                         SEQUENCE LISTING

<110>  CODA Biotherapeutics, Inc.
       Lau, Anthony
       Keifer, Orion P.
       Makinson, Stefanie
       Naka, Alexander
 
<120>  COMPOSITIONS AND METHODS FOR NEUROLOGICAL DISEASES

<130>  SWCH-034/01WO 322917-2461

<150>  US 63/068,890
<151>  2020-08-21

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  1835
<212>  DNA
<213>  Homo sapiens

<400>  1
caacagacac gctggagttt aacaaacagc aatactcttc gcgctcctga aaagcaggtc       60

tggacgctct ccgtggtgct gaaacgcctc gcagccgccg ctgtccgtgg tatctacgac      120

cccctcgctc caatttcccc tggggctctc cctccgcgcc cctgttcccc gcctcccttt      180

aacatctgga ttattttttg caatagcgct ttctggtttt gtaagtgcca atttgaaaca      240

tttttgcccc cataactcgt ggactacaaa gcacaaggac ctgaaaaatg tacagcttca      300

atactcttcg actctacctt tgggagacca ttgtattctt cagccttgct gcttctaagg      360

aggctgaagc tgctcgctcc gcacccaagc ctatgtcacc ctcggatttc ctggataagc      420

taatggggag aacctccgga tatgatgcca ggatcaggcc caattttaaa ggtcccccag      480

tgaacgtgag ctgcaacatt ttcatcaaca gctttggttc cattgctgag acaaccatgg      540

actatagggt caacatcttc ctgcggcagc aatggaacga cccccgcctg gcctataatg      600

aataccctga cgactctctg gacctggacc catccatgct ggactccatc tggaaacctg      660

acctgttctt tgccaacgag aagggggccc acttccatga gatcaccaca gacaacaaat      720

tgctaaggat ctcccggaat gggaatgtcc tctacagcat cagaatcacc ctgacactgg      780

cctgccccat ggacttgaag aatttcccca tggatgtcca gacatgtatc atgcaactgg      840

aaagctttgg atatacgatg aatgacctca tctttgagtg gcaggaacag ggagccgtgc      900

aggtagcaga tggactaact ctgccccagt ttatcttgaa ggaagagaag gacttgagat      960

actgcaccaa gcactacaac acaggtaaat tcacctgcat tgaggcccgg ttccacctgg     1020

agcggcagat gggttactac ctgattcaga tgtatattcc cagcctgctc attgtcatcc     1080

tctcatggat ctccttctgg atcaacatgg atgctgcacc tgctcgtgtg ggcctaggca     1140

tcaccactgt gctcaccatg accacccaga gctccggctc tcgagcatct ctgcccaagg     1200

tgtcctatgt gaaagccatt gacatttgga tggcagtttg cctgctcttt gtgttctcag     1260

ccctattaga atatgctgcc gttaactttg tgtctcggca acataaggag ctgctccgat     1320

tcaggaggaa gcggagacat cacaagagcc ccatgttgaa tctattccag gaggatgaag     1380

ctggagaagg ccgctttaac ttctctgcct atgggatggg cccagcctgt ctacaggcca     1440

aggatggcat ctcagtcaag ggcgccaaca acagtaacac caccaacccc cctcctgcac     1500

catctaagtc cccagaggag atgcgaaaac tcttcatcca gagggccaag aagatcgaca     1560

aaatatcccg cattggcttc cccatggcct tcctcatttt caacatgttc tactggatca     1620

tctacaagat tgtccgtaga gaggacgtcc acaaccagtg aagggtctga aaggttgggg     1680

gaggctggga gaggggaacg tgggaatagc acaggaatct gagagactaa ggaagagaag     1740

gggaacggag ggagggggca cacttacaca actctctctg caatatgtgc aatagcaaaa     1800

tgcagtgatg catgaatttt aaaaaaaaaa aaaaa                                1835


<210>  2
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Tyr Ser Phe Asn Thr Leu Arg Leu Tyr Leu Trp Glu Thr Ile Val 
1               5                   10                  15      


Phe Phe Ser Leu Ala Ala Ser Lys Glu Ala Glu Ala Ala Arg Ser Ala 
            20                  25                  30          


Pro Lys Pro Met Ser Pro Ser Asp Phe Leu Asp Lys Leu Met Gly Arg 
        35                  40                  45              


Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn Phe Lys Gly Pro Pro 
    50                  55                  60                  


Val Asn Val Ser Cys Asn Ile Phe Ile Asn Ser Phe Gly Ser Ile Ala 
65                  70                  75                  80  


Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe Leu Arg Gln Gln Trp 
                85                  90                  95      


Asn Asp Pro Arg Leu Ala Tyr Asn Glu Tyr Pro Asp Asp Ser Leu Asp 
            100                 105                 110         


Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys Pro Asp Leu Phe Phe 
        115                 120                 125             


Ala Asn Glu Lys Gly Ala His Phe His Glu Ile Thr Thr Asp Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Ser Arg Asn Gly Asn Val Leu Tyr Ser Ile Arg Ile 
145                 150                 155                 160 


Thr Leu Thr Leu Ala Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
                165                 170                 175     


Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe Gly Tyr Thr Met Asn 
            180                 185                 190         


Asp Leu Ile Phe Glu Trp Gln Glu Gln Gly Ala Val Gln Val Ala Asp 
        195                 200                 205             


Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys Glu Glu Lys Asp Leu Arg 
    210                 215                 220                 


Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe Thr Cys Ile Glu Ala 
225                 230                 235                 240 


Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr 
                245                 250                 255     


Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile 
            260                 265                 270         


Asn Met Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val 
        275                 280                 285             


Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys 
    290                 295                 300                 


Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu 
305                 310                 315                 320 


Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser 
                325                 330                 335     


Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His 
            340                 345                 350         


Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly 
        355                 360                 365             


Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala 
    370                 375                 380                 


Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn 
385                 390                 395                 400 


Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe 
                405                 410                 415     


Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro 
            420                 425                 430         


Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile 
        435                 440                 445             


Val Arg Arg Glu Asp Val His Asn Gln 
    450                 455         


<210>  3
<211>  3356
<212>  DNA
<213>  Homo sapiens

<400>  3
tccttaaagg cgcgcgagcc gagcggcgag gtgcctctgt ggccgcaggc gcaggcccgg       60

gcgacagccg agacgtggag cgcgccggct cgctgcagct ccgggactca acatgcgctg      120

ctcgccggga ggcgtctggc tggcgctggc cgcgtcgctc ctgcacgtgt ccctgcaagg      180

cgagttccag aggaagcttt acaaggagct ggtcaagaac tacaatccct tggagaggcc      240

cgtggccaat gactcgcaac cactcaccgt ctacttctcc ctgagcctcc tgcagatcat      300

ggacgtggat gagaagaacc aagttttaac caccaacatt tggctgcaaa tgtcttggac      360

agatcactat ttacagtgga atgtgtcaga atatccaggg gtgaagactg ttcgtttccc      420

agatggccag atttggaaac cagacattct tctctataac agtgctgatg agcgctttga      480

cgccacattc cacactaacg tgttggtgaa ttcttctggg cattgccagt acctgcctcc      540

aggcatattc aagagttcct gctacatcga tgtacgctgg tttccctttg atgtgcagca      600

ctgcaaactg aagtttgggt cctggtctta cggaggctgg tccttggatc tgcagatgca      660

ggaggcagat atcagtggct atatccccaa tggagaatgg gacctagtgg gaatccccgg      720

caagaggagt gaaaggttct atgagtgctg caaagagccc taccccgatg tcaccttcac      780

agtgaccatg cgccgcagga cgctctacta tggcctcaac ctgctgatcc cctgtgtgct      840

catctccgcc ctcgccctgc tggtgttcct gcttcctgca gattccgggg agaagatttc      900

cctggggata acagtcttac tctctcttac cgtcttcatg ctgctcgtgg ctgagatcat      960

gcccgcaaca tccgattcgg taccattgat agcccagtac ttcgccagca ccatgatcat     1020

cgtgggcctc tcggtggtgg tgacagtgat cgtgctgcag taccaccacc acgaccccga     1080

cgggggcaag atgcccaagt ggaccagagt catccttctg aactggtgcg cgtggttcct     1140

gcgaatgaag aggcccgggg aggacaaggt gcgcccggcc tgccagcaca agcagcggcg     1200

ctgcagcctg gccagtgtgg agatgagcgc cgtggcgccg ccgcccgcca gcaacgggaa     1260

cctgctgtac atcggcttcc gcggcctgga cggcgtgcac tgtgtcccga cccccgactc     1320

tggggtagtg tgtggccgca tggcctgctc ccccacgcac gatgagcacc tcctgcacgg     1380

cgggcaaccc cccgaggggg acccggactt ggccaagatc ctggaggagg tccgctacat     1440

tgccaaccgc ttccgctgcc aggacgaaag cgaggcggtc tgcagcgagt ggaagttcgc     1500

cgcctgtgtg gtggaccgcc tgtgcctcat ggccttctcg gtcttcacca tcatctgcac     1560

catcggcatc ctgatgtcgg ctcccaactt cgtggaggcc gtgtccaaag actttgcgta     1620

accacgcctg gttctgtaca tgtggaaaac tcacagatgg gcaaggcctt tggcttggcg     1680

agatttgggg gtgctaatcc aggacagcat tacacgccac aactccagtg ttcccttctg     1740

gctgtcagtc gtgttgctta cggtttcttt gttactttag gtagtagaat ctcagcactt     1800

tgtttcatat tctcagatgg gctgatagat atccttggca catccgtacc atcggtcagc     1860

agggccactg agtagtcatt ttgcccatta gcccactgcc tggaaagccc ttcggagagc     1920

tccccatggc tcctcaccac cgagacagtt ggttttgcat gtctgcatga aggtctacct     1980

gaaaattcaa catttgcttt ttgcttgtgt acaaacccag attgaagcta aaataaacca     2040

gactcactaa atcctttcca ataattgact ggtggaagga aaacaaaaaa caaaaactaa     2100

aaacctctta gcttttctgc aattcaactt tttattttta tttttatttc tatcaaagac     2160

ggtagagaga aacagcttga tgctgtttct acattaaaaa aaaaaaaaaa agacagactg     2220

ttggtcttac taaggatgtt tttaccagcc tgcctgactt ctgcaaacct accctgtcaa     2280

ggagatcaaa gggacgcagg tttctgttta ttctgaacaa gggccaggcc ccgcggagtg     2340

tctttggtgg atcccagata actcctaggt gctgctctca gacactgagg agttgagcaa     2400

atctgttcta ttctgcagaa cccacaggac aaataagagt tctactagaa ttaacagccc     2460

aaaagaatag ctacagctaa gtgaagccac ttacgtgggc tttaaaaaaa taatgtgtta     2520

gctgattcac atgcactgga gttaattagt cttagaaatg tgtgcatcca tacaaatgca     2580

caacataaag tgaacatatt cctaggccct ttctgcctgt gtcagggcca ggaagtagag     2640

gctgggaact cttctggtcc ccagtatggc aggcgccagg gaggggatgg tgtggcccat     2700

cccttctctg gatacctggc cagtggcagg cagcagggag gagctggccg accctcagtg     2760

actgacaagc cagcaattct gagttctggc ctttgggagt ctgcctgctc caagccagtc     2820

caccccagct gcagccccaa aagctggctc aaagtccttg ggtggattca ctggagatgg     2880

gcaacttaaa acaagagaaa ctttaatttt taaacctaag tgatgataca gctcttccct     2940

tagattatcg cccaggctgg agtgcagtgg catgatctca gctcactgca agctccacct     3000

cctgggttca tgccattctc ctgcctcagc ctccccccga gtaactggga atacaggcgc     3060

ccgccaccat gcctggctaa ttttttgtat ttttagtaga gatagggttt catcatgtta     3120

gccaggatgg tctcattctt attctttaat gagatcagag ggtaattcac caagaaagac     3180

ctctcctgtt ccattgtgtc atccaacaac tgctcagagc tcaaaattat agaaggcttc     3240

tgagccccta gagattttta atttgcttct aatccctgag gtgggaacat catgagggaa     3300

gatttgattt tcagagttaa ataaattgta tgtgcttttc cagccaaaaa aaaaaa         3356


<210>  4
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Thr Leu Tyr Tyr Gly Leu Asn Leu Leu Ile Pro 
225                 230                 235                 240 


Cys Val Leu Ile Ser Ala Leu Ala Leu Leu Val Phe Leu Leu Pro Ala 
                245                 250                 255     


Asp Ser Gly Glu Lys Ile Ser Leu Gly Ile Thr Val Leu Leu Ser Leu 
            260                 265                 270         


Thr Val Phe Met Leu Leu Val Ala Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Tyr Phe Ala Ser Thr Met Ile Ile Val 
    290                 295                 300                 


Gly Leu Ser Val Val Val Thr Val Ile Val Leu Gln Tyr His His His 
305                 310                 315                 320 


Asp Pro Asp Gly Gly Lys Met Pro Lys Trp Thr Arg Val Ile Leu Leu 
                325                 330                 335     


Asn Trp Cys Ala Trp Phe Leu Arg Met Lys Arg Pro Gly Glu Asp Lys 
            340                 345                 350         


Val Arg Pro Ala Cys Gln His Lys Gln Arg Arg Cys Ser Leu Ala Ser 
        355                 360                 365             


Val Glu Met Ser Ala Val Ala Pro Pro Pro Ala Ser Asn Gly Asn Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Phe Arg Gly Leu Asp Gly Val His Cys Val Pro Thr 
385                 390                 395                 400 


Pro Asp Ser Gly Val Val Cys Gly Arg Met Ala Cys Ser Pro Thr His 
                405                 410                 415     


Asp Glu His Leu Leu His Gly Gly Gln Pro Pro Glu Gly Asp Pro Asp 
            420                 425                 430         


