                         SEQUENCE LISTING

<110>  BIOVERATIV THERAPEUTICS INC.
 
<120>  MODIFIED BACULOVIRUS SYSTEM FOR IMPROVED PRODUCTION OF 
       CLOSED-ENDED DNA (ceDNA)

<130>  SA9-475PC

<150>  US 63/069,115
<151>  2020-08-23

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  1
ctctgggcca gcttgcttgg ggttgccttg acactaagac aagcggcgcg ccgcttgatc       60

ttagtggcac gtcaacccca agcgctggcc cagagccaac cctaattccg gaagtcccgc      120

ccaccggaag tgacgtcaca ggaaatgacg tcacaggaaa tgacgtaatt gtccgccatc      180

ttgtaccgga agtcccgcct accggcggcg accggcggca tctgatttgg tgtcttcttt      240

taaatttt                                                               248


<210>  2
<211>  383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  2
ccaaatcaga tgccgccggt cgccgccggt aggcgggact tccggtacaa gatggcggac       60

aattacgtca tttcctgtga cgtcatttcc tgtgacgtca cttccggtgg gcgggacttc      120

cggaattagg gttggctctg ggccagcttg cttggggttg ccttgacact aagacaagcg      180

gcgcgccgct tgatcttagt ggcacgtcaa ccccaagcgc tggcccagag ccaaccctaa      240

ttccggaagt cccgcccacc ggaagtgacg tcacaggaaa tgacgtcaca ggaaatgacg      300

taattgtccg ccatcttgta ccggaagtcc cgcctaccgg cggcgaccgg cggcatctga      360

tttggtgtct tcttttaaat ttt                                              383


<210>  3
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  3
cggtgacgtg tttccggctg ttaggttgac cacgcgcatg ccgcgcggtc agcccaatag       60

ttaagccgga aacacgtcac cggaagtcac atgaccggaa gtcacgtgac cggaaacacg      120

tgacaggaag cacgtgaccg gaactacgtc accggatgtg cgtcaccgga agcatgtgac      180

cggaacttgc gtcacttccc cctcccctga ttggctggtt cgaacgaacg aaccctccaa      240

tgagactcaa ggacaagagg atattttgcg cgccaggaag tg                         282


<210>  4
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  4
ctcattggag ggttcgttcg ttcgaaccag ccaatcaggg gagggggaag tgacgcaagt       60

tccggtcaca tgcttccggt gacgcacatc cggtgacgta gttccggtca cgtgcttcct      120

gtcacgtgtt tccggtcacg tgacttccgg tcatgtgact tccggtgacg tgtttccggc      180

tgttaggttg accacgcgca tgccgcgcgg tcagcccaat agttaagccg gaaacacgtc      240

accggaagtc acatgaccgg aagtcacgtg accggaaaca cgtgacagga agcacgtgac      300

cggaactacg tcaccggatg tgcgtcaccg gaagcatgtg accggaactt gcgtcacttc      360

cccctcccct gattggctgg ttcgaacgaa cgaaccctcc aatgagactc aaggacaaga      420

ggatattttg cgcgccagga agtg                                             444


<210>  5
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  5
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  6
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  6
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  7
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  7
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  8
<211>  119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  8
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcag       119


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  9
cacgttgacc agcatggtgt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.

<400>  10
gacgtgtcca agaaattgat                                                   20


<210>  11
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide sequence.


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n can be any nucleotide.

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n can be any nucleotide.

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n can be any nucleotide.

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n can be any nucleotide.

<400>  11
gatcnnnnga tc                                                           12


<210>  12
<211>  153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBoV1 WT ITR 5'

<400>  12
ttgttgttgt acatgcgcca tcttagtttt atatcagctg gcgccttagt tatataacat       60

gcatgttata taactaaggc gccagctgat ataaaactaa gatggcgcat gtacaacaac      120

aacacattaa aagatataga gtttcgcgat tgc                                   153


<210>  13
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HBoV1 WT ITR 3'

<400>  13
tatatgtgac gtggttgtac agacgccatc ttggaatcca atatgtctgc cggcgattag       60

atcatgcgcg cgcgcagcgc gctgcgcgca gcgcaggcat gactgagccg gcagacatat      120

tggattccaa gatggcgtct gtacaaccac                                       150


<210>  14
<211>  7891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V2.0 Human codon optimized mTTR-Intron-BDD-FVIIIXTEN-WPRE-bGHPoly
       expression cassette

<400>  14
ggccccaggt taatttttaa aaagcagtca aaggtcaaag tggcccttgg cagcatttac       60

tctctctatt gactttggtt aataatctca ggagcacaaa cattcctgga ggcaggagaa      120

gaaatcaaca tcctggactt atcctctggg cctctcccca ccttcgatgg ccccaggtta      180

atttttaaaa agcagtcaaa ggtcaaagtg gcccttggca gcatttactc tctctattga      240

ctttggttaa taatctcagg agcacaaaca ttcctggagg caggagaaga aatcaacatc      300

ctggacttat cctctgggcc tctccccacc gatatctacc tgctgatcgc ccggcccctg      360

ttcaaacatg tcctaatact ctgtcggggc aaaggtcggc agtagttttc catcttactc      420

aacatcctcc cagtgtacgt aggatcctgt ctgtctgcac atttcgtaga gcgagtgttc      480

cgatactcta atctcccggg gcaaaggtcg tattgactta ggttacttat tctccttttg      540

ttgactaagt caataatcag aatcagcagg tttggagtca gcttggcagg gatcagcagc      600

ctgggttgga aggagggggt ataaaagccc cttcaccagg agaagccgtc acacagatcc      660

acaagctcct gctaggaatt ctcaggagca caaacattcc tggaggcagg agaagaaatc      720

aacatcctgg acttatcctc tgggcctctc cccaccgata tctacctgct gatcgcccgg      780

cccctgttca aacatgtcct aatactctgt cggggcaaag gtcggcagta gttttccatc      840

ttactcaaca tcctcccagt gtacgtagga tcctgtctgt ctgcacattt cgtagagcga      900

gtgttccgat actctaatct cccggggcaa aggtcgtatt gacttaggtt acttattctc      960

cttttgttga ctaagtcaat aatcagaatc agcaggtttg gagtcagctt ggcagggatc     1020

agcagcctgg gttggaagga gggggtataa aagccccttc accaggagaa gccgtcacac     1080

agatccacaa gctcctgcta gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc     1140

cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac aggtgagcgg     1200

gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg gtttattgac ggcttgtttc     1260

ttttctgtgg ctgcgtgaaa gccttgaggg gctccgggaa ggccctttgt gcggggggag     1320

cggctcgggg ggtgcgtgcg tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct     1380

gcccggcggc tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg     1440

cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa     1500

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg     1560

gctgcaaccc cccctgcacc cccctccccg agttgctgag cacggcccgg cttcgggtgc     1620

ggggctccgt acggggcgtg gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt     1680

