                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  ONCOLYTIC VIRUSES ENCODING RECOMBINANT TRANFORMING GROWTH FACTOR 
       (TGF)-BETA MONOMERS AND USES THEREOF

<130>  8123-103782-02

<150>  US 63/070,965
<151>  2020-08-27

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  2
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Lys Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  3
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  4
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Ser Cys Val Pro Gln Ala Leu Glu 
    50                  55                  60                  


Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
                85                  90          


<210>  5
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Ser Cys Val Ser Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                85                  90          


<210>  6
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Glu Glu Ser Asp Ser Pro Ser Cys Val Pro Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                85                  90          


<210>  7
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Ser Cys Val Ser Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                85                  90          


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  9
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Arg Cys Arg Ser Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                85                  90          


<210>  10
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Ala Leu Asp Ala Ala Tyr Val Phe Arg Asn Val Gln Asp Asn Cys Ala 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Arg Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Ser Cys Val Ser Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Arg Thr Pro Lys Ile Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                85                  90          


<210>  11
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu Arg 
1               5                   10                  15      


Lys Tyr Leu Lys Ser Asp Trp Cys Lys Leu Arg Pro Leu Tyr Ile Asp 
            20                  25                  30          


Phe Arg Lys Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr 
        35                  40                  45              


Asn Ala Asn Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg 
    50                  55                  60                  


His Val Lys Lys Glu Glu Asp Ser Phe Gln Ser Ser Ala Phe Cys Val 
65                  70                  75                  80  


Ser Gln Asp Leu Glu Pro Leu Thr Ile Val Tyr Tyr Val Gly Arg Lys 
                85                  90                  95      


Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Arg Cys 
            100                 105                 110         


Met Ser Val 
        115 


<210>  12
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Ala Leu Asp Ala Ala Tyr Val Phe Arg Asn Val Gln Asp Asn Cys Ala 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Arg Ala Ser Lys Ser Pro Arg Cys Arg Ser Gln Asp Leu Glu 
    50                  55                  60                  


Pro Leu Thr Ile Val Tyr Tyr Val Gly Arg Lys Pro Lys Val Glu Gln 
65                  70                  75                  80  


Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                85                  90          


