463
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  463
ctgagctgcc atgtccgccg cgg                                               23


<210>  464
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  464
ggattacatc gccctgaaag agg                                               23


<210>  465
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  465
caagtgggag gcggcccatg tgg                                               23


<210>  466
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  466
gtgggaggcg gcccatgtgg cgg                                               23


<210>  467
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  467
cagttgagag cctacctgga ggg                                               23


<210>  468
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  468
gcagttgaga gcctacctgg agg                                               23


<210>  469
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  469
taccaccagt acgcctacga cgg                                               23


<210>  470
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  470
tgccgtcgta ggcgtactgg tgg                                               23


<210>  471
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  471
ccagtacgcc tacgacggca agg                                               23


<210>  472
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  472
ggatgtgaag aaatacctca tgg                                               23


<210>  473
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  473
atttcttcac atccgtgtcc cgg                                               23


<210>  474
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  474
aggcgtactg gtggtacccg cgg                                               23


<210>  475
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  475
cgtactggtg gtacccgcgg agg                                               23


<210>  476
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  476
gaggatgtat ggctgcgacg tgg                                               23


<210>  477
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  477
ggatgtatgg ctgcgacgtg ggg                                               23


<210>  478
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  478
ctcagaccac caagcacaag tgg                                               23


<210>  479
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  479
tcagaccacc aagcacaagt ggg                                               23


<210>  480
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  480
caccaagcac aagtgggagg cgg                                               23


<210>  481
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  481
gaccaccaag cacaagtggg agg                                               23


<210>  482
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  482
gagccccgct tcatcgcagt ggg                                               23


<210>  483
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  483
gtagcccact gcgatgaagc ggg                                               23


<210>  484
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  484
tagcccactg cgatgaagcg ggg                                               23


<210>  485
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  485
cgtagcccac tgcgatgaag cgg                                               23


<210>  486
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  486
cttcatcgca gtgggctacg tgg                                               23


<210>  487
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  487
ggagccccgc ttcatcgcag tgg                                               23


<210>  488
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  488
cggggagaca cggaaagtga agg                                               23


<210>  489
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  489
agtattggga cggggagaca cgg                                               23


<210>  490
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  490
agggtccgga gtattgggac ggg                                               23


<210>  491
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  491
gagggtccgg agtattggga cgg                                               23


<210>  492
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  492
ggaccctcct gctctatcca cgg                                               23


<210>  493
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  493
gtggatagag caggagggtc cgg                                               23


<210>  494
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  494
agactcaccg agtggacctg ggg                                               23


<210>  495
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  495
cactcggtga gtctgtgagt ggg                                               23


<210>  496
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  496
cagactcacc gagtggacct ggg                                               23


<210>  497
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  497
ccactcacag actcaccgag tgg                                               23


<210>  498
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  498
ccactcggtg agtctgtgag tgg                                               23


<210>  499
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  499
tcggactggc gcttcctccg cgg                                               23


<210>  500
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  500
gcagccatac atcctctgga cgg                                               23


<210>  501
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  501
tctcaactgc tccgccacat ggg                                               23


<210>  502
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  502
accctcatgc tgcacatggc agg                                               23


<210>  503
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  503
acctgccatg tgcagcatga ggg                                               23


<210>  504
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  504
cacctgccat gtgcagcatg agg                                               23


<210>  505
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  505
ggaggaccag acccaggaca cgg                                               23


<210>  506
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  506
ggatggggag gaccagaccc agg                                               23


<210>  507
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  507
gacctggcag cgggatgggg agg                                               23


<210>  508
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  508
agatcacact gacctggcag cgg                                               23


<210>  509
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  509
gatcacactg acctggcagc ggg                                               23


<210>  510
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  510
aggtcagtgt gatctccgca ggg                                               23


<210>  511
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  511
aagcccctca ccctgagatg ggg                                               23


<210>  512
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  512
ctgcggagat cacactgacc tgg                                               23


<210>  513
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  513
cagcaatgat gcccacgatg ggg                                               23


<210>  514
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  514
ccagcaatga tgcccacgat ggg                                               23


<210>  515
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  515
gccagcaatg atgcccacga tgg                                               23


<210>  516
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  516
ggatggaacc ttccagaagt ggg                                               23


<210>  517
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  517
gggatggaac cttccagaag tgg                                               23


<210>  518
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  518
atgcccacga tggggatggt ggg                                               23


<210>  519
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  519
cagcccacca tccccatcgt ggg                                               23


<210>  520
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  520
ccagcccacc atccccatcg tgg                                               23


<210>  521
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  521
gatgcccacg atggggatgg tgg                                               23


<210>  522
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  522
cagggcccag cacctcaggg tgg                                               23


<210>  523
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  523
aatgatgccc acgatgggga tgg                                               23