gggggtgccg ggcggggcgg ggccgcctcg ggccggggag ggctcggggg aggggcgcgg     1740

cggcccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1800

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctgtgcgg agccgaaatc     1860

tgggaggcgc cgccgcaccc cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag     1920

gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct     1980

ccagcctcgg ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg     2040

gttcggcttc tggcgtgtga ccggcggctc tagagcctct gctaaccttg ttcttgcctt     2100

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     2160

caaagaatta ctcgaggcca ccatgcagat tgaactgtcc acttgcttct tcctgtgcct     2220

cctgcggttt tgcttctcgg ccacccgccg gtattactta ggtgctgtgg aactgagctg     2280

ggactacatg cagtccgacc tgggagaact gccggtggac gcgagattcc cacctagagt     2340

cccgaagtcc ttcccattca acacctccgt ggtctacaaa aagaccctgt tcgtggagtt     2400

cactgaccac cttttcaata ttgccaagcc gcgccccccc tggatgggcc tgcttggtcc     2460

tacgatccaa gcagaggtct acgacaccgt ggtcatcaca ctgaagaaca tggcctcaca     2520

ccccgtgtcg ctgcatgctg tgggagtgtc ctactggaag gcctcagagg gtgccgaata     2580

tgatgaccag accagccaga gggaaaagga ggatgacaaa gtgttcccgg gtggcagcca     2640

cacttacgtg tggcaagtgc tgaaggaaaa cgggcctatg gcgtcggacc ccctatgcct     2700

gacctactcc tacctgtccc atgtggacct tgtgaaggat ctcaactcgg gactgatcgg     2760

cgccctcttg gtgtgcagag aaggcagcct ggcgaaggaa aagactcaga ccctgcacaa     2820

gttcattctg ttgtttgctg tgttcgatga aggaaagtcc tggcactcag aaaccaagaa     2880

ctcgctgatg caggatagag atgcggcctc ggccagagcc tggcctaaaa tgcacaccgt     2940

caacggatat gtgaacaggt cgctccctgg cctcatcggc tgccacagaa agtccgtgta     3000

ttggcatgtg atcggcatgg gtactactcc ggaagtgcat agtatctttc tggagggcca     3060

taccttcttg gtgcgcaacc acagacaggc ctcgctggaa atctcgccta tcactttctt     3120

gactgcgcag accctcctta tggaccttgg acagttcctg ctgttctgtc acatcagctc     3180

ccatcagcat gatgggatgg aggcctatgt caaagtggac tcctgccctg aggagccaca     3240

gctccggatg aagaacaatg aggaagcgga ggattacgac gacgacctga ctgacagcga     3300

aatggacgtc gtgcgattcg atgacgacaa cagcccgtcc ttcatccaaa ttagatcagt     3360

ggcgaagaag caccccaaga cctgggtgca ctacattgcc gccgaggaag aggactggga     3420

ctacgcgccg ctggtgctgg cgccagacga caggagctac aagtcccagt acctcaacaa     3480

cgggccgcag cgcattggca ggaagtacaa gaaagtccgc ttcatggcct acactgatga     3540

aaccttcaag acgagggaag ccatccagca cgagtcaggc atcctgggac cgctccttta     3600

cggcgaagtc ggggataccc tgctcatcat tttcaagaac caggcatcgc ggccctacaa     3660

catctaccct cacgggatca cagacgtgcg cccgctctac tcccgccggc tgcccaaggg     3720

agtgaagcac ctgaaggatt ttcccatcct gccgggagaa atcttcaagt acaagtggac     3780

cgtgactgtg gaagatggcc ctaccaagtc ggaccctcgc tgtctgaccc ggtactattc     3840

ctcgtttgtg aacatggagc gcgacctggc ctcggggctg attggtccgc tgctgatctg     3900

ctacaaggag tccgtggacc agcgcgggaa ccagatcatg tccgacaagc gcaacgtgat     3960

cctgttctct gtctttgatg aaaacagatc gtggtacttg actgagaata tccagcggtt     4020

cctgcccaac ccagcgggag tgcaactgga ggacccggag ttccaggcct caaacattat     4080

gcactctatc aacggctatg tgttcgactc gctccaactg agcgtgtgcc tgcatgaagt     4140

ggcatactgg tacattctgt ccatcggagc ccagaccgac ttcctgtccg tgttcttctc     4200

cggatacacc ttcaagcata agatggtgta cgaggacact ctgaccctct tcccattttc     4260

cggagaaact gtgttcatgt caatggaaaa cccgggcttg tggattctgg gttgccataa     4320

ctcggacttc cggaatagag ggatgaccgc cctgctgaaa gtgtccagct gtgacaagaa     4380

taccggcgat tactacgagg acagctatga ggacatctcc gcttatctgc tgtccaagaa     4440

caacgccatt gaacccaggt ccttctccca aaacggtgca ccgacctccg aaagcgccac     4500

cccagagtca ggacctggct cggaaccggc tacctcgggc tcagagacac cggggacttc     4560

cgagtccgca acccccgaga gtggacccgg atccgaacca gcaacctcag gatcagaaac     4620

cccgggaact tcggaatccg ccactcccga gtcgggacca ggcacctcca ctgagccttc     4680

cgagggaagc gcccccggat cccctgctgg atcccctacc agcactgaag aaggcacctc     4740

agaatccgcg acccctgagt ccggccctgg aagcgaaccc gccacctccg gttccgaaac     4800

ccctgggact agcgagagcg ccactccgga atcgggccca ggaagccctg ccggatcccc     4860

gaccagcacc gaggagggaa gccccgccgg gtcaccgact tccactgagg agggagcctc     4920

atcccccccc gtgctgaagc ggcatcaaag agagatcacc aggaccactc tccagtccga     4980

tcaggaagaa attgactacg acgatactat cagcgtggag atgaagaagg aggacttcga     5040

catctacgat gaggatgaga accagtcccc tcggagcttt cagaagaaaa cccgccacta     5100

cttcatcgct gccgtggagc ggctgtggga ttacgggatg tccagctcac cgcatgtgct     5160

gcggaataga gcgcagtcag gatcggtgcc ccagttcaag aaggtcgtgt tccaagagtt     5220

caccgacggg tccttcactc aacccctgta ccggggcgaa ctcaacgaac acctgggact     5280

gcttgggccg tatatcaggg cagaagtgga agataacatc atggtcacct tccgcaacca     5340

ggcctcccgg ccgtacagct tctactcttc actgatctcc tacgaggaag atcagcggca     5400

gggagccgag ccccggaaga acttcgtcaa gcctaacgaa actaagacct acttttggaa     5460

ggtccagcat cacatggccc cgaccaaaga cgagttcgac tgtaaagcct gggcctactt     5520

ctccgatgtg gacctggaga aggacgtgca ctcgggactc attggcccgc tccttgtgtg     5580

ccatactaat accctgaacc ctgctcacgg tcgccaagtc acagtgcagg agttcgccct     5640

cttcttcacc atcttcgatg aaacaaagtc ctggtacttt actgagaaca tggaacgcaa     5700

ttgcagggca ccctgcaaca tccagatgga agatcccacc ttcaaggaaa actaccggtt     5760

