                         SEQUENCE LISTING

<110>  UNIVERSITY OF ARIZONA
       WON, Youngwook
       CHA, Byeong Hyun
       BULL, David
 
<120>  HYBRID ALLOSTERIC RECEPTOR-ENGINEERED MESENCHYMAL STEM CELLS

<130>  212443-9010-WO01

<150>  US 63/070,427
<151>  2020-08-26

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  2265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(63)
<223>  Leader Sequence

<220>
<221>  misc_feature
<222>  (64)..(201)
<223>  CXCR4 domain

<220>
<221>  misc_feature
<222>  (202)..(336)
<223>  CD8 hinge domain

<220>
<221>  misc_feature
<222>  (337)..(408)
<223>  CD8 transmembrane domain

<220>
<221>  misc_feature
<222>  (409)..(1311)
<223>  BMPRII domain

<220>
<221>  misc_feature
<222>  (1312)..(1347)
<223>  Glycine linker

<220>
<221>  misc_feature
<222>  (1348)..(2262)
<223>  ALK3 domain

<400>  1
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcaagg       60

cctatggagg gcatctccat ctacacatct gacaattata ccgaggagat gggctccggc      120

gactacgatt ctatgaagga gccctgcttc cgcgaggaga acgccaactt caacaagatt      180

ttcctgccta caatctattc caccacaacc ccagcacccc ggccccctac acctgcacca      240

accatcgcca gccagcctct gtccctgagg ccagaggcct gccgccccgc agcaggagga      300

gcagtgcaca cccgcggcct ggactttgcc tgcgacatct acatctgggc accactggcc      360

ggcacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtattgtaa gctgctggag      420