Leu Ala Lys Ile Leu Glu Glu Val Arg Tyr Ile Ala Asn Arg Phe Arg 
        435                 440                 445             


Cys Gln Asp Glu Ser Glu Ala Val Cys Ser Glu Trp Lys Phe Ala Ala 
    450                 455                 460                 


Cys Val Val Asp Arg Leu Cys Leu Met Ala Phe Ser Val Phe Thr Ile 
465                 470                 475                 480 


Ile Cys Thr Ile Gly Ile Leu Met Ser Ala Pro Asn Phe Val Glu Ala 
                485                 490                 495     


Val Ser Lys Asp Phe Ala 
            500         


<210>  5
<211>  2343
<212>  DNA
<213>  Homo sapiens

<400>  5
ctctcagctg tcccctcccc tttcctcccg cctgaaacat gatccagctg aaggactgat       60

tgcaggaaaa cttggcagct ccccaacctt ggtggcccag ggagtgtgag gctgcagcct      120

cagaaggtgt gagcagtggc cacgagaggc aggctggctg ggacatgagg ttggcagagg      180

gcaggcaagc tggcccttgg tgggcctcgt cctgagcact cggaggcact cctatgcttg      240

gaaagctcgc tatgctgctg tgggtccagc aggcgctgct cgccttgctc ctccccacac      300

tcctggcaca gggagaagcc aggaggagcc gaaacaccac caggcccgct ctgctgaggc      360

tgtcggatta ccttttgacc aactacagga agggtgtgcg ccccgtgagg gactggagga      420

agccaaccac cgtatccatt gacgtcattg tctatgccat cctcaacgtg gatgagaaga      480

atcaggtgct gaccacctac atctggtacc ggcagtactg gactgatgag tttctccagt      540

ggaaccctga ggactttgac aacatcacca agttgtccat ccccacggac agcatctggg      600

tcccggacat tctcatcaat gagttcgtgg atgtggggaa gtctccaaat atcccgtacg      660

tgtatattcg gcatcaaggc gaagttcaga actacaagcc ccttcaggtg gtgactgcct      720

gtagcctcga catctacaac ttccccttcg atgtccagaa ctgctcgctg accttcacca      780

gttggctgca caccatccag gacatcaaca tctctttgtg gcgcttgcca gaaaaggtga      840

aatccgacag gagtgtcttc atgaaccagg gagagtggga gttgctgggg gtgctgccct      900

actttcggga gttcagcatg gaaagcagta actactatgc agaaatgaag ttctatgtgg      960

tcatccgccg gcggcccctc ttctatgtgg tcagcctgct actgcccagc atcttcctca     1020

tggtcatgga catcgtgggc ttctacctgc cccccaacag tggcgagagg gtctctttca     1080

agattacact cctcctgggc tactcggtct tcctgatcat cgtttctgac acgctgccgg     1140

ccactgccat cggcactcct ctcattggta aggcccctcc tggcagcaga gctcagtctg     1200

gtgagaaacc cgccccctcc cacctcctgc atgtgtctct tgcctctgcc ctgggctgca     1260

caggtgtcta ctttgtggtg tgcatggctc tgctggtgat aagtttggcc gagaccatct     1320

tcattgtgcg gctggtgcac aagcaagacc tgcagcagcc cgtgcctgct tggctgcgtc     1380

acctggttct ggagagaatc gcctggctac tttgcctgag ggagcagtca acttcccaga     1440

ggcccccagc cacctcccaa gccaccaaga ctgatgactg ctcagccatg ggaaaccact     1500

gcagccacat gggaggaccc caggacttcg agaagagccc gagggacaga tgtagccctc     1560

ccccaccacc tcgggaggcc tcgctggcgg tgtgtgggct gctgcaggag ctgtcctcca     1620

tccggcaatt cctggaaaag cgggatgaga tccgagaggt ggcccgagac tggctgcgcg     1680

tgggctccgt gctggacaag ctgctattcc acatttacct gctagcggtg ctggcctaca     1740

gcatcaccct ggttatgctc tggtccatct ggcagtacgc ttgagtgggt acagcccagt     1800

ggaggagggg gtacagtcct ggttaggtgg ggacagagga tttctgctta ggcccctcag     1860

gacccaggga atgccaggga cattttcaag acacagacaa agtcccgtgc cctgtttcca     1920

atgccaattc atctcagcaa tcacaagcca aggtctgaac ccttccacca aaaactgggt     1980

gttcaaggcc cttacaccct tgtcccaccc ccagcagctc accatggctt taaaacatgc     2040

tgtcttagat caggagaaac tcgggcactc cctaagtcca ctctagttgt ggacttttcc     2100

ccattgaccc tcacctgaat aagggacttt ggaattctgc ttctctttca caactttgct     2160

tttaggttga aggcaaaacc aactctctac tacacaggcc tgataactct gtacgaggct     2220

tctctaaccc ctagtgtctt ttttttcttc acctcacttg tggcagcttc cctgaacact     2280

catcccccat cagatgatgg gagtgggaag aataaaatgc agtgaaaccc taaaaaaaaa     2340

aaa                                                                   2343


<210>  6
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Gly Lys Leu Ala Met Leu Leu Trp Val Gln Gln Ala Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser 
            20                  25                  30          


Arg Asn Thr Thr Arg Pro Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu 
        35                  40                  45              


Thr Asn Tyr Arg Lys Gly Val Arg Pro Val Arg Asp Trp Arg Lys Pro 
    50                  55                  60                  


Thr Thr Val Ser Ile Asp Val Ile Val Tyr Ala Ile Leu Asn Val Asp 
65                  70                  75                  80  


Glu Lys Asn Gln Val Leu Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp 
                85                  90                  95      


Thr Asp Glu Phe Leu Gln Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr 
            100                 105                 110         


Lys Leu Ser Ile Pro Thr Asp Ser Ile Trp Val Pro Asp Ile Leu Ile 
        115                 120                 125             


Asn Glu Phe Val Asp Val Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr 
    130                 135                 140                 


Ile Arg His Gln Gly Glu Val Gln Asn Tyr Lys Pro Leu Gln Val Val 
145                 150                 155                 160 


Thr Ala Cys Ser Leu Asp Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn 
                165                 170                 175     


Cys Ser Leu Thr Phe Thr Ser Trp Leu His Thr Ile Gln Asp Ile Asn 
            180                 185                 190         


Ile Ser Leu Trp Arg Leu Pro Glu Lys Val Lys Ser Asp Arg Ser Val 
        195                 200                 205             


Phe Met Asn Gln Gly Glu Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe 
    210                 215                 220                 


Arg Glu Phe Ser Met Glu Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe 
225                 230                 235                 240 


Tyr Val Val Ile Arg Arg Arg Pro Leu Phe Tyr Val Val Ser Leu Leu 
                245                 250                 255     


Leu Pro Ser Ile Phe Leu Met Val Met Asp Ile Val Gly Phe Tyr Leu 
            260                 265                 270         


Pro Pro Asn Ser Gly Glu Arg Val Ser Phe Lys Ile Thr Leu Leu Leu 
        275                 280                 285             


Gly Tyr Ser Val Phe Leu Ile Ile Val Ser Asp Thr Leu Pro Ala Thr 
    290                 295                 300                 


Ala Ile Gly Thr Pro Leu Ile Gly Lys Ala Pro Pro Gly Ser Arg Ala 
305                 310                 315                 320 


Gln Ser Gly Glu Lys Pro Ala Pro Ser His Leu Leu His Val Ser Leu 
                325                 330                 335     


Ala Ser Ala Leu Gly Cys Thr Gly Val Tyr Phe Val Val Cys Met Ala 
            340                 345                 350         


Leu Leu Val Ile Ser Leu Ala Glu Thr Ile Phe Ile Val Arg Leu Val 
        355                 360                 365             


His Lys Gln Asp Leu Gln Gln Pro Val Pro Ala Trp Leu Arg His Leu 
    370                 375                 380                 


Val Leu Glu Arg Ile Ala Trp Leu Leu Cys Leu Arg Glu Gln Ser Thr 
385                 390                 395                 400 


Ser Gln Arg Pro Pro Ala Thr Ser Gln Ala Thr Lys Thr Asp Asp Cys 
                405                 410                 415     


Ser Ala Met Gly Asn His Cys Ser His Met Gly Gly Pro Gln Asp Phe 
            420                 425                 430         


Glu Lys Ser Pro Arg Asp Arg Cys Ser Pro Pro Pro Pro Pro Arg Glu 
        435                 440                 445             


Ala Ser Leu Ala Val Cys Gly Leu Leu Gln Glu Leu Ser Ser Ile Arg 
    450                 455                 460                 


Gln Phe Leu Glu Lys Arg Asp Glu Ile Arg Glu Val Ala Arg Asp Trp 
465                 470                 475                 480 


Leu Arg Val Gly Ser Val Leu Asp Lys Leu Leu Phe His Ile Tyr Leu 
                485                 490                 495     


Leu Ala Val Leu Ala Tyr Ser Ile Thr Leu Val Met Leu Trp Ser Ile 
            500                 505                 510         


Trp Gln Tyr Ala 
        515     


<210>  7
<211>  5723
<212>  DNA
<213>  Homo sapiens

<400>  7
gctccgggcc agcgcggcgg cggcggcggc ggcggcagca gcaggagcag ccccggctgc       60

