                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Self Assembling Protein Nanoparticles as Carrier Molecules

<130>  034044.220

<150>  PCT/US2020/030142
<151>  2020-04-27

<150>  US 62/838,826
<151>  2019-04-25

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  1

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu 
    130                 135                 140                 


Val Trp Cys Thr Cys Gly Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
145                 150                 155                 160 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
                165                 170                 175     


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
            180                 185                 190         


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
        195                 200                 205             


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
    210                 215                 220                 


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
225                 230                 235                 240 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
                245                 250                 255     


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
            260                 265                 270         


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
        275                 280                 285             


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
    290                 295                 300                 


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
305                 310                 315                 320 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
                325                 330                 335     


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
            340                 345                 350         


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
        355                 360                 365             


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
    370                 375                 380                 


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
385                 390                 395                 400 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
                405                 410                 415     


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
            420                 425                 430         


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
        435                 440                 445             


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln 
    450                 455                 460                 


Leu Glu His His His His His His 
465                 470         


<210>  2
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  2

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu 
    130                 135                 140                 


Val Trp Cys Thr Cys Gly Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
145                 150                 155                 160 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
                165                 170                 175     


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
            180                 185                 190         


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
        195                 200                 205             


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
    210                 215                 220                 


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
225                 230                 235                 240 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
                245                 250                 255     


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
            260                 265                 270         


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
        275                 280                 285             


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
    290                 295                 300                 


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
305                 310                 315                 320 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
                325                 330                 335     


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
            340                 345                 350         


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
        355                 360                 365             


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
    370                 375                 380                 


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
385                 390                 395                 400 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
                405                 410                 415     


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
            420                 425                 430         


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
        435                 440                 445             


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Glu Asn Leu Tyr Phe Gln 
    450                 455                 460                 


Gly Leu Glu His His His His His His 
465                 470             


<210>  3
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  3

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  4
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  4

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln Glu Asn Leu Tyr Phe Gln Gly Leu Glu His His His His His 
465                 470                 475                 480 


His 
    


<210>  5
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  5

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu 
    130                 135                 140                 


Val Trp Cys Thr Cys Gly Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
145                 150                 155                 160 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
                165                 170                 175     


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
            180                 185                 190         


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
        195                 200                 205             


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
    210                 215                 220                 


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
225                 230                 235                 240 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
                245                 250                 255     


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
            260                 265                 270         


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
        275                 280                 285             


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
    290                 295                 300                 


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
305                 310                 315                 320 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
                325                 330                 335     


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
            340                 345                 350         


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
        355                 360                 365             


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
    370                 375                 380                 


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
385                 390                 395                 400 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
                405                 410                 415     


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
            420                 425                 430         


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
        435                 440                 445             


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln 
    450                 455                 460                 


Leu Glu His His His His His His 
465                 470         


<210>  6
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  6

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu 
    130                 135                 140                 


Val Trp Cys Thr Cys Gly Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
145                 150                 155                 160 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
                165                 170                 175     


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
            180                 185                 190         


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
        195                 200                 205             


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
    210                 215                 220                 


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
225                 230                 235                 240 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
                245                 250                 255     


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
            260                 265                 270         


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
        275                 280                 285             


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
    290                 295                 300                 


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
305                 310                 315                 320 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
                325                 330                 335     


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
            340                 345                 350         


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
        355                 360                 365             


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
    370                 375                 380                 


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
385                 390                 395                 400 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
                405                 410                 415     


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
            420                 425                 430         


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
        435                 440                 445             


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Glu Asn Leu Tyr Phe Gln 
    450                 455                 460                 


Gly Leu Glu His His His His His His 
465                 470             


<210>  7
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  7

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  8
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  8

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln Glu Asn Leu Tyr Phe Gln Gly Leu Glu His His His His His 
465                 470                 475                 480 


His 
    


<210>  9
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  9

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Arg Trp Gly Cys Asp Cys Ala Trp His Leu 
    130                 135                 140                 


