                         SEQUENCE LISTING

<110>  QUELL THERAPEUTICS LTD
 
<120>  NUCLEIC ACID CONSTRUCTS FOR EXPRESSING POLYPEPTIDES IN CELLS

<130>  27.130.150139/01

<150>  GB2013477.1
<151>  2020-08-27

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RQR8

<400>  1

Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
            20                  25                  30          


Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser Asn Pro Ser Leu 
        35                  40                  45              


Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    50                  55                  60                  


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
65                  70                  75                  80  


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                85                  90                  95      


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            100                 105                 110         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
        115                 120                 125             


Val Cys Lys Cys Pro Arg Pro Val Val 
    130                 135         


<210>  2
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3, UniProtKB accession Q9BZS1

<400>  2

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  3
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3, aa418 mutant

<400>  3

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Glu Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  4
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3, aa422 mutant

<400>  4

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ala Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  5
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3, aa 418 and 422 mutant

<400>  5

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Glu Gln Arg Pro Ala Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  6
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3, truncated variant

<400>  6

Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met Pro Pro Ser 
1               5                   10                  15      


Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala Pro Ser Gly 
            20                  25                  30          


Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu Gln Asp Arg 
        35                  40                  45              


Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His Ala Arg Thr 
    50                  55                  60                  


Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met Ile Ser Leu 
65                  70                  75                  80  


Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys Ala Arg Pro 
                85                  90                  95      


Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp Val Ser Arg 
            100                 105                 110         


Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala Pro Arg Lys 
        115                 120                 125             


Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro Leu Leu Ala 
    130                 135                 140                 


Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe Glu Glu Pro 
145                 150                 155                 160 


Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu Asp Glu Lys 
                165                 170                 175     


Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln Ser Leu Glu 
            180                 185                 190         


Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met Gln Ala His 
        195                 200                 205             


Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala Ser Ser 
    210                 215                 220                 


Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly Pro Val 
225                 230                 235                 240 


Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala 
                245                 250                 255     


Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe Pro Glu 
            260                 265                 270         


Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg Pro Pro 
        275                 280                 285             


Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu 
    290                 295                 300                 


Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr Arg Met Phe 
305                 310                 315                 320 


Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala Ile Arg His 
                325                 330                 335     


Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser Glu Lys Gly 
            340                 345                 350         


Ala Val Trp Thr Val Asp Glu Leu Glu Phe 
        355                 360         


<210>  7
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FOXP3, illustrative variant

<400>  7

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Val Glu Glu Leu Ser Ala Met Gln Ala His Leu Ala 
                245                 250                 255     


Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala Ser Ser Asp Lys 
            260                 265                 270         


Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly Pro Val Val Pro 
        275                 280                 285             


Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala Val Arg 
    290                 295                 300                 


Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe Pro Glu Phe Leu 
305                 310                 315                 320 


His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg Pro Pro Phe Thr 
                325                 330                 335     


Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu Lys Gln 
            340                 345                 350         


Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr Arg Met Phe Ala Phe 
        355                 360                 365             


Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala Ile Arg His Asn Leu 
    370                 375                 380                 


Ser Leu His Lys Cys Phe Val Arg Val Glu Ser Glu Lys Gly Ala Val 
385                 390                 395                 400 


Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys Arg Ser Gln Arg Pro 
                405                 410                 415     


Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro Glu Gly Arg Gly Ser Leu 
            420                 425                 430         


Leu Thr Cys Gly Asp Val Glu Glu Asn 
        435                 440     


<210>  8
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXP3, Illustrative FOXP3 polynucleotide

