                         SEQUENCE LISTING

<110>  MAGICMED INDUSTRIES INC.
 
<120>  HALOGENATED PSILOCYBIN DERIVATIVES AND METHODS OF USING

<130>  21806-P62051PC00

<150>  US 63/073,104
<151>  2020-09-01

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  1320
<212>  DNA
<213>  Psilocybe cubensis

<400>  1
atgcaggtga tacccgcgtg caactcggca gcaataagat cactatgtcc tactcccgag       60

tcttttagaa acatgggatg gctctctgtc agcgatgcgg tctacagcga gttcatagga      120

gagttggcta cccgcgcttc caatcgaaat tactccaacg agttcggcct catgcaacct      180

atccaggaat tcaaggcttt cattgaaagc gacccggtgg tgcaccaaga atttattgac      240

atgttcgagg gcattcagga ctctccaagg aattatcagg aactatgtaa tatgttcaac      300

gatatctttc gcaaagctcc cgtctacgga gaccttggcc ctcccgttta tatgattatg      360

gccaaattaa tgaacacccg agcgggcttc tctgcattca cgagacaaag gttgaacctt      420

cacttcaaaa aacttttcga tacctgggga ttgttcctgt cttcgaaaga ttctcgaaat      480

gttcttgtgg ccgaccagtt cgacgacaga cattgcggct ggttgaacga gcgggccttg      540

tctgctatgg ttaaacatta caatggacgc gcatttgatg aagtcttcct ctgcgataaa      600

aatgccccat actacggctt caactcttac gacgacttct ttaatcgcag atttcgaaac      660

cgagatatcg accgacctgt agtcggtgga gttaacaaca ccaccctcat ttctgctgct      720

tgcgaatcac tttcctacaa cgtctcttat gacgtccagt ctctcgacac tttagttttc      780

aaaggagaga cttattcgct taagcatttg ctgaataatg accctttcac cccacaattc      840

gagcatggga gtattctaca aggattcttg aacgtcaccg cttaccaccg atggcacgca      900

cccgtcaatg ggacaatcgt caaaatcatc aacgttccag gtacctactt tgcgcaagcc      960

ccgagcacga ttggcgaccc tatcccggat aacgattacg acccacctcc ttaccttaag     1020

tctcttgtct acttctctaa tattgccgca aggcaaatta tgtttattga agccgacaac     1080

aaggaaattg gcctcatttt ccttgtgttc atcggcatga ccgaaatctc gacatgtgaa     1140

gccacggtgt ccgaaggtca acacgtcaat cgtggcgatg acttgggaat gttccatttc     1200

ggtggttctt cgttcgcgct tggtctgagg aaggattgca gggcagagat cgttgaaaag     1260

ttcaccgaac ccggaacagt gatcagaatc aacgaagtcg tcgctgctct aaaggcttag     1320


<210>  2
<211>  439
<212>  PRT
<213>  Psilocybe cubensis

<400>  2

Met Gln Val Ile Pro Ala Cys Asn Ser Ala Ala Ile Arg Ser Leu Cys 
1               5                   10                  15      


Pro Thr Pro Glu Ser Phe Arg Asn Met Gly Trp Leu Ser Val Ser Asp 
            20                  25                  30          


Ala Val Tyr Ser Glu Phe Ile Gly Glu Leu Ala Thr Arg Ala Ser Asn 
        35                  40                  45              


Arg Asn Tyr Ser Asn Glu Phe Gly Leu Met Gln Pro Ile Gln Glu Phe 
    50                  55                  60                  


Lys Ala Phe Ile Glu Ser Asp Pro Val Val His Gln Glu Phe Ile Asp 
65                  70                  75                  80  


Met Phe Glu Gly Ile Gln Asp Ser Pro Arg Asn Tyr Gln Glu Leu Cys 
                85                  90                  95      


Asn Met Phe Asn Asp Ile Phe Arg Lys Ala Pro Val Tyr Gly Asp Leu 
            100                 105                 110         


Gly Pro Pro Val Tyr Met Ile Met Ala Lys Leu Met Asn Thr Arg Ala 
        115                 120                 125             


Gly Phe Ser Ala Phe Thr Arg Gln Arg Leu Asn Leu His Phe Lys Lys 
    130                 135                 140                 


Leu Phe Asp Thr Trp Gly Leu Phe Leu Ser Ser Lys Asp Ser Arg Asn 
145                 150                 155                 160 


Val Leu Val Ala Asp Gln Phe Asp Asp Arg His Cys Gly Trp Leu Asn 
                165                 170                 175     


Glu Arg Ala Leu Ser Ala Met Val Lys His Tyr Asn Gly Arg Ala Phe 
            180                 185                 190         


Asp Glu Val Phe Leu Cys Asp Lys Asn Ala Pro Tyr Tyr Gly Phe Asn 
        195                 200                 205             


Ser Tyr Asp Asp Phe Phe Asn Arg Arg Phe Arg Asn Arg Asp Ile Asp 
    210                 215                 220                 


Arg Pro Val Val Gly Gly Val Asn Asn Thr Thr Leu Ile Ser Ala Ala 
225                 230                 235                 240 


Cys Glu Ser Leu Ser Tyr Asn Val Ser Tyr Asp Val Gln Ser Leu Asp 
                245                 250                 255     


Thr Leu Val Phe Lys Gly Glu Thr Tyr Ser Leu Lys His Leu Leu Asn 
            260                 265                 270         


Asn Asp Pro Phe Thr Pro Gln Phe Glu His Gly Ser Ile Leu Gln Gly 
        275                 280                 285             


Phe Leu Asn Val Thr Ala Tyr His Arg Trp His Ala Pro Val Asn Gly 
    290                 295                 300                 


Thr Ile Val Lys Ile Ile Asn Val Pro Gly Thr Tyr Phe Ala Gln Ala 
305                 310                 315                 320 


Pro Ser Thr Ile Gly Asp Pro Ile Pro Asp Asn Asp Tyr Asp Pro Pro 
                325                 330                 335     


Pro Tyr Leu Lys Ser Leu Val Tyr Phe Ser Asn Ile Ala Ala Arg Gln 
            340                 345                 350         


Ile Met Phe Ile Glu Ala Asp Asn Lys Glu Ile Gly Leu Ile Phe Leu 
        355                 360                 365             


Val Phe Ile Gly Met Thr Glu Ile Ser Thr Cys Glu Ala Thr Val Ser 
    370                 375                 380                 


Glu Gly Gln His Val Asn Arg Gly Asp Asp Leu Gly Met Phe His Phe 
385                 390                 395                 400 


Gly Gly Ser Ser Phe Ala Leu Gly Leu Arg Lys Asp Cys Arg Ala Glu 
                405                 410                 415     


Ile Val Glu Lys Phe Thr Glu Pro Gly Thr Val Ile Arg Ile Asn Glu 
            420                 425                 430         


Val Val Ala Ala Leu Lys Ala 
        435                 


<210>  3
<211>  2155
<212>  DNA
<213>  Psilocybe cubensis

<400>  3
atgatcgctg tactattctc cttcgtcatt gcaggatgca tatactacat cgtttctcgt       60

agagtgaggc ggtcgcgctt gccaccaggg ccgcctggca ttcctattcc cttcattggg      120

aacatgtttg atatgcctga agaatctcca tggttaacat ttctacaatg gggacgggat      180

tacagtctgt cttgccgcgt tgacttctaa tatatgaaca gctaatatat tgtcagacac      240

cgatattctc tacgtggatg ctggagggac agaaatggtt attcttaaca cgttggagac      300

cattaccgat ctattagaaa agcgagggtc catttattct ggccggtgag ctgatgttga      360

gttttttgca attgaatttg tggtcacacg tttccagact tgagagtaca atggtcaacg      420

aacttatggg gtgggagttt gacttagggt tcatcacata cggcgacagg tggcgcgaag      480

aaaggcgcat gttcgccaag gagttcagtg agaagggcat caagcaattt cgccatgctc      540

aagtgaaagc tgcccatcag cttgtccaac agcttaccaa aacgccagac cgctgggcac      600

aacatattcg ccagtaagta ctacttgagg aaaatagcgt acgcttcgct gaccggtccg      660

tacatcaaag tcagatagcg gcaatgtcac tggatattgg ttatggaatt gatcttgcag      720

aagacgaccc ttggctggaa gcgacccatt tggctaatga aggcctcgcc atagcatcag      780

tgccgggcaa attttgggtc gattcgttcc cttctcgtga gcatccttct tctatgtagg      840

aagggaagga gtctaacaag tgttagtaaa ataccttcct gcttggttcc caggtgctgt      900

cttcaagcgc aaagcgaagg tctggcgaga agccgccgac catatggttg acatgcctta      960

tgaaactatg aggaaattag cagttagtca aatgcgttct ccccgtattt tttcaatact     1020

ctaacttcag ctcacagcct caaggattga ctcgtccgtc gtatgcttca gctcgtctgc     1080

aagccatgga tctcaacggt gaccttgagc atcaagaaca cgtaatcaag aacacagccg     1140

cagaggttaa tgtcggtaag tcaaaagcgt ccgtcggcaa ttcaaaattc aggcgctaaa     1200

gtgggtcttc tcaccaaggt ggaggcgata ctgtaaggat ttctcaatcg ttagagtata     1260

agtgttctaa tgcagtacat actccaccaa ccagactgtc tctgctatgt ctgcgttcat     1320

cttggccatg gtgaagtacc ctgaggtcca gcgaaaggtt caagcggagc ttgatgctct     1380

gaccaataac ggccaaattc ctgactatga cgaagaagat gactccttgc catacctcac     1440

cgcatgtatc aaggagcttt tccggtggaa tcaaatcgca cccctcgcta taccgcacaa     1500

attaatgaag gacgacgtgt accgcgggta tctgattccc aagaacactc tagtcttcgc     1560

aaacacctgg tgaggctgtc cattcattcc tagtacatcc gttgccccac taatagcatc     1620

ttgataacag ggcagtatta aacgatccag aagtctatcc agatccctct gtgttccgcc     1680

cagaaagata tcttggtcct gacgggaagc ctgataacac tgtacgcgac ccacgtaaag     1740

cggcatttgg ctatggacga cgaaattggt aagtgcgctt tcagaacccc cccttccgtt     1800

gactagtgcc atgcgcgcat acaatatcgc tattgatctg atataacttc cctgcggcat     1860

ttattttggc attcctttag tcccggaatt catctagcgc agtcgacggt ttggattgca     1920

ggggcaaccc tcttatcagc gttcaatatc gagcgacctg tcgatcagaa tgggaagccc     1980

attgacatac cggctgattt tactacagga ttcttcaggt agctaatttc cgtctttgtg     2040

tgcataatac ccctaacgac gcacgtttac ctttttgtaa agacacccag tgcctttcca     2100

gtgcaggttt gttcctcgaa cagagcaagt ctcacagtcg gtatccggac cctga          2155


<210>  4
<211>  508
<212>  PRT
<213>  Psilocybe cubensis

<400>  4

Met Ile Ala Val Leu Phe Ser Phe Val Ile Ala Gly Cys Ile Tyr Tyr 
1               5                   10                  15      


Ile Val Ser Arg Arg Val Arg Arg Ser Arg Leu Pro Pro Gly Pro Pro 
            20                  25                  30          


Gly Ile Pro Ile Pro Phe Ile Gly Asn Met Phe Asp Met Pro Glu Glu 
        35                  40                  45              


Ser Pro Trp Leu Thr Phe Leu Gln Trp Gly Arg Asp Tyr Asn Thr Asp 
    50                  55                  60                  


Ile Leu Tyr Val Asp Ala Gly Gly Thr Glu Met Val Ile Leu Asn Thr 
65                  70                  75                  80  


Leu Glu Thr Ile Thr Asp Leu Leu Glu Lys Arg Gly Ser Ile Tyr Ser 
                85                  90                  95      


Gly Arg Leu Glu Ser Thr Met Val Asn Glu Leu Met Gly Trp Glu Phe 
            100                 105                 110         


Asp Leu Gly Phe Ile Thr Tyr Gly Asp Arg Trp Arg Glu Glu Arg Arg 
        115                 120                 125             


Met Phe Ala Lys Glu Phe Ser Glu Lys Gly Ile Lys Gln Phe Arg His 
    130                 135                 140                 


Ala Gln Val Lys Ala Ala His Gln Leu Val Gln Gln Leu Thr Lys Thr 
145                 150                 155                 160 


Pro Asp Arg Trp Ala Gln His Ile Arg His Gln Ile Ala Ala Met Ser 
                165                 170                 175     


Leu Asp Ile Gly Tyr Gly Ile Asp Leu Ala Glu Asp Asp Pro Trp Leu 
            180                 185                 190         


Glu Ala Thr His Leu Ala Asn Glu Gly Leu Ala Ile Ala Ser Val Pro 
        195                 200                 205             


Gly Lys Phe Trp Val Asp Ser Phe Pro Ser Leu Lys Tyr Leu Pro Ala 
    210                 215                 220                 


Trp Phe Pro Gly Ala Val Phe Lys Arg Lys Ala Lys Val Trp Arg Glu 
225                 230                 235                 240 


Ala Ala Asp His Met Val Asp Met Pro Tyr Glu Thr Met Arg Lys Leu 
                245                 250                 255     


Ala Pro Gln Gly Leu Thr Arg Pro Ser Tyr Ala Ser Ala Arg Leu Gln 
            260                 265                 270         


Ala Met Asp Leu Asn Gly Asp Leu Glu His Gln Glu His Val Ile Lys 
        275                 280                 285             


Asn Thr Ala Ala Glu Val Asn Val Gly Gly Gly Asp Thr Thr Val Ser 
    290                 295                 300                 


Ala Met Ser Ala Phe Ile Leu Ala Met Val Lys Tyr Pro Glu Val Gln 
305                 310                 315                 320 


Arg Lys Val Gln Ala Glu Leu Asp Ala Leu Thr Asn Asn Gly Gln Ile 
                325                 330                 335     


Pro Asp Tyr Asp Glu Glu Asp Asp Ser Leu Pro Tyr Leu Thr Ala Cys 
            340                 345                 350         


Ile Lys Glu Leu Phe Arg Trp Asn Gln Ile Ala Pro Leu Ala Ile Pro 
        355                 360                 365             


His Lys Leu Met Lys Asp Asp Val Tyr Arg Gly Tyr Leu Ile Pro Lys 
    370                 375                 380                 


Asn Thr Leu Val Phe Ala Asn Thr Trp Ala Val Leu Asn Asp Pro Glu 
385                 390                 395                 400 


Val Tyr Pro Asp Pro Ser Val Phe Arg Pro Glu Arg Tyr Leu Gly Pro 
                405                 410                 415     


Asp Gly Lys Pro Asp Asn Thr Val Arg Asp Pro Arg Lys Ala Ala Phe 
            420                 425                 430         


Gly Tyr Gly Arg Arg Asn Cys Pro Gly Ile His Leu Ala Gln Ser Thr 
        435                 440                 445             


Val Trp Ile Ala Gly Ala Thr Leu Leu Ser Ala Phe Asn Ile Glu Arg 
    450                 455                 460                 


Pro Val Asp Gln Asn Gly Lys Pro Ile Asp Ile Pro Ala Asp Phe Thr 
465                 470                 475                 480 


Thr Gly Phe Phe Arg His Pro Val Pro Phe Gln Cys Arg Phe Val Pro 
                485                 490                 495     


Arg Thr Glu Gln Val Ser Gln Ser Val Ser Gly Pro 
            500                 505             


<210>  5
<211>  1089
<212>  DNA
<213>  Psilocybe cubensis

<400>  5
atggcgttcg atctcaagac tgaagacggc ctcatcacat atctcactaa acatctttct       60

ttggacgtcg acacgagcgg agtgaagcgc cttagcggag gctttgtcaa tgtaacctgg      120

cgcattaagc tcaatgctcc ttatcaaggt catacgagca tcatcctgaa gcatgctcag      180

ccgcacatgt ctacggatga ggattttaag ataggtgtag aacgttcggt ttacgaatac      240

caggctatca agctcatgat ggccaatcgg gaggttctgg gaggcgtgga tggcatagtt      300

tctgtgccag aaggcctgaa ctacgactta gagaataatg cattgatcat gcaagatgtc      360

gggaagatga agaccctttt agattatgtc accgccaaac cgccacttgc gacggatata      420

gcccgccttg ttgggacaga aattgggggg ttcgttgcca gactccataa cataggccgc      480

gagaggcgag acgatcctga gttcaaattc ttctctggaa atattgtcgg aaggacgact      540

tcagaccagc tgtatcaaac catcataccc aacgcagcga aatatggcgt cgatgacccc      600

ttgctgccta ctgtggttaa ggaccttgtg gacgatgtca tgcacagcga agagaccctt      660

gtcatggcgg acctgtggag tggaaatatt cttctccagt tggaggaggg aaacccatcg      720

aagctgcaga agatatatat cctggattgg gaactttgca agtacggccc agcgtcgttg      780

gacctgggct atttcttggg tgactgctat ttgatatccc gctttcaaga cgagcaggtc      840

ggtacgacga tgcggcaagc ctacttgcaa agctatgcgc gtacgagcaa gcattcgatc      900

aactacgcca aagtcactgc aggtattgct gctcatattg tgatgtggac cgactttatg      960

cagtggggga gcgaggaaga aaggataaat tttgtgaaaa agggggtagc tgcctttcac     1020

gacgccaggg gcaacaacga caatggggaa attacgtcta ccttactgaa ggaatcatcc     1080

actgcgtaa                                                             1089


<210>  6
<211>  309
<212>  PRT
<213>  Psilocybe cubensis

<400>  6

Met His Ile Arg Asn Pro Tyr Arg Thr Pro Ile Asp Tyr Gln Ala Leu 
1               5                   10                  15      


Ser Glu Ala Phe Pro Pro Leu Lys Pro Phe Val Ser Val Asn Ala Asp 
            20                  25                  30          


Gly Thr Ser Ser Val Asp Leu Thr Ile Pro Glu Ala Gln Arg Ala Phe 
        35                  40                  45              


Thr Ala Ala Leu Leu His Arg Asp Phe Gly Leu Thr Met Thr Ile Pro 
    50                  55                  60                  


Glu Asp Arg Leu Cys Pro Thr Val Pro Asn Arg Leu Asn Tyr Val Leu 
65                  70                  75                  80  


Trp Ile Glu Asp Ile Phe Asn Tyr Thr Asn Lys Thr Leu Gly Leu Ser 
                85                  90                  95      


Asp Asp Arg Pro Ile Lys Gly Val Asp Ile Gly Thr Gly Ala Ser Ala 
            100                 105                 110         


Ile Tyr Pro Met Leu Ala Cys Ala Arg Phe Lys Ala Trp Ser Met Val 
        115                 120                 125             


Gly Thr Glu Val Glu Arg Lys Cys Ile Asp Thr Ala Arg Leu Asn Val 
    130                 135                 140                 


Val Ala Asn Asn Leu Gln Asp Arg Leu Ser Ile Leu Glu Thr Ser Ile 
145                 150                 155                 160 


Asp Gly Pro Ile Leu Val Pro Ile Phe Glu Ala Thr Glu Glu Tyr Glu 
                165                 170                 175     


Tyr Glu Phe Thr Met Cys Asn Pro Pro Phe Tyr Asp Gly Ala Ala Asp 
            180                 185                 190         


Met Gln Thr Ser Asp Ala Ala Lys Gly Phe Gly Phe Gly Val Gly Ala 
        195                 200                 205             


Pro His Ser Gly Thr Val Ile Glu Met Ser Thr Glu Gly Gly Glu Ser 
    210                 215                 220                 


Ala Phe Val Ala Gln Met Val Arg Glu Ser Leu Lys Leu Arg Thr Arg 
225                 230                 235                 240 


Cys Arg Trp Tyr Thr Ser Asn Leu Gly Lys Leu Lys Ser Leu Lys Glu 
                245                 250                 255     


Ile Val Gly Leu Leu Lys Glu Leu Glu Ile Ser Asn Tyr Ala Ile Asn 
            260                 265                 270         


Glu Tyr Val Gln Gly Ser Thr Arg Arg Tyr Ala Val Ala Trp Ser Phe 
        275                 280                 285             


Thr Asp Ile Gln Leu Pro Glu Glu Leu Ser Arg Pro Ser Asn Pro Glu 
    290                 295                 300                 


Leu Ser Ser Leu Phe 
305                 


<210>  7
<211>  930
<212>  DNA
<213>  Psilocybe cubensis

<400>  7
atgcatatca gaaatcctta ccgtacacca attgactatc aagcactttc agaggccttc       60

cctcccctca agccatttgt gtctgtcaat gcagatggta ccagttctgt tgacctcact      120

atcccagaag cccagagggc gttcacggcc gctcttcttc atcgtgactt cgggctcacc      180

atgaccatac cagaagaccg tctgtgccca acagtcccca ataggttgaa ctacgttctg      240

tggattgaag atattttcaa ctacacgaac aaaaccctcg gcctgtcgga tgaccgtcct      300

attaaaggcg ttgatattgg tacaggagcc tccgcaattt atcctatgct tgcctgtgct      360

cggttcaagg catggtctat ggttggaaca gaggtcgaga ggaagtgcat tgacacggcc      420

cgcctcaatg tcgtcgcgaa caatctccaa gaccgtctct cgatattaga gacatccatt      480

gatggtccta ttctcgtccc cattttcgag gcgactgaag aatacgaata cgagtttact      540

atgtgtaacc ctccattcta cgacggtgct gccgatatgc agacttcgga tgctgccaaa      600

ggatttggat ttggcgtggg cgctccccat tctggaacag tcatcgaaat gtcgactgag      660

ggaggtgaat cggctttcgt cgctcagatg gtccgtgaga gcttgaagct tcgaacacga      720

tgcagatggt acacgagtaa cttgggaaag ctgaaatcct tgaaagaaat agtggggctg      780

ctgaaagaac ttgagataag caactatgcc attaacgaat acgttcaggg gtccacacgt      840

cgttatgccg ttgcgtggtc tttcactgat attcaactgc ctgaggagct ttctcgtccc      900

tctaaccccg agctcagctc tcttttctag                                       930


<210>  8
<211>  309
<212>  PRT
<213>  Psilocybe cubensis

<400>  8

Met His Ile Arg Asn Pro Tyr Arg Thr Pro Ile Asp Tyr Gln Ala Leu 
1               5                   10                  15      


Ser Glu Ala Phe Pro Pro Leu Lys Pro Phe Val Ser Val Asn Ala Asp 
            20                  25                  30          


Gly Thr Ser Ser Val Asp Leu Thr Ile Pro Glu Ala Gln Arg Ala Phe 
        35                  40                  45              


Thr Ala Ala Leu Leu His Arg Asp Phe Gly Leu Thr Met Thr Ile Pro 
    50                  55                  60                  


Glu Asp Arg Leu Cys Pro Thr Val Pro Asn Arg Leu Asn Tyr Val Leu 
65                  70                  75                  80  


Trp Ile Glu Asp Ile Phe Asn Tyr Thr Asn Lys Thr Leu Gly Leu Ser 
                85                  90                  95      


Asp Asp Arg Pro Ile Lys Gly Val Asp Ile Gly Thr Gly Ala Ser Ala 
            100                 105                 110         


Ile Tyr Pro Met Leu Ala Cys Ala Arg Phe Lys Ala Trp Ser Met Val 
        115                 120                 125             


Gly Thr Glu Val Glu Arg Lys Cys Ile Asp Thr Ala Arg Leu Asn Val 
    130                 135                 140                 


Val Ala Asn Asn Leu Gln Asp Arg Leu Ser Ile Leu Glu Thr Ser Ile 
145                 150                 155                 160 


Asp Gly Pro Ile Leu Val Pro Ile Phe Glu Ala Thr Glu Glu Tyr Glu 
                165                 170                 175     


Tyr Glu Phe Thr Met Cys Asn Pro Pro Phe Tyr Asp Gly Ala Ala Asp 
            180                 185                 190         


Met Gln Thr Ser Asp Ala Ala Lys Gly Phe Gly Phe Gly Val Gly Ala 
        195                 200                 205             


Pro His Ser Gly Thr Val Ile Glu Met Ser Thr Glu Gly Gly Glu Ser 
    210                 215                 220                 


Ala Phe Val Ala Gln Met Val Arg Glu Ser Leu Lys Leu Arg Thr Arg 
225                 230                 235                 240 


Cys Arg Trp Tyr Thr Ser Asn Leu Gly Lys Leu Lys Ser Leu Lys Glu 
                245                 250                 255     


Ile Val Gly Leu Leu Lys Glu Leu Glu Ile Ser Asn Tyr Ala Ile Asn 
            260                 265                 270         


Glu Tyr Val Gln Gly Ser Thr Arg Arg Tyr Ala Val Ala Trp Ser Phe 
        275                 280                 285             


Thr Asp Ile Gln Leu Pro Glu Glu Leu Ser Arg Pro Ser Asn Pro Glu 
    290                 295                 300                 


Leu Ser Ser Leu Phe 
305                 


<210>  9
<211>  3042
<212>  DNA
<213>  Psilocybe cubensis

<400>  9
atgccttcca gtcaccctca cattactcat cgctatcggg ttccttcgag tgacgaccat       60

gaacgtatat ctgctctgtt cttgggtccc aaagcagaaa atgccgcatt tctccagcaa      120

tggttgacca cggtcgtcgc acagcaaaag gctgcccgcg atgcatactt cccggatgac      180

aatgctttta ttactacaga catgcaaact tcccccgcct ttgctcagac tactaaagta      240

atcgcctcca atctcaccga attattgact gcactcggtg aaaggtcgat tcctttcttc      300

tcacctcggt acagcggcca tatgtctgtg gaccaaagtc tacctgccat tctcggattc      360

ttatcgacca cattttataa tcctaacaat gttgccttcg aggctagtcc attcacgacc      420

ctcatcgagg aagaagttgg cttgcaactc tctgaaatgc tgggttataa tcggctaaat      480

aacaccgaga aacctctcgc ctggggacat attgcatcag gtggaactgt tgcaaacttg      540

gaagcgatgt gggcggcgcg aaacctcaag ttttaccctc tctcactccg tgatgcttca      600

gccgaaggcg cagagatgga attcattcgt gacacattct ccgtcaaaac ctgtgttggt      660

gacaaaaaat tattaaagga ttgcagccca tgggaactcc tcaatttgca tgtttctact      720

atcttagaca tgcccgaccg tctgcacgac gagtacaata tttcacctca gttcctcgaa      780

aaggttatgc gaaagtatat catccagtct accaacaaag acacgttgat gcagcgttgg      840

ggacttaccc aacaacctgt cgttttatcc ccgagcacaa accattattc ctggccaaag      900

gctgcagctg tgctcggtat tggctcagac aaccttcgca acgtcccagt agacatccaa      960

gcccacatgg acataaacga actcgatcgt atgttaaaaa tttgcttgga cgaggagacg     1020

ccagtatatc aagtagttgc tgttatcggt accaccgaag agggcggtgt cgatcgcatt     1080

acggagatcc tgaagctgcg ccaaaagtat gaagctttgg ggctgtcttt tgccatccat     1140

gcagatgctg cttggggagg ctattttgca accatgctac ccaaagatac attgggtcga     1200

aaccggacta ggcttcccaa agaggacact acctcgggct ttgtccctca cgtcggtctg     1260

cgcgaggaga gcgcgttaca actcagccat ataaagtatg ccgattctat tactatcgac     1320

ccgcacaagg caggctatgt tccttacccc gctggggcac tctgttatcg cgacggaaga     1380

atgaggtacc tgcttacatg gtccgcgccc taccttgccc aaggcaacga gggccaaagt     1440

atcggaatat acgggatcga aggaagcaaa cctggtgcag cagcatccgc ggtattcatg     1500

gcgcacgaaa ccattggcct gactccttct ggatacggga accttcttgg ccaggcaatg     1560

tttacatgtc gccgatacgc tgctcactgg tctgcaatgt caacggatac taccagtttc     1620

actgtcaccc cgttcaatcc tatccctgct gacatcgacc ccaacgctga ccccgcaaag     1680

gtcgaagagc aaaaacagtt catcagagat cgtatcttgt tcaaatcgaa cgaggaaata     1740

tacaacgatt ctgaggctat ggaactcttg caccaacttg ggtccgatct caatatcaac     1800

gttttcgcat gcaacttccg cgaccgcgat aataatctca acaccgacgt cgaggaagcc     1860

aactggctca ataaccgtat tttccaacgc ttttctgtta caagtgctga ggagaaccca     1920

ttggaaacgc cattcttcct cagctcaact acattgaaac aatccgaata cggcgtctgc     1980

gcaaccgaag taaagagacg catgggactt gttggtgacc aggatgttat agtcctgagg     2040

aacgtcgtta tgtctccatt tactacaacg aacgactttg tgggaactct ggcaaacacc     2100

ttccaaaaga tcgttgagga ggaggtcgag tatgcacgga tccgcaacga tatgaaacct     2160

agcattcaca ccttccttct tcatggttca ggagagcaat actatcttgt ccacacccca     2220

acgatccata tggccagcgg ccgtcgccaa atcatccttt cagtaaatgt tgaaggccaa     2280

gttcggcagg cgatacatgc ccatgaaaga gttgaagcag tgattgtaca taacactgtg     2340

cccctccgcc ttgacgaaat cgttgacgga ggatcatttg acggcatact caccatcgga     2400

aagaggaaaa ctagtttcaa agtgaagatt tcaaacatta aagtagtcaa gaagcgctct     2460

ctgatgactg aggacctgga atctgcgtac ccatcgttga tgccattcta tttctacggg     2520

actcaaggac acgctcatct cgaccatgtc attactgtcg ttcctaacat ccatctgagt     2580

gctggcgaaa tacagtacaa attcgacgac gaggtgtcaa gcgaggacct cgccaagggc     2640

ctcattgttg ttgctgagaa cgtacacgag gcatccatgc agcccttccc gctcatgaaa     2700

gatttcaaga tcaccaacca attcttcttc agctccgggc aaatactccg cgtcaaagtg     2760

tacagagatc catacccggc atcgacaatg gatcccatcc ctctccacga catcaagaac     2820

cagcccgtcg tgacacaagg caccatcacg ctcgtcggaa atatttacgt cgattctgat     2880

gcgctcaacg tcgcttccga gcctactgcc gacgaagacg cggcgcatgt tcctcacgct     2940

cgcaacatgt acggcgagat gaccgctgga acgatcaaag gctggcaaaa cgctgttcgt     3000

catttccaca acaaattgga gactgttgct ccgacgaagt ag                        3042


<210>  10
<211>  1013
<212>  PRT
<213>  Psilocybe cubensis

<400>  10

Met Pro Ser Ser His Pro His Ile Thr His Arg Tyr Arg Val Pro Ser 
1               5                   10                  15      


Ser Asp Asp His Glu Arg Ile Ser Ala Leu Phe Leu Gly Pro Lys Ala 
            20                  25                  30          


Glu Asn Ala Ala Phe Leu Gln Gln Trp Leu Thr Thr Val Val Ala Gln 
        35                  40                  45              


Gln Lys Ala Ala Arg Asp Ala Tyr Phe Pro Asp Asp Asn Ala Phe Ile 
    50                  55                  60                  


Thr Thr Asp Met Gln Thr Ser Pro Ala Phe Ala Gln Thr Thr Lys Val 
65                  70                  75                  80  


Ile Ala Ser Asn Leu Thr Glu Leu Leu Thr Ala Leu Gly Glu Arg Ser 
                85                  90                  95      


Ile Pro Phe Phe Ser Pro Arg Tyr Ser Gly His Met Ser Val Asp Gln 
            100                 105                 110         


Ser Leu Pro Ala Ile Leu Gly Phe Leu Ser Thr Thr Phe Tyr Asn Pro 
        115                 120                 125             


Asn Asn Val Ala Phe Glu Ala Ser Pro Phe Thr Thr Leu Ile Glu Glu 
    130                 135                 140                 


Glu Val Gly Leu Gln Leu Ser Glu Met Leu Gly Tyr Asn Arg Leu Asn 
145                 150                 155                 160 


Asn Thr Glu Lys Pro Leu Ala Trp Gly His Ile Ala Ser Gly Gly Thr 
                165                 170                 175     


Val Ala Asn Leu Glu Ala Met Trp Ala Ala Arg Asn Leu Lys Phe Tyr 
            180                 185                 190         


Pro Leu Ser Leu Arg Asp Ala Ser Ala Glu Gly Ala Glu Met Glu Phe 
        195                 200                 205             


Ile Arg Asp Thr Phe Ser Val Lys Thr Cys Val Gly Asp Lys Lys Leu 
    210                 215                 220                 


Leu Lys Asp Cys Ser Pro Trp Glu Leu Leu Asn Leu His Val Ser Thr 
225                 230                 235                 240 


Ile Leu Asp Met Pro Asp Arg Leu His Asp Glu Tyr Asn Ile Ser Pro 
                245                 250                 255     


Gln Phe Leu Glu Lys Val Met Arg Lys Tyr Ile Ile Gln Ser Thr Asn 
            260                 265                 270         


Lys Asp Thr Leu Met Gln Arg Trp Gly Leu Thr Gln Gln Pro Val Val 
        275                 280                 285             


Leu Ser Pro Ser Thr Asn His Tyr Ser Trp Pro Lys Ala Ala Ala Val 
    290                 295                 300                 


Leu Gly Ile Gly Ser Asp Asn Leu Arg Asn Val Pro Val Asp Ile Gln 
305                 310                 315                 320 


Ala His Met Asp Ile Asn Glu Leu Asp Arg Met Leu Lys Ile Cys Leu 
                325                 330                 335     


Asp Glu Glu Thr Pro Val Tyr Gln Val Val Ala Val Ile Gly Thr Thr 
            340                 345                 350         


Glu Glu Gly Gly Val Asp Arg Ile Thr Glu Ile Leu Lys Leu Arg Gln 
        355                 360                 365             


Lys Tyr Glu Ala Leu Gly Leu Ser Phe Ala Ile His Ala Asp Ala Ala 
    370                 375                 380                 


Trp Gly Gly Tyr Phe Ala Thr Met Leu Pro Lys Asp Thr Leu Gly Arg 
385                 390                 395                 400 


Asn Arg Thr Arg Leu Pro Lys Glu Asp Thr Thr Ser Gly Phe Val Pro 
                405                 410                 415     


His Val Gly Leu Arg Glu Glu Ser Ala Leu Gln Leu Ser His Ile Lys 
            420                 425                 430         


Tyr Ala Asp Ser Ile Thr Ile Asp Pro His Lys Ala Gly Tyr Val Pro 
        435                 440                 445             


Tyr Pro Ala Gly Ala Leu Cys Tyr Arg Asp Gly Arg Met Arg Tyr Leu 
    450                 455                 460                 


Leu Thr Trp Ser Ala Pro Tyr Leu Ala Gln Gly Asn Glu Gly Gln Ser 
465                 470                 475                 480 


Ile Gly Ile Tyr Gly Ile Glu Gly Ser Lys Pro Gly Ala Ala Ala Ser 
                485                 490                 495     


Ala Val Phe Met Ala His Glu Thr Ile Gly Leu Thr Pro Ser Gly Tyr 
            500                 505                 510         


Gly Asn Leu Leu Gly Gln Ala Met Phe Thr Cys Arg Arg Tyr Ala Ala 
        515                 520                 525             


His Trp Ser Ala Met Ser Thr Asp Thr Thr Ser Phe Thr Val Thr Pro 
    530                 535                 540                 


Phe Asn Pro Ile Pro Ala Asp Ile Asp Pro Asn Ala Asp Pro Ala Lys 
545                 550                 555                 560 


Val Glu Glu Gln Lys Gln Phe Ile Arg Asp Arg Ile Leu Phe Lys Ser 
                565                 570                 575     


Asn Glu Glu Ile Tyr Asn Asp Ser Glu Ala Met Glu Leu Leu His Gln 
            580                 585                 590         


Leu Gly Ser Asp Leu Asn Ile Asn Val Phe Ala Cys Asn Phe Arg Asp 
        595                 600                 605             


Arg Asp Asn Asn Leu Asn Thr Asp Val Glu Glu Ala Asn Trp Leu Asn 
    610                 615                 620                 


Asn Arg Ile Phe Gln Arg Phe Ser Val Thr Ser Ala Glu Glu Asn Pro 
625                 630                 635                 640 


Leu Glu Thr Pro Phe Phe Leu Ser Ser Thr Thr Leu Lys Gln Ser Glu 
                645                 650                 655     


Tyr Gly Val Cys Ala Thr Glu Val Lys Arg Arg Met Gly Leu Val Gly 
            660                 665                 670         


Asp Gln Asp Val Ile Val Leu Arg Asn Val Val Met Ser Pro Phe Thr 
        675                 680                 685             


Thr Thr Asn Asp Phe Val Gly Thr Leu Ala Asn Thr Phe Gln Lys Ile 
    690                 695                 700                 


Val Glu Glu Glu Val Glu Tyr Ala Arg Ile Arg Asn Asp Met Lys Pro 
705                 710                 715                 720 


Ser Ile His Thr Phe Leu Leu His Gly Ser Gly Glu Gln Tyr Tyr Leu 
                725                 730                 735     


Val His Thr Pro Thr Ile His Met Ala Ser Gly Arg Arg Gln Ile Ile 
            740                 745                 750         


Leu Ser Val Asn Val Glu Gly Gln Val Arg Gln Ala Ile His Ala His 
        755                 760                 765             


Glu Arg Val Glu Ala Val Ile Val His Asn Thr Val Pro Leu Arg Leu 
    770                 775                 780                 


Asp Glu Ile Val Asp Gly Gly Ser Phe Asp Gly Ile Leu Thr Ile Gly 
785                 790                 795                 800 


Lys Arg Lys Thr Ser Phe Lys Val Lys Ile Ser Asn Ile Lys Val Val 
                805                 810                 815     


Lys Lys Arg Ser Leu Met Thr Glu Asp Leu Glu Ser Ala Tyr Pro Ser 
            820                 825                 830         


Leu Met Pro Phe Tyr Phe Tyr Gly Thr Gln Gly His Ala His Leu Asp 
        835                 840                 845             