<210>  524
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  524
ggccctgacc cagacctggg cgg                                               23


<210>  525
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  525
gacccaggac acggagctcg tgg                                               23


<210>  526
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  526
acacggagct cgtggagacc agg                                               23


<210>  527
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  527
cgtggagacc aggcctgcag ggg                                               23


<210>  528
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  528
tcgtggagac caggcctgca ggg                                               23


<210>  529
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  529
agctgtgatc actggagctg tgg                                               23


<210>  530
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  530
aaaaggaggg agctactctc agg                                               23


<210>  531
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  531
atgtggagga ggaagagctc agg                                               23


<210>  532
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  532
gtgtctctca cagcttgtaa agg                                               23


<210>  533
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  533
gagagacaca tcagagccct ggg                                               23


<210>  534
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  534
ctccgcaggg tagaagctca ggg                                               23


<210>  535
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  535
ggccctgagc ttctaccctg cgg                                               23


<210>  536
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  536
gctcagggcc cagcacctca ggg                                               23


<210>  537
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  537
tatctctgct cctgtccaga agg                                               23


<210>  538
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  538
agtagcagga cgagggttcg ggg                                               23


<210>  539
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  539
ccccgagagt agcaggacga ggg                                               23


<210>  540
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  540
ccctcgtcct gctactctcg ggg                                               23


<210>  541
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  541
cctcgtcctg ctactctcgg ggg                                               23


<210>  542
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  542
ctgtggtcgc tgctgtgatg tgg                                               23


<210>  543
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  543
tcgctgctgt gatgtggagg agg                                               23


<210>  544
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  544
tggtcgctgc tgtgatgtgg agg                                               23


<210>  545
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  545
cacagccgcc cacttctgga agg                                               23


<210>  546
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  546
ccagaagtgg gcggctgtgg tgg                                               23


<210>  547
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  547
tggaaccttc cagaagtggg cgg                                               23


<210>  548
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  548
tcacagctcc aaagagaacc agg                                               23


<210>  549
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  549
ctgaccatga agccaccctg agg                                               23


<210>  550
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  550
gcaaaccctc atgctgcaca tgg                                               23


<210>  551
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  551
tgaagccacc ctgaggtgct ggg                                               23


<210>  552
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  552
ggtgagtcat atgcgttttg ggg                                               23


<210>  553
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  553
gtgagtcata tgcgttttgg ggg                                               23


<210>  554
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  554
cttcatggtc agagacagcg tgg                                               23


<210>  555
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide Nucleic Acid Targeting Sequence

<400>  555
tctggccctg acccagacct ggg                                               23


<210>  556
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  556
cgcgagcaca gctaaggcca                                                   20


<210>  557
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  557
gagtagcgcg agcacagcta                                                   20


<210>  558
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  558
agggtaggag agactcacgc                                                   20


<210>  559
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  559
ctgaatcttt ggagtacctg                                                   20


<210>  560
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  560
tcacgtcatc cagcagagaa                                                   20


<210>  561
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  561
tcctgaattg ctatgtgtct                                                   20


<210>  562
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  562
aagtcaactt caatgtcgga                                                   20


<210>  563
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  563
gtcttttccc gatattcctc                                                   20


<210>  564
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  564
tggagtacct gaggaatatc                                                   20


<210>  565
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  565
cagcccaaga tagttaagtg                                                   20


<210>  566
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  566
acaaagtcac atggttcaca                                                   20


<210>  567
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  567
actctctctt tctggcctgg                                                   20


<210>  568
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  568
tgggctgtga caaagtcaca                                                   20


<210>  569
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  569
ggccgagatg tctcgctccg                                                   20


<210>  570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  570
cagtaagtca acttcaatgt                                                   20


<210>  571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  571
actcacgctg gatagcctcc                                                   20


<210>  572
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  572
catactcatc tttttcagtg                                                   20


<210>  573
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  573
cacagcccaa gatagttaag                                                   20


<210>  574
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  574
ttcagacttg tctttcagca                                                   20


<210>  575
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  575
agtcacatgg ttcacacggc                                                   20


<210>  576
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  576
atactcatct ttttcagtgg                                                   20


<210>  577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  577
ggcatactca tctttttcag                                                   20


<210>  578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  578
acagcccaag atagttaagt                                                   20


<210>  579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  579
gctactctct ctttctggcc                                                   20


<210>  580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  580
tggagagaga attgaaaaag                                                   20


<210>  581
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  581
acttgtcttt cagcaaggac                                                   20


<210>  582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  582
gaagttgact tactgaagaa                                                   20


<210>  583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  583
ggccacggag cgagacatct                                                   20


<210>  584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  584
gcatactcat ctttttcagt                                                   20


<210>  585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  585
cgtgagtaaa cctgaatctt                                                   20