<400>  8
atgcccaacc ccaggcctgg caagccctcg gccccttcct tggcccttgg cccatcccca       60

ggagcctcgc ccagctggag ggctgcaccc aaagcctcag acctgctggg ggcccggggc      120

ccagggggaa ccttccaggg ccgagatctt cgaggcgggg cccatgcctc ctcttcttcc      180

ttgaacccca tgccaccatc gcagctgcag ctgcccacac tgcccctagt catggtggca      240

ccctccgggg cacggctggg ccccttgccc cacttacagg cactcctcca ggacaggcca      300

catttcatgc accagctctc aacggtggat gcccacgccc ggacccctgt gctgcaggtg      360

caccccctgg agagcccagc catgatcagc ctcacaccac ccaccaccgc cactggggtc      420

ttctccctca aggcccggcc tggcctccca cctgggatca acgtggccag cctggaatgg      480

gtgtccaggg agccggcact gctctgcacc ttcccaaatc ccagtgcacc caggaaggac      540

agcacccttt cggctgtgcc ccagagctcc tacccactgc tggcaaatgg tgtctgcaag      600

tggcccggat gtgagaaggt cttcgaagag ccagaggact tcctcaagca ctgccaggcg      660

gaccatcttc tggatgagaa gggcagggca caatgtctcc tccagagaga gatggtacag      720

tctctggagc agcagctggt gctggagaag gagaagctga gtgccatgca ggcccacctg      780

gctgggaaaa tggcactgac caaggcttca tctgtggcat catccgacaa gggctcctgc      840

tgcatcgtag ctgctggcag ccaaggccct gtcgtcccag cctggtctgg cccccgggag      900

gcccctgaca gcctgtttgc tgtccggagg cacctgtggg gtagccatgg aaacagcaca      960

ttcccagagt tcctccacaa catggactac ttcaagttcc acaacatgcg accccctttc     1020

acctacgcca cgctcatccg ctgggccatc ctggaggctc cagagaagca gcggacactc     1080

aatgagatct accactggtt cacacgcatg tttgccttct tcagaaacca tcctgccacc     1140

tggaagaacg ccatccgcca caacctgagt ctgcacaagt gctttgtgcg ggtggagagc     1200

gagaaggggg ctgtgtggac cgtggatgag ctggagttcc gcaagaaacg gagccagagg     1260

cccagcaggt gttccaaccc tacacctggc ccctga                               1296


<210>  9
<211>  1352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOXP3, Illustrative FOXP3 polynucleotide

<400>  9
gaattcgtcg acatgcccaa ccccagaccc ggcaagcctt ctgccccttc tctggccctg       60

ggaccatctc ctggcgcctc cccatcttgg agagccgccc ctaaagccag cgatctgctg      120

ggagctagag gccctggcgg cacattccag ggcagagatc tgagaggcgg agcccacgcc      180

tctagcagca gcctgaatcc catgccccct agccagctgc agctgcctac actgcctctc      240

gtgatggtgg cccctagcgg agctagactg ggccctctgc ctcatctgca ggctctgctg      300

caggaccggc cccactttat gcaccagctg agcaccgtgg acgcccacgc cagaacacct      360

gtgctgcagg tgcaccccct ggaaagccct gccatgatca gcctgacccc tccaaccaca      420

gccaccggcg tgttcagcct gaaggccaga cctggactgc cccctggcat caatgtggcc      480

agcctggaat gggtgtcccg cgaacctgcc ctgctgtgca ccttccccaa tcctagcgcc      540

cccagaaagg acagcacact gtctgccgtg ccccagagca gctatcccct gctggctaac      600

ggcgtgtgca agtggcctgg ctgcgagaag gtgttcgagg aacccgagga cttcctgaag      660

cactgccagg ccgaccatct gctggacgag aaaggcagag cccagtgcct gctgcagcgc      720

gagatggtgc agtccctgga acagcagctg gtgctggaaa aagaaaagct gagcgccatg      780

caggcccacc tggccggaaa gatggccctg acaaaagcca gcagcgtggc cagctccgac      840

aagggcagct gttgtatcgt ggccgctggc agccagggac ctgtggtgcc tgcttggagc      900

ggacctagag aggcccccga tagcctgttt gccgtgcgga gacacctgtg gggcagccac      960

ggcaactcta ccttccccga gttcctgcac aacatggact acttcaagtt ccacaacatg     1020

aggcccccct tcacctacgc caccctgatc agatgggcca ttctggaagc ccccgagaag     1080

cagcggaccc tgaacgagat ctaccactgg tttacccgga tgttcgcctt cttccggaac     1140

caccccgcca cctggaagaa cgccatccgg cacaatctga gcctgcacaa gtgcttcgtg     1200

cgggtggaaa gcgagaaggg cgccgtgtgg acagtggacg agctggaatt tcggaagaag     1260

cggtcccaga ggcccagccg gtgtagcaat cctacacctg gccctgaggg cagaggaagt     1320

ctgctaacat gcggtgacgt cgaggagaat cc                                   1352


<210>  10
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RQR8 with signal peptide