His Val Ile Thr Val Val Pro Asn Ile His Leu Ser Ala Gly Glu Ile 
    850                 855                 860                 


Gln Tyr Lys Phe Asp Asp Glu Val Ser Ser Glu Asp Leu Ala Lys Gly 
865                 870                 875                 880 


Leu Ile Val Val Ala Glu Asn Val His Glu Ala Ser Met Gln Pro Phe 
                885                 890                 895     


Pro Leu Met Lys Asp Phe Lys Ile Thr Asn Gln Phe Phe Phe Ser Ser 
            900                 905                 910         


Gly Gln Ile Leu Arg Val Lys Val Tyr Arg Asp Pro Tyr Pro Ala Ser 
        915                 920                 925             


Thr Met Asp Pro Ile Pro Leu His Asp Ile Lys Asn Gln Pro Val Val 
    930                 935                 940                 


Thr Gln Gly Thr Ile Thr Leu Val Gly Asn Ile Tyr Val Asp Ser Asp 
945                 950                 955                 960 


Ala Leu Asn Val Ala Ser Glu Pro Thr Ala Asp Glu Asp Ala Ala His 
                965                 970                 975     


Val Pro His Ala Arg Asn Met Tyr Gly Glu Met Thr Ala Gly Thr Ile 
            980                 985                 990         


Lys Gly Trp Gln Asn Ala Val Arg  His Phe His Asn Lys  Leu Glu Thr 
        995                 1000                 1005             


Val Ala  Pro Thr Lys 
    1010             


<210>  11
<211>  2103
<212>  DNA
<213>  Psilocybe cubensis

<400>  11
atggaggcta tcaaaaaggt ttttgagaac aaaaaggcgg agggcattcc tgtgttggtg       60

acctttgtta ctgcaggata tcctcgtccc gaagatactg ttcccatctt gctggccatg      120

gaggccggtg gtgctgatat catcgagctt ggtatgccat tttcagaccc aattgcagat      180

ggtcctgtca tccaggaaac gaacacaatc gccgttgcaa accaggtaga ttataccact      240

gttctcggac aacttcggga agcccgcaaa caagggctca aggcacccgt tcttctgatg      300

ggatattata accccatatt ggcttacgga gaagacagat ctattcaaga tgcggctgaa      360

gctggagcca atgggtttat tatggtcgac cttccacccg aggaggctgt cgcttttcga      420

gagaaatgta tcaaatccaa cctctcatat gttcctctaa ttgcaccctc aacgactctg      480

tcgcgtataa agttcctctc aacaattgca gacacgttca tctatgtcgt gtctaaaatg      540

ggaaccaccg gatcctcaga gaaggttgcc atgaataacg cccttcccac catcatcgat      600

cgtattcgcg agtacgctga agttccttta gcagtcggat ttggagtcgc cactcgggct      660

cacttcaact acgtcgccga ttccggtgct gatggtgtcg ttattggcac caaactcgtt      720

aacgttatta aagagtcacc gcaaggggaa gcacccaaaa atgttgaggc atactgccgt      780

gagatgagcc aaaagggaga aacaaatcgc gtcaaatctc caccaactgc ccgtgctgcc      840

agctccgaat caattcctgt tgttgttcct tctgttctcc ccgcacgttt cggagaattc      900

ggaggacaat acgttcccga agctcttgtc gattgtctgg ttgaactaga agaagctcac      960

aaatctgcca tggctgatcc tgaattccag aaggaactac aatcgcatgc cggatatgca     1020

aatcgtcctt cacaaatata cctcgccgaa aatctcacca aggatgctgg gggtgcaaat     1080

atttggttga aacgtgaaga tttgaaccac acaggttccc acaaaatcaa taacgctttg     1140

ggacaaattc tgcttgcccg gagaatcgga aagaccagaa ttatcgcaga aacaggtgcc     1200

ggccagcatg gtgttgcaac agcgactgtt tgcgctaagt ttggaatgga atgtgttatc     1260

tacatgggcg cagaagatgt gcgacggcaa gctctaaatg tattcaggat tgagatgcta     1320

ggagcaaaag ttgttcctgt tacttcagga tcatgcacat tgaaggacgc tgtaaacgag     1380

gccttccgtg actgggtgac aaacctttct acgacgcatt atttggttgg ctctgtaatt     1440

ggacctcatc ccttccccac cattgtccga gatttccaaa aggtcattgg tcaagagatc     1500

aaggctcaga tgttggccgc ccgcggcaaa cttcctgatg tcgtcgtcgc ttgtgttggt     1560

ggaggaagca atgctatcgg tacgttctat gattttattg gcgacaagag tgtacgtcta     1620

gttggggtgg aagcaggagg agaaggtatt gacggagacc gacatagcgc cacactttcg     1680

atggggcaac cgggagtact tcacggtgtt agaacatata ttctacaaga caaggccggt     1740

caaatcatcg agacgcactc aatcagcgct ggattggatt atcccggcgt tggaccagaa     1800

catgcttggc taaaggactc taaaagagca gaatatgttg tcgccacaga cgaagaagca     1860

cttcgcggtt tccgtatgct aacacaaagg gagggaatta ttcctgccct tgaatcttcc     1920

catgcgatct gggaggctgt caggattgcc cgcaccatgt cgaaggacca ggatcttgtt     1980

gtgtgtttgt ctggccgagg tgataaagac gttgagcaaa tttctcaact tcttcccaag     2040

tgggcggata ttctagactg gcatgtttct tcccatgccg ttggacacac aacaaaattc     2100

taa                                                                   2103


<210>  12
<211>  700
<212>  PRT
<213>  Psilocybe cubensis

<400>  12

Met Glu Ala Ile Lys Lys Val Phe Glu Asn Lys Lys Ala Glu Gly Ile 
1               5                   10                  15      


Pro Val Leu Val Thr Phe Val Thr Ala Gly Tyr Pro Arg Pro Glu Asp 
            20                  25                  30          


Thr Val Pro Ile Leu Leu Ala Met Glu Ala Gly Gly Ala Asp Ile Ile 
        35                  40                  45              


Glu Leu Gly Met Pro Phe Ser Asp Pro Ile Ala Asp Gly Pro Val Ile 
    50                  55                  60                  


Gln Glu Thr Asn Thr Ile Ala Val Ala Asn Gln Val Asp Tyr Thr Thr 
65                  70                  75                  80  


Val Leu Gly Gln Leu Arg Glu Ala Arg Lys Gln Gly Leu Lys Ala Pro 
                85                  90                  95      


Val Leu Leu Met Gly Tyr Tyr Asn Pro Ile Leu Ala Tyr Gly Glu Asp 
            100                 105                 110         


Arg Ser Ile Gln Asp Ala Ala Glu Ala Gly Ala Asn Gly Phe Ile Met 
        115                 120                 125             


Val Asp Leu Pro Pro Glu Glu Ala Val Ala Phe Arg Glu Lys Cys Ile 
    130                 135                 140                 


Lys Ser Asn Leu Ser Tyr Val Pro Leu Ile Ala Pro Ser Thr Thr Leu 
145                 150                 155                 160 


Ser Arg Ile Lys Phe Leu Ser Thr Ile Ala Asp Thr Phe Ile Tyr Val 
                165                 170                 175     


Val Ser Lys Met Gly Thr Thr Gly Ser Ser Glu Lys Val Ala Met Asn 
            180                 185                 190         


Asn Ala Leu Pro Thr Ile Ile Asp Arg Ile Arg Glu Tyr Ala Glu Val 
        195                 200                 205             


Pro Leu Ala Val Gly Phe Gly Val Ala Thr Arg Ala His Phe Asn Tyr 
    210                 215                 220                 


Val Ala Asp Ser Gly Ala Asp Gly Val Val Ile Gly Thr Lys Leu Val 
225                 230                 235                 240 


Asn Val Ile Lys Glu Ser Pro Gln Gly Glu Ala Pro Lys Asn Val Glu 
                245                 250                 255     


Ala Tyr Cys Arg Glu Met Ser Gln Lys Gly Glu Thr Asn Arg Val Lys 
            260                 265                 270         


Ser Pro Pro Thr Ala Arg Ala Ala Ser Ser Glu Ser Ile Pro Val Val 
        275                 280                 285             


Val Pro Ser Val Leu Pro Ala Arg Phe Gly Glu Phe Gly Gly Gln Tyr 
    290                 295                 300                 


Val Pro Glu Ala Leu Val Asp Cys Leu Val Glu Leu Glu Glu Ala His 
305                 310                 315                 320 


Lys Ser Ala Met Ala Asp Pro Glu Phe Gln Lys Glu Leu Gln Ser His 
                325                 330                 335     


Ala Gly Tyr Ala Asn Arg Pro Ser Gln Ile Tyr Leu Ala Glu Asn Leu 
            340                 345                 350         


Thr Lys Asp Ala Gly Gly Ala Asn Ile Trp Leu Lys Arg Glu Asp Leu 
        355                 360                 365             


Asn His Thr Gly Ser His Lys Ile Asn Asn Ala Leu Gly Gln Ile Leu 
    370                 375                 380                 


Leu Ala Arg Arg Ile Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala 
385                 390                 395                 400 


Gly Gln His Gly Val Ala Thr Ala Thr Val Cys Ala Lys Phe Gly Met 
                405                 410                 415     


Glu Cys Val Ile Tyr Met Gly Ala Glu Asp Val Arg Arg Gln Ala Leu 
            420                 425                 430         


Asn Val Phe Arg Ile Glu Met Leu Gly Ala Lys Val Val Pro Val Thr 
        435                 440                 445             


Ser Gly Ser Cys Thr Leu Lys Asp Ala Val Asn Glu Ala Phe Arg Asp 
    450                 455                 460                 


Trp Val Thr Asn Leu Ser Thr Thr His Tyr Leu Val Gly Ser Val Ile 
465                 470                 475                 480 


Gly Pro His Pro Phe Pro Thr Ile Val Arg Asp Phe Gln Lys Val Ile 
                485                 490                 495     


Gly Gln Glu Ile Lys Ala Gln Met Leu Ala Ala Arg Gly Lys Leu Pro 
            500                 505                 510         


Asp Val Val Val Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Thr 
        515                 520                 525             


Phe Tyr Asp Phe Ile Gly Asp Lys Ser Val Arg Leu Val Gly Val Glu 
    530                 535                 540                 


Ala Gly Gly Glu Gly Ile Asp Gly Asp Arg His Ser Ala Thr Leu Ser 
545                 550                 555                 560 


Met Gly Gln Pro Gly Val Leu His Gly Val Arg Thr Tyr Ile Leu Gln 
                565                 570                 575     


Asp Lys Ala Gly Gln Ile Ile Glu Thr His Ser Ile Ser Ala Gly Leu 
            580                 585                 590         


Asp Tyr Pro Gly Val Gly Pro Glu His Ala Trp Leu Lys Asp Ser Lys 
        595                 600                 605             


Arg Ala Glu Tyr Val Val Ala Thr Asp Glu Glu Ala Leu Arg Gly Phe 
    610                 615                 620                 


Arg Met Leu Thr Gln Arg Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser 
625                 630                 635                 640 


His Ala Ile Trp Glu Ala Val Arg Ile Ala Arg Thr Met Ser Lys Asp 
                645                 650                 655     


Gln Asp Leu Val Val Cys Leu Ser Gly Arg Gly Asp Lys Asp Val Glu 
            660                 665                 670         


Gln Ile Ser Gln Leu Leu Pro Lys Trp Ala Asp Ile Leu Asp Trp His 
        675                 680                 685             


Val Ser Ser His Ala Val Gly His Thr Thr Lys Phe 
    690                 695                 700 


<210>  13
<211>  1599
<212>  DNA
<213>  Streptomyces rugosporus

<400>  13
atggaaaggc ggaagcgtga gcgtcttggc tcactcggcc gaccgaccaa aaaggagctc       60

cgcatgatcc gatctgtggt gatcgtgggt ggtggcacgg cgggctggat gaccgcctcc      120

tacctcaagg ccgccttcga cgaccgcatc gacgtaacgc tcgtggagtc agggaacgtc      180

aggcggatcg gggtcggcga agcgaccttc agcacggtcc gccacttctt cgactacctg      240

ggcctcgacg agcgcgagtg gctgccccgc tgcgccggcg gctacaagct cggcatccgc      300

ttcgagaact ggagcgagcc gggcgagtac ttctaccacc cgttcgagcg cctgcgcgtc      360

gtcgacggct tcaacatggc cgagtggtgg ctcgcggtcg gcgaccgcag gacgtccttc      420

agcgaggcct gctatctcac gcaccggctg tgcgaggcca agcgggcgcc ccgcatgctc      480

gacggctcgc tcttcgcctc ccaggtggac gagtcgctcg gccgctcgac cctggccgag      540

cagcgcgccc agttcccgta cgcctaccac ttcgacgccg acgaggtcgc ccgctacctg      600

tcggagtacg ccatcgcccg cggcgtccgc cacgtggtcg acgacgtgca gcacgtcggc      660

caggacgagc gcggctggat cagcggcgtc cacaccaagc agcacggcga gatcagcggc      720

gacctgttcg tcgactgcac cggcttccgc ggcctgctca tcaaccagac gctgggcggc      780

aggttccagt ccttctccga cgtgctgccc aacaaccggg cggtcgcgct gcgcgtcccg      840

cgggagaacg acgaggacat gcggccgtac acgacggcga ccgcgatgag cgccggctgg      900

atgtggacga tcccgctgtt caagcgcgac ggcaacggct acgtctactc cgacgagttc      960

atctcgccgg aggaggccga gcgcgagctg cggtccaccg tcgcccccgg ccgcgacgac     1020

ctggaggcca accacatcca gatgcggatc ggcaggaacg agcgcacctg gatcaacaac     1080

tgcgtcgccg tcggcctgtc cgccgccttc gtcgagccgc tggagtcgac cggcatcttc     1140

ttcatccagc acgccatcga gcagctcgtg aagcacttcc ccggcgagcg ctgggacccg     1200

gtgctgatca gcgcgtacaa cgagcgcatg gcgcacatgg tcgacggggt caaggagttc     1260

ctcgtcctcc actacaaggg cgcccagcgc gaggacaccc cctactggaa ggccgccaag     1320

accagggcca tgcccgacgg cctcgcccgc aagctggagc tgtccgcctc ccacctgctg     1380

gacgagcaga cgatctaccc ctactaccac ggcttcgaga cctattcgtg gatcaccatg     1440

aacctcggtc tcggcatcgt gcccgagcgg ccgcgtcccg cgctcctgca catggacccg     1500

gcgcccgcgc tggccgagtt cgaacggctc aggcgcgagg gcgacgagct gatcgccgcc     1560

ctgcccagct gctacgagta cctcgccagc atccaatga                            1599


<210>  14
<211>  532
<212>  PRT
<213>  Streptomyces rugosporus

<400>  14

Met Glu Arg Arg Lys Arg Glu Arg Leu Gly Ser Leu Gly Arg Pro Thr 
1               5                   10                  15      


Lys Lys Glu Leu Arg Met Ile Arg Ser Val Val Ile Val Gly Gly Gly 
            20                  25                  30          


Thr Ala Gly Trp Met Thr Ala Ser Tyr Leu Lys Ala Ala Phe Asp Asp 
        35                  40                  45              


Arg Ile Asp Val Thr Leu Val Glu Ser Gly Asn Val Arg Arg Ile Gly 
    50                  55                  60                  


Val Gly Glu Ala Thr Phe Ser Thr Val Arg His Phe Phe Asp Tyr Leu 
65                  70                  75                  80  


Gly Leu Asp Glu Arg Glu Trp Leu Pro Arg Cys Ala Gly Gly Tyr Lys 
                85                  90                  95      


Leu Gly Ile Arg Phe Glu Asn Trp Ser Glu Pro Gly Glu Tyr Phe Tyr 
            100                 105                 110         


His Pro Phe Glu Arg Leu Arg Val Val Asp Gly Phe Asn Met Ala Glu 
        115                 120                 125             


Trp Trp Leu Ala Val Gly Asp Arg Arg Thr Ser Phe Ser Glu Ala Cys 
    130                 135                 140                 


Tyr Leu Thr His Arg Leu Cys Glu Ala Lys Arg Ala Pro Arg Met Leu 
145                 150                 155                 160 


Asp Gly Ser Leu Phe Ala Ser Gln Val Asp Glu Ser Leu Gly Arg Ser 
                165                 170                 175     


Thr Leu Ala Glu Gln Arg Ala Gln Phe Pro Tyr Ala Tyr His Phe Asp 
            180                 185                 190         


Ala Asp Glu Val Ala Arg Tyr Leu Ser Glu Tyr Ala Ile Ala Arg Gly 
        195                 200                 205             


Val Arg His Val Val Asp Asp Val Gln His Val Gly Gln Asp Glu Arg 
    210                 215                 220                 


Gly Trp Ile Ser Gly Val His Thr Lys Gln His Gly Glu Ile Ser Gly 
225                 230                 235                 240 


Asp Leu Phe Val Asp Cys Thr Gly Phe Arg Gly Leu Leu Ile Asn Gln 
                245                 250                 255     


Thr Leu Gly Gly Arg Phe Gln Ser Phe Ser Asp Val Leu Pro Asn Asn 
            260                 265                 270         


Arg Ala Val Ala Leu Arg Val Pro Arg Glu Asn Asp Glu Asp Met Arg 
        275                 280                 285             


Pro Tyr Thr Thr Ala Thr Ala Met Ser Ala Gly Trp Met Trp Thr Ile 
    290                 295                 300                 


Pro Leu Phe Lys Arg Asp Gly Asn Gly Tyr Val Tyr Ser Asp Glu Phe 
305                 310                 315                 320 


Ile Ser Pro Glu Glu Ala Glu Arg Glu Leu Arg Ser Thr Val Ala Pro 
                325                 330                 335     


Gly Arg Asp Asp Leu Glu Ala Asn His Ile Gln Met Arg Ile Gly Arg 
            340                 345                 350         


Asn Glu Arg Thr Trp Ile Asn Asn Cys Val Ala Val Gly Leu Ser Ala 
        355                 360                 365             


Ala Phe Val Glu Pro Leu Glu Ser Thr Gly Ile Phe Phe Ile Gln His 
    370                 375                 380                 


Ala Ile Glu Gln Leu Val Lys His Phe Pro Gly Glu Arg Trp Asp Pro 
385                 390                 395                 400 


Val Leu Ile Ser Ala Tyr Asn Glu Arg Met Ala His Met Val Asp Gly 
                405                 410                 415     


Val Lys Glu Phe Leu Val Leu His Tyr Lys Gly Ala Gln Arg Glu Asp 
            420                 425                 430         


Thr Pro Tyr Trp Lys Ala Ala Lys Thr Arg Ala Met Pro Asp Gly Leu 
        435                 440                 445             


Ala Arg Lys Leu Glu Leu Ser Ala Ser His Leu Leu Asp Glu Gln Thr 
    450                 455                 460                 


Ile Tyr Pro Tyr Tyr His Gly Phe Glu Thr Tyr Ser Trp Ile Thr Met 
465                 470                 475                 480 


Asn Leu Gly Leu Gly Ile Val Pro Glu Arg Pro Arg Pro Ala Leu Leu 
                485                 490                 495     


His Met Asp Pro Ala Pro Ala Leu Ala Glu Phe Glu Arg Leu Arg Arg 
            500                 505                 510         


Glu Gly Asp Glu Leu Ile Ala Ala Leu Pro Ser Cys Tyr Glu Tyr Leu 
        515                 520                 525             


Ala Ser Ile Gln 
    530         


<210>  15
<211>  1518
<212>  DNA
<213>  Kutzneria sp. 744

<400>  15
atgaccgccg cctacctgaa gaccgcgttc ggcgaccggc tttcgatcac cgtcgtggaa       60

tcgagcagaa tcgggaccat cggcgtcggt gaggcgacct tcagcgacat ccagcacttc      120

ttccagttcc tcaacctccg ggaacaggac tggatgccgg cctgcaacgc cacctacaag      180

ctgggcatcc gcttcgagaa ctggcggcat gtcggccatc atttctacca gccgttcgag      240

cagatccgcc cggtctacgg ctttccgctg accgactggt ggctgcacga cgcgccgacc      300

gaccgcttcg acaccgactg cttcgtcatg cccaacctgt gcgaggccgg gcgcagcccg      360

cgccacctcg acggcacgct ggccgacgag gacttcgtgg aggagggcga cgagctcgcc      420

aaccgcacca tgtccgagca ccagggcaag tcgcagttcc cgtacgccta ccacttcgag      480

gcggcgctgc tggccaagtt cctcaccggg tacgcggtgg accgcggcgt cgagcacgtc      540

gtcgacgacg tcctggacgt gcggctggac cagcgcgggt ggatcgagca cgtggtcacc      600

gccgagcacg gcgagatcca cggcgacctg ttcgtcgact gcaccggttt ccggggactg      660

ctgctgaaca aggcgctcgg tgtgccgttc gtgtcctatc aggacactct gcccaacgac      720

agcgcggtcg ccctccaggt cccgctggac atgcagcggc gcggcatcgt gccgaacacc      780

acggccaccg cgcgggaggc cggctggatc tggaccatcc cgctgttcgg tcgggtcggc      840

accgggtacg tctacgccaa ggactacctc tcgcccgagg aggccgagcg cacgctgcgc      900

gagttcgtcg gcccggcggc cgcggacgtg gaggccaacc acatccgcat gcggatcggc      960

cgcagccagg agtcctggcg gaacaactgc gtggccatcg gcctgtccag cggcttcgtc     1020

gagccgctgg agtcgaccgg gatcttcttc atccaccacg ccatcgagca gctggtgaag     1080

cacttcccgg cggccgactg gaacccgaag tcccgggaca tgtacaactc cgcggtcgcg     1140

cacgtgatgg acggcatccg cgagttcctg gtgatccact accggggcgc ggcgcgggcc     1200

gacaaccagt actggcgcga caccaagacc cgcccgctgc cggacggcct ggccgagcgc     1260

atcgagtgct ggcagacgca gctgccggac accgagacga tctacccgta ctaccacggg     1320

ctgccgccct actcctacat gtgcatcctg atgggcggcg gggccatccg gacgccggcc     1380

tcggccgcgt tggccctgac cgaccagggg gccgcgcaga aggagttcgc cgccgtccgg     1440

gaccgggccg cgcagctgcg cgacacgctg cccagccact acgagtacct cgcgcggatg     1500

cgtggtctgg atgtctga                                                   1518


<210>  16
<211>  505
<212>  PRT
<213>  Kutzneria sp. 744

<400>  16

Met Thr Ala Ala Tyr Leu Lys Thr Ala Phe Gly Asp Arg Leu Ser Ile 
1               5                   10                  15      


Thr Val Val Glu Ser Ser Arg Ile Gly Thr Ile Gly Val Gly Glu Ala 
            20                  25                  30          


Thr Phe Ser Asp Ile Gln His Phe Phe Gln Phe Leu Asn Leu Arg Glu 
        35                  40                  45              


Gln Asp Trp Met Pro Ala Cys Asn Ala Thr Tyr Lys Leu Gly Ile Arg 
    50                  55                  60                  


Phe Glu Asn Trp Arg His Val Gly His His Phe Tyr Gln Pro Phe Glu 
65                  70                  75                  80  


Gln Ile Arg Pro Val Tyr Gly Phe Pro Leu Thr Asp Trp Trp Leu His 
                85                  90                  95      


Asp Ala Pro Thr Asp Arg Phe Asp Thr Asp Cys Phe Val Met Pro Asn 
            100                 105                 110         


Leu Cys Glu Ala Gly Arg Ser Pro Arg His Leu Asp Gly Thr Leu Ala 
        115                 120                 125             


Asp Glu Asp Phe Val Glu Glu Gly Asp Glu Leu Ala Asn Arg Thr Met 
    130                 135                 140                 


Ser Glu His Gln Gly Lys Ser Gln Phe Pro Tyr Ala Tyr His Phe Glu 
145                 150                 155                 160 


Ala Ala Leu Leu Ala Lys Phe Leu Thr Gly Tyr Ala Val Asp Arg Gly 
                165                 170                 175     


Val Glu His Val Val Asp Asp Val Leu Asp Val Arg Leu Asp Gln Arg 
            180                 185                 190         


Gly Trp Ile Glu His Val Val Thr Ala Glu His Gly Glu Ile His Gly 
        195                 200                 205             


Asp Leu Phe Val Asp Cys Thr Gly Phe Arg Gly Leu Leu Leu Asn Lys 
    210                 215                 220                 


Ala Leu Gly Val Pro Phe Val Ser Tyr Gln Asp Thr Leu Pro Asn Asp 
225                 230                 235                 240 


Ser Ala Val Ala Leu Gln Val Pro Leu Asp Met Gln Arg Arg Gly Ile 
                245                 250                 255     


Val Pro Asn Thr Thr Ala Thr Ala Arg Glu Ala Gly Trp Ile Trp Thr 
            260                 265                 270         


Ile Pro Leu Phe Gly Arg Val Gly Thr Gly Tyr Val Tyr Ala Lys Asp 
        275                 280                 285             


Tyr Leu Ser Pro Glu Glu Ala Glu Arg Thr Leu Arg Glu Phe Val Gly 
    290                 295                 300                 


Pro Ala Ala Ala Asp Val Glu Ala Asn His Ile Arg Met Arg Ile Gly 
305                 310                 315                 320 


Arg Ser Gln Glu Ser Trp Arg Asn Asn Cys Val Ala Ile Gly Leu Ser 
                325                 330                 335     


Ser Gly Phe Val Glu Pro Leu Glu Ser Thr Gly Ile Phe Phe Ile His 
            340                 345                 350         


His Ala Ile Glu Gln Leu Val Lys His Phe Pro Ala Ala Asp Trp Asn 
        355                 360                 365             


Pro Lys Ser Arg Asp Met Tyr Asn Ser Ala Val Ala His Val Met Asp 
    370                 375                 380                 


Gly Ile Arg Glu Phe Leu Val Ile His Tyr Arg Gly Ala Ala Arg Ala 
385                 390                 395                 400 


Asp Asn Gln Tyr Trp Arg Asp Thr Lys Thr Arg Pro Leu Pro Asp Gly 
                405                 410                 415     


Leu Ala Glu Arg Ile Glu Cys Trp Gln Thr Gln Leu Pro Asp Thr Glu 
            420                 425                 430         


Thr Ile Tyr Pro Tyr Tyr His Gly Leu Pro Pro Tyr Ser Tyr Met Cys 
        435                 440                 445             


Ile Leu Met Gly Gly Gly Ala Ile Arg Thr Pro Ala Ser Ala Ala Leu 
    450                 455                 460                 


Ala Leu Thr Asp Gln Gly Ala Ala Gln Lys Glu Phe Ala Ala Val Arg 
465                 470                 475                 480 


Asp Arg Ala Ala Gln Leu Arg Asp Thr Leu Pro Ser His Tyr Glu Tyr 
                485                 490                 495     


Leu Ala Arg Met Arg Gly Leu Asp Val 
            500                 505 


<210>  17
<211>  1572
<212>  DNA
<213>  Streptomyces toxytrinici

<400>  17
atgaacacga gaaatccgga caaggtcgtc atcgtcggcg gcggcacggc gggatggatg       60

accgcctcgt acctgaagaa ggcgttcggc gagcgcgtgt ccgtgaccct cgtcgaatcg      120

ggcaccatcg gcaccgtcgg cgtcggcgag gcgaccttca gcgacatccg gcacttcttc      180

gaattcctcg acctgcggga ggaggaatgg atgccggcct gcaacgccac gtacaagctg      240

gccgtccgct tccaggactg gcagcgcccc ggccaccact tctaccaccc gttcgagcag      300

atgcgctccg tagacgggtt ccccctgacc gactggtggc tgcagaacgg gccgaccgac      360

cggttcgaca gggactgctt cgtgatggcg tcgctgtgcg acgcggggcg cagcccgcgc      420

tatctcaacg gttccctgct gcagcaggag ttcgacgagc gcgcggagga gccggcgggg      480

ctcaccatgt ccgagcacca gggcaagacg cagttcccct acgcctacca cttcgaggcg      540

gccctgctcg ccgaattcct ttctgggtac tccaaggacc gcggcgtgaa gcacgtggtc      600

gacgaggtgc tggaggtgaa gctcgacgac cgcggatgga tcagccacgt tgtcaccaag      660

gagcacggcg acatcggcgg cgacctgttc gtcgactgca ccggtttccg cggcgtactg      720

ctgaaccagg cgctgggtgt gcccttcgtc tcctaccagg acaccctgcc caatgacagc      780

gcggtcgccc tccaggtgcc gctcgacatg gaggcgcggg gcatcccgcc gtacacccgg      840

gccaccgcca aggaggccgg gtggatctgg acgatcccgc tgatcggccg gatcggcacc      900

gggtacgtgt acgccaagga ctactgctcg ccggaggagg ccgagcgcac cctgcgcgag      960

ttcgtcggtc cggaggccgc cgacgtcgag gccaaccaca tccgcatgcg gatcgggcgc     1020

agcgagcagt cctggaagaa caactgcgtc gcgatcgggc tctccagtgg cttcgtcgaa     1080

cccctcgagt cgaccggcat cttcttcatc caccacgcca tcgagcagtt ggtgaagcac     1140

ttcccggcgg gcgactggca cccgcagctg cgcgccggct acaactcggc cgtcgccaac     1200

gtcatggacg gggtccggga gttcctcgtc ctgcactacc tgggcgccgc gcgcaacgac     1260

acccggtact ggaaggacac caagacccgg gcggttccgg atgccctggc ggagcgcatc     1320

gagcgctgga aggtgcagct gcccgactcc gagaacgtct tcccctacta ccacggcctg     1380

ccgccgtact cgtacatggc catcctgctc gggaccggcg cgatcgggct gcgaccgtcg     1440

ccggcgctcg cactggccga cccggcggcg gcggagaagg agttcaccgc gatccgggac     1500

agggcgcggt tcctggtcga caccctgccg agccagtacg agtacttcgc cgcgatgggg     1560

cagcgtgtct ga                                                         1572


<210>  18
<211>  523
<212>  PRT
<213>  Streptomyces toxytrinici

<400>  18

Met Asn Thr Arg Asn Pro Asp Lys Val Val Ile Val Gly Gly Gly Thr 
1               5                   10                  15      


Ala Gly Trp Met Thr Ala Ser Tyr Leu Lys Lys Ala Phe Gly Glu Arg 
            20                  25                  30          


Val Ser Val Thr Leu Val Glu Ser Gly Thr Ile Gly Thr Val Gly Val 
        35                  40                  45              


Gly Glu Ala Thr Phe Ser Asp Ile Arg His Phe Phe Glu Phe Leu Asp 
    50                  55                  60                  


Leu Arg Glu Glu Glu Trp Met Pro Ala Cys Asn Ala Thr Tyr Lys Leu 
65                  70                  75                  80  


Ala Val Arg Phe Gln Asp Trp Gln Arg Pro Gly His His Phe Tyr His 
                85                  90                  95      


Pro Phe Glu Gln Met Arg Ser Val Asp Gly Phe Pro Leu Thr Asp Trp 
            100                 105                 110         


Trp Leu Gln Asn Gly Pro Thr Asp Arg Phe Asp Arg Asp Cys Phe Val 
        115                 120                 125             


Met Ala Ser Leu Cys Asp Ala Gly Arg Ser Pro Arg Tyr Leu Asn Gly 
    130                 135                 140                 


Ser Leu Leu Gln Gln Glu Phe Asp Glu Arg Ala Glu Glu Pro Ala Gly 
145                 150                 155                 160 


Leu Thr Met Ser Glu His Gln Gly Lys Thr Gln Phe Pro Tyr Ala Tyr 
                165                 170                 175     


His Phe Glu Ala Ala Leu Leu Ala Glu Phe Leu Ser Gly Tyr Ser Lys 
            180                 185                 190         


Asp Arg Gly Val Lys His Val Val Asp Glu Val Leu Glu Val Lys Leu 
        195                 200                 205             


Asp Asp Arg Gly Trp Ile Ser His Val Val Thr Lys Glu His Gly Asp 
    210                 215                 220                 


Ile Gly Gly Asp Leu Phe Val Asp Cys Thr Gly Phe Arg Gly Val Leu 
225                 230                 235                 240 


Leu Asn Gln Ala Leu Gly Val Pro Phe Val Ser Tyr Gln Asp Thr Leu 
                245                 250                 255     


Pro Asn Asp Ser Ala Val Ala Leu Gln Val Pro Leu Asp Met Glu Ala 
            260                 265                 270         


Arg Gly Ile Pro Pro Tyr Thr Arg Ala Thr Ala Lys Glu Ala Gly Trp 
        275                 280                 285             


Ile Trp Thr Ile Pro Leu Ile Gly Arg Ile Gly Thr Gly Tyr Val Tyr 
    290                 295                 300                 


Ala Lys Asp Tyr Cys Ser Pro Glu Glu Ala Glu Arg Thr Leu Arg Glu 
305                 310                 315                 320 


Phe Val Gly Pro Glu Ala Ala Asp Val Glu Ala Asn His Ile Arg Met 
                325                 330                 335     


Arg Ile Gly Arg Ser Glu Gln Ser Trp Lys Asn Asn Cys Val Ala Ile 
            340                 345                 350         


Gly Leu Ser Ser Gly Phe Val Glu Pro Leu Glu Ser Thr Gly Ile Phe 
        355                 360                 365             


Phe Ile His His Ala Ile Glu Gln Leu Val Lys His Phe Pro Ala Gly 
    370                 375                 380                 


Asp Trp His Pro Gln Leu Arg Ala Gly Tyr Asn Ser Ala Val Ala Asn 
385                 390                 395                 400 


Val Met Asp Gly Val Arg Glu Phe Leu Val Leu His Tyr Leu Gly Ala 
                405                 410                 415     


Ala Arg Asn Asp Thr Arg Tyr Trp Lys Asp Thr Lys Thr Arg Ala Val 
            420                 425                 430         


Pro Asp Ala Leu Ala Glu Arg Ile Glu Arg Trp Lys Val Gln Leu Pro 
        435                 440                 445             


Asp Ser Glu Asn Val Phe Pro Tyr Tyr His Gly Leu Pro Pro Tyr Ser 
    450                 455                 460                 


Tyr Met Ala Ile Leu Leu Gly Thr Gly Ala Ile Gly Leu Arg Pro Ser 
465                 470                 475                 480 


Pro Ala Leu Ala Leu Ala Asp Pro Ala Ala Ala Glu Lys Glu Phe Thr 
                485                 490                 495     


Ala Ile Arg Asp Arg Ala Arg Phe Leu Val Asp Thr Leu Pro Ser Gln 
            500                 505                 510         


Tyr Glu Tyr Phe Ala Ala Met Gly Gln Arg Val 
        515                 520             


<210>  19
<211>  1596
<212>  DNA
<213>  Streptomyces albogriseolus

<400>  19
atggacaatc gaatcaagac agtcgtgatc ctgggcggcg gcaccgccgg ctggatgact       60

gcggcgtatc tcggcaaggc gctgcagaac acggtgaaga tcgtggtcct ggaggcgccc      120

accatcccgc ggatcggtgt gggcgaagcc accgtcccca acctgcagcg cgcgttcttc      180

gactacctcg gcatccccga ggaggagtgg atgcgcgagt gcaacgccag ttacaagatg      240

gcggtgaagt tcatcaactg gcgcacaccg ggggagggca gcccggatcc ccggacgctc      300

gacgacggtc acaccgacac cttccaccac cccttcggac tgctgccgtc cgccgaccag      360

ataccgctct cccactactg ggcggccaag cggctccagg gcgagaccga cgagaacttc      420

gacgaggcgt gtttcgccga caccgcgatc atgaacgcca agaaggcgcc ccgcttcctc      480

gacatgcggc gggcgaccaa ctacgcctgg cacttcgacg ccagcaaggt cgccgcgttc      540

ctgcgcaact tcgccgtcac caagcaggcg gtcgagcacg tcgaggacga gatgaccgag      600

gtcctcaccg acgaacgggg cttcatcacc gccctgcgca ccaagtcggg acggatcctg      660

cagggtgacc tcttcgtcga ctgctccggc ttccgcgggc tgctgatcaa caaggccatg      720

gaggagccgt tcatcgacat gagcgaccac ctcctgtgca acagcgcggt cgccacggcc      780

gtaccgcacg acgacgagaa gaacggtgtc gagccgtaca cctcctcgat cgccatggag      840

gccggctgga cctggaagat tcccatgctg ggccggttcg gcagcggtca cgtctactcc      900

gaccacttcg ccacccagga cgaggccacc ctggccttct cgaagctgtg gggcctcgac      960

ccggacaaca ccgagttcaa ccacgtccgc ttccgggtcg gccgcaaccg cagggcctgg     1020

gtgcgcaact gcgtcagcgt cggcctcgcg tcgtgcttcg tggagccgct ggagtccagc     1080

ggcatctact tcatctacgc ggccatccac atgctggcca agcacttccc cgacaagacc     1140

ttcgacaagg tgctcgtcga ccggttcaac cgggagatcg aggagatgtt cgacgacacc     1200

cgggacttcc tccaggcgca ctactacttc tcgccgcgcg tcgacacgcc gttctggcgg     1260

gcgaacaagg aactgaagct ggccgactcc atcaaggaca aggtcgagac gtaccgggcc     1320

gggctgccgg tcaacctgcc ggtcaccgac gaggggacct actacggcaa cttcgaggcc     1380

gagttccgga acttctggac caacggcagc tactactgca tcttcgccgg cctcggcctg     1440

atgccgcgca acccgctgcc cgcgctcgcc tacaagccgc agtcgatcgc ggaggccgag     1500

ctgctgttcg ccgacgtcaa gcgcaagggg gacaccctgg tcgagtcgct gccgtcgacc     1560

tatgacctgc tgcgtcagtt gcacggtgcg tcgtga                               1596


<210>  20
<211>  531
<212>  PRT
<213>  Streptomyces albogriseolus

<400>  20

Met Asp Asn Arg Ile Lys Thr Val Val Ile Leu Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Thr Ala Ala Tyr Leu Gly Lys Ala Leu Gln Asn Thr Val 
            20                  25                  30          


