                         SEQUENCE LISTING

<110>  Seattle Children's Hospital d/b/a Seattle Children's 
       Research Institute
 
<120>  COMPOSITIONS AND METHODS FOR TARGETING PLASMODIUM MALE GAMETE 
       PROTEIN TO BLOCK MALARIA PARASITE TRANSMISSION

<130>  3399-P29WO

<150>  63/071,854
<151>  2020-08-28

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  4232
<212>  DNA
<213>  Plasmodium falciparum

<400>  1
atggataggt tgaacaagta tttgtctgtt cttttttttt tcttcttttt cttttttctt       60

aatatctttc aaataaaaac tgaggaaaag cataagtcac ttagcaaaga taacgcttat      120

actttatatt ttaaaaatgt cacaaaaaaa tgattaatac aaataaaagt agaaatatat      180

atatatatat atatagtcat ttatttattt atacttttta tatatttcct caaattgtag      240

agacaaaaat atgtagttcg taggagcgaa ggttctccat acagaaattt tcttttgtat      300

gttgaggaaa tttatcaagt tactgtggtg taccctatta aatatctttt tgttaataaa      360

taaattatat aaaataatat atgcataaat aaatataaat ataaataaat atatatatat      420

atatatatat atatatatta ttgtaaccat tcaataggat attcctctaa aatattatga      480

atatttcaag tcctataaaa agaaagatat agataataaa aatttaaaac aattttgtaa      540

tataattaaa gagcaacatg aaataaataa tgaacaacaa aaatgtttct gttgttattg      600

tcgtcaagat gatatggtat ttccattatt ttctcatttt aattataaaa aagcaaagtt      660

taaatgtaac aagaaaggtg acaataaata tatatgcgtt aacatttctt atacttggct      720

gtatttatat tgttatccat ataatcaagc attaataata tcaatatata tatatatata      780

tatatatatg tgtgtgtata tttatttatt tatttttttt ttttttagaa caagaagagg      840

atatagttct gaccttgtct tgtttgaaaa agaaagacaa aatttttcat tcttttttca      900

tacaacaaaa ttacaacttt tttatgttaa atgttacatt acaacaattt ggtattgtgt      960

tcatataaga tttatacaaa ctgtcttatt atataatatg atatatttat tttatatttt     1020

tttttttttt tttttttttt ctttctctta gatttgaatg acgaatattt cataaacata     1080

aatgtaatat aaacaaaaaa aaaaaaaaaa atatatatat atatatatat ataggtctgt     1140

attaatattt tcgtttatat aaaaatatac aggataagtc tactctagaa agaaaaactt     1200

atctccttga ttcttcaaat tatgaaatag atgacggtat atatataaag aaaaaaaaaa     1260

aaaaaaaata cacaaacaca catatatata tatatatata tatatatata ttatttctct     1320

atatttgagg aaaataagaa atgattaatt attattatta ttattactac aaattgtata     1380

attcaaaaaa tgaatataca tacgatatac ctgcttttct cctttttgca gaagtattta     1440

atgtaaagat aaaatttaat gtccaaaaaa attacagagt aaataataaa aaactataca     1500

tgcatttttg ctattactcc aatatatata tatatatata taaatctaca tttttaaatt     1560

agaatgacga tattgagggc aactaccttt ttgtggactc aaatattttt aaggataggg     1620

ttaaataaaa atataatatt aatttatata tatatttagt aacaaaccca aaaaaaaaaa     1680

aaaaaaaaaa aaaaatatgg ttatatgtaa atattttcct ttgtgttaat attattacag     1740

ataatattag aagactcatt taaaggtaag cctttaattt tttaataaaa taaaaaaaga     1800

aaaacatgta acatatatat atatatatat atttatttat ttatttattt atttatttgt     1860

ggttatgtga atttgttata ttatcctatg gttcattcaa aatatatatt aatttattta     1920

aacattcata tttgaaagat ggagatattt taaaaaattc agttattgta aaatctcatc     1980

atgttgatga acatggactt acatgtaaca aaataattgg ttatccgatt tattggaata     2040

gaggaaaagg attgtgtcga ttaaaaagaa atgaatgttt tcataaacag gtttctacat     2100

ttttaaattt agaaaagaaa ttaagctcga aaaataatat gagctataat tattctttct     2160

ttatgataag aaagttacat atggatgaat ataatgagat agatgaaggt tttgaaaaaa     2220

cgaatgaata tatatataat ataaataaac ttaataaaat aaatgaaata atagatgatt     2280