<210>  586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  586
ttaccccact taactatctt                                                   20


<210>  587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  587
ttggagtacc tgaggaatat                                                   20


<210>  588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  588
acccagacac atagcaattc                                                   20


<210>  589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  589
tttgactttc cattctctgc                                                   20


<210>  590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  590
ttcctgaatt gctatgtgtc                                                   20


<210>  591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  591
ctcaggtact ccaaagattc                                                   20


<210>  592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  592
cttaccccac ttaactatct                                                   20


<210>  593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  593
ctcgcgctac tctctctttc                                                   20


<210>  594
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  594
tcgatctatg aaaaagacag                                                   20


<210>  595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  595
gagacatgta agcagcatca                                                   20


<210>  596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  596
acatgtaagc agcatcatgg                                                   20


<210>  597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  597
gaagtcctag aatgagcgcc                                                   20


<210>  598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  598
gagcgcccgg tgtcccaagc                                                   20


<210>  599
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  599
agcgcccggt gtcccaagct                                                   20


<210>  600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  600
gcgcccggtg tcccaagctg                                                   20


<210>  601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  601
ctggggcgcg caccccagat                                                   20


<210>  602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  602
gggcgcgcac cccagatcgg                                                   20


<210>  603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  603
ggcgcgcacc ccagatcgga                                                   20


<210>  604
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  604
catcacgaga ctctaagaaa                                                   20


<210>  605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  605
taagaaaagg aaactgaaaa                                                   20


<210>  606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  606
aagaaaagga aactgaaaac                                                   20


<210>  607
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  607
gaaagtccct ctctctaacc                                                   20


<210>  608
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  608
ctaacctggc actgcgtcgc                                                   20


<210>  609
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  609
ctggcactgc gtcgctggct                                                   20


<210>  610
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  610
tgcgtcgctg gcttggagac                                                   20


<210>  611
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  611
gctggcttgg agacaggtga                                                   20


<210>  612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  612
gagacaggtg acggtccctg                                                   20


<210>  613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  613
agacaggtga cggtccctgc                                                   20


<210>  614
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  614
cctgcgggcc ttgtcctgat                                                   20


<210>  615
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  615
cgggccttgt cctgattggc                                                   20


<210>  616
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  616
gggccttgtc ctgattggct                                                   20


<210>  617
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  617
gggcacgcgt ttaatataag                                                   20


<210>  618
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  618
cacgcgttta atataagtgg                                                   20


<210>  619
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  619
tataagtgga ggcgtcgcgc                                                   20


<210>  620
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  620
aagtggaggc gtcgcgctgg                                                   20


<210>  621
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  621
agtggaggcg tcgcgctggc                                                   20


<210>  622
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  622
ttcctgaagc tgacagcatt                                                   20


<210>  623
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  623
tcctgaagct gacagcattc                                                   20


<210>  624
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  624
gcccgaatgc tgtcagcttc                                                   20


<210>  625
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  625
aaacgcgtgc ccagccaatc                                                   20


<210>  626
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  626
gtgcccagcc aatcaggaca                                                   20


<210>  627
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  627
ccaatcagga caaggcccgc                                                   20


<210>  628
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  628
caatcaggac aaggcccgca                                                   20


<210>  629
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  629
caagccagcg acgcagtgcc                                                   20


<210>  630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  630
cgcagtgcca ggttagagag                                                   20


<210>  631
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  631
gcagtgccag gttagagaga                                                   20


<210>  632
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  632
gagtctcgtg atgtttaaga                                                   20


<210>  633
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  633
taagaaggca tgcactagac                                                   20


<210>  634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  634
aagaaggcat gcactagact                                                   20


<210>  635
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  635
tgagtttgct gtctgtacat                                                   20


<210>  636
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  636
tacatcggcg ccctccgatc                                                   20


<210>  637
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  637
acatcggcgc cctccgatct                                                   20


<210>  638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  638
catcggcgcc ctccgatctg                                                   20


<210>  639
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  639
ctggggtgcg cgccccagct                                                   20


<210>  640
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  640
tggggtgcgc gccccagctt                                                   20


<210>  641
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  641
cgcgccccag cttgggacac                                                   20


<210>  642
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  642
gcgccccagc ttgggacacc                                                   20


<210>  643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  643
caagtcactt agcatctctg                                                   20


<210>  644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  644
acagaagttc tccttctgct                                                   20


<210>  645
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  645
attcaaagat cttaatcttc                                                   20


<210>  646
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  646
ttcaaagatc ttaatcttct                                                   20


<210>  647
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  647
ttttctcgaa tgaaaaatgc                                                   20


<210>  648
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  648
tgcaggtccg agcagttaac                                                   20


<210>  649
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  649
ggtccgagca gttaactggc                                                   20