ctgatcggaa ggggccgcta cggagccgtg tataagggca gcctggacga gaggcctgtg      480

gcagtgaagg tgttctcctt tgccaatcgg cagaacttca tcaatgagaa gaacatctac      540

agagtgccac tgatggagca cgataatatc gccaggttta tcgtgggcga cgagagggtg      600

acagcagatg gacgcatgga gtacctgctg gtcatggagt actatcccaa cggcagcctg      660

tgcaagtatc tgtctctgca caccagcgac tgggtgagca gctgtaggct ggcccactcc      720

gtgacacgcg gcctggccta cctgcacacc gagctgccaa gaggcgacca ctataagccc      780

gccatcagcc accgggacct gaacagccgg aacgtgctgg tgaagaatga cggcacatgc      840

gtgatcagcg atttcggcct gtccatgagg ctgaccggaa ataggctggt gcgcccagga      900

gaggaggata acgcagccat ctctgaagtg ggcacaatca gatacatggc accagaggtg      960

ctggagggag cagtgaacct gagggactgc gagagcgccc tgaagcaggt ggatatgtac     1020

gccctgggcc tgatctattg ggagattttc atgagatgta ccgacctgtt tcctggcgag     1080

tccgtgccag agtatcagat ggccttccag acagaagtgg gcaatcaccc tacctttgag     1140

gatatgcagg tgctggtgtc tcgggagaag cagagaccca agttccctga ggcctggaag     1200

gagaactctc tggccgtgag gagcctgaag gagacaatcg aggactgctg ggaccaggat     1260

gcagaggcaa ggctgaccgc acagtgtgca gaggagagga tggcagagct gggaggaggc     1320

tccggaggag gctctggcgg cggcagcaga accatcgcca agcagatcca gatggtgcgg     1380

caagtgggca agggcagata cggcgaagtg tggatgggca agtggagggg cgagaaggtg     1440

gccgtgaagg tgttctttac aaccgaggag gcctcctggt tccgcgagac agaaatctac     1500

cagaccgtgc tgatgcggca cgagaatatc ctgggcttta tcgccgccga catcaagggc     1560

acaggctctt ggacccagct gtacctgatc accgattatc acgagaacgg cagcctgtac     1620

gacttcctga agtgcgccac actggatacc cgcgccctgc tgaagctggc ctactccgcc     1680

gcatgcggac tgtgccacct gcacacagaa atctacggca cccagggcaa gccagcaatc     1740

gcacaccggg acctgaagtc caagaatatc ctgatcaaga agaacggctc ttgctgtatc     1800

gccgatctgg gcctggccgt gaagtttaat agcgacacaa acgaggtgga tgtgcctctg     1860

aacacaaggg tgggcaccaa gcggtacatg gccccagagg tgctggacga gtccctgaat     1920

aagaaccact tccagcccta catcatggcc gacatctact cttttggcct gatcatctgg     1980

gagatggccc ggagatgcat caccggcggc atcgtggagg agtaccagct gccctactat     2040

aatatggtgc catctgaccc cagctatgag gatatgcggg aggtggtgtg cgtgaagcgg     2100

ctgagaccta tcgtgtccaa tcggtggaac tctgacgagt gcctgagagc cgtgctgaag     2160

ctgatgtctg agtgttgggc acacaaccca gccagccggc tgacagccct gagaatcaag     2220

aagaccctgg ccaagatggt ggagagccag gatgtgaaga tttga                     2265


<210>  2
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesis


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  CD8 Leader Sequence

<220>
<221>  MISC_FEATURE
<222>  (22)..(67)
<223>  CXCR4 domain

<220>
<221>  MISC_FEATURE
<222>  (68)..(112)
<223>  CD8 hinge domain

<220>
<221>  MISC_FEATURE
<222>  (113)..(136)
<223>  CD8 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (137)..(437)
<223>  BMPRII domain

<220>
<221>  MISC_FEATURE
<222>  (438)..(449)
<223>  Glycine linker

<220>
<221>  MISC_FEATURE
<222>  (450)..(754)
<223>  ALK3 domain

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn 
            20                  25                  30          


Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro 
        35                  40                  45              


Cys Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr 
    50                  55                  60                  


Ile Tyr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
65                  70                  75                  80  


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                85                  90                  95      


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            100                 105                 110         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        115                 120                 125             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Leu Leu Glu Leu Ile Gly Arg 
    130                 135                 140                 


Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu Arg Pro Val 
145                 150                 155                 160 


Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe Ile Asn Glu 
                165                 170                 175     


Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn Ile Ala Arg 
            180                 185                 190         


Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg Met Glu Tyr 
        195                 200                 205             


Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys Lys Tyr Leu 
    210                 215                 220                 


Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu Ala His Ser 
225                 230                 235                 240 


Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro Arg Gly Asp 
                245                 250                 255     


His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser Arg Asn Val 
            260                 265                 270         


Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe Gly Leu Ser 
        275                 280                 285             


Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu Glu Asp Asn 
    290                 295                 300                 


Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala Leu Lys Gln 
                325                 330                 335     


Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile Phe Met Arg 
            340                 345                 350         


Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr Gln Met Ala 
        355                 360                 365             


Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp Met Gln Val 
    370                 375                 380                 


Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu Ala Trp Lys 
385                 390                 395                 400 


Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile Glu Asp Cys 
                405                 410                 415     


Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys Ala Glu Glu 
            420                 425                 430         


Arg Met Ala Glu Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Ser Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val Gly Lys 
    450                 455                 460                 


Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu Lys Val 
465                 470                 475                 480 


Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe Arg Glu 
                485                 490                 495     


Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile Leu Gly 
            500                 505                 510         


Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln Leu Tyr 
        515                 520                 525             


Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe Leu Lys 
    530                 535                 540                 


Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr Ser Ala 
545                 550                 555                 560 


Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr Gln Gly 
                565                 570                 575     


Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Ile 
            580                 585                 590         


Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Lys 
        595                 600                 605             


Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr Arg Val 
    610                 615                 620                 


Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser Leu Asn 
625                 630                 635                 640 


Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser Phe Gly 
                645                 650                 655     


Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly Ile Val 
            660                 665                 670         


Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp Pro Ser 
        675                 680                 685             


Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg Pro Ile 
    690                 695                 700                 


Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val Leu Lys 
705                 710                 715                 720 


Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu Thr Ala 
                725                 730                 735     


Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln Asp Val 
            740                 745                 750         


Lys Ile 
        


<210>  3
<211>  2271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(63)
<223>  Leader Sequence