Lys Ile Val Val Leu Glu Ala Pro Thr Ile Pro Arg Ile Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Val Pro Asn Leu Gln Arg Ala Phe Phe Asp Tyr Leu Gly 
    50                  55                  60                  


Ile Pro Glu Glu Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Met 
65                  70                  75                  80  


Ala Val Lys Phe Ile Asn Trp Arg Thr Pro Gly Glu Gly Ser Pro Asp 
                85                  90                  95      


Pro Arg Thr Leu Asp Asp Gly His Thr Asp Thr Phe His His Pro Phe 
            100                 105                 110         


Gly Leu Leu Pro Ser Ala Asp Gln Ile Pro Leu Ser His Tyr Trp Ala 
        115                 120                 125             


Ala Lys Arg Leu Gln Gly Glu Thr Asp Glu Asn Phe Asp Glu Ala Cys 
    130                 135                 140                 


Phe Ala Asp Thr Ala Ile Met Asn Ala Lys Lys Ala Pro Arg Phe Leu 
145                 150                 155                 160 


Asp Met Arg Arg Ala Thr Asn Tyr Ala Trp His Phe Asp Ala Ser Lys 
                165                 170                 175     


Val Ala Ala Phe Leu Arg Asn Phe Ala Val Thr Lys Gln Ala Val Glu 
            180                 185                 190         


His Val Glu Asp Glu Met Thr Glu Val Leu Thr Asp Glu Arg Gly Phe 
        195                 200                 205             


Ile Thr Ala Leu Arg Thr Lys Ser Gly Arg Ile Leu Gln Gly Asp Leu 
    210                 215                 220                 


Phe Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met 
225                 230                 235                 240 


Glu Glu Pro Phe Ile Asp Met Ser Asp His Leu Leu Cys Asn Ser Ala 
                245                 250                 255     


Val Ala Thr Ala Val Pro His Asp Asp Glu Lys Asn Gly Val Glu Pro 
            260                 265                 270         


Tyr Thr Ser Ser Ile Ala Met Glu Ala Gly Trp Thr Trp Lys Ile Pro 
        275                 280                 285             


Met Leu Gly Arg Phe Gly Ser Gly His Val Tyr Ser Asp His Phe Ala 
    290                 295                 300                 


Thr Gln Asp Glu Ala Thr Leu Ala Phe Ser Lys Leu Trp Gly Leu Asp 
305                 310                 315                 320 


Pro Asp Asn Thr Glu Phe Asn His Val Arg Phe Arg Val Gly Arg Asn 
                325                 330                 335     


Arg Arg Ala Trp Val Arg Asn Cys Val Ser Val Gly Leu Ala Ser Cys 
            340                 345                 350         


Phe Val Glu Pro Leu Glu Ser Ser Gly Ile Tyr Phe Ile Tyr Ala Ala 
        355                 360                 365             


Ile His Met Leu Ala Lys His Phe Pro Asp Lys Thr Phe Asp Lys Val 
    370                 375                 380                 


Leu Val Asp Arg Phe Asn Arg Glu Ile Glu Glu Met Phe Asp Asp Thr 
385                 390                 395                 400 


Arg Asp Phe Leu Gln Ala His Tyr Tyr Phe Ser Pro Arg Val Asp Thr 
                405                 410                 415     


Pro Phe Trp Arg Ala Asn Lys Glu Leu Lys Leu Ala Asp Ser Ile Lys 
            420                 425                 430         


Asp Lys Val Glu Thr Tyr Arg Ala Gly Leu Pro Val Asn Leu Pro Val 
        435                 440                 445             


Thr Asp Glu Gly Thr Tyr Tyr Gly Asn Phe Glu Ala Glu Phe Arg Asn 
    450                 455                 460                 


Phe Trp Thr Asn Gly Ser Tyr Tyr Cys Ile Phe Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Met Pro Arg Asn Pro Leu Pro Ala Leu Ala Tyr Lys Pro Gln Ser Ile 
                485                 490                 495     


Ala Glu Ala Glu Leu Leu Phe Ala Asp Val Lys Arg Lys Gly Asp Thr 
            500                 505                 510         


Leu Val Glu Ser Leu Pro Ser Thr Tyr Asp Leu Leu Arg Gln Leu His 
        515                 520                 525             


Gly Ala Ser 
    530     


<210>  21
<211>  1590
<212>  DNA
<213>  BorH halogenase

<400>  21
atggacaacc gcatcaaccg gatcgtcatc ctcggcggcg ggaccgcggg atggatgacc       60

gcctcctacc tggcgaaggc gctcggtgac accgtcacga tcaccctgct ggaagcaccg      120

gcgatcggcc ggatcggggt cggcgaggcc accgtgccca acctgcagcg cgtgttcttc      180

gacttcctcg gcctccgcga ggaggagtgg atgccggagt gcaacgccgc gttcaagacg      240

gccgtgaagt tcatcaactg gcgtaccccc gggcccggcg aggccaaggc ccgcacgatc      300

gacggccggc cggaccactt ctaccacccg ttcgggctgc tgcccgagca cggccaggtg      360

ccgctgtcgc actactgggc ctacaaccgg gcggccggca ccaccgacga gccgttcgac      420

tacgcctgtt tcgccgagac cgccgccatg gacgcggtcc gcgcgcccaa gtggctcgac      480

gggcggcccg ccacccggta tgcctggcac ttcgacgccc acctggtcgc cgagttcctg      540

cgccggcacg ccaccgagcg gctcaacgtg gagcacgtgc agggtgagat gcagcaggtg      600

ctgcgcgacg agcggggctt catcaccgcc ctgcgcacgg tcgagggccg ggacctcgag      660

ggtgacctgt tcatcgactg ctccggcttc cgcggcctgc tgatcaacaa ggccatggag      720

gagcccttca tcgacatgaa cgaccagctg ctgtgcaacc gcgcggtggc cacggcgatc      780

aagcacgacg acgacgcgca cggggtcgag ccgtacacct cggcgatcgc catgcggtcc      840

ggctggagct ggaagatccc gatgctgggc cgcttcggga ccggctacgt ctactccagc      900

cggttcgccg agaaggacga ggccaccctc gacttctgcc ggatgtgggg cctggacccg      960

gagaacaccc cgctcaacca ggtggccttc cgggtcggcc gcaaccgccg ggcctgggtg     1020

aagaactgcg tgagcatcgg cctggcgtcg tgcttcctgg agccactgga gtccaccggc     1080

atctacttca tcaccgcggc catctaccag ctgactcagc acttcccgga ccgcaccttc     1140

gcgctcgcgt tgagcgacgc gttcaaccac gagatcgaag ccatgttcga cgacacccgg     1200

gacttcatcc aggcgcactt ctacgtgtcg ccgcgcaccg acacgccgtt ctggaaggcg     1260

aacaaggacc tgcacctgcc cgagcagatg cgcgagaaga tcgcgatgta caaggccggc     1320

ctgccgatca acgcgccggt caccgacgag tcgacctact acggcaggtt cgaggccgag     1380

ttccgcaact tctggaccaa cggcagctac tactgcatct tcgcgggcct cgggctgcgc     1440

ccggacaacc cgctgccgat gctgcgacac cgtccggagc aggtccgcga ggcgcaggcg     1500

ctgttcgccg gggtgaagga caagcagcgg gagttggtgg agacgctgcc gagcaacctg     1560

gagttcctgc gcagcctgca cggcaagtag                                      1590


<210>  22
<211>  529
<212>  PRT
<213>  BorH halogenase

<400>  22

Met Asp Asn Arg Ile Asn Arg Ile Val Ile Leu Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Thr Ala Ser Tyr Leu Ala Lys Ala Leu Gly Asp Thr Val 
            20                  25                  30          


Thr Ile Thr Leu Leu Glu Ala Pro Ala Ile Gly Arg Ile Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Val Pro Asn Leu Gln Arg Val Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Leu Arg Glu Glu Glu Trp Met Pro Glu Cys Asn Ala Ala Phe Lys Thr 
65                  70                  75                  80  


Ala Val Lys Phe Ile Asn Trp Arg Thr Pro Gly Pro Gly Glu Ala Lys 
                85                  90                  95      


Ala Arg Thr Ile Asp Gly Arg Pro Asp His Phe Tyr His Pro Phe Gly 
            100                 105                 110         


Leu Leu Pro Glu His Gly Gln Val Pro Leu Ser His Tyr Trp Ala Tyr 
        115                 120                 125             


Asn Arg Ala Ala Gly Thr Thr Asp Glu Pro Phe Asp Tyr Ala Cys Phe 
    130                 135                 140                 


Ala Glu Thr Ala Ala Met Asp Ala Val Arg Ala Pro Lys Trp Leu Asp 
145                 150                 155                 160 


Gly Arg Pro Ala Thr Arg Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Glu Phe Leu Arg Arg His Ala Thr Glu Arg Leu Asn Val Glu His 
            180                 185                 190         


Val Gln Gly Glu Met Gln Gln Val Leu Arg Asp Glu Arg Gly Phe Ile 
        195                 200                 205             


Thr Ala Leu Arg Thr Val Glu Gly Arg Asp Leu Glu Gly Asp Leu Phe 
    210                 215                 220                 


Ile Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Ile Asp Met Asn Asp Gln Leu Leu Cys Asn Arg Ala Val 
                245                 250                 255     


Ala Thr Ala Ile Lys His Asp Asp Asp Ala His Gly Val Glu Pro Tyr 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Arg Ser Gly Trp Ser Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Glu 
    290                 295                 300                 


Lys Asp Glu Ala Thr Leu Asp Phe Cys Arg Met Trp Gly Leu Asp Pro 
305                 310                 315                 320 


Glu Asn Thr Pro Leu Asn Gln Val Ala Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Lys Asn Cys Val Ser Ile Gly Leu Ala Ser Cys Phe 
            340                 345                 350         


Leu Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Ile Thr Ala Ala Ile 
        355                 360                 365             


Tyr Gln Leu Thr Gln His Phe Pro Asp Arg Thr Phe Ala Leu Ala Leu 
    370                 375                 380                 


Ser Asp Ala Phe Asn His Glu Ile Glu Ala Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Val Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Lys Ala Asn Lys Asp Leu His Leu Pro Glu Gln Met Arg Glu 
            420                 425                 430         


Lys Ile Ala Met Tyr Lys Ala Gly Leu Pro Ile Asn Ala Pro Val Thr 
        435                 440                 445             


Asp Glu Ser Thr Tyr Tyr Gly Arg Phe Glu Ala Glu Phe Arg Asn Phe 
    450                 455                 460                 


Trp Thr Asn Gly Ser Tyr Tyr Cys Ile Phe Ala Gly Leu Gly Leu Arg 
465                 470                 475                 480 


Pro Asp Asn Pro Leu Pro Met Leu Arg His Arg Pro Glu Gln Val Arg 
                485                 490                 495     


Glu Ala Gln Ala Leu Phe Ala Gly Val Lys Asp Lys Gln Arg Glu Leu 
            500                 505                 510         


Val Glu Thr Leu Pro Ser Asn Leu Glu Phe Leu Arg Ser Leu His Gly 
        515                 520                 525             


Lys 
    


<210>  23
<211>  1602
<212>  DNA
<213>  Kutzneria sp. 744

<400>  23
atggatgaca atcgaattcg gagcatcctt gtccttggcg gcggcacggc cggctggatg       60

tccgcctgct acctgagcaa ggcgctcggg cccggcgtcg aggtcaccgt gctcgaggcg      120

ccctccatct cgcgcatccg ggtcggcgag gccaccattc ccaacctgca caaggtcttc      180

ttcgacttcc tgggcatcgc cgaggacgag tggatgcggg agtgcaacgc cagctacaag      240

gccgcggtcc ggttcgtcaa ctggcggacg ccgggcgacg gccaggccac gccgcggcgg      300

cgtccggacg gccgccccga ccacttcgac cacctgttcg gccagctgcc cgagcacgag      360

aacctgccgc tgtcgcagta ctgggcgcac cggcgcctca acggcctgac cgacgaaccc      420

ttcgaccgct cctgctacgt gcagcccgag ctgctggacc gcaagctctc gccgaggttg      480

atggacggca cgaaactggc cagctacgcc tggcacttcg acgccgacct ggtggccgac      540

ttcctctgcc ggttcgccgt gcagaagctg aacgtgaccc acgtccagga cgtgttcacg      600

catgccgacc tcgaccagcg cggccacatc acggccgtca acaccgagtc cggccgcacg      660

ctggccgccg acctgttcat cgactgcagc ggcttccgca gcgtgctcat gggcaaggtc      720

atgcaggagc cgttcctgga catgagcaag cacctgctca acgaccgcgc ggtggcgctg      780

atgctcccgc acgacgacga gaaggtgggc atcgagccgt acacctcgtc gctggccatg      840

cggtcgggct ggtcgtggaa gatcccgctg ctcggccggt tcggctccgg ctacgtctac      900

tccagccagt tcacctccca ggacgaggcg gccgaggagc tctgccgcat gtgggacgtc      960

gacccggcgg agcagacgtt caacaacgtc cggttccggg tcggccgcag ccgccgggcc     1020

tgggtgcgca actgcgtcgc catcggcgtg tccgccatgt tcgtggagcc gctggagtcg     1080

accggcctgt acttcagtta cgcctcgctc taccagctgg tgaagcactt cccggacaag     1140

cggttccggc cgatcctggc cgaccggttc aaccgcgagg tggcgaccat gtacgacgac     1200

acccgcgact tcctccaggc gcacttcagc ctgtcgccgc gtgacgactc cgagttctgg     1260

cgggcctgca aggagctgcc gttcgcggac gggttcgccg agaaggtcga gatgtacagg     1320

gccgggctgc cggtcgaact gccggtcacc atcgacgacg ggcactacta cggcaatttc     1380

gaggccgagt tccgcaactt ctggaccaac tcgaactact actgcatctt cgccgggctc     1440

ggtttcctgc ccgagcatcc gctgccggtg ctcgaattcc gcccggaggc cgtcgatcgc     1500

gcggagccgg tgttcgccgc ggtgcgccgg cgcacggagg agctggtcgc caccgccccg     1560

accatgcagg cctacctgcg gcgcctgcac cagggcacgt ag                        1602


<210>  24
<211>  533
<212>  PRT
<213>  Kutzneria sp. 744

<400>  24

Met Asp Asp Asn Arg Ile Arg Ser Ile Leu Val Leu Gly Gly Gly Thr 
1               5                   10                  15      


Ala Gly Trp Met Ser Ala Cys Tyr Leu Ser Lys Ala Leu Gly Pro Gly 
            20                  25                  30          


Val Glu Val Thr Val Leu Glu Ala Pro Ser Ile Ser Arg Ile Arg Val 
        35                  40                  45              


Gly Glu Ala Thr Ile Pro Asn Leu His Lys Val Phe Phe Asp Phe Leu 
    50                  55                  60                  


Gly Ile Ala Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys 
65                  70                  75                  80  


Ala Ala Val Arg Phe Val Asn Trp Arg Thr Pro Gly Asp Gly Gln Ala 
                85                  90                  95      


Thr Pro Arg Arg Arg Pro Asp Gly Arg Pro Asp His Phe Asp His Leu 
            100                 105                 110         


Phe Gly Gln Leu Pro Glu His Glu Asn Leu Pro Leu Ser Gln Tyr Trp 
        115                 120                 125             


Ala His Arg Arg Leu Asn Gly Leu Thr Asp Glu Pro Phe Asp Arg Ser 
    130                 135                 140                 


Cys Tyr Val Gln Pro Glu Leu Leu Asp Arg Lys Leu Ser Pro Arg Leu 
145                 150                 155                 160 


Met Asp Gly Thr Lys Leu Ala Ser Tyr Ala Trp His Phe Asp Ala Asp 
                165                 170                 175     


Leu Val Ala Asp Phe Leu Cys Arg Phe Ala Val Gln Lys Leu Asn Val 
            180                 185                 190         


Thr His Val Gln Asp Val Phe Thr His Ala Asp Leu Asp Gln Arg Gly 
        195                 200                 205             


His Ile Thr Ala Val Asn Thr Glu Ser Gly Arg Thr Leu Ala Ala Asp 
    210                 215                 220                 


Leu Phe Ile Asp Cys Ser Gly Phe Arg Ser Val Leu Met Gly Lys Val 
225                 230                 235                 240 


Met Gln Glu Pro Phe Leu Asp Met Ser Lys His Leu Leu Asn Asp Arg 
                245                 250                 255     


Ala Val Ala Leu Met Leu Pro His Asp Asp Glu Lys Val Gly Ile Glu 
            260                 265                 270         


Pro Tyr Thr Ser Ser Leu Ala Met Arg Ser Gly Trp Ser Trp Lys Ile 
        275                 280                 285             


Pro Leu Leu Gly Arg Phe Gly Ser Gly Tyr Val Tyr Ser Ser Gln Phe 
    290                 295                 300                 


Thr Ser Gln Asp Glu Ala Ala Glu Glu Leu Cys Arg Met Trp Asp Val 
305                 310                 315                 320 


Asp Pro Ala Glu Gln Thr Phe Asn Asn Val Arg Phe Arg Val Gly Arg 
                325                 330                 335     


Ser Arg Arg Ala Trp Val Arg Asn Cys Val Ala Ile Gly Val Ser Ala 
            340                 345                 350         


Met Phe Val Glu Pro Leu Glu Ser Thr Gly Leu Tyr Phe Ser Tyr Ala 
        355                 360                 365             


Ser Leu Tyr Gln Leu Val Lys His Phe Pro Asp Lys Arg Phe Arg Pro 
    370                 375                 380                 


Ile Leu Ala Asp Arg Phe Asn Arg Glu Val Ala Thr Met Tyr Asp Asp 
385                 390                 395                 400 


Thr Arg Asp Phe Leu Gln Ala His Phe Ser Leu Ser Pro Arg Asp Asp 
                405                 410                 415     


Ser Glu Phe Trp Arg Ala Cys Lys Glu Leu Pro Phe Ala Asp Gly Phe 
            420                 425                 430         


Ala Glu Lys Val Glu Met Tyr Arg Ala Gly Leu Pro Val Glu Leu Pro 
        435                 440                 445             


Val Thr Ile Asp Asp Gly His Tyr Tyr Gly Asn Phe Glu Ala Glu Phe 
    450                 455                 460                 


Arg Asn Phe Trp Thr Asn Ser Asn Tyr Tyr Cys Ile Phe Ala Gly Leu 
465                 470                 475                 480 


Gly Phe Leu Pro Glu His Pro Leu Pro Val Leu Glu Phe Arg Pro Glu 
                485                 490                 495     


Ala Val Asp Arg Ala Glu Pro Val Phe Ala Ala Val Arg Arg Arg Thr 
            500                 505                 510         


Glu Glu Leu Val Ala Thr Ala Pro Thr Met Gln Ala Tyr Leu Arg Arg 
        515                 520                 525             


Leu His Gln Gly Thr 
    530             


<210>  25
<211>  1617
<212>  DNA
<213>  Pseudomonas fluorescens

<400>  25
atgaacaagc cgatcaagaa tatcgtcatc gtgggcggcg gtactgcggg ctggatggcc       60

gcctcgtacc tcgtccgggc cctccaacag caggcgaaca ttacgctcat cgaatctgcg      120

gcgatccctc ggatcggcgt gggcgaagcg accatcccaa gtttgcagaa ggtgttcttc      180

gatttcctcg ggataccgga gcgggaatgg atgccccaag tgaacggcgc gttcaaggcc      240

gcgatcaagt tcgtgaattg gagaaagtct cccgacccct cgcgcgacga tcacttctac      300

catttgttcg gcaacgtgcc gaactgcgac ggcgtgccgc ttacccacta ctggctgcgc      360

aagcgcgaac agggcttcca gcagccgatg gagtacgcgt gctacccgca gcccggggca      420

ctcgacggca agctggcacc gtgcctgtcc gacggcaccc gccagatgtc ccacgcgtgg      480

cacttcgacg cgcacctggt ggccgacttc ttgaagcgct gggccgtcga gcgcggggtg      540

aaccgcgtgg tcgatgaggt ggtggacgtt cgcctgaaca accgcggcta catctccaac      600

ctgctcacca aggaggggcg gacgctggag gcggacctgt tcatcgactg ctccggcatg      660

cgggggctcc tgatcaatca ggcgctgaag gaacccttca tcgacatgtc cgactacctg      720

ctgtgcgaca gcgcggtcgc cagcgccgtg cccaacgacg acgcgcgcga tggggtcgag      780

ccgtacacct cctcgatcgc catgaactcg ggatggacct ggaagattcc gatgctgggc      840

cggttcggca gcggctacgt cttctcgagc catttcacct cgcgcgacca ggccaccgcc      900

gacttcctca aactctgggg cctctcggac aatcagccgc tcaaccagat caagttccgg      960

gtcgggcgca acaagcgggc gtgggtcaac aactgcgtct cgatcgggct gtcgtcgtgc     1020

tttctggagc ccctggaatc gacggggatc tacttcatct acgcggcgct ttaccagctc     1080

gtgaagcact tccccgacac ctcgttcgac ccgcggctga gcgacgcttt caacgccgag     1140

atcgtccaca tgttcgacga ctgccgggat ttcgtccaag cgcactattt caccacgtcg     1200

cgcgatgaca cgccgttctg gctcgcgaac cggcacgacc tgcggctctc ggacgccatc     1260

aaagagaagg ttcagcgcta caaggcgggg ctgccgctga ccaccacgtc gttcgacgat     1320

tccacgtact acgagacctt cgactacgaa ttcaagaatt tctggttgaa cggcaactac     1380

tactgcatct ttgccggctt gggcatgctg cccgaccggt cgctgccgct gttgcagcac     1440

cgaccggagt cgatcgagaa agccgaggcg atgttcgcca gcatccggcg cgaggccgag     1500

cgtctgcgca ccagcctgcc gacaaactac gactacctgc ggtcgctgcg tgacggcgac     1560

gcggggctgt cgcgcggcca gcgtgggccg aagctcgcag cgcaggaaag cctgtag        1617


<210>  26
<211>  538
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  26

Met Asn Lys Pro Ile Lys Asn Ile Val Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Val Arg Ala Leu Gln Gln Gln Ala 
            20                  25                  30          


Asn Ile Thr Leu Ile Glu Ser Ala Ala Ile Pro Arg Ile Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Ile Pro Ser Leu Gln Lys Val Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Arg Glu Trp Met Pro Gln Val Asn Gly Ala Phe Lys Ala 
65                  70                  75                  80  


Ala Ile Lys Phe Val Asn Trp Arg Lys Ser Pro Asp Pro Ser Arg Asp 
                85                  90                  95      


Asp His Phe Tyr His Leu Phe Gly Asn Val Pro Asn Cys Asp Gly Val 
            100                 105                 110         


Pro Leu Thr His Tyr Trp Leu Arg Lys Arg Glu Gln Gly Phe Gln Gln 
        115                 120                 125             


Pro Met Glu Tyr Ala Cys Tyr Pro Gln Pro Gly Ala Leu Asp Gly Lys 
    130                 135                 140                 


Leu Ala Pro Cys Leu Ser Asp Gly Thr Arg Gln Met Ser His Ala Trp 
145                 150                 155                 160 


His Phe Asp Ala His Leu Val Ala Asp Phe Leu Lys Arg Trp Ala Val 
                165                 170                 175     


Glu Arg Gly Val Asn Arg Val Val Asp Glu Val Val Asp Val Arg Leu 
            180                 185                 190         


Asn Asn Arg Gly Tyr Ile Ser Asn Leu Leu Thr Lys Glu Gly Arg Thr 
        195                 200                 205             


Leu Glu Ala Asp Leu Phe Ile Asp Cys Ser Gly Met Arg Gly Leu Leu 
    210                 215                 220                 


Ile Asn Gln Ala Leu Lys Glu Pro Phe Ile Asp Met Ser Asp Tyr Leu 
225                 230                 235                 240 


Leu Cys Asp Ser Ala Val Ala Ser Ala Val Pro Asn Asp Asp Ala Arg 
                245                 250                 255     


Asp Gly Val Glu Pro Tyr Thr Ser Ser Ile Ala Met Asn Ser Gly Trp 
            260                 265                 270         


Thr Trp Lys Ile Pro Met Leu Gly Arg Phe Gly Ser Gly Tyr Val Phe 
        275                 280                 285             


Ser Ser His Phe Thr Ser Arg Asp Gln Ala Thr Ala Asp Phe Leu Lys 
    290                 295                 300                 


Leu Trp Gly Leu Ser Asp Asn Gln Pro Leu Asn Gln Ile Lys Phe Arg 
305                 310                 315                 320 


Val Gly Arg Asn Lys Arg Ala Trp Val Asn Asn Cys Val Ser Ile Gly 
                325                 330                 335     


Leu Ser Ser Cys Phe Leu Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe 
            340                 345                 350         


Ile Tyr Ala Ala Leu Tyr Gln Leu Val Lys His Phe Pro Asp Thr Ser 
        355                 360                 365             


Phe Asp Pro Arg Leu Ser Asp Ala Phe Asn Ala Glu Ile Val His Met 
    370                 375                 380                 


Phe Asp Asp Cys Arg Asp Phe Val Gln Ala His Tyr Phe Thr Thr Ser 
385                 390                 395                 400 


Arg Asp Asp Thr Pro Phe Trp Leu Ala Asn Arg His Asp Leu Arg Leu 
                405                 410                 415     


Ser Asp Ala Ile Lys Glu Lys Val Gln Arg Tyr Lys Ala Gly Leu Pro 
            420                 425                 430         


Leu Thr Thr Thr Ser Phe Asp Asp Ser Thr Tyr Tyr Glu Thr Phe Asp 
        435                 440                 445             


Tyr Glu Phe Lys Asn Phe Trp Leu Asn Gly Asn Tyr Tyr Cys Ile Phe 
    450                 455                 460                 


Ala Gly Leu Gly Met Leu Pro Asp Arg Ser Leu Pro Leu Leu Gln His 
465                 470                 475                 480 


Arg Pro Glu Ser Ile Glu Lys Ala Glu Ala Met Phe Ala Ser Ile Arg 
                485                 490                 495     


Arg Glu Ala Glu Arg Leu Arg Thr Ser Leu Pro Thr Asn Tyr Asp Tyr 
            500                 505                 510         


Leu Arg Ser Leu Arg Asp Gly Asp Ala Gly Leu Ser Arg Gly Gln Arg 
        515                 520                 525             


Gly Pro Lys Leu Ala Ala Gln Glu Ser Leu 
    530                 535             


<210>  27
<211>  1593
<212>  DNA
<213>  Lentzea areocolonigenes

<400>  27
atgtccggca agattgacaa gatcctcatc gtcggcggcg gcaccgccgg atggatggcc       60

gcgtcctatc tcggcaaggc cctgcagggc accgcggaca tcacactgct gcaggcaccc      120

gacatcccga cgctcggggt cggcgaggcc acgatcccca atctgcagac ggcgttcttc      180

gacttcctcg gaatccccga ggacgagtgg atgcgggagt gcaacgcgag ctacaaggtc      240

gccatcaagt tcatcaactg gcgcaccgcg ggcgagggga cgtccgaggc ccgcgagctc      300

gacggagggc ccgaccactt ctaccactcc ttcggtctgc tcaagtacca cgagcagatt      360

ccgctgtcgc actactggtt cgaccgttcg taccggggga agaccgtcga gccgttcgac      420

tacgcctgct acaaggaacc cgtcatcctc gacgccaaca ggtcaccgcg caggctcgac      480

ggttccaagg tgacgaacta cgcgtggcac ttcgacgcgc acctcgtcgc cgacttcctg      540

cgccggttcg ccaccgagaa gctcggcgtg cgccacgtcg aggaccgcgt cgagcacgtc      600

cagcgcgacg ccaacggcaa catcgagtcg gttcgcacgg caacggggcg tgtcttcgat      660

gccgacctct tcgtcgactg ctcgggcttc cgcgggctgc tgatcaacaa ggcgatggag      720

gagcccttcc tcgacatgag cgatcacctg ctcaacgaca gcgccgtcgc cacccaggtg      780

ccgcacgacg acgacgcgaa cggtgtggaa ccgttcacct cggcgatcgc catgaagtcg      840

ggctggacgt ggaagatccc gatgctcggc aggttcggca ccgggtacgt ctactcgagc      900

cggttcgcca ccgaggacga ggcggtgcgc gagttctgcg agatgtggca cctcgacccg      960

gagacccagc ccctcaacag gatccggttc cgggtcggcc gcaaccggcg cgcgtgggtc     1020

ggcaactgcg tcagcatcgg cacgtcgtcg tgcttcgtgg aaccactgga gtcgacgggc     1080

atctacttcg tctacgccgc gctgtaccag ctggtgaagc acttccccga caagagcctc     1140

aaccccgtgc tgaccgccag gttcaaccgc gagatcgaga cgatgttcga cgacacgcgc     1200

gacttcatcc aggcgcactt ctacttctcg ccgcgcacgg acaccccgtt ctggagggcc     1260

aacaaggagc tgcgcctggc ggacggcatg caggagaaga tcgacatgta ccgcgcgggc     1320

atggcgatca acgcgcccgc gtccgacgac gcccagctct actacggcaa cttcgaggag     1380

gagttccgca acttctggaa caacagcaac tactactgcg tgctggccgg cctcggtctg     1440

gtgcccgacg caccctcacc acgcctggcg cacatgccac aggcgacgga gtcggtggac     1500

gaggtcttcg gcgccgtcaa ggaccggcag cggaacctgc tcgagaccct gccgagcctc     1560

cacgagttcc tgaggcaaca gcacggccgc tga                                  1593


<210>  28
<211>  530
<212>  PRT
<213>  Lentzea areocolonigenes

<400>  28

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Ile Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Ser Phe Gly 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Ser Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Asn Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Leu Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Ala Ile Asn Ala Pro Ala Ser 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Tyr Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Phe Trp Asn Asn Ser Asn Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Gln Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Arg Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  29
<211>  516
<212>  PRT
<213>  Streptomyces albus

<400>  29

Met Leu Asn Asn Val Val Ile Val Gly Gly Gly Thr Ala Gly Trp Met 
1               5                   10                  15      


Thr Ala Ser Tyr Phe Lys Ala Ala Phe Gly Glu Arg Ile Asn Ile Thr 
            20                  25                  30          


Leu Val Glu Ser Gly Asn Ile Gly Ala Val Gly Val Gly Glu Ala Thr 
        35                  40                  45              


Phe Ser Asp Ile Arg His Phe Phe Asp Phe Leu Gly Leu Lys Glu Lys 
    50                  55                  60                  


Asp Trp Met Pro Ala Cys Asn Ala Thr Tyr Lys Leu Ala Val Arg Phe 
65                  70                  75                  80  


Glu Asn Trp Arg Glu Glu Gly His Tyr Phe Tyr His Pro Phe Glu Gln 
                85                  90                  95      


Met Arg Ser Val Asn Gly Phe Pro Leu Ala Asp Trp Trp Leu Arg Glu 
            100                 105                 110         


Lys Pro Thr Asp Arg Phe Asp Lys Asp Cys Phe Val Met Pro Ser Ile 
        115                 120                 125             


Ile Asp Ala Gly Leu Ser Pro Arg His Leu Asp Gly Ser Leu Ile Asp 
    130                 135                 140                 


Gln Pro Phe Val Glu Gly Ala Glu Glu Met Gln Gly Leu Thr Met Ser 
145                 150                 155                 160 


Glu His Gln Gly Lys Thr Gln Phe Pro Tyr Ala Tyr Gln Phe Glu Ala 
                165                 170                 175     


Ala Leu Leu Ala Lys Tyr Leu Thr Thr Tyr Ser Val Glu Arg Gly Val 
            180                 185                 190         


Lys His Ile Val Asp Asp Val Gln Gln Val Asn Leu Asp Glu Arg Gly 
        195                 200                 205             


Trp Ile Arg Asn Val Thr Thr Ala Glu His Gly Glu Ile Gly Gly Asp 
    210                 215                 220                 


Leu Phe Ile Asp Cys Thr Gly Phe Arg Gly Leu Leu Leu Asn Lys Ala 
225                 230                 235                 240 


Leu Glu Glu Pro Phe Ile Ser Phe Gln Asp Thr Leu Pro Asn Asp Ser 
                245                 250                 255     


Ala Val Ala Leu Gln Val Pro Met Asp Met Glu Arg Arg Gly Ile Leu 
            260                 265                 270         


Pro Cys Thr Thr Ala Thr Ala Gln Asp Ala Gly Trp Ile Trp Thr Ile 
        275                 280                 285             


Pro Leu Met Gly Arg Val Gly Thr Gly Tyr Val Tyr Ala Lys Asp Tyr 
    290                 295                 300                 


Ile Ser Pro Glu Glu Ala Glu Arg Thr Leu Arg Glu Phe Val Gly Pro 
305                 310                 315                 320 


Ala Ala Ala Asp Ala Glu Ala Asn His Ile Lys Met Arg Val Gly Arg 
                325                 330                 335     


Ser Glu Asn Ser Trp Val Lys Asn Cys Val Ala Ile Gly Leu Ser Ser 
            340                 345                 350         


Gly Phe Val Glu Pro Leu Glu Ser Thr Gly Ile Phe Phe Ile His His 
        355                 360                 365             


Ala Ile Glu Gln Leu Ala Lys Asn Phe Pro Gly Glu Asp Trp Asn Pro 
    370                 375                 380                 


Val Gln Arg Asn Leu Tyr Asn Asp Ser Val Ala His Val Met Asp Gly 
385                 390                 395                 400 


Val Arg Glu Phe Leu Val Leu His Tyr Val Ala Ala Lys Arg Ser Asp 
                405                 410                 415     


Thr Gln Tyr Trp Arg Asp Thr Lys Thr Arg Lys Ile Pro Asp Ala Leu 
            420                 425                 430         


Ala Glu Arg Ile Glu Lys Trp Lys Thr Gln Leu Pro Asp Thr Glu Thr 
        435                 440                 445             


Val Phe Pro Tyr Tyr His Gly Leu Pro Pro Tyr Ser Tyr His Cys Val 
    450                 455                 460                 


Leu Leu Gly Met Gly Gly Ile Asp Val Lys Pro Ser Pro Ala Leu Ala 
465                 470                 475                 480 


Leu Gly Asp Ser Ala Ala Ala Glu Arg Glu Phe Ala Glu Ile Arg Glu 
                485                 490                 495     


Lys Thr Arg His Leu Thr Ser Val Leu Pro Lys Ala Tyr Asp Tyr Phe 
            500                 505                 510         


Ser Arg Met Arg 
        515     


<210>  30
<211>  530
<212>  PRT
<213>  Lentzea aerocologinenes

<400>  30

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Ile Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Ser Phe Gly 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Ser Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Asn Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Leu Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Ala Ile Asn Ala Pro Ala Ser 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Trp Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Phe Trp Asn Asn Ser Asn Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Gln Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Arg Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  31
<211>  530
<212>  PRT
<213>  Lentzea aerocologinenes

<400>  31

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Ile Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Ser Phe Gly 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Ser Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Asn Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Leu Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Ala Ile Asn Ala Pro Ala Ser 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Tyr Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Phe Trp Asn Asn Ser Ser Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Gln Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Arg Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  32
<211>  530
<212>  PRT
<213>  Lentzea aerocologinenes

<400>  32

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Met Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Pro Phe Gly 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Leu Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Ser Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Phe Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Ala Ile Asn Ala Pro Ala Pro 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Trp Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Leu Trp Asn Asn Ser Ser Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Arg Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Gln Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  33
<211>  530
<212>  PRT
<213>  Lentzea aerocologinenes

<400>  33

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr His Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Ser Phe Gly 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Ser Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Asn Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Phe Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Ala Ile Asn Ala Pro Ala Ser 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Tyr Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Cys Trp Asn Asn Ser Ser Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Arg Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Gln Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  34
<211>  530
<212>  PRT
<213>  Lentzea aerocologinenes

<400>  34

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Ile Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Ser Phe Ser 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Ser Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Asn Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Leu Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Ala Ile Asn Ala Pro Ala Ser 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Tyr Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Phe Trp Asn Asn Ser Ser Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Gln Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Arg Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  35
<211>  530
<212>  PRT
<213>  Lentzea aerocologinenes

<400>  35

Met Ser Gly Lys Ile Asp Lys Ile Leu Ile Val Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Trp Met Ala Ala Ser Tyr Leu Gly Lys Ala Leu Gln Gly Thr Ala 
            20                  25                  30          


Asp Ile Thr Leu Leu Gln Ala Pro Asp Ile Pro Thr Leu Gly Val Gly 
        35                  40                  45              


Glu Ala Thr Ile Pro Asn Leu Gln Thr Ala Phe Phe Asp Phe Leu Gly 
    50                  55                  60                  


Ile Pro Glu Asp Glu Trp Met Arg Glu Cys Asn Ala Ser Tyr Lys Val 
65                  70                  75                  80  


Ala Ile Lys Phe Ile Asn Trp Arg Thr Ala Gly Glu Gly Thr Ser Glu 
                85                  90                  95      


Ala Arg Glu Leu Asp Gly Gly Pro Asp His Phe Tyr His Ser Phe Gly 
            100                 105                 110         


Leu Leu Lys Tyr His Glu Gln Ile Pro Leu Ser His Tyr Trp Phe Asp 
        115                 120                 125             


Arg Ser Tyr Arg Gly Lys Thr Val Glu Pro Phe Asp Tyr Ala Cys Tyr 
    130                 135                 140                 


Lys Glu Pro Val Ile Leu Asp Ala Asn Arg Ser Pro Arg Arg Leu Asp 
145                 150                 155                 160 


Gly Ser Lys Val Thr Asn Tyr Ala Trp His Phe Asp Ala His Leu Val 
                165                 170                 175     


Ala Asp Phe Leu Arg Arg Phe Ala Thr Glu Lys Leu Gly Val Arg His 
            180                 185                 190         


Val Glu Asp Arg Val Glu His Val Gln Arg Asp Ala Asn Gly Asn Ile 
        195                 200                 205             


Glu Ser Val Arg Thr Ala Thr Gly Arg Val Phe Asp Ala Asp Leu Phe 
    210                 215                 220                 


Val Asp Cys Ser Gly Phe Arg Gly Leu Leu Ile Asn Lys Ala Met Glu 
225                 230                 235                 240 


Glu Pro Phe Leu Asp Met Ser Asp His Leu Leu Asn Asp Ser Ala Val 
                245                 250                 255     


