б 

<110>  ϾƼ޹˾
 
<120>  NKǶϿԭ

<130>  BHCN25

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1

<400>  1
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
                5                   10                  15

Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
            20                  25                  30

Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45

Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65                  70                  75                  80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu
        115                 120                 125

Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys
    130                 135                 140
 
Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg
145                 150                 155                 160

Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser
                165                 170                 175

Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile
            180                 185                 190

Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln
        195                 200                 205

Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly
    210                 215                 220

Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
225                 230                 235                 240

Ser Ser


<210>  2
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1

<400>  2
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc    60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg    300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc    360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg    420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc    480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac    540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt    600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat    660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc    720

tcctca                                                               726


<210>  3
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8Ĥṹ

<400>  3
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                5                   10                  15

Ser Leu Val Ile Thr Leu Tyr Cys Lys
            20                  25


<210>  4
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8Ĥṹ

<400>  4
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60

accctttact gcaaa                                                      75


<210>  5
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28Ĥṹ

<400>  5
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                5                   10                  15

Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25


<210>  6
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28Ĥṹ

<400>  6
ttttgggtcc tcgtcgtagt tggaggggta cttgcctgtt atagcctcct ggttaccgta     60

gcatttatta tattctgggt g                                               81


<210>  7
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28̼ṹ

<400>  7
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                5                   10                  15

Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30

Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40


<210>  8
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28̼ṹ

<400>  8
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120

tcc                                                                  123


<210>  9
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB̼ṹ

<400>  9
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                5                   10                  15

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
            20                  25                  30

Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40


<210>  10
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB̼ṹ

<400>  10
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     120


<210>  11
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3źŴṹ

<400>  11
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                5                   10                  15

Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80

Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95

Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110

Arg


<210>  12
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3źŴṹ

<400>  12
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    300

acctacgacg cccttcacat gcaggccctg ccccctcgc                           339


<210>  13
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3źŴṹ

<400>  13
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
                5                   10                  15

Gly Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Phe Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
    50                  55                  60

Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
65                  70                  75                  80

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser
                85                  90                  95

Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro
            100                 105                 110
Pro Arg


<210>  14
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3źŴṹ

<400>  14
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctttaacg agctcaatct aggacgaaga gaggagttcg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg    180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc    240

gagcgccgga ggggcaaggg gcacgatggc cttttccagg gtctcagtac agccaccaag    300

gacacctttg acgcccttca catgcaggcc ctgccccctc gc                       342


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  B2Mź

<400>  15
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
                5                   10                  15

Gly Leu Glu Ala
            20


<210>  16
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  B2Mź

<400>  16
atgtcccgct ctgttgcttt ggctgtgctg gcccttttgt cccttagcgg actggaggcc     60


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8ź

<400>  17
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
                5                   10                  15

His Ala Ala Arg Pro
            20


<210>  18
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8ź

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccg                                                                   63


<210>  19
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8

<400>  19
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                5                   10                  15

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45


<210>  20
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8

<400>  20
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120

gacttcgcct gtgat                                                     135


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28

<400>  21
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
                5                   10                  15

Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30

Phe Pro Gly Pro Ser Lys Pro
        35


<210>  22
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28

<400>  22
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc       117


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4

<400>  23
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                5                   10


<210>  24
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4

<400>  24
gaaagcaaat acgggccgcc gtgtccaccc tgtccg                               36


<210>  25
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2

<400>  25
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly 
                5                   10                  15

Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly
            20                  25                  30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45

Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr
65                  70                  75                  80

Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln
        115                 120                 125

Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys
    130                 135                 140

Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val Lys
145                 150                 155                 160

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu
                165                 170                 175

Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr Leu
            180                 185                 190

Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser Leu
        195                 200                 205

Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr Tyr
    210                 215                 220

Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser
225                 230                 235