<210>  650
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  650
gtccgagcag ttaactggct                                                   20


<210>  651
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  651
tccgagcagt taactggctg                                                   20


<210>  652
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  652
agcaagtcac ttagcatctc                                                   20


<210>  653
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  653
gcaagtcact tagcatctct                                                   20


<210>  654
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  654
tggggccagt ctgcaaagcg                                                   20


<210>  655
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  655
ggggccagtc tgcaaagcga                                                   20


<210>  656
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  656
gggccagtct gcaaagcgag                                                   20


<210>  657
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  657
ggccagtctg caaagcgagg                                                   20


<210>  658
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  658
ggacaccggg cgctcattct                                                   20


<210>  659
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  659
ggcgctcatt ctaggacttc                                                   20


<210>  660
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  660
ctcattctag gacttcaggc                                                   20


<210>  661
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  661
attctaggac ttcaggctgg                                                   20


<210>  662
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  662
ttcaggctgg aggcacatta                                                   20


<210>  663
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  663
tgccccctcg ctttgcagac                                                   20


<210>  664
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  664
gatgctaagt gacttgctaa                                                   20


<210>  665
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  665
gccccagcca gttaactgct                                                   20


<210>  666
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  666
gcatttttca ttcgagaaaa                                                   20


<210>  667
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  667
tttgaatgct acctagcaga                                                   20


<210>  668
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  668
ttctgtttat aactacagct                                                   20


<210>  669
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M targeting sequence

<400>  669
tctgtttata actacagctt                                                   20


<210>  670
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  670
agagaatgga aagtcaaatt t                                                 21


<210>  671
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  671
atggacatga tcttctttat a                                                 21


<210>  672
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  672
tggacatgat cttctttata a                                                 21


<210>  673
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  673
ggacatgatc ttctttataa t                                                 21


<210>  674
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  674
tgacaggatt attggaaatt t                                                 21


<210>  675
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  675
ttgtggttaa tctggtttat t                                                 21


<210>  676
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  676
tgtggttaat ctggtttatt t                                                 21


<210>  677
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  677
gcagagaatg gaaagtcaaa t                                                 21


<210>  678
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  678
cagagaatgg aaagtcaaat t                                                 21


<210>  679
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  679
gagaatggaa agtcaaattt c                                                 21


<210>  680
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  680
gtcacagccc aagatagtta a                                                 21


<210>  681
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  681
tgcttataca cttacacttt a                                                 21


<210>  682
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  682
gcttatacac ttacacttta t                                                 21


<210>  683
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  683
cttatacact tacactttat g                                                 21


<210>  684
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  684
acatggacat gatcttcttt a                                                 21


<210>  685
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  685
catggacatg atcttcttta t                                                 21


<210>  686
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  686
atcaacatct tggtcagatt t                                                 21


<210>  687
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  687
cttgcactca aagcttgtta a                                                 21


<210>  688
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  688
agttaagcgt gcataagtta a                                                 21


<210>  689
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  689
gcataagtta acttccaatt t                                                 21


<210>  690
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  690
tacatactct gcttagaatt t                                                 21


<210>  691
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  691
acatactctg cttagaattt g                                                 21


<210>  692
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  692
ttgacaggat tattggaaat t                                                 21


<210>  693
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  693
gacaggatta ttggaaattt g                                                 21


<210>  694
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  694
taaggcatgg ttgtggttaa t                                                 21


<210>  695
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  695
gttgtggtta atctggttta t                                                 21


<210>  696
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  696
gttccacaag ttaaataaat c                                                 21


<210>  697
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  697
tccagcgtac tccaaagatt c                                                 21


<210>  698
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  698
tactccaaag attcaggttt a                                                 21


<210>  699
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  699
actccaaaga ttcaggttta c                                                 21


<210>  700
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  700
cacgtcatcc agcagagaat g                                                 21


<210>  701
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  701
ggtttcatcc atccgacatt g                                                 21


<210>  702
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  702
ccgacattga agttgactta c                                                 21


<210>  703
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  703
tgaagaatgg agagagaatt g                                                 21


<210>  704
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  704
gagcattcag acttgtcttt c                                                 21


<210>  705
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  705
ttcagcaagg actggtcttt c                                                 21


<210>  706
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  706
gcaaggactg gtctttctat c                                                 21


<210>  707
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  707
cgtgtgaacc atgtgacttt g                                                 21


<210>  708
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  708
ctttgtcaca gcccaagata g                                                 21


<210>  709
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  709
tcacagccca agatagttaa g                                                 21


<210>  710
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  710
agtgggatcg agacatgtaa g                                                 21


<210>  711
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  711
aggtttgaag atgccgcatt t                                                 21


<210>  712
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  712
ggtttgaaga tgccgcattt g                                                 21