Gly Glu Leu Val Trp Cys Thr Cys Gly Trp Glu Gly Asp Asn Pro Asp 
145                 150                 155                 160 


Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala Val Lys 
                165                 170                 175     


Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn 
            180                 185                 190         


Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val Arg Asn 
        195                 200                 205             


Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala 
    210                 215                 220                 


Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp 
225                 230                 235                 240 


Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu Pro Ile 
                245                 250                 255     


Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala Glu Tyr 
            260                 265                 270         


Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His Ala Glu 
        275                 280                 285             


Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala 
    290                 295                 300                 


Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile 
305                 310                 315                 320 


Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp 
                325                 330                 335     


Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  10
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  10

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Arg Trp Asp Cys Ala Trp His Leu Gly Glu 
    130                 135                 140                 


Leu Val Trp Cys Thr Trp Glu Gly Asp Asn Pro Asp Gly Ala Ala Pro 
145                 150                 155                 160 


Gln Glu Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr 
                165                 170                 175     


Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn 
            180                 185                 190         


Leu Gly Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr 
        195                 200                 205             


Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp 
    210                 215                 220                 


Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu 
225                 230                 235                 240 


Ile Leu His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala 
                245                 250                 255     


Arg Val Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu 
            260                 265                 270         


Gly Ala Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr 
        275                 280                 285             


Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys 
    290                 295                 300                 


Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly 
305                 310                 315                 320 


Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly 
                325                 330                 335     


Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro 
            340                 345                 350         


Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu 
        355                 360                 365             


Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn 
    370                 375                 380                 


Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys 
385                 390                 395                 400 


Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu 
                405                 410                 415     


Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu 
            420                 425                 430         


Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu 
        435                 440                 445             


Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His 
    450                 455                 460                 


Arg Gln Leu Glu His His His His His His 
465                 470                 


<210>  11
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  11

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Gly Arg Trp Asp Cys Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Cys Thr Trp Glu Gly Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  12
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  12

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Gly Arg Trp Asp Ala Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Ala Thr Trp Glu Gly Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  13
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  13

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Ser Gly Ala Asp Cys Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Cys Thr Ala Gly Ser Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  14
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  14

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Gly Gly Gly Ser Gly Ala Asp Ala Ala Trp His 
    130                 135                 140                 


Leu Gly Glu Leu Val Trp Ala Thr Ala Gly Ser Gly Gly Gly Asp Asn 
145                 150                 155                 160 


Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala 
                165                 170                 175     


Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe 
            180                 185                 190         


Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val 
        195                 200                 205             


Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala 
    210                 215                 220                 


Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg 
225                 230                 235                 240 


Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  15
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  15

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Gly Gly Gly Ser Gly Cys Asp Cys Ala 
                245                 250                 255     


Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly 
            260                 265                 270         


Ala Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr 
        275                 280                 285             


His Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala 
    290                 295                 300                 


Gln Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val 
305                 310                 315                 320 


Leu Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg 
                325                 330                 335     


Leu Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met 
            340                 345                 350         


Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile 
        355                 360                 365             


Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln 
    370                 375                 380                 


Arg Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn 
385                 390                 395                 400 


Asn Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile 
                405                 410                 415     


Thr Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala 
            420                 425                 430         


Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr 
        435                 440                 445             


Thr Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala 
    450                 455                 460                 


Asp Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His 
465                 470                 475                 480 


His 
    


<210>  16
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  16

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Gly Gly Gly Ser Gly Cys Asp 
    210                 215                 220                 


Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu 
                245                 250                 255     


Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala 
            260                 265                 270         


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
        275                 280                 285             


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
    290                 295                 300                 


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
305                 310                 315                 320 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
                325                 330                 335     


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
            340                 345                 350         


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
        355                 360                 365             


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
    370                 375                 380                 


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
385                 390                 395                 400 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
                405                 410                 415     


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
            420                 425                 430         


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
        435                 440                 445             


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
    450                 455                 460                 


Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  17
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  17

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Gly Gly Gly Ser Gly 
                165                 170                 175     


Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly 
            180                 185                 190         


Ser Gly Gly Gly Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn 
        195                 200                 205             


Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr 
    210                 215                 220                 


Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala 
225                 230                 235                 240 


Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr 
                245                 250                 255     


Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val 
            260                 265                 270         


Glu Gly Ala Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn 
        275                 280                 285             


Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln 
    290                 295                 300                 


Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser 
305                 310                 315                 320 


Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala 
                325                 330                 335     


Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg 
            340                 345                 350         


Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr 
        355                 360                 365             


Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln 
    370                 375                 380                 


Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val 
385                 390                 395                 400 


Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys 
                405                 410                 415     


Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly 
            420                 425                 430         


Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly 
        435                 440                 445             


Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser 
    450                 455                 460                 


His Arg Gln Leu Glu His His His His His His 
465                 470                 475 


<210>  18
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  18

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp His Leu Gly 
225                 230                 235                 240 


Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly Thr Leu Pro Ile 
                245                 250                 255     


Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala Glu Tyr 
            260                 265                 270         


Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His Ala Glu 
        275                 280                 285             


Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala 
    290                 295                 300                 


Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile 
305                 310                 315                 320 


Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp 
                325                 330                 335     


Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  19
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  19

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val 
        115                 120                 125             


Trp Cys Thr Cys Gly Ser Gly Gly Gly Arg Ile Ala Ala Val Ala Phe 
    130                 135                 140                 


Leu Ala Ser Leu Glu Pro Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp 
145                 150                 155                 160 


Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala Val Lys 
                165                 170                 175     


Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn 
            180                 185                 190         


Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val Arg Asn 
        195                 200                 205             


Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala 
    210                 215                 220                 


Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp 
225                 230                 235                 240 


Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu Pro Ile 
                245                 250                 255     


Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala Glu Tyr 
            260                 265                 270         


Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His Ala Glu 
        275                 280                 285             


Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala 
    290                 295                 300                 


Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile 
305                 310                 315                 320 


Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp 
                325                 330                 335     


Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  20
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  20

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Ser Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys 
                325                 330                 335     


Thr Cys Gly Ser Gly Gly Gly Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  21
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  21

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  22
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  22

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Gly Gly 
305                 310                 315                 320 


Arg Trp Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys 
                325                 330                 335     


Thr Cys Gly Trp Glu Gly Gly Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  23
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  23

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Arg Trp 
305                 310                 315                 320 


Gly Ser Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys 
                325                 330                 335     


Thr Cys Gly Ser Gly Trp Glu Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  24
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  24

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Gly Gly 
305                 310                 315                 320 


Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys 
                325                 330                 335     


Gly Gly Gly Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro 
            340                 345                 350         


Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu 
        355                 360                 365             


Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn 
    370                 375                 380                 


Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys 
385                 390                 395                 400 


Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu 
                405                 410                 415     


Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu 
            420                 425                 430         


Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu 
        435                 440                 445             


Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His 
    450                 455                 460                 


Arg Gln Leu Glu His His His His His His 
465                 470                 


<210>  25
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  25

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Gly Cys 
305                 310                 315                 320 


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Asp 
                325                 330                 335     


Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro 
            340                 345                 350         


Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser 
        355                 360                 365             


Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu Asn Gly 
    370                 375                 380                 


Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr Arg Lys 
385                 390                 395                 400 


Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser Leu Ser 
                405                 410                 415     


Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg 
            420                 425                 430         


Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys Ala Thr 
        435                 440                 445             


Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln Leu Glu 
    450                 455                 460                 


His His His His His His 
465                 470 


<210>  26
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  26

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Lys 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  27
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  27

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Lys Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  28
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  28

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Lys Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  29
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  29

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Lys 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Lys Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  30
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  30

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Lys Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Lys Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  31
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  31

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Lys 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Lys Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  32
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  32

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Lys 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Lys Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Lys Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  33
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  33