tcatgccatt aacggctaca taatggacac gttgccagga ctggtcatgg cccaggacca     5820

gagaatccgg tggtatctgc tctccatggg ctccaacgaa aacattcaca gcattcattt     5880

ttccggccat gtgttcaccg tccggaagaa ggaagagtac aagatggctc tgtacaacct     5940

ctaccctgga gtgttcgaga ctgtggaaat gctgcctagc aaggccggca tttggagagt     6000

ggaatgcctg atcggagagc atttgcacgc cggaatgtcc accctgtttc ttgtgtactc     6060

caacaagtgc cagaccccgc tgggaatggc ctcaggtcat attagggatt tccagatcac     6120

tgcttcgggg cagtacgggc agtgggcacc taagttggcc cggctgcact actctggctc     6180

catcaatgcc tggtccacca aggaaccctt ctcctggatt aaggtggacc tcctggcccc     6240

aatgattatt cacggtatta agacccaggg tgcccgacag aagttctcct cactctacat     6300

ctcgcaattc atcataatgt acagcctgga tgggaagaag tggcagacct accggggaaa     6360

ctccactgga acgctcatgg tgtttttcgg caacgtggac tcctccggca ttaagcacaa     6420

catcttcaac cctccgatca ttgctcggta catccggctg cacccaactc actacagcat     6480

ccggtccacc ctgcggatgg aactgatggg ttgtgacctg aactcctgct ccatgcccct     6540

tgggatggaa tccaaggcca ttagcgatgc acagatcacc gcctcttcat acttcaccaa     6600

catgttcgcg acctggtccc cgtcgaaggc ccgcctgcac ctccaaggtc gctccaatgc     6660

gtggcggcct caagtgaaca accccaagga gtggctccag gtcgacttcc aaaagaccat     6720

gaaggtcacc ggagtgacca cccagggcgt gaagtccctg ctgacctcta tgtacgttaa     6780

ggagttcctc atctcctcaa gccaagacgg acatcagtgg accctgttct tccaaaacgg     6840

aaaagtcaaa gtattccagg gcaaccagga ctccttcacc cctgtggtca acagcctgga     6900

ccccccattg ctgacccgct acctccgcat ccacccccaa agctgggtcc accagatcgc     6960

actgcgcatg gaggtccttg gatgcgaagc ccaagatctg tactaagcgg ccgctcataa     7020

tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc     7080

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat     7140

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg     7200

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg     7260

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat     7320

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt     7380

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc     7440

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa     7500

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg     7560

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgctgc ctaggcgact     7620

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     7680

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     7740

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     7800

gaagacaata gcaggcatgc tggggaagac catgggcgcg ccaggcctgt cgacgcccgg     7860

gcggtaccgc gatcgctcgc gacgcataaa g                                    7891


<210>  15
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding B-domain deleted (BDD) 
       codon-optimized human Factor VIII (BDDcoFVIII) fused with 144 
       amino acid XTEN

<400>  15
atgcagattg aactgtccac ttgcttcttc ctgtgcctcc tgcggttttg cttctcggcc       60

acccgccggt attacttagg tgctgtggaa ctgagctggg actacatgca gtccgacctg      120

ggagaactgc cggtggacgc gagattccca cctagagtcc cgaagtcctt cccattcaac      180

acctccgtgg tctacaaaaa gaccctgttc gtggagttca ctgaccacct tttcaatatt      240

gccaagccgc gccccccctg gatgggcctg cttggtccta cgatccaagc agaggtctac      300

gacaccgtgg tcatcacact gaagaacatg gcctcacacc ccgtgtcgct gcatgctgtg      360

ggagtgtcct actggaaggc ctcagagggt gccgaatatg atgaccagac cagccagagg      420

gaaaaggagg atgacaaagt gttcccgggt ggcagccaca cttacgtgtg gcaagtgctg      480

aaggaaaacg ggcctatggc gtcggacccc ctatgcctga cctactccta cctgtcccat      540

gtggaccttg tgaaggatct caactcggga ctgatcggcg ccctcttggt gtgcagagaa      600

ggcagcctgg cgaaggaaaa gactcagacc ctgcacaagt tcattctgtt gtttgctgtg      660

ttcgatgaag gaaagtcctg gcactcagaa accaagaact cgctgatgca ggatagagat      720

gcggcctcgg ccagagcctg gcctaaaatg cacaccgtca acggatatgt gaacaggtcg      780

ctccctggcc tcatcggctg ccacagaaag tccgtgtatt ggcatgtgat cggcatgggt      840

actactccgg aagtgcatag tatctttctg gagggccata ccttcttggt gcgcaaccac      900

agacaggcct cgctggaaat ctcgcctatc actttcttga ctgcgcagac cctccttatg      960

gaccttggac agttcctgct gttctgtcac atcagctccc atcagcatga tgggatggag     1020

gcctatgtca aagtggactc ctgccctgag gagccacagc tccggatgaa gaacaatgag     1080

gaagcggagg attacgacga cgacctgact gacagcgaaa tggacgtcgt gcgattcgat     1140

gacgacaaca gcccgtcctt catccaaatt agatcagtgg cgaagaagca ccccaagacc     1200

tgggtgcact acattgccgc cgaggaagag gactgggact acgcgccgct ggtgctggcg     1260

ccagacgaca ggagctacaa gtcccagtac ctcaacaacg ggccgcagcg cattggcagg     1320

aagtacaaga aagtccgctt catggcctac actgatgaaa ccttcaagac gagggaagcc     1380

atccagcacg agtcaggcat cctgggaccg ctcctttacg gcgaagtcgg ggataccctg     1440

ctcatcattt tcaagaacca ggcatcgcgg ccctacaaca tctaccctca cgggatcaca     1500

gacgtgcgcc cgctctactc ccgccggctg cccaagggag tgaagcacct gaaggatttt     1560

cccatcctgc cgggagaaat cttcaagtac aagtggaccg tgactgtgga agatggccct     1620

accaagtcgg accctcgctg tctgacccgg tactattcct cgtttgtgaa catggagcgc     1680

gacctggcct cggggctgat tggtccgctg ctgatctgct acaaggagtc cgtggaccag     1740

cgcgggaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctctgt ctttgatgaa     1800