Ala Thr Gln Val Pro His Asp Asp Asp Ala Asn Gly Val Glu Pro Phe 
            260                 265                 270         


Thr Ser Ala Ile Ala Met Lys Ser Gly Trp Thr Trp Lys Ile Pro Met 
        275                 280                 285             


Leu Gly Arg Phe Gly Thr Gly Tyr Val Tyr Ser Ser Arg Phe Ala Thr 
    290                 295                 300                 


Glu Asp Glu Ala Val Arg Glu Phe Cys Glu Met Trp His Leu Asp Pro 
305                 310                 315                 320 


Glu Thr Gln Pro Leu Asn Arg Ile Arg Phe Arg Val Gly Arg Asn Arg 
                325                 330                 335     


Arg Ala Trp Val Gly Asn Cys Val Ser Ile Gly Thr Ser Ser Cys Phe 
            340                 345                 350         


Val Glu Pro Leu Glu Ser Thr Gly Ile Tyr Phe Val Tyr Ala Ala Leu 
        355                 360                 365             


Tyr Gln Leu Val Lys His Phe Pro Asp Lys Ser Leu Asn Pro Val Leu 
    370                 375                 380                 


Thr Ala Arg Phe Asn Arg Glu Ile Glu Thr Met Phe Asp Asp Thr Arg 
385                 390                 395                 400 


Asp Phe Ile Gln Ala His Phe Tyr Phe Ser Pro Arg Thr Asp Thr Pro 
                405                 410                 415     


Phe Trp Arg Ala Asn Lys Glu Leu Arg Leu Ala Asp Gly Met Gln Glu 
            420                 425                 430         


Lys Ile Asp Met Tyr Arg Ala Gly Met Val Ile Asn Ala Pro Ala Ser 
        435                 440                 445             


Asp Asp Ala Gln Leu Tyr Tyr Gly Asn Phe Glu Glu Glu Phe Arg Asn 
    450                 455                 460                 


Phe Trp Asn Asn Ser Asn Tyr Tyr Cys Val Leu Ala Gly Leu Gly Leu 
465                 470                 475                 480 


Val Pro Asp Ala Pro Ser Pro Arg Leu Ala His Met Pro Gln Ala Thr 
                485                 490                 495     


Glu Ser Val Asp Glu Val Phe Gly Ala Val Lys Asp Arg Gln Arg Asn 
            500                 505                 510         


Leu Leu Glu Thr Leu Pro Ser Leu His Glu Phe Leu Arg Gln Gln His 
        515                 520                 525             


Gly Arg 
    530 


<210>  36
<211>  1446
<212>  DNA
<213>  Bacillus atrophaeus

<400>  36
atgatgtctg aaaatttgca attgtcagct gaagaaatga gacaattggg ttaccaagca       60

gttgatttga tcatcgatca catgaaccat ttgaagtcta agccagtttc agaaacaatc      120

gattctgata tcttgagaaa taagttgact gaatctatcc cagaaaatgg ttcagatcca      180

aaggaattgt tgcatttctt gaacagaaac gtttttaatc aaattacaca tgttgatcat      240

ccacatttct tggcttttgt tccaggtcca aataattacg ttggtgttgt tgcagatttc      300

ttggcttctg gttttaatgt ttttccaact gcatggattg ctggtgcagg tgctgaacaa      360

atcgaattga ctacaattaa ttggttgaaa tctatgttgg gttttccaga ttcagctgaa      420

ggtttatttg tttctggtgg ttcaatggca aatttgacag ctttgactgt tgcaagacag      480

gctaagttga acaacgatat cgaaaatgct gttgtttact tctctgatca aacacatttc      540

tcagttgata gagcattgaa ggttttaggt tttaaacatc atcaaatctg tagaatcgaa      600

acagatgaac atttgagaat ctctgtttca gctttgaaga aacaaattaa agaagataga      660

actaagggta aaaagccatt ctgtgttatt gcaaatgctg gtactacaaa ttgtggtgct      720

gttgattctt tgaacgaatt agcagatttg tgtaacgatg aagatgtttg gttgcatgct      780

gatggttctt atggtgctcc agctatcttg tctgaaaagg gttcagctat gttgcaaggt      840

attcatagag cagattcttt gactttagat ccacataagt ggttgttcca accatacgat      900

gttggttgtg ttttgatcag aaactctcaa tatttgtcaa agacttttag aatgatgcca      960

gaatacatca aggattcaga aactaacgtt gaaggtgaaa ttaatttcgg tgaatgtggt     1020

atcgaattgt caagaagatt cagagctttg aaggtttggt tgtcttttaa agttttcggt     1080

gttgctgctt ttagacaagc aatcgatcat ggtatcatgt tagcagaaca agttgaagca     1140

tttttgggta aagcaaaaga ttgggaagtt gttacaccag ctcaattggg tatcgttact     1200

tttagataca ttccatctga attggcatca acagatacta ttaatgaaat taataagaaa     1260

ttggttaagg aaatcacaca tagaggtttc gctatgttat ctactacaga attgaaggaa     1320

aaggttgtta ttagattgtg ttcaattaat ccaagaacta caactgaaga aatgttgcaa     1380

atcatgatga agattaaagc attggctgaa gaagtttcta tttcataccc atgtgttgct     1440

gaataa                                                                1446


<210>  37
<211>  481
<212>  PRT
<213>  Bacillus atrophaeus

<400>  37

Met Met Ser Glu Asn Leu Gln Leu Ser Ala Glu Glu Met Arg Gln Leu 
1               5                   10                  15      


Gly Tyr Gln Ala Val Asp Leu Ile Ile Asp His Met Asn His Leu Lys 
            20                  25                  30          


Ser Lys Pro Val Ser Glu Thr Ile Asp Ser Asp Ile Leu Arg Asn Lys 
        35                  40                  45              


Leu Thr Glu Ser Ile Pro Glu Asn Gly Ser Asp Pro Lys Glu Leu Leu 
    50                  55                  60                  


His Phe Leu Asn Arg Asn Val Phe Asn Gln Ile Thr His Val Asp His 
65                  70                  75                  80  


Pro His Phe Leu Ala Phe Val Pro Gly Pro Asn Asn Tyr Val Gly Val 
                85                  90                  95      


Val Ala Asp Phe Leu Ala Ser Gly Phe Asn Val Phe Pro Thr Ala Trp 
            100                 105                 110         


Ile Ala Gly Ala Gly Ala Glu Gln Ile Glu Leu Thr Thr Ile Asn Trp 
        115                 120                 125             


Leu Lys Ser Met Leu Gly Phe Pro Asp Ser Ala Glu Gly Leu Phe Val 
    130                 135                 140                 


Ser Gly Gly Ser Met Ala Asn Leu Thr Ala Leu Thr Val Ala Arg Gln 
145                 150                 155                 160 


Ala Lys Leu Asn Asn Asp Ile Glu Asn Ala Val Val Tyr Phe Ser Asp 
                165                 170                 175     


Gln Thr His Phe Ser Val Asp Arg Ala Leu Lys Val Leu Gly Phe Lys 
            180                 185                 190         


His His Gln Ile Cys Arg Ile Glu Thr Asp Glu His Leu Arg Ile Ser 
        195                 200                 205             


Val Ser Ala Leu Lys Lys Gln Ile Lys Glu Asp Arg Thr Lys Gly Lys 
    210                 215                 220                 


Lys Pro Phe Cys Val Ile Ala Asn Ala Gly Thr Thr Asn Cys Gly Ala 
225                 230                 235                 240 


Val Asp Ser Leu Asn Glu Leu Ala Asp Leu Cys Asn Asp Glu Asp Val 
                245                 250                 255     


Trp Leu His Ala Asp Gly Ser Tyr Gly Ala Pro Ala Ile Leu Ser Glu 
            260                 265                 270         


Lys Gly Ser Ala Met Leu Gln Gly Ile His Arg Ala Asp Ser Leu Thr 
        275                 280                 285             


Leu Asp Pro His Lys Trp Leu Phe Gln Pro Tyr Asp Val Gly Cys Val 
    290                 295                 300                 


Leu Ile Arg Asn Ser Gln Tyr Leu Ser Lys Thr Phe Arg Met Met Pro 
305                 310                 315                 320 


Glu Tyr Ile Lys Asp Ser Glu Thr Asn Val Glu Gly Glu Ile Asn Phe 
                325                 330                 335     


Gly Glu Cys Gly Ile Glu Leu Ser Arg Arg Phe Arg Ala Leu Lys Val 
            340                 345                 350         


Trp Leu Ser Phe Lys Val Phe Gly Val Ala Ala Phe Arg Gln Ala Ile 
        355                 360                 365             


Asp His Gly Ile Met Leu Ala Glu Gln Val Glu Ala Phe Leu Gly Lys 
    370                 375                 380                 


Ala Lys Asp Trp Glu Val Val Thr Pro Ala Gln Leu Gly Ile Val Thr 
385                 390                 395                 400 


Phe Arg Tyr Ile Pro Ser Glu Leu Ala Ser Thr Asp Thr Ile Asn Glu 
                405                 410                 415     


Ile Asn Lys Lys Leu Val Lys Glu Ile Thr His Arg Gly Phe Ala Met 
            420                 425                 430         


Leu Ser Thr Thr Glu Leu Lys Glu Lys Val Val Ile Arg Leu Cys Ser 
        435                 440                 445             


Ile Asn Pro Arg Thr Thr Thr Glu Glu Met Leu Gln Ile Met Met Lys 
    450                 455                 460                 


Ile Lys Ala Leu Ala Glu Glu Val Ser Ile Ser Tyr Pro Cys Val Ala 
465                 470                 475                 480 


Glu 
    


<210>  38
<211>  1473
<212>  DNA
<213>  Ruminococcus gnayus

<400>  38
atgtctcaag tgatcaaaaa aaagagaaac actttcatga tcggtaccga atatatattg       60

aactctaccc aattagaaga ggctattaaa tctttcgtcc atgatttctg tgccgaaaag      120

cacgaaattc acgaccaacc agttgtcgtt gaagctaagg aacaccaaga agataagatt      180

aagcaaatca aaattccaga aaagggtcgt ccagtcaatg aagttgtttc tgaaatgatg      240

aacgaagtct acagatacag aggtgatgcc aaccatccaa gattcttctc tttcgttcca      300

ggtccagctt cctctgtctc ctggttgggt gacatcatga cttctgctta caacatccac      360

gctggtggtt ctaaattggc cccaatggtt aactgtatcg aacaagaagt cttgaaatgg      420

ctcgcaaagc aagttggttt caccgaaaac cctggtggtg ttttcgtttc cggtggttct      480

atggctaaca ttactgcttt gacagccgct agagacaaca agcttaccga tattaacttg      540

cacttgggta ctgcttacat ttccgaccaa acccactctt cagttgctaa gggtttacgt      600

atcattggta tcactgactc cagaatcaga agaattccaa ctaactccca cttccaaatg      660

gacaccacta agttggaaga agctatcgaa accgacaaga agtccggtta catcccattt      720

gttgttatcg gtactgccgg taccaccaac actggttcca ttgacccatt gactgaaatt      780

tccgctttgt gtaagaagca tgacatgtgg ttccacattg atggtgccta cggtgcttca      840

gttttgttgt ctccaaagta caagtctttg ttaacaggta ccggtttggc tgactctatc      900

tcttgggatg ctcacaagtg gttatttcaa acttacggtt gtgctatggt tttggtcaag      960

gatattagaa acttgtttca ttccttccac gtcaatccag aatacttgaa ggatctggaa     1020

aacgacatcg ataacgttaa cacctgggac atcggcatgg aattgaccag accagccaga     1080

ggtttgaagt tgtggttgac tttgcaagtt ctaggttctg atcttattgg ttctgccatt     1140

gaacacggtt tccaattggc tgtctgggct gaagaagcct tgaatccaaa gaaggactgg     1200

gaaattgtct ctcctgctca aatggctatg atcaacttca gatatgctcc aaaggacttg     1260

accaaggaag aacaagatat cttgaacgaa aagatctctc accgtatttt ggaatccggt     1320

tacgctgcta tcttcactac cgtcctaaac ggtaagactg tcttgagaat ctgcgctatt     1380

cacccagaag ctactcaaga agacatgcaa cacaccattg atttgttgga ccaatacggt     1440

agagaaatct acactgaaat gaagaaggct tag                                  1473


<210>  39
<211>  490
<212>  PRT
<213>  Ruminococcus gnayus

<400>  39

Met Ser Gln Val Ile Lys Lys Lys Arg Asn Thr Phe Met Ile Gly Thr 
1               5                   10                  15      


Glu Tyr Ile Leu Asn Ser Thr Gln Leu Glu Glu Ala Ile Lys Ser Phe 
            20                  25                  30          


Val His Asp Phe Cys Ala Glu Lys His Glu Ile His Asp Gln Pro Val 
        35                  40                  45              


Val Val Glu Ala Lys Glu His Gln Glu Asp Lys Ile Lys Gln Ile Lys 
    50                  55                  60                  


Ile Pro Glu Lys Gly Arg Pro Val Asn Glu Val Val Ser Glu Met Met 
65                  70                  75                  80  


Asn Glu Val Tyr Arg Tyr Arg Gly Asp Ala Asn His Pro Arg Phe Phe 
                85                  90                  95      


Ser Phe Val Pro Gly Pro Ala Ser Ser Val Ser Trp Leu Gly Asp Ile 
            100                 105                 110         


Met Thr Ser Ala Tyr Asn Ile His Ala Gly Gly Ser Lys Leu Ala Pro 
        115                 120                 125             


Met Val Asn Cys Ile Glu Gln Glu Val Leu Lys Trp Leu Ala Lys Gln 
    130                 135                 140                 


Val Gly Phe Thr Glu Asn Pro Gly Gly Val Phe Val Ser Gly Gly Ser 
145                 150                 155                 160 


Met Ala Asn Ile Thr Ala Leu Thr Ala Ala Arg Asp Asn Lys Leu Thr 
                165                 170                 175     


Asp Ile Asn Leu His Leu Gly Thr Ala Tyr Ile Ser Asp Gln Thr His 
            180                 185                 190         


Ser Ser Val Ala Lys Gly Leu Arg Ile Ile Gly Ile Thr Asp Ser Arg 
        195                 200                 205             


Ile Arg Arg Ile Pro Thr Asn Ser His Phe Gln Met Asp Thr Thr Lys 
    210                 215                 220                 


Leu Glu Glu Ala Ile Glu Thr Asp Lys Lys Ser Gly Tyr Ile Pro Phe 
225                 230                 235                 240 


Val Val Ile Gly Thr Ala Gly Thr Thr Asn Thr Gly Ser Ile Asp Pro 
                245                 250                 255     


Leu Thr Glu Ile Ser Ala Leu Cys Lys Lys His Asp Met Trp Phe His 
            260                 265                 270         


Ile Asp Gly Ala Tyr Gly Ala Ser Val Leu Leu Ser Pro Lys Tyr Lys 
        275                 280                 285             


Ser Leu Leu Thr Gly Thr Gly Leu Ala Asp Ser Ile Ser Trp Asp Ala 
    290                 295                 300                 


His Lys Trp Leu Phe Gln Thr Tyr Gly Cys Ala Met Val Leu Val Lys 
305                 310                 315                 320 


Asp Ile Arg Asn Leu Phe His Ser Phe His Val Asn Pro Glu Tyr Leu 
                325                 330                 335     


Lys Asp Leu Glu Asn Asp Ile Asp Asn Val Asn Thr Trp Asp Ile Gly 
            340                 345                 350         


Met Glu Leu Thr Arg Pro Ala Arg Gly Leu Lys Leu Trp Leu Thr Leu 
        355                 360                 365             


Gln Val Leu Gly Ser Asp Leu Ile Gly Ser Ala Ile Glu His Gly Phe 
    370                 375                 380                 


Gln Leu Ala Val Trp Ala Glu Glu Ala Leu Asn Pro Lys Lys Asp Trp 
385                 390                 395                 400 


Glu Ile Val Ser Pro Ala Gln Met Ala Met Ile Asn Phe Arg Tyr Ala 
                405                 410                 415     


Pro Lys Asp Leu Thr Lys Glu Glu Gln Asp Ile Leu Asn Glu Lys Ile 
            420                 425                 430         


Ser His Arg Ile Leu Glu Ser Gly Tyr Ala Ala Ile Phe Thr Thr Val 
        435                 440                 445             


Leu Asn Gly Lys Thr Val Leu Arg Ile Cys Ala Ile His Pro Glu Ala 
    450                 455                 460                 


Thr Gln Glu Asp Met Gln His Thr Ile Asp Leu Leu Asp Gln Tyr Gly 
465                 470                 475                 480 


Arg Glu Ile Tyr Thr Glu Met Lys Lys Ala 
                485                 490 


<210>  40
<211>  1482
<212>  DNA
<213>  Streptomyces griseofuscus

<400>  40
atgaagccag ctgaagctaa accacctcac atggaccatg atactttcag atccttgggt       60

caccaagcta ttgactggat tgctgattac tggcaacact tggctgacag accagttgct      120

ccattggttg aaccaggtac tgttagagcc caattgccta ccactccacc agagtacggt      180

gaagacttcc cagctttgtt atctgacttg gaaagaattg tcttgccagg cttgttgcac      240

tggcaacacc caagattctt cggttacttc ccagctaacg cttccggtcc agccgtttta      300

gctgaattat tatctgctgg tctaggtgtc caaggtatga actggaacac ttctccagct      360

tgtaccgaag ttgaacaaca aatgttggac tggttcgttc atttgttagg gttgccagaa      420

cacttcagag gtggtggtgt tatccaagac actgcctcct ccgccgtttt ggtcgctcta      480

ttgactgctt tgcacagagc ttctgctggt agaaccagag atcacggtac tggtgaatgt      540

ggttacaggg tttacctaac cgctgaaact cactccgctg ctagaaaggc tgccgtcatc      600

accggtttgg gtttgcgtgc tgtttgtgaa gtcgcaactg atgctgacgg tgctatggat      660

gccgctgact tggccgctcg tattcaagcc gatttggctg ccggtttgac cccattgatg      720

gttgttgcta cccgtggtac cacctctgat ttgtccttcg atccattgga agacatcggt      780

ccagtctgta gaagacatgg tgtctggtta cacgttgacg ctgcttatgc tggtgttgct      840

gcagtgtgcg atgaattgca ttgggttaat gatggtgtta gatacgctga ttcttactgt      900

actaacccac acaagtggtt gttgaccaac ttcgactgtg atttattatg ggttgccgac      960

ccagaagctt tggtcaacgc tttgtccgtt ttgcctgctt acttgagaaa cccagcttct     1020

gaatcaggta gagttactga ctacagacac tggcaagttc cattgggcag aagattcaga     1080

gccttgaagt tgtggtctgt cttaagatgg tacggtgccg aaggtttgag atctcacatc     1140

agaactggtg tcagacacgc cagattgttc gctgacctgg tcagagaaga tgaccgtttc     1200

accttgttgg cgccagctac tttgggtttg gtcactttcc gtcacgctgg ttctgacacc     1260

gacaacagaa acttgttgca cgctatcaac gccgaaggta caactttttt aactcatagt     1320

gaaaagaacg gtaccttttt cttgagattt gctaccggtg gtacccacac tgaagaccat     1380

cacgtccacg aagcttggag agctgtccaa aatgccgtcc aaaacgccgt cccaagagcc     1440

caacatgcca ccgatggtac tgccgatgct ttgaacggtt aa                        1482


<210>  41
<211>  493
<212>  PRT
<213>  Streptomyces griseofuscus

<400>  41

Met Lys Pro Ala Glu Ala Lys Pro Pro His Met Asp His Asp Thr Phe 
1               5                   10                  15      


Arg Ser Leu Gly His Gln Ala Ile Asp Trp Ile Ala Asp Tyr Trp Gln 
            20                  25                  30          


His Leu Ala Asp Arg Pro Val Ala Pro Leu Val Glu Pro Gly Thr Val 
        35                  40                  45              


Arg Ala Gln Leu Pro Thr Thr Pro Pro Glu Tyr Gly Glu Asp Phe Pro 
    50                  55                  60                  


Ala Leu Leu Ser Asp Leu Glu Arg Ile Val Leu Pro Gly Leu Leu His 
65                  70                  75                  80  


Trp Gln His Pro Arg Phe Phe Gly Tyr Phe Pro Ala Asn Ala Ser Gly 
                85                  90                  95      


Pro Ala Val Leu Ala Glu Leu Leu Ser Ala Gly Leu Gly Val Gln Gly 
            100                 105                 110         


Met Asn Trp Asn Thr Ser Pro Ala Cys Thr Glu Val Glu Gln Gln Met 
        115                 120                 125             


Leu Asp Trp Phe Val His Leu Leu Gly Leu Pro Glu His Phe Arg Gly 
    130                 135                 140                 


Gly Gly Val Ile Gln Asp Thr Ala Ser Ser Ala Val Leu Val Ala Leu 
145                 150                 155                 160 


Leu Thr Ala Leu His Arg Ala Ser Ala Gly Arg Thr Arg Asp His Gly 
                165                 170                 175     


Thr Gly Glu Cys Gly Tyr Arg Val Tyr Leu Thr Ala Glu Thr His Ser 
            180                 185                 190         


Ala Ala Arg Lys Ala Ala Val Ile Thr Gly Leu Gly Leu Arg Ala Val 
        195                 200                 205             


Cys Glu Val Ala Thr Asp Ala Asp Gly Ala Met Asp Ala Ala Asp Leu 
    210                 215                 220                 


Ala Ala Arg Ile Gln Ala Asp Leu Ala Ala Gly Leu Thr Pro Leu Met 
225                 230                 235                 240 


Val Val Ala Thr Arg Gly Thr Thr Ser Asp Leu Ser Phe Asp Pro Leu 
                245                 250                 255     


Glu Asp Ile Gly Pro Val Cys Arg Arg His Gly Val Trp Leu His Val 
            260                 265                 270         


Asp Ala Ala Tyr Ala Gly Val Ala Ala Val Cys Asp Glu Leu His Trp 
        275                 280                 285             


Val Asn Asp Gly Val Arg Tyr Ala Asp Ser Tyr Cys Thr Asn Pro His 
    290                 295                 300                 


Lys Trp Leu Leu Thr Asn Phe Asp Cys Asp Leu Leu Trp Val Ala Asp 
305                 310                 315                 320 


Pro Glu Ala Leu Val Asn Ala Leu Ser Val Leu Pro Ala Tyr Leu Arg 
                325                 330                 335     


Asn Pro Ala Ser Glu Ser Gly Arg Val Thr Asp Tyr Arg His Trp Gln 
            340                 345                 350         


Val Pro Leu Gly Arg Arg Phe Arg Ala Leu Lys Leu Trp Ser Val Leu 
        355                 360                 365             


Arg Trp Tyr Gly Ala Glu Gly Leu Arg Ser His Ile Arg Thr Gly Val 
    370                 375                 380                 


Arg His Ala Arg Leu Phe Ala Asp Leu Val Arg Glu Asp Asp Arg Phe 
385                 390                 395                 400 


Thr Leu Leu Ala Pro Ala Thr Leu Gly Leu Val Thr Phe Arg His Ala 
                405                 410                 415     


Gly Ser Asp Thr Asp Asn Arg Asn Leu Leu His Ala Ile Asn Ala Glu 
            420                 425                 430         


Gly Thr Thr Phe Leu Thr His Ser Glu Lys Asn Gly Thr Phe Phe Leu 
        435                 440                 445             


Arg Phe Ala Thr Gly Gly Thr His Thr Glu Asp His His Val His Glu 
    450                 455                 460                 


Ala Trp Arg Ala Val Gln Asn Ala Val Gln Asn Ala Val Pro Arg Ala 
465                 470                 475                 480 


Gln His Ala Thr Asp Gly Thr Ala Asp Ala Leu Asn Gly 
                485                 490             


<210>  42
<211>  1482
<212>  DNA
<213>  Ceriporiopsis subvermispora

<400>  42
atggatattg aagcttttag aaaagcaggt taccaagcta tcgatagaat ttgtgactac       60

tactactctt tgcaaaatag accagttgtt ccatcagttc aaccaggtta tttgttagat      120

gcattaccag attctccacc agaacaaggt gaagatttca ctgttattgc tgatgattac      180

caaaagtaca tcttgccagg tttgacacat tggcaacatc catctttctt tgcatacttt      240

ccaacagctt gtacttttga aggtattttg ggtgacttgt attctacatc aactgcaaat      300

ccaggtttta attggttggc ttctccagca tgtactgaat tagaaatggt tgttatggat      360

tggtctgcta agttgttagg tttgtcagaa catttcttgc attcttcagg taaaggtggt      420

ggtgttattc aaactacagc atcagaattg gctttagttg ttgttgttgc tgcaagagaa      480

agatacttga gaattcatcc agatgctaag gcagatgaat tggttatata tactacaact      540

caaacacatt ctttgggtgt taaagctggt ttagtttttg gtatggaatg tagagcattg      600

gaagttaaag ctgaagatgc ttacgcatta agaggtgcaa ctttgaagtc agctttagaa      660

gaagatgaaa agagaggtaa aagacctttt attttggttg caacagttgg tacaacttct      720

tcaggtgcta ttgatagatt ggatgaaatt ggtcaagttt ctgaagatta tccatcatta      780

tggattcatg ttgatgctgc atgggcaggt gttactttgg cttgtccaga atacagaggt      840

acagctcaat tagaaaacat caacgcttat gcaacatctt tcggtactaa cttccataag      900

tggggtttgg ttaactttga tgctgcattg ttgtgggtta aggatagaaa ggatttgaca      960

gatgctttag atgttactcc agaattcttg agaacaaaac aaggtgacgc tggtgcagtt     1020

gttgatttta gaaattggca tttgggtttg ggtagaagat tcagatcttt gaaggtttgg     1080

ttcgttttga gatcatacgg tgttgaaggt tttagaaact acatcagaca aggtattaaa     1140

ttgaatgaac attttacttc tttaattaga gcttctttgg atttttcatt agttacagca     1200

ccatcattcg ctttgacagt ttttagattg actccagctg gtgcatcttt gactggttca     1260

gaattgaacg aattaaacag agctttctac gcaagattat cttcaagaca tgatatcatg     1320

ttgacacaaa ctgttttgaa cggtgttttc tgtatcagat ttgcagttgg tgctgcaaga     1380

actcaacaag aacatattga tacagcttgg gatttgttac aacaagaagg tgctgttgca     1440

gttcaagaat acatgcaaaa gatttctaag gatgttcaat aa                        1482


<210>  43
<211>  493
<212>  PRT
<213>  Ceriporiopsis subvermispora

<400>  43

Met Asp Ile Glu Ala Phe Arg Lys Ala Gly Tyr Gln Ala Ile Asp Arg 
1               5                   10                  15      


Ile Cys Asp Tyr Tyr Tyr Ser Leu Gln Asn Arg Pro Val Val Pro Ser 
            20                  25                  30          


Val Gln Pro Gly Tyr Leu Leu Asp Ala Leu Pro Asp Ser Pro Pro Glu 
        35                  40                  45              


Gln Gly Glu Asp Phe Thr Val Ile Ala Asp Asp Tyr Gln Lys Tyr Ile 
    50                  55                  60                  


Leu Pro Gly Leu Thr His Trp Gln His Pro Ser Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Cys Thr Phe Glu Gly Ile Leu Gly Asp Leu Tyr Ser Thr 
                85                  90                  95      


Ser Thr Ala Asn Pro Gly Phe Asn Trp Leu Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Met Val Val Met Asp Trp Ser Ala Lys Leu Leu Gly Leu 
        115                 120                 125             


Ser Glu His Phe Leu His Ser Ser Gly Lys Gly Gly Gly Val Ile Gln 
    130                 135                 140                 


Thr Thr Ala Ser Glu Leu Ala Leu Val Val Val Val Ala Ala Arg Glu 
145                 150                 155                 160 


Arg Tyr Leu Arg Ile His Pro Asp Ala Lys Ala Asp Glu Leu Val Ile 
                165                 170                 175     


Tyr Thr Thr Thr Gln Thr His Ser Leu Gly Val Lys Ala Gly Leu Val 
            180                 185                 190         


Phe Gly Met Glu Cys Arg Ala Leu Glu Val Lys Ala Glu Asp Ala Tyr 
        195                 200                 205             


Ala Leu Arg Gly Ala Thr Leu Lys Ser Ala Leu Glu Glu Asp Glu Lys 
    210                 215                 220                 


Arg Gly Lys Arg Pro Phe Ile Leu Val Ala Thr Val Gly Thr Thr Ser 
225                 230                 235                 240 


Ser Gly Ala Ile Asp Arg Leu Asp Glu Ile Gly Gln Val Ser Glu Asp 
                245                 250                 255     


Tyr Pro Ser Leu Trp Ile His Val Asp Ala Ala Trp Ala Gly Val Thr 
            260                 265                 270         


Leu Ala Cys Pro Glu Tyr Arg Gly Thr Ala Gln Leu Glu Asn Ile Asn 
        275                 280                 285             


Ala Tyr Ala Thr Ser Phe Gly Thr Asn Phe His Lys Trp Gly Leu Val 
    290                 295                 300                 


Asn Phe Asp Ala Ala Leu Leu Trp Val Lys Asp Arg Lys Asp Leu Thr 
305                 310                 315                 320 


Asp Ala Leu Asp Val Thr Pro Glu Phe Leu Arg Thr Lys Gln Gly Asp 
                325                 330                 335     


Ala Gly Ala Val Val Asp Phe Arg Asn Trp His Leu Gly Leu Gly Arg 
            340                 345                 350         


Arg Phe Arg Ser Leu Lys Val Trp Phe Val Leu Arg Ser Tyr Gly Val 
        355                 360                 365             


Glu Gly Phe Arg Asn Tyr Ile Arg Gln Gly Ile Lys Leu Asn Glu His 
    370                 375                 380                 


Phe Thr Ser Leu Ile Arg Ala Ser Leu Asp Phe Ser Leu Val Thr Ala 
385                 390                 395                 400 


Pro Ser Phe Ala Leu Thr Val Phe Arg Leu Thr Pro Ala Gly Ala Ser 
                405                 410                 415     


Leu Thr Gly Ser Glu Leu Asn Glu Leu Asn Arg Ala Phe Tyr Ala Arg 
            420                 425                 430         


Leu Ser Ser Arg His Asp Ile Met Leu Thr Gln Thr Val Leu Asn Gly 
        435                 440                 445             


Val Phe Cys Ile Arg Phe Ala Val Gly Ala Ala Arg Thr Gln Gln Glu 
    450                 455                 460                 


His Ile Asp Thr Ala Trp Asp Leu Leu Gln Gln Glu Gly Ala Val Ala 
465                 470                 475                 480 


Val Gln Glu Tyr Met Gln Lys Ile Ser Lys Asp Val Gln 
                485                 490             


<210>  44
<211>  1254
<212>  DNA
<213>  Clostridium sporogenes

<400>  44
atgaagttct ggagaaagta cacacaacaa gaaatggatg aaaagattac tgaatctttg       60

gaaaagactt tgaactacga taacactaag acaatcggta ttccaggtac taagttggat      120

gatacagttt tctatgatga tcattctttc gttaagcatt caccatactt gagaactttt      180

attcaaaacc caaaccatat cggttgtcat acttatgata aggctgatat cttgttcggt      240

ggtacattcg atatcgaaag agaattaatc caattgttag caatcgatgt tttgaacggt      300

aacgatgaag aatttgatgg ttacgttact caaggtggta cagaagctaa catccaagca      360

atgtgggttt acagaaacta cttcaagaaa gaaagaaagg ctaagcatga agaaatcgct      420

atcatcactt cagcagatac acattactct gcatacaaag gttcagattt gttgaacatc      480

gatattatta aggttccagt tgatttttat tcaagaaaaa ttcaagaaaa tacattggat      540

tcaattgtta aagaagctaa agaaattggt aaaaagtact tcatcgttat ctctaacatg      600

ggtactacaa tgtttggttc agttgatgat ccagatttgt acgctaacat cttcgataag      660

tacaatttgg aatacaaaat tcatgttgat ggtgcatttg gtggttttat atatccaatt      720

gataataagg aatgtaaaac tgatttctct aataagaacg tttcttcaat cacattagat      780

ggtcataaga tgttgcaagc tccatacggt actggtatct tcgtttcaag aaagaatttg      840

atccataaca ctttgacaaa ggaagcaact tacatcgaaa atttggatgt tacattgtct      900

ggttcaagat ctggttcaaa tgctgttgca atttggatgg ttttagcttc ttatggtcca      960

tacggttgga tggaaaagat taataagttg agaaatagaa ctaaatggtt gtgtaagcaa     1020

ttgaacgata tgagaattaa atattacaaa gaagattcaa tgaatattgt tacaattgaa     1080

gaacaatatg ttaataagga aatcgctgaa aagtactttt tagttccaga agttcataac     1140

ccaactaaca actggtacaa gatcgttgtt atggaacatg ttgaattgga tatcttgaac     1200

tctttggttt acgatttgag aaagtttaat aaggaacatt tgaaggcaat gtaa           1254


<210>  45
<211>  417
<212>  PRT
<213>  Clostridium sporogenes

<400>  45

Met Lys Phe Trp Arg Lys Tyr Thr Gln Gln Glu Met Asp Glu Lys Ile 
1               5                   10                  15      


Thr Glu Ser Leu Glu Lys Thr Leu Asn Tyr Asp Asn Thr Lys Thr Ile 
            20                  25                  30          


Gly Ile Pro Gly Thr Lys Leu Asp Asp Thr Val Phe Tyr Asp Asp His 
        35                  40                  45              


Ser Phe Val Lys His Ser Pro Tyr Leu Arg Thr Phe Ile Gln Asn Pro 
    50                  55                  60                  


Asn His Ile Gly Cys His Thr Tyr Asp Lys Ala Asp Ile Leu Phe Gly 
65                  70                  75                  80  


Gly Thr Phe Asp Ile Glu Arg Glu Leu Ile Gln Leu Leu Ala Ile Asp 
                85                  90                  95      


Val Leu Asn Gly Asn Asp Glu Glu Phe Asp Gly Tyr Val Thr Gln Gly 
            100                 105                 110         


Gly Thr Glu Ala Asn Ile Gln Ala Met Trp Val Tyr Arg Asn Tyr Phe 
        115                 120                 125             


Lys Lys Glu Arg Lys Ala Lys His Glu Glu Ile Ala Ile Ile Thr Ser 
    130                 135                 140                 


Ala Asp Thr His Tyr Ser Ala Tyr Lys Gly Ser Asp Leu Leu Asn Ile 
145                 150                 155                 160 


Asp Ile Ile Lys Val Pro Val Asp Phe Tyr Ser Arg Lys Ile Gln Glu 
                165                 170                 175     


Asn Thr Leu Asp Ser Ile Val Lys Glu Ala Lys Glu Ile Gly Lys Lys 
            180                 185                 190         


Tyr Phe Ile Val Ile Ser Asn Met Gly Thr Thr Met Phe Gly Ser Val 
        195                 200                 205             


Asp Asp Pro Asp Leu Tyr Ala Asn Ile Phe Asp Lys Tyr Asn Leu Glu 
    210                 215                 220                 


Tyr Lys Ile His Val Asp Gly Ala Phe Gly Gly Phe Ile Tyr Pro Ile 
225                 230                 235                 240 


Asp Asn Lys Glu Cys Lys Thr Asp Phe Ser Asn Lys Asn Val Ser Ser 
                245                 250                 255     


Ile Thr Leu Asp Gly His Lys Met Leu Gln Ala Pro Tyr Gly Thr Gly 
            260                 265                 270         


Ile Phe Val Ser Arg Lys Asn Leu Ile His Asn Thr Leu Thr Lys Glu 
        275                 280                 285             


Ala Thr Tyr Ile Glu Asn Leu Asp Val Thr Leu Ser Gly Ser Arg Ser 
    290                 295                 300                 


Gly Ser Asn Ala Val Ala Ile Trp Met Val Leu Ala Ser Tyr Gly Pro 
305                 310                 315                 320 


Tyr Gly Trp Met Glu Lys Ile Asn Lys Leu Arg Asn Arg Thr Lys Trp 
                325                 330                 335     


Leu Cys Lys Gln Leu Asn Asp Met Arg Ile Lys Tyr Tyr Lys Glu Asp 
            340                 345                 350         


Ser Met Asn Ile Val Thr Ile Glu Glu Gln Tyr Val Asn Lys Glu Ile 
        355                 360                 365             


Ala Glu Lys Tyr Phe Leu Val Pro Glu Val His Asn Pro Thr Asn Asn 
    370                 375                 380                 


Trp Tyr Lys Ile Val Val Met Glu His Val Glu Leu Asp Ile Leu Asn 
385                 390                 395                 400 


Ser Leu Val Tyr Asp Leu Arg Lys Phe Asn Lys Glu His Leu Lys Ala 
                405                 410                 415     