<220>
<221>  misc_feature
<222>  (64)..(207)
<223>  CXCR4 domain

<220>
<221>  misc_feature
<222>  (208)..(342)
<223>  CD8 hinge domain

<220>
<221>  misc_feature
<222>  (343)..(414)
<223>  CD8 transmembrane domain

<220>
<221>  misc_feature
<222>  (415)..(1317)
<223>  BMPRII domain

<220>
<221>  misc_feature
<222>  (1318)..(1353)
<223>  Glycine linker

<220>
<221>  misc_feature
<222>  (1354)..(2268)
<223>  ALK3 domain

<400>  3
atggcactgc ctgtgacagc cctgctgctg ccactggccc tgctgctgca cgcagccaga       60

cctatggagg acttcaacat ggagtccgac tctttcgagg atttttggaa gggcgaggat      120

ctgagcaatt actcctatag ctccaccctg ccaccttttc tgctggacgc agcaccatgc      180

gagccagagt ccctggagat caacaagacc acaacccctg caccaagacc acccacacca      240

gcacctacca tcgcctccca gccactgtct ctgaggccag aggcctgtcg ccctgcagca      300

ggaggcgccg tgcacaccag gggcctggac ttcgcctgcg acatctacat ctgggcaccc      360

ctggccggca catgtggcgt gctgctgctg agcctggtca tcaccctgta ttgcaagctg      420

ctggagctga tcggaagggg ccgctacgga gccgtgtata agggctctct ggatgagagg      480

cccgtggccg tgaaggtgtt cagctttgcc aaccggcaga atttcatcaa cgagaagaat      540

atctacagag tgcctctgat ggagcacgac aacatcgcca ggtttatcgt gggcgacgag      600

agggtgacag cagatggacg catggagtac ctgctggtca tggagtacta tcctaatggc      660

tctctgtgca agtatctgag cctgcacacc tccgattggg tgtctagctg taggctggcc      720

cacagcgtga cacgcggcct ggcctacctg cacaccgagc tgcccagagg cgaccactat      780

aagcctgcca tctctcaccg ggatctgaac agcagaaatg tgctggtgaa gaacgacggc      840

acatgcgtga tcagcgattt cggcctgagc atgaggctga ccggaaacag gctggtgcgc      900

cctggagagg aggacaatgc agccatctcc gaagtgggca caatcagata catggcacca      960

gaggtgctgg agggagcagt gaatctgagg gactgcgagt ctgccctgaa gcaggtggat     1020

atgtacgccc tgggcctgat ctattgggag attttcatgc gctgtaccga tctgtttcca     1080

ggcgagagcg tgcccgagta tcagatggcc ttccagacag aagtgggcaa ccacccaacc     1140

tttgaggaca tgcaggtgct ggtgtcccgg gagaagcaga gacctaagtt tccagaggcc     1200

tggaaggaga acagcctggc cgtgcggagc ctgaaggaga caatcgagga ctgctgggac     1260

caggatgcag aggcaaggct gaccgcacag tgtgcagagg agaggatggc agagctggga     1320

ggaggctctg gaggaggcag cggaggcggc tcccgcacca tcgccaagca gatccagatg     1380

gtgcggcaag tgggcaaggg cagatacgga gaagtgtgga tgggcaagtg gaggggagag     1440

aaggtggcag tgaaggtgtt ctttacaacc gaggaggcct cctggttccg cgagacagaa     1500

atctaccaga ccgtgctgat gcggcacgag aacatcctgg gctttatcgc cgccgacatc     1560

aagggcacag gctcctggac ccagctgtac ctgatcaccg attatcacga gaatggctct     1620

ctgtacgact tcctgaagtg cgccacactg gatacccgcg ccctgctgaa gctggcctac     1680

tctgccgcat gcggactgtg ccacctgcac acagaaatct acggcaccca gggcaagcct     1740

gcaatcgcac accgggatct gaagagcaag aacatcctga tcaagaagaa tggctcctgc     1800

tgtatcgccg acctgggcct ggccgtgaag tttaacagcg acacaaatga ggtggatgtg     1860

ccactgaaca caagggtggg caccaagcgg tacatggccc ctgaggtgct ggacgagagc     1920

ctgaacaaga atcacttcca gccatacatc atggccgaca tctactcctt tggcctgatc     1980

atctgggaga tggcccggag atgcatcacc ggcggcatcg tggaggagta ccagctgcca     2040

tactataaca tggtgccctc tgaccctagc tatgaggata tgcgggaggt ggtgtgcgtg     2100

aagcggctga gacccatcgt gagcaaccgg tggaacagcg atgagtgcct gagagccgtg     2160

ctgaagctga tgtccgagtg ttgggcccac aatcccgcct ctcggctgac agccctgaga     2220

atcaagaaga ccctggccaa gatggtggag agccaggacg tgaagatttg a              2271


<210>  4
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesis


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  CD8 Leader Sequence

<220>
<221>  MISC_FEATURE
<222>  (22)..(69)
<223>  CXCR2 domain

<220>
<221>  MISC_FEATURE
<222>  (70)..(114)
<223>  CD8 hinge domain

<220>
<221>  MISC_FEATURE
<222>  (115)..(138)
<223>  CD8 transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (139)..(439)
<223>  BMPRII domain