gggtcgcgac ggcggcgggg cgccccctcc cccgtgccgg ggcgcggcgg agggatgtgg      120

ggccttgcgg gaggaaggct tttcggcatc ttctcggccc cggtgctggt ggctgtggtg      180

tgctgcgccc agagtgtgaa cgatcccggg aacatgtcct ttgtgaagga gacggtggac      240

aagctgttga aaggctacga cattcgccta agacccgact tcgggggtcc cccggtctgc      300

gtggggatga acatcgacat cgccagcatc gacatggttt ccgaagtcaa catggattat      360

accttaacca tgtattttca acaatattgg agagataaaa ggctcgccta ttctgggatc      420

cctctcaacc tcacgcttga caatcgagtg gctgaccagc tatgggtgcc cgacacatat      480

ttcttaaatg acaaaaagtc atttgtgcat ggagtgacag tgaaaaaccg catgatccgt      540

cttcaccctg atgggacagt gctgtatggg ctcagaatca ccacgacagc agcatgcatg      600

atggacctca ggagataccc cctggacgag cagaactgca ctctggaaat tgaaagctat      660

ggctacacca cggatgacat tgagttttac tggcgaggcg gggacaaggc tgttaccgga      720

gtggaaagga ttgagctccc gcagttctcc atcgtggagc accgtctggt ctcgaggaat      780

gttgtcttcg ccacaggtgc ctatcctcga ctgtcactga gctttcggtt gaagaggaac      840

attggatact tcattcttca gacttatatg ccctctatac tgataacgat tctgtcgtgg      900

gtgtccttct ggatcaatta tgatgcatct gctgctagag ttgccctcgg gatcacaact      960

gtgctgacaa tgacaaccat caacacccac cttcgggaga ccttgcccaa aatcccctat     1020

gtcaaagcca ttgacatgta ccttatgggc tgcttcgtct ttgtgttcct ggcccttctg     1080

gagtatgcct ttgtcaacta cattttcttt ggaagaggcc ctcaaaggca gaagaagctt     1140

gcagaaaaga cagccaaggc aaagaatgac cgttcaaaga gcgaaagcaa ccgggtggat     1200

gctcatggaa atattctgtt gacatcgctg gaagttcaca atgaaatgaa tgaggtctca     1260

ggcggcattg gcgataccag gaattcagca atatcctttg acaactcagg aatccagtac     1320

aggaaacaga gcatgcctcg agaagggcat gggcgattcc tgggggacag aagcctcccg     1380

cacaagaaga cccatctacg gaggaggtct tcacagctca aaattaaaat acctgatcta     1440

accgatgtga atgccataga cagatggtcc aggatcgtgt ttccattcac tttttctctt     1500

ttcaacttag tttactggct gtactatgtt aactgagtga ctgtacttga tttttcaaag     1560

acttcattta acactgagtg aaatattact ctgcctgtca agtttttata cctgtacaca     1620

cacagacaca caagcagaca cacacatata tacatacgca attgtatata tatgtgaact     1680

ttctcagcat atatataaaa tacacgtgta tatgaggatg tatgtgtata tgtttataca     1740

cacaggagtc agtgcccatg tgtatggaag acaaatacac atacatatat acattttgca     1800

gctatggaca atttaccaca ggatgcatat taaagaaagt catagttttt ttctttttta     1860

attgaaaggg acaagtatca tctaaatatt atgccttgag aatgagggcg tgaaacacaa     1920

tatcatcccc aaatgtgtct tgtattatca taagttagat gttttagttt aaaaatcaga     1980

aagacattct tagttaatct ttgaaaactc atacagtggt attgctagtt taaaatgagt     2040

cacttacttc atatcctctc gttcagttta gtaagcaaag gcttcttggc ttctctggtg     2100

atggggtttg ttttcatcgg gcatacgttt tctgcaatgg tttagtggct ggggtgagcc     2160

actggcagtg tgcttacctg ttgtctgaaa catagataga tcccacgttg atgtctgaac     2220

gaccgtcttt tgaaaactca tcgggagtga atggcatctc gttgtaagta ctctaatata     2280

cagtgtgtag tttgtttctg ttgttcactt ggagtggatc cagcttcact gtcatgtgcg     2340

aacacagtga cacgtttggc cagtgacatt tcaatcactg aaaatgtgct ctacatctcg     2400

tatggatttc taggcctgat atccaacaga aagcatagac gtctcaggtt attcgttact     2460

ctaaggtaaa accatctagg atgattttcc cccttgcagt tatgttatca ttcttataac     2520

attgtatgtt aatagaaaat atatttgcat aatatgcata tatatgtata tttaccaaga     2580

ttttgtttct tacgcttgct atcatggcag catgcgatgt catattttcc tttatgtgat     2640

gtaactactt tctgttatct agaaattaag attgaagcta aaacacttct actgttcaat     2700

ttcagaaact aagaatcatc ctcatgcctt tatttctgta tctgacatat ttcataagca     2760

catccaacta ctcctagact gactaggatt ctgcaggaac atgacccgta cacaccacgc     2820

gtcacccaac gacccatgac cgttctctga ggcaaaggag ggcaacctga cagcaaacac     2880

agtcactgtt ggttccttct gatccacagc ctcatcagta tttggacttt ttaaagctcg     2940

tagaaacaag acaaggtgca ccggtttcat agacgcaacc ttaacttact atttagatga     3000

gatctttcta aagaaaaaaa aaagagatga tatatttttt gtaaacaata tttctatcac     3060

aggcatccat aaactgaaat gactacagtt gtgcaaacag gtgtcacagt gaagttgagc     3120

atttggagaa aaaaataaaa agcaaaattt gcaggaagaa ctgctaaatt aatactttat     3180

cccaaaatgc cacgtatgcc tcaccctctc tgttctatcc aaaaccaagg accagagtgc     3240

tccaatggta ggccccagtt gtctcgatgt aggtagaggc accaccctcc ccgaggatgc     3300

gtgtggtgtg gactatcccc atgagctgac cactacttga tttttctttg gtggccgtaa     3360

caacctttaa tttgtgggca tctgcaacag ttcaaaaccc accatcagat aaaacataat     3420

ccacaaaatc tcacgctaga ggcaattacc tacttttaga cccttttccc tctttcattc     3480

ctatcttttt cctcctaatc gctgctctct ggttttattt tcatctggag actagccagg     3540

gatttctttg gctttggctt ttctctgacc attttttcca tgggtaacaa tgggggatcc     3600

taaaagttaa acagattggg aaaaaccttg ttaagtggcc ttatcattat tatcatgtta     3660

aagaaaaaaa atacatttgc aaagacctta tccctttcaa tacttcaggt atctttttct     3720

gtatccagta attaaaggtg tgaggtccac atgcagaaga gggaccccaa aatgtaaatg     3780

gatgtggaca aaaacagtca atggtctatt taagtgtata atttatacta ttcagaactg     3840

tgacattaat tctttctggg agaaaagtga tttaaaactt ttttgatgca tagttgaggt     3900

acccaaatat caaaggcaga gaccccatgg ggctccaaag agctgcagtc tccttcccaa     3960

ggttttctgg atataaattt gcatggtata gtcataatag cttttgagct ttttatatgc     4020

atttggcacc aagactggga tccacaactt tgtagacact gcgatgaagt taacatatta     4080

gctatactat aaatagtgtt tgtaactaca cacacacaca cacacacaca cacaaataca     4140

tacatatatt ctgtaaaaac aaaaaaaaac tttttaagat ccttgggtat gtgtttgctt     4200

tactccattt cagaagaaaa ttacttttct tctaacaaaa ttattttata gcttctccat     4260

ttttaaaact tgtgagagca ttgagaagag aactctgact gtgttaacag aagagagttg     4320

aattggagtc tctgttgtgt taaaatgacc tctcgttact ccacagtagt tatttgagcc     4380

agtgactgag tcgcgttgag gaattctgaa cccggacctc tgacgttgtt gggaggtggc     4440

tgttacccac acccagacct cttgagtaag gacagaaacg ttatcattgg ggatataatg     4500

agatttcttt cttaacaatt gaaagtaata aagagttaat tttctcagta gtcctgtctt     4560

tccaaaatgc gccacagggg ctcaagatct acagaagaat cttgttatga cagtttgtta     4620

ttacccatat tcagatatcc ttgagataat ggaagagccc tgctacataa ctccctacag     4680

agaaagactg atagacttga gtagtcctta aaacaagtgt tattcctgtt caccaacccc     4740

gggactgtgg aggggtttca ctgtctatac catgcgacat ccatttcccc tgaatctcaa     4800

acgaactaga aagtatgtca tgataatatt tccattagat ttggaagcta cctgtacatc     4860

tgcaatattg tgtttttaac gccagcaccc agaactttga catgttcagt cactccctga     4920

aaggcacttc tctcttgtcc aaacacagcg ttgacatttt tactgaggag atcatctcaa     4980

aggtgatgcc aaacgagtct ggggctggtt ttaaggggac aggcacattg cagttgtagg     5040

tgttcatttt cagcatctag tagataatcc attggtgttt gtcccaccat tggtgtattc     5100

taacaagaat gtgtccaact ttgaatctcc tggcttgaaa gtataaacca tcacttaatt     5160

cttattttaa ctctccacct gaaaaccagt tcatatttct ggccatttta tgtaagcaaa     5220

actgaacaat tggtgaaaca ttttgttact cttggaattg actctggctg tcagtgtgag     5280

ccattagagt aacatcgaat cttggggcaa agaactgccc aggtgaatta aatttttcca     5340

ggacactagc tagtgtgcct tggattgatt acctcttcta ctgcattgaa aggcgccatg     5400

ttttcctgaa atactaaatt cccaacacct gggtaaacaa tgaccttcca gagagtggct     5460

cccgtatgcc tctccctagg accaacccca tgaacatgtt ttgtcacgtt tgtctcatgt     5520

ttctacttca caagtcagtg agtgtgttta aggtaagtac aggattattc tagtaggaat     5580

aggcgattgc tgtcataatc aattctcatg ttgatttcat tttattgtaa agataaattt     5640

aaacccagtt ttgcttaagc acattgatgt aattttttgg tattatttga catgaaaaaa     5700

cagcaaaatt gagtgataga tac                                             5723


<210>  8
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210>  9
<211>  3174
<212>  DNA
<213>  Homo sapiens

<400>  9
taataatggc cgtaagctta aaatagatcc agggaggagc tcattaacgt gaacatagaa       60

agcagttccg cacctctggc cttactcctc ttggaaattg ctttggtcca tttttacttc      120

cttttattcg acgcaccaga aaataagact tttaccaaca tttttactgc atttgacgat      180

gaactaattt agaccggcta aaataattgt tccactggga cacaggaatt caacctcagt      240

tcagaaaatc cctgacatct gacgtaggag gatttatagg tttagtggaa attgctttct      300

cctgctctcc agattgcatc ctgtgggttg attttttttt tgcatgagta aacatccttc      360

taataatgaa cagaccaata atgtcttaag agagaaaaag aacaatcttt tcctttttgc      420

tgtttctgga gagagctgtt tgaatttgga aacccatgtt ggctgtccca aatatgagat      480

ttggcatctt tcttttgtgg tggggatggg ttttggccac tgaaagcaga atgcactggc      540

ccggaagaga agtccacgag atgtctaaga aaggcaggcc ccaaagacaa agacgagaag      600

tacatgaaga tgcccacaag caagtcagcc caattctgag acgaagtcct gacatcacca      660

aatcgcctct gacaaagtca gaacagcttc tgaggataga tgaccatgat ttcagcatga      720

ggcctggctt tggaggccct gccattcctg ttggtgtgga tgtgcaggtg gagagtttgg      780

atagcatctc agaggttgac atggacttta cgatgaccct ctacctgagg cactactgga      840

aggacgagag gctgtctttt ccaagcacca acaacctcag catgacgttt gacggccggc      900

tggtcaagaa gatctgggtc cctgacatgt ttttcgtgca ctccaaacgc tccttcatcc      960

acgacaccac cacagacaac gtcatgttgc gggtccagcc tgatgggaaa gtgctctata     1020

gtctcagggt tacagtaact gcaatgtgca acatggactt cagccgattt cccttggaca     1080

cacaaacgtg ctctcttgaa attgaaagct atgcctatac agaagatgac ctcatgctgt     1140

actggaaaaa gggcaatgac tccttaaaga cagatgaacg gatctcactc tcccagttcc     1200

tcattcagga attccacacc accaccaaac tggctttcta cagcagcaca ggctggtaca     1260

accgtctcta cattaatttc acgttgcgtc gccacatctt cttcttcttg ctccaaactt     1320

atttccccgc taccctgatg gtcatgctgt cctgggtgtc cttctggatc gaccgcagag     1380

ccgtgcctgc cagagtcccc ttaggtatca caacggtgct gaccatgtcc accatcatca     1440

cgggcgtgaa tgcctccatg ccgcgcgtct cctacatcaa ggccgtggac atctacctct     1500

gggtcagctt tgtgttcgtg ttcctctcgg tgctggagta tgcggccgtc aactacctga     1560

ccactgtgca ggagaggaag gaacagaagc tgcgggagaa gcttccctgc accagcggat     1620

tacctccgcc ccgcactgcg atgctggacg gcaactacag tgatggggag gtgaatgacc     1680

tggacaacta catgccagag aatggagaga agcccgacag gatgatggtg cagctgaccc     1740

tggcctcaga gaggagctcc ccacagagga aaagtcagag aagcagctat gtgagcatga     1800

gaatcgacac ccacgccatt gataaatact ccaggatcat ctttccagca gcatacattt     1860

tattcaattt aatatactgg tctattttct cctagatgct tgtaattcta caaatttcac     1920

atttccatgg catgcactac agaaataact gtataatgaa aaagtattta aggatatggt     1980

taaaaaaaaa tcccaggacc cacccatgtt ttcactatcc cttctgcagc tttccaaagc     2040

tacattgacg agacacttac tggtttaatt tgcacttatt aaccatctat tgaatacaca     2100

gcattatatt aggtgctgca ggaaatacga cactgtagcg actgatgtta gttgttaccc     2160

agatcccctg gaaaagcaca ctaccagtgt tgtgggcaca tttagttcca cccgttagac     2220

ccttgatgct attcacatga ataatttatt ttcctcaagt gtcattacat tgttcaggct     2280

acgtgaactt ggaagcacct acaggccatt tgcatgaaat tcacatgcac ctaaatcctc     2340

actttgacag aaactcatgc ttcagtttat aacctattac ctattttgta tgcgactcca     2400

cctccgcatg tttattttaa taaaaggcaa tgataacatt cacattattt ttctttatat     2460

gctgtggttc acaggcttta ccccttcaca agaaaagctc tttagattgg cgcaattgct     2520

tctgattttg gtgaaatttt ccctggtagg gaaactttga agataagagt acacacatgc     2580

attttgtctg ttgtgtcata gaggtaacta ggctagaaaa tttgtgttta aatgttccct     2640

attttatata atcaccactt catgtttctt cttcttggag catgtccttg ttcaaagaga     2700

agtgctttct cagtgatgtg atatcttcac tgaggaactt gggtagagaa tgatttcttc     2760

tgcataaaca cttcaaggaa atacataatt tgggactact tgtaactcat tagaatgaga     2820

aatactcaca tggtttctta agagaaaaag aacatcggaa agcaaaataa atgggaagat     2880

atcactggac atctgcattt atactcgaaa taccagcatt ttctatggac cagaaaactg     2940

ccatcaccta gaccacacag cccagatacc aggcagacgg atggcccaat ggcaactgat     3000

gtcagggcat ggggtaaagg agagggttct aatctggtgt atcacttaaa aacagttatt     3060

tatattatat atctgctata tagatcaacc tccaccaaac ttacccaaac agcatttgtt     3120

ttatttgaaa ctcactttaa taaagtgaat tatatacaca aaaaaaaaaa aaaa           3174


<210>  10
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ala Val Pro Asn Met Arg Phe Gly Ile Phe Leu Leu Trp Trp 
1               5                   10                  15      


Gly Trp Val Leu Ala Thr Glu Ser Arg Met His Trp Pro Gly Arg Glu 
            20                  25                  30          


Val His Glu Met Ser Lys Lys Gly Arg Pro Gln Arg Gln Arg Arg Glu 
        35                  40                  45              


Val His Glu Asp Ala His Lys Gln Val Ser Pro Ile Leu Arg Arg Ser 
    50                  55                  60                  


Pro Asp Ile Thr Lys Ser Pro Leu Thr Lys Ser Glu Gln Leu Leu Arg 
65                  70                  75                  80  


Ile Asp Asp His Asp Phe Ser Met Arg Pro Gly Phe Gly Gly Pro Ala 
                85                  90                  95      


Ile Pro Val Gly Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser 
            100                 105                 110         


Glu Val Asp Met Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp 
        115                 120                 125             


Lys Asp Glu Arg Leu Ser Phe Pro Ser Thr Asn Asn Leu Ser Met Thr 
    130                 135                 140                 


Phe Asp Gly Arg Leu Val Lys Lys Ile Trp Val Pro Asp Met Phe Phe 
145                 150                 155                 160 


Val His Ser Lys Arg Ser Phe Ile His Asp Thr Thr Thr Asp Asn Val 
                165                 170                 175     


Met Leu Arg Val Gln Pro Asp Gly Lys Val Leu Tyr Ser Leu Arg Val 
            180                 185                 190         


Thr Val Thr Ala Met Cys Asn Met Asp Phe Ser Arg Phe Pro Leu Asp 
        195                 200                 205             


Thr Gln Thr Cys Ser Leu Glu Ile Glu Ser Tyr Ala Tyr Thr Glu Asp 
    210                 215                 220                 


Asp Leu Met Leu Tyr Trp Lys Lys Gly Asn Asp Ser Leu Lys Thr Asp 
225                 230                 235                 240 


Glu Arg Ile Ser Leu Ser Gln Phe Leu Ile Gln Glu Phe His Thr Thr 
                245                 250                 255     


Thr Lys Leu Ala Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr 
            260                 265                 270         


Ile Asn Phe Thr Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr 
        275                 280                 285             