<210>  26
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2

<400>  26
gacatccaga tgacccagag ccctgccagc ctgtctacca gcctgggcga gacagtgacc     60

atccagtgtc aggccagcga ggacatctac tctggcctgg cttggtatca gcagaagccc    120 

ggcaagagcc ctcagctgct gatctacggc gccagcgacc tgcaggacgg cgtgcctagc    180

agattcagcg gcagcggctc cggaacccag tacagcctga agatcaccag catgcagacc    240

gaggacgagg gcgtgtactt ctgccagcaa ggcctgacct accctagaac cttcggagga    300 

ggcaccaagc tggaactgaa gggcggaggc ggaagtggag gcggaggatc tggcggcgga    360

ggctctgaag tgcagctgca gcagtctggc gctgaactgg tccggcctgg cactagcgtg    420

aagctgtcct gcaaggtgtc cggcgacacc atcaccttct actacatgca cttcgtgaag    480

cagaggccag gacagggcct ggaatggatc ggcagaatcg accctgagga cgagagcacc    540

aagtacagcg agaagttcaa gaacaaggcc accctgaccg ccgacaccag cagcaacacc    600

gcctacctga agctgtctag cctgacctcc gaggacaccg ccacctactt ttgcatctac    660

ggcggctact acttcgacta ctggggccag ggcgtgatgg tcaccgtgtc cagc          714


<210>  27
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-1

<400>  27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30

Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45

Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Lys Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr Trp Gly
            100                 105                 110

Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125

Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala
    130                 135                 140

Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser Gly
145                 150                 155                 160

Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu
                165                 170                 175

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Asp Asp Leu Leu Pro
            180                 185                 190

Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala
        195                 200                 205

Phe Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr
    210                 215                 220

Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val Phe Gly Gly Gly
225                 230                 235                 240

Thr Lys Leu Thr Val Leu
                245


<210>  28
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-1

<400>  28
caggtccagt tggttgaaag tggaggaggg ttggtgaaac ccggaggatc cttgcgactg     60

tcttgcgcag ctagtggctt cacgttcagt tcctatggca tgcattgggt gagacaagct    120

cctggtaaag gcttggaatg ggtggccttc ataaggtatg acggttcaaa taaatattac    180

gccgactccg tcaagggtcg atttaccatt tccagggaca attcaaaaaa tacattgtac    240

ttgcagatga atagccttag agcggaggac acggccgtct actactgcgc gaaggatcga    300

gggttgggcg acggcactta ctttgactac tggggacagg gaacgacggt cacagtctcc    360

tcaggcggtg gtgggagcgg tggtggagga agtggaggtg gtggttcaca gtccgcactc    420

actcagccag cgtccgttag tggttcccct ggccagagta tcaccattag ttgcagtggc    480

agttcctcaa atattgggaa taacgcagtg aattggtatc agcaattgcc tggcaaagcg    540

cccaaattgc ttatttatta cgacgatctc cttccctctg gagtttccga tcggttctca    600

ggctctaaga gcggtacctc tgcgtttctc gccatatctg gtcttcaatc agaagatgaa    660

gccgactatt actgcgctgc atgggatgac agccttaatg gtccggtttt tgggggcgga    720

accaaactta cagtcctg                                                  738


<210>  29
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-2

<400>  29
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
                5                   10                  15

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
                85                  90                  95

Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Gly Gly Gly
            100                 105                 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser
        115                 120                 125

Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
    130                 135                 140

Ala Ser Gly Phe Thr Phe Asp Asp Tyr Gly Met Thr Trp Val Arg Gln
145                 150                 155                 160

Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Trp Asn Gly
                165                 170                 175

Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
            180                 185                 190

Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg
        195                 200                 205

Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Arg Glu Leu Tyr
    210                 215                 220

Tyr Tyr Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr
225                 230                 235                 240
                   
Val Ser Ser


<210>  30
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-2

<400>  30
gaaatcgttc ttacacaaag ccctggtact ttgtctctgt cccctggaga gcgagcgact     60

ctgagctgta gagcatccca atctgttagt agcagttacc tggcttggta ccaacagaaa    120

ccaggccagg cgccgcgctt gctcatttac ggtgctagta gtagagcaac aggaatcccc    180

gaccgcttta gtgggtcagg aagtggtact gactttacgc tgacgatcag cagactggaa    240

ccagaggatt tcgccgttta ttactgccaa cagtatggca gttcaccctt caccttcgga    300

cctggtacaa aagtggacat taaacgaggt gggggaagcg gaggagggtc aggaggtggt    360

tcagaggttc agctcgtgga gagtgggggt ggcgtagtac gaccaggtgg ttccctccga    420

ctgagctgcg ccgctagtgg ttttactttc gacgattacg gaatgacctg ggtcaggcaa    480

gcaccaggca agggtttgga gtgggtttct gggattaact ggaatggggg ttctacggga    540

tacgcagact ctgttaaggg gcggtttaca atatcacgag ataacgctaa aaactccttg    600

tatttgcaga tgaacagttt gcgggctgaa gacactgctc tttactactg cgcacgggaa    660

cgagaattgt actattatta ttacgggctc gatgtttggg gccaagggac aacagtgact    720

gtttccagc                                                            729


<210>  31
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-3

<400>  31
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
                5                   10                  15
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45

Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80

Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
                85                  90                  95

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly
            100                 105                 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val His Leu Gln Glu Ser
        115                 120                 125

Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr
    130                 135                 140

Val Ser Asp Asp Ser Ile Ser Ser Tyr Tyr Trp Ser Trp Ile Arg Gln
145                 150                 155                 160

Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile Ser Tyr Ser Gly
                165                 170                 175

Ser Ala Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val
            180                 185                 190

Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
        195                 200                 205

Ala Asp Thr Ala Val Tyr Tyr Cys Ala Asn Trp Asp Asp Ala Phe Asn
    210                 215                 220

Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
225                 230                 235


<210>  32
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-3

<400>  32
gaaattgtgc ttacccagtc ccctggcaca ctcagcctca gtccagggga acgcgcgacg     60

ctgtcatgta gggcctcaca atctgtgagt tccagctatc tggcgtggta tcagcaaaag    120

ccgggtcaag cccctcgctt gcttatttac ggagcaagca gtagagccac tggtattcct    180

gatcgcttca gcggcagcgg aagcggcacc gacttcacgt tgaccattag ccggcttgaa    240

ccggaagatt ttgcagttta ctattgccaa caatatgggt cctctccctg gactttcgga    300

caggggacga aggtggaaat aaagcgaggg ggcggcagtg gcggaggcag tggaggagga    360

agccaagtac acctgcagga atctggcccg ggtctcgtca aaccttccga aacattgagt    420

cttacttgta cagtttcaga tgatagcatt tccagctact attggtcttg gattaggcaa    480

ccccccggaa aaggtttgga atggattggt cacattagtt attcagggtc agctaattat    540

aatccttctt tgaaatcaag ggtaacaata tcagtggaca cgagtaaaaa ccagtttagt    600

cttaaactta gcagcgtaac agcagcggat actgccgtat attactgtgc aaattgggac    660

gacgccttta atatctgggg acaggggacg atggttacgg tatctagc                 708


<210>  33
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-4

<400>  33
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
                5                   10                  15

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr
            20                  25                  30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45

Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Trp
                85                  90                  95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly
        115                 120                 125

Ala Glu Val Lys Glu Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Asn
    130                 135                 140

Ser Gly Tyr Ser Phe Thr Asn Tyr Trp Val Gly Trp Val Arg Gln Met
145                 150                 155                 160

Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser
                165                 170                 175

Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala
            180                 185                 190

Asp Lys Ser Ile Asn Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala
        195                 200                 205

Ser Asp Thr Ala Met Tyr Tyr Cys Gly Arg Leu Thr Met Phe Arg Gly 
    210                 215                 220

Ile Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
225                 230                 235                 240

Val Ser Ser


<210>  34
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKGD scFv-4

<400>  34
gaaatagtcc ttacgcaatc cccagctaca ttgagcttga gtccaggaga gcgagcgacc     60

ctcagttgta gagctagtca gtcagtaagc tcctatctcg cttggtatca gcaaaagcca    120

ggacaagccc ccagactcct catttacgac gccagtaaca gggcaactgg tatccctgcg    180

cgctttagtg gcagcggttc aggcacagat ttcactttga ccatatcatc attggagccc    240

gaagatttcg cagtgtacta ctgccaacaa cgctcaaact ggccctggac tttcggtcag    300

gggaccaagg ttgaaatcaa gaggggaggc ggttccggcg gaggatcagg aggaggctca    360

gaagttcagt tggtgcaatc tggagcggag gtaaaagaac cgggggaatc attgaaaata    420

agctgtaaaa atagtggata tagtttcaca aactactggg tcgggtgggt tcgccagatg    480

ccgggtaagg gactggagtg gatggggata atctatccag gcgactcaga cactcgctat    540

agtccttctt ttcaagggca agtcacaata agtgccgaca agagtattaa caccgcatat    600

cttcagtggt cctccttgaa agcgagtgat acggcgatgt attactgcgg acgacttact    660

atgttccgag gtataatcat tggatacttc gactattggg gccaagggac cctggtgacg    720

gtttcaagc                                                            729


<210>  35
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1

<400>  35
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
                5                   10                  15