<400>  10

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
145                 150                 155         


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR1

<400>  11

Asp Tyr Gly Met His 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR2

<400>  12

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR3

<400>  13

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR1

<400>  14

Gln Ser Ser Leu Asp Ile Ser His Tyr Leu Asn 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR2

<400>  15

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR3

<400>  16

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  17
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 3PB2

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL 3PB2

<400>  18

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv 3PB2


<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  Xaa represents X(n), wherein X is any 

       amino acid and n is 15-25

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Xaa Asp Val Val Met Thr Gln Ser Pro Ser Ser 
        115                 120                 125             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
    130                 135                 140                 


Leu Asp Ile Ser His Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
145                 150                 155                 160 


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
                165                 170                 175     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Phe Thr 
            180                 185                 190         


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
        195                 200                 205             


Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    210                 215                 220                 


Lys 
225 


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR1

<400>  20

Asp Tyr Gly Met His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR2

<400>  21

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR3

<400>  22

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 VL CDR1

<400>  23

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 VL CDR2

<400>  24

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 VH CDR3

<400>  25

Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
1               5                   


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH 3PF12

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  27
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL B11

<400>  27

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  28
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFv

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
            180                 185                 190         


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Gly 
                245     


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide - cleavage domain

<400>  29

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A  peptide - cleavage domain

<400>  30

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide - cleavage domain

<400>  31

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  32
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide - cleavage domain

<400>  32

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab binding epitope from CD20

<400>  33

Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser Pro Ser Thr Gln Tyr 
1               5                   10                  15      


Cys 
    


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  34

Ala Cys Pro Tyr Ala Asn Pro Ser Leu Cys 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  35

Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  36

Ala Cys Pro Phe Ala Asn Pro Ser Thr Cys 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  37

Ala Cys Asn Phe Ser Asn Pro Ser Leu Cys 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  38

Ala Cys Pro Phe Ser Asn Pro Ser Met Cys 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  39

Ala Cys Ser Trp Ala Asn Pro Ser Gln Cys 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  40

Ala Cys Met Phe Ser Asn Pro Ser Leu Cys 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  41

Ala Cys Pro Phe Ala Asn Pro Ser Met Cys 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  42

Ala Cys Trp Ala Ser Asn Pro Ser Leu Cys 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  43

Ala Cys Glu His Ser Asn Pro Ser Leu Cys 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  44

Ala Cys Trp Ala Ala Asn Pro Ser Met Cys 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  45

Cys Pro Tyr Ala Asn Pro Ser Leu Cys 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  46

Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  47

Cys Pro Phe Ala Asn Pro Ser Thr Cys 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  48

Cys Asn Phe Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  49

Cys Pro Phe Ser Asn Pro Ser Met Cys 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  50

Cys Ser Trp Ala Asn Pro Ser Gln Cys 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  51

Cys Met Phe Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  52

Cys Pro Phe Ala Asn Pro Ser Met Cys 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  53

Cys Trp Ala Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  54

Cys Glu His Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab mimotope

<400>  55

Cys Trp Ala Ala Asn Pro Ser Met Cys 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Circular Rituximab mimotope consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be Ala or Ser

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Xaa Cys Xaa Xaa Xaa Asn Pro Ser Xaa Cys 
1               5                   10  


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-circular Rituximab mimotope

<400>  57

Gln Asp Lys Leu Thr Gln Trp Pro Lys Trp Leu Glu 
1               5                   10          


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QBend epitope sequence

<400>  58

Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


<210>  59
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 extracellular Stalk sequence

<400>  59

Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
1               5                   10                  15      


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
            20                  25                  30          


His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40          


<210>  60
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 stalk, extracellular, TM and intracellular

<400>  60

Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
1               5                   10                  15      