aacagatcgt ggtacttgac tgagaatatc cagcggttcc tgcccaaccc agcgggagtg     1860

caactggagg acccggagtt ccaggcctca aacattatgc actctatcaa cggctatgtg     1920

ttcgactcgc tccaactgag cgtgtgcctg catgaagtgg catactggta cattctgtcc     1980

atcggagccc agaccgactt cctgtccgtg ttcttctccg gatacacctt caagcataag     2040

atggtgtacg aggacactct gaccctcttc ccattttccg gagaaactgt gttcatgtca     2100

atggaaaacc cgggcttgtg gattctgggt tgccataact cggacttccg gaatagaggg     2160

atgaccgccc tgctgaaagt gtccagctgt gacaagaata ccggcgatta ctacgaggac     2220

agctatgagg acatctccgc ttatctgctg tccaagaaca acgccattga acccaggtcc     2280

ttctcccaaa acggtgcacc gacctccgaa agcgccaccc cagagtcagg acctggctcg     2340

gaaccggcta cctcgggctc agagacaccg gggacttccg agtccgcaac ccccgagagt     2400

ggacccggat ccgaaccagc aacctcagga tcagaaaccc cgggaacttc ggaatccgcc     2460

actcccgagt cgggaccagg cacctccact gagccttccg agggaagcgc ccccggatcc     2520

cctgctggat cccctaccag cactgaagaa ggcacctcag aatccgcgac ccctgagtcc     2580

ggccctggaa gcgaacccgc cacctccggt tccgaaaccc ctgggactag cgagagcgcc     2640

actccggaat cgggcccagg aagccctgcc ggatccccga ccagcaccga ggagggaagc     2700

cccgccgggt caccgacttc cactgaggag ggagcctcat ccccccccgt gctgaagcgg     2760

catcaaagag agatcaccag gaccactctc cagtccgatc aggaagaaat tgactacgac     2820

gatactatca gcgtggagat gaagaaggag gacttcgaca tctacgatga ggatgagaac     2880

cagtcccctc ggagctttca gaagaaaacc cgccactact tcatcgctgc cgtggagcgg     2940

ctgtgggatt acgggatgtc cagctcaccg catgtgctgc ggaatagagc gcagtcagga     3000

tcggtgcccc agttcaagaa ggtcgtgttc caagagttca ccgacgggtc cttcactcaa     3060

cccctgtacc ggggcgaact caacgaacac ctgggactgc ttgggccgta tatcagggca     3120

gaagtggaag ataacatcat ggtcaccttc cgcaaccagg cctcccggcc gtacagcttc     3180

tactcttcac tgatctccta cgaggaagat cagcggcagg gagccgagcc ccggaagaac     3240

ttcgtcaagc ctaacgaaac taagacctac ttttggaagg tccagcatca catggccccg     3300

accaaagacg agttcgactg taaagcctgg gcctacttct ccgatgtgga cctggagaag     3360

gacgtgcact cgggactcat tggcccgctc cttgtgtgcc atactaatac cctgaaccct     3420

gctcacggtc gccaagtcac agtgcaggag ttcgccctct tcttcaccat cttcgatgaa     3480

acaaagtcct ggtactttac tgagaacatg gaacgcaatt gcagggcacc ctgcaacatc     3540

cagatggaag atcccacctt caaggaaaac taccggtttc atgccattaa cggctacata     3600

atggacacgt tgccaggact ggtcatggcc caggaccaga gaatccggtg gtatctgctc     3660

tccatgggct ccaacgaaaa cattcacagc attcattttt ccggccatgt gttcaccgtc     3720

cggaagaagg aagagtacaa gatggctctg tacaacctct accctggagt gttcgagact     3780

gtggaaatgc tgcctagcaa ggccggcatt tggagagtgg aatgcctgat cggagagcat     3840

ttgcacgccg gaatgtccac cctgtttctt gtgtactcca acaagtgcca gaccccgctg     3900

ggaatggcct caggtcatat tagggatttc cagatcactg cttcggggca gtacgggcag     3960

tgggcaccta agttggcccg gctgcactac tctggctcca tcaatgcctg gtccaccaag     4020

gaacccttct cctggattaa ggtggacctc ctggccccaa tgattattca cggtattaag     4080

acccagggtg cccgacagaa gttctcctca ctctacatct cgcaattcat cataatgtac     4140

agcctggatg ggaagaagtg gcagacctac cggggaaact ccactggaac gctcatggtg     4200

tttttcggca acgtggactc ctccggcatt aagcacaaca tcttcaaccc tccgatcatt     4260

gctcggtaca tccggctgca cccaactcac tacagcatcc ggtccaccct gcggatggaa     4320

ctgatgggtt gtgacctgaa ctcctgctcc atgccccttg ggatggaatc caaggccatt     4380

agcgatgcac agatcaccgc ctcttcatac ttcaccaaca tgttcgcgac ctggtccccg     4440

tcgaaggccc gcctgcacct ccaaggtcgc tccaatgcgt ggcggcctca agtgaacaac     4500

cccaaggagt ggctccaggt cgacttccaa aagaccatga aggtcaccgg agtgaccacc     4560

cagggcgtga agtccctgct gacctctatg tacgttaagg agttcctcat ctcctcaagc     4620

caagacggac atcagtggac cctgttcttc caaaacggaa aagtcaaagt attccagggc     4680

aaccaggact ccttcacccc tgtggtcaac agcctggacc ccccattgct gacccgctac     4740

ctccgcatcc acccccaaag ctgggtccac cagatcgcac tgcgcatgga ggtccttgga     4800

tgcgaagccc aagatctgta ctaa                                            4824


<210>  16
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A1MB2 ENHANCER

<400>  16
ggccccaggt taatttttaa aaagcagtca aaggtcaaag tggcccttgg cagcatttac       60

tctctctatt gactttggtt aataatctca ggagcacaaa cattcctgga ggcaggagaa      120

gaaatcaaca tcctggactt atcctctggg cctctcccca ccttcgatgg ccccaggtta      180

atttttaaaa agcagtcaaa ggtcaaagtg gcccttggca gcatttactc tctctattga      240

ctttggttaa taatctcagg agcacaaaca ttcctggagg caggagaaga aatcaacatc      300

ctggacttat cctctgggcc tctccccacc                                       330


<210>  17
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mTTR promoter

<400>  17
gatatctacc tgctgatcgc ccggcccctg ttcaaacatg tcctaatact ctgtcggggc       60

aaaggtcggc agtagttttc catcttactc aacatcctcc cagtgtacgt aggatcctgt      120

ctgtctgcac atttcgtaga gcgagtgttc cgatactcta atctcccggg gcaaaggtcg      180

tattgactta ggttacttat tctccttttg ttgactaagt caataatcag aatcagcagg      240

tttggagtca gcttggcagg gatcagcagc ctgggttgga aggagggggt ataaaagccc      300

cttcaccagg agaagccgtc acacagatcc acaagctcct gctag                      345


<210>  18
<211>  1489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERIC INTRON