Tyr Phe Pro Ala Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp 
    290                 295                 300                 


Ile Asp Arg Arg Ala Val Pro Ala Arg Val Pro Leu Gly Ile Thr Thr 
305                 310                 315                 320 


Val Leu Thr Met Ser Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro 
                325                 330                 335     


Arg Val Ser Tyr Ile Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe 
            340                 345                 350         


Val Phe Val Phe Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu 
        355                 360                 365             


Thr Thr Val Gln Glu Arg Lys Glu Gln Lys Leu Arg Glu Lys Leu Pro 
    370                 375                 380                 


Cys Thr Ser Gly Leu Pro Pro Pro Arg Thr Ala Met Leu Asp Gly Asn 
385                 390                 395                 400 


Tyr Ser Asp Gly Glu Val Asn Asp Leu Asp Asn Tyr Met Pro Glu Asn 
                405                 410                 415     


Gly Glu Lys Pro Asp Arg Met Met Val Gln Leu Thr Leu Ala Ser Glu 
            420                 425                 430         


Arg Ser Ser Pro Gln Arg Lys Ser Gln Arg Ser Ser Tyr Val Ser Met 
        435                 440                 445             


Arg Ile Asp Thr His Ala Ile Asp Lys Tyr Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Ala Ala Tyr Ile Leu Phe Asn Leu Ile Tyr Trp Ser Ile Phe Ser 
465                 470                 475                 


<210>  11
<211>  4620
<212>  DNA
<213>  Homo sapiens

<400>  11
atgccttatt ttacaagact cattttgttc ttgttttgct tgatggttct cgtggagagc       60

agaaaaccca agaggaagcg atggacaggg caggtggaaa tgcccaagcc aagtcactta      120

tataagaaga accttgatgt gaccaagatc cggaagggaa agcctcagca gcttctcaga      180

gtggacgagc acgacttcag catgagaccc gccttcggag gccctgccat cccggtgggc      240

gtggacgtac aggtggagag cctggacagc atctccgagg tggacatgga cttcactatg      300

accctgtacc tgcggcatta ctggaaggat gagaggctag ctttctccag cgccagcaac      360

aagagcatga ccttcgatgg ccggctggtg aagaagatct gggtccctga tgtcttcttt      420

gttcactcca aaagatcgtt cactcatgac accaccactg acaacatcat gctgagggtg      480

ttcccagatg gacacgtgct gtacagcatg aggattacgg tcactgccat gtgcaacatg      540

gacttcagcc actttcccct ggactcccag acctgttctt tggagctgga gagctatgcc      600

tatacagatg aagatctaat gctgtactgg aagaatgggg atgaatccct aaaaacagat      660

gagaagatct ccttgtctca gtttctgatt cagaaatttc acacaacttc caggctggcc      720

ttctacagca gcactggctg gtacaaccgt ctgtacatta acttcacgtt gcgtcgccac      780

atcttcttct tcttgctcca aacatatttc cctgccactc tgatggtcat gctgtcctgg      840

gtgtccttct ggatcgaccg cagagctgtg cctgccagag tttcactggg tatcacgacg      900

gtgctgacca tgaccaccat catcacgggc gtgaatgcct ccatgccgcg cgtctcctac      960

gtcaaggccg tggacatcta cctctgggtc agctttgtgt tcgtgttcct ctcggtgctg     1020

gagtatgcgg ctgtcaacta cctgaccacc gtgcaggagc gcaaggaacg gaagctgcgg     1080

gagaagttcc cgtgcatgtg tggaatgctt cattcaaaaa ccatgatgct ggatggaagc     1140

tacagtgagt ctgaggccaa cagcctggct gggtacccca gaagccatat cctgacagaa     1200

gaagaaaggc aagacaaaat agtggtccac ctgggcctga gtggtgaagc caacgctgcc     1260

agaaagaagg ggcttctgaa gggccagacg ggttttcgta tcttccagaa tacccatgcc     1320

attgacaaat actctaggtt gatattccct gcctcctaca tatttttcaa cttaatttat     1380

tggtcagtgt tttcctaggg gctccaaggc tgttcctaga agagggcata gacatcgagg     1440

gggcctggcc agtcattgac agacggactt gttgaccaca cgcccctcac caaacaatgc     1500

agcagctact ggaccaccct gagcagcact catctctcag agaagcccag gagccttcca     1560

gctgccctga ccccagaccc cgtggggctg ctccatgttc atgctgtctc gcgtcacact     1620

tcacatctct ctgggacctt ctgttcttgt gtgtgaacta attcacaaga actcccctcc     1680

tataaacaag gattcaaatg cctcctagac attcttagac cctcagattg cctaggagtc     1740

agttgtggag ggaaaaggaa aaactgaagt acaagcttag gggcattctg gataggagat     1800

aggaaattaa gaacaaaaaa caccctgtaa acccattgaa cttgattaag tgcctaccta     1860

gaagggaaaa gagctgagat cccagacagg aaatgatttg gcctgtggga gtatggcaac     1920

ccacaggatt ctgcaatatt agaggagatt attcatttat ccatccattc aaccattcat     1980

taaatattga ggtcccactc tgtgccaggt acggtagaaa tgagaaaata gtctctttcc     2040

ttagagatct tctctaagtt gtgctcattc tacatatggc atgatgtact tctgctcttt     2100

cccctccttc aaccccgctt accccacaga cccattctgt ttgctgttgc ttttactctt     2160

aggcatataa ggcagggtcc aggagaggcc aggtccagaa ctttcaacta tcctcctcca     2220

gtgaagttac acagatagca ctaattttgc ccagcaatga catgtagcaa tgtgcatgga     2280

gtattgccag ccagagaaac ttacccaggc tcaccacggt gtacagtttt tttattgggg     2340

tcggtcatgg atttatagct gattgcccac atggctgact ttagtctttt gcccctccag     2400

aggttaagct ggtaccttga ggtccagggc acctatcata aatcacattg ttggcataga     2460

ctatctggtg tggcccaagg ccccagtaga caaagaccct tctatctcac aggacattcc     2520

aagggcatag aggttgcttc ctagtaaagg ttagtccttt actacacagc aactcttgtc     2580

aattccctat tgttaatgtt aattgcggtg ttactattat atattcaggc aataaacatt     2640

ttaaagtatc tctgcactag gtacattggg gtccaaatta agaataagag tagtcgaagc     2700

tctcagagaa ggaactagta aaggaaatac cacacaaata tctataatat aagattaaga     2760

gtgtttagtg cctcagtaat agttcagtgt gagatgggaa ttccaaggga ggaaaaacag     2820

tcccaccagg gagacagacc tcatggagaa agcagccctg agatgcccct tgaaggtcag     2880

gattttaaga agaagaaatg gagcagaatg catcctagat ctgggctgtc tcatatggta     2940

gccactagcc acatgtctat ttaaatttaa attagtaaaa attaaaaata ttagccaggt     3000

gtggtggtgt gtgcctgggg ttctagctac tcaggaggct gaggcgggag gattgcttga     3060

gcccaggaat tccaggctgc cgtgagctgt gatcaagcca ctgcagtcca gcctgagtga     3120

cagagcgaga ccctatctct aaaataataa ttattattat ttaaattagt tgaagttaaa     3180

taaaattgaa aactcagttc cttggttaca ccatccacac tcaagtgggc ttagtaagca     3240

cagttgctag tagctactgc actgggctgg gcagcctaaa gaccaggaag ctctaccagc     3300

caagagacca gcttgagcgg acgcatgggg agaatgggaa ggtttgccat tgcagagaac     3360

agggtttgtg ggcaagtcat tcattttggc aggatcctag gctgtgataa gaggaggtga     3420

gcgactagct ttttccacaa cactagggat caaggcaggt ccccaccatg ccggtgctta     3480

tgaggacagc ttccccacta tggagttgct ggacccaaga ctactagatt tcccagtctc     3540

acagaccaat gaagaacaaa aatgcataaa tatgggtaat tgggtggtac agggcatctg     3600

gacttgttta gaaacctttt tttcttttct gagacagagt ttcactcttg ttgctcaggc     3660

tggagtgcaa tggcttgatc ttggctcacc acaacctctg cctcccgggt tcaagcaatt     3720

ctcctgcctc agccctggag tagctgggat tacaggcatg cgccaccatg cctggctaac     3780

ttttgtattt tttagtagag atggggtttc tccatgttag tcagcctggt cttgaactcc     3840

tgacctcagg tgatccgcct gcctcagcct cccaaagtgc tgtgattaca ggcgtgagcc     3900

accacacccg gccagaaacc ttttatctat agagactctc ccaggccaca gtgctgctcg     3960

aagaatgata attctattgt cattaaatat atcatattgc tttgcttgta agtcttattt     4020

aattccaacc cttctctgct tctgactgca ttgttttcat gcattatggc tcatataaca     4080

tagttgcctg ttcacaaatt aaaacaaata tttatttttg ctagcttcta tgttaaactg     4140

gagttaattc tatagcagac atatttagaa tcataaacag tgttttatca tgcagggcca     4200

tgatacaatg acaccattgt atttagcatt gccttattac agtatactag tctgacacta     4260

cttgagaaaa gtaggaaatt taaagaggta aagtggagac aacattggta ggagtagaaa     4320

acaggaacta aggaaatagt gagaacatgg gatgattcac cctggaggca ggaagacaga     4380

gaagcaaaca caattgttat caggaatgca tgaatgatac tttacttcac tgaatctaag     4440

acatggtgaa atgtaagatg cacccatatt ttatgtactg agaaaaaata ctaacaatca     4500

aattctggaa tgccaatgat tataatatga atcctgattt caccaatatg aaactgtgaa     4560

aaaatgttaa tgttacaata aaagaaatgg gttttataca aaaaaaaaaa aaaaaaaaaa     4620


<210>  12
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Tyr Phe Thr Arg Leu Ile Leu Phe Leu Phe Cys Leu Met Val 
1               5                   10                  15      


Leu Val Glu Ser Arg Lys Pro Lys Arg Lys Arg Trp Thr Gly Gln Val 
            20                  25                  30          


Glu Met Pro Lys Pro Ser His Leu Tyr Lys Lys Asn Leu Asp Val Thr 
        35                  40                  45              


Lys Ile Arg Lys Gly Lys Pro Gln Gln Leu Leu Arg Val Asp Glu His 
    50                  55                  60                  


Asp Phe Ser Met Arg Pro Ala Phe Gly Gly Pro Ala Ile Pro Val Gly 
65                  70                  75                  80  


Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser Glu Val Asp Met 
                85                  90                  95      


Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp Lys Asp Glu Arg 
            100                 105                 110         


Leu Ala Phe Ser Ser Ala Ser Asn Lys Ser Met Thr Phe Asp Gly Arg 
        115                 120                 125             


Leu Val Lys Lys Ile Trp Val Pro Asp Val Phe Phe Val His Ser Lys 
    130                 135                 140                 


Arg Ser Phe Thr His Asp Thr Thr Thr Asp Asn Ile Met Leu Arg Val 
145                 150                 155                 160 


Phe Pro Asp Gly His Val Leu Tyr Ser Met Arg Ile Thr Val Thr Ala 
                165                 170                 175     


Met Cys Asn Met Asp Phe Ser His Phe Pro Leu Asp Ser Gln Thr Cys 
            180                 185                 190         


Ser Leu Glu Leu Glu Ser Tyr Ala Tyr Thr Asp Glu Asp Leu Met Leu 
        195                 200                 205             


Tyr Trp Lys Asn Gly Asp Glu Ser Leu Lys Thr Asp Glu Lys Ile Ser 
    210                 215                 220                 


Leu Ser Gln Phe Leu Ile Gln Lys Phe His Thr Thr Ser Arg Leu Ala 
225                 230                 235                 240 


Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr Ile Asn Phe Thr 
                245                 250                 255     


Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr Tyr Phe Pro Ala 
            260                 265                 270         


Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp Ile Asp Arg Arg 
        275                 280                 285             


Ala Val Pro Ala Arg Val Ser Leu Gly Ile Thr Thr Val Leu Thr Met 
    290                 295                 300                 


Thr Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro Arg Val Ser Tyr 
305                 310                 315                 320 


Val Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe Val Phe Val Phe 
                325                 330                 335     


Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu Thr Thr Val Gln 
            340                 345                 350         


Glu Arg Lys Glu Arg Lys Leu Arg Glu Lys Phe Pro Cys Met Cys Gly 
        355                 360                 365             


Met Leu His Ser Lys Thr Met Met Leu Asp Gly Ser Tyr Ser Glu Ser 
    370                 375                 380                 


Glu Ala Asn Ser Leu Ala Gly Tyr Pro Arg Ser His Ile Leu Thr Glu 
385                 390                 395                 400 


Glu Glu Arg Gln Asp Lys Ile Val Val His Leu Gly Leu Ser Gly Glu 
                405                 410                 415     


Ala Asn Ala Ala Arg Lys Lys Gly Leu Leu Lys Gly Gln Thr Gly Phe 
            420                 425                 430         


Arg Ile Phe Gln Asn Thr His Ala Ile Asp Lys Tyr Ser Arg Leu Ile 
        435                 440                 445             


Phe Pro Ala Ser Tyr Ile Phe Phe Asn Leu Ile Tyr Trp Ser Val Phe 
    450                 455                 460                 