ataagtataa taatacggat agatataaat atgatattaa gattgataat aatgagaact     2340

tattagaata tataaaaaat aattattata ttggtttaca aaaagaaaga catcatttta     2400

tagatataaa atcacataat gaagaaatat taaatatatc atatgacgag gaaggtatag     2460

gagagtccgt atcctttgta catatattaa gtaattgtta caattataat aatgaaaaaa     2520

aaaatatctc atgtagtatt tatataagta tatggaatga agaagatata gagaaagaaa     2580

taaatgtttt tataaaatgt aaacaaagga ttgttaatga tataacacaa ctaaataaaa     2640

aattattttt atgtaaaaag tgtgaagaaa ctattcttat aaaatttgaa cctatatata     2700

atatgttgct agcatcatgt catgttttaa taacaaaaga ggaaagaaat cttgatataa     2760

aaaatatata tgaagatcct aatattaggg gtgcaaatta taaagagcaa cattttcttt     2820

ttgttaaaga tgaagaaaat gtagaggcat cgcataatta taaatataaa aaaggaaaat     2880

ataaaactta tgattatgat gatgatatgg taaatatgga tcaaagagta caaaataaag     2940

aatatcataa gatagataaa atatataata ataataataa taataataat gataatatat     3000

accacaaaaa tgtatacatt attaaagaag tacctcttaa attcgatgaa caattctata     3060

ggccaaacga tcataacata atgttattat ataatacaat gaactttgtt gaaaatgtag     3120

aagattatat tttaagatat aaaaggaaat tctttttttt tataaacaaa tcagggaata     3180

ttgtaaaaat aattttattc ttattcttag ttattatatt atgtattttt ataataccaa     3240

gtttaccttt ctgtacatat ttttttatta aattaaaatg gtttcataaa ctaaaaacaa     3300

ttcgtctatt gatattatgg aaagtacaag atacattcac attttttaaa aagataccca     3360

ggaaagtatg gagattcata aaaaaaattg caaaaaaatg taaacgggtg ctttttaaaa     3420

tatttataaa atataaaaag gatcaagaac ttattgatca agaatataaa gaaaaattac     3480

aaagaaaaag aaaaaaagaa agaaaaaaaa aacaaatcag aaaaaaatat caacttcaaa     3540

aaaaggagaa ggaaattttg agaaaaaaaa gatataaaaa gttgattgaa aatgaaaaaa     3600

tatttcaaaa ggaaatgaaa aaagaattaa tgcataaaag aaataataaa ataaaacacg     3660

aaaacaaaca tgaagaaaat tattatataa acaacaaaaa tgatcataca tatggtcata     3720

aaagtaaaac gcagaaacat tataaaaaat atcatgataa atatgaagat aaatatcatc     3780

ataaatatca taagaaagaa ccaaaacaaa aaaatatata taatcattta aataatcctc     3840

ataatccatc atataacgat ttagaaaaaa atcaatcatt aacttcaaac acaaattctt     3900

ctcaagaata ttatgaaaag aaaaaatatg aaaatactct ttcatctgct gaacatataa     3960

atataaaaaa cactcatcat aaaagtaaat taaatacttt taataataaa aacacatatg     4020

ataaccaata tattaaaaaa gaaccatatg ataaggataa tatatattct gatttctatg     4080

ctataaaaaa caatgaccaa caaagtattc tccaagaaaa aaagaaaaat agaagaagca     4140

tatccaacat atcaaaaatt tataaaaata atgataccat acaactatct aataaggata     4200

gtaaaactag tagaaaagat cttttaccat aa                                   4232


<210>  2
<211>  999
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Met Asp Arg Leu Asn Lys Tyr Leu Ser Arg Gln Lys Tyr Val Val Arg 
1               5                   10                  15      


Arg Ser Glu Gly Ser Pro Tyr Arg Asn Phe Leu Leu Tyr Val Glu Glu 
            20                  25                  30          


Ile Tyr Gln Val Thr Val Val Tyr Pro Ile Lys Tyr Leu Phe Asp Ile 
        35                  40                  45              


Pro Leu Lys Tyr Tyr Glu Tyr Phe Lys Ser Tyr Lys Lys Lys Asp Ile 
    50                  55                  60                  


Asp Asn Lys Asn Leu Lys Gln Phe Cys Asn Ile Ile Lys Glu Gln His 
65                  70                  75                  80  


Glu Ile Asn Asn Glu Gln Gln Lys Cys Phe Cys Cys Tyr Cys Arg Gln 
                85                  90                  95      