<210>  713
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  713
ttgatatgct tatacactta c                                                 21


<210>  714
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  714
tgagtgctgt ctccatgttt g                                                 21


<210>  715
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  715
tgtctccatg tttgatgtat c                                                 21


<210>  716
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  716
tcaacatctt ggtcagattt g                                                 21


<210>  717
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  717
tcagatttga actcttcaat c                                                 21


<210>  718
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  718
ttcaatctct tgcactcaaa g                                                 21


<210>  719
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  719
ttgcactcaa agcttgttaa g                                                 21


<210>  720
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  720
actcaaagct tgttaagata g                                                 21


<210>  721
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  721
agatagttaa gcgtgcataa g                                                 21


<210>  722
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  722
tgcataagtt aacttccaat t                                                 21


<210>  723
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  723
gttaacttcc aatttacata c                                                 21


<210>  724
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  724
attgacagga ttattggaaa t                                                 21


<210>  725
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  725
gtaaggcatg gttgtggtta a                                                 21


<210>  726
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  726
ggttgtggtt aatctggttt a                                                 21


<210>  727
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  727
ttcctgaagc tgacagcatt c                                                 21


<210>  728
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  728
gctatccagc gtactccaaa g                                                 21


<210>  729
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  729
catccagcag agaatggaaa g                                                 21


<210>  730
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  730
caaatttcct gaattgctat g                                                 21


<210>  731
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  731
attgctatgt gtctgggttt c                                                 21


<210>  732
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  732
gaagatgccg catttggatt g                                                 21


<210>  733
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  733
caatttacat actctgctta g                                                 21


<210>  734
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  734
tatccagcgt actccaaaga t                                                 21


<210>  735
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  735
atccagcgta ctccaaagat t                                                 21


<210>  736
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  736
ctccaaagat tcaggtttac t                                                 21


<210>  737
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  737
tgctatgtgt ctgggtttca t                                                 21


<210>  738
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  738
tttcatccat ccgacattga a                                                 21


<210>  739
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  739
gaagttgact tactgaagaa t                                                 21


<210>  740
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  740
gaagaatgga gagagaattg a                                                 21


<210>  741
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  741
agaatggaga gagaattgaa a                                                 21


<210>  742
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  742
cagcaaggac tggtctttct a                                                 21


<210>  743
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  743
agcaaggact ggtctttcta t                                                 21


<210>  744
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  744
actttgtcac agcccaagat a                                                 21


<210>  745
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  745
ttgtcacagc ccaagatagt t                                                 21


<210>  746
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  746
tgtcacagcc caagatagtt a                                                 21


<210>  747
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  747
cacagcccaa gatagttaag t                                                 21


<210>  748
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  748
gcagcatcat ggaggtttga a                                                 21


<210>  749
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  749
ccgcatttgg attggatgaa t                                                 21


<210>  750
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  750
ttgagtgctg tctccatgtt t                                                 21


<210>  751
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  751
agtgctgtct ccatgtttga t                                                 21


<210>  752
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  752
ctgtctccat gtttgatgta t                                                 21


<210>  753
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  753
tctaggaggg ctggcaactt a                                                 21


<210>  754
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  754
caacatcttg gtcagatttg a                                                 21


<210>  755
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  755
gtcagatttg aactcttcaa t                                                 21


<210>  756
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  756
tcttgcactc aaagcttgtt a                                                 21


<210>  757
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  757
tgcactcaaa gcttgttaag a                                                 21


<210>  758
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  758
gcactcaaag cttgttaaga t                                                 21


<210>  759
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  759
cactcaaagc ttgttaagat a                                                 21


<210>  760
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  760
tcaaagcttg ttaagatagt t                                                 21


<210>  761
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  761
caaagcttgt taagatagtt a                                                 21


<210>  762
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  762
gatagttaag cgtgcataag t                                                 21


<210>  763
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  763
atagttaagc gtgcataagt t                                                 21


<210>  764
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  764
tagttaagcg tgcataagtt a                                                 21


<210>  765
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  765
ttaagcgtgc ataagttaac t                                                 21


<210>  766
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  766
taagcgtgca taagttaact t                                                 21


<210>  767
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  767
atttacatac tctgcttaga a                                                 21


<210>  768
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  768
tttacatact ctgcttagaa t                                                 21


<210>  769
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  769
acaggattat tggaaatttg t                                                 21


<210>  770
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  770
caggattatt ggaaatttgt t                                                 21


<210>  771
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  771
aggcatggtt gtggttaatc t                                                 21


<210>  772
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  772
cagcagagaa tggaaagtca a                                                 21


<210>  773
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  773
tccgacattg aagttgactt a                                                 21


<210>  774
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  774
ctggtctttc tatctcttgt a                                                 21