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
            20                  25                  30          


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
        35                  40                  45              


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
    50                  55                  60                  


Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro 
65                  70                  75                  80  


Val Val 
        


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  61

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  62

Ser Gly Gly Gly Ser 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker domain

<400>  63

Gly Gly Gly Gly Ser 
1               5   


<210>  64
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-Q-S2 linker sequence from RQR8

<400>  64

Ser Gly Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn 
1               5                   10                  15      


Val Ser Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala 
            20                  25                  30  


<210>  65
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide (safety switch polypeptide)

<400>  65

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp 
            20  


<210>  66
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader/signal sequence for CAR (modified CD8a leader)

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Ala Pro 
            20      


<210>  67
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a TM domain

<400>  67

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  68
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified CD8a hinge plus CD8a TM domain for CAR

<400>  68

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
    50                  55                  60                  


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
65                  70                  75                  80  


Arg 
    


<210>  69
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified CD8a hinge

<400>  69

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Asp 
    50                  


<210>  70
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type CD8a hinge

<400>  70

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg 
        


<210>  71
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 endodomain (2AA Transmembrane  - WV)

<400>  71

Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
1               5                   10                  15      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            20                  25                  30          


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40              


<210>  72
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3? endodomain 1AA deletion compared to WT

<400>  72

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


Ser Gln Leu 
        115 


<210>  73
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane domain

<400>  73

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  74
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge and transmembrane

<400>  74

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  75
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild type CD8a leader/signal sequence

<400>  75

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  76
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT hCD3? endodomain

<400>  76

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  77
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT CD28 endodomain

<400>  77

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  78
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 signalling domain

<400>  78

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  79
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB signalling domain

<400>  79

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  80
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS signalling domain

<400>  80

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  81
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF25 signalling domain

<400>  81

Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210>  82
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  82

Arg Xaa Xaa Arg 
1               


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  83

Arg Arg Lys Arg 
1               


<210>  84
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB

<400>  84

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  85
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB truncated - Y510

<400>  85

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  86
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL2RB truncated - Y510 & Y392

<400>  86

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Asp Ala Tyr Cys Thr Phe Pro Ser 
65                  70                  75                  80  


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser 
                85                  90                  95      


Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met 
            100                 105                 110         


Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro 
        115                 120                 125             


Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro 
    130                 135                 140                 


Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala 
145                 150                 155                 160 


Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln 
                165                 170                 175     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            180                 185                 190         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205             


<210>  87
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SFFV promoter

<400>  87

Gly Thr Ala Ala Cys Gly Cys Cys Ala Thr Thr Thr Thr Gly Cys Ala 
1               5                   10                  15      


Ala Gly Gly Cys Ala Thr Gly Gly Ala Ala Ala Ala Ala Thr Ala Cys 
            20                  25                  30          


Cys Ala Ala Ala Cys Cys Ala Ala Gly Ala Ala Thr Ala Gly Ala Gly 
        35                  40                  45              


Ala Ala Gly Thr Thr Cys Ala Gly Ala Thr Cys Ala Ala Gly Gly Gly 
    50                  55                  60                  


Cys Gly Gly Gly Thr Ala Cys Ala Thr Gly Ala Ala Ala Ala Thr Ala 
65                  70                  75                  80  


Gly Cys Thr Ala Ala Cys Gly Thr Thr Gly Gly Gly Cys Cys Ala Ala 
                85                  90                  95      


Ala Cys Ala Gly Gly Ala Thr Ala Thr Cys Thr Gly Cys Gly Gly Thr 
            100                 105                 110         


Gly Ala Gly Cys Ala Gly Thr Thr Thr Cys Gly Gly Cys Cys Cys Cys 
        115                 120                 125             


Gly Gly Cys Cys Cys Gly Gly Gly Gly Cys Cys Ala Ala Gly Ala Ala 
    130                 135                 140                 


Cys Ala Gly Ala Thr Gly Gly Thr Cys Ala Cys Cys Gly Cys Ala Gly 
145                 150                 155                 160 