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Cys 
        435                 440                 445             


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser 
    450                 455                 460                 


Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475 


<210>  34
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  34

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
    450                 455                 460                 


Cys Gly Ser Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475             


<210>  35
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  35

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp 
    450                 455                 460                 


Cys Thr Cys Gly Ser Gly Gly Gly Leu Glu His His His His His His 
465                 470                 475                 480 


<210>  36
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  36

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Cys Asp Cys Ala Trp 
            500                 505                 510         


His Leu Gly Glu Leu Val Trp Cys Thr Cys Gly Ser Gly Gly Gly Leu 
        515                 520                 525             


Asp His His His His His His 
    530                 535 


<210>  37
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  37

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Arg Trp 
305                 310                 315                 320 


Gly Ser Gly Ala Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys 
                325                 330                 335     


Thr Ala Gly Ser Gly Trp Glu Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  38
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  38

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Gly Gly 
305                 310                 315                 320 


Arg Trp Gly Ala Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys 
                325                 330                 335     


Thr Ala Gly Trp Glu Gly Gly Asp Leu Glu Val Leu Met Glu Trp Leu 
            340                 345                 350         


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
        355                 360                 365             


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
    370                 375                 380                 


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
385                 390                 395                 400 


Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His 
                405                 410                 415     


Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser 
            420                 425                 430         


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val 
        435                 440                 445             


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
    450                 455                 460                 


His Arg Ser His Arg Gln Leu Glu His His His His His His 
465                 470                 475             


<210>  39
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  39

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Gly Ala 
305                 310                 315                 320 


Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Ala Gly Asp 
                325                 330                 335     


Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro 
            340                 345                 350         


Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser 
        355                 360                 365             


Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu Asn Gly 
    370                 375                 380                 


Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr Arg Lys 
385                 390                 395                 400 


Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser Leu Ser 
                405                 410                 415     


Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg 
            420                 425                 430         


Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys Ala Thr 
        435                 440                 445             


Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln Leu Glu 
    450                 455                 460                 


His His His His His His 
465                 470 


<210>  40
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNA sequence

<400>  40

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Tyr Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys 
            420                 425                 430         


Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg Gln 
        435                 440                 445             


Leu Glu His His His His His His 
    450                 455     


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  41

Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  42

Gly Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  43

Leu Thr Glu Val Glu Thr Tyr Val Leu Ser 
1               5                   10  


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  44

Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
1               5                   10              


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  45

Cys Ala Thr Cys Glu Gln Ile Ala Asp 
1               5                   


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  46

Ala Gln Glu Ala Gln Lys Gln Lys 
1               5               


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  47

Tyr Gly Thr Ala Arg 
1               5   


<210>  48
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  48

Thr Asp Asp 
1           


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<400>  49

Leu Xaa Glu Asn Leu Gly Thr Arg 
1               5               


<210>  50
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  50

Ile Asp Val 
1           


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any amino acid

<400>  51

Thr Gly Xaa Arg Thr 
1               5   


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence fragments of SAPNX scaffolding protein

<400>  52

Glu His His His His His His 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  53

Leu Val Pro Arg Gly Ser Gly 
1               5           


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  54

Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
1               5                   10      


<210>  55
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX scaffolding protein

<400>  55

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val 
            420                 425                 430     


<210>  56
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional additional segment of SAPNX scaffolding protein

<400>  56

Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg Ser His Arg 
1               5                   10                  15      


Gln Leu Glu His His His His His His 
            20                  25  


<210>  57
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  57

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Leu Val 
    290                 295                 300                 


Pro Arg Gly Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu 
305                 310                 315                 320 


Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp 
                325                 330                 335     


Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly 
            340                 345                 350         


Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg 
        355                 360                 365             


Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met 
    370                 375                 380                 


Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe 
385                 390                 395                 400 


His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala 
                405                 410                 415     


Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu 
            420                 425                 430         


Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser 
        435                 440                 445             