<210>  775
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  775
ccgtgtgaac catgtgactt t                                                 21


<210>  776
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  776
cccaagatag ttaagtggga t                                                 21


<210>  777
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  777
ggttgctcca caggtagctc t                                                 21


<210>  778
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  778
gctccacagg tagctctagg a                                                 21


<210>  779
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  779
gggagcagag aattctctta t                                                 21


<210>  780
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  780
ggagcagaga attctcttat c                                                 21


<210>  781
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  781
gagcagagaa ttctcttatc c                                                 21


<210>  782
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  782
gagaattctc ttatccaaca t                                                 21


<210>  783
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  783
gaattctctt atccaacatc a                                                 21


<210>  784
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  784
aagtggagca ttcagacttg t                                                 21


<210>  785
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  785
aaggactggt ctttctatct c                                                 21


<210>  786
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  786
aagcttgtta agatagttaa g                                                 21


<210>  787
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  787
aagcgtgcat aagttaactt c                                                 21


<210>  788
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  788
aagatgccgc atttggattg g                                                 21


<210>  789
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  789
aagaatggag agagaattga a                                                 21


<210>  790
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  790
aacatcaaca tcttggtcag a                                                 21


<210>  791
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  791
aaggcatggt tgtggttaat c                                                 21


<210>  792
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  792
aagcagcatc atggaggttt g                                                 21


<210>  793
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  793
aagatgagta tgcctgccgt g                                                 21


<210>  794
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  794
aagttgactt actgaagaat g                                                 21


<210>  795
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  795
aagatagtta agcgtgcata a                                                 21


<210>  796
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  796
aacttccaat ttacatactc t                                                 21


<210>  797
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  797
aacatcttgg tcagatttga a                                                 21


<210>  798
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  798
aactcttcaa tctcttgcac t                                                 21


<210>  799
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  799
aatttcctga attgctatgt g                                                 21


<210>  800
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  800
aatggaaagt caaatttcct g                                                 21


<210>  801
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  801
aaccatgtga ctttgtcaca g                                                 21


<210>  802
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  802
aattgacagg attattggaa a                                                 21


<210>  803
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  803
aattctctta tccaacatca a                                                 21


<210>  804
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  804
aaagtggagc attcagactt g                                                 21


<210>  805
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  805
aaagtcaaat ttcctgaatt g                                                 21


<210>  806
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  806
gttgctccac aggtagctct a                                                 21


<210>  807
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target B2M sequences complement

<400>  807
aatttacata ctctgcttag a                                                 21


<210>  808
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M shRNA

<400>  808
gttaacttcc aatttacata ccgaagtatg taaattggaa gttaac                      46


<210>  809
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  809
cttcttcctt ccctattaaa a                                                 21


<210>  810
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  810
tctcactcca tgaggtattt c                                                 21


<210>  811
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  811
ctctcactcc atgaggtatt t                                                 21


<210>  812
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  812
gaggaggaag agctcagata g                                                 21


<210>  813
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  813
gctctcactc catgaggtat t                                                 21


<210>  814
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  814
aggattacat cgccctgaaa g                                                 21


<210>  815
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  815
acaccgtcca gaggatgtat g                                                 21


<210>  816
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  816
agggtccttc ttcctggata c                                                 21


<210>  817
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  817
cctacgacgg caaggattac a                                                 21


<210>  818
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  818
tcactccatg aggtatttct t                                                 21


<210>  819
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  819
ctacgacggc aaggattaca t                                                 21


<210>  820
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  820
ctcactccat gaggtatttc t                                                 21


<210>  821
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  821
ggaggaagag ctcagataga a                                                 21


<210>  822
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  822
cacaccgtcc agaggatgta t                                                 21


<210>  823
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  823
cacgctgtct ctgaccatga a                                                 21


<210>  824
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  824
ctggacagga gcagagatac a                                                 21


<210>  825
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  825
tggaggagga agagctcaga t                                                 21


<210>  826
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  826
ggctctcact ccatgaggta t                                                 21


<210>  827
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  827
catctctgtc tcaacttcat g                                                 21


<210>  828
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  828
tacgacggca aggattacat c                                                 21


<210>  829
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  829
ggattacatc gccctgaaag a                                                 21


<210>  830
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  830
gattacatcg ccctgaaaga g                                                 21


<210>  831
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  831
ctcagaccac caagcacaag t                                                 21


<210>  832
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  832
tcacaccgtc cagaggatgt a                                                 21


<210>  833
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  833
actccatgag gtatttcttc a                                                 21


<210>  834
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  834
cactccatga ggtatttctt c                                                 21


<210>  835
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  835
ccatgaggta tttcttcaca t                                                 21


<210>  836
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  836
acttcttcct tccctattaa a                                                 21