<220>
<221>  MISC_FEATURE
<222>  (440)..(451)
<223>  Glycine linker

<220>
<221>  MISC_FEATURE
<222>  (452)..(756)
<223>  ALK3 domain

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe 
            20                  25                  30          


Glu Asp Phe Trp Lys Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser 
        35                  40                  45              


Thr Leu Pro Pro Phe Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser 
    50                  55                  60                  


Leu Glu Ile Asn Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
65                  70                  75                  80  


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                85                  90                  95      


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            100                 105                 110         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        115                 120                 125             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Leu Leu Glu Leu Ile 
    130                 135                 140                 


Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu Arg 
145                 150                 155                 160 


Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe Ile 
                165                 170                 175     


Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn Ile 
            180                 185                 190         


Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg Met 
        195                 200                 205             


Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys Lys 
    210                 215                 220                 


Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu Ala 
225                 230                 235                 240 


His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro Arg 
                245                 250                 255     


Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser Arg 
            260                 265                 270         


Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe Gly 
        275                 280                 285             


Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu Glu 
    290                 295                 300                 


Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala Pro 
305                 310                 315                 320 


Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala Leu 
                325                 330                 335     


Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile Phe 
            340                 345                 350         


Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr Gln 
        355                 360                 365             


Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp Met 
    370                 375                 380                 


Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu Ala 
385                 390                 395                 400 


Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile Glu 
                405                 410                 415     


Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys Ala 
            420                 425                 430         


Glu Glu Arg Met Ala Glu Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Ser Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val 
    450                 455                 460                 


Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu 
465                 470                 475                 480 


Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe 
                485                 490                 495     


Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile 
            500                 505                 510         


Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln 
        515                 520                 525             


Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe 
    530                 535                 540                 


Leu Lys Cys Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr 
545                 550                 555                 560 


Ser Ala Ala Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr 
                565                 570                 575     


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile 
            580                 585                 590         


Leu Ile Lys Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala 
        595                 600                 605             


Val Lys Phe Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr 
    610                 615                 620                 


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser 
625                 630                 635                 640 


Leu Asn Lys Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser 
                645                 650                 655     


Phe Gly Leu Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly 
            660                 665                 670         


Ile Val Glu Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp 
        675                 680                 685             


Pro Ser Tyr Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg 
    690                 695                 700                 


Pro Ile Val Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val 
705                 710                 715                 720 


Leu Lys Leu Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu 
                725                 730                 735     


Thr Ala Leu Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln 
            740                 745                 750         


Asp Val Lys Ile 
        755     


<210>  5
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(63)
<223>  Leader Sequence

<220>
<221>  misc_feature
<222>  (64)..(201)
<223>  CXCR4 domain

<220>
<221>  misc_feature
<222>  (202)..(336)
<223>  CD8 hinge domain

<220>
<221>  misc_feature
<222>  (337)..(408)
<223>  CD8 transmembrane domain

<400>  5
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgcagcaagg       60

cctatggagg gcatcagcat ctacacatcc gacaattata ccgaggagat gggctccggc      120

gactacgatt ctatgaagga gccatgcttc agggaggaga acgccaactt caacaagatt      180

ttcctgccca caatctatag caccacaacc ccagcacccc gcccccctac acctgcacca      240

accatcgcct ctcagccact gagcctgagg cctgaggcct gcagaccagc agcaggagga      300

gcagtgcaca ccaggggcct ggactttgcc tgcgacatct acatctgggc acccctggcc      360

ggcacatgtg gcgtgctgct gctgagcctg gtcatcaccc tgtattgttg a               411


<210>  6
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesis


<220>
<221>  MISC_FEATURE
<222>  (1)..(21)
<223>  CD8 Leader Sequence

<220>
<221>  MISC_FEATURE
<222>  (22)..(67)
<223>  CXCR4 domain

<220>
<221>  MISC_FEATURE
<222>  (68)..(112)
<223>  CD8 hinge domain

<220>
<221>  MISC_FEATURE
<222>  (113)..(136)
<223>  CD8 transmembrane domain

<400>  6

Ala Thr Gly Gly Cys Ala Cys Thr Gly Cys Cys Ala Gly Thr Gly Ala 
1               5                   10                  15      