Gln His Arg Ser His Arg Gln His His His His His His 
    450                 455                 460     


<210>  58
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  58

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Leu Val Pro Arg Gly 
    130                 135                 140                 


Ser Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala Ala Val 
145                 150                 155                 160 


Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp Phe Tyr 
                165                 170                 175     


Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala Val Arg 
            180                 185                 190         


Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala Ala Ala 
        195                 200                 205             


Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro Arg Ile 
    210                 215                 220                 


Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr Leu Pro 
225                 230                 235                 240 


Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser Ala Glu 
                245                 250                 255     


Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His Ala 
            260                 265                 270         


Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu 
        275                 280                 285             


Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser 
    290                 295                 300                 


Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu 
305                 310                 315                 320 


Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp 
                325                 330                 335     


Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly 
            340                 345                 350         


Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg 
        355                 360                 365             


Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met 
    370                 375                 380                 


Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe 
385                 390                 395                 400 


His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala 
                405                 410                 415     


Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu 
            420                 425                 430         


Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser 
        435                 440                 445             


Gln His Arg Ser His Arg Gln His His His His His His 
    450                 455                 460     


<210>  59
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  59

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Leu 
                245                 250                 255     


Val Pro Arg Gly Ser Gly Ala Pro His Gly Leu Leu Trp Thr His Ala 
            260                 265                 270         


Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln Glu 
        275                 280                 285             


Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser 
    290                 295                 300                 


Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu 
305                 310                 315                 320 


Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp 
                325                 330                 335     


Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly 
            340                 345                 350         


Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg 
        355                 360                 365             


Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met 
    370                 375                 380                 


Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe 
385                 390                 395                 400 


His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala 
                405                 410                 415     


Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu 
            420                 425                 430         


Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser 
        435                 440                 445             


Gln His Arg Ser His Arg Gln His His His His His His 
    450                 455                 460     


<210>  60
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  60

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Gly Leu Val Pro Arg Gly Ser Gly Ser Ala 
                245                 250                 255     


Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr His 
            260                 265                 270         


Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala Gln 
        275                 280                 285             


Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
    290                 295                 300                 


Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu 
305                 310                 315                 320 


Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu 
                325                 330                 335     


Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu 
            340                 345                 350         


Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg 
        355                 360                 365             


Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn 
    370                 375                 380                 


Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr 
385                 390                 395                 400 


Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu 
                405                 410                 415     


Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr 
            420                 425                 430         


Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp 
        435                 440                 445             


Ser Gln His Arg Ser His Arg Gln His His His His His His 
    450                 455                 460         


<210>  61
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  61

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Gly 
            340                 345                 350         


Leu Val Pro Arg Gly Ser Gly Glu Arg Gly Leu Gln Arg Arg Arg Phe 
        355                 360                 365             


Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys 
    370                 375                 380                 


Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly 
385                 390                 395                 400 


Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys 
                405                 410                 415     


Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala 
            420                 425                 430         


Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His 
        435                 440                 445             


Arg Ser His Arg Gln His His His His His His 
    450                 455                 


<210>  62
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  62

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Ala Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Gly Ser 
    290                 295                 300                 


Glu Asn Leu Tyr Phe Gln Gly Gly Ser Pro Leu Lys Ala Glu Ile Ala 
305                 310                 315                 320 


Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val 
                325                 330                 335     


Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys 
            340                 345                 350         


Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly 
        355                 360                 365             


Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp 
    370                 375                 380                 


Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg 
385                 390                 395                 400 


Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala 
                405                 410                 415     


Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala 
            420                 425                 430         


Val Thr Thr Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln 
        435                 440                 445             


Ile Ala Asp Ser Gln His Arg Ser His Arg Gln Leu Glu His His His 
    450                 455                 460                 


His His His 
465         


<210>  63
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide

<400>  63

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly 
            20                  25                  30          


Ser Thr Pro Val Val Leu Ile His Gly Phe Pro Leu Ser Gly His Ser 
        35                  40                  45              