Met 
    


<210>  46
<211>  1443
<212>  DNA
<213>  Homo sapiens

<400>  46
atgaatgcat ctgaattcag aagaagaggt aaagaaatgg ttgattacat ggctaactac       60

atggaaggta ttgaaggtag acaagtttat ccagatgttg aaccaggtta cttgagacca      120

ttaattccag ctgcagctcc acaagaacca gatacatttg aagatattat taacgatgtt      180

gaaaagatta tcatgccagg tgttacacat tggcattcac catatttctt tgcatacttt      240

ccaactgctt cttcatatcc agcaatgttg gctgatatgt tatgtggtgc aattggttgt      300

attggttttt cttgggcagc ttcaccagct tgtacagaat tggaaactgt tatgatggat      360

tggttaggta aaatgttgga attaccaaag gcatttttga acgaaaaggc tggtgaaggt      420

ggtggtgtta ttcaaggttc tgcatcagaa gctacattag ttgctttgtt agcagctaga      480

actaaagtta ttcatagatt gcaagcagct tctccagaat taacacaagc agctatcatg      540

gaaaaattgg ttgcatattc ttcagatcaa gctcattctt cagttgaaag agctggtttg      600

atcggtggtg ttaagttgaa ggcaatccca tctgatggta attttgctat gagagcatca      660

gctttgcaag aagcattaga aagagataaa gcagctggtt tgattccatt tttcatggtt      720

gctactttag gtactacaac ttgttgttct ttcgataatt tgttagaagt tggtccaatt      780

tgtaataagg aagatatttg gttgcatgtt gatgcagctt acgcaggttc agcttttatt      840

tgtccagaat tcagacattt gttgaacggt gttgaattcg ctgattcttt taatttcaat      900

ccacataaat ggttgttagt taacttcgat tgttcagcaa tgtgggttaa gaaaagaaca      960

gatttgactg gtgcttttag attagatcca acatatttga agcattctca tcaagattca     1020

ggtttgatca ctgattacag acattggcaa attccattgg gtagaagatt cagatctttg     1080

aagatgtggt tcgtttttag aatgtacggt gttaagggtt tgcaagctta catcagaaag     1140

catgttcaat tgtctcatga attcgaatca ttagttagac aagatccaag attcgaaatc     1200

tgtgttgaag ttattttggg tttagtttgt ttcagattga agggttctaa taaggttaac     1260

gaagcattgt tgcaaagaat taattcagct aagaaaattc atttggttcc atgtcatttg     1320

cgtgataagt tcgttttgag attcgctatt tgttcaagaa ctgttgaatc agcacatgtt     1380

caaagagctt gggaacatat caaggaattg gcagctgatg ttttgagagc tgaaagagaa     1440

taa                                                                   1443


<210>  47
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Asn Ala Ser Glu Phe Arg Arg Arg Gly Lys Glu Met Val Asp Tyr 
1               5                   10                  15      


Met Ala Asn Tyr Met Glu Gly Ile Glu Gly Arg Gln Val Tyr Pro Asp 
            20                  25                  30          


Val Glu Pro Gly Tyr Leu Arg Pro Leu Ile Pro Ala Ala Ala Pro Gln 
        35                  40                  45              


Glu Pro Asp Thr Phe Glu Asp Ile Ile Asn Asp Val Glu Lys Ile Ile 
    50                  55                  60                  


Met Pro Gly Val Thr His Trp His Ser Pro Tyr Phe Phe Ala Tyr Phe 
65                  70                  75                  80  


Pro Thr Ala Ser Ser Tyr Pro Ala Met Leu Ala Asp Met Leu Cys Gly 
                85                  90                  95      


Ala Ile Gly Cys Ile Gly Phe Ser Trp Ala Ala Ser Pro Ala Cys Thr 
            100                 105                 110         


Glu Leu Glu Thr Val Met Met Asp Trp Leu Gly Lys Met Leu Glu Leu 
        115                 120                 125             


Pro Lys Ala Phe Leu Asn Glu Lys Ala Gly Glu Gly Gly Gly Val Ile 
    130                 135                 140                 


Gln Gly Ser Ala Ser Glu Ala Thr Leu Val Ala Leu Leu Ala Ala Arg 
145                 150                 155                 160 


Thr Lys Val Ile His Arg Leu Gln Ala Ala Ser Pro Glu Leu Thr Gln 
                165                 170                 175     


Ala Ala Ile Met Glu Lys Leu Val Ala Tyr Ser Ser Asp Gln Ala His 
            180                 185                 190         


Ser Ser Val Glu Arg Ala Gly Leu Ile Gly Gly Val Lys Leu Lys Ala 
        195                 200                 205             


Ile Pro Ser Asp Gly Asn Phe Ala Met Arg Ala Ser Ala Leu Gln Glu 
    210                 215                 220                 


Ala Leu Glu Arg Asp Lys Ala Ala Gly Leu Ile Pro Phe Phe Met Val 
225                 230                 235                 240 


Ala Thr Leu Gly Thr Thr Thr Cys Cys Ser Phe Asp Asn Leu Leu Glu 
                245                 250                 255     


Val Gly Pro Ile Cys Asn Lys Glu Asp Ile Trp Leu His Val Asp Ala 
            260                 265                 270         


Ala Tyr Ala Gly Ser Ala Phe Ile Cys Pro Glu Phe Arg His Leu Leu 
        275                 280                 285             


Asn Gly Val Glu Phe Ala Asp Ser Phe Asn Phe Asn Pro His Lys Trp 
    290                 295                 300                 


Leu Leu Val Asn Phe Asp Cys Ser Ala Met Trp Val Lys Lys Arg Thr 
305                 310                 315                 320 


Asp Leu Thr Gly Ala Phe Arg Leu Asp Pro Thr Tyr Leu Lys His Ser 
                325                 330                 335     


His Gln Asp Ser Gly Leu Ile Thr Asp Tyr Arg His Trp Gln Ile Pro 
            340                 345                 350         


Leu Gly Arg Arg Phe Arg Ser Leu Lys Met Trp Phe Val Phe Arg Met 
        355                 360                 365             


Tyr Gly Val Lys Gly Leu Gln Ala Tyr Ile Arg Lys His Val Gln Leu 
    370                 375                 380                 


Ser His Glu Phe Glu Ser Leu Val Arg Gln Asp Pro Arg Phe Glu Ile 
385                 390                 395                 400 


Cys Val Glu Val Ile Leu Gly Leu Val Cys Phe Arg Leu Lys Gly Ser 
                405                 410                 415     


Asn Lys Val Asn Glu Ala Leu Leu Gln Arg Ile Asn Ser Ala Lys Lys 
            420                 425                 430         


Ile His Leu Val Pro Cys His Leu Arg Asp Lys Phe Val Leu Arg Phe 
        435                 440                 445             


Ala Ile Cys Ser Arg Thr Val Glu Ser Ala His Val Gln Arg Ala Trp 
    450                 455                 460                 


Glu His Ile Lys Glu Leu Ala Ala Asp Val Leu Arg Ala Glu Arg Glu 
465                 470                 475                 480 


<210>  48
<211>  1521
<212>  DNA
<213>  Ophiorrhiza pumila

<400>  48
atgggttcta tctcagaaaa ctgtgatgat tctatttcat tagctgcacc ttttagacca       60

ttggaaccag aagaattcag aaagcaagct catgttatgg ttgatttcat cgcagattac      120

tacaagaaca ttgaaaatta tccagttttg tcacaagttg aaccaggtta tttgaaaaat      180

agattgccag aaactgctcc acatttgcca gaatctttcg aaacaatctt gaaggatatt      240

aagaaagata tcgttcctgg tatgactaat tggttgtcac caaatttctt tgcttatttt      300

ccagcaactg tttcttcagc tgcatttgtt ggtgaaatgt tgtgtacagg ttttaattct      360

gttggtttta attggttagc ttcaccagca tctacagaat tggaaatggt tgttattgat      420

tggttagcta acatgttgaa gttgccaaag tcttttatgt ttcatggtac tggtggtggt      480

gttattcaag gtactacatc tgaagctatc ttgtgtacat tgattgctgc aagagatggt      540

gctttggaaa agattggtat ggaaaacgtt ggtaaattag ttgtttacgg ttcagatcaa      600

actcattctt tctttcaaaa gacttgtaag gttgctggta tcttcccatg taacatcaag      660

ttgatcccaa ctacaagaga agataacttc tctatgtcac caatcgcatt gagagaacaa      720

attgaagctg atgttgcaga tggtttagtt ccaattttct tgtgtactac agttggtact      780

acatcaactg ctgcaattga tccagtttct gaagttgcta aggttgcaaa cgatttcaat      840

atttgggttc atgttgatgc tgcttatgct ggttctgcat gtatttgtcc agaattcaga      900

caatacttag atggtatcga attggttgat tctttttcat tgtctccaca taagtggttg      960

ttgtgtttct tggattgttg ttgtttgtgg ttgaagaaac cacatttgat ggttaaggct     1020

ttgtcaacta acccagaata tttgagaaat aagagatctg aattcgatgg tgttgttgat     1080

ttcaaggatt ggcaaatcgg tacaggtaga agattcaaag ctttgagatt atggttggtt     1140

atgagatcat acggtgttga aaatttgaag agacatatct tgtctgatgt tcaaatggct     1200

aagatgttcg aaggtttagt taaatctgat ccaagattcg aaatcatcgt tccaagagct     1260

ttcgcattag tttgtttcag attgaaccct ggtaaaggtt atgatgatga aatcgataag     1320

gaaatcttga ataaggaatt gttagatttg attaattcaa caggtagagc ttacatgact     1380

catacaaaag caggtggtat ctatatgttg agatttgctg ttggtactac attgactgaa     1440

gaacatcatg tttacgctgc atgggaattg attaaagaat gtacagatgc atctttgact     1500

aaaacaaata ttattgaata a                                               1521


<210>  49
<211>  506
<212>  PRT
<213>  Ophiorrhiza pumila

<400>  49

Met Gly Ser Ile Ser Glu Asn Cys Asp Asp Ser Ile Ser Leu Ala Ala 
1               5                   10                  15      


Pro Phe Arg Pro Leu Glu Pro Glu Glu Phe Arg Lys Gln Ala His Val 
            20                  25                  30          


Met Val Asp Phe Ile Ala Asp Tyr Tyr Lys Asn Ile Glu Asn Tyr Pro 
        35                  40                  45              


Val Leu Ser Gln Val Glu Pro Gly Tyr Leu Lys Asn Arg Leu Pro Glu 
    50                  55                  60                  


Thr Ala Pro His Leu Pro Glu Ser Phe Glu Thr Ile Leu Lys Asp Ile 
65                  70                  75                  80  


Lys Lys Asp Ile Val Pro Gly Met Thr Asn Trp Leu Ser Pro Asn Phe 
                85                  90                  95      


Phe Ala Tyr Phe Pro Ala Thr Val Ser Ser Ala Ala Phe Val Gly Glu 
            100                 105                 110         


Met Leu Cys Thr Gly Phe Asn Ser Val Gly Phe Asn Trp Leu Ala Ser 
        115                 120                 125             


Pro Ala Ser Thr Glu Leu Glu Met Val Val Ile Asp Trp Leu Ala Asn 
    130                 135                 140                 


Met Leu Lys Leu Pro Lys Ser Phe Met Phe His Gly Thr Gly Gly Gly 
145                 150                 155                 160 


Val Ile Gln Gly Thr Thr Ser Glu Ala Ile Leu Cys Thr Leu Ile Ala 
                165                 170                 175     


Ala Arg Asp Gly Ala Leu Glu Lys Ile Gly Met Glu Asn Val Gly Lys 
            180                 185                 190         


Leu Val Val Tyr Gly Ser Asp Gln Thr His Ser Phe Phe Gln Lys Thr 
        195                 200                 205             


Cys Lys Val Ala Gly Ile Phe Pro Cys Asn Ile Lys Leu Ile Pro Thr 
    210                 215                 220                 


Thr Arg Glu Asp Asn Phe Ser Met Ser Pro Ile Ala Leu Arg Glu Gln 
225                 230                 235                 240 


Ile Glu Ala Asp Val Ala Asp Gly Leu Val Pro Ile Phe Leu Cys Thr 
                245                 250                 255     


Thr Val Gly Thr Thr Ser Thr Ala Ala Ile Asp Pro Val Ser Glu Val 
            260                 265                 270         


Ala Lys Val Ala Asn Asp Phe Asn Ile Trp Val His Val Asp Ala Ala 
        275                 280                 285             


Tyr Ala Gly Ser Ala Cys Ile Cys Pro Glu Phe Arg Gln Tyr Leu Asp 
    290                 295                 300                 


Gly Ile Glu Leu Val Asp Ser Phe Ser Leu Ser Pro His Lys Trp Leu 
305                 310                 315                 320 


Leu Cys Phe Leu Asp Cys Cys Cys Leu Trp Leu Lys Lys Pro His Leu 
                325                 330                 335     


Met Val Lys Ala Leu Ser Thr Asn Pro Glu Tyr Leu Arg Asn Lys Arg 
            340                 345                 350         


Ser Glu Phe Asp Gly Val Val Asp Phe Lys Asp Trp Gln Ile Gly Thr 
        355                 360                 365             


Gly Arg Arg Phe Lys Ala Leu Arg Leu Trp Leu Val Met Arg Ser Tyr 
    370                 375                 380                 


Gly Val Glu Asn Leu Lys Arg His Ile Leu Ser Asp Val Gln Met Ala 
385                 390                 395                 400 


Lys Met Phe Glu Gly Leu Val Lys Ser Asp Pro Arg Phe Glu Ile Ile 
                405                 410                 415     


Val Pro Arg Ala Phe Ala Leu Val Cys Phe Arg Leu Asn Pro Gly Lys 
            420                 425                 430         


Gly Tyr Asp Asp Glu Ile Asp Lys Glu Ile Leu Asn Lys Glu Leu Leu 
        435                 440                 445             


Asp Leu Ile Asn Ser Thr Gly Arg Ala Tyr Met Thr His Thr Lys Ala 
    450                 455                 460                 


Gly Gly Ile Tyr Met Leu Arg Phe Ala Val Gly Thr Thr Leu Thr Glu 
465                 470                 475                 480 


Glu His His Val Tyr Ala Ala Trp Glu Leu Ile Lys Glu Cys Thr Asp 
                485                 490                 495     


Ala Ser Leu Thr Lys Thr Asn Ile Ile Glu 
            500                 505     


<210>  50
<211>  1545
<212>  DNA
<213>  Oryza sativa

<400>  50
atgggttcat tagatacaaa tccaactgct ttttctgcat ttccagctgg tgaaggtgaa       60

acttttcaac cattgaacgc agatgatgtt agatcatatt tgcataaggc tgttgatttc      120

atctctgatt actacaaatc agttgaatct atgccagttt tgccaaacgt taagccaggt      180

tatttgcaag atgaattaag agcatcacca ccaacttact ctgctccatt cgatgttaca      240

atgaaggaat tgagatcttc agttgttcct ggtatgactc attgggcatc tccaaatttc      300

tttgctttct ttccatcaac aaattctgct gcagctattg ctggtgactt gattgcatca      360

gctatgaata cagttggttt tacttggcaa gcttctccag cagctactga aatggaagtt      420

ttggcattag attggttggc tcaaatgttg aatttgccaa cttcttttat gaacagaact      480

ggtgaaggta gaggtactgg tggtggtgtt attttgggta ctacatctga agctatgttg      540

gttacattag ttgcagctag agatgcagct ttgagaagat ctggttcaga tggtgttgca      600

ggtttgcata gattagctgt ttatgcagct gatcaaacac attcaacttt ctttaaggca      660

tgtagattgg ctggttttga tccagcaaat attagatcta ttccaacagg tgctgaaact      720

gattatggtt tagatccagc aagattgtta gaagctatgc aagcagatgc tgatgcaggt      780

ttagttccaa catacgtttg tgcaactgtt ggtactacat cttcaaatgc tgttgatcca      840

gttggtgctg ttgcagatgt tgcagctaga tttgcagctt gggttcatgt tgatgcagct      900

tacgcaggtt cagcttgtat ttgtccagaa ttcagacatc atttggatgg tgttgaaaga      960

gttgattcta tctcaatgtc tccacataag tggttgatga catgtttaga ttgtacttgt     1020

ttgtacgtta gagatacaca tagattgact ggttctttag aaactaaccc agaatacttg     1080

aaaaatcatg cttcagattc tggtgaagtt acagatttga aagatatgca agttggtgtt     1140

ggtagaagat tcagaggttt gaagttgtgg atggttatga gaacttatgg tgttgctaag     1200

ttgcaagaac atatcagatc agatgttgct atggcaaaag tttttgaaga tttggttaga     1260

ggtgacgata gattcgaagt tgttgttcca agaaacttcg ctttggtttg tttcagaatt     1320

agagctggtg caggtgcagc tgcagctaca gaagaagatg cagatgaagc taacagagaa     1380

ttgatggaaa gattgaataa gactggtaaa gcatacgttg ctcatacagt tgttggtggt     1440

agatttgttt tgagatttgc agttggttct tcattacaag aagaacatca tgttagatct     1500

gcttgggaat tgattaagaa aactacaact gaaatgatga actaa                     1545


<210>  51
<211>  514
<212>  PRT
<213>  Oryza sativa

<400>  51

Met Gly Ser Leu Asp Thr Asn Pro Thr Ala Phe Ser Ala Phe Pro Ala 
1               5                   10                  15      


Gly Glu Gly Glu Thr Phe Gln Pro Leu Asn Ala Asp Asp Val Arg Ser 
            20                  25                  30          


Tyr Leu His Lys Ala Val Asp Phe Ile Ser Asp Tyr Tyr Lys Ser Val 
        35                  40                  45              


Glu Ser Met Pro Val Leu Pro Asn Val Lys Pro Gly Tyr Leu Gln Asp 
    50                  55                  60                  


Glu Leu Arg Ala Ser Pro Pro Thr Tyr Ser Ala Pro Phe Asp Val Thr 
65                  70                  75                  80  


Met Lys Glu Leu Arg Ser Ser Val Val Pro Gly Met Thr His Trp Ala 
                85                  90                  95      


Ser Pro Asn Phe Phe Ala Phe Phe Pro Ser Thr Asn Ser Ala Ala Ala 
            100                 105                 110         


Ile Ala Gly Asp Leu Ile Ala Ser Ala Met Asn Thr Val Gly Phe Thr 
        115                 120                 125             


Trp Gln Ala Ser Pro Ala Ala Thr Glu Met Glu Val Leu Ala Leu Asp 
    130                 135                 140                 


Trp Leu Ala Gln Met Leu Asn Leu Pro Thr Ser Phe Met Asn Arg Thr 
145                 150                 155                 160 


Gly Glu Gly Arg Gly Thr Gly Gly Gly Val Ile Leu Gly Thr Thr Ser 
                165                 170                 175     


Glu Ala Met Leu Val Thr Leu Val Ala Ala Arg Asp Ala Ala Leu Arg 
            180                 185                 190         


Arg Ser Gly Ser Asp Gly Val Ala Gly Leu His Arg Leu Ala Val Tyr 
        195                 200                 205             


Ala Ala Asp Gln Thr His Ser Thr Phe Phe Lys Ala Cys Arg Leu Ala 
    210                 215                 220                 


Gly Phe Asp Pro Ala Asn Ile Arg Ser Ile Pro Thr Gly Ala Glu Thr 
225                 230                 235                 240 


Asp Tyr Gly Leu Asp Pro Ala Arg Leu Leu Glu Ala Met Gln Ala Asp 
                245                 250                 255     


Ala Asp Ala Gly Leu Val Pro Thr Tyr Val Cys Ala Thr Val Gly Thr 
            260                 265                 270         


Thr Ser Ser Asn Ala Val Asp Pro Val Gly Ala Val Ala Asp Val Ala 
        275                 280                 285             


Ala Arg Phe Ala Ala Trp Val His Val Asp Ala Ala Tyr Ala Gly Ser 
    290                 295                 300                 


Ala Cys Ile Cys Pro Glu Phe Arg His His Leu Asp Gly Val Glu Arg 
305                 310                 315                 320 


Val Asp Ser Ile Ser Met Ser Pro His Lys Trp Leu Met Thr Cys Leu 
                325                 330                 335     


Asp Cys Thr Cys Leu Tyr Val Arg Asp Thr His Arg Leu Thr Gly Ser 
            340                 345                 350         


Leu Glu Thr Asn Pro Glu Tyr Leu Lys Asn His Ala Ser Asp Ser Gly 
        355                 360                 365             


Glu Val Thr Asp Leu Lys Asp Met Gln Val Gly Val Gly Arg Arg Phe 
    370                 375                 380                 


Arg Gly Leu Lys Leu Trp Met Val Met Arg Thr Tyr Gly Val Ala Lys 
385                 390                 395                 400 


Leu Gln Glu His Ile Arg Ser Asp Val Ala Met Ala Lys Val Phe Glu 
                405                 410                 415     


Asp Leu Val Arg Gly Asp Asp Arg Phe Glu Val Val Val Pro Arg Asn 
            420                 425                 430         


Phe Ala Leu Val Cys Phe Arg Ile Arg Ala Gly Ala Gly Ala Ala Ala 
        435                 440                 445             


Ala Thr Glu Glu Asp Ala Asp Glu Ala Asn Arg Glu Leu Met Glu Arg 
    450                 455                 460                 


Leu Asn Lys Thr Gly Lys Ala Tyr Val Ala His Thr Val Val Gly Gly 
465                 470                 475                 480 


Arg Phe Val Leu Arg Phe Ala Val Gly Ser Ser Leu Gln Glu Glu His 
                485                 490                 495     


His Val Arg Ser Ala Trp Glu Leu Ile Lys Lys Thr Thr Thr Glu Met 
            500                 505                 510         


Met Asn 
        


<210>  52
<211>  1494
<212>  DNA
<213>  Oryza sativa

<400>  52
atggaaggtg ttggtggtgg tggtggtggt gaagaatggt tgagaccaat ggatgcagaa       60

caattaagag aatgtggtca tagaatggtt gatttcgttg cagattacta caagtcaatc      120

gaagcttttc cagttttgtc tcaagttcaa ccaggttatt tgaaagaagt tttgccagat      180

tcagctccaa gacaaccaga tactttagat tctttgttcg atgatatcca acaaaagatt      240

atcccaggtg ttacacattg gcaatcacca aactacttcg catactaccc atctaattct      300

tctactgctg gtttcttggg tgaaatgttg tctgctgctt ttaatatcgt tggtttttca      360

tggatcactt ctccagctgc aacagaattg gaagttattg ttttagattg gttcgcaaag      420

atgttgcaat tgccatcaca attcttatct actgctttgg gtggtggtgt tattcaaggt      480

acagcttcag aagcagtttt ggttgcattg ttagctgcaa gagatagagc tttgaagaaa      540

catggtaaac attctttaga aaaattggtt gtttacgcat cagatcaaac tcattctgct      600

ttacaaaaag catgtcaaat cgctggtatt ttctctgaaa acgttagagt tgttattgct      660

gattgtaata agaactacgc tgttgcacca gaagcagttt cagaagcttt gtctatcgat      720

ttgtcttcag gtttgatccc atttttcatt tgtgcaacag ttggtactac atcttcatct      780

gctgttgatc cattaccaga attgggtcaa atcgctaagt caaacgatat gtggttccat      840

atcgatgctg cttatgctgg ttctgcatgt atttgtccag aatacagaca tcatttgaat      900

ggtgttgaag aagcagattc ttttaatatg aatgctcata agtggttctt gactaacttc      960

gattgttcat tgttgtgggt taaggataga tcatttttga tccaatcatt atctacaaat     1020

ccagaattct tgaaaaataa ggcttcacaa gcaaactctg ttgttgattt caaggattgg     1080

caaatcccat tgggtagaag attcagatca ttgaagttgt ggatggtttt gagattgtac     1140

ggtgttgata atttgcaatc ttacatcaga aagcatatcc atttggctga acatttcgaa     1200

caattgttgt tgtcagattc aagattcgaa gttgttactc caagaacatt ttcattggtt     1260

tgtttcagat tagttccacc aacttctgat catgaaaacg gtagaaagtt gaactacgat     1320

atgatggatg gtgttaattc atctggtaaa attttcttgt cacatacagt tttgtctggt     1380

aaattcgttt tgagatttgc tgttggtgca ccattaactg aagaaagaca tgttgatgct     1440

gcatggaagt tgttgagaga tgaagctaca aaggttttag gtaaaatggt ttaa           1494


<210>  53
<211>  497
<212>  PRT
<213>  Oryza sativa

<400>  53

Met Glu Gly Val Gly Gly Gly Gly Gly Gly Glu Glu Trp Leu Arg Pro 
1               5                   10                  15      


Met Asp Ala Glu Gln Leu Arg Glu Cys Gly His Arg Met Val Asp Phe 
            20                  25                  30          


Val Ala Asp Tyr Tyr Lys Ser Ile Glu Ala Phe Pro Val Leu Ser Gln 
        35                  40                  45              


Val Gln Pro Gly Tyr Leu Lys Glu Val Leu Pro Asp Ser Ala Pro Arg 
    50                  55                  60                  


Gln Pro Asp Thr Leu Asp Ser Leu Phe Asp Asp Ile Gln Gln Lys Ile 
65                  70                  75                  80  


Ile Pro Gly Val Thr His Trp Gln Ser Pro Asn Tyr Phe Ala Tyr Tyr 
                85                  90                  95      


Pro Ser Asn Ser Ser Thr Ala Gly Phe Leu Gly Glu Met Leu Ser Ala 
            100                 105                 110         


Ala Phe Asn Ile Val Gly Phe Ser Trp Ile Thr Ser Pro Ala Ala Thr 
        115                 120                 125             


Glu Leu Glu Val Ile Val Leu Asp Trp Phe Ala Lys Met Leu Gln Leu 
    130                 135                 140                 


Pro Ser Gln Phe Leu Ser Thr Ala Leu Gly Gly Gly Val Ile Gln Gly 
145                 150                 155                 160 


Thr Ala Ser Glu Ala Val Leu Val Ala Leu Leu Ala Ala Arg Asp Arg 
                165                 170                 175     


Ala Leu Lys Lys His Gly Lys His Ser Leu Glu Lys Leu Val Val Tyr 
            180                 185                 190         


Ala Ser Asp Gln Thr His Ser Ala Leu Gln Lys Ala Cys Gln Ile Ala 
        195                 200                 205             


Gly Ile Phe Ser Glu Asn Val Arg Val Val Ile Ala Asp Cys Asn Lys 
    210                 215                 220                 


Asn Tyr Ala Val Ala Pro Glu Ala Val Ser Glu Ala Leu Ser Ile Asp 
225                 230                 235                 240 


Leu Ser Ser Gly Leu Ile Pro Phe Phe Ile Cys Ala Thr Val Gly Thr 
                245                 250                 255     


Thr Ser Ser Ser Ala Val Asp Pro Leu Pro Glu Leu Gly Gln Ile Ala 
            260                 265                 270         


Lys Ser Asn Asp Met Trp Phe His Ile Asp Ala Ala Tyr Ala Gly Ser 
        275                 280                 285             


Ala Cys Ile Cys Pro Glu Tyr Arg His His Leu Asn Gly Val Glu Glu 
    290                 295                 300                 


Ala Asp Ser Phe Asn Met Asn Ala His Lys Trp Phe Leu Thr Asn Phe 
305                 310                 315                 320 


Asp Cys Ser Leu Leu Trp Val Lys Asp Arg Ser Phe Leu Ile Gln Ser 
                325                 330                 335     


Leu Ser Thr Asn Pro Glu Phe Leu Lys Asn Lys Ala Ser Gln Ala Asn 
            340                 345                 350         


Ser Val Val Asp Phe Lys Asp Trp Gln Ile Pro Leu Gly Arg Arg Phe 
        355                 360                 365             


Arg Ser Leu Lys Leu Trp Met Val Leu Arg Leu Tyr Gly Val Asp Asn 
    370                 375                 380                 


Leu Gln Ser Tyr Ile Arg Lys His Ile His Leu Ala Glu His Phe Glu 
385                 390                 395                 400 


Gln Leu Leu Leu Ser Asp Ser Arg Phe Glu Val Val Thr Pro Arg Thr 
                405                 410                 415     


Phe Ser Leu Val Cys Phe Arg Leu Val Pro Pro Thr Ser Asp His Glu 
            420                 425                 430         


Asn Gly Arg Lys Leu Asn Tyr Asp Met Met Asp Gly Val Asn Ser Ser 
        435                 440                 445             


Gly Lys Ile Phe Leu Ser His Thr Val Leu Ser Gly Lys Phe Val Leu 
    450                 455                 460                 


Arg Phe Ala Val Gly Ala Pro Leu Thr Glu Glu Arg His Val Asp Ala 
465                 470                 475                 480 


Ala Trp Lys Leu Leu Arg Asp Glu Ala Thr Lys Val Leu Gly Lys Met 
                485                 490                 495     


Val 
    


<210>  54
<211>  1944
<212>  DNA
<213>  Xenorhabdus doucetiae

<400>  54
atgacaaagc cattccatcc aaatttgaac gttgatgcat tgtttttagg tccaaagtct       60

gaaaacgctg ttttctttag agaaatgatg gattatgcag tttctgaaca catgcattgg      120

agatcaggtt ttcatccaga agattctaca ttggttactt cagttgatag atacgaacat      180

aactacagag aaacattgta cagaactgaa ggtattttga atcaattatc tgctaagttg      240

aaaaattctt caatcccatt tttctctcca agatacttag gtcatatttc ttcagatact      300

ttgatggttt ctaatttggc ttatgttatg gctatgatgt acaacccaaa caactgttct      360

tatgaagctt caccaactac aactgaattg gaattagaat ctggtttgga tttgtgtaga      420

atgttcggtt acaatccaca acaatcttgg ggtcatatta catcaggtgg tactgttgca      480

aattacgaag gtttgtgggt tgctagaaat ttgaagacat tgtctttcgc aatctcacaa      540

catccaaagg ctaaggattt gatcgaacat aagactccaa agcaattgaa aaatatgcca      600

acatctgaat tgttagattt gatcactgaa ttacaaaaga gaggtttgtt cgaagaaatc      660

agagatatga catgtagagg tactggtgtt aaggctcaaa ttttaggtaa attgttagtt      720

ccacaatcta agcattattc atggatgaaa gctgcagata tcttcggtat cggtcaagaa      780

aacatcatcc cattgccagt taatgatcat taccaaacag atgttgctca aatgagaaag      840

atcactttcg gtttgattga acaaggtgaa ccaattttag caatgattgc tgttgttggt      900

acaactgaag ttggtgcaat cgatagaatc gatgaagtta ttgctttaag aaaagaatgt      960

gaagaaagat acggtgaatc tttctacatc catgttgatg ctgcttatgc tggttacgct     1020

tgttcaatgt tgttgaacga acagggtgaa ttcgttgaat acgatgaatt ggcaaactac     1080

catagatctg ctggtattat gccagaaaat atttcatggc caaaaccaga agtttaccaa     1140

tcttttaaag ctttgaaaga tgttgattca attacagttg atccacataa ggttggtttt     1200

attcaatatg ctgcaggtgc aatttgtatg aaggataaga gaattttgga attaatttct     1260

tcacatgctg catacgtttt tgaaggtcat gctgataaga catctactaa aaatagaggt     1320

attttgggtt cttcaattat ggaaggttct aaatcaggtg caacagctgc agctttgtgg     1380

gcagctcata gattgttacc attgaacatc aacggttacg gtaaagttat tgcagctggt     1440

atcgttactg cacaatcttt gttgaataag ttggctaatt tgccaccaat cgaaatcggt     1500

aaacatagat tcgaagttca tatttttcca tcaccagatt tccacatgat caacttcact     1560

tttaaagaag ttggtaacga atctttgtca aaccataacg ctttgaataa gagattgtat     1620

gaattatgtt cttactcagc aggtagagct tacacaaatg atttcttgac atcttcaact     1680

attttagatt acaaggaata cggtgacact ccttggcatc atgctcaaaa atgtggtttt     1740

tcaagatcag aatgggaaaa agttagaaac atctatgttt tgagagcagc tgttatgaca     1800

tactgtttga gagatgaaga acatttcgaa gaattctggg aacaattgca agctatcttc     1860

gttaagaaat tgactcaaat cgttgatgaa gaagataaga aagcaagatt gagattagaa     1920

ccagatgttc cttttattgg ttaa                                            1944


<210>  55
<211>  647
<212>  PRT
<213>  Xenorhabdus doucetiae

<400>  55

Met Thr Lys Pro Phe His Pro Asn Leu Asn Val Asp Ala Leu Phe Leu 
1               5                   10                  15      


Gly Pro Lys Ser Glu Asn Ala Val Phe Phe Arg Glu Met Met Asp Tyr 
            20                  25                  30          


Ala Val Ser Glu His Met His Trp Arg Ser Gly Phe His Pro Glu Asp 
        35                  40                  45              


Ser Thr Leu Val Thr Ser Val Asp Arg Tyr Glu His Asn Tyr Arg Glu 
    50                  55                  60                  


Thr Leu Tyr Arg Thr Glu Gly Ile Leu Asn Gln Leu Ser Ala Lys Leu 
65                  70                  75                  80  


Lys Asn Ser Ser Ile Pro Phe Phe Ser Pro Arg Tyr Leu Gly His Ile 
                85                  90                  95      


Ser Ser Asp Thr Leu Met Val Ser Asn Leu Ala Tyr Val Met Ala Met 
            100                 105                 110         


Met Tyr Asn Pro Asn Asn Cys Ser Tyr Glu Ala Ser Pro Thr Thr Thr 
        115                 120                 125             


Glu Leu Glu Leu Glu Ser Gly Leu Asp Leu Cys Arg Met Phe Gly Tyr 
    130                 135                 140                 


Asn Pro Gln Gln Ser Trp Gly His Ile Thr Ser Gly Gly Thr Val Ala 
145                 150                 155                 160 


Asn Tyr Glu Gly Leu Trp Val Ala Arg Asn Leu Lys Thr Leu Ser Phe 
                165                 170                 175     


Ala Ile Ser Gln His Pro Lys Ala Lys Asp Leu Ile Glu His Lys Thr 
            180                 185                 190         


Pro Lys Gln Leu Lys Asn Met Pro Thr Ser Glu Leu Leu Asp Leu Ile 
        195                 200                 205             


Thr Glu Leu Gln Lys Arg Gly Leu Phe Glu Glu Ile Arg Asp Met Thr 
    210                 215                 220                 


Cys Arg Gly Thr Gly Val Lys Ala Gln Ile Leu Gly Lys Leu Leu Val 
225                 230                 235                 240 


Pro Gln Ser Lys His Tyr Ser Trp Met Lys Ala Ala Asp Ile Phe Gly 
                245                 250                 255     


Ile Gly Gln Glu Asn Ile Ile Pro Leu Pro Val Asn Asp His Tyr Gln 
            260                 265                 270         


Thr Asp Val Ala Gln Met Arg Lys Ile Thr Phe Gly Leu Ile Glu Gln 
        275                 280                 285             


Gly Glu Pro Ile Leu Ala Met Ile Ala Val Val Gly Thr Thr Glu Val 
    290                 295                 300                 


Gly Ala Ile Asp Arg Ile Asp Glu Val Ile Ala Leu Arg Lys Glu Cys 
305                 310                 315                 320 


Glu Glu Arg Tyr Gly Glu Ser Phe Tyr Ile His Val Asp Ala Ala Tyr 
                325                 330                 335     


Ala Gly Tyr Ala Cys Ser Met Leu Leu Asn Glu Gln Gly Glu Phe Val 
            340                 345                 350         


Glu Tyr Asp Glu Leu Ala Asn Tyr His Arg Ser Ala Gly Ile Met Pro 
        355                 360                 365             


Glu Asn Ile Ser Trp Pro Lys Pro Glu Val Tyr Gln Ser Phe Lys Ala 
    370                 375                 380                 


Leu Lys Asp Val Asp Ser Ile Thr Val Asp Pro His Lys Val Gly Phe 
385                 390                 395                 400 


Ile Gln Tyr Ala Ala Gly Ala Ile Cys Met Lys Asp Lys Arg Ile Leu 
                405                 410                 415     


Glu Leu Ile Ser Ser His Ala Ala Tyr Val Phe Glu Gly His Ala Asp 
            420                 425                 430         


Lys Thr Ser Thr Lys Asn Arg Gly Ile Leu Gly Ser Ser Ile Met Glu 
        435                 440                 445             


Gly Ser Lys Ser Gly Ala Thr Ala Ala Ala Leu Trp Ala Ala His Arg 
    450                 455                 460                 


Leu Leu Pro Leu Asn Ile Asn Gly Tyr Gly Lys Val Ile Ala Ala Gly 
465                 470                 475                 480 


Ile Val Thr Ala Gln Ser Leu Leu Asn Lys Leu Ala Asn Leu Pro Pro 
                485                 490                 495     


Ile Glu Ile Gly Lys His Arg Phe Glu Val His Ile Phe Pro Ser Pro 
            500                 505                 510         


Asp Phe His Met Ile Asn Phe Thr Phe Lys Glu Val Gly Asn Glu Ser 
        515                 520                 525             


Leu Ser Asn His Asn Ala Leu Asn Lys Arg Leu Tyr Glu Leu Cys Ser 
    530                 535                 540                 


Tyr Ser Ala Gly Arg Ala Tyr Thr Asn Asp Phe Leu Thr Ser Ser Thr 
545                 550                 555                 560 


Ile Leu Asp Tyr Lys Glu Tyr Gly Asp Thr Pro Trp His His Ala Gln 
                565                 570                 575     


Lys Cys Gly Phe Ser Arg Ser Glu Trp Glu Lys Val Arg Asn Ile Tyr 
            580                 585                 590         


Val Leu Arg Ala Ala Val Met Thr Tyr Cys Leu Arg Asp Glu Glu His 
        595                 600                 605             


Phe Glu Glu Phe Trp Glu Gln Leu Gln Ala Ile Phe Val Lys Lys Leu 
    610                 615                 620                 


Thr Gln Ile Val Asp Glu Glu Asp Lys Lys Ala Arg Leu Arg Leu Glu 
625                 630                 635                 640 