Ser 
465 


<210>  13
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  13
atggtcctgg ctttccagtt agtctccttc acctacatct ggatcatatt gaaaccaaat       60

gtttgtgctg cttctaacat caagatgaca caccagcggt gctcctcttc aatgaaacaa      120

acctgcaaac aagaaactag aatgaagaaa gatgacagta ccaaagcgcg gcctcagaaa      180

tatgagcaac ttctccatat agaggacaac gatttcgcaa tgagacctgg atttggaggg      240

tctccagtgc cagtaggtat agatgtccat gttgaaagca ttgacagcat ttcagagact      300

aacatggact ttacaatgac tttttatctc aggcattact ggaaagacga gaggctctcc      360

tttcctagca cagcaaacaa aagcatgaca tttgatcata gattgaccag aaagatctgg      420

gtgcctgata tcttttttgt ccactctaaa agatccttca tccatgatac aactatggag      480

aatatcatgc tgcgcgtaca ccctgatgga aacgtcctcc taagtctcag gataacggtt      540

tcggccatgt gctttatgga tttcagcagg tttcctcttg acactcaaaa ttgttctctt      600

gaactggaaa gctatgccta caatgaggat gacctaatgc tatactggaa acacggaaac      660

aagtccttaa atactgaaga acatatgtcc ctttctcagt tcttcattga agacttcagt      720

gcatctagtg gattagcttt ctatagcagc acaggttggt acaataggct tttcatcaac      780

tttgtgctaa ggaggcatgt tttcttcttt gtgctgcaaa cctatttccc agccatattg      840

atggtgatgc tttcatgggt ttcattttgg attgaccgaa gagctgttcc tgcaagagtt      900

tccctgggaa tcaccacagt gctgaccatg tccacaatca tcactgctgt gagcgcctcc      960

atgccccagg tgtcctacct caaggctgtg gatgtgtacc tgtgggtcag ctccctcttt     1020

gtgttcctgt cagtcattga gtatgcagct gtgaactacc tcaccacagt ggaagagcgg     1080

aaacaattca agaagacagg aaagatttct aggatgtaca atattgatgc agttcaagct     1140

atggcctttg atggttgtta ccatgacagc gagattgaca tggaccagac ttccctctct     1200

ctaaactcag aagacttcat gagaagaaaa tcgatatgca gccccagcac cgattcatct     1260

cggataaaga gaagaaaatc cctaggagga catgttggta gaatcattct ggaaaacaac     1320

catgtcattg acacctattc taggatttta ttccccattg tgtatatttt atttaatttg     1380

ttttactggg gtgtatatgt atga                                            1404


<210>  14
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Leu Ala Phe Gln Leu Val Ser Phe Thr Tyr Ile Trp Ile Ile 
1               5                   10                  15      


Leu Lys Pro Asn Val Cys Ala Ala Ser Asn Ile Lys Met Thr His Gln 
            20                  25                  30          


Arg Cys Ser Ser Ser Met Lys Gln Thr Cys Lys Gln Glu Thr Arg Met 
        35                  40                  45              


Lys Lys Asp Asp Ser Thr Lys Ala Arg Pro Gln Lys Tyr Glu Gln Leu 
    50                  55                  60                  


Leu His Ile Glu Asp Asn Asp Phe Ala Met Arg Pro Gly Phe Gly Gly 
65                  70                  75                  80  


Ser Pro Val Pro Val Gly Ile Asp Val His Val Glu Ser Ile Asp Ser 
                85                  90                  95      


Ile Ser Glu Thr Asn Met Asp Phe Thr Met Thr Phe Tyr Leu Arg His 
            100                 105                 110         


Tyr Trp Lys Asp Glu Arg Leu Ser Phe Pro Ser Thr Ala Asn Lys Ser 
        115                 120                 125             


Met Thr Phe Asp His Arg Leu Thr Arg Lys Ile Trp Val Pro Asp Ile 
    130                 135                 140                 


Phe Phe Val His Ser Lys Arg Ser Phe Ile His Asp Thr Thr Met Glu 
145                 150                 155                 160 


Asn Ile Met Leu Arg Val His Pro Asp Gly Asn Val Leu Leu Ser Leu 
                165                 170                 175     


Arg Ile Thr Val Ser Ala Met Cys Phe Met Asp Phe Ser Arg Phe Pro 
            180                 185                 190         


Leu Asp Thr Gln Asn Cys Ser Leu Glu Leu Glu Ser Tyr Ala Tyr Asn 
        195                 200                 205             


Glu Asp Asp Leu Met Leu Tyr Trp Lys His Gly Asn Lys Ser Leu Asn 
    210                 215                 220                 


Thr Glu Glu His Met Ser Leu Ser Gln Phe Phe Ile Glu Asp Phe Ser 
225                 230                 235                 240 


Ala Ser Ser Gly Leu Ala Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg 
                245                 250                 255     


Leu Phe Ile Asn Phe Val Leu Arg Arg His Val Phe Phe Phe Val Leu 
            260                 265                 270         


Gln Thr Tyr Phe Pro Ala Ile Leu Met Val Met Leu Ser Trp Val Ser 
        275                 280                 285             


Phe Trp Ile Asp Arg Arg Ala Val Pro Ala Arg Val Ser Leu Gly Ile 
    290                 295                 300                 


Thr Thr Val Leu Thr Met Ser Thr Ile Ile Thr Ala Val Ser Ala Ser 
305                 310                 315                 320 


Met Pro Gln Val Ser Tyr Leu Lys Ala Val Asp Val Tyr Leu Trp Val 
                325                 330                 335     


Ser Ser Leu Phe Val Phe Leu Ser Val Ile Glu Tyr Ala Ala Val Asn 
            340                 345                 350         


Tyr Leu Thr Thr Val Glu Glu Arg Lys Gln Phe Lys Lys Thr Gly Lys 
        355                 360                 365             


Ile Ser Arg Met Tyr Asn Ile Asp Ala Val Gln Ala Met Ala Phe Asp 
    370                 375                 380                 


Gly Cys Tyr His Asp Ser Glu Ile Asp Met Asp Gln Thr Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Glu Asp Phe Met Arg Arg Lys Ser Ile Cys Ser Pro Ser 
                405                 410                 415     


Thr Asp Ser Ser Arg Ile Lys Arg Arg Lys Ser Leu Gly Gly His Val 
            420                 425                 430         


Gly Arg Ile Ile Leu Glu Asn Asn His Val Ile Asp Thr Tyr Ser Arg 
        435                 440                 445             


Ile Leu Phe Pro Ile Val Tyr Ile Leu Phe Asn Leu Phe Tyr Trp Gly 
    450                 455                 460                 


Val Tyr Val 
465         


<210>  15
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  15
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccagtga     1320


<210>  16
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  16

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  17
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  17

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  18
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  18

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


His Leu Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  19
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  19

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Thr Leu Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  20
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  20
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta tcctatgtga aagccattga catttggatg      900

gcagtttgcc tgctctttgt gttctcagcc ctattagaat atgctgccgt taactttgtg      960

tctcggcaac ataaggagct gctccgattc aggaggaagc ggagacatca caagagcccc     1020

atgttgaatc tattccagga ggatgaagct ggagaaggcc gctttaactt ctctgcctat     1080

gggatgggcc cagcctgtct acaggccaag gatggcatct cagtcaaggg cgccaacaac     1140

agtaacacca ccaacccccc tcctgcacca tctaagtccc cagaggagat gcgaaaactc     1200

ttcatccaga gggccaagaa gatcgacaaa atatcccgca ttggcttccc catggccttc     1260

ctcattttca acatgttcta ctggatcatc tacaagattg tccgtagaga ggacgtccac     1320

aaccagtga                                                             1329


<210>  21
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  21

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu 
    290                 295                 300                 


Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val 
305                 310                 315                 320 


Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His 
                325                 330                 335     


His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu 
            340                 345                 350         


Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln 
        355                 360                 365             


Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr 
    370                 375                 380                 


Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu 
385                 390                 395                 400 


Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe 
                405                 410                 415     


Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys 
            420                 425                 430         


Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440         


<210>  22
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  22
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta ccattgatag cccaggccat tgacatttgg      900

atggcagttt gcctgctctt tgtgttctca gccctattag aatatgctgc cgttaacttt      960

gtgtctcggc aacataagga gctgctccga ttcaggagga agcggagaca tcacaagagc     1020

cccatgttga atctattcca ggaggatgaa gctggagaag gccgctttaa cttctctgcc     1080

tatgggatgg gcccagcctg tctacaggcc aaggatggca tctcagtcaa gggcgccaac     1140

aacagtaaca ccaccaaccc ccctcctgca ccatctaagt ccccagagga gatgcgaaaa     1200

ctcttcatcc agagggccaa gaagatcgac aaaatatccc gcattggctt ccccatggcc     1260

ttcctcattt tcaacatgtt ctactggatc atctacaaga ttgtccgtag agaggacgtc     1320

cacaaccagt ga                                                         1332


<210>  23
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  23

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Ala Ile Asp Ile Trp Met Ala Val Cys 
    290                 295                 300                 


Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe 
305                 310                 315                 320 


Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg 
                325                 330                 335     


His His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly 
            340                 345                 350         


Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu 
        355                 360                 365             


Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr 
    370                 375                 380                 


Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys 
385                 390                 395                 400 


Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly 
                405                 410                 415     


Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr 
            420                 425                 430         


Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440             


<210>  24
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  24
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtccgattcg gtaccattga ttgacatttg gatggcagtt      900

tgcctgctct ttgtgttctc agccctatta gaatatgctg ccgttaactt tgtgtctcgg      960

caacataagg agctgctccg attcaggagg aagcggagac atcacaagag ccccatgttg     1020

aatctattcc aggaggatga agctggagaa ggccgcttta acttctctgc ctatgggatg     1080

ggcccagcct gtctacaggc caaggatggc atctcagtca agggcgccaa caacagtaac     1140

accaccaacc cccctcctgc accatctaag tccccagagg agatgcgaaa actcttcatc     1200

cagagggcca agaagatcga caaaatatcc cgcattggct tccccatggc cttcctcatt     1260

ttcaacatgt tctactggat catctacaag attgtccgta gagaggacgt ccacaaccag     1320

tga                                                                   1323


<210>  25
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  25

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Asp Ser Val Pro Leu Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe 
    290                 295                 300                 


Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg 
305                 310                 315                 320 


Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys 
                325                 330                 335     


Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg 
            340                 345                 350         


Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys 
        355                 360                 365             


Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro 
    370                 375                 380                 


Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile 
385                 390                 395                 400 


Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met 
                405                 410                 415     


Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val 
            420                 425                 430         


Arg Arg Glu Asp Val His Asn Gln 
        435                 440 


<210>  26
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  26
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgga gcggcagatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta ccattgatag cccaggccat tgacatttgg      900

atggcagttt gcctgctctt tgtgttctca gccctattag aatatgctgc cgttaacttt      960

gtgtctcggc aacataagga gctgctccga ttcaggagga agcggagaca tcacaagagc     1020

cccatgttga atctattcca ggaggatgaa gctggagaag gccgctttaa cttctctgcc     1080

tatgggatgg gcccagcctg tctacaggcc aaggatggca tctcagtcaa gggcgccaac     1140

aacagtaaca ccaccaaccc ccctcctgca ccatctaagt ccccagagga gatgcgaaaa     1200

ctcttcatcc agagggccaa gaagatcgac aaaatatccc gcattggctt ccccatggcc     1260

ttcctcattt tcaacatgtt ctactggatc atctacaaga ttgtccgtag agaggacgtc     1320

cacaaccagt ga                                                         1332


<210>  27
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  27

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Ala Ile Asp Ile Trp Met Ala Val Cys 
    290                 295                 300                 


Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe 
305                 310                 315                 320 


Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg 
                325                 330                 335     


His His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly 
            340                 345                 350         


Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu 
        355                 360                 365             


Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr 
    370                 375                 380                 


Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys 
385                 390                 395                 400 


Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly 
                405                 410                 415     


Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr 
            420                 425                 430         


Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440             


<210>  28
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  28
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggacg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta ccattgatag cccaggccat tgacatttgg      900

atggcagttt gcctgctctt tgtgttctca gccctattag aatatgctgc cgttaacttt      960

gtgtctcggc aacataagga gctgctccga ttcaggagga agcggagaca tcacaagagc     1020

cccatgttga atctattcca ggaggatgaa gctggagaag gccgctttaa cttctctgcc     1080

tatgggatgg gcccagcctg tctacaggcc aaggatggca tctcagtcaa gggcgccaac     1140

aacagtaaca ccaccaaccc ccctcctgca ccatctaagt ccccagagga gatgcgaaaa     1200

ctcttcatcc agagggccaa gaagatcgac aaaatatccc gcattggctt ccccatggcc     1260

ttcctcattt tcaacatgtt ctactggatc atctacaaga ttgtccgtag agaggacgtc     1320

cacaaccagt ga                                                         1332


<210>  29
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  29

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Thr Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Ala Ile Asp Ile Trp Met Ala Val Cys 
    290                 295                 300                 


Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe 
305                 310                 315                 320 


Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg 
                325                 330                 335     


His His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly 
            340                 345                 350         


Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu 
        355                 360                 365             


Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr 
    370                 375                 380                 


Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys 
385                 390                 395                 400 


Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly 
                405                 410                 415     


Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr 
            420                 425                 430         


Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440             


<210>  30
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  30
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggacg ctctactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta ccattgatag cccaggccat tgacatttgg      900

atggcagttt gcctgctctt tgtgttctca gccctattag aatatgctgc cgttaacttt      960

gtgtctcggc aacataagga gctgctccga ttcaggagga agcggagaca tcacaagagc     1020

cccatgttga atctattcca ggaggatgaa gctggagaag gccgctttaa cttctctgcc     1080

tatgggatgg gcccagcctg tctacaggcc aaggatggca tctcagtcaa gggcgccaac     1140

aacagtaaca ccaccaaccc ccctcctgca ccatctaagt ccccagagga gatgcgaaaa     1200

ctcttcatcc agagggccaa gaagatcgac aaaatatccc gcattggctt ccccatggcc     1260

ttcctcattt tcaacatgtt ctactggatc atctacaaga ttgtccgtag agaggacgtc     1320

cacaaccagt ga                                                         1332


<210>  31
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  31

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Thr Leu Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Ala Ile Asp Ile Trp Met Ala Val Cys 
    290                 295                 300                 


Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe 
305                 310                 315                 320 


Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg 
                325                 330                 335     


His His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly 
            340                 345                 350         


Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu 
        355                 360                 365             


Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr 
    370                 375                 380                 


Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys 
385                 390                 395                 400 


Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly 
                405                 410                 415     


Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr 
            420                 425                 430         


Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440             


<210>  32
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  32
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt ccccatggat      480

gtccagacat gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccagtga     1320


<210>  33
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  33

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  34
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  34
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccagtga     1320


<210>  35
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  35

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  36
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  36
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gacaaccatg gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccagtga     1320


<210>  37
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  37

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Thr Thr Met Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  38
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  38
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acattgctga gacaaccatg gacttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt ccccatggat      480

gtccagacat gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccagtga     1320


<210>  39
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  39

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Ile Ala Glu Thr Thr Met Asp Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  40
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  40
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gacaaccatg gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt ccccatggat      480

gtccagacat gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccagtga     1320


<210>  41
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  41

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Thr Thr Met Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  42
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  42
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gacaaccatg gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt ccccatggat      480

gtccagacat gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgga gcggcagatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccag        1317


<210>  43
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  43

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Thr Thr Met Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  44
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  44
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acattgctga gacaaccatg gacttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt ccccatggat      480

gtccagacat gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgga gcggcagatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

cgagcatctc tgcccaaggt gtcctatgtg aaagccattg acatttggat ggcagtttgc      900

ctgctctttg tgttctcagc cctattagaa tatgctgccg ttaactttgt gtctcggcaa      960

cataaggagc tgctccgatt caggaggaag cggagacatc acaagagccc catgttgaat     1020

ctattccagg aggatgaagc tggagaaggc cgctttaact tctctgccta tgggatgggc     1080

ccagcctgtc tacaggccaa ggatggcatc tcagtcaagg gcgccaacaa cagtaacacc     1140

accaaccccc ctcctgcacc atctaagtcc ccagaggaga tgcgaaaact cttcatccag     1200

agggccaaga agatcgacaa aatatcccgc attggcttcc ccatggcctt cctcattttc     1260

aacatgttct actggatcat ctacaagatt gtccgtagag aggacgtcca caaccag        1317


<210>  45
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  45

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Ile Ala Glu Thr Thr Met Asp Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Glu Arg Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  46
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  46
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gacaaccatg gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc tacatcgatg tacgctggtt tccctttgat      480

gtgcagcact gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta ccattgatag cccaggccat tgacatttgg      900

atggcagttt gcctgctctt tgtgttctca gccctattag aatatgctgc cgttaacttt      960

gtgtctcggc aacataagga gctgctccga ttcaggagga agcggagaca tcacaagagc     1020

cccatgttga atctattcca ggaggatgaa gctggagaag gccgctttaa cttctctgcc     1080

tatgggatgg gcccagcctg tctacaggcc aaggatggca tctcagtcaa gggcgccaac     1140

aacagtaaca ccaccaaccc ccctcctgca ccatctaagt ccccagagga gatgcgaaaa     1200

ctcttcatcc agagggccaa gaagatcgac aaaatatccc gcattggctt ccccatggcc     1260

ttcctcattt tcaacatgtt ctactggatc atctacaaga ttgtccgtag agaggacgtc     1320

cacaaccag                                                             1329


<210>  47
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  47

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Thr Thr Met Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Tyr Ile Asp Val Arg Trp Phe Pro Phe Asp 
145                 150                 155                 160 


Val Gln His Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Ala Ile Asp Ile Trp Met Ala Val Cys 
    290                 295                 300                 


Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe 
305                 310                 315                 320 


Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg 
                325                 330                 335     


His His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly 
            340                 345                 350         


Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu 
        355                 360                 365             


Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr 
    370                 375                 380                 


Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys 
385                 390                 395                 400 


Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly 
                405                 410                 415     


Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr 
            420                 425                 430         


Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440             


<210>  48
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  48
atgcgctgct cgccgggagg cgtctggctg gcgctggccg cgtcgctcct gcacgtgtcc       60

ctgcaaggcg agttccagag gaagctttac aaggagctgg tcaagaacta caatcccttg      120

gagaggcccg tggccaatga ctcgcaacca ctcaccgtct acttctccct gagcctcctg      180

cagatcatgg acgtggatga gaagaaccaa gttttaacca ccaacatttg gctgcaaatg      240

tcttggacag atcactattt acagtggaat gtgtcagaat atccaggggt gaagactgtt      300

cgtttcccag atggccagat ttggaaacca gacattcttc tctataacag tgctgatgag      360

cgctttgacg ccacattcca cactaacgtg ttggtgaact cttctgggca ttgccagtac      420

ctgcctccag gcatattcaa gagttcctgc cccatggact tgaagaattt ccccatggat      480

gtccagacat gcaaactgaa gtttgggtcc tggtcttacg gaggctggtc cttggatctg      540

cagatgcagg aggcagatat cagtggctat atccccaatg gagaatggga cctagtggga      600

atccccggca agaggagtga aaggttctat gagtgctgca aagagcccta ccccgatgtc      660

accttcacag tgaccatgcg ccgcaggatg ggttactacc tgattcagat gtatattccc      720

agcctgctca ttgtcatcct ctcatggatc tccttctgga tcaacatgga tgctgcacct      780

gctcgtgtgg gcctaggcat caccactgtg ctcaccatga ccacccagag ctccggctct      840

gagatcatgc ccgcaacatc cgattcggta ccattgatag cccaggccat tgacatttgg      900

atggcagttt gcctgctctt tgtgttctca gccctattag aatatgctgc cgttaacttt      960

gtgtctcggc aacataagga gctgctccga ttcaggagga agcggagaca tcacaagagc     1020

cccatgttga atctattcca ggaggatgaa gctggagaag gccgctttaa cttctctgcc     1080

tatgggatgg gcccagcctg tctacaggcc aaggatggca tctcagtcaa gggcgccaac     1140

aacagtaaca ccaccaaccc ccctcctgca ccatctaagt ccccagagga gatgcgaaaa     1200

ctcttcatcc agagggccaa gaagatcgac aaaatatccc gcattggctt ccccatggcc     1260

ttcctcattt tcaacatgtt ctactggatc atctacaaga ttgtccgtag agaggacgtc     1320

cacaaccagt ga                                                         1332


<210>  49
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  49

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Glu Ile Met Pro Ala Thr Ser Asp 
        275                 280                 285             


Ser Val Pro Leu Ile Ala Gln Ala Ile Asp Ile Trp Met Ala Val Cys 
    290                 295                 300                 


Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe 
305                 310                 315                 320 


Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg 
                325                 330                 335     


His His Lys Ser Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly 
            340                 345                 350         


Glu Gly Arg Phe Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu 
        355                 360                 365             


Gln Ala Lys Asp Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr 
    370                 375                 380                 


Thr Asn Pro Pro Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys 
385                 390                 395                 400 


Leu Phe Ile Gln Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly 
                405                 410                 415     


Phe Pro Met Ala Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr 
            420                 425                 430         


Lys Ile Val Arg Arg Glu Asp Val His Asn Gln 
        435                 440             


<210>  50
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  50

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
            20                  25                  30          


Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
        35                  40                  45              


Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
    50                  55                  60                  


Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
65                  70                  75                  80  


Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                85                  90                  95      


Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
            100                 105                 110         


Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
        115                 120                 125             


Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
    130                 135                 140                 


Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
145                 150                 155                 160 


Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                165                 170                 175     


Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
            180                 185                 190         


Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
        195                 200                 205             


Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
    210                 215                 220                 


Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val Val Ile Arg Arg 
225                 230                 235                 240 


Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile 
                245                 250                 255     


Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro 
            260                 265                 270         


Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln 
        275                 280                 285             


Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala 
    290                 295                 300                 


Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Leu 
                325                 330                 335     


Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser Pro Met Leu Asn 
            340                 345                 350         


Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe Asn Phe Ser Ala 
        355                 360                 365             


Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp Gly Ile Ser Val 
    370                 375                 380                 


Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro Pro Ala Pro Ser 
385                 390                 395                 400 


Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln Arg Ala Lys Lys 
                405                 410                 415     


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
            420                 425                 430         


Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val 
        435                 440                 445             


His Asn Gln 
    450     


<210>  51
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  51

Met Leu Leu Trp Val Gln Gln Ala Leu Leu Ala Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Leu Ala Gln Gly Glu Ala Arg Arg Ser Arg Asn Thr Thr Arg Pro 
            20                  25                  30          


Ala Leu Leu Arg Leu Ser Asp Tyr Leu Leu Thr Asn Tyr Arg Lys Gly 
        35                  40                  45              


Val Arg Pro Val Arg Asp Trp Arg Lys Pro Thr Thr Val Ser Ile Asp 
    50                  55                  60                  


Val Ile Val Tyr Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val Leu 
65                  70                  75                  80  


Thr Thr Tyr Ile Trp Tyr Arg Gln Tyr Trp Thr Asp Glu Phe Leu Gln 
                85                  90                  95      


Trp Asn Pro Glu Asp Phe Asp Asn Ile Thr Lys Leu Ser Ile Pro Thr 
            100                 105                 110         


Asp Ser Ile Trp Val Pro Asp Ile Leu Ile Asn Glu Phe Val Asp Val 
        115                 120                 125             


Gly Lys Ser Pro Asn Ile Pro Tyr Val Tyr Ile Arg His Gln Gly Glu 
    130                 135                 140                 


Val Gln Asn Tyr Lys Pro Leu Gln Val Val Thr Ala Cys Ser Leu Asp 
145                 150                 155                 160 


Ile Tyr Asn Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Thr 
                165                 170                 175     


Ser Trp Leu His Thr Ile Gln Asp Ile Asn Ile Ser Leu Trp Arg Leu 
            180                 185                 190         


Pro Glu Lys Val Lys Ser Asp Arg Ser Val Phe Met Asn Gln Gly Glu 
        195                 200                 205             


Trp Glu Leu Leu Gly Val Leu Pro Tyr Phe Arg Glu Phe Ser Met Glu 
    210                 215                 220                 


Ser Ser Asn Tyr Tyr Ala Glu Met Lys Phe Tyr Val His Leu Glu Arg 
225                 230                 235                 240 


Gln Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile 
                245                 250                 255     


Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met Asp Ala Ala Pro 
            260                 265                 270         


Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln 
        275                 280                 285             


Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala 
    290                 295                 300                 


Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu 
305                 310                 315                 320 


Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Leu 
                325                 330                 335     


Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser Pro Met Leu Asn 
            340                 345                 350         


Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe Asn Phe Ser Ala 
        355                 360                 365             


Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp Gly Ile Ser Val 
    370                 375                 380                 


Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro Pro Ala Pro Ser 
385                 390                 395                 400 


Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln Arg Ala Lys Lys 
                405                 410                 415     


Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala Phe Leu Ile Phe 
            420                 425                 430         


Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg Arg Glu Asp Val 
        435                 440                 445             


His Asn Gln 
    450     


<210>  52
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  52

Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
                245                 250                 255     


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
            260                 265                 270         


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
        275                 280                 285             


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
    290                 295                 300                 


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
305                 310                 315                 320 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
                325                 330                 335     


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
            340                 345                 350         


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
        355                 360                 365             


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
    370                 375                 380                 


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
385                 390                 395                 400 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
                405                 410                 415     


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
            420                 425                 430         


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
        435                 440                 445             


Arg Glu Asp Val His Asn Gln 
    450                 455 


<210>  53
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal amino acids of GABAR1

<400>  53

Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly Ile Phe 
1               5                   10                  15      


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln Leu 
            20                  25                  30      


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid residues 260-281 of human CHRNA7

<400>  54

Glu Lys Ile Ser Leu Gly Ile Thr Val Leu Leu Ser Leu Thr Val Phe 
1               5                   10                  15      


Met Leu Leu Val Ala Glu 
            20          


<210>  55
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence

<400>  55

Pro Ala Lys Ile Gly Leu Gly Ile Thr Val Leu Leu Ser Leu Thr Thr 
1               5                   10                  15      