Asp Asp Met Val Phe Pro Leu Phe Ser His Phe Asn Tyr Lys Lys Ala 
            100                 105                 110         


Lys Phe Lys Cys Asn Lys Lys Glu Gln Glu Glu Asp Ile Val Leu Thr 
        115                 120                 125             


Leu Ser Cys Leu Lys Lys Lys Asp Lys Ile Phe His Ser Phe Phe Ile 
    130                 135                 140                 


Gln Gln Asn Tyr Asn Phe Phe Met Leu Asn Val Thr Leu Gln Gln Phe 
145                 150                 155                 160 


Asp Leu Asn Asp Glu Tyr Phe Ile Asn Ile Asn Asp Lys Ser Thr Leu 
                165                 170                 175     


Glu Arg Lys Thr Tyr Leu Leu Asp Ser Ser Asn Tyr Glu Ile Asp Asp 
            180                 185                 190         


Glu Val Phe Asn Val Lys Ile Lys Phe Asn Val Gln Lys Asn Tyr Arg 
        195                 200                 205             


Asn Asp Asp Ile Glu Gly Asn Tyr Leu Phe Val Asp Ser Asn Ile Phe 
    210                 215                 220                 


Lys Asp Arg Ile Ile Leu Glu Asp Ser Phe Lys Asp Gly Asp Ile Leu 
225                 230                 235                 240 


Lys Asn Ser Val Ile Val Lys Ser His His Val Asp Glu His Gly Leu 
                245                 250                 255     


Thr Cys Asn Lys Ile Ile Gly Tyr Pro Ile Tyr Trp Asn Arg Gly Lys 
            260                 265                 270         


Gly Leu Cys Arg Leu Lys Arg Asn Glu Cys Phe His Lys Gln Val Ser 
        275                 280                 285             


Thr Phe Leu Asn Leu Glu Lys Lys Leu Ser Ser Lys Asn Asn Met Ser 
    290                 295                 300                 


Tyr Asn Tyr Ser Phe Phe Met Ile Arg Lys Leu His Met Asp Glu Tyr 
305                 310                 315                 320 


Asn Glu Ile Asp Glu Gly Phe Glu Lys Thr Asn Glu Tyr Ile Tyr Asn 
                325                 330                 335     


Ile Asn Lys Leu Asn Lys Ile Asn Glu Ile Ile Asp Asp Tyr Lys Tyr 
            340                 345                 350         


Asn Asn Thr Asp Arg Tyr Lys Tyr Asp Ile Lys Ile Asp Asn Asn Glu 
        355                 360                 365             


Asn Leu Leu Glu Tyr Ile Lys Asn Asn Tyr Tyr Ile Gly Leu Gln Lys 
    370                 375                 380                 


Glu Arg His His Phe Ile Asp Ile Lys Ser His Asn Glu Glu Ile Leu 
385                 390                 395                 400 


Asn Ile Ser Tyr Asp Glu Glu Gly Ile Gly Glu Ser Val Ser Phe Val 
                405                 410                 415     


His Ile Leu Ser Asn Cys Tyr Asn Tyr Asn Asn Glu Lys Lys Asn Ile 
            420                 425                 430         


Ser Cys Ser Ile Tyr Ile Ser Ile Trp Asn Glu Glu Asp Ile Glu Lys 
        435                 440                 445             


Glu Ile Asn Val Phe Ile Lys Cys Lys Gln Arg Ile Val Asn Asp Ile 
    450                 455                 460                 


Thr Gln Leu Asn Lys Lys Leu Phe Leu Cys Lys Lys Cys Glu Glu Thr 
465                 470                 475                 480 


Ile Leu Ile Lys Phe Glu Pro Ile Tyr Asn Met Leu Leu Ala Ser Cys 
                485                 490                 495     


His Val Leu Ile Thr Lys Glu Glu Arg Asn Leu Asp Ile Lys Asn Ile 
            500                 505                 510         


Tyr Glu Asp Pro Asn Ile Arg Gly Ala Asn Tyr Lys Glu Gln His Phe 
        515                 520                 525             


Leu Phe Val Lys Asp Glu Glu Asn Val Glu Ala Ser His Asn Tyr Lys 
    530                 535                 540                 


Tyr Lys Lys Gly Lys Tyr Lys Thr Tyr Asp Tyr Asp Asp Asp Met Val 
545                 550                 555                 560 