<400>  18
tcaggagcac aaacattcct ggaggcagga gaagaaatca acatcctgga cttatcctct       60

gggcctctcc ccaccgatat ctacctgctg atcgcccggc ccctgttcaa acatgtccta      120

atactctgtc ggggcaaagg tcggcagtag ttttccatct tactcaacat cctcccagtg      180

tacgtaggat cctgtctgtc tgcacatttc gtagagcgag tgttccgata ctctaatctc      240

ccggggcaaa ggtcgtattg acttaggtta cttattctcc ttttgttgac taagtcaata      300

atcagaatca gcaggtttgg agtcagcttg gcagggatca gcagcctggg ttggaaggag      360

ggggtataaa agccccttca ccaggagaag ccgtcacaca gatccacaag ctcctgctag      420

agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc      480

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      540

gggctgtaat tagcgcttgg tttattgacg gcttgtttct tttctgtggc tgcgtgaaag      600

ccttgagggg ctccgggaag gccctttgtg cggggggagc ggctcggggg gtgcgtgcgt      660

gtgtgtgtgc gtggggagcg ccgcgtgcgg ctccgcgctg cccggcggct gtgagcgctg      720

cgggcgcggc gcggggcttt gtgcgctccg cagtgtgcgc gaggggagcg cggccggggg      780

cggtgccccg cggtgcgggg ggggctgcga ggggaacaaa ggctgcgtgc ggggtgtgtg      840

cgtggggggg tgagcagggg gtgtgggcgc gtcggtcggg ctgcaacccc ccctgcaccc      900

ccctccccga gttgctgagc acggcccggc ttcgggtgcg gggctccgta cggggcgtgg      960

cgcggggctc gccgtgccgg gcggggggtg gcggcaggtg ggggtgccgg gcggggcggg     1020

gccgcctcgg gccggggagg gctcggggga ggggcgcggc ggcccccgga gcgccggcgg     1080

ctgtcgaggc gcggcgagcc gcagccattg ccttttatgg taatcgtgcg agagggcgca     1140

gggacttcct ttgtcccaaa tctgtgcgga gccgaaatct gggaggcgcc gccgcacccc     1200

ctctagcggg cgcggggcga agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg     1260

ccttcgtgcg tcgccgcgcc gccgtcccct tctccctctc cagcctcggg gctgtccgcg     1320

gggggacggc tgccttcggg ggggacgggg cagggcgggg ttcggcttct ggcgtgtgac     1380

cggcggctct agagcctctg ctaaccttgt tcttgccttc ttctttttcc tacagctcct     1440

gggcaacgtg ctggttattg tgctgtctca tcattttggc aaagaatta                 1489


<210>  19
<211>  595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  19
tcataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt       60

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc      120

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga      180

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc      240

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct      300

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg      360

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct      420

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc      480

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg      540

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgctg           595


<210>  20
<211>  211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bGHpA

<400>  20
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg a                                     211


<210>  21
<211>  4317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of coFVIII-6

<400>  21
gccactcgcc ggtactacct tggagccgtg gagctttcat gggactacat gcagagcgac       60