Phe Met Ser Gly Val Ala Asn 
            20              


<210>  56
<211>  1780
<212>  DNA
<213>  Homo sapiens

<400>  56
atgttgtcaa gtgtaatggc tcccctgtgg gcctgcatcc tggtggctgc aggaattcta       60

gccacagata cacatcatcc ccaggattct gctctgtatc atctcagcaa gcagctatta      120

cagaaatatc ataaagaagt gagacctgtt tacaactgga ccaaggccac cacagtctac      180

ctggacctgt tcgtccatgc tatattggat gtggatgcag agaatcaaat attaaagaca      240

agtgtatggt accaagaggt ctggaatgat gaatttttat cctggaactc cagcatgttt      300

gatgagatta gagagatctc cctacctcta agtgccatct gggcccccga tatcatcatc      360

aatgagtttg tggacattga aagataccct gaccttccct atgtttatgt gaactcatct      420

gggaccattg agaactataa gcccatccag gtggtctctg cgtgcagttt agagacatat      480

gcttttccat ttgatgtcca gaattgcagc ctgaccttca agagcattct gcatacagtg      540

gaagacgtag acctggcctt tctgaggagc ccagaagaca ttcagcatga caaaaaggcg      600

tttttgaatg acagtgagtg ggaacttcta tctgtgtcct ccacatacag catcctgcag      660

agcagcgctg gaggatttgc acagattcag tttaatgtgg tgatgcgcag gcaccccctg      720

gtctatgtcg tgagtctgct gattcctagc atctttctca tgctggtgga cctggggagc      780

ttctacctgc cacccaactg ccgagccagg attgtgttca agaccagtgt gctggtgggc      840

tacaccgtct tcagggtcaa catgtccaac caggtgccac ggagtgtagg gagcacccct      900

ctgattgggc acttcttcac catctgcatg gccttcttgg ttctcagctt agctaagtcc      960

atcgtgttgg tcaaattcct ccatgatgag cagcgtggtg gacaggagca gcccttcttg     1020

tgccttcgag gggacaccga tgctgacagg cctagagtgg aacccagggc ccaacgtgct     1080

gtggtaacag agtcctcgct gtatggagag cacctggccc agccaggaac cctgaaggaa     1140

gtctggtcgc agcttcaatc tatcagcaac tacctccaaa ctcaggacca gacagaccaa     1200

caggaggcag agtggctggt cctcctgtcc cgctttgacc gactgctctt ccaaagctac     1260

cttttcatgc tggggatcta caccatcact ctgtgctccc tctgggcact gtggggcggc     1320

gtgtgaagac tgaagtgttc ttcagtaatt gtgctggcac ttaggagaga gaggaggggg     1380

aataatagtg ggttaaaaag ctttctgggt cgggtgtggt ggttcttgcc tatagtccca     1440

gtgctttggg aggccatagc aggaggattg cttgagccca ggagttcgag accagccaga     1500

gcaacatagt gagaccacat ctctaccagt aaataaataa ataaataaat aaataaataa     1560

ataaataaat agctgggcat agtggctcat gcctgtactc tcagctactt gggaggttga     1620

ggtgggagga ttgcttgagc ccaggatttc aaggctgcag tgagccatga ttgcaccact     1680

gcaccccagc ctgggtgaca gagcaagacc ctgtctcaaa aaaaataaaa taaaaggctt     1740

tctgccttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1780


<210>  57
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Leu Ser Ser Val Met Ala Pro Leu Trp Ala Cys Ile Leu Val Ala 
1               5                   10                  15      


Ala Gly Ile Leu Ala Thr Asp Thr His His Pro Gln Asp Ser Ala Leu 
            20                  25                  30          


Tyr His Leu Ser Lys Gln Leu Leu Gln Lys Tyr His Lys Glu Val Arg 
        35                  40                  45              


Pro Val Tyr Asn Trp Thr Lys Ala Thr Thr Val Tyr Leu Asp Leu Phe 
    50                  55                  60                  


Val His Ala Ile Leu Asp Val Asp Ala Glu Asn Gln Ile Leu Lys Thr 
65                  70                  75                  80  


Ser Val Trp Tyr Gln Glu Val Trp Asn Asp Glu Phe Leu Ser Trp Asn 
                85                  90                  95      


Ser Ser Met Phe Asp Glu Ile Arg Glu Ile Ser Leu Pro Leu Ser Ala 
            100                 105                 110         


Ile Trp Ala Pro Asp Ile Ile Ile Asn Glu Phe Val Asp Ile Glu Arg 
        115                 120                 125             


Tyr Pro Asp Leu Pro Tyr Val Tyr Val Asn Ser Ser Gly Thr Ile Glu 
    130                 135                 140                 


Asn Tyr Lys Pro Ile Gln Val Val Ser Ala Cys Ser Leu Glu Thr Tyr 
145                 150                 155                 160 


Ala Phe Pro Phe Asp Val Gln Asn Cys Ser Leu Thr Phe Lys Ser Ile 
                165                 170                 175     


Leu His Thr Val Glu Asp Val Asp Leu Ala Phe Leu Arg Ser Pro Glu 
            180                 185                 190         


Asp Ile Gln His Asp Lys Lys Ala Phe Leu Asn Asp Ser Glu Trp Glu 
        195                 200                 205             


Leu Leu Ser Val Ser Ser Thr Tyr Ser Ile Leu Gln Ser Ser Ala Gly 
    210                 215                 220                 


Gly Phe Ala Gln Ile Gln Phe Asn Val Val Met Arg Arg His Pro Leu 
225                 230                 235                 240 


Val Tyr Val Val Ser Leu Leu Ile Pro Ser Ile Phe Leu Met Leu Val 
                245                 250                 255     


Asp Leu Gly Ser Phe Tyr Leu Pro Pro Asn Cys Arg Ala Arg Ile Val 
            260                 265                 270         


Phe Lys Thr Ser Val Leu Val Gly Tyr Thr Val Phe Arg Val Asn Met 
        275                 280                 285             


Ser Asn Gln Val Pro Arg Ser Val Gly Ser Thr Pro Leu Ile Gly His 
    290                 295                 300                 


Phe Phe Thr Ile Cys Met Ala Phe Leu Val Leu Ser Leu Ala Lys Ser 
305                 310                 315                 320 


Ile Val Leu Val Lys Phe Leu His Asp Glu Gln Arg Gly Gly Gln Glu 
                325                 330                 335     


Gln Pro Phe Leu Cys Leu Arg Gly Asp Thr Asp Ala Asp Arg Pro Arg 
            340                 345                 350         


Val Glu Pro Arg Ala Gln Arg Ala Val Val Thr Glu Ser Ser Leu Tyr 
        355                 360                 365             


Gly Glu His Leu Ala Gln Pro Gly Thr Leu Lys Glu Val Trp Ser Gln 
    370                 375                 380                 


Leu Gln Ser Ile Ser Asn Tyr Leu Gln Thr Gln Asp Gln Thr Asp Gln 
385                 390                 395                 400 


Gln Glu Ala Glu Trp Leu Val Leu Leu Ser Arg Phe Asp Arg Leu Leu 
                405                 410                 415     


Phe Gln Ser Tyr Leu Phe Met Leu Gly Ile Tyr Thr Ile Thr Leu Cys 
            420                 425                 430         


Ser Leu Trp Ala Leu Trp Gly Gly Val 
        435                 440     


<210>  58
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  58

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Asp Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Asp Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  59
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  59

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Ser Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Asp Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  60
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  60

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Thr Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Asp Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  61
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  61

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Asp Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Glu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  62
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  62

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Asp Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Gln Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  63
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  63

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Asp Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Thr Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  64
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  64

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Ile Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  65
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  65

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Gly Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  66
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  66

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Asp Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  67
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  67

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Glu Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Trp Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  68
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  68

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Trp Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Val Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  69
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  69

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Val Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  70
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  70

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Phe Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  71
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  71

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Met Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Ala Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  72
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  72

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Met Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Phe Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  73
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  73

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Trp Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Glu Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Trp Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  74
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  74

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Glu Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Trp Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  75
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  75

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Phe Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Asp Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  76
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  76

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Phe Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Asn Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Asp Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  77
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  77

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Glu Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Asp Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  78
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  78

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Tyr Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Asp Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Trp Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


<210>  79
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV5 capsid protein

<400>  79

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  80
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV6 capsid protein

<400>  80

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  81
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 capsid protein

<400>  81

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  82
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  82
atgaaccggc agctagtgaa cattttgaca gccttgtttg catttttctt agagacaaac       60

cacttcagga cggctttctg caaagaccat gactccaggt ctggaaaaca accttcacag      120

accctatctc cttcagattt cttggacaag ttaatgggaa ggacatcagg atatgatgca      180

agaatcaggc caaattttaa aggtcctcca gtaaacgtta cttgcaatat ttttatcaac      240

agttttggat cagtcacaga aacgaccatg gactaccgag tgaatatttt tctgagacaa      300

cagtggaatg attcacggct ggcgtacagt gagtacccag atgactccct ggacttggac      360

ccatccatgc tagactccat ttggaaacca gatttgttct ttgccaatga gaagggtgcc      420

aacttccacg atgtcaccac tgacaacaaa ttgctacgga tttcgaaaaa tggcaaagtg      480

ctctacagta tcagactcac cttgacctta tcctgtccca tggacttgaa gaactttccg      540

atggatgtcc agacctgtac aatgcagctg gagagttttg ggtacacgat gaatgacctg      600

atatttgagt ggttaagtga tggtccagtg caagttgctg aaggattgac cctgccccag      660

tttattttga aagaagagaa ggaacttggc tactgtacaa agcactacaa cactggaaag      720

tttacctgca ttgaggtcaa gtttcatctg gaacgccaaa tgggatatta tttgatccag      780

atgtacatcc caagcctgct tatagtaatt ttgtcctggg tttccttttg gataaatatg      840

gatgcagccc ctgccagggt cgcactgggc atcaccacag tcttaacgat gaccacccag      900

agttcaggct ccagggcatc tctgccaaag gtctcctatg taaaagcgat tgacatctgg      960

atggcggtgt gccttctgtt tgtgtttgct gccttactgg aatacgcagc ggtgaacttc     1020

gtctccaggc aacacaagga gttcctgcgc ctccgaagaa gacagaagag gcagaataag     1080

gaagaagacg ttactcgtga aagtcgtttt aattttagcg gttatgggat gggtcactgc     1140

ctccaagtga aagatggaac agctgtcaag gccacacctg ccaacccact cccacaaccg     1200

ccaaaagatg gagatgctat caagaagaag tttgtggacc gggcaaaaag gattgacacg     1260

atatctcgag ctgccttccc attggccttc ctcattttca acatctttta ctggatcaca     1320

tacaagatca ttcggcatga agatgtccac aagaaatag                            1359


<210>  83
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Asn Arg Gln Leu Val Asn Ile Leu Thr Ala Leu Phe Ala Phe Phe 
1               5                   10                  15      


Leu Glu Thr Asn His Phe Arg Thr Ala Phe Cys Lys Asp His Asp Ser 
            20                  25                  30          


Arg Ser Gly Lys Gln Pro Ser Gln Thr Leu Ser Pro Ser Asp Phe Leu 
        35                  40                  45              


Asp Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro 
    50                  55                  60                  


Asn Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn 
65                  70                  75                  80  


Ser Phe Gly Ser Val Thr Glu Thr Thr Met Asp Tyr Arg Val Asn Ile 
                85                  90                  95      


Phe Leu Arg Gln Gln Trp Asn Asp Ser Arg Leu Ala Tyr Ser Glu Tyr 
            100                 105                 110         


Pro Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp 
        115                 120                 125             


Lys Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Asp 
    130                 135                 140                 


Val Thr Thr Asp Asn Lys Leu Leu Arg Ile Ser Lys Asn Gly Lys Val 
145                 150                 155                 160 


Leu Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu 
                165                 170                 175     


Lys Asn Phe Pro Met Asp Val Gln Thr Cys Thr Met Gln Leu Glu Ser 
            180                 185                 190         


Phe Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Leu Ser Asp Gly 
        195                 200                 205             


Pro Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Ile Leu Lys 
    210                 215                 220                 


Glu Glu Lys Glu Leu Gly Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys 
225                 230                 235                 240 


Phe Thr Cys Ile Glu Val Lys Phe His Leu Glu Arg Gln Met Gly Tyr 
                245                 250                 255     


Tyr Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser 
            260                 265                 270         


Trp Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala 
        275                 280                 285             


Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser 
    290                 295                 300                 


Arg Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp 
305                 310                 315                 320 


Met Ala Val Cys Leu Leu Phe Val Phe Ala Ala Leu Leu Glu Tyr Ala 
                325                 330                 335     


Ala Val Asn Phe Val Ser Arg Gln His Lys Glu Phe Leu Arg Leu Arg 
            340                 345                 350         


Arg Arg Gln Lys Arg Gln Asn Lys Glu Glu Asp Val Thr Arg Glu Ser 
        355                 360                 365             


Arg Phe Asn Phe Ser Gly Tyr Gly Met Gly His Cys Leu Gln Val Lys 
    370                 375                 380                 


Asp Gly Thr Ala Val Lys Ala Thr Pro Ala Asn Pro Leu Pro Gln Pro 
385                 390                 395                 400 


Pro Lys Asp Gly Asp Ala Ile Lys Lys Lys Phe Val Asp Arg Ala Lys 
                405                 410                 415     


Arg Ile Asp Thr Ile Ser Arg Ala Ala Phe Pro Leu Ala Phe Leu Ile 
            420                 425                 430         


Phe Asn Ile Phe Tyr Trp Ile Thr Tyr Lys Ile Ile Arg His Glu Asp 
        435                 440                 445             


Val His Lys Lys 
    450         


<210>  84
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  84
atggcccacg tgagacactt tcggacatta gtttcgggat tttacttctg ggaagcagca       60

ctgttactca gtttggttgc cacaaaggaa acagacagtg caagatctcg aagtgctcca      120

atgtcacctt ctgattttct ggataaatta atgggcagga catcaggata tgatgcaaga      180

atcagaccca attttaaagg ccctccagtt aatgtcacat gcaacatatt catcaacagc      240

tttggctcta tcgcagagac gaccatggat tacagagtga atatctttct tcgtcagaaa      300

tggaatgatc cccgcctcgc gtacagtgaa tatcctgacg actctttaga cctcgacccc      360

tccatgttgg actccatttg gaaacctgat ttgttctttg ccaatgaaaa gggtgccaac      420

tttcatgaag tcactacaga caacaaattg ctaagaattt tcaaaaatgg aaatgttctt      480

tattcaataa gattaacatt aacactttcc tgtccaatgg atctcaagaa ttttcccatg      540

gatgtacaaa catgtataat gcaactggaa agctttgggt acacaatgaa tgatctcatt      600

tttgaatggc aagatgaggc acccgtacaa gtggcagaag gactcacttt gccccagttt      660

ctgttgaaag aagaaaaaga tttacgatac tgcactaaac attacaatac aggaaagttt      720

acgtgtatag aagtgcgatt ccatctggag cgacaaatgg gatactatct gatccagatg      780

tacattccca gtctcctgat tgttattcta tcctgggttt cattctggat caacatggat      840

gcagcaccgg ccagggtagc tctggggata accactgtgc taacgatgac tacacagagt      900

tcaggatcac gagcttcctt gccaaaagtt tcatatgtca aagctattga tatttggatg      960

gcagtatgcc tcctttttgt gttttcagca cttctggagt atgcagctgt aaattttgta     1020

tcaagacaac acaaagaact tctgagattt cgacgaaaga gaaagaataa gacagaagct     1080

tttgcactgg agaagtttta ccgtttctca gatatggatg atgaggtaag ggaaagccga     1140

ttcagcttca cagcctatgg aatgggacca tgtctacaag caaaggatgg catgactcca     1200

aagggcccca accaccctgt ccaggtaatg ccaaaaagtc ctgatgaaat gaggaaggtc     1260

tttatcgacc gggccaagaa gattgatacc atctcccgag cctgcttccc attagctttt     1320

ttgattttta atattttcta ctgggttatc tataaaattc ttaggcatga ggatattcat     1380

cagcagcaag attaa                                                      1395


<210>  85
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ala His Val Arg His Phe Arg Thr Leu Val Ser Gly Phe Tyr Phe 
1               5                   10                  15      