Asn Met Asp Gln Arg Val Gln Asn Lys Glu Tyr His Lys Ile Asp Lys 
                565                 570                 575     


Ile Tyr Asn Asn Asn Asn Asn Asn Asn Asn Asp Asn Ile Tyr His Lys 
            580                 585                 590         


Asn Val Tyr Ile Ile Lys Glu Val Pro Leu Lys Phe Asp Glu Gln Phe 
        595                 600                 605             


Tyr Arg Pro Asn Asp His Asn Ile Met Leu Leu Tyr Asn Thr Met Asn 
    610                 615                 620                 


Phe Val Glu Asn Val Glu Asp Tyr Ile Leu Arg Tyr Lys Arg Lys Phe 
625                 630                 635                 640 


Phe Phe Phe Ile Asn Lys Ser Gly Asn Ile Val Lys Ile Ile Leu Phe 
                645                 650                 655     


Leu Phe Leu Val Ile Ile Leu Cys Ile Phe Ile Ile Pro Ser Leu Pro 
            660                 665                 670         


Phe Cys Thr Tyr Phe Phe Ile Lys Leu Lys Trp Phe His Lys Leu Lys 
        675                 680                 685             


Thr Ile Arg Leu Leu Ile Leu Trp Lys Val Gln Asp Thr Phe Thr Phe 
    690                 695                 700                 


Phe Lys Lys Ile Pro Arg Lys Val Trp Arg Phe Ile Lys Lys Ile Ala 
705                 710                 715                 720 


Lys Lys Cys Lys Arg Val Leu Phe Lys Ile Phe Ile Lys Tyr Lys Lys 
                725                 730                 735     


Asp Gln Glu Leu Ile Asp Gln Glu Tyr Lys Glu Lys Leu Gln Arg Lys 
            740                 745                 750         


Arg Lys Lys Glu Arg Lys Lys Lys Gln Ile Arg Lys Lys Tyr Gln Leu 
        755                 760                 765             


Gln Lys Lys Glu Lys Glu Ile Leu Arg Lys Lys Arg Tyr Lys Lys Leu 
    770                 775                 780                 


Ile Glu Asn Glu Lys Ile Phe Gln Lys Glu Met Lys Lys Glu Leu Met 
785                 790                 795                 800 


His Lys Arg Asn Asn Lys Ile Lys His Glu Asn Lys His Glu Glu Asn 
                805                 810                 815     


Tyr Tyr Ile Asn Asn Lys Asn Asp His Thr Tyr Gly His Lys Ser Lys 
            820                 825                 830         


Thr Gln Lys His Tyr Lys Lys Tyr His Asp Lys Tyr Glu Asp Lys Tyr 
        835                 840                 845             


His His Lys Tyr His Lys Lys Glu Pro Lys Gln Lys Asn Ile Tyr Asn 
    850                 855                 860                 


His Leu Asn Asn Pro His Asn Pro Ser Tyr Asn Asp Leu Glu Lys Asn 
865                 870                 875                 880 


Gln Ser Leu Thr Ser Asn Thr Asn Ser Ser Gln Glu Tyr Tyr Glu Lys 
                885                 890                 895     


Lys Lys Tyr Glu Asn Thr Leu Ser Ser Ala Glu His Ile Asn Ile Lys 
            900                 905                 910         


Asn Thr His His Lys Ser Lys Leu Asn Thr Phe Asn Asn Lys Asn Thr 
        915                 920                 925             


Tyr Asp Asn Gln Tyr Ile Lys Lys Glu Pro Tyr Asp Lys Asp Asn Ile 
    930                 935                 940                 


Tyr Ser Asp Phe Tyr Ala Ile Lys Asn Asn Asp Gln Gln Ser Ile Leu 
945                 950                 955                 960 


Gln Glu Lys Lys Lys Asn Arg Arg Ser Ile Ser Asn Ile Ser Lys Ile 
                965                 970                 975     


Tyr Lys Asn Asn Asp Thr Ile Gln Leu Ser Asn Lys Asp Ser Lys Thr 
            980                 985                 990         


Ser Arg Lys Asp Leu Leu Pro 
        995                 


<210>  3
<211>  22
<212>  PRT
<213>  Plasmodium falciparum

<400>  3

Arg Gln Asp Asp Met Val Phe Pro Leu Phe Ser His Phe Asn Tyr Lys 
1               5                   10                  15      


Lys Ala Lys Phe Lys Cys 
            20          


<210>  4
<211>  32
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Arg Gln Asp Asp Met Val Phe Pro Leu Phe Ser His Phe Asn Tyr Lys 
1               5                   10                  15      