Glu Thr Val Thr Ile Thr Cys Arg Val Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30

Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45

Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80

Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Glu
        115                 120                 125

Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys
    130                 135                 140

Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile
145                 150                 155                 160

Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr
                165                 170                 175

Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Glu Ser Arg Ile Ser Ile
            180                 185                 190

Thr Arg Asp Thr Ser Thr Asn Gln Phe Phe Leu Gln Leu Asn Ser Val
        195                 200                 205

Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Gly Tyr Tyr
    210                 215                 220

Gly Ser Ser Trp Gly Val Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240

Thr Val Ser Ala


<210>  36
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1

<400>  36
gatattcaga tgacacagtc tcctgcctct ctgtctgcaa gcgttggtga aacggtcact     60

ataacatgtc gggtgagtga aaatatctat tcatatctcg cctggtacca gcagaaacaa    120

ggcaagagtc cccaattgct tgtttacaat gccaaaacgc tggctgaagg tgttccatct    180

cggtttagcg gatcaggaag cggaacgcag ttttccctta agatcaattc ccttcaacct    240

gaggactttg gatcttatta ttgccaacat cattatggga caccttggac gtttggagga    300

gggacaaaac tggagataaa aggaggtggt ggcagtggtg gaggaggaag tgggggtggg    360

ggatcagaag tacagctgca agagagcggg ccgggtctcg ttaaaccatc ccaatccctt    420

agcctcactt gtactgttac gggatacagc ataacctcag attatgcctg gaactggatc    480

agacagttcc ccggcaacaa actcgaatgg atgggctaca taacttacag tggtagcact    540

tcctacaacc ccagtttgga gtcacgcatt agcatcacga gggatactag cactaatcag    600

ttctttcttc agctgaatag tgttaccacg gaggatacgg cgacgtatta ctgcgccagg    660

ggcggttatt atgggtcatc ctggggagta tttgcttact gggggcaagg aacccttgtc    720

actgtctcag cg                                                        732


<210>  37
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2

<400>  37
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
                5                   10                  15

Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30

Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45

Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro
65                  70                  75                  80

Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Leu
                85                  90                  95

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln
        115                 120                 125

Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys
    130                 135                 140

Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys
145                 150                 155                 160

1Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn
                 165                 170                 175

Ile Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu
            180                 185                 190

Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu
        195                 200                 205

Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Gly Gly Ser
    210                 215                 220

Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser
225                 230                 235


<210>  38
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2

<400>  38
gatattgtga tgactcaaag tcccgctact ctttctgtta caccgggaga tcgcgtatca     60

ctgagctgcc gcgcctcaca gtccatctct gattatcttc actggtatca acaaaagtca    120

catgagtctc caaggctttt gataaaatat gcgagccagt ccatctctgg cattcctagt    180

cgctttagcg ggagtggctc aggaagcgac ttcaccctca gcatcaattc agttgaacct    240

gaggacgtcg gggtttatta ttgccagaat gggcactcct tccccctgac atttggtgcc    300

ggcaccaaac ttgagcttaa aggcggagga ggttctggtg gtggtggatc cgggggcggc    360

ggatccgagg tgcagcttca acagagcggt cccgaattgg tcaagccggg agcttccgtt    420

aaaattagct gtaaaacctc tggatatact tttacggaat atactatgca ttgggttaag    480

cagtcacacg gaaagagtct tgaatggata ggcggtatct ctcccaatat cgggggcacc    540

tcttacaacc agaagttcaa gggtaaagct acgttgacgg tggacaagtc ttcttcaacc    600

gcttatatgg aattgagatc actcacttca gaagactctg cagtatatta ctgtgctcga    660

cggggtggtt cctttgatta ttggggtcag ggaactacgc tgactgttag tagc          714


<210>  39
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3

<400>  39
Asp Ile Gln Met Ile Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly
                5                   10                  15

Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn
            20                  25                  30

Leu Ala Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45

Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser
65                  70                  75                  80

Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Arg
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
        115                 120                 125

Ser Ala Val Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys
    130                 135                 140