<210>  837
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  837
gtgtctctca cagcttgtaa a                                                 21


<210>  838
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  838
ctgtgttcgt gtaggcataa t                                                 21


<210>  839
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  839
tgtgttcgtg taggcataat g                                                 21


<210>  840
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  840
taacttcttc cttccctatt a                                                 21


<210>  841
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  841
tctggacagg agcagagata c                                                 21


<210>  842
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  842
ttgctggcct ggttctcttt g                                                 21


<210>  843
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  843
tgtctctcac agcttgtaaa g                                                 21


<210>  844
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  844
acttgaagaa ccctgacttt g                                                 21


<210>  845
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  845
gaagaaccct gactttgttt c                                                 21


<210>  846
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  846
tctgtgttcg tgtaggcata a                                                 21


<210>  847
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  847
catggtgcac tgagctgtaa c                                                 21


<210>  848
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  848
gtaacttctt ccttccctat t                                                 21


<210>  849
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  849
catgtgcagc atgagggttt g                                                 21


<210>  850
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  850
ttgttcctgc ccttcccttt g                                                 21


<210>  851
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  851
acccagttct cactcccatt g                                                 21


<210>  852
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  852
gggtttccag agaagccaat c                                                 21


<210>  853
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  853
ttctccctct cccaacctat g                                                 21


<210>  854
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  854
gtctctcaca gcttgtaaag t                                                 21


<210>  855
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  855
tgtgtctctc acagcttgta a                                                 21


<210>  856
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  856
gaggaagagc tcagatagaa a                                                 21


<210>  857
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  857
tgaagaaccc tgactttgtt t                                                 21


<210>  858
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  858
ttgaagaacc ctgactttgt t                                                 21


<210>  859
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  859
gtgttcgtgt aggcataatg t                                                 21


<210>  860
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  860
tggtgcactg agctgtaact t                                                 21


<210>  861
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  861
ctccctctcc caacctatgt a                                                 21


<210>  862
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  862
aggaggaaga gctcagatag a                                                 21


<210>  863
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  863
acctatgtag ggtccttctt c                                                 21


<210>  864
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  864
gggtccttct tcctggatac t                                                 21


<210>  865
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  865
ggtccttctt cctggatact c                                                 21


<210>  866
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  866
gtccttcttc ctggatactc a                                                 21


<210>  867
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  867
aagccaatca gtgtcgtcgc g                                                 21


<210>  868
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  868
aagaggacct gcgctcttgg a                                                 21


<210>  869
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  869
aagtgtgaga cagctgcctt g                                                 21


<210>  870
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  870
aaggcacctg catgtgtctg t                                                 21


<210>  871
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  871
aatcatcttt cctgttccag a                                                 21


<210>  872
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  872
aaaggcacct gcatgtgtct g                                                 21


<210>  873
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  873
aaagaggacc tgcgctcttg g                                                 21


<210>  874
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  874
aaacgcatat gactcaccac g                                                 21


<210>  875
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  875
ggaagagctc agatagaaa                                                    19


<210>  876
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  876
gggagacacg gaaagtgaa                                                    19


<210>  877
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  877
cacctgccat gtgcagcatg a                                                 21


<210>  878
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  878
ggagatcaca ctgacctggc a                                                 21


<210>  879
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  879
ggattacatc gccctgaaag                                                   20


<210>  880
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  880
gcaggagggt ccggagtatt                                                   20


<210>  881
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  881
ggacggggag acacggaaag                                                   20


<210>  882
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  882
gaaagtgaag gcccactca                                                    19


<210>  883
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  883
gatacctgga gaacgggaag                                                   20


<210>  884
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  884
gctgtggtgg tgccttctgg                                                   20


<210>  885
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  885
gctactacaa ccagagcgag                                                   20


<210>  886
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  886
gtggctccgc agatacctg                                                    19


<210>  887
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  887
gccaatcagt gtcgtcgcg                                                    19


<210>  888
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  888
gaggacctgc gctcttgga                                                    19


<210>  889
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  889
gtgtgagaca gctgccttg                                                    19


<210>  890
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  890
ggcacctgca tgtgtctgt                                                    19


<210>  891
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  891
tcatctttcc tgttccaga                                                    19


<210>  892
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  892
aggcacctgc atgtgtctg                                                    19


<210>  893
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  893
agaggacctg cgctcttgg                                                    19


<210>  894
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target HLA sequences complement

<400>  894
acgcatatga ctcaccacg                                                    19


<210>  895
<211>  2
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' Flank Sequence

<400>  895
gg                                                                       2


<210>  896
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' Flank Sequence

<400>  896
acaccauguu gccagucucu agg                                               23


<210>  897
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' Flank Sequence

<400>  897
ugauagcaau gucagcagug ccu                                               23