Lys Ala Lys Phe Lys Cys Asn Lys Lys Glu Gln Glu Glu Asp Ile Val 
            20                  25                  30          


<210>  5
<211>  46
<212>  PRT
<213>  Plasmodium falciparum

<400>  5

Phe Cys Cys Tyr Cys Arg Gln Asp Asp Met Val Phe Pro Leu Phe Ser 
1               5                   10                  15      


His Phe Asn Tyr Lys Lys Ala Lys Phe Lys Cys Asn Lys Lys Glu Gln 
            20                  25                  30          


Glu Glu Asp Ile Val Leu Thr Leu Ser Cys Leu Lys Lys Lys 
        35                  40                  45      


<210>  6
<211>  45
<212>  PRT
<213>  Plasmodium berghei

<400>  6

Phe Cys Cys Tyr Cys Thr Gln Ser Ser Ile Phe Pro Leu Tyr Phe Gln 
1               5                   10                  15      


Leu Lys Tyr Arg Arg Lys Lys Leu Leu Cys Asn Lys Lys Asp Asn Asn 
            20                  25                  30          


Glu Asp Val Ile Leu Thr Phe Ser Cys Leu Lys Lys Lys 
        35                  40                  45  


<210>  7
<211>  45
<212>  PRT
<213>  Plasmodium yoelii

<400>  7

Phe Cys Cys Tyr Cys Thr Gln Ser Ser Ile Phe Pro Leu Tyr Ser Lys 
1               5                   10                  15      


Leu Lys Tyr Arg Arg Lys Lys Leu Leu Cys Asn Lys Lys Asp Asn Asn 
            20                  25                  30          


Glu Asn Val Ile Leu Thr Leu Ser Cys Leu Lys Lys Lys 
        35                  40                  45  


<210>  8
<211>  47
<212>  PRT
<213>  Plasmodium vivax

<400>  8

Phe Cys Cys His Cys Ser Pro His Pro Val Phe Pro Leu Tyr Ser Ser 
1               5                   10                  15      


Leu Lys Tyr Arg Arg Gln Lys Val Leu Cys Arg Arg Arg Val Thr Asp 
            20                  25                  30          


Gly Glu Glu Ala Val Val Leu Thr Leu Lys Cys Leu Lys Lys Ser 
        35                  40                  45          


<210>  9
<211>  46
<212>  PRT
<213>  Plasmodium falciparum

<400>  9

Glu Ser Cys Ile Cys Pro Ser Tyr His Leu Phe Lys Asn Asp Asn Ser 
1               5                   10                  15      


Ile Lys Arg Ala Lys Leu Lys Cys Thr Tyr Phe Asn Met Leu Phe Thr 
            20                  25                  30          


Asp Ser Ala Ile Val Tyr Ser Arg His Cys Ala Ile Met Asp 
        35                  40                  45      


<210>  10
<211>  48
<212>  PRT
<213>  Toxoplasma gondii

<400>  10

Arg Cys Cys Trp Cys Ser Glu Val Leu Ala Phe Thr His Ile Asn Asn 
1               5                   10                  15      


Met Lys Arg Gly Asn Phe Arg Cys Asn Trp Phe Ala Pro Pro Arg Ala 
            20                  25                  30          


Leu Glu Leu Val Thr Glu Thr Leu Tyr Asp Gln Cys Glu Ala Gly Lys 
        35                  40                  45              


<210>  11
<211>  52
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  11

Phe Cys Cys Glu Cys Ser Ser Ser Gln Val Trp Asp Asp Thr Phe Gly 
1               5                   10                  15      


Ser Ser Lys Glu Arg Thr Arg Ala Asn Leu Asp Cys Asp Phe Trp Ser 
            20                  25                  30          


Asp Pro Leu Asp Ile Leu Ile Gly Arg Lys Pro Val Ser Ala His Cys 
        35                  40                  45              


Leu Thr Phe Asp 
    50          


<210>  12
<211>  43
<212>  PRT
<213>  Plasmodium falciparum

<400>  12

Cys Cys Tyr Cys Arg Gln Asp Asp Met Val Phe Pro Leu Phe Ser His 
1               5                   10                  15      


Phe Asn Tyr Lys Lys Ala Lys Phe Lys Cys Asn Lys Lys Glu Gln Glu 
            20                  25                  30          


Glu Asp Ile Val Leu Thr Leu Ser Cys Leu Lys 
        35                  40              