Cys Ala Gly Cys Cys Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Cys 
            20                  25                  30          


Thr Cys Thr Gly Gly Cys Cys Cys Thr Gly Cys Thr Gly Cys Thr Gly 
        35                  40                  45              


Cys Ala Cys Gly Cys Ala Gly Cys Ala Ala Gly Gly Cys Cys Thr Ala 
    50                  55                  60                  


Thr Gly Gly Ala Gly Gly Gly Cys Ala Thr Cys Ala Gly Cys Ala Thr 
65                  70                  75                  80  


Cys Thr Ala Cys Ala Cys Ala Thr Cys Cys Gly Ala Cys Ala Ala Thr 
                85                  90                  95      


Thr Ala Thr Ala Cys Cys Gly Ala Gly Gly Ala Gly Ala Thr Gly Gly 
            100                 105                 110         


Gly Cys Thr Cys Cys Gly Gly Cys Gly Ala Cys Thr Ala Cys Gly Ala 
        115                 120                 125             


Thr Thr Cys Thr Ala Thr Gly Ala Ala Gly Gly Ala Gly Cys Cys Ala 
    130                 135                 140                 


Thr Gly Cys Thr Thr Cys Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala 
145                 150                 155                 160 


Ala Cys Gly Cys Cys Ala Ala Cys Thr Thr Cys Ala Ala Cys Ala Ala 
                165                 170                 175     


Gly Ala Thr Thr Thr Thr Cys Cys Thr Gly Cys Cys Cys Ala Cys Ala 
            180                 185                 190         


Ala Thr Cys Thr Ala Thr Ala Gly Cys Ala Cys Cys Ala Cys Ala Ala 
        195                 200                 205             


Cys Cys Cys Cys Ala Gly Cys Ala Cys Cys Cys Cys Gly Cys Cys Cys 
    210                 215                 220                 


Cys Cys Cys Thr Ala Cys Ala Cys Cys Thr Gly Cys Ala Cys Cys Ala 
225                 230                 235                 240 


Ala Cys Cys Ala Thr Cys Gly Cys Cys Thr Cys Thr Cys Ala Gly Cys 
                245                 250                 255     


Cys Ala Cys Thr Gly Ala Gly Cys Cys Thr Gly Ala Gly Gly Cys Cys 
            260                 265                 270         


Thr Gly Ala Gly Gly Cys Cys Thr Gly Cys Ala Gly Ala Cys Cys Ala 
        275                 280                 285             


Gly Cys Ala Gly Cys Ala Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly 
    290                 295                 300                 


Thr Gly Cys Ala Cys Ala Cys Cys Ala Gly Gly Gly Gly Cys Cys Thr 
305                 310                 315                 320 


Gly Gly Ala Cys Thr Thr Thr Gly Cys Cys Thr Gly Cys Gly Ala Cys 
                325                 330                 335     


Ala Thr Cys Thr Ala Cys Ala Thr Cys Thr Gly Gly Gly Cys Ala Cys 
            340                 345                 350         


Cys Cys Cys Thr Gly Gly Cys Cys Gly Gly Cys Ala Cys Ala Thr Gly 
        355                 360                 365             


Thr Gly Gly Cys Gly Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly 
    370                 375                 380                 


Ala Gly Cys Cys Thr Gly Gly Thr Cys Ala Thr Cys Ala Cys Cys Cys 
385                 390                 395                 400 


Thr Gly Thr Ala Thr Thr Gly Thr Thr Gly Ala 
                405                 410     


<210>  7
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcaagg       60

cct                                                                     63


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  9
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
atggagggca tctccatcta cacatctgac aattataccg aggagatggg ctccggcgac       60

tacgattcta tgaaggagcc ctgcttccgc gaggagaacg ccaacttcaa caagattttc      120

ctgcctacaa tctattcc                                                    138


<210>  10
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser 
        35                  40                  45      