ctgggcgaac tccccgtgga tgccagattc cccccccgcg tgccaaagtc cttccccttt      120

aacacctccg tggtgtacaa gaaaaccctc tttgtcgagt tcactgacca cctgttcaac      180

atcgccaagc cgcgcccacc ttggatgggc ctcctgggac cgaccattca agctgaagtg      240

tacgacaccg tggtgatcac cctgaagaac atggcgtccc accccgtgtc cctgcatgcg      300

gtcggagtgt cctactggaa ggcctccgaa ggagctgagt acgacgacca gactagccag      360

cgggaaaagg aggacgataa agtgttcccg ggcggctcgc atacttacgt gtggcaagtc      420

ctgaaggaaa acggacctat ggcatccgat cctctgtgcc tgacttactc ctacctttcc      480

catgtggacc tcgtgaagga cctgaacagc gggctgattg gtgcacttct cgtgtgccgc      540

gaaggttcgc tcgctaagga aaagacccag accctccata agttcatcct tttgttcgct      600

gtgttcgatg aaggaaagtc atggcattcc gaaactaaga actcgctgat gcaggaccgg      660

gatgccgcct cagcccgcgc ctggcctaaa atgcatacag tcaacggata cgtgaatcgg      720

tcactgcccg ggctcatcgg ttgtcacaga aagtccgtgt actggcacgt catcggcatg      780

ggcactacgc ctgaagtgca ctccatcttc ctggaagggc acaccttcct cgtgcgcaac      840

caccgccagg cctctctgga aatctccccg attacctttc tgaccgccca gactctgctc      900

atggacctgg ggcagttcct tctcttctgc cacatctcca gccatcagca cgacggaatg      960

gaggcctacg tgaaggtgga ctcatgcccg gaagaacctc agttgcggat gaagaacaac     1020

gaggaggccg aggactatga cgacgatttg actgactccg agatggacgt cgtgcggttc     1080

gatgacgaca acagccccag cttcatccag attcgcagcg tggccaagaa gcaccccaaa     1140

acctgggtgc actacatcgc ggccgaggaa gaagattggg actacgcccc gttggtgctg     1200

gcacccgatg accggtcgta caagtcccag tatctgaaca atggtccgca gcggattggc     1260

agaaagtaca agaaagtgcg gttcatggcg tacactgacg aaacgtttaa gacccgggag     1320

gccattcaac atgagagcgg cattctggga ccactgctgt acggagaggt cggcgatacc     1380

ctgctcatca tcttcaaaaa ccaggcctcc cggccttaca acatctaccc tcacggaatc     1440

accgacgtgc ggccactcta ctcgcggcgc ctgccgaagg gcgtcaagca cctgaaagac     1500

ttccctatcc tgccgggcga aatcttcaag tataagtgga ccgtcaccgt ggaggacggg     1560

cccaccaaga gcgatcctag gtgtctgact cggtactact ccagcttcgt gaacatggaa     1620

cgggacctgg catcgggact cattggaccg ctgctgatct gctacaaaga gtcggtggat     1680

caacgcggca accagatcat gtccgacaag cgcaacgtga tcctgttctc cgtgtttgat     1740

gaaaacagat cctggtacct cactgaaaac atccagaggt tcctcccaaa ccccgcagga     1800

gtgcaactgg aggaccctga gtttcaggcc tcgaatatca tgcactcgat taacggttac     1860

gtgttcgact cgctgcagct gagcgtgtgc ctccatgaag tcgcttactg gtacattctg     1920

tccatcggcg cccagactga cttcctgagc gtgttctttt ccggttacac ctttaagcac     1980

aagatggtgt acgaagatac cctgaccctg ttccctttct ccggcgaaac ggtgttcatg     2040

tcgatggaga acccgggtct gtggattctg ggatgccaca acagcgactt tcggaaccgc     2100

ggaatgactg ccctgctgaa ggtgtcctca tgcgacaaga acaccggaga ctactacgag     2160

gactcctacg aggatatctc agcctacctc ctgtccaaga acaacgcgat cgagccgcgc     2220

agcttcagcc agaacccgcc tgtgctgaag aggcaccagc gagaaattac ccggaccacc     2280

ctccaatcgg atcaggagga aatcgactac gacgacacca tctcggtgga aatgaagaag     2340

gaagatttcg atatctacga cgaggacgaa aatcagtccc ctcgctcatt ccaaaagaaa     2400

actagacact actttatcgc cgcggtggaa agactgtggg actatggaat gtcatccagc     2460

cctcacgtcc ttcggaaccg ggcccagagc ggatcggtgc ctcagttcaa gaaagtggtg     2520

ttccaggagt tcaccgacgg cagcttcacc cagccgctgt accggggaga actgaacgaa     2580

cacctgggcc tgctcggtcc ctacatccgc gcggaagtgg aggataacat catggtgacc     2640

ttccgtaacc aagcatccag accttactcc ttctattcct ccctgatctc atacgaggag     2700

gaccagcgcc aaggcgccga gccccgcaag aacttcgtca agcccaacga gactaagacc     2760

tacttctgga aggtccaaca ccatatggcc ccgaccaagg atgagtttga ctgcaaggcc     2820

tgggcctact tctccgacgt ggaccttgag aaggatgtcc attccggcct gatcgggccg     2880

ctgctcgtgt gtcacaccaa caccctgaac ccagcgcatg gacgccaggt caccgtccag     2940

gagtttgctc tgttcttcac catttttgac gaaactaagt cctggtactt caccgagaat     3000

atggagcgaa actgtagagc gccctgcaat atccagatgg aagatccgac tttcaaggag     3060

aactatagat tccacgccat caacgggtac atcatggata ctctgccggg gctggtcatg     3120

gcccaggatc agaggattcg gtggtacttg ctgtcaatgg gatcgaacga aaacattcac     3180

tccattcact tctccggtca cgtgttcact gtgcgcaaga aggaggagta caagatggcg     3240

ctgtacaatc tgtaccccgg ggtgttcgaa actgtggaga tgctgccgtc caaggccggc     3300

atctggagag tggagtgcct gatcggagag cacctccacg cggggatgtc caccctcttc     3360

ctggtgtact cgaataagtg ccagaccccg ctgggcatgg cctcgggcca catcagagac     3420

ttccagatca cagcaagcgg acaatacggc caatgggcgc cgaagctggc ccgcttgcac     3480

tactccggat cgatcaacgc atggtccacc aaggaaccgt tctcgtggat taaggtggac     3540

ctcctggccc ctatgattat ccacggaatt aagacccagg gcgccaggca gaagttctcc     3600

tccctgtaca tctcgcaatt catcatcatg tacagcctgg acgggaagaa gtggcagact     3660

tacaggggaa actccaccgg caccctgatg gtctttttcg gcaacgtgga ttcctccggc     3720

attaagcaca acatcttcaa cccaccgatc atagccagat atattaggct ccaccccact     3780

cactactcaa tccgctcaac tcttcggatg gaactcatgg ggtgcgacct gaactcctgc     3840

tccatgccgt tggggatgga atcaaaggct attagcgacg cccagatcac cgcgagctcc     3900

tacttcacta acatgttcgc cacctggagc ccctccaagg ccaggctgca cttgcaggga     3960

cggtcaaatg cctggcggcc gcaagtgaac aatccgaagg aatggcttca agtggatttc     4020

caaaagacca tgaaagtgac cggagtcacc acccagggag tgaagtccct tctgacctcg     4080

atgtatgtga aggagttcct gattagcagc agccaggacg ggcaccagtg gaccctgttc     4140

ttccaaaacg gaaaggtcaa ggtgttccag gggaaccagg actcgttcac acccgtggtg     4200

aactccctgg accccccact gctgacgcgg tacttgagga ttcatcctca gtcctgggtc     4260

catcagattg cattgcgaat ggaagtcctg ggctgcgagg cccaggacct gtactga        4317


<210>  22
<211>  4335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding

       B-domain deleted (BDD) codon-optimized human Factor VIII 
       (BDDcoFVIII)

(no XTEN)

<400>  22
gccacccgcc ggtattactt aggtgctgtg gaactgagct gggactacat gcagtccgac       60