Thr Thr Thr Cys Gly Gly Cys Cys Cys Cys Gly Gly Cys Cys Cys Gly 
                165                 170                 175     


Ala Gly Gly Cys Cys Ala Ala Gly Ala Ala Cys Ala Gly Ala Thr Gly 
            180                 185                 190         


Gly Thr Cys Cys Cys Cys Ala Gly Ala Thr Ala Thr Gly Gly Cys Cys 
        195                 200                 205             


Cys Ala Ala Cys Cys Cys Thr Cys Ala Gly Cys Ala Gly Thr Thr Thr 
    210                 215                 220                 


Cys Thr Thr Ala Ala Gly Ala Cys Cys Cys Ala Thr Cys Ala Gly Ala 
225                 230                 235                 240 


Thr Gly Thr Thr Thr Cys Cys Ala Gly Gly Cys Thr Cys Cys Cys Cys 
                245                 250                 255     


Cys Ala Ala Gly Gly Ala Cys Cys Thr Gly Ala Ala Ala Thr Gly Ala 
            260                 265                 270         


Cys Cys Cys Thr Gly Cys Gly Cys Cys Thr Thr Ala Thr Thr Thr Gly 
        275                 280                 285             


Ala Ala Thr Thr Ala Ala Cys Cys Ala Ala Thr Cys Ala Gly Cys Cys 
    290                 295                 300                 


Thr Gly Cys Thr Thr Cys Thr Cys Gly Cys Thr Thr Cys Thr Gly Thr 
305                 310                 315                 320 


Thr Cys Gly Cys Gly Cys Gly Cys Thr Thr Cys Thr Gly Cys Thr Thr 
                325                 330                 335     


Cys Cys Cys Gly Ala Gly Cys Thr Cys Thr Ala Thr Ala Ala Ala Ala 
            340                 345                 350         


Gly Ala Gly Cys Thr Cys Ala Cys Ala Ala Cys Cys Cys Cys Thr Cys 
        355                 360                 365             


Ala Cys Thr Cys Gly Gly Cys Gly Cys Gly Cys Cys Ala Gly Thr Cys 
    370                 375                 380                 


Cys Thr Cys Cys Gly Ala Cys Ala Gly Ala Cys Thr Gly Ala Gly Thr 
385                 390                 395                 400 


Cys Gly Gly Cys Cys Gly Gly 
                405         


<210>  88
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 scFv

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Val Val Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  89
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  89

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Thr 
            20          


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Small SGGGGS linker

<400>  90

Glu Thr Ser Gly Gly Gly Gly Ser Arg Leu 
1               5                   10  


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Big SGGGGS linker

<400>  91

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  92
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Safety switch polypeptide

<400>  92

Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Glu Thr Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Arg Leu Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        35                  40                  45              


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    50                  55                  60                  


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
65                  70                  75                  80  


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                85                  90                  95      


Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys 
            100                 105                 110         


Pro Arg Pro Val Val 
        115         


<210>  93
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Safety switch polypeptide

<400>  93

Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Tyr Ser Asn Pro 
            20                  25                  30          


Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr 
        35                  40                  45              


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    50                  55                  60                  


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
65                  70                  75                  80  


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                85                  90                  95      


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg 
            100                 105                 110         


Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
        115                 120             


<210>  94
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide comprising a signal peptide and the amino acid 
       sequence of SEQ ID NO. 92. (1xSGGGGS with leader)

<400>  94

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Glu Thr 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Arg Leu Cys Pro Tyr Ser Asn Pro Ser Leu 
        35                  40                  45              


Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    50                  55                  60                  


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
65                  70                  75                  80  


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                85                  90                  95      


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            100                 105                 110         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
        115                 120                 125             


Val Cys Lys Cys Pro Arg Pro Val Val 
    130                 135         


<210>  95
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide comprising a signal peptide and the amino acid 
       sequence of SEQ ID NO. 93. (3xSGGGGS with leader)

<400>  95

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro 
        35                  40                  45              


Tyr Ser Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro 
    50                  55                  60                  


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
65                  70                  75                  80  


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                85                  90                  95      


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            100                 105                 110         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
        115                 120                 125             


His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
    130                 135                 140             