Trp Glu Arg Gln Ser Ala Ala Leu Leu Asp Ala Gly Ala Arg Val Ile 
    50                  55                  60                  


Thr Tyr Asp Arg Arg Gly Phe Gly Gln Ser Ser Gln Pro Thr Thr Gly 
65                  70                  75                  80  


Tyr Asp Tyr Asp Thr Phe Ala Ala Asp Leu Asn Thr Val Leu Glu Thr 
                85                  90                  95      


Leu Asp Leu Gln Asp Ala Val Leu Val Gly Phe Ser Met Gly Thr Gly 
            100                 105                 110         


Glu Val Ala Arg Tyr Val Ser Ser Tyr Gly Thr Ala Arg Ile Ala Ala 
        115                 120                 125             


Val Ala Phe Leu Ala Ser Leu Glu Pro Phe Leu Leu Lys Thr Asp Asp 
    130                 135                 140                 


Asn Pro Asp Gly Ala Ala Pro Gln Glu Phe Phe Asp Gly Ile Val Ala 
145                 150                 155                 160 


Ala Val Lys Ala Asp Arg Tyr Ala Phe Tyr Thr Gly Phe Phe Asn Asp 
                165                 170                 175     


Phe Tyr Asn Leu Asp Glu Asn Leu Gly Thr Arg Ile Ser Glu Glu Ala 
            180                 185                 190         


Val Arg Asn Ser Trp Asn Thr Ala Ala Ser Gly Gly Phe Phe Ala Ala 
        195                 200                 205             


Ala Ala Ala Pro Thr Thr Trp Tyr Thr Asp Phe Arg Ala Asp Ile Pro 
    210                 215                 220                 


Arg Ile Asp Val Pro Ala Leu Ile Leu His Gly Thr Gly Asp Arg Thr 
225                 230                 235                 240 


Leu Pro Ile Glu Asn Thr Ala Arg Val Phe His Lys Ala Leu Pro Ser 
                245                 250                 255     


Ala Glu Tyr Val Glu Val Glu Gly Ala Pro His Gly Leu Leu Trp Thr 
            260                 265                 270         


His Ala Glu Glu Val Asn Thr Ala Leu Leu Ala Phe Leu Ala Lys Ala 
        275                 280                 285             


Gln Glu Ala Gln Lys Gln Lys Leu Leu Thr Glu Val Glu Thr Tyr Val 
    290                 295                 300                 


Leu Ser Ile Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg 
305                 310                 315                 320 


Leu Glu Asp Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met 
                325                 330                 335     


Glu Trp Leu Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile 
            340                 345                 350         


Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln 
        355                 360                 365             


Arg Arg Arg Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn 
    370                 375                 380                 


Asn Met Asp Lys Ala Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile 
385                 390                 395                 400 


Thr Phe His Gly Ala Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala 
                405                 410                 415     


Leu Ala Ser Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr 
            420                 425                 430         


Thr Glu Val Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala 
        435                 440                 445             


Asp Ser Gln His Arg Ser His Arg Gln Leu Glu His His His His His 
    450                 455                 460                 


His 
465 


<210>  64
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAPNX sequence comprising exemplary passenger peptide


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any amino acid

<400>  64

Met Pro Phe Ile Thr Val Gly Gln Glu Asn Ser Thr Ser Ile Asp Leu 
1               5                   10                  15      


Tyr Tyr Glu Asp His Gly Thr Gly Thr Pro Val Val Leu Ile His Gly 
            20                  25                  30          


Phe Pro Leu Ser Gly His Ser Trp Glu Arg Gln Ser Ala Ala Leu Leu 
        35                  40                  45              


Asp Ala Gly Xaa Arg Val Ile Thr Tyr Asp Arg Arg Gly Phe Gly Gln 
    50                  55                  60                  


Ser Ser Gln Pro Thr Thr Gly Tyr Asp Tyr Asp Thr Phe Ala Ala Asp 
65                  70                  75                  80  