ctgggagaac tgccggtgga cgcgagattc ccacctagag tcccgaagtc cttcccattc      120

aacacctccg tggtctacaa aaagaccctg ttcgtggagt tcactgacca ccttttcaat      180

attgccaagc cgcgcccccc ctggatgggc ctgcttggtc ctacgatcca agcagaggtc      240

tacgacaccg tggtcatcac actgaagaac atggcctcac accccgtgtc gctgcatgct      300

gtgggagtgt cctactggaa ggcctcagag ggtgccgaat atgatgacca gaccagccag      360

agggaaaagg aggatgacaa agtgttcccg ggtggcagcc acacttacgt gtggcaagtg      420

ctgaaggaaa acgggcctat ggcgtcggac cccctatgcc tgacctactc ctacctgtcc      480

catgtggacc ttgtgaagga tctcaactcg ggactgatcg gcgccctctt ggtgtgcaga      540

gaaggcagcc tggcgaagga aaagactcag accctgcaca agttcattct gttgtttgct      600

gtgttcgatg aaggaaagtc ctggcactca gaaaccaaga actcgctgat gcaggataga      660

gatgcggcct cggccagagc ctggcctaaa atgcacaccg tcaacggata tgtgaacagg      720

tcgctccctg gcctcatcgg ctgccacaga aagtccgtgt attggcatgt gatcggcatg      780

ggtactactc cggaagtgca tagtatcttt ctggagggcc ataccttctt ggtgcgcaac      840

cacagacagg cctcgctgga aatctcgcct atcactttct tgactgcgca gaccctcctt      900

atggaccttg gacagttcct gctgttctgt cacatcagct cccatcagca tgatgggatg      960

gaggcctatg tcaaagtgga ctcctgccct gaggagccac agctccggat gaagaacaat     1020

gaggaagcgg aggattacga cgacgacctg actgacagcg aaatggacgt cgtgcgattc     1080

gatgacgaca acagcccgtc cttcatccaa attagatcag tggcgaagaa gcaccccaag     1140

acctgggtgc actacattgc cgccgaggaa gaggactggg actacgcgcc gctggtgctg     1200

gcgccagacg acaggagcta caagtcccag tacctcaaca acgggccgca gcgcattggc     1260

aggaagtaca agaaagtccg cttcatggcc tacactgatg aaaccttcaa gacgagggaa     1320

gccatccagc acgagtcagg catcctggga ccgctccttt acggcgaagt cggggatacc     1380

ctgctcatca ttttcaagaa ccaggcatcg cggccctaca acatctaccc tcacgggatc     1440

acagacgtgc gcccgctcta ctcccgccgg ctgcccaagg gagtgaagca cctgaaggat     1500

tttcccatcc tgccgggaga aatcttcaag tacaagtgga ccgtgactgt ggaagatggc     1560

cctaccaagt cggaccctcg ctgtctgacc cggtactatt cctcgtttgt gaacatggag     1620

cgcgacctgg cctcggggct gattggtccg ctgctgatct gctacaagga gtccgtggac     1680

cagcgcggga accagatcat gtccgacaag cgcaacgtga tcctgttctc tgtctttgat     1740

gaaaacagat cgtggtactt gactgagaat atccagcggt tcctgcccaa cccagcggga     1800

gtgcaactgg aggacccgga gttccaggcc tcaaacatta tgcactctat caacggctat     1860

gtgttcgact cgctccaact gagcgtgtgc ctgcatgaag tggcatactg gtacattctg     1920

tccatcggag cccagaccga cttcctgtcc gtgttcttct ccggatacac cttcaagcat     1980

aagatggtgt acgaggacac tctgaccctc ttcccatttt ccggagaaac tgtgttcatg     2040

tcaatggaaa acccgggctt gtggattctg ggttgccata actcggactt ccggaataga     2100

gggatgaccg ccctgctgaa agtgtccagc tgtgacaaga ataccggcga ttactacgag     2160

gacagctatg aggacatctc cgcttatctg ctgtccaaga acaacgccat tgaacccagg     2220

tccttctccc aaaacggtgc accggcctca tccccccccg tgctgaagcg gcatcaaaga     2280

gagatcacca ggaccactct ccagtccgat caggaagaaa ttgactacga cgatactatc     2340

agcgtggaga tgaagaagga ggacttcgac atctacgatg aggatgagaa ccagtcccct     2400

cggagctttc agaagaaaac ccgccactac ttcatcgctg ccgtggagcg gctgtgggat     2460

tacgggatgt ccagctcacc gcatgtgctg cggaatagag cgcagtcagg atcggtgccc     2520

cagttcaaga aggtcgtgtt ccaagagttc accgacgggt ccttcactca acccctgtac     2580

cggggcgaac tcaacgaaca cctgggactg cttgggccgt atatcagggc agaagtggaa     2640

gataacatca tggtcacctt ccgcaaccag gcctcccggc cgtacagctt ctactcttca     2700

ctgatctcct acgaggaaga tcagcggcag ggagccgagc cccggaagaa cttcgtcaag     2760

cctaacgaaa ctaagaccta cttttggaag gtccagcatc acatggcccc gaccaaagac     2820

gagttcgact gtaaagcctg ggcctacttc tccgatgtgg acctggagaa ggacgtgcac     2880

tcgggactca ttggcccgct ccttgtgtgc catactaata ccctgaaccc tgctcacggt     2940

cgccaagtca cagtgcagga gttcgccctc ttcttcacca tcttcgatga aacaaagtcc     3000

tggtacttta ctgagaacat ggaacgcaat tgcagggcac cctgcaacat ccagatggaa     3060

gatcccacct tcaaggaaaa ctaccggttt catgccatta acggctacat aatggacacg     3120

ttgccaggac tggtcatggc ccaggaccag agaatccggt ggtatctgct ctccatgggc     3180

tccaacgaaa acattcacag cattcatttt tccggccatg tgttcaccgt ccggaagaag     3240

gaagagtaca agatggctct gtacaacctc taccctggag tgttcgagac tgtggaaatg     3300

ctgcctagca aggccggcat ttggagagtg gaatgcctga tcggagagca tttgcacgcc     3360

ggaatgtcca ccctgtttct tgtgtactcc aacaagtgcc agaccccgct gggaatggcc     3420

tcaggtcata ttagggattt ccagatcact gcttcggggc agtacgggca gtgggcacct     3480

aagttggccc ggctgcacta ctctggctcc atcaatgcct ggtccaccaa ggaacccttc     3540

tcctggatta aggtggacct cctggcccca atgattattc acggtattaa gacccagggt     3600

gcccgacaga agttctcctc actctacatc tcgcaattca tcataatgta cagcctggat     3660

gggaagaagt ggcagaccta ccggggaaac tccactggaa cgctcatggt gtttttcggc     3720

aacgtggact cctccggcat taagcacaac atcttcaacc ctccgatcat tgctcggtac     3780

atccggctgc acccaactca ctacagcatc cggtccaccc tgcggatgga actgatgggt     3840

tgtgacctga actcctgctc catgcccctt gggatggaat ccaaggccat tagcgatgca     3900

cagatcaccg cctcttcata cttcaccaac atgttcgcga cctggtcccc gtcgaaggcc     3960

cgcctgcacc tccaaggtcg ctccaatgcg tggcggcctc aagtgaacaa ccccaaggag     4020

tggctccagg tcgacttcca aaagaccatg aaggtcaccg gagtgaccac ccagggcgtg     4080

aagtccctgc tgacctctat gtacgttaag gagttcctca tctcctcaag ccaagacgga     4140

catcagtgga ccctgttctt ccaaaacgga aaagtcaaag tattccaggg caaccaggac     4200

tccttcaccc ctgtggtcaa cagcctggac cccccattgc tgacccgcta cctccgcatc     4260

cacccccaaa gctgggtcca ccagatcgca ctgcgcatgg aggtccttgg atgcgaagcc     4320

caagatctgt actaa                                                      4335


<210>  23
<211>  4824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V1.0expression cassette

<400>  23
atgcagattg agctgtccac ttgtttcttc ctgtgcctcc tgcgcttctg tttctccgcc       60

actcgccggt actaccttgg agccgtggag ctttcatggg actacatgca gagcgacctg      120

ggcgaactcc ccgtggatgc cagattcccc ccccgcgtgc caaagtcctt cccctttaac      180

acctccgtgg tgtacaagaa aaccctcttt gtcgagttca ctgaccacct gttcaacatc      240

gccaagccgc gcccaccttg gatgggcctc ctgggaccga ccattcaagc tgaagtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gcgtcccacc ccgtgtccct gcatgcggtc      360