<210>  11
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
atggaggact tcaacatgga gtccgactct ttcgaggatt tttggaaggg cgaggatctg       60

agcaattact cctatagctc caccctgcca ccttttctgc tggacgcagc accatgcgag      120

ccagagtccc tggagatcaa caaga                                            145


<210>  12
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


<210>  13
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
accacaaccc cagcaccccg gccccctaca cctgcaccaa ccatcgccag ccagcctctg       60

tccctgaggc cagaggcctg ccgccccgca gcaggaggag cagtgcacac ccgcggcctg      120

gactttgcct gcgac                                                       135


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  15
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atctacatct gggcaccact ggccggcaca tgtggcgtgc tgctgctgag cctggtcatc       60

accctgtatt gt                                                           72


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  17
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
aagctgctgg agctgatcgg aaggggccgc tacggagccg tgtataaggg cagcctggac       60

gagaggcctg tggcagtgaa ggtgttctcc tttgccaatc ggcagaactt catcaatgag      120

aagaacatct acagagtgcc actgatggag cacgataata tcgccaggtt tatcgtgggc      180

gacgagaggg tgacagcaga tggacgcatg gagtacctgc tggtcatgga gtactatccc      240

aacggcagcc tgtgcaagta tctgtctctg cacaccagcg actgggtgag cagctgtagg      300

ctggcccact ccgtgacacg cggcctggcc tacctgcaca ccgagctgcc aagaggcgac      360

cactataagc ccgccatcag ccaccgggac ctgaacagcc ggaacgtgct ggtgaagaat      420

gacggcacat gcgtgatcag cgatttcggc ctgtccatga ggctgaccgg aaataggctg      480

gtgcgcccag gagaggagga taacgcagcc atctctgaag tgggcacaat cagatacatg      540

gcaccagagg tgctggaggg agcagtgaac ctgagggact gcgagagcgc cctgaagcag      600

gtggatatgt acgccctggg cctgatctat tgggagattt tcatgagatg taccgacctg      660

tttcctggcg agtccgtgcc agagtatcag atggccttcc agacagaagt gggcaatcac      720

cctacctttg aggatatgca ggtgctggtg tctcgggaga agcagagacc caagttccct      780

gaggcctgga aggagaactc tctggccgtg aggagcctga aggagacaat cgaggactgc      840

tgggaccagg atgcagaggc aaggctgacc gcacagtgtg cagaggagag gatggcagag      900

ctg                                                                    903


<210>  18
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Lys Leu Leu Glu Leu Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys 
1               5                   10                  15      


Gly Ser Leu Asp Glu Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala 
            20                  25                  30          


Asn Arg Gln Asn Phe Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu 
        35                  40                  45              


Met Glu His Asp Asn Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val 
    50                  55                  60                  


Thr Ala Asp Gly Arg Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Cys Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val 
                85                  90                  95      


Ser Ser Cys Arg Leu Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu 
            100                 105                 110         


His Thr Glu Leu Pro Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His 
        115                 120                 125             


Arg Asp Leu Asn Ser Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys 
    130                 135                 140                 


Val Ile Ser Asp Phe Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu 
145                 150                 155                 160 


Val Arg Pro Gly Glu Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr 
                165                 170                 175     


Ile Arg Tyr Met Ala Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg 
            180                 185                 190         


Asp Cys Glu Ser Ala Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu 
        195                 200                 205             


Ile Tyr Trp Glu Ile Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu 
    210                 215                 220                 


Ser Val Pro Glu Tyr Gln Met Ala Phe Gln Thr Glu Val Gly Asn His 
225                 230                 235                 240 


Pro Thr Phe Glu Asp Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg 
                245                 250                 255     


Pro Lys Phe Pro Glu Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser 
            260                 265                 270         


Leu Lys Glu Thr Ile Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg 
        275                 280                 285             


Leu Thr Ala Gln Cys Ala Glu Glu Arg Met Ala Glu Leu 
    290                 295                 300     


<210>  19
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gggaggaggc tccggaggag gctctggcgg cggcagc                                37


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  21
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
agaaccatcg ccaagcagat ccagatggtg cggcaagtgg gcaagggcag atacggcgaa       60