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe Thr Met His Trp Val Lys
145                 150                 155                 160

Gln Arg Pro Gly Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser 
                165                 170                 175

Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys Asp Lys Thr Thr Leu Thr
            180                 185                 190

Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Asp Ser Leu Thr
        195                 200                 205

Ser Asp Asp Ser Ala Val Tyr Tyr Cys Val Arg Gly Ser Ser Arg Gly
    210                 215                 220

Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
225                 230                 235


<210>  40
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3

<400>  40
gatatacaaa tgatccagag ccctgcatca ctttcagttt ctgtggggga gactgtcaca     60

attacttgta gggcgagtga aaacatctat tcaaacctcg cgtggtttca acagaagcag    120

ggcaagtctc ctcaactgct cgtatatgcg gcaaccaatc tggcggacgg cgtcccctcc    180

aggttttccg gtagcggatc tggtactcag tactccttga agattaattc cctgcaaagt    240

gaagatttcg gaatctacta ttgccaacat ttttggggta cgccgagaac gtttggaggc    300

gggacaaagc tcgaaattaa aggaggggga ggcagtgggg gcggtggatc aggtggtggt    360

gggagccaag tgcaacttca gcaatctgcc gtagaacttg ctaggcccgg ggcgtcagtt    420

aaaatgtctt gtaaggcatc tgggtataca ttcacgtcat tcactatgca ctgggttaaa    480

caacgcccgg gaggattgga gtggataggg tatataaacc ccagtagtgg gtacactgag    540 

tacaatcaaa agtttaaaga taagactacg ttgactgccg ataaatcctc aagcacagcg    600

tatatgcaac tcgattctct tacttctgat gattccgcag tgtattactg tgtacgcggg    660

tcatcacgcg gttttgacta ttggggccaa ggaactcttg taactgtaag tgcg          714
 

<210>  41
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-4

<400>  41
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
                5                   10                  15

Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr
            20                  25                  30

Leu Ala Trp Cys Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45

Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60

Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80

Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His His Tyr Asp Thr Pro Leu
                85                  90                  95

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu
        115                 120                 125

Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys
    130                 135                 140

Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile
145                 150                 155                 160

Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr Tyr
                165                 170                 175

Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile
            180                 185                 190

Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val
        195                 200                 205

Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Cys Trp Asp Tyr
    210                 215                 220

Ala Leu Tyr Ala Met Asp Cys Trp Gly Gln Gly Thr Ser Val Thr Val
225                 230                 235                 240

Ser Ser


<210>  42
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-4

<400>  42
gatattcaaa tgacacagtc cccagccagt cttagcgcta gtgtgggtga gaccgtgact     60

ataacttgca gaacgtctga gaatatatat tcctatctgg cttggtgcca acaaaaacag    120

gggaagagtc cgcaactgct cgtctacaac gcgaaaaccc tcgccgaagg tgtccccagt    180

cgatttagtg gatctggcag tggcacccat ttcagcctca aaatcaactc actccagcca    240

gaggattttg ggatatatta ctgtcagcat cattacgata cgcctctgac ttttggggca    300

ggcacaaagc tcgaattgaa gggaggaggt ggatctggcg gaggtggcag tggcgggggt    360

gggagcgatg tccagcttca ggaatctggc ccgggccttg ttaagccatc acagagtctg    420

agcctgacat gcactgtgac cgggtattcc atcacaagcg attatgcctg gaattggata    480

cggcaatttc ccggcaacaa gttggagtgg atggggtaca tcacttattc agggtcaacg    540

aattataatc ccagtttgaa gtcccgcatc agtataacgc gagatacctc caagaaccag    600

ttttttctcc agcttaatag tgttacgaca gaggataccg ctacctatta ctgtgctcgg    660

tgttgggatt atgctttgta tgcaatggat tgctgggggc agggcacctc cgtcacagtg    720

tcaagc                                                               726


<210>  43
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5

<400>  43
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
                5                   10                  15

Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser
            20                  25                  30

Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile
        35                  40                  45

Tyr Ala Thr Ser Arg Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly
    50                  55                  60

Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser
65                  70                  75                  80

Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
        115                 120                 125

Pro Gly Ser Val Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys
    130                 135                 140

Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser Trp Met His Trp Ala Lys
145                 150                 155                 160

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly His Ile His Pro Asn
                165                 170                 175