Pro Asp Val Pro Phe Ile Gly 
                645         


<210>  56
<211>  1509
<212>  DNA
<213>  Camptotheca acuminata

<400>  56
atgggttctt tggattcaaa ctacgatact gaatctccag cttcagttgg tcaattcaat       60

ccattagatc cagaagaatt cagaaagcaa gctcattgta tcgttgattt catcgcagat      120

tactacaaga acattgaatc ttatccagtt ttgtcacaag ttgatccagg ttacagacat      180

tcaagattgg gtaaaaatgc tccatacaga tctgaaccat tcgaatcaat cttgaaggat      240

gttcaaaagg atatcatccc tggtatgact cattggatgt ctccaaattt ctttgctcat      300

tttccagcaa ctgtttcttc agctgcattt gttggtgaaa tgttgtgtac atgtttcaac      360

tctgttggtt ttaattggtt agcatcacca gctgcaacag aattggaaat ggttgttatt      420

gattggttag ctaacatgtt gaagttgcca aagtctttta tgttttcagg tactggtggt      480

ggtgttttgc aaggtactac atctgaagct atcttgtgta cattgattgc tgcatcacca      540

atgcatttcg aaatcgttgg tgttaagact tctacatcat tcgttgttta tggttctgat      600

caaactcatt caacatacgc taaagcatgt aaattagcag gtattttgcc atgtaacatc      660

agatctattc caactacagc tgattcaaac ttctctgttt caccattgtt gttgagaaga      720

gctattgaag cagataaagc tgcaggtatg gttccattgt atatttgtgc tacagttggt      780

actacatcta ctacagcaat tgatccatta tcttcattgg ctgatgttgc aaatgattat      840

ggtgtttggt ttcatgttga tgctgcatac gctggttctg catgtatttg tccagaattc      900

agacattatt tggatggtat cgaaagagca gattctttgt cattgtctcc acataagtgg      960

ttgttgtctt acttagattg ttgttgtttg tgggttaagt caccatcttt attggttaag     1020

gctttatcaa ctgatccaga atatttgaaa aatcaaccat cagaatctaa gtcagttgtt     1080

gattacaagg attggcaagt tggtacaggt agaagattca aagctttgag attgtggttc     1140

gttatgagat cttatggtgt tgcaaatttg caatcacata tcagaactga tgttcaaatg     1200

gctaagatgt tcgaaggttt cgttaagtct gatccaagat tcgaaatttt ggttccaaga     1260

gttttctctt tggtttgttt cagattgaac ccaatctctg gttcagatcc aactggtaca     1320

gaagctttga acagaaagtt attggattgg gttaattcta caggtagagt ttatatgact     1380

catacaaaag ttggtggtat ctatatgttg agatttgctg ttggtgcaac tttaacagaa     1440

aagagacatg tttcttcagc ttggaagttg attaaagaag gtgcagatgt tttgttgaag     1500

gaagattaa                                                             1509


<210>  57
<211>  502
<212>  PRT
<213>  Camptotheca acuminata

<400>  57

Met Gly Ser Leu Asp Ser Asn Tyr Asp Thr Glu Ser Pro Ala Ser Val 
1               5                   10                  15      


Gly Gln Phe Asn Pro Leu Asp Pro Glu Glu Phe Arg Lys Gln Ala His 
            20                  25                  30          


Cys Ile Val Asp Phe Ile Ala Asp Tyr Tyr Lys Asn Ile Glu Ser Tyr 
        35                  40                  45              


Pro Val Leu Ser Gln Val Asp Pro Gly Tyr Arg His Ser Arg Leu Gly 
    50                  55                  60                  


Lys Asn Ala Pro Tyr Arg Ser Glu Pro Phe Glu Ser Ile Leu Lys Asp 
65                  70                  75                  80  


Val Gln Lys Asp Ile Ile Pro Gly Met Thr His Trp Met Ser Pro Asn 
                85                  90                  95      


Phe Phe Ala His Phe Pro Ala Thr Val Ser Ser Ala Ala Phe Val Gly 
            100                 105                 110         


Glu Met Leu Cys Thr Cys Phe Asn Ser Val Gly Phe Asn Trp Leu Ala 
        115                 120                 125             


Ser Pro Ala Ala Thr Glu Leu Glu Met Val Val Ile Asp Trp Leu Ala 
    130                 135                 140                 


Asn Met Leu Lys Leu Pro Lys Ser Phe Met Phe Ser Gly Thr Gly Gly 
145                 150                 155                 160 


Gly Val Leu Gln Gly Thr Thr Ser Glu Ala Ile Leu Cys Thr Leu Ile 
                165                 170                 175     


Ala Ala Ser Pro Met His Phe Glu Ile Val Gly Val Lys Thr Ser Thr 
            180                 185                 190         


Ser Phe Val Val Tyr Gly Ser Asp Gln Thr His Ser Thr Tyr Ala Lys 
        195                 200                 205             


Ala Cys Lys Leu Ala Gly Ile Leu Pro Cys Asn Ile Arg Ser Ile Pro 
    210                 215                 220                 


Thr Thr Ala Asp Ser Asn Phe Ser Val Ser Pro Leu Leu Leu Arg Arg 
225                 230                 235                 240 


Ala Ile Glu Ala Asp Lys Ala Ala Gly Met Val Pro Leu Tyr Ile Cys 
                245                 250                 255     


Ala Thr Val Gly Thr Thr Ser Thr Thr Ala Ile Asp Pro Leu Ser Ser 
            260                 265                 270         


Leu Ala Asp Val Ala Asn Asp Tyr Gly Val Trp Phe His Val Asp Ala 
        275                 280                 285             


Ala Tyr Ala Gly Ser Ala Cys Ile Cys Pro Glu Phe Arg His Tyr Leu 
    290                 295                 300                 


Asp Gly Ile Glu Arg Ala Asp Ser Leu Ser Leu Ser Pro His Lys Trp 
305                 310                 315                 320 


Leu Leu Ser Tyr Leu Asp Cys Cys Cys Leu Trp Val Lys Ser Pro Ser 
                325                 330                 335     


Leu Leu Val Lys Ala Leu Ser Thr Asp Pro Glu Tyr Leu Lys Asn Gln 
            340                 345                 350         


Pro Ser Glu Ser Lys Ser Val Val Asp Tyr Lys Asp Trp Gln Val Gly 
        355                 360                 365             


Thr Gly Arg Arg Phe Lys Ala Leu Arg Leu Trp Phe Val Met Arg Ser 
    370                 375                 380                 


Tyr Gly Val Ala Asn Leu Gln Ser His Ile Arg Thr Asp Val Gln Met 
385                 390                 395                 400 


Ala Lys Met Phe Glu Gly Phe Val Lys Ser Asp Pro Arg Phe Glu Ile 
                405                 410                 415     


Leu Val Pro Arg Val Phe Ser Leu Val Cys Phe Arg Leu Asn Pro Ile 
            420                 425                 430         


Ser Gly Ser Asp Pro Thr Gly Thr Glu Ala Leu Asn Arg Lys Leu Leu 
        435                 440                 445             


Asp Trp Val Asn Ser Thr Gly Arg Val Tyr Met Thr His Thr Lys Val 
    450                 455                 460                 


Gly Gly Ile Tyr Met Leu Arg Phe Ala Val Gly Ala Thr Leu Thr Glu 
465                 470                 475                 480 


Lys Arg His Val Ser Ser Ala Trp Lys Leu Ile Lys Glu Gly Ala Asp 
                485                 490                 495     


Val Leu Leu Lys Glu Asp 
            500         


<210>  58
<211>  792
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  58
atggaaggtg gttttactgg tggtgacgaa taccaaaagc atttcttgcc aagagattac       60

ttaaacacat actactcatt ccaatctggt ccatcaccag aagctgaaat gttgaagttt      120

aatttggaat gtttgcataa gactttcggt ccaggtggtt tgcaaggtga cactttaatt      180

gatattggtt ctggtccaac aatctatcaa gttttggctg catgtgaatc ttttaaagat      240

atcactttgt cagattttac agatagaaat agagaagaat tggctaaatg gttgaagaaa      300

gaaccaggtg catacgattg gactccagct ttgaagttcg catgtgaatt agaaggcaac      360

tctggtagat ggcaagaaaa agctgaaaag ttgagagcaa cagttaagag agttttgaag      420

tgtgatgcta atttgtcaaa tccattaact ccagttgttt tgccaccagc agattgtgtt      480

ttgacattgt tagctatgga atgtgcatgt tgttctttgg atgcttatag agctgcattg      540

agaaatttgg catcattgtt aaaaccaggt ggtcatttgg ttactacagt tactttgcaa      600

ttatcttcat acatggttgg tgaaagagaa ttttcttgtg ttgctttgga aaaagaagaa      660

gttgaacaag ctgttttaga tgcaggtttc gatatcgaac aattgttgta ctctccacaa      720

tcttactcag cttctacagc accaaataga ggtgtttgtt tcttggttgc tagaaagaaa      780

ccaggttcat aa                                                          792


<210>  59
<211>  263
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  59

Met Glu Gly Gly Phe Thr Gly Gly Asp Glu Tyr Gln Lys His Phe Leu 
1               5                   10                  15      


Pro Arg Asp Tyr Leu Asn Thr Tyr Tyr Ser Phe Gln Ser Gly Pro Ser 
            20                  25                  30          


Pro Glu Ala Glu Met Leu Lys Phe Asn Leu Glu Cys Leu His Lys Thr 
        35                  40                  45              


Phe Gly Pro Gly Gly Leu Gln Gly Asp Thr Leu Ile Asp Ile Gly Ser 
    50                  55                  60                  


Gly Pro Thr Ile Tyr Gln Val Leu Ala Ala Cys Glu Ser Phe Lys Asp 
65                  70                  75                  80  


Ile Thr Leu Ser Asp Phe Thr Asp Arg Asn Arg Glu Glu Leu Ala Lys 
                85                  90                  95      


Trp Leu Lys Lys Glu Pro Gly Ala Tyr Asp Trp Thr Pro Ala Leu Lys 
            100                 105                 110         


Phe Ala Cys Glu Leu Glu Gly Asn Ser Gly Arg Trp Gln Glu Lys Ala 
        115                 120                 125             


Glu Lys Leu Arg Ala Thr Val Lys Arg Val Leu Lys Cys Asp Ala Asn 
    130                 135                 140                 


Leu Ser Asn Pro Leu Thr Pro Val Val Leu Pro Pro Ala Asp Cys Val 
145                 150                 155                 160 


Leu Thr Leu Leu Ala Met Glu Cys Ala Cys Cys Ser Leu Asp Ala Tyr 
                165                 170                 175     


Arg Ala Ala Leu Arg Asn Leu Ala Ser Leu Leu Lys Pro Gly Gly His 
            180                 185                 190         


Leu Val Thr Thr Val Thr Leu Gln Leu Ser Ser Tyr Met Val Gly Glu 
        195                 200                 205             


Arg Glu Phe Ser Cys Val Ala Leu Glu Lys Glu Glu Val Glu Gln Ala 
    210                 215                 220                 


Val Leu Asp Ala Gly Phe Asp Ile Glu Gln Leu Leu Tyr Ser Pro Gln 
225                 230                 235                 240 


Ser Tyr Ser Ala Ser Thr Ala Pro Asn Arg Gly Val Cys Phe Leu Val 
                245                 250                 255     


Ala Arg Lys Lys Pro Gly Ser 
            260             


<210>  60
<211>  1131
<212>  DNA
<213>  Hordeum vulgare

<400>  60
atggataaga tctctgcacc atttttctct ggtacttcac cagctgcagc ttcagttgct       60

ggtgttgatg aagatgatag attgtgtttc caagctcaag aattgatgtt cgcatacaac      120

atctctatgg ttttgagagc agctattcaa ttaggtttgt tagatgcttt gtcagcagct      180

ggtggtaaag cattgactcc aaacgaatta gttgaaaacg ttgaaacatc ttcaaataag      240

gctgaagcag ctgcagctgt tgatagaatt ttgagatatt tgtcttgttt caacgttgtt      300

acttgttctt cagaagcagc tggtccagat ggtacattag ttagaagata cactacaggt      360

ccattgtgta gatggttaac taaagataga ggtgacggta cattatctcc atttgctgtt      420

tttgttgttg atccagatca tttgtttcct tggcatcata ttgcagaagc tgttactgct      480

ggtggtccat cagcattcga aagaacacaa aagtggccat actacgaata catgggtaaa      540

aatcaaagat tgggtacttt gttcgataac gcaatggctc aacattctgt tattttggtt      600

acaaagatgt tagaaagatt caaaggtttt gatggtgttc aaagattagt tgatgttggt      660

ggtggtactg gttctacatt gggtatgatc acttcaaagt acaagcacat gacaggtatt      720

aattacgatt tgccacatgt tattgctcaa ggtttgccat taccaggtgt tgaacatgtt      780

gcaggtgaca tgtacgaatc tattccaact ggtgacgctg ttttgttaca atggattaca      840

ttgatgttga acgatgatga attcgttaag atcttgtcaa attgtcataa tgctttgcca      900

aaagatggta aagttattgt tgttgatggt attttaccag aaaacccaga ttcttcattg      960

actgcaagag atgcttttac attagatatc atcatgttcg ttttgtttaa aggtgcaaag     1020

caaagaactg aaaaggaatt cgcaagatta gctaagcaag caggttttac tggtggtatt     1080

aagaaaactt atattttctt taatttttac gctttggaat tcactaaata a              1131


<210>  61
<211>  376
<212>  PRT
<213>  Hordeum vulgare

<400>  61

Met Asp Lys Ile Ser Ala Pro Phe Phe Ser Gly Thr Ser Pro Ala Ala 
1               5                   10                  15      


Ala Ser Val Ala Gly Val Asp Glu Asp Asp Arg Leu Cys Phe Gln Ala 
            20                  25                  30          


Gln Glu Leu Met Phe Ala Tyr Asn Ile Ser Met Val Leu Arg Ala Ala 
        35                  40                  45              


Ile Gln Leu Gly Leu Leu Asp Ala Leu Ser Ala Ala Gly Gly Lys Ala 
    50                  55                  60                  


Leu Thr Pro Asn Glu Leu Val Glu Asn Val Glu Thr Ser Ser Asn Lys 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Val Asp Arg Ile Leu Arg Tyr Leu Ser Cys 
                85                  90                  95      


Phe Asn Val Val Thr Cys Ser Ser Glu Ala Ala Gly Pro Asp Gly Thr 
            100                 105                 110         


Leu Val Arg Arg Tyr Thr Thr Gly Pro Leu Cys Arg Trp Leu Thr Lys 
        115                 120                 125             


Asp Arg Gly Asp Gly Thr Leu Ser Pro Phe Ala Val Phe Val Val Asp 
    130                 135                 140                 


Pro Asp His Leu Phe Pro Trp His His Ile Ala Glu Ala Val Thr Ala 
145                 150                 155                 160 


Gly Gly Pro Ser Ala Phe Glu Arg Thr Gln Lys Trp Pro Tyr Tyr Glu 
                165                 170                 175     


Tyr Met Gly Lys Asn Gln Arg Leu Gly Thr Leu Phe Asp Asn Ala Met 
            180                 185                 190         


Ala Gln His Ser Val Ile Leu Val Thr Lys Met Leu Glu Arg Phe Lys 
        195                 200                 205             


Gly Phe Asp Gly Val Gln Arg Leu Val Asp Val Gly Gly Gly Thr Gly 
    210                 215                 220                 


Ser Thr Leu Gly Met Ile Thr Ser Lys Tyr Lys His Met Thr Gly Ile 
225                 230                 235                 240 


Asn Tyr Asp Leu Pro His Val Ile Ala Gln Gly Leu Pro Leu Pro Gly 
                245                 250                 255     


Val Glu His Val Ala Gly Asp Met Tyr Glu Ser Ile Pro Thr Gly Asp 
            260                 265                 270         


Ala Val Leu Leu Gln Trp Ile Thr Leu Met Leu Asn Asp Asp Glu Phe 
        275                 280                 285             


Val Lys Ile Leu Ser Asn Cys His Asn Ala Leu Pro Lys Asp Gly Lys 
    290                 295                 300                 


Val Ile Val Val Asp Gly Ile Leu Pro Glu Asn Pro Asp Ser Ser Leu 
305                 310                 315                 320 


Thr Ala Arg Asp Ala Phe Thr Leu Asp Ile Ile Met Phe Val Leu Phe 
                325                 330                 335     


Lys Gly Ala Lys Gln Arg Thr Glu Lys Glu Phe Ala Arg Leu Ala Lys 
            340                 345                 350         


Gln Ala Gly Phe Thr Gly Gly Ile Lys Lys Thr Tyr Ile Phe Phe Asn 
        355                 360                 365             


Phe Tyr Ala Leu Glu Phe Thr Lys 
    370                 375     


<210>  62
<211>  549
<212>  DNA
<213>  Streptomyces griseofuscus

<400>  62
atgaacacct tcagaacagc cactgccaga gacatacctg atgtagcagc aactcttacg       60

gaagccttcg caactgatcc acccacgcag tgggtgttcc ccgacggtac tgccgccgtc      120

agcaggttct ttacacatgt tgcagatagg gttcacacgg ccggtggtat tgttgagcta      180

ctaccagaca gagccgccat gattgcattg ccaccacacg tgaggctgcc aggagaagct      240

gccgacggaa ggcaggcgga aattcagaga aggctggcag acaggcaccc gctgacacct      300

cactactacc tgctgtttta cggagttaga acggcacacc agggttcggg attgggcgga      360

agaatgctgg ccagattaac tagcagagct gatagggaca gggtgggtac atatactgag      420

gcatccacct ggcgtggcgc tagactgatg ctgagacatg gattccatgc tacaaggcca      480

ctaagattgc cagatggacc cagcatgttt ccactttgga gagatccaat ccatgatcat      540

tctgattag                                                              549


<210>  63
<211>  182
<212>  PRT
<213>  Streptomyces griseofuscus

<400>  63

Met Asn Thr Phe Arg Thr Ala Thr Ala Arg Asp Ile Pro Asp Val Ala 
1               5                   10                  15      


Ala Thr Leu Thr Glu Ala Phe Ala Thr Asp Pro Pro Thr Gln Trp Val 
            20                  25                  30          


Phe Pro Asp Gly Thr Ala Ala Val Ser Arg Phe Phe Thr His Val Ala 
        35                  40                  45              


Asp Arg Val His Thr Ala Gly Gly Ile Val Glu Leu Leu Pro Asp Arg 
    50                  55                  60                  


Ala Ala Met Ile Ala Leu Pro Pro His Val Arg Leu Pro Gly Glu Ala 
65                  70                  75                  80  


Ala Asp Gly Arg Gln Ala Glu Ile Gln Arg Arg Leu Ala Asp Arg His 
                85                  90                  95      


Pro Leu Thr Pro His Tyr Tyr Leu Leu Phe Tyr Gly Val Arg Thr Ala 
            100                 105                 110         


His Gln Gly Ser Gly Leu Gly Gly Arg Met Leu Ala Arg Leu Thr Ser 
        115                 120                 125             


Arg Ala Asp Arg Asp Arg Val Gly Thr Tyr Thr Glu Ala Ser Thr Trp 
    130                 135                 140                 


Arg Gly Ala Arg Leu Met Leu Arg His Gly Phe His Ala Thr Arg Pro 
145                 150                 155                 160 


Leu Arg Leu Pro Asp Gly Pro Ser Met Phe Pro Leu Trp Arg Asp Pro 
                165                 170                 175     


Ile His Asp His Ser Asp 
            180         


<210>  64
<211>  1170
<212>  DNA
<213>  Thermotoga maritima

<400>  64
atgaaaggat atttcggacc atacggtggc cagtacgtac cagaaatatt aatgggtgcc       60

ttagaggagt tagaggcagc atacgaggag attatgaagg atgagagctt ctggaaggag      120

ttcaacgatc tactgaggga ttacgcaggc agaccaacgc cattgtactt tgccaggaga      180

ttgtctgaga agtacggcgc ccgtgtttac ttgaagcgtg aggatctgct gcacactgga      240

gcacacaaga taaataacgc tatcggacag gttttattgg ccaaattaat ggggaagaca      300

cgtatcatag ccgagacggg agctgggcag catggagtcg ctactgctac cgctgctgcc      360

ctgttcggaa tggaatgtgt gatctacatg ggtgaagagg acacaatcag acagaagttg      420

aacgtggagc gtatgaaatt attaggggct aaagttgtcc ctgttaagtc tggcagtagg      480

accttgaagg atgcgataga cgaggctttg agagactgga ttactaattt acagacaaca      540

tattatgtta tcggatctgt tgttggtccc cacccttacc caattatcgt aaggaatttc      600

cagaaggtta tcggtgagga gaccaagaag caaataccag aaaaggaagg tcgtttgcca      660

gactatatag ttgcctgcgt aggcggcggt agcaatgccg caggtatatt ttacccattc      720

atagactctg gagtaaagct gataggtgtt gaggcaggtg gcgagggatt ggagacaggt      780

aaacacgcag cctcgttatt aaagggtaaa attggctatt tacatggatc gaagaccttt      840

gttctacaag atgactgggg tcaagtccaa gtgagccatt cggtgtcagc tggtcttgac      900

tattcaggag taggacctga gcatgcttat tggagagaga cagggaaggt tctgtacgac      960

gcagtgactg acgaagaggc tttggacgca tttatagagt tatcaagact agagggcatt     1020

atacccgctt tagagtcatc gcatgctcta gcatatttga agaagataaa tataaaaggt     1080

aaggttgtgg tggtcaacct atcagggaga ggggataaag acctggagtc agtcttaaac     1140

catccatacg tgagagaaag aattagatga                                      1170


<210>  65
<211>  389
<212>  PRT
<213>  Thermotoga maritima

<400>  65

Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile 
1               5                   10                  15      


Leu Met Gly Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met 
            20                  25                  30          


Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr 
        35                  40                  45              


Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys 
    50                  55                  60                  


Tyr Gly Ala Arg Val Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly 
65                  70                  75                  80  


Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Leu 
                85                  90                  95      


Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly 
            100                 105                 110         


Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile 
        115                 120                 125             


Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Leu Asn Val Glu Arg 
    130                 135                 140                 


Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg 
145                 150                 155                 160 


Thr Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Ile Thr Asn 
                165                 170                 175     


Leu Gln Thr Thr Tyr Tyr Val Ile Gly Ser Val Val Gly Pro His Pro 
            180                 185                 190         


Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr 
        195                 200                 205             


Lys Lys Gln Ile Pro Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val 
    210                 215                 220                 


Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe 
225                 230                 235                 240 


Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly 
                245                 250                 255     


Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly 
            260                 265                 270         


Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln 
        275                 280                 285             


Val Gln Val Ser His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg 
                325                 330                 335     


Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr 
            340                 345                 350         


Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser 
        355                 360                 365             


Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val 
    370                 375                 380                 


Arg Glu Arg Ile Arg 
385                 


<210>  66
<211>  1167
<212>  DNA
<213>  Pyrococcus furiosus

<400>  66
atgtggttcg gtgagtttgg tggacaatat gtgccagaga ctttagtggg tcctcttaag       60

gaattggaaa aggcatataa aaggttcaag gacgatgagg agttcaacag gcaactaaac      120

tattatttga agacatgggc cggtagacca acgcccttgt attatgctaa gaggttaact      180

gaaaagattg gcggcgcgaa agtgtatctg aaaagagaag acctagttca tggtggagca      240

cacaagacaa ataatgccat tggacaagca ctattggcaa agctaatggg taaaactaga      300

ttgatagctg agacaggagc gggtcaacat ggggtcgcga cagcgatggc tggtgcacta      360

ctggggatga aggtagatat ttacatgggt gctgaggacg ttgagcgtca gaaactaaat      420

gtcttcagga tgaagctatt aggtgccaat gttatacctg taaattctgg ctcaagaaca      480

ctaaaggacg ccttcgacga ggctcttaga gactgggttg ccactttcga gtatactcat      540

tacttgatcg gttcagtggt tggaccacat ccatacccaa ccatcgttag ggactttcag      600

agcgtgattg gtagagaggc taaggcacag atcttagaag cagagggaca gctacctgac      660

gtcatagttg cctgcgtcgg cggtggctct aacgcaatgg gtatattcta tccattcgtt      720

aatgacaaga aggttaaatt agtaggagtc gaagctggcg gaaaggggtt agagtcgggt      780

aaacactcag caagcttaaa tgcaggacag gtaggggtgt cccacggcat gttgtcgtat      840

ttcttgcaag acgaggaagg tcagataaag ccaagtcatt caattgctcc aggccttgac      900

caccccggtg ttggtccaga gcacgcttac ttaaagaaga ttcaaagggc cgagtacgtc      960

gctgtaacag acgaagaggc attgaaagct ttccatgagc tatccagaac tgaggggatt     1020

atacccgccc ttgagtctgc ccatgctgtg gcgtacgcca tgaagttagc taaagagatg     1080

tcccgtgacg aaatcatcat tgtaaatcta tcagggagag gagacaagga tttggacatt     1140

gtattgaagg caagcggaaa tgtttga                                         1167


<210>  67
<211>  388
<212>  PRT
<213>  Pyrococcus furiosus

<400>  67

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Phe Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp His Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  68
<211>  1167
<212>  DNA
<213>  Pyrococcus furiosus

<400>  68
atgtggtttg gggaattcgg tggtcaatac gtgccagaaa ccttagttgg gcctttaaag       60

gagcttgaga aagcttacaa aagatttaag gacgacgagg agtttaatag gcaattaaac      120

tattacttga agacttgggc aggtagacca acaccacttt attacgcgaa gagacttaca      180

gagaagatcg gtggcgctaa ggtttatttg aagcgtgagg atttggttca tggtggagca      240

cataagacaa acaatgccat cgggcaagcc ttgttggcca aattgatggg taagactagg      300

ttgatagctg gcacaggtgc cggccagcat ggcgttgcaa cagcaatggc tggtgctctt      360

ttagggatga aggtggatat ctatatgggc gccgaggacg ttgaaagaca aaagcttaac      420

gtattcagaa tgaagttatt aggtgcgaat gttattccag tgaattcagg ttccaggacg      480

ctgaaggacg caatagacga agccttgaga gactgggttg ctacttttga gtacacacat      540

tatttgattg gttccgtggt tggaccccac ccgtacccta caatagttag agattttcaa      600

tctgttatcg gtagagaggc gaaggctcaa attccagagg ccgagggaca gctacccgat      660

gttatagtcg cctgcgttgg aggaggatca aatgcgatgg gaatcttcta cccttttgta      720

aatgataaga aagttaagtt agtcggagtt gaggccggtg gtaaagggct agaaagcggc      780

aaacactcgg catctcttaa tgccggtcaa gtaggagtaa gtcacgggat gttatcttac      840

ttcttgcagg atgaggaagg tcaaattaag ccatctcatt ctatagcccc aggattagac      900

tatcccggtg ttgggcctga gcacgcttat ctgaagaaga tacagcgtgc tgagtacgtt      960

gcagtaactg atgaagaggc tttgaaggct tttcacgagt tatcaagaac tgagggaata     1020

attcctgcct tggaatcggc acatgcggtt gcctacgcca tgaagcttgc taaggaaatg     1080

tcaagagacg aaatcattat agtgaattta tcgggaaggg gcgataagga cttggacatt     1140

gttttaaaag caagtggcaa tgtataa                                         1167


<210>  69
<211>  388
<212>  PRT
<213>  Pyrococcus furiosus

<400>  69

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  70
<211>  1173
<212>  DNA
<213>  Pyrococcus furiosus

<400>  70
atgtggtttg gtgagtttgg tggtcagtat gtgcctgaga cgctagttgg gccactgaag       60

gagttagaga aagcgtacaa gagattcaaa gatgacgagg agtttaaccg tcagttgaat      120

tattatctta agacgtgggc tggtaggccg acccctctat actacgctaa gcgtttaacc      180

gaaaagatag gtggcgccaa gatctatctg aagagagagg acctagtcca cggcggggct      240

cacaaaacta acaacgcaat tggtcaggca ccattagcaa agttaatggg caaaacacgt      300

ctaattgccg aaactggtgc tggtcaacat ggagttgcta cggcaatggc gggcgcactg      360

ttaggtatga aagtggatat ctatatggga gcagaagacg tggagagaca gaagatgaac      420

gtgttccgta tgaaactatt gggagctaat gttatcccgg ttaactctgg ctcaagaact      480

gcaaaggacg ccataaacga agctttgagg gattgggaag ccacattcga gtacacacac      540

taccttatag gctcagtcgt aggcccgcat ccctacccca ccatagttcg tgacttccag      600

agtgttattg gccgtgaggc caaggcacag atcttggaag ctgaaggtca attgcctgac      660

gtaatagttg catgtgtggg tggcggttct aacgctatgg gtatattcta ccccttcgtg      720

aacgataaga aagtaaagct agttggagtg gaagcaggtg gcaaagggtt ggagtcgggc      780

aagcactcag cctcattaaa cgcaggtcag gtaggcgttc tgcacggtat gttatcctat      840

ttcttacagg acgaggaagg ccaaatcaaa ccatcgcact caatcgcacc tggtttagat      900

tacccaggag tcggtcccga gcacgcatat ttaaagaaaa tccagagagc agagtacgtc      960

acggtgacgg atgaggaagc ccttaaagcg tttcacgagc tgtcgaggac cgagggcata     1020

atacctgctc ttgaaagtgc ccacgcagtt gcctatgcta tgaagttggc caaggagatg     1080

agtagagacg agattatcat agtaaatctg tcaggcagag gtgacaagga tcttgacata     1140

gtccttaagg cgagcggtaa tgttttggag taa                                  1173


<210>  71
<211>  390
<212>  PRT
<213>  Pyrococcus furiosus

<400>  71

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Ile Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Pro Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Ala Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Glu Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Leu His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Thr Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val Leu Glu 
385                 390 


<210>  72
<211>  1173
<212>  DNA
<213>  Pyrococcus furiosus

<400>  72
atgtggttcg gagagttcgg cgggcagtac gtcccagaaa cgctagtcgg cccactgaag       60

gagctggaga aagcatacaa aagattcaag gatgacgagg agttcaacag gcaattaaac      120

tattacctaa agacctgggc tggtaggccc acccctttat actatgcaaa acgtttaacg      180

gagaaaatcg gtggcgcaaa agtgtacttg aagagagaag acttagtcca cggtggtgct      240

cataaaacta acaacgctat agggcaggca cttttagcta agttgatggg taaaacgagg      300

ttgattgcgg gtaccggtgc cggtcaacat ggcgttgcta cggcaatggc gggagcccta      360

ttgggcatga aggttgacat ttatatgggc gctgaggacg tggaacgtca gaaactgaac      420

gtctatcgta tgaaattgct tggtgccaac gttataccag tcaattccgg ctcgcgtacg      480

gttaaagacg ctttcgatga ggcactatgt gatagagttg ccactttcga atacacccac      540

tatcttattg gtactgtctg gggtccacat ccgtatccaa ctattgtaag ggacttccag      600

actgttatcg gaagagaggc aaaggcccaa atattagagg ctgagggaag gttacccgac      660

gccattgttg catgcgtagg cggtggtagt aacgcaatgg gtattttcta tcccttcgtt      720

aacgataaga aggttaagtt agtgggtgtc gaggccggtg gtaaggggct tgagtccggt      780

aaacattccg catctttgaa tgctgggcaa gtaggtgtca gtcatggaat gttatcatac      840

tttctacagg acgaggaagg acagataaaa ccttctcatt ctatagcgcc aggtcttgac      900

caccctggcg ttggaccaga gcatgcttat ttgaagaaga tccagagagc tgaatatgta      960

gctgttacgg atgaggaagc tctaaaggcg ttccacgagt taagtaggac tgagggaatt     1020

ataccggcat tagagtctgc ccacgctgta gcttacgcaa tgaagctggc caaagagatg     1080

agccgtgacg agatcatcat cgtaaacttg tctggcagag gcgataagga cctagacatc     1140

gtattaaagg cctcggggaa cgtcctagag tag                                  1173


<210>  73
<211>  390
<212>  PRT
<213>  Pyrococcus furiosus

<400>  73

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Tyr Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Val Lys Asp Ala Phe Asp Glu Ala Leu Cys Asp Arg Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Thr Val Trp Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Thr Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Arg Leu Pro Asp Ala Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp His Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val Leu Glu 
385                 390 


<210>  74
<211>  6347
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  74
gtatccggct gttccttcat agccctttca atgaacgttg cagccctttg aagattggcc       60

attttgtcag gactcgagcc tgacagttgg accaacgcaa ctttaatttt ttgtgaaaga      120

atcttcgaag cactcatact ggcgatcttc acgccctcct gctattacaa aagctgtgtt      180

tttacaagaa tcaaattaag ttagcaagat attatacaac attattgata atttcaatat      240

cgtgttcgta cctgatgacg tatctgtgca ttgataaggc ccgcatggtt tcagaaagca      300

gagcggaacg attccaaatt agtggccttg tgctttgcat gtcaattgtg ttaccttcag      360

ctcgtggatt tgttttatca atacacagtc tacagtcaag aatttttttt atcaaatttt      420

gcgttcgagc gtataaaata gccgctgtag ctacttaagt tcctgttcag cgatagtttt      480

tttccatcac acgtactatg gcaattaagt cctcagcgag ctcgcatgga atgcgtgcga      540

tgagcgacct catgctatac ctgagaaagc aacctgacct acaggaaaga gttactcaag      600

aataagaatt ttcgttttaa aacctaagag tcactttaaa atttgtatac acttattttt      660

tttataactt atttaataat aaaaatcata aatcataaga aattcgctta tttagaagtg      720

tcaacaacgt atctaccaac ggaatgcgtg cgattcaggc gtagtctgga acgtcgtatg      780

ggtatggacc agagacggat tgagaaactt gttcggttct tgggacgaat ctacattgga      840

atggaactgg gtgcctgaag aaaccagtgg tgaaatcagc tgggatgtca attggcttac      900

cgttttggtc aactggtctt tcaatgttga aagcagacaa caaagtagca ccggcaatcc      960

aaacagtaga ttgagctagg tgaatacctg ggcagtttct tctaccgtaa ccgaaagcag     1020

cctttcttgg gtctctaaca gtgttgtctg gtttaccatc aggacccaag tatctttctg     1080

gacggaaaac ggatggatct ggatagactt ctgggtcatt caaaactgcc caggtgttag     1140

caaaaaccaa tgtgttcttt ggaatcaaat aacctctgta aacatcatcc ttcatcaatt     1200

tatgagggat ggctaatgga gcaatttggt tccatctgaa taattccttg atacaagcgg     1260

tcaaatatgg gagtgagtcg tcttcctcat cgtagtcagg gatttgaccg ttgttggtca     1320

aagcatccaa ttcagcttga acctttcttt gcacttctgg gtatttaacc atggccaata     1380

tgaaagcgga catagcagag acggtagtgt cgccaccacc aacgttaact tcagcagcag     1440

tgttcttgat aacatgttct tggtgttcta aatcaccgtt caagtccata gcttgtaatc     1500

tagcagaagc gtaagatggt ctggttagac cttgtggagc caactttctc atagtttcgt     1560

atggcatgtc aaccatgtgg tcagcggctt ctctccagac cttggcctta cgcttgaaga     1620

cggcacctgg gaaccaagct ggcaagtact tcaaagatgg gaaggagtca acccagaact     1680

tacctggaac actagcaatg gccaaacctt cgttggctaa gtgggtagct tctaaccatg     1740

ggtcatcttc ggctagatcg ataccgtaac caatgtccaa agacatagca gcgatttgat     1800

gtctgatgtg ttgagcccac cggtccggag tcttggtcaa ttgttgaacc aattggtgag     1860

cagccttgac ttgagcgtgt ctgaattgct tgataccctt ttcagagaat tccttagcaa     1920

acattcttct ttcttctctc caacggtcac cgtaagtgat aaaacccaga tcaaattccc     1980

aacccatcaa ttcattgacc atagtggatt ccaatctacc ggagtagatg gaaccacgtt     2040

tttccaagag atccgtgata gtttccaagg tgtttaaaat gaccatttcg gtaccaccag     2100

catctacgta caagatatca gtgttgtagt cacgacccca ttgcaagaaa gtcaaccatg     2160

gagattcttc tggcatgtcg aacatgttac caataaatgg gattggaatt cctggtggac     2220

caggtggcaa tctggatcta cgaactcttc tggagacgat gtagtaaata caaccagcaa     2280

tgacgaaaga gaacaagaca gcaatcattg ttttatattt gttgtaaaaa gtagataatt     2340

acttccttga tgatctgtaa aaaagagaaa aagaaagcat ctaagaactt gaaaaactac     2400

gaattagaaa agaccaaata tgtatttctt gcattgacca atttatgcaa gtttatatat     2460

atgtaaatgt aagtttcacg aggttctact aaactaaacc acccccttgg ttagaagaaa     2520

agagtgtgtg agaacaggct gttgttgtca cacgattcgg acaattctgt ttgaaagaga     2580

gagagtaaca gtacgatcga acgaactttg ctctggagat cacagtgggc atcatagcat     2640

gtggtactaa accctttccc gccattccag aaccttcgat tgcttgttac aaaacctgtg     2700

agccgtcgct aggaccttgt tgtgtgacga aattggaagc tgcaatcaat aggaagacag     2760

gaagtcgagc gtgtctgggt tttttcagtt ttgttctttt tgcaaacaac agtttattcc     2820

tggcatccac taaatataat ggagcccgct ttttaagctg gcatccagaa aaaaaaagaa     2880

tcccagcacc aaaatattgt tttcttcacc aaccatcagt tcataggtcc attctcttag     2940

cgcaactaca gagaacaggg gcacaaacag gcaaaaaacg ggcacaacct caatggagtg     3000

atgcaacctg cctggagtaa atgatgacac aaggcaattg acccacgcat gtatctatct     3060

cattttctta caccttctat taccttctgc tctctctgat ttggaaaaag ctgaaaaaaa     3120

aggttgaaac cagttccctg aaattattcc cctacttgac taataagtat ataaagacgg     3180

taggtattga ttgtaattct gtaaatctat ttcttaaact tcttaaattc tacttttata     3240

gttagtcttt tttttagttt taaaacacca agaacttagt ttcgaataaa cacacataaa     3300

caaacaaaat ggcttctagt tcttccgatg tcttcgtttt gggtctaggt gttgttttgg     3360

ctgccttgta tatcttcaga gaccaattat tcgctgcttc taagccaaag gtggctccag     3420

tttccactac gaagcctgcc aacggttccg ctaacccaag agacttcatc gccaagatga     3480

aacaaggtaa gaagagaatc gtaatcttct acggttctca aactggtacc gctgaagaat     3540

atgctattcg tttggctaag gaagctaagc aaaagttcgg tctagcctcc ttggtttgtg     3600

atccagaaga atacgatttt gaaaagttgg accaattgcc agaagattct attgctttct     3660

tcgtcgttgc tacctatggt gaaggtgaac ctacagacaa cgctgtccaa ttgttgcaaa     3720

acttgcaaga tgaaagcttc gaattctcct ctggtgagag aaagttgtca ggtttgaagt     3780

acgttgtttt tggtctgggt aacaagacct acgaacatta caacctcatt gggagaactg     3840

ttgacgctca attggccaag atgggtgcta tcagaatcgg tgaaagaggt gaaggtgatg     3900

atgacaagtc catggaagaa gactacttgg aatggaagga tggtatgtgg gaagcgtttg     3960

ccactgctat gggtgttgaa gaaggtcaag gtggtgactc cgctgatttc gtcgtttccg     4020

aattggaatc tcacccacca gaaaaggttt accaaggtga attttctgct agagctttaa     4080

ccaaaaccaa gggtattcac gacgctaaga atccttttgc tgctccaatt gcggttgcta     4140

gagaattgtt ccaatctgtt gtcgatagaa actgtgtcca cgtcgaattc aacattgaag     4200

gctctggtat cacctatcaa cacggtgacc acgttggttt gtggccattg aatccagatg     4260

ttgaagtcga acggttgttg tgtgttttag gtttagctga aaagagagat gctgtcatct     4320

ccattgaatc cttagacccg gctttggcta aggttccatt cccagtccca actacttacg     4380

gtgctgtgtt gagacactac attgacatct ctgctgtcgc cggtagacaa atcttgggta     4440

ctttgtccaa attcgctcca accccagaag ctgaagcttt cttgagaaac ttgaacacta     4500

acaaggaaga ataccacaac gtcgtcgcta acggttgttt gaaattgggt gaaattttgc     4560

aaatcgctac cggtaacgac attactgtcc caccaactac tgccaacacc accaaatggc     4620

caattccatt cgacatcatt gtttctgcca tcccaagatt gcaaccaaga tactactcta     4680

tctcttcttc cccaaaaatt catccaaaca ccatccacgc taccgttgtt gtgctcaaat     4740

acgaaaacgt tccaaccgaa ccaatcccaa gaaagtgggt ttacggtgtc ggtagtaact     4800

tcttgttgaa tttaaagtac gctgttaaca aggaaccagt tccatacatc actcaaaatg     4860

gcgaacaaag agtcggtgtc ccggaatact tgattgctgg tccacgtggt tcttacaaga     4920

ctgaatcttt ctacaaggct ccaatccatg ttagacgttc tactttccgt ttgccaacca     4980

acccaaagtc tccagtcatc atgattggtc caggtactgg tgtcgcccca ttcagaggct     5040

tcgttcaaga aagagttgcc ttggccagaa gatccatcga aaagaacggt cctgactctt     5100

tggctgactg gggtcgtatt tccttgttct acggttgtag aagatccgac gaagacttct     5160

tgtacaagga cgaatggcca caatacgaag ctgagttgaa gggtaagttc aagttgcact     5220

gtgctttctc cagacaaaac tacaagccag acggttctaa gatttacgtc caagatttga     5280

tctgggaaga cagagaacac attgccgatg ccatcttaaa cggtaagggt tacgtctaca     5340

tctgcggtga agctaagtcc atgtctaaac aagttgaaga agttctagcc aagatcttgg     5400

gcgaagccaa aggtggttcc ggtccagttg aaggtgttgc tgaagtcaag ttactgaagg     5460

aacggtccag attgatgttg gatgtctggt ctgaacaaaa gttaatttct gaagaagatt     5520

tggaatgaat cgcgtgcatt catccgctct aaccgaaaag gaaggagtta gacaacctga     5580

agtctaggtc cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt     5640

tcaaattttt cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac     5700

cttgcttgag aaggttttgg gacgctcgaa gatcgcgtcc caattcgccc tatagtgagt     5760

cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     5820

ttacccctgc aggactagtg ctgaggcatt aatagtttac tcaattcttg aagccaattt     5880

gtacaattcc ccattagagt caaataaaag gatgcctcac ggaggtatgt tacccgcgct     5940

atttcacatg gctcattgaa ttagaggtgg aatttggtgt accctcccct cctcatctga     6000

tgaagtagtg atccgacaat tcttaaaagt tgtagacatt acttttacca ccaactaagt     6060

tgtatttata ttgctaccct tatcctttta tatctaacta gcgctcataa ggttggggca     6120

atactaaaac tgtgttctta ttcaactcat taaatacgtg gcagtacgta ccctattaga     6180

aacaatagga aacagcagag tcggaagaag ccaaatgcca gatttgaagt ccaaaacctt     6240

gtcaagccaa tctttgggag cggctattcc tccagaaatt gtgtaccaaa tacttacata     6300

ccagtttagg gatttgttaa gaaatgacca tccaggtacg gcagaaa                   6347


<210>  75
<211>  4792
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  75
caatctggcg gcttgagttc tcaacatgtt ttatttttta cttatattgc tggtagggta       60