gtgtggatgg gcaagtggag gggcgagaag gtggccgtga aggtgttctt tacaaccgag      120

gaggcctcct ggttccgcga gacagaaatc taccagaccg tgctgatgcg gcacgagaat      180

atcctgggct ttatcgccgc cgacatcaag ggcacaggct cttggaccca gctgtacctg      240

atcaccgatt atcacgagaa cggcagcctg tacgacttcc tgaagtgcgc cacactggat      300

acccgcgccc tgctgaagct ggcctactcc gccgcatgcg gactgtgcca cctgcacaca      360

gaaatctacg gcacccaggg caagccagca atcgcacacc gggacctgaa gtccaagaat      420

atcctgatca agaagaacgg ctcttgctgt atcgccgatc tgggcctggc cgtgaagttt      480

aatagcgaca caaacgaggt ggatgtgcct ctgaacacaa gggtgggcac caagcggtac      540

atggccccag aggtgctgga cgagtccctg aataagaacc acttccagcc ctacatcatg      600

gccgacatct actcttttgg cctgatcatc tgggagatgg cccggagatg catcaccggc      660

ggcatcgtgg aggagtacca gctgccctac tataatatgg tgccatctga ccccagctat      720

gaggatatgc gggaggtggt gtgcgtgaag cggctgagac ctatcgtgtc caatcggtgg      780

aactctgacg agtgcctgag agccgtgctg aagctgatgt ctgagtgttg ggcacacaac      840

ccagccagcc ggctgacagc cctgagaatc aagaagaccc tggccaagat ggtggagagc      900

caggatgtga agatttga                                                    918


<210>  22
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Arg Thr Ile Ala Lys Gln Ile Gln Met Val Arg Gln Val Gly Lys Gly 
1               5                   10                  15      


Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu Lys Val Ala 
            20                  25                  30          


Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe Arg Glu Thr 
        35                  40                  45              


Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile Leu Gly Phe 
    50                  55                  60                  


Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln Leu Tyr Leu 
65                  70                  75                  80  


Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Phe Leu Lys Cys 
                85                  90                  95      


Ala Thr Leu Asp Thr Arg Ala Leu Leu Lys Leu Ala Tyr Ser Ala Ala 
            100                 105                 110         


Cys Gly Leu Cys His Leu His Thr Glu Ile Tyr Gly Thr Gln Gly Lys 
        115                 120                 125             


Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Ile Lys 
    130                 135                 140                 


Lys Asn Gly Ser Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Lys Phe 
145                 150                 155                 160 


Asn Ser Asp Thr Asn Glu Val Asp Val Pro Leu Asn Thr Arg Val Gly 
                165                 170                 175     


Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Ser Leu Asn Lys 
            180                 185                 190         


Asn His Phe Gln Pro Tyr Ile Met Ala Asp Ile Tyr Ser Phe Gly Leu 
        195                 200                 205             


Ile Ile Trp Glu Met Ala Arg Arg Cys Ile Thr Gly Gly Ile Val Glu 
    210                 215                 220                 


Glu Tyr Gln Leu Pro Tyr Tyr Asn Met Val Pro Ser Asp Pro Ser Tyr 
225                 230                 235                 240 


Glu Asp Met Arg Glu Val Val Cys Val Lys Arg Leu Arg Pro Ile Val 
                245                 250                 255     


Ser Asn Arg Trp Asn Ser Asp Glu Cys Leu Arg Ala Val Leu Lys Leu 
            260                 265                 270         


Met Ser Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu Thr Ala Leu 
        275                 280                 285             


Arg Ile Lys Lys Thr Leu Ala Lys Met Val Glu Ser Gln Asp Val Lys 
    290                 295                 300                 


Ile 
305 


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
caccggccaa gtgtgcgtct                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
gcagcgcgca cagctctttc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
cggcgaggag gaaggagcca                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
tgggggcaga agacggaggg                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
ggaggagaac aggaggaagg                                                   20


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
ctggatgtaa cccccaaaat gc                                                22


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
cgtgtggaca aggtggatga                                                   20


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
gccgcttaaa cttgcctcg                                                    19


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
ggtgaagcag gcgtcggagg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gagggcaatg ccagccccag                                                   20


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
ccggaagcga ccctcaga                                                     18


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
cggtcaattt tgccaaagat ct                                                22


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ggactgcgcc catcacttac c                                                 21


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
aacttcatcc accggggcta ttac                                              24


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
gccagagatg ctgaagatgg t                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
gcaccaagtt gggcatgaag                                                   20


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
tctctgctcc tccctgttct a                                                 21


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
atgaaggggt cgttgatggc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
caccggccaa gtgtgcgtct                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
gcagcgcgca cagctctttc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
cggcgaggag gaaggagcca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
tgggggcaga agacggaggg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
ggaggagaac aggaggaagg                                                   20


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
ctggatgtaa cccccaaaat gc                                                22


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
cgtgtggaca aggtggatga                                                   20


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gccgcttaaa cttgcctcg                                                    19


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
acccactcct ccacctttga c                                                 21


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
tgttgctgta gccaaattcg tt                                                22