Trp Glu Ala Ala Leu Leu Leu Ser Leu Val Ala Thr Lys Glu Thr Asp 
            20                  25                  30          


Ser Ala Arg Ser Arg Ser Ala Pro Met Ser Pro Ser Asp Phe Leu Asp 
        35                  40                  45              


Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn 
    50                  55                  60                  


Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn Ser 
65                  70                  75                  80  


Phe Gly Ser Ile Ala Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe 
                85                  90                  95      


Leu Arg Gln Lys Trp Asn Asp Pro Arg Leu Ala Tyr Ser Glu Tyr Pro 
            100                 105                 110         


Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys 
        115                 120                 125             


Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Glu Val 
    130                 135                 140                 


Thr Thr Asp Asn Lys Leu Leu Arg Ile Phe Lys Asn Gly Asn Val Leu 
145                 150                 155                 160 


Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu Lys 
                165                 170                 175     


Asn Phe Pro Met Asp Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe 
            180                 185                 190         


Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Gln Asp Glu Ala Pro 
        195                 200                 205             


Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Leu Leu Lys Glu 
    210                 215                 220                 


Glu Lys Asp Leu Arg Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe 
225                 230                 235                 240 


Thr Cys Ile Glu Val Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr 
                245                 250                 255     


Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg 
    290                 295                 300                 


Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met 
305                 310                 315                 320 


Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala 
                325                 330                 335     


Val Asn Phe Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg 
            340                 345                 350         


Lys Arg Lys Asn Lys Thr Glu Ala Phe Ala Leu Glu Lys Phe Tyr Arg 
        355                 360                 365             


Phe Ser Asp Met Asp Asp Glu Val Arg Glu Ser Arg Phe Ser Phe Thr 
    370                 375                 380                 


Ala Tyr Gly Met Gly Pro Cys Leu Gln Ala Lys Asp Gly Met Thr Pro 
385                 390                 395                 400 


Lys Gly Pro Asn His Pro Val Gln Val Met Pro Lys Ser Pro Asp Glu 
                405                 410                 415     


Met Arg Lys Val Phe Ile Asp Arg Ala Lys Lys Ile Asp Thr Ile Ser 
            420                 425                 430         


Arg Ala Cys Phe Pro Leu Ala Phe Leu Ile Phe Asn Ile Phe Tyr Trp 
        435                 440                 445             


Val Ile Tyr Lys Ile Leu Arg His Glu Asp Ile His Gln Gln Gln Asp 
    450                 455                 460                 


<210>  86
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  86
atggcccacg tgagacactt tcggacatta gtttcgggat tttacttctg ggaagcagca       60

ctgttactca gtttggttgc cacaaaggaa acagacagtg caagatctcg aagtgctcca      120

atgtcacctt ctgattttct ggataaatta atgggcagga catcaggata tgatgcaaga      180

atcagaccca attttaaagg ccctccagtt aatgtcacat gcaacatatt catcaacagc      240

tttggctcta tcgcagagac gaccatggat tacagagtga atatctttct tcgtcagaaa      300

tggaatgatc cccgcctcgc gtacagtgaa tatcctgacg actctttaga cctcgacccc      360

tccatgttgg actccatttg gaaacctgat ttgttctttg ccaatgaaaa gggtgccaac      420

tttcatgaag tcactacaga caacaaattg ctaagaattt tcaaaaatgg aaatgttctt      480

tattcaataa gattaacatt aacactttcc tgtccaatgg atctcaagaa ttttcccatg      540

gatgtacaaa catgtataat gcaactggaa agctttgggt acacaatgaa tgatctcatt      600

tttgaatggc aagatgaggc acccgtacaa gtggcagaag gactcacttt gccccagttt      660

ctgttgaaag aagaaaaaga tttacgatac tgcactaaac attacaatac aggaaagttt      720

acgtgtatag aagtgcgatt ccatctggag cgacaaatgg gatactatct gatccagatg      780

tacattccca gtctcctgat tgttattcta tcctgggttt cattctggat caacatggat      840

gcagcaccgg ccagggtagc tctggggata accactgtgc taacgatgac tacacagagt      900

tcaggatcac gagcttcctt gccaaaagtt tcatatgtca aagctattga tatttggatg      960

gcagtatgcc tcctttttgt gttttcagca cttctggagt atgcagctgt aaattttgta     1020

tcaagacaac acaaagaact tctgagattt cgacgaaaga gaaagaataa ggatgatgag     1080

gtaagggaaa gccgattcag cttcacagcc tatggaatgg gaccatgtct acaagcaaag     1140

gatggcatga ctccaaaggg ccccaaccac cctgtccagg taatgccaaa aagtcctgat     1200

gaaatgagga aggtctttat cgaccgggcc aagaagattg ataccatctc ccgagcctgc     1260

ttcccattag cttttttgat ttttaatatt ttctactggg ttatctataa aattcttagg     1320

catgaggata ttcatcagca gcaagattaa                                      1350


<210>  87
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala His Val Arg His Phe Arg Thr Leu Val Ser Gly Phe Tyr Phe 
1               5                   10                  15      


Trp Glu Ala Ala Leu Leu Leu Ser Leu Val Ala Thr Lys Glu Thr Asp 
            20                  25                  30          


Ser Ala Arg Ser Arg Ser Ala Pro Met Ser Pro Ser Asp Phe Leu Asp 
        35                  40                  45              


Lys Leu Met Gly Arg Thr Ser Gly Tyr Asp Ala Arg Ile Arg Pro Asn 
    50                  55                  60                  


Phe Lys Gly Pro Pro Val Asn Val Thr Cys Asn Ile Phe Ile Asn Ser 
65                  70                  75                  80  


Phe Gly Ser Ile Ala Glu Thr Thr Met Asp Tyr Arg Val Asn Ile Phe 
                85                  90                  95      


Leu Arg Gln Lys Trp Asn Asp Pro Arg Leu Ala Tyr Ser Glu Tyr Pro 
            100                 105                 110         


Asp Asp Ser Leu Asp Leu Asp Pro Ser Met Leu Asp Ser Ile Trp Lys 
        115                 120                 125             


Pro Asp Leu Phe Phe Ala Asn Glu Lys Gly Ala Asn Phe His Glu Val 
    130                 135                 140                 


Thr Thr Asp Asn Lys Leu Leu Arg Ile Phe Lys Asn Gly Asn Val Leu 
145                 150                 155                 160 


Tyr Ser Ile Arg Leu Thr Leu Thr Leu Ser Cys Pro Met Asp Leu Lys 
                165                 170                 175     


Asn Phe Pro Met Asp Val Gln Thr Cys Ile Met Gln Leu Glu Ser Phe 
            180                 185                 190         


Gly Tyr Thr Met Asn Asp Leu Ile Phe Glu Trp Gln Asp Glu Ala Pro 
        195                 200                 205             


Val Gln Val Ala Glu Gly Leu Thr Leu Pro Gln Phe Leu Leu Lys Glu 
    210                 215                 220                 


Glu Lys Asp Leu Arg Tyr Cys Thr Lys His Tyr Asn Thr Gly Lys Phe 
225                 230                 235                 240 


Thr Cys Ile Glu Val Arg Phe His Leu Glu Arg Gln Met Gly Tyr Tyr 
                245                 250                 255     


Leu Ile Gln Met Tyr Ile Pro Ser Leu Leu Ile Val Ile Leu Ser Trp 
            260                 265                 270         


Val Ser Phe Trp Ile Asn Met Asp Ala Ala Pro Ala Arg Val Ala Leu 
        275                 280                 285             


Gly Ile Thr Thr Val Leu Thr Met Thr Thr Gln Ser Ser Gly Ser Arg 
    290                 295                 300                 


Ala Ser Leu Pro Lys Val Ser Tyr Val Lys Ala Ile Asp Ile Trp Met 
305                 310                 315                 320 


Ala Val Cys Leu Leu Phe Val Phe Ser Ala Leu Leu Glu Tyr Ala Ala 
                325                 330                 335     


Val Asn Phe Val Ser Arg Gln His Lys Glu Leu Leu Arg Phe Arg Arg 
            340                 345                 350         


Lys Arg Lys Asn Lys Asp Asp Glu Val Arg Glu Ser Arg Phe Ser Phe 
        355                 360                 365             


Thr Ala Tyr Gly Met Gly Pro Cys Leu Gln Ala Lys Asp Gly Met Thr 
    370                 375                 380                 


Pro Lys Gly Pro Asn His Pro Val Gln Val Met Pro Lys Ser Pro Asp 
385                 390                 395                 400 


Glu Met Arg Lys Val Phe Ile Asp Arg Ala Lys Lys Ile Asp Thr Ile 
                405                 410                 415     


Ser Arg Ala Cys Phe Pro Leu Ala Phe Leu Ile Phe Asn Ile Phe Tyr 
            420                 425                 430         


Trp Val Ile Tyr Lys Ile Leu Arg His Glu Asp Ile His Gln Gln Gln 
        435                 440                 445             


Asp 
    


<210>  88
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence of chimeric LGIC

<400>  88

Met Arg Cys Ser Pro Gly Gly Val Trp Leu Ala Leu Ala Ala Ser Leu 
1               5                   10                  15      


Leu His Val Ser Leu Gln Gly Glu Phe Gln Arg Lys Leu Tyr Lys Glu 
            20                  25                  30          


Leu Val Lys Asn Tyr Asn Pro Leu Glu Arg Pro Val Ala Asn Asp Ser 
        35                  40                  45              


Gln Pro Leu Thr Val Tyr Phe Ser Leu Ser Leu Leu Gln Ile Met Asp 
    50                  55                  60                  


Val Asp Glu Lys Asn Gln Val Leu Thr Thr Asn Ile Trp Leu Gln Met 
65                  70                  75                  80  


Ser Trp Thr Asp His Tyr Leu Gln Trp Asn Val Ser Glu Tyr Pro Gly 
                85                  90                  95      


Val Lys Thr Val Arg Phe Pro Asp Gly Gln Ile Trp Lys Pro Asp Ile 
            100                 105                 110         


Leu Leu Tyr Asn Ser Ala Asp Glu Arg Phe Asp Ala Thr Phe His Thr 
        115                 120                 125             


Asn Val Leu Val Asn Ser Ser Gly His Cys Gln Cys Leu Pro Pro Gly 
    130                 135                 140                 


Ile Phe Lys Ser Ser Cys Pro Met Asp Leu Lys Asn Phe Pro Met Asp 
145                 150                 155                 160 


Val Gln Thr Cys Lys Leu Lys Phe Gly Ser Trp Ser Tyr Gly Gly Trp 
                165                 170                 175     


Ser Leu Asp Leu Gln Met Gln Glu Ala Asp Ile Ser Gly Tyr Ile Pro 
            180                 185                 190         


Asn Gly Glu Trp Asp Leu Val Gly Ile Pro Gly Lys Arg Ser Glu Arg 
        195                 200                 205             


Phe Tyr Glu Cys Cys Lys Glu Pro Tyr Pro Asp Val Thr Phe Thr Val 
    210                 215                 220                 


Thr Met Arg Arg Arg Met Gly Tyr Tyr Leu Ile Gln Met Tyr Ile Pro 
225                 230                 235                 240 


Ser Leu Leu Ile Val Ile Leu Ser Trp Ile Ser Phe Trp Ile Asn Met 
                245                 250                 255     


Asp Ala Ala Pro Ala Arg Val Gly Leu Gly Ile Thr Thr Val Leu Thr 
            260                 265                 270         


Met Thr Thr Gln Ser Ser Gly Ser Arg Ala Ser Leu Pro Lys Val Ser 
        275                 280                 285             


Tyr Val Lys Ala Ile Asp Ile Trp Met Ala Val Cys Leu Leu Phe Val 
    290                 295                 300                 


Phe Ser Ala Leu Leu Glu Tyr Ala Ala Val Asn Phe Val Ser Arg Gln 
305                 310                 315                 320 


His Lys Glu Leu Leu Arg Phe Arg Arg Lys Arg Arg His His Lys Ser 
                325                 330                 335     


Pro Met Leu Asn Leu Phe Gln Glu Asp Glu Ala Gly Glu Gly Arg Phe 
            340                 345                 350         


Asn Phe Ser Ala Tyr Gly Met Gly Pro Ala Cys Leu Gln Ala Lys Asp 
        355                 360                 365             


Gly Ile Ser Val Lys Gly Ala Asn Asn Ser Asn Thr Thr Asn Pro Pro 
    370                 375                 380                 


Pro Ala Pro Ser Lys Ser Pro Glu Glu Met Arg Lys Leu Phe Ile Gln 
385                 390                 395                 400 


Arg Ala Lys Lys Ile Asp Lys Ile Ser Arg Ile Gly Phe Pro Met Ala 
                405                 410                 415     


Phe Leu Ile Phe Asn Met Phe Tyr Trp Ile Ile Tyr Lys Ile Val Arg 
            420                 425                 430         


Arg Glu Asp Val His Asn Gln 
        435                 