aaaaaatata actcctagga ataggttgtc tatatgtttt tgtcttgctt ctataattgt      120

aacaaacaag gaaagggaaa atactgggtg taaaagccat tgagtcaagt taggtcatcc      180

cttttataca aaatttttca attttttttc caagattctt gtacgattaa ttattttttt      240

tttgcgtcct acagcgtgat gaaaatttcg cctgctgcaa gatgagcggg aacgggcgaa      300

atgtgcacgc gcacaactta cgaaacgcgg atgagtcact gacagccacc gcagaggttc      360

tgactcctac tgagctctat tggaggtggc agaaccggta ccggaggagg ccgctataac      420

cggtttgaat ttattgtcac agtgtcacat cagcattaag tcctcagcga gctcgcatgg      480

aatgcgtgcg atgagcgacc tcatgctata cctgagaaag caacctgacc tacaggaaag      540

agttactcaa gaataagaat tttcgtttta aaacctaaga gtcactttaa aatttgtata      600

cacttatttt ttttataact tatttaataa taaaaatcat aaatcataag aaattcgctt      660

atttagaagt gtcaacaacg tatctaccaa cggaatgcgt gcgattcagg tggagtccaa      720

acccaacaaa ggatttggaa ttggcttacc ggcagtggag gattccttta gcaacgtgga      780

agtgatttca ccgttgtcgt tgttacctct agcatcgtgg aaagcagcaa cacccttctt      840

aacaaagttg attctttctt cttcagaacc ccattgcatg aagtcagtcc acataacaat      900

gtgagcggcg ataccagcgg taaccttggc gtagttgatg gaatgcttgg aagtacgggc      960

gtaagattgc aagtaagctt gtctcatggt tgtaccaact tgttcgtctt ggaatctgct     1020

aatcaagtaa cagtcaccca agaagtaacc caaatccaat gaagctggac cgtacttaca     1080

caattcccag tctaagatgt agatcttttg caacttagat gggttacctt cttcaagttg     1140

caacaagatg ttcccagacc acaagtcagc catgaccaaa gtttcttcgg agtgcataac     1200

atcgtcaact agatccttga caacagttgg caacaatgga tcatcgacgc cgtatttagc     1260

ggcgtttggg ataatagttt ggtacaattg gtcagaggtg gttctaccga caatgttacc     1320

agagaagaac ttgaattctg ggtcgtctct tctttctcta cctatgttgt gcaatctggc     1380

gacgaaacca ccaatctcgg taccaaccaa tctagcaata tcggtagcca aaggtggctt     1440

agcagtaacg tagtctaata aggtcttcat tttaccgaca tcttgcataa tcaaagcatt     1500

gttttccaag tcatagttga gaccttctgg aacagagaca ataccatcaa caccacccaa     1560

aacttctctg ttagccatca tcaacttgat agcttggtat tcgtagacag aacgttcaac     1620

accgattttg aaatcttcat cagtagacat gtgtggttga gcgtgcttca aaatgataga     1680

agtgtgacct tggtatggag cgttcaattt aatacgccag gtgacgttaa cgaaaccacc     1740

ggataatctc ttgacaccag aagtgtcaac atctaaagac aaatgcttgg tcaaataggt     1800

gattaaaccg tcttcagtct tcaagtcaaa ggccattgtt ttatatttgt tgtaaaaagt     1860

agataattac ttccttgatg atctgtaaaa aagagaaaaa gaaagcatct aagaacttga     1920

aaaactacga attagaaaag accaaatatg tatttcttgc attgaccaat ttatgcaagt     1980

ttatatatat gtaaatgtaa gtttcacgag gttctactaa actaaaccac ccccttggtt     2040

agaagaaaag agtgtgtgag aacaggctgt tgttgtcaca cgattcggac aattctgttt     2100

gaaagagaga gagtaacagt acgatcgaac gaactttgct ctggagatca cagtgggcat     2160

catagcatgt ggtactaaac cctttcccgc cattccagaa ccttcgattg cttgttacaa     2220

aacctgtgag ccgtcgctag gaccttgttg tgtgacgaaa ttggaagctg caatcaatag     2280

gaagacagga agtcgagcgt gtctgggttt tttcagtttt gttctttttg caaacaacag     2340

tttattcctg gcatccacta aatataatgg agcccgcttt ttaagctggc atccagaaaa     2400

aaaaagaatc ccagcaccaa aatattgttt tcttcaccaa ccatcagttc ataggtccat     2460

tctcttagcg caactacaga gaacaggggc acaaacaggc aaaaaacggg cacaacctca     2520

atggagtgat gcaacctgcc tggagtaaat gatgacacaa ggcaattgac ccacgcatgt     2580

atctatctca ttttcttaca ccttctatta ccttctgctc tctctgattt ggaaaaagct     2640

gaaaaaaaag gttgaaacca gttccctgaa attattcccc tacttgacta ataagtatat     2700

aaagacggta ggtattgatt gtaattctgt aaatctattt cttaaacttc ttaaattcta     2760

cttttatagt tagtcttttt tttagtttta aaacaccaag aacttagttt cgaataaaca     2820

cacataaaca aacaaaatgc atatcagaaa cccatataga actccaattg actaccaagc     2880

tttgtctgaa gctttcccac cattgaagcc atttgtttcc gttaacgctg atggtacctc     2940

ctcagttgac ttgaccattc cagaagccca aagagctttt accgctgccc ttttgcacag     3000

agacttcggc ttgactatga ctatcccaga agatcgtttg tgtccaaccg ttccaaacag     3060

attgaactac gttttgtgga ttgaagacat tttcaactac accaacaaga ctttgggttt     3120

atctgacgac cgtccaatca agggtgttga tatcggtacc ggtgcttctg ccatttaccc     3180

aatgttggct tgcgccagat tcaaggcttg gtccatggtt ggtactgaag ttgaaagaaa     3240

gtgtatcgac actgctagat taaacgttgt tgctaacaac ttgcaagatc gtctatccat     3300

cttggaaacc tctattgacg gtccaatttt agtcccaatt ttcgaagcta ccgaagaata     3360

cgaatacgaa ttcaccatgt gtaacccacc tttctacgat ggtgccgctg acatgcaaac     3420

tagcgatgct gcaaagggtt ttggtttcgg tgtcggtgct ccacactctg gtacagtcat     3480

cgaaatgtct actgaaggtg gtgaatccgc tttcgtggct caaatggtta gagaatctct     3540

taagttgaga accagatgta gatggtacac ttctaactta ggtaagttga aatctttgaa     3600

ggaaattgtc ggtttgttga aggaattaga aatctctaat tacgccatca acgaatatgt     3660

ccaaggttcc actagaagat acgctgtcgc ttggagtttc actgatatcc aattgccaga     3720

agaattgtcc agaccatcta atcctgaatt gtcctctttg ttcgactaca aggatgacga     3780

tgacaaatga atcgcgtgca ttcatccgct ctaaccgaaa aggaaggagt tagacaacct     3840

gaagtctagg tccctattta tttttttata gttatgttag tattaagaac gttatttata     3900

tttcaaattt ttcttttttt tctgtacaga cgcgtgtacg catgtaacat tatactgaaa     3960

accttgcttg agaaggtttt gggacgctcg aagatcgcgt acccaattcg ccctatagtg     4020

agtcgtatta cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     4080

gcgttacccc tgcaggacta gtgctgaggc attaatgcaa ctcagaagtt tgacagcaag     4140

caagttcatc attcgaacta gccttattgt tttagttcag tgacagcgaa ctgccgtact     4200

cgatgcttta tttctcacgg tagagcggaa gaacagatag gggcagcgtg agaagagtta     4260

gaaagtaaat ttttatcacg tctgaagtat tcttattcat aggaaatttt gcaaggtttt     4320

ttagctcaat aacgggctaa gttatataag gtgttcacgc gattttcttg ttatgtatac     4380

ctcttctctg aggaatggta ctactgtcct gatgtaggct ccttaaattg gtgggcaaga     4440

ataacttatc gatattttgt atattggtct tggagttcac cacgtaatgc ctgtttaaga     4500

ccatcagtta actctagtat tatttggtct tggctactgg ccgtttgcta ttattcaagt     4560

cttttgtgcc ttcccgtcgg gtaagggagt tatttaggga tacagaatct aacgaaaact     4620

aaatctcaat gattaactct atttaatcct tttttgaaag gcaaaagagg tcccttgttc     4680

acttacaacg ttcttagcca aattcgctta tcacttacta cttcacgata tacagaagta     4740

aaaacatata aaaagatgtc tgtttgttta gccatcacaa aaggtatcgc ag             4792


<210>  76
<211>  9145
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  76
tgttttatat ttgttgtaaa aagtagataa ttacttcctt gatgatctgt aaaaaagaga       60

aaaagaaagc atctaagaac ttgaaaaact acgaattaga aaagaccaaa tatgtatttc      120

ttgcattgac caatttatgc aagtttatat atatgtaaat gtaagtttca cgaggttcta      180

ctaaactaaa ccaccccctt ggttagaaga aaagagtgtg tgagaacagg ctgttgttgt      240

cacacgattc ggacaattct gtttgaaaga gagagagtaa cagtacgatc gaacgaactt      300

tgctctggag atcacagtgg gcatcatagc atgtggtact aaaccctttc ccgccattcc      360

agaaccttcg attgcttgtt acaaaacctg tgagccgtcg ctaggacctt gttgtgtgac      420

gaaattggaa gctgcaatca ataggaagac aggaagtcga gcgtgtctgg gttttttcag      480

ttttgttctt tttgcaaaca acagtttatt cctggcatcc actaaatata atggagcccg      540

ctttttaagc tggcatccag aaaaaaaaag aatcccagca ccaaaatatt gttttcttca      600

ccaaccatca gttcataggt ccattctctt agcgcaacta cagagaacag gggcacaaac      660

aggcaaaaaa cgggcacaac ctcaatggag tgatgcaacc tgcctggagt aaatgatgac      720

acaaggcaat tgacccacgc atgtatctat ctcattttct tacaccttct attaccttct      780

gctctctctg atttggaaaa agctgaaaaa aaaggttgaa accagttccc tgaaattatt      840

cccctacttg actaataagt atataaagac ggtaggtatt gattgtaatt ctgtaaatct      900

atttcttaaa cttcttaaat tctactttta tagttagtct tttttttagt tttaaaacac      960

caagaactta gtttcgaata aacacacata aacaaacaaa ggatccatga tgaagttctg     1020

gagaaagtac acacaacaag aaatggatga aaagattact gaatctttgg aaaagacttt     1080

gaactacgat aacactaaga caatcggtat tccaggtact aagttggatg atacagtttt     1140

ctatgatgat cattctttcg ttaagcattc accatacttg agaactttta ttcaaaaccc     1200

aaaccatatc ggttgtcata cttatgataa ggctgatatc ttgttcggtg gtacattcga     1260

tatcgaaaga gaattaatcc aattgttagc aatcgatgtt ttgaacggta acgatgaaga     1320

atttgatggt tacgttactc aaggtggtac agaagctaac atccaagcaa tgtgggttta     1380

cagaaactac ttcaagaaag aaagaaaggc taagcatgaa gaaatcgcta tcatcacttc     1440

agcagataca cattactctg catacaaagg ttcagatttg ttgaacatcg atattattaa     1500

ggttccagtt gatttttatt caagaaaaat tcaagaaaat acattggatt caattgttaa     1560

agaagctaaa gaaattggta aaaagtactt catcgttatc tctaacatgg gtactacaat     1620

gtttggttca gttgatgatc cagatttgta cgctaacatc ttcgataagt acaatttgga     1680

atacaaaatt catgttgatg gtgcatttgg tggttttata tatccaattg ataataagga     1740

atgtaaaact gatttctcta ataagaacgt ttcttcaatc acattagatg gtcataagat     1800

gttgcaagct ccatacggta ctggtatctt cgtttcaaga aagaatttga tccataacac     1860

tttgacaaag gaagcaactt acatcgaaaa tttggatgtt acattgtctg gttcaagatc     1920

tggttcaaat gctgttgcaa tttggatggt tttagcttct tatggtccat acggttggat     1980

ggaaaagatt aataagttga gaaatagaac taaatggttg tgtaagcaat tgaacgatat     2040

gagaattaaa tattacaaag aagattcaat gaatattgtt acaattgaag aacaatatgt     2100

taataaggaa atcgctgaaa agtacttttt agttccagaa gttcataacc caactaacaa     2160

ctggtacaag atcgttgtta tggaacatgt tgaattggat atcttgaact ctttggttta     2220

cgatttgaga aagtttaata aggaacattt gaaggcaatg catcatcatc atcatcatta     2280

accgcggcta gctaagatcc gctctaaccg aaaaggaagg agttagacaa cctgaagtct     2340

aggtccctat ttattttttt atagttatgt tagtattaag aacgttattt atatttcaaa     2400

tttttctttt ttttctgtac agacgcgtgt acgcatgtaa cattatactg aaaaccttgc     2460

ttgagaaggt tttgggacgc tcgaagatcc agctgcatta atgaatcggc caacgcgcgg     2520

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     2580

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     2640

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     2700

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     2760

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     2820

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     2880

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     2940

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     3000

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     3060

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     3120

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg     3180

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     3240

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     3300

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     3360

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     3420

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     3480

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     3540

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     3600

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     3660

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     3720

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt     3780

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg     3840

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca     3900

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt     3960

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat     4020

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac     4080

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa     4140

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt     4200

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt     4260

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa     4320

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt     4380

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa     4440

taggggttcc gcgcacattt ccccgaaaag tgccacctga acgaagcatc tgtgcttcat     4500

tttgtagaac aaaaatgcaa cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc     4560

atttttacag aacagaaatg caacgcgaaa gcgctatttt accaacgaag aatctgtgct     4620

tcatttttgt aaaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca aagaatctga     4680

gctgcatttt tacagaacag aaatgcaacg cgagagcgct attttaccaa caaagaatct     4740

atacttcttt tttgttctac aaaaatgcat cccgagagcg ctatttttct aacaaagcat     4800

cttagattac tttttttctc ctttgtgcgc tctataatgc agtctcttga taactttttg     4860

cactgtaggt ccgttaaggt tagaagaagg ctactttggt gtctattttc tcttccataa     4920

aaaaagcctg actccacttc ccgcgtttac tgattactag cgaagctgcg ggtgcatttt     4980

ttcaagataa aggcatcccc gattatattc tataccgatg tggattgcgc atactttgtg     5040

aacagaaagt gatagcgttg atgattcttc attggtcaga aaattatgaa cggtttcttc     5100

tattttgtct ctatatacta cgtataggaa atgtttacat tttcgtattg ttttcgattc     5160

actctatgaa tagttcttac tacaattttt ttgtctaaag agtaatacta gagataaaca     5220

taaaaaatgt agaggtcgag tttagatgca agttcaagga gcgaaaggtg gatgggtagg     5280

ttatataggg atatagcaca gagatatata gcaaagagat acttttgagc aatgtttgtg     5340

gaagcggtat tcgcaatatt ttagtagctc gttacagtcc ggtgcgtttt tggttttttg     5400

aaagtgcgtc ttcagagcgc ttttggtttt caaaagcgct ctgaagttcc tatactttct     5460

agagaatagg aacttcggaa taggaacttc aaagcgtttc cgaaaacgag cgcttccgaa     5520

aatgcaacgc gagctgcgca catacagctc actgttcacg tcgcacctat atctgcgtgt     5580

tgcctgtata tatatataca tgagaagaac ggcatagtgc gtgtttatgc ttaaatgcgt     5640

acttatatgc gtctatttat gtaggatgaa aggtagtcta gtacctcctg tgatattatc     5700

ccattccatg cggggtatcg tatgcttcct tcagcactac cctttagctg ttctatatgc     5760

tgccactcct caattggatt agtctcatcc ttcaatgcta tcatttcctt tgatattgga     5820

tcatactaag aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg     5880

ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg     5940

gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg     6000

tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta     6060

ctgagagtgc accatatttc acaccgcata gatccgtcga gttcaagaga aaaaaaaaga     6120

aaaagcaaaa agaaaaaagg aaagcgcgcc tcgttcagaa tgacacgtat agaatgatgc     6180

attaccttgt catcttcagt atcatactgt tcgtatacat acttactgac attcataggt     6240

atacatatat acacatgtat atatatcgta tgctgcagct ttaaataatc ggtgtcacta     6300

cataagaaca cctttggtgg agggaacatc gttggtacca ttgggcgagg tggcttctct     6360

tatggcaacc gcaagagcct tgaacgcact ctcactacgg tgatgatcat tcttgcctcg     6420

cagacaatca acgtggaggg taattctgct agcctctgca aagctttcaa gaaaatgcgg     6480

gatcatctcg caagagagat ctcctacttt ctccctttgc aaaccaagtt cgacaactgc     6540

gtacggcctg ttcgaaagat ctaccaccgc tctggaaagt gcctcatcca aaggcgcaaa     6600

tcctgatcca aaccttttta ctccacgcac ggcccctagg gcctctttaa aagcttgacc     6660

gagagcaatc ccgcagtctt cagtggtgtg atggtcgtct atgtgtaagt caccaatgca     6720

ctcaacgatt agcgaccagc cggaatgctt ggccagagca tgtatcatat ggtccagaaa     6780

ccctatacct gtgtggacgt taatcacttg cgattgtgtg gcctgttctg ctactgcttc     6840

tgcctctttt tctgggaaga tcgagtgctc tatcgctagg ggaccaccct ttaaagagat     6900

cgcaatctga atcttggttt catttgtaat acgctttact agggctttct gctctgtcat     6960

ctttgccttc gtttatcttg cctgctcatt ttttagtata ttcttcgaag aaatcacatt     7020

actttatata atgtataatt cattatgtga taatgccaat cgctaagaaa aaaaaagagt     7080

catccgctag gtggaaaaaa aaaaatgaaa atcattaccg aggcataaaa aaatatagag     7140

tgtactagag gaggccaaga gtaatagaaa aagaaaattg cgggaaagga ctgtgttatg     7200

acttccctga ctaatgccgt gttcaaacga tacctggcag tgactcctag cgctcaccaa     7260

gctcttaaaa cgggaattta tggtgcactc tcagtacacg cgccagatct gtttagcttg     7320

cctcgtcccc gccgggtcac ccggccagcg acatggaggc ccagaatacc ctccttgaca     7380

gtcttgacgt gcgcagctca ggggcatgat gtgactgtcg cccgtacatt tagcccatac     7440

atccccatgt ataatcattt gcatccatac attttgatgg ccgcacggcg cgaagcaaaa     7500

attacggctc ctcgctgcag acctgcgagc agggaaacgc tcccctcaca gacgcgttga     7560

attgtcccca cgccgcgccc ctgtagagaa atataaaagg ttaggatttg ccactgaggt     7620

tcttctttca tatacttcct tttaaaatct tgctaggata cagttctcac atcacatccg     7680

aacataaaca accatgggta aggaaaagac tcacgtttcg aggccgcgat taaattccaa     7740

catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc aatcaggtgc     7800

gacaatctat cgattgtatg ggaagcccga tgcgccagag ttgtttctga aacatggcaa     7860

aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc tgacggaatt     7920

tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat ggttactcac     7980

cactgcgatc cccggcaaaa cagcattcca ggtattagaa gaatatcctg attcaggtga     8040

aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc ctgtttgtaa     8100

ttgtcctttt aacagcgatc gcgtatttcg tctcgctcag gcgcaatcac gaatgaataa     8160

cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg ttgaacaagt     8220

ctggaaagaa atgcataagc ttttgccatt ctcaccggat tcagtcgtca ctcatggtga     8280

tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta ttgatgttgg     8340

acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact gcctcggtga     8400

gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata atcctgatat     8460

gaataaattg cagtttcatt tgatgctcga tgagtttttc taatcagtac tgacaataaa     8520

aagattcttg ttttcaagaa cttgtcattt gtatagtttt tttatattgt agttgttcta     8580

ttttaatcaa atgttagcgt gatttatatt ttttttcgcc tcgacatcat ctgcccagat     8640

gcgaagttaa gtgcgcagaa agtaatatca tgcgtcaatc gtatgtgaat gctggtcgct     8700

atactgctgt cgattcgata ctaacgccgc catccagtgt cgaattcgcc attcaggctg     8760

cgcaactgtt gggaagggcg atcggtgcgg gcctcttcgc tattacgcca gctgaattgg     8820

agcgacctca tgctatacct gagaaagcaa cctgacctac aggaaagagt tactcaagaa     8880

taagaatttt cgttttaaaa cctaagagtc actttaaaat ttgtatacac ttattttttt     8940

tataacttat ttaataataa aaatcataaa tcataagaaa ttcgcttatt tagaagtgtc     9000

aacaacgtat ctaccaacga tttgaccctt ttccatcttt tcgtaaattt ctggcaaggt     9060

agacaagccg acaaccttga ttggagactt gaccaaacct ctggcgaaga attgttaatt     9120

aagagctcag atcttttgcg gccgc                                           9145


<210>  77
<211>  499
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  77
gtttgcaaaa agaacaaaac tgaaaaaacc cagacacgct cgacttcctg tcttcctatt       60

gattgcagct tccaatttcg tcacacaaca aggtcctagc gacggctcac aggttttgta      120

acaagcaatc gaaggttctg gaatggcggg aaagggttta gtaccacatg ctatgatgcc      180

cactgtgatc tccagagcaa agttcgttcg atcgtactgt tactctctct ctttcaaaca      240

gaattgtccg aatcgtgtga caacaacagc ctgttctcac acactctttt cttctaacca      300

agggggtggt ttagtttagt agaacctcgt gaaacttaca tttacatata tataaacttg      360

cataaattgg tcaatgcaag aaatacatat ttggtctttt ctaattcgta gtttttcaag      420

ttcttagatg ctttcttttt ctctttttta cagatcatca aggaagtaat tatctacttt      480

ttacaacaaa tataaaaca                                                   499


<210>  78
<211>  500
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  78
acagtttatt cctggcatcc actaaatata atggagcccg ctttttaagc tggcatccag       60

aaaaaaaaag aatcccagca ccaaaatatt gttttcttca ccaaccatca gttcataggt      120

ccattctctt agcgcaacta cagagaacag gggcacaaac aggcaaaaaa cgggcacaac      180

ctcaatggag tgatgcaacc tgcctggagt aaatgatgac acaaggcaat tgacccacgc      240

atgtatctat ctcattttct tacaccttct attaccttct gctctctctg atttggaaaa      300

agctgaaaaa aaaggttgaa accagttccc tgaaattatt cccctacttg actaataagt      360

atataaagac ggtaggtatt gattgtaatt ctgtaaatct atttcttaaa cttcttaaat      420

tctactttta tagttagtct tttttttagt tttaaaacac caagaactta gtttcgaata      480

aacacacata aacaaacaaa                                                  500


<210>  79
<211>  500
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  79
gctggattga gctgaatggt gccaggtcga ggctgggagg gagactaact cgaaagtgac       60

gaagactcga aaattaaaaa aaaagatact gcagaaggca agattgagaa tggagtaaag      120

gcagcgtggg tcccctgtgg aaaccgcagt tttcctgcgc caagtggtac cggtgcgagt      180

gcagcaatta atctctcgat attttcttag tatctctttt tatataagaa tatattttgg      240

aattggtaat gcttatcttc aatagtttct tagttgaatg cacacttaag agcaaattgg      300

ccaaggagtt cttcgttcgc tttaatttat ttcctggtta ttgtcaattt attcatccca      360

tctccccagg atagaagaaa ttagtgtaat tttgctgaca atacatttta acgacgataa      420

caataatagc aattaaataa aatagcacta ccaccactcc actgctcgtt agctatttct      480

gtaaaataaa taaaaagatc                                                  500


<210>  80
<211>  501
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  80
attcgcgcta tctcgatttc tacctatata gttaatctct gtacaaaaac aatctttcca       60

actatccatt aatcatagta tattatcagc gtcggcgatt ttaccacgct tgacaaaagc      120

cgcgggcggg attcctgtgg gtagtggcac cggcagttaa tctaatcaaa ggcgcttgaa      180

ggaagagata gataatagaa caaagcaatc gccgctttgg acggcaaata tgtttatcca      240

ttggtgcggt gattggatat gatttgtctc cagtagtata agcaagcgcc agatctgttt      300

actgtaaaat taagtgagta atctcgcggg atgtaatgat ttaagggaat ctggttcagg      360

ttttcacata tatttgtata taaggccatt tgtaatttca atagttttag gatttttcct      420

tctcccaaaa tactcactta ctgtgttaca ttacagaaag aacagacaag aaaccgtcaa      480

taagaaatat aactaagaac a                                                501


<210>  81
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic HA epitope tag polypeptide

<400>  81
tacccatacg acgttccaga ctacgcc                                           27


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HA epitope tag polypeptide

<400>  82

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  83
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic c-MYC epitope tag polypeptide

<400>  83
gaacaaaagt taatttctga agaagatttg gaa                                    33


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic c-MYC epitope tag polypeptide

<400>  84

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  85
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic FLAG epitope tag polypeptide

<400>  85
gactacaagg atgacgatga caaa                                              24


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic FLAG epitope tag polypeptide

<400>  86

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  87
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic V5 epitope tag polypeptide

<400>  87
ggtaagccaa ttccaaatcc tttgttgggt ttggactcca cc                          42


<210>  88
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic V5 epitope tag polypeptide

<400>  88

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  89
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic HIS epitope tag polypeptide

<400>  89
catcatcatc atcatcat                                                     18


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HIS epitope tag polypeptide

<400>  90

His His His His His His 
1               5       


<210>  91
<211>  7882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMM1 vector

<400>  91
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gatcttcgag cgtcccaaaa ccttctcaag caaggttttc agtataatgt     2040

tacatgcgta cacgcgtctg tacagaaaaa aaagaaaaat ttgaaatata aataacgttc     2100

ttaatactaa cataactata aaaaaataaa tagggaccta gacttcaggt tgtctaactc     2160

cttccttttc ggttagagcg gatcttagct agccgcggta ccaagctggt ggatcctttg     2220

tttgtttatg tgtgtttatt cgaaactaag ttcttggtgt tttaaaacta aaaaaaagac     2280

taactataaa agtagaattt aagaagttta agaaatagat ttacagaatt acaatcaata     2340

cctaccgtct ttatatactt attagtcaag taggggaata atttcaggga actggtttca     2400

accttttttt tcagcttttt ccaaatcaga gagagcagaa ggtaatagaa ggtgtaagaa     2460

aatgagatag atacatgcgt gggtcaattg ccttgtgtca tcatttactc caggcaggtt     2520

gcatcactcc attgaggttg tgcccgtttt ttgcctgttt gtgcccctgt tctctgtagt     2580

tgcgctaaga gaatggacct atgaactgat ggttggtgaa gaaaacaata ttttggtgct     2640

gggattcttt ttttttctgg atgccagctt aaaaagcggg ctccattata tttagtggat     2700

gccaggaata aactgttgtt tgcaaaaaga acaaaactga aaaaacccag acacgctcga     2760

cttcctgtct tcctattgat tgcagcttcc aatttcgtca cacaacaagg tcctagcgac     2820

ggctcacagg ttttgtaaca agcaatcgaa ggttctggaa tggcgggaaa gggtttagta     2880

ccacatgcta tgatgcccac tgtgatctcc agagcaaagt tcgttcgatc gtactgttac     2940

tctctctctt tcaaacagaa ttgtccgaat cgtgtgacaa caacagcctg ttctcacaca     3000

ctcttttctt ctaaccaagg gggtggttta gtttagtaga acctcgtgaa acttacattt     3060

acatatatat aaacttgcat aaattggtca atgcaagaaa tacatatttg gtcttttcta     3120

attcgtagtt tttcaagttc ttagatgctt tctttttctc ttttttacag atcatcaagg     3180

aagtaattat ctacttttta caacaaatat aaaacagcgg ccgcaaaaga tctgagctct     3240

taattaacaa ttcttcgcca gaggtttggt caagtctcca atcaaggttg tcggcttgtc     3300

taccttgcca gaaatttacg aaaagatgga aaagggtcaa atcgttggta gatacgttgt     3360

tgacacttct aaataagcga atttcttatg atttatgatt tttattatta aataagttat     3420

aaaaaaaata agtgtataca aattttaaag tgactcttag gttttaaaac gaaaattctt     3480

attcttgagt aactctttcc tgtaggtcag gttgctttct caggtatagc atgaggtcgc     3540

tccaattcag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc     3600

gcagcctgaa tggcgaattc gacactggat ggcggcgtta gtatcgaatc gacagcagta     3660

tagcgaccag cattcacata cgattgacgc atgatattac tttctgcgca cttaacttcg     3720

catctgggca gatgatgtcg aggcgaaaaa aaatataaat cacgctaaca tttgattaaa     3780

atagaacaac tacaatataa aaaaactata caaatgacaa gttcttgaaa acaagaatct     3840

ttttattgtc agtactgatt agaaaaactc atcgagcatc aaatgaaact gcaatttatt     3900

catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa     3960

ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg     4020

tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa     4080

atcaccatga gtgacgactg aatccggtga gaatggcaaa agcttatgca tttctttcca     4140

gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc     4200

gttattcatt cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt taaaaggaca     4260

attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt     4320

ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttgccgg ggatcgcagt     4380

ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat     4440

aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc     4500

tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt     4560

cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat     4620

gttggaattt aatcgcggcc tcgaaacgtg agtcttttcc ttacccatgg ttgtttatgt     4680

tcggatgtga tgtgagaact gtatcctagc aagattttaa aaggaagtat atgaaagaag     4740

aacctcagtg gcaaatccta accttttata tttctctaca ggggcgcggc gtggggacaa     4800

ttcaacgcgt ctgtgagggg agcgtttccc tgctcgcagg tctgcagcga ggagccgtaa     4860

tttttgcttc gcgccgtgcg gccatcaaaa tgtatggatg caaatgatta tacatgggga     4920

tgtatgggct aaatgtacgg gcgacagtca catcatgccc ctgagctgcg cacgtcaaga     4980

ctgtcaagga gggtattctg ggcctccatg tcgctggccg ggtgacccgg cggggacgag     5040

gcaagctaaa cagatctggc gcgtgtactg agagtgcacc ataaattccc gttttaagag     5100

cttggtgagc gctaggagtc actgccaggt atcgtttgaa cacggcatta gtcagggaag     5160

tcataacaca gtcctttccc gcaattttct ttttctatta ctcttggcct cctctagtac     5220

actctatatt tttttatgcc tcggtaatga ttttcatttt tttttttcca cctagcggat     5280

gactcttttt ttttcttagc gattggcatt atcacataat gaattataca ttatataaag     5340

taatgtgatt tcttcgaaga atatactaaa aaatgagcag gcaagataaa cgaaggcaaa     5400

gatgacagag cagaaagccc tagtaaagcg tattacaaat gaaaccaaga ttcagattgc     5460

gatctcttta aagggtggtc ccctagcgat agagcactcg atcttcccag aaaaagaggc     5520

agaagcagta gcagaacagg ccacacaatc gcaagtgatt aacgtccaca caggtatagg     5580

gtttctggac catatgatac atgctctggc caagcattcc ggctggtcgc taatcgttga     5640

gtgcattggt gacttacaca tagacgacca tcacaccact gaagactgcg ggattgctct     5700

cggtcaagct tttaaagagg ccctaggggc cgtgcgtgga gtaaaaaggt ttggatcagg     5760

atttgcgcct ttggatgagg cactttccag agcggtggta gatctttcga acaggccgta     5820

cgcagttgtc gaacttggtt tgcaaaggga gaaagtagga gatctctctt gcgagatgat     5880

cccgcatttt cttgaaagct ttgcagaggc tagcagaatt accctccacg ttgattgtct     5940

gcgaggcaag aatgatcatc accgtagtga gagtgcgttc aaggctcttg cggttgccat     6000

aagagaagcc acctcgccca atggtaccaa cgatgttccc tccaccaaag gtgttcttat     6060

gtagtgacac cgattattta aagctgcagc atacgatata tatacatgtg tatatatgta     6120

tacctatgaa tgtcagtaag tatgtatacg aacagtatga tactgaagat gacaaggtaa     6180

tgcatcattc tatacgtgtc attctgaacg aggcgcgctt tccttttttc tttttgcttt     6240

ttcttttttt ttctcttgaa ctcgacggat ctatgcggtg tgaaatatgg tgcactctca     6300

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg     6360

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     6420

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     6480

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagtatg     6540

atccaatatc aaaggaaatg atagcattga aggatgagac taatccaatt gaggagtggc     6600

agcatataga acagctaaag ggtagtgctg aaggaagcat acgatacccc gcatggaatg     6660

ggataatatc acaggaggta ctagactacc tttcatccta cataaataga cgcatataag     6720

tacgcattta agcataaaca cgcactatgc cgttcttctc atgtatatat atatacaggc     6780

aacacgcaga tataggtgcg acgtgaacag tgagctgtat gtgcgcagct cgcgttgcat     6840

tttcggaagc gctcgttttc ggaaacgctt tgaagttcct attccgaagt tcctattctc     6900

tagaaagtat aggaacttca gagcgctttt gaaaaccaaa agcgctctga agacgcactt     6960

tcaaaaaacc aaaaacgcac cggactgtaa cgagctacta aaatattgcg aataccgctt     7020

ccacaaacat tgctcaaaag tatctctttg ctatatatct ctgtgctata tccctatata     7080

acctacccat ccacctttcg ctccttgaac ttgcatctaa actcgacctc tacatttttt     7140

atgtttatct ctagtattac tctttagaca aaaaaattgt agtaagaact attcatagag     7200

tgaatcgaaa acaatacgaa aatgtaaaca tttcctatac gtagtatata gagacaaaat     7260

agaagaaacc gttcataatt ttctgaccaa tgaagaatca tcaacgctat cactttctgt     7320

tcacaaagta tgcgcaatcc acatcggtat agaatataat cggggatgcc tttatcttga     7380

aaaaatgcac ccgcagcttc gctagtaatc agtaaacgcg ggaagtggag tcaggctttt     7440

tttatggaag agaaaataga caccaaagta gccttcttct aaccttaacg gacctacagt     7500

gcaaaaagtt atcaagagac tgcattatag agcgcacaaa ggagaaaaaa agtaatctaa     7560

gatgctttgt tagaaaaata gcgctctcgg gatgcatttt tgtagaacaa aaaagaagta     7620

tagattcttt gttggtaaaa tagcgctctc gcgttgcatt tctgttctgt aaaaatgcag     7680

ctcagattct ttgtttgaaa aattagcgct ctcgcgttgc atttttgttt tacaaaaatg     7740

aagcacagat tcttcgttgg taaaatagcg ctttcgcgtt gcatttctgt tctgtaaaaa     7800

tgcagctcag attctttgtt tgaaaaatta gcgctctcgc gttgcatttt tgttctacaa     7860

aatgaagcac agatgcttcg tt                                              7882


<210>  92
<211>  3810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDM4 vector