<210>  898
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' Flank Sequence

<400>  898
uauugcuguu gacagugagc gac                                               23


<210>  899
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' Flank Sequence

<400>  899
uggcgucugg cccaaccaca c                                                 21


<210>  900
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' Flank Sequence

<400>  900
guaagguuga ccauacucua c                                                 21


<210>  901
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  901
cgaa                                                                     4


<210>  902
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  902
uucaaga                                                                  7


<210>  903
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  903
auauuca                                                                  7


<210>  904
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  904
ugugcuguc                                                                9


<210>  905
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  905
cucgag                                                                   6


<210>  906
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  906
cuuccuguca ga                                                           12


<210>  907
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  907
cuucccuuug ucaga                                                        15


<210>  908
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  908
guguuauucu ug                                                           12


<210>  909
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  909
gugucuuaau ug                                                           12


<210>  910
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  910
guguuagucu ug                                                           12


<210>  911
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  911
ucaagag                                                                  7


<210>  912
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  912
ggacauccag gg                                                           12


<210>  913
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  913
gugaagccac agaug                                                        15


<210>  914
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop Region Sequence

<400>  914
gauucuaaaa                                                              10


<210>  915
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 Blocker 4

<400>  915

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Cys Leu Gly Val Leu Leu Tyr Asn Trp Phe 
        115                 120                 125             


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        195                 200                 205             


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Tyr Gly Ser Gln Ser Ser Lys 
            260                 265                 270         


Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu Leu Val Val Ser 
        275                 280                 285             


Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr 
    290                 295                 300                 


Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln 
305                 310                 315                 320 


Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly Ile Leu Val Ala 
                325                 330                 335     


Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg 
            340                 345                 350         


His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp 
        355                 360                 365             


Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly 
    370                 375                 380                 


Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu 
385                 390                 395                 400 


Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp 
                405                 410                 415     


Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu 
            420                 425                 430         


Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro 
        435                 440                 445             


Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp 
    450                 455                 460                 


Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val 
465                 470                 475                 480 


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu 
                485                 490                 495     


Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr 
            500                 505                 510         


Ala Thr Leu Ala Ile His 
        515             


<210>  916
<211>  1554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-A*11 Blocker 4

<400>  916
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtgaag tgcagctggt ggaaagcggc ggaggcctgg tgcagcctgg cggcagcctg      120

agactgtctt gcgccgccag cggcttcacc ttcagcagct actggatgca ctgggtccgc      180

caggcccctg gcaagggact ggtctgggtg tctcgaatca acagcgacgg cagcagcacc      240

agctacgccg acagcgtgaa gggccggttc accatcagcc gggacaacgc caagaacacc      300

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgttgtttg      360

ggtgttttat tatacaactg gttcgacccc tggggccagg gaaccctggt caccgtgtcc      420

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      480

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      540

tgccgggcaa gtcagagcat tagcagctat ttaaattggt atcagcagaa accagggaaa      600

gcccctaagc tcctgatcta tgctgcatcc agtttgcaaa gtggggtccc atcaaggttc      660

agtggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      720

tttgcaactt actactgtca acagagttac agtacccctc tcactttcgg cggcggaaca      780

aaggtggaga tcaagtacgg ctcacagagc tccaaaccct acctgctgac tcaccccagt      840

gaccccctgg agctcgtggt ctcaggaccg tctgggggcc ccagctcccc gacaacaggc      900

cccacctcca catctggccc tgaggaccag cccctcaccc ccaccgggtc ggatccccag      960

agtggtctgg gaaggcacct gggggttgtg atcggcatct tggtggccgt catcctactg     1020

ctcctcctcc tcctcctcct cttcctcatc ctccgacatc gacgtcaggg caaacactgg     1080

acatcgaccc agagaaaggc tgatttccaa catcctgcag gggctgtggg gccagagccc     1140

acagacagag gcctgcagtg gaggtccagc ccagctgccg atgcccagga agaaaacctc     1200

tatgctgccg tgaagcacac acagcctgag gatggggtgg agatggacac tcggagccca     1260

cacgatgaag acccccaggc agtgacgtat gccgaggtga aacactccag acctaggaga     1320

gaaatggcct ctcctccttc cccactgtct ggggaattcc tggacacaaa ggacagacag     1380

gcggaagagg acaggcagat ggacactgag gctgctgcat ctgaagcccc ccaggatgtg     1440

acctacgccc agctgcacag cttgaccctc agacgggagg caactgagcc tcctccatcc     1500

caggaagggc cctctccagc tgtgcccagc atctacgcca ctctggccat ccac           1554


<210>  917
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  917
atggatatga gagtgcctgc ccagctgctc ggactgctcc ttctgtggtt gagaggagct       60

cggtgc                                                                  66


<210>  918
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  918

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Arg Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  919
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  919

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Arg Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