Ser Gly Ile Ser Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu
            180                 185                 190

Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Val Asp Leu Ser Ser Leu
        195                 200                 205

Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ser Arg Gly Gly Arg Phe
    210                 215                 220

Asp Asp Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
225                 230                 235

<210>  44
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5

<400>  44
gatatacaga tgactcagag cccatcctca ttgagtgcat ccctgggaga gagggtatca     60

ctgacttgtc gcgcctcaca agatattggg tcttcactta attggctcca acaggagcca    120

gatggtacaa tcaaaaggct tatttatgct acatcacgct tggatagcgg cgttcctaaa    180 

cgcttcagcg gtagccgaag tggtagcgat tatagtctga ccatcagcag cctcgaatca    240

gaagacttcg tggactatta ctgccttcaa tacgcttcat ccccctggac gtttggcggt    300

ggaaccaagc ttgaaattaa aggagggggt ggttcaggtg gtggcggaag tggtggggga    360

ggttcacaag tccaactcca gcaacccggg agcgttctcg taaggccggg tgcttctgtt    420

aagttgtcat gcaaagcttc tggttacact ttcaccagtt catggatgca ctgggccaag    480

cagcgccctg gtcaaggact cgaatggatc ggacatattc atcccaacag cgggatttcc    540

aattacaatg agaagttcaa agggaaagca actcttaccg tggacactag ctcatcaact    600

gcctacgtgg atctgagttc actgacttca gaggattcag cggtttacta ctgctcacgg    600

ggtggtagat tcgatgattg gggagcaggg accacagtaa cggtgtccag c             711


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  DAP10

<400>  45
Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met
                5                   10                  15

Pro Gly Arg Gly
            20


<210>  46
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  DAP10

<400>  46
ccacgccgca gccccgccca agaagatggc aaagtctaca tcaacatgcc aggcaggggc     60


<210>  47
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  DAP12

<400>  47
Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
                5                   10                  15

Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly
            20                  25                  30

Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr
        35                  40                  45
Lys


<210>  48
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  DAP12

<400>  48
ggccgcctgg tgccgcgcgg ccgcggcgcg gcggaagcgg cgacccgcaa acagcgcatt     60

accgaaaccg aaagcccgta tcaggaactg cagggccagc gcagcgatgt gtatagcgat    120

ctgaacaccc agcgcccgta ttataaa                                        147


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-L1

<400>  49
Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn
                5                   10


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-L2

<400>  50
His Thr Ser Arg Leu His Ser
                5


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-L3

<400>  51
Gln Gln Gly Asn Thr Leu Pro Tyr Thr
                5


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-H1

<400>  52
Gly Val Ser Leu Pro Asp Tyr
                5


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-H2

<400>  53
Trp Gly Ser Glu Thr
                5


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-H3

<400>  54
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
                5                   10


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2 CDR-L1

<400>  55
Gln Ala Ser Glu Asp Ile Tyr Ser Gly Leu Ala
                5                   10


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2 CDR-L2

<400>  56
Gly Ala Ser Asp Leu Gln Asp
                5


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2 CDR-L3

<400>  57
Gln Gln Gly Leu Thr Tyr Pro Arg Thr
                5


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2 CDR-H1

<400>  58
Gly Asp Thr Ile Thr Phe Tyr
                5


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-2 CDR-H2

<400>  59
Asp Pro Glu Asp Glu Ser
                5


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD19 scFv-1 CDR-H3

<400>  60
Gly Gly Tyr Tyr Phe Asp Tyr
                5


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-1 CDR-L1

<400>  61
Gly Phe Thr Phe Ser Ser Tyr
                5


<210>  62
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-1 CDR-L2

<400>  62
Arg Tyr Asp Gly Ser Asn
                5


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-1 CDR-L3

<400>  63
Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr
                5                   10


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-1 CDR-H1

<400>  64
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn
                5                   10


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-1 CDR-H2

<400>  65
Tyr Asp Asp Leu Leu Pro Ser
                5


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-1 CDR-H3

<400>  66
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val
                5                   10


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-L1

<400>  67
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala
                5                   10