<400>  92
gctaacagcg cgatttgctg gtgacccaat gcgaccagat gctccacgcc cagtcgcgta       60

ccgtcttcat gggagaaaat aatactgttg atgggtgtct ggtcagagac atcaagaaat      120

aacgccggaa cattagtgca ggcagcttcc acagcaatgg catcctggtc atccagcgga      180

tagttaatga tcagcccact gacgcgttgc gcgagaagat tgtgcaccgc cgctttacag      240

gcttcgacgc cgcttcgttc taccatcgac accaccacgc tggcacccag ttgatcggcg      300

cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca gggccagact ggaggtggca      360

acgccaatca gcaacgactg tttgcccgcc agttgttgtg ccacgcggtt gggaatgtaa      420

ttcagctccg ccatcgccgc ttccactttt tcccgcgttt tcgcagaaac gtggctggcc      480

tggttcacca cgcgggaaac ggtctgataa gagacaccgg catactctgc gacatcgtat      540

aacgttactg gtttcacatt caccaccctg aattgactct cttccgggcg ctatcatgcc      600

ataccgcgaa aggttttgcg ccattcgatg gtgtccggga tctcgacgct ctcccttatg      660

cgactcctgc attaggaagc agcccagtag taggttgagg ccgttgagca ccgccgccgc      720

aaggaatggt gcatgcaagg agatggcgcc caacagtccc ccggccacgg ggcctgccac      780

catacccacg ccgaaacaag cgctcatgag cccgaagtgg cgagcccgat cttccccatc      840

ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg gcgccggtga tgccggccac      900

gatgcgtccg gcgtagccta ggatcgagat cgatctcgat cccgcgaaat taatacgact      960

cactataggg gaattgtgag cggataacaa ttcccctcta gaaataattt tgtttaactt     1020

taagaaggag atatacatat ggcagatctc aattggatat cggccggcca cgcgatcgct     1080

gacgtcggta ccctcgagtc tggtaaagaa accgctgctg cgaaatttga acgccagcac     1140

atggactcgt ctactagtcg cagcttaatt aacctaaact gctgccaccg ctgagcaata     1200

actagcataa ccccttgggg cctctaaacg ggtcttgagg ggttttttgc tagcgaaagg     1260

aggagtcgac actgcttccg gtagtcaata aaccggtaaa ccagcaatag acataagcgg     1320

ctatttaacg accctgccct gaaccgacga ccgggtcatc gtggccggat cttgcggccc     1380

ctcggcttga acgaattgtt agacattatt tgccgactac cttggtgatc tcgcctttca     1440

cgtagtggac aaattcttcc aactgatctg cgcgcgaggc caagcgatct tcttcttgtc     1500

caagataagc ctgtctagct tcaagtatga cgggctgata ctgggccggc aggcgctcca     1560

ttgcccagtc ggcagcgaca tccttcggcg cgattttgcc ggttactgcg ctgtaccaaa     1620

tgcgggacaa cgtaagcact acatttcgct catcgccagc ccagtcgggc ggcgagttcc     1680

atagcgttaa ggtttcattt agcgcctcaa atagatcctg ttcaggaacc ggatcaaaga     1740

gttcctccgc cgctggacct accaaggcaa cgctatgttc tcttgctttt gtcagcaaga     1800

tagccagatc aatgtcgatc gtggctggct cgaagatacc tgcaagaatg tcattgcgct     1860

gccattctcc aaattgcagt tcgcgcttag ctggataacg ccacggaatg atgtcgtcgt     1920

gcacaacaat ggtgacttct acagcgcgga gaatctcgct ctctccaggg gaagccgaag     1980

tttccaaaag gtcgttgatc aaagctcgcc gcgttgtttc atcaagcctt acggtcaccg     2040

taaccagcaa atcaatatca ctgtgtggct tcaggccgcc atccactgcg gagccgtaca     2100

aatgtacggc cagcaacgtc ggttcgagat ggcgctcgat gacgccaact acctctgata     2160

gttgagtcga tacttcggcg atcaccgctt ccctcatact cttccttttt caatattatt     2220

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     2280

ataaacaaat agccagctca ctcggtcgct acgctccggg cgtgagactg cggcgggcgc     2340

tgcggacaca tacaaagtta cccacagatt ccgtggataa gcaggggact aacatgtgag     2400

gcaaaacagc agggccgcgc cggtggcgtt tttccatagg ctccgccctc ctgccagagt     2460

tcacataaac agacgctttt ccggtgcatc tgtgggagcc gtgaggctca accatgaatc     2520

tgacagtacg ggcgaaaccc gacaggactt aaagatcccc accgtttccg gcgggtcgct     2580

ccctcttgcg ctctcctgtt ccgaccctgc cgtttaccgg atacctgttc cgcctttctc     2640

ccttacggga agtgtggcgc tttctcatag ctcacacact ggtatctcgg ctcggtgtag     2700

gtcgttcgct ccaagctggg ctgtaagcaa gaactccccg ttcagcccga ctgctgcgcc     2760

ttatccggta actgttcact tgagtccaac ccggaaaagc acggtaaaac gccactggca     2820

gcagccattg gtaactggga gttcgcagag gatttgttta gctaaacacg cggttgctct     2880

tgaagtgtgc gccaaagtcc ggctacactg gaaggacaga tttggttgct gtgctctgcg     2940

aaagccagtt accacggtta agcagttccc caactgactt aaccttcgat caaaccacct     3000

ccccaggtgg ttttttcgtt tacagggcaa aagattacgc gcagaaaaaa aggatctcaa     3060

gaagatcctt tgatcttttc tactgaaccg ctctagattt cagtgcaatt tatctcttca     3120

aatgtagcac ctgaagtcag ccccatacga tataagttgt aattctcatg ttagtcatgc     3180

cccgcgccca ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc     3240

ccggtgccta atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc     3300

agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg     3360

gtttgcgtat tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga     3420

ttgcccttca ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc     3480

agcaggcgaa aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg     3540

gtatcgtcgt atcccactac cgagatgtcc gcaccaacgc gcagcccgga ctcggtaatg     3600

gcgcgcattg cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg     3660

ccctcattca gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc     3720

cgttccgcta tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc     3780

agacgcgccg agacagaact taatgggccc                                      3810


<210>  93
<211>  5203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pETM6 vector

<400>  93
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag       60

gagatataca tatggcagat ctcaattgga tatcggccgg ccacgcgatc gctgacgtcg      120

gtaccctcga gtctggtaaa gaaaccgctg ctgcgaaatt tgaacgccag cacatggact      180

cgtctactag tcgcagctta attaacctaa actgctgcca ccgctgagca ataactagca      240

taaccccttg gggcctctaa acgggtcttg aggggttttt tgctagcgaa aggaggagtc      300

gactatatcc ggattggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt      360

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc      420

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg      480

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat      540

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg      600

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct      660

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa      720

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt      780

tctggcggca cgatggcatg agattatcaa aaaggatctt cacctagatc cttttaaatt      840

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc      900

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg      960

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     1020

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     1080

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     1140

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     1200

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     1260

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     1320

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     1380

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     1440

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     1500

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     1560

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     1620

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     1680

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     1740

aatgttgaat actcatactc ttcctttttc aatcatgatt gaagcattta tcagggttat     1800

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggtcatgac     1860

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1920

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1980

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     2040

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     2100

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     2160

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     2220

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     2280

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2340

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2400

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2460

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2520

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2580

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2640

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2700

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2760

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2820

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2880

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2940

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     3000

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     3060

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     3120

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     3180

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     3240

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3300

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3360

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3420

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3480

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3540

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgctag     3600

tcatgccccg cgcccaccgg aaggagctga ctgggttgaa ggctctcaag ggcatcggtc     3660

gagatcccgg tgcctaatga gtgagctaac ttacattaat tgcgttgcgc tcactgcccg     3720

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     3780

gaggcggttt gcgtattggg cgccagggtg gtttttcttt tcaccagtga gacgggcaac     3840

agctgattgc ccttcaccgc ctggccctga gagagttgca gcaagcggtc cacgctggtt     3900

tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg gcgggatata acatgagctg     3960

tcttcggtat cgtcgtatcc cactaccgag atgtccgcac caacgcgcag cccggactcg     4020

gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg caaccagcat cgcagtggga     4080

acgatgccct cattcagcat ttgcatggtt tgttgaaaac cggacatggc actccagtcg     4140

ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga gatatttatg ccagccagcc     4200

agacgcagac gcgccgagac agaacttaat gggcccgcta acagcgcgat ttgctggtga     4260

cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt cttcatggga gaaaataata     4320

ctgttgatgg gtgtctggtc agagacatca agaaataacg ccggaacatt agtgcaggca     4380

gcttccacag caatggcatc ctggtcatcc agcggatagt taatgatcag cccactgacg     4440

cgttgcgcga gaagattgtg caccgccgct ttacaggctt cgacgccgct tcgttctacc     4500

atcgacacca ccacgctggc acccagttga tcggcgcgag atttaatcgc cgcgacaatt     4560

tgcgacggcg cgtgcagggc cagactggag gtggcaacgc caatcagcaa cgactgtttg     4620

cccgccagtt gttgtgccac gcggttggga atgtaattca gctccgccat cgccgcttcc     4680

actttttccc gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg ggaaacggtc     4740

tgataagaga caccggcata ctctgcgaca tcgtataacg ttactggttt cacattcacc     4800

accctgaatt gactctcttc cgggcgctat catgccatac cgcgaaaggt tttgcgccat     4860

tcgatggtgt ccgggatctc gacgctctcc cttatgcgac tcctgcatta ggaagcagcc     4920

cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg aatggtgcat gcaaggagat     4980

ggcgcccaac agtcccccgg ccacggggcc tgccaccata cccacgccga aacaagcgct     5040

catgagcccg aagtggcgag cccgatcttc cccatcggtg atgtcggcga tataggcgcc     5100

agcaaccgca cctgtggcgc cggtgatgcc ggccacgatg cgtccggcgt agcctaggat     5160

cgagatcgat ctcgatcccg cgaaattaat acgactcact ata                       5203


<210>  94
<211>  5369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET28a(+) vector

<400>  94
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttgt      180

cgacggagct cgaattcgga tccgcgaccc atttgctgtc caccagtcat gctagccata      240

tggctgccgc gcggcaccag gccgctgctg tgatgatgat gatgatggct gctgcccatg      300

gtatatctcc ttcttaaagt taaacaaaat tatttctaga ggggaattgt tatccgctca      360

caattcccct atagtgagtc gtattaattt cgcgggatcg agatctcgat cctctacgcc      420

ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc      480

gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc      540

gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc cttgcatgca      600

ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg cttcctaatg      660

caggagtcgc ataagggaga gcgtcgagat cccggacacc atcgaatggc gcaaaacctt      720

tcgcggtatg gcatgatagc gcccggaaga gagtcaattc agggtggtga atgtgaaacc      780

agtaacgtta tacgatgtcg cagagtatgc cggtgtctct tatcagaccg tttcccgcgt      840

ggtgaaccag gccagccacg tttctgcgaa aacgcgggaa aaagtggaag cggcgatggc      900

ggagctgaat tacattccca accgcgtggc acaacaactg gcgggcaaac agtcgttgct      960

gattggcgtt gccacctcca gtctggccct gcacgcgccg tcgcaaattg tcgcggcgat     1020

taaatctcgc gccgatcaac tgggtgccag cgtggtggtg tcgatggtag aacgaagcgg     1080

cgtcgaagcc tgtaaagcgg cggtgcacaa tcttctcgcg caacgcgtca gtgggctgat     1140

cattaactat ccgctggatg accaggatgc cattgctgtg gaagctgcct gcactaatgt     1200

tccggcgtta tttcttgatg tctctgacca gacacccatc aacagtatta ttttctccca     1260

tgaagacggt acgcgactgg gcgtggagca tctggtcgca ttgggtcacc agcaaatcgc     1320

gctgttagcg ggcccattaa gttctgtctc ggcgcgtctg cgtctggctg gctggcataa     1380

atatctcact cgcaatcaaa ttcagccgat agcggaacgg gaaggcgact ggagtgccat     1440

gtccggtttt caacaaacca tgcaaatgct gaatgagggc atcgttccca ctgcgatgct     1500

ggttgccaac gatcagatgg cgctgggcgc aatgcgcgcc attaccgagt ccgggctgcg     1560

cgttggtgcg gatatctcgg tagtgggata cgacgatacc gaagacagct catgttatat     1620

cccgccgtta accaccatca aacaggattt tcgcctgctg gggcaaacca gcgtggaccg     1680

cttgctgcaa ctctctcagg gccaggcggt gaagggcaat cagctgttgc ccgtctcact     1740

ggtgaaaaga aaaaccaccc tggcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     1800

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca     1860

acgcaattaa tgtaagttag ctcactcatt aggcaccggg atctcgaccg atgcccttga     1920

gagccttcaa cccagtcagc tccttccggt gggcgcgggg catgactatc gtcgccgcac     1980

ttatgactgt cttctttatc atgcaactcg taggacaggt gccggcagcg ctctgggtca     2040

ttttcggcga ggaccgcttt cgctggagcg cgacgatgat cggcctgtcg cttgcggtat     2100

tcggaatctt gcacgccctc gctcaagcct tcgtcactgg tcccgccacc aaacgtttcg     2160

gcgagaagca ggccattatc gccggcatgg cggccccacg ggtgcgcatg atcgtgctcc     2220

tgtcgttgag gacccggcta ggctggcggg gttgccttac tggttagcag aatgaatcac     2280

cgatacgcga gcgaacgtga agcgactgct gctgcaaaac gtctgcgacc tgagcaacaa     2340

catgaatggt cttcggtttc cgtgtttcgt aaagtctgga aacgcggaag tcagcgccct     2400

gcaccattat gttccggatc tgcatcgcag gatgctgctg gctaccctgt ggaacaccta     2460

catctgtatt aacgaagcgc tggcattgac cctgagtgat ttttctctgg tcccgccgca     2520

tccataccgc cagttgttta ccctcacaac gttccagtaa ccgggcatgt tcatcatcag     2580

taacccgtat cgtgagcatc ctctctcgtt tcatcggtat cattaccccc atgaacagaa     2640

atccccctta cacggaggca tcagtgacca aacaggaaaa aaccgccctt aacatggccc     2700

gctttatcag aagccagaca ttaacgcttc tggagaaact caacgagctg gacgcggatg     2760

aacaggcaga catctgtgaa tcgcttcacg accacgctga tgagctttac cgcagctgcc     2820

tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     2880

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg     2940

ttggcgggtg tcggggcgca gccatgaccc agtcacgtag cgatagcgga gtgtatactg     3000

gcttaactat gcggcatcag agcagattgt actgagagtg caccatatat gcggtgtgaa     3060

ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc     3120

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     3180

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     3240

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     3300

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     3360

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     3420

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     3480

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     3540

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     3600

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     3660

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     3720

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     3780

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     3840

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     3900

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgaa caataaaact     3960

gtctgcttac ataaacagta atacaagggg tgttatgagc catattcaac gggaaacgtc     4020

ttgctctagg ccgcgattaa attccaacat ggatgctgat ttatatgggt ataaatgggc     4080

tcgcgataat gtcgggcaat caggtgcgac aatctatcga ttgtatggga agcccgatgc     4140

gccagagttg tttctgaaac atggcaaagg tagcgttgcc aatgatgtta cagatgagat     4200

ggtcagacta aactggctga cggaatttat gcctcttccg accatcaagc attttatccg     4260

tactcctgat gatgcatggt tactcaccac tgcgatcccc gggaaaacag cattccaggt     4320

attagaagaa tatcctgatt caggtgaaaa tattgttgat gcgctggcag tgttcctgcg     4380

ccggttgcat tcgattcctg tttgtaattg tccttttaac agcgatcgcg tatttcgtct     4440

cgctcaggcg caatcacgaa tgaataacgg tttggttgat gcgagtgatt ttgatgacga     4500

gcgtaatggc tggcctgttg aacaagtctg gaaagaaatg cataaacttt tgccattctc     4560

accggattca gtcgtcactc atggtgattt ctcacttgat aaccttattt ttgacgaggg     4620

gaaattaata ggttgtattg atgttggacg agtcggaatc gcagaccgat accaggatct     4680

tgccatccta tggaactgcc tcggtgagtt ttctccttca ttacagaaac ggctttttca     4740

aaaatatggt attgataatc ctgatatgaa taaattgcag tttcatttga tgctcgatga     4800

gtttttctaa gaattaattc atgagcggat acatatttga atgtatttag aaaaataaac     4860

aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgaaattgta aacgttaata     4920

ttttgttaaa attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg     4980

aaatcggcaa aatcccttat aaatcaaaag aatagaccga gatagggttg agtgttgttc     5040

cagtttggaa caagagtcca ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa     5100

ccgtctatca gggcgatggc ccactacgtg aaccatcacc ctaatcaagt tttttggggt     5160

cgaggtgccg taaagcacta aatcggaacc ctaaagggag cccccgattt agagcttgac     5220

ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa agcgaaagga gcgggcgcta     5280

gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac cacacccgcc gcgcttaatg     5340

cgccgctaca gggcgcgtcc cattcgcca                                       5369


<210>  95
<211>  2187
<212>  DNA
<213>  Psilocybe cubensis

<400>  95
atggcttcta gttcttccga tgtcttcgtt ttgggtctag gtgttgtttt ggctgccttg       60

tatatcttca gagaccaatt attcgctgct tctaagccaa aggtggctcc agtttccact      120

acgaagcctg ccaacggttc cgctaaccca agagacttca tcgccaagat gaaacaaggt      180

aagaagagaa tcgtaatctt ctacggttct caaactggta ccgctgaaga atatgctatt      240

cgtttggcta aggaagctaa gcaaaagttc ggtctagcct ccttggtttg tgatccagaa      300

gaatacgatt ttgaaaagtt ggaccaattg ccagaagatt ctattgcttt cttcgtcgtt      360

gctacctatg gtgaaggtga acctacagac aacgctgtcc aattgttgca aaacttgcaa      420

gatgaaagct tcgaattctc ctctggtgag agaaagttgt caggtttgaa gtacgttgtt      480

tttggtctgg gtaacaagac ctacgaacat tacaacctca ttgggagaac tgttgacgct      540

caattggcca agatgggtgc tatcagaatc ggtgaaagag gtgaaggtga tgatgacaag      600

tccatggaag aagactactt ggaatggaag gatggtatgt gggaagcgtt tgccactgct      660

atgggtgttg aagaaggtca aggtggtgac tccgctgatt tcgtcgtttc cgaattggaa      720

tctcacccac cagaaaaggt ttaccaaggt gaattttctg ctagagcttt aaccaaaacc      780

aagggtattc acgacgctaa gaatcctttt gctgctccaa ttgcggttgc tagagaattg      840

ttccaatctg ttgtcgatag aaactgtgtc cacgtcgaat tcaacattga aggctctggt      900

atcacctatc aacacggtga ccacgttggt ttgtggccat tgaatccaga tgttgaagtc      960

gaacggttgt tgtgtgtttt aggtttagct gaaaagagag atgctgtcat ctccattgaa     1020

tccttagacc cggctttggc taaggttcca ttcccagtcc caactactta cggtgctgtg     1080

ttgagacact acattgacat ctctgctgtc gccggtagac aaatcttggg tactttgtcc     1140

aaattcgctc caaccccaga agctgaagct ttcttgagaa acttgaacac taacaaggaa     1200

gaataccaca acgtcgtcgc taacggttgt ttgaaattgg gtgaaatttt gcaaatcgct     1260

accggtaacg acattactgt cccaccaact actgccaaca ccaccaaatg gccaattcca     1320

ttcgacatca ttgtttctgc catcccaaga ttgcaaccaa gatactactc tatctcttct     1380

tccccaaaaa ttcatccaaa caccatccac gctaccgttg ttgtgctcaa atacgaaaac     1440

gttccaaccg aaccaatccc aagaaagtgg gtttacggtg tcggtagtaa cttcttgttg     1500

aatttaaagt acgctgttaa caaggaacca gttccataca tcactcaaaa tggcgaacaa     1560

agagtcggtg tcccggaata cttgattgct ggtccacgtg gttcttacaa gactgaatct     1620

ttctacaagg ctccaatcca tgttagacgt tctactttcc gtttgccaac caacccaaag     1680

tctccagtca tcatgattgg tccaggtact ggtgtcgccc cattcagagg cttcgttcaa     1740

gaaagagttg ccttggccag aagatccatc gaaaagaacg gtcctgactc tttggctgac     1800

tggggtcgta tttccttgtt ctacggttgt agaagatccg acgaagactt cttgtacaag     1860

gacgaatggc cacaatacga agctgagttg aagggtaagt tcaagttgca ctgtgctttc     1920

tccagacaaa actacaagcc agacggttct aagatttacg tccaagattt gatctgggaa     1980

gacagagaac acattgccga tgccatctta aacggtaagg gttacgtcta catctgcggt     2040

gaagctaagt ccatgtctaa acaagttgaa gaagttctag ccaagatctt gggcgaagcc     2100

aaaggtggtt ccggtccagt tgaaggtgtt gctgaagtca agttactgaa ggaacggtcc     2160

agattgatgt tggatgtctg gtcttga                                         2187


<210>  96
<211>  728
<212>  PRT
<213>  Psilocybe cubensis

<400>  96

Met Ala Ser Ser Ser Ser Asp Val Phe Val Leu Gly Leu Gly Val Val 
1               5                   10                  15      


Leu Ala Ala Leu Tyr Ile Phe Arg Asp Gln Leu Phe Ala Ala Ser Lys 
            20                  25                  30          


Pro Lys Val Ala Pro Val Ser Thr Thr Lys Pro Ala Asn Gly Ser Ala 
        35                  40                  45              


Asn Pro Arg Asp Phe Ile Ala Lys Met Lys Gln Gly Lys Lys Arg Ile 
    50                  55                  60                  


Val Ile Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu Tyr Ala Ile 
65                  70                  75                  80  


Arg Leu Ala Lys Glu Ala Lys Gln Lys Phe Gly Leu Ala Ser Leu Val 
                85                  90                  95      


Cys Asp Pro Glu Glu Tyr Asp Phe Glu Lys Leu Asp Gln Leu Pro Glu 
            100                 105                 110         


Asp Ser Ile Ala Phe Phe Val Val Ala Thr Tyr Gly Glu Gly Glu Pro 
        115                 120                 125             


Thr Asp Asn Ala Val Gln Leu Leu Gln Asn Leu Gln Asp Glu Ser Phe 
    130                 135                 140                 


Glu Phe Ser Ser Gly Glu Arg Lys Leu Ser Gly Leu Lys Tyr Val Val 
145                 150                 155                 160 


Phe Gly Leu Gly Asn Lys Thr Tyr Glu His Tyr Asn Leu Ile Gly Arg 
                165                 170                 175     


Thr Val Asp Ala Gln Leu Ala Lys Met Gly Ala Ile Arg Ile Gly Glu 
            180                 185                 190         


Arg Gly Glu Gly Asp Asp Asp Lys Ser Met Glu Glu Asp Tyr Leu Glu 
        195                 200                 205             


Trp Lys Asp Gly Met Trp Glu Ala Phe Ala Thr Ala Met Gly Val Glu 
    210                 215                 220                 


Glu Gly Gln Gly Gly Asp Ser Ala Asp Phe Val Val Ser Glu Leu Glu 
225                 230                 235                 240 


Ser His Pro Pro Glu Lys Val Tyr Gln Gly Glu Phe Ser Ala Arg Ala 
                245                 250                 255     


Leu Thr Lys Thr Lys Gly Ile His Asp Ala Lys Asn Pro Phe Ala Ala 
            260                 265                 270         


Pro Ile Ala Val Ala Arg Glu Leu Phe Gln Ser Val Val Asp Arg Asn 
        275                 280                 285             


Cys Val His Val Glu Phe Asn Ile Glu Gly Ser Gly Ile Thr Tyr Gln 
    290                 295                 300                 


His Gly Asp His Val Gly Leu Trp Pro Leu Asn Pro Asp Val Glu Val 
305                 310                 315                 320 


Glu Arg Leu Leu Cys Val Leu Gly Leu Ala Glu Lys Arg Asp Ala Val 
                325                 330                 335     


Ile Ser Ile Glu Ser Leu Asp Pro Ala Leu Ala Lys Val Pro Phe Pro 
            340                 345                 350         


Val Pro Thr Thr Tyr Gly Ala Val Leu Arg His Tyr Ile Asp Ile Ser 
        355                 360                 365             


Ala Val Ala Gly Arg Gln Ile Leu Gly Thr Leu Ser Lys Phe Ala Pro 
    370                 375                 380                 


Thr Pro Glu Ala Glu Ala Phe Leu Arg Asn Leu Asn Thr Asn Lys Glu 
385                 390                 395                 400 


Glu Tyr His Asn Val Val Ala Asn Gly Cys Leu Lys Leu Gly Glu Ile 
                405                 410                 415     


Leu Gln Ile Ala Thr Gly Asn Asp Ile Thr Val Pro Pro Thr Thr Ala 
            420                 425                 430         


Asn Thr Thr Lys Trp Pro Ile Pro Phe Asp Ile Ile Val Ser Ala Ile 
        435                 440                 445             


Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Lys Ile 
    450                 455                 460                 


His Pro Asn Thr Ile His Ala Thr Val Val Val Leu Lys Tyr Glu Asn 
465                 470                 475                 480 


Val Pro Thr Glu Pro Ile Pro Arg Lys Trp Val Tyr Gly Val Gly Ser 
                485                 490                 495     


Asn Phe Leu Leu Asn Leu Lys Tyr Ala Val Asn Lys Glu Pro Val Pro 
            500                 505                 510         


Tyr Ile Thr Gln Asn Gly Glu Gln Arg Val Gly Val Pro Glu Tyr Leu 
        515                 520                 525             


Ile Ala Gly Pro Arg Gly Ser Tyr Lys Thr Glu Ser Phe Tyr Lys Ala 
    530                 535                 540                 


Pro Ile His Val Arg Arg Ser Thr Phe Arg Leu Pro Thr Asn Pro Lys 
545                 550                 555                 560 


Ser Pro Val Ile Met Ile Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
                565                 570                 575     


Gly Phe Val Gln Glu Arg Val Ala Leu Ala Arg Arg Ser Ile Glu Lys 
            580                 585                 590         


Asn Gly Pro Asp Ser Leu Ala Asp Trp Gly Arg Ile Ser Leu Phe Tyr 
        595                 600                 605             


Gly Cys Arg Arg Ser Asp Glu Asp Phe Leu Tyr Lys Asp Glu Trp Pro 
    610                 615                 620                 


Gln Tyr Glu Ala Glu Leu Lys Gly Lys Phe Lys Leu His Cys Ala Phe 
625                 630                 635                 640 


Ser Arg Gln Asn Tyr Lys Pro Asp Gly Ser Lys Ile Tyr Val Gln Asp 
                645                 650                 655     


Leu Ile Trp Glu Asp Arg Glu His Ile Ala Asp Ala Ile Leu Asn Gly 
            660                 665                 670         


Lys Gly Tyr Val Tyr Ile Cys Gly Glu Ala Lys Ser Met Ser Lys Gln 
        675                 680                 685             


Val Glu Glu Val Leu Ala Lys Ile Leu Gly Glu Ala Lys Gly Gly Ser 
    690                 695                 700                 


Gly Pro Val Glu Gly Val Ala Glu Val Lys Leu Leu Lys Glu Arg Ser 
705                 710                 715                 720 


Arg Leu Met Leu Asp Val Trp Ser 
                725             


<210>  97
<211>  5203
<212>  DNA
<213>  Artificial Sequenec

<220>
<223>  pETM6-H10 vector

<400>  97
gaagaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag       60

gagatataca tatggcagat ctcaattgga tatcggccgg ccacgcgatc gctgacgtcg      120

gtaccctcga gtctggtaaa gaaaccgctg ctgcgaaatt tgaacgccag cacatggact      180

cgtctactag tcgcagctta attaacctaa actgctgcca ccgctgagca ataactagca      240

taaccccttg gggcctctaa acgggtcttg aggggttttt tgctagcgaa aggaggagtc      300

gactatatcc ggattggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt      360

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc      420

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg      480

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat      540

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg      600

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct      660

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa      720

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt      780

tctggcggca cgatggcatg agattatcaa aaaggatctt cacctagatc cttttaaatt      840

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc      900

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg      960

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     1020

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     1080

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     1140

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     1200

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     1260

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     1320

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     1380

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     1440

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     1500

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     1560

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     1620

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     1680

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     1740

aatgttgaat actcatactc ttcctttttc aatcatgatt gaagcattta tcagggttat     1800

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggtcatgac     1860

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1920

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1980

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     2040

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     2100

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     2160

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     2220

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     2280

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2340

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2400

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2460

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2520

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2580

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2640

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2700

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2760

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2820

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2880

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2940

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     3000

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     3060

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     3120

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     3180

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     3240

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3300

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3360

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3420

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3480

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3540

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgctag     3600

tcatgccccg cgcccaccgg aaggagctga ctgggttgaa ggctctcaag ggcatcggtc     3660

gagatcccgg tgcctaatga gtgagctaac ttacattaat tgcgttgcgc tcactgcccg     3720

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     3780

gaggcggttt gcgtattggg cgccagggtg gtttttcttt tcaccagtga gacgggcaac     3840

agctgattgc ccttcaccgc ctggccctga gagagttgca gcaagcggtc cacgctggtt     3900

tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg gcgggatata acatgagctg     3960

tcttcggtat cgtcgtatcc cactaccgag atgtccgcac caacgcgcag cccggactcg     4020

gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg caaccagcat cgcagtggga     4080

acgatgccct cattcagcat ttgcatggtt tgttgaaaac cggacatggc actccagtcg     4140

ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga gatatttatg ccagccagcc     4200

agacgcagac gcgccgagac agaacttaat gggcccgcta acagcgcgat ttgctggtga     4260

cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt cttcatggga gaaaataata     4320

ctgttgatgg gtgtctggtc agagacatca agaaataacg ccggaacatt agtgcaggca     4380

gcttccacag caatggcatc ctggtcatcc agcggatagt taatgatcag cccactgacg     4440

cgttgcgcga gaagattgtg caccgccgct ttacaggctt cgacgccgct tcgttctacc     4500

atcgacacca ccacgctggc acccagttga tcggcgcgag atttaatcgc cgcgacaatt     4560

tgcgacggcg cgtgcagggc cagactggag gtggcaacgc caatcagcaa cgactgtttg     4620

cccgccagtt gttgtgccac gcggttggga atgtaattca gctccgccat cgccgcttcc     4680

actttttccc gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg ggaaacggtc     4740

tgataagaga caccggcata ctctgcgaca tcgtataacg ttactggttt cacattcacc     4800

accctgaatt gactctcttc cgggcgctat catgccatac cgcgaaaggt tttgcgccat     4860

tcgatggtgt ccgggatctc gacgctctcc cttatgcgac tcctgcatta ggaagcagcc     4920

cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg aatggtgcat gcaaggagat     4980

ggcgcccaac agtcccccgg ccacggggcc tgccaccata cccacgccga aacaagcgct     5040

catgagcccg aagtggcgag cccgatcttc cccatcggtg atgtcggcga tataggcgcc     5100

agcaaccgca cctgtggcgc cggtgatgcc ggccacgatg cgtccggcgt agcctaggat     5160

cgagatcgat ctcgatcccg cgaaattaat acgactcact acg                       5203


<210>  98
<211>  3777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pRSM3 vector

<400>  98
cgctaacagc gcgatttgct ggtgacccaa tgcgaccaga tgctccacgc ccagtcgcgt       60

accgtcttca tgggagaaaa taatactgtt gatgggtgtc tggtcagaga catcaagaaa      120

taacgccgga acattagtgc aggcagcttc cacagcaatg gcatcctggt catccagcgg      180

atagttaatg atcagcccac tgacgcgttg cgcgagaaga ttgtgcaccg ccgctttaca      240

ggcttcgacg ccgcttcgtt ctaccatcga caccaccacg ctggcaccca gttgatcggc      300

gcgagattta atcgccgcga caatttgcga cggcgcgtgc agggccagac tggaggtggc      360

aacgccaatc agcaacgact gtttgcccgc cagttgttgt gccacgcggt tgggaatgta      420

attcagctcc gccatcgccg cttccacttt ttcccgcgtt ttcgcagaaa cgtggctggc      480

ctggttcacc acgcgggaaa cggtctgata agagacaccg gcatactctg cgacatcgta      540

taacgttact ggtttcacat tcaccaccct gaattgactc tcttccgggc gctatcatgc      600

cataccgcga aaggttttgc gccattcgat ggtgtccggg atctcgacgc tctcccttat      660

gcgactcctg cattaggaag cagcccagta gtaggttgag gccgttgagc accgccgccg      720

caaggaatgg tgcatgcaag gagatggcgc ccaacagtcc cccggccacg gggcctgcca      780

ccatacccac gccgaaacaa gcgctcatga gcccgaagtg gcgagcccga tcttccccat      840

cggtgatgtc ggcgatatag gcgccagcaa ccgcacctgt ggcgccggtg atgccggcca      900

cgatgcgtcc ggcgtagcct aggatcgaga tcgatctcga tcccgcgaaa ttaatacgac      960

tcactatagg ggaattgtga gcggataaca attcccctct agaaataatt ttgtttaact     1020

ttaagaagga gatatacata tggcagatct caattggata tcggccggcc acgcgatcgc     1080

tgacgtcggt accctcgagt ctggtaaaga aaccgctgct gcgaaatttg aacgccagca     1140

catggactcg tctactagtc gcagcttaat taacctaaac tgctgccacc gctgagcaat     1200

aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctagcgaaag     1260

gaggagtcga caagctgacg accgggtctc cgcaagtggc acttttcggg gaaatgtgcg     1320

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgaatta     1380

attcttagaa aaactcatcg agcatcaaat gaaactgcaa tttattcata tcaggattat     1440

caataccata tttttgaaaa agccgtttct gtaatgaagg agaaaactca ccgaggcagt     1500

tccataggat ggcaagatcc tggtatcggt ctgcgattcc gactcgtcca acatcaatac     1560

aacctattaa tttcccctcg tcaaaaataa ggttatcaag tgagaaatca ccatgagtga     1620

cgactgaatc cggtgagaat ggcaaaagtt tatgcatttc tttccagact tgttcaacag     1680

gccagccatt acgctcgtca tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg     1740

attgcgcctg agcgagacga aatacgcggt cgctgttaaa aggacaatta caaacaggaa     1800

tcgaatgcaa ccggcgcagg aacactgcca gcgcatcaac aatattttca cctgaatcag     1860

gatattcttc taatacctgg aatgctgttt tcccggggat cgcagtggtg agtaaccatg     1920

catcatcagg agtacggata aaatgcttga tggtcggaag aggcataaat tccgtcagcc     1980

agtttagtct gaccatctca tctgtaacat cattggcaac gctacctttg ccatgtttca     2040

gaaacaactc tggcgcatcg ggcttcccat acaatcgata gattgtcgca cctgattgcc     2100

cgacattatc gcgagcccat ttatacccat ataaatcagc atccatgttg gaatttaatc     2160

gcggcctaga gcaagacgtt tcccgttgaa tatggctcat actcttcctt tttcaatatt     2220

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga     2280

aaaataaaca aataggcatg cagcgctctt ccgcttcctc gctcactgac tcgctacgct     2340

cggtcgttcg actgcggcga gcggtgtcag ctcactcaaa agcggtaata cggttatcca     2400

cagaatcagg ggataaagcc ggaaagaaca tgtgagcaaa aagcaaagca ccggaagaag     2460

ccaacgccgc aggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     2520

cgctcaagcc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     2580

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     2640

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgttggta tctcagttcg     2700

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     2760

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     2820

ctggcagcag ccattggtaa ctgatttaga ggactttgtc ttgaagttat gcacctgtta     2880

aggctaaact gaaagaacag attttggtga gtgcggtcct ccaacccact taccttggtt     2940

caaagagttg gtagctcagc gaaccttgag aaaaccaccg ttggtagcgg tggtttttct     3000

ttatttatga gatgatgaat caatcggtct atcaagtcaa cgaacagcta ttccgttact     3060

ctagatttca gtgcaattta tctcttcaaa tgtagcacct gaagtcagcc ccatacgata     3120

taagttgtaa ttctcatgtt agtcatgccc cgcgcccacc ggaaggagct gactgggttg     3180

aaggctctca agggcatcgg tcgagatccc ggtgcctaat gagtgagcta acttacatta     3240

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     3300

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgccaggg tggtttttct     3360

tttcaccagt gagacgggca acagctgatt gcccttcacc gcctggccct gagagagttg     3420

cagcaagcgg tccacgctgg tttgccccag caggcgaaaa tcctgtttga tggtggttaa     3480

cggcgggata taacatgagc tgtcttcggt atcgtcgtat cccactaccg agatgtccgc     3540

accaacgcgc agcccggact cggtaatggc gcgcattgcg cccagcgcca tctgatcgtt     3600

ggcaaccagc atcgcagtgg gaacgatgcc ctcattcagc atttgcatgg tttgttgaaa     3660

accggacatg gcactccagt cgccttcccg ttccgctatc ggctgaattt gattgcgagt     3720

gagatattta tgccagccag ccagacgcag acgcgccgag acagaactta atgggcc        3777