Leu Asn Thr Val Leu Glu Thr Leu Asp Leu Gln Asp Ala Val Leu Val 
                85                  90                  95      


Gly Phe Ser Met Gly Thr Gly Glu Val Ala Arg Tyr Val Ser Ser Tyr 
            100                 105                 110         


Gly Thr Ala Arg Ile Ala Ala Val Ala Phe Leu Ala Ser Leu Glu Pro 
        115                 120                 125             


Phe Leu Leu Lys Thr Asp Asp Asn Pro Asp Gly Ala Ala Pro Gln Glu 
    130                 135                 140                 


Phe Phe Asp Gly Ile Val Ala Ala Val Lys Ala Asp Arg Tyr Ala Phe 
145                 150                 155                 160 


Tyr Thr Gly Phe Phe Asn Asp Phe Tyr Asn Leu Asp Glu Asn Leu Gly 
                165                 170                 175     


Thr Arg Ile Ser Glu Glu Ala Val Arg Asn Ser Trp Asn Thr Ala Ala 
            180                 185                 190         


Ser Gly Gly Phe Phe Ala Ala Ala Ala Ala Pro Thr Thr Trp Tyr Thr 
        195                 200                 205             


Asp Phe Arg Ala Asp Ile Pro Arg Ile Asp Val Pro Ala Leu Ile Leu 
    210                 215                 220                 


His Gly Thr Gly Asp Arg Thr Leu Pro Ile Glu Asn Thr Ala Arg Val 
225                 230                 235                 240 


Phe His Lys Ala Leu Pro Ser Ala Glu Tyr Val Glu Val Glu Gly Ala 
                245                 250                 255     


Pro His Gly Leu Leu Trp Thr His Ala Glu Glu Val Asn Thr Ala Leu 
            260                 265                 270         


Leu Ala Phe Leu Ala Lys Ala Gln Glu Ala Gln Lys Gln Lys Leu Leu 
        275                 280                 285             


Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro Ser Gly Pro Leu 
    290                 295                 300                 


Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe Ala Gly Lys Asn 
305                 310                 315                 320 


Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr Arg Pro Ile Leu 
                325                 330                 335     


Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
            340                 345                 350         


Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val Gln Asn Ala Leu 
        355                 360                 365             


Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala Val Lys Leu Tyr 
    370                 375                 380                 


Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala Lys Glu Ile Ser 
385                 390                 395                 400 


Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met Gly Leu Ile Tyr 
                405                 410                 415     


Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe Gly Leu Val 
            420                 425                 430     


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any amino acid

<400>  65

Leu Pro Xaa Thr Gly 
1               5   


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  66

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  67

Ala Thr His Ile Lys Phe Ser Lys Arg Asp 
1               5                   10  


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  68

Cys Cys Pro Gly Cys Cys 
1               5       


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  69

Asp Ile Pro Ala Thr Tyr Glu Phe Thr Asp Gly Lys His Tyr Ile Thr 
1               5                   10                  15      


Asn Glu Pro Ile Pro Pro Lys 
            20              


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  70

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  71

Asp Pro Ile Val Met Ile Asp Asn Asp Lys Pro Ile Thr 
1               5                   10              


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  72

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  73

Glu Glu Glu Glu Glu Glu 
1               5       


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  74

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  75

Glu Val His Thr Asn Gln Asp Pro Leu Asp 
1               5                   10  


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  76

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  77
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  77

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  78

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  79

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  80

Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  81

Lys Leu Gly Ser Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  82
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  82

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  83

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      


<210>  84
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  84

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210>  85
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  85

Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  86

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  87
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  87

Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu 
1               5                   10              


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  88

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  89
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  89

Thr Glu Thr Ser Gln Val Ala Pro Ala 
1               5                   


<210>  90
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  90

Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Glu Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  91

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  92

Val Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
1               5                   10                  


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  93

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  94

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Passenger peptide

<400>  95

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