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-L2

<400>  68
Gly Ala Ser Ser Arg Ala Thr
                5


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-L3

<400>  69
Gln Gln Tyr Gly Ser Ser Pro Phe Thr
                5


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-H1

<400>  70
Gly Phe Thr Phe Asp Asp Tyr
                5
 

<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-H2

<400>  71
Asn Trp Asn Gly Gly Ser 
                5


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-H3

<400>  72
Glu Arg Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Leu Asp Val
                5                   10


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-3 CDR-L3

<400>  73
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
                5


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-3 CDR-H1

<400>  74
Asp Asp Ser Ile Ser Ser Tyr
                5


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-3 CDR-H2

<400>  75
Ser Tyr Ser Gly Ser
                5


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-2 CDR-H3

<400>  76
Trp Asp Asp Ala Phe Asn
                5


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-4 CDR-L1

<400>  77
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala
                5                   10


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-4 CDR-L2

<400>  78
Asp Ala Ser Asn Arg Ala Thr
                5


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-4 CDR-L3

<400>  79
Gln Gln Arg Ser Asn Trp Pro Trp Thr
            5


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-4 CDR-H1

<400>  80
Gly Tyr Ser Phe Thr Asn Tyr
                5


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-4 CDR-H2

<400>  81
Tyr Pro Gly Asp Ser Asp
                5


<210>  82
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2D scFv-4 CDR-H3

<400>  82
Leu Thr Met Phe Arg Gly Ile Ile Ile Gly Tyr Phe Asp Tyr
                5                   10


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1 CDR-L1

<400>  83
Arg Val Ser Glu Asn Ile Tyr Ser Tyr Leu Ala
                5                   10


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1 CDR-L2

<400>  84
Asn Ala Lys Thr Leu Ala Glu
                5


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1 CDR-L3

<400>  85
Gln His His Tyr Gly Thr Pro Trp Thr
                5


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1 CDR-H1

<400>  86
Gly Tyr Ser Ile Thr Ser Asp Tyr
                5


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1 CDR-H2

<400>  87
Thr Tyr Ser Gly Ser
                5


<210>  88
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-1 CDR-H3

<400>  88
Gly Gly Tyr Tyr Gly Ser Ser Trp Gly Val Phe Ala Tyr
                5                   10


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2 CDR-L1

<400>  89
Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His
                5                   10


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2 CDR-L2

<400>  90
Tyr Ala Ser Gln Ser Ile Ser
                5


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2 CDR-L3

<400>  91
Gln Asn Gly His Ser Phe Pro Leu Thr
                5


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2 CDR-H1

<400>  92
Gly Tyr Thr Phe Thr Glu Tyr
                5


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2 CDR-H2

<400>  93
Ser Pro Asn Ile Gly Gly 
                5


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-2 CDR-H3

<400>  94
Arg Gly Gly Ser Phe Asp Tyr
                5


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3 CDR-L1

<400>  95
Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala
                5                   10


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3 CDR-L2

<400>  96
Ala Ala Thr Asn Leu Ala Asp
                5


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3 CDR-L3

<400>  97
Gln His Phe Trp Gly Thr Pro Arg Thr
                5


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3 CDR-H1

<400>  98
Gly Tyr Thr Phe Thr Ser Phe
                5


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3 CDR-H2

<400>  99
Asn Pro Ser Ser Gly Tyr
                5


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-3 CDR-H3

<400>  100
Gly Ser Ser Arg Gly Phe Asp Tyr
                5


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-4 CDR-L1

<400>  101
Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
                5                   10


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-4 CDR-L3

<400>  102
Gln His His Tyr Asp Thr Pro Leu Thr 
                5


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-4 CDR-H1

<400>  103
Gly Tyr Ser Ile Thr Ser Asp Tyr
                5


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-4 CDR-H3

<400>  104
Cys Trp Asp Tyr Ala Leu Tyr Ala Met Asp Cys
                5                   10


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5 CDR-L1

<400>  105
Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn
                5                   10


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5 CDR-L2

<400>  106
Ala Thr Ser Arg Leu Asp Ser
                5


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5 CDR-L3

<400>  107
Gln His Phe Trp Gly Thr Pro Arg Thr
                5


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5 CDR-H1

<400>  108
Gly Tyr Thr Phe Thr Ser Ser
                5


<210>  109
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5 CDR-H2

<400>  109
His Pro Asn Ser Gly Ile
                5


<210>  110
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKp46 scFv-5 CDR-H3

<400>  110
Gly Gly Arg Phe Asp Asp
                5




