ggagtgtcct actggaaggc ctccgaagga gctgagtacg acgaccagac tagccagcgg      420

gaaaaggagg acgataaagt gttcccgggc ggctcgcata cttacgtgtg gcaagtcctg      480

aaggaaaacg gacctatggc atccgatcct ctgtgcctga cttactccta cctttcccat      540

gtggacctcg tgaaggacct gaacagcggg ctgattggtg cacttctcgt gtgccgcgaa      600

ggttcgctcg ctaaggaaaa gacccagacc ctccataagt tcatcctttt gttcgctgtg      660

ttcgatgaag gaaagtcatg gcattccgaa actaagaact cgctgatgca ggaccgggat      720

gccgcctcag cccgcgcctg gcctaaaatg catacagtca acggatacgt gaatcggtca      780

ctgcccgggc tcatcggttg tcacagaaag tccgtgtact ggcacgtcat cggcatgggc      840

actacgcctg aagtgcactc catcttcctg gaagggcaca ccttcctcgt gcgcaaccac      900

cgccaggcct ctctggaaat ctccccgatt acctttctga ccgcccagac tctgctcatg      960

gacctggggc agttccttct cttctgccac atctccagcc atcagcacga cggaatggag     1020

gcctacgtga aggtggactc atgcccggaa gaacctcagt tgcggatgaa gaacaacgag     1080

gaggccgagg actatgacga cgatttgact gactccgaga tggacgtcgt gcggttcgat     1140

gacgacaaca gccccagctt catccagatt cgcagcgtgg ccaagaagca ccccaaaacc     1200

tgggtgcact acatcgcggc cgaggaagaa gattgggact acgccccgtt ggtgctggca     1260

cccgatgacc ggtcgtacaa gtcccagtat ctgaacaatg gtccgcagcg gattggcaga     1320

aagtacaaga aagtgcggtt catggcgtac actgacgaaa cgtttaagac ccgggaggcc     1380

attcaacatg agagcggcat tctgggacca ctgctgtacg gagaggtcgg cgataccctg     1440

ctcatcatct tcaaaaacca ggcctcccgg ccttacaaca tctaccctca cggaatcacc     1500

gacgtgcggc cactctactc gcggcgcctg ccgaagggcg tcaagcacct gaaagacttc     1560

cctatcctgc cgggcgaaat cttcaagtat aagtggaccg tcaccgtgga ggacgggccc     1620

accaagagcg atcctaggtg tctgactcgg tactactcca gcttcgtgaa catggaacgg     1680

gacctggcat cgggactcat tggaccgctg ctgatctgct acaaagagtc ggtggatcaa     1740

cgcggcaacc agatcatgtc cgacaagcgc aacgtgatcc tgttctccgt gtttgatgaa     1800

aacagatcct ggtacctcac tgaaaacatc cagaggttcc tcccaaaccc cgcaggagtg     1860

caactggagg accctgagtt tcaggcctcg aatatcatgc actcgattaa cggttacgtg     1920

ttcgactcgc tgcaactgag cgtgtgcctc catgaagtcg cttactggta cattctgtcc     1980

atcggcgccc agactgactt cctgagcgtg ttcttttccg gttacacctt taagcacaag     2040

atggtgtacg aagataccct gaccctgttc cctttctccg gcgaaacggt gttcatgtcg     2100

atggagaacc cgggtctgtg gattctggga tgccacaaca gcgactttcg gaaccgcgga     2160

atgactgccc tgctgaaggt gtcctcatgc gacaagaaca ccggagacta ctacgaggac     2220

tcctacgagg atatctcagc ctacctcctg tccaagaaca acgcgatcga gccgcgcagc     2280

ttcagccaga acggcgcgcc aacatcagag agcgccaccc ctgaaagtgg tcccgggagc     2340

gagccagcca catctgggtc ggaaacgcca ggcacaagtg agtctgcaac tcccgagtcc     2400

ggacctggct ccgagcctgc cactagcggc tccgagactc cgggaacttc cgagagcgct     2460

acaccagaaa gcggacccgg aaccagtacc gaacctagcg agggctctgc tccgggcagc     2520

ccagccggct ctcctacatc cacggaggag ggcacttccg aatccgccac cccggagtca     2580

gggccaggat ctgaacccgc tacctcaggc agtgagacgc caggaacgag cgagtccgct     2640

acaccggaga gtgggccagg gagccctgct ggatctccta cgtccactga ggaagggtca     2700

ccagcgggct cgcccaccag cactgaagaa ggtgcctcga gcccgcctgt gctgaagagg     2760

caccagcgag aaattacccg gaccaccctc caatcggatc aggaggaaat cgactacgac     2820

gacaccatct cggtggaaat gaagaaggaa gatttcgata tctacgacga ggacgaaaat     2880

cagtcccctc gctcattcca aaagaaaact agacactact ttatcgccgc ggtggaaaga     2940

ctgtgggact atggaatgtc atccagccct cacgtccttc ggaaccgggc ccagagcgga     3000

tcggtgcctc agttcaagaa agtggtgttc caggagttca ccgacggcag cttcacccag     3060

ccgctgtacc ggggagaact gaacgaacac ctgggcctgc tcggtcccta catccgcgcg     3120

gaagtggagg ataacatcat ggtgaccttc cgtaaccaag catccagacc ttactccttc     3180

tattcctccc tgatctcata cgaggaggac cagcgccaag gcgccgagcc ccgcaagaac     3240

ttcgtcaagc ccaacgagac taagacctac ttctggaagg tccaacacca tatggccccg     3300

accaaggatg agtttgactg caaggcctgg gcctacttct ccgacgtgga ccttgagaag     3360

gatgtccatt ccggcctgat cgggccgctg ctcgtgtgtc acaccaacac cctgaaccca     3420

gcgcatggac gccaggtcac cgtccaggag tttgctctgt tcttcaccat ttttgacgaa     3480

actaagtcct ggtacttcac cgagaatatg gagcgaaact gtagagcgcc ctgcaatatc     3540

cagatggaag atccgacttt caaggagaac tatagattcc acgccatcaa cgggtacatc     3600

atggatactc tgccggggct ggtcatggcc caggatcaga ggattcggtg gtacttgctg     3660

tcaatgggat cgaacgaaaa cattcactcc attcacttct ccggtcacgt gttcactgtg     3720

cgcaagaagg aggagtacaa gatggcgctg tacaatctgt accccggggt gttcgaaact     3780

gtggagatgc tgccgtccaa ggccggcatc tggagagtgg agtgcctgat cggagagcac     3840

ctccacgcgg ggatgtccac cctcttcctg gtgtactcga ataagtgcca gaccccgctg     3900

ggcatggcct cgggccacat cagagacttc cagatcacag caagcggaca atacggccaa     3960

tgggcgccga agctggcccg cttgcactac tccggatcga tcaacgcatg gtccaccaag     4020

gaaccgttct cgtggattaa ggtggacctc ctggccccta tgattatcca cggaattaag     4080

acccagggcg ccaggcagaa gttctcctcc ctgtacatct cgcaattcat catcatgtac     4140

agcctggacg ggaagaagtg gcagacttac aggggaaact ccaccggcac cctgatggtc     4200

tttttcggca acgtggattc ctccggcatt aagcacaaca tcttcaaccc accgatcata     4260

gccagatata ttaggctcca ccccactcac tactcaatcc gctcaactct tcggatggaa     4320

ctcatggggt gcgacctgaa ctcctgctcc atgccgttgg ggatggaatc aaaggctatt     4380

agcgacgccc agatcaccgc gagctcctac ttcactaaca tgttcgccac ctggagcccc     4440

tccaaggcca ggctgcactt gcagggacgg tcaaatgcct ggcggccgca agtgaacaat     4500

ccgaaggaat ggcttcaagt ggatttccaa aagaccatga aagtgaccgg agtcaccacc     4560

cagggagtga agtcccttct gacctcgatg tatgtgaagg agttcctgat tagcagcagc     4620

caggacgggc accagtggac cctgttcttc caaaacggaa aggtcaaggt gttccagggg     4680

aaccaggact cgttcacacc cgtggtgaac tccctggacc ccccactgct gacgcggtac     4740

ttgaggattc atcctcagtc ctgggtccat cagattgcat tgcgaatgga agtcctgggc     4800

tgcgaggccc aggacctgta ctga                                            4824


