                         SEQUENCE LISTING

<110>  De Staat der Nederlanden, vert. door de minister van VWS, 
       Ministerie van Volksgezondheid, Welzijn en Sport
       Intravacc B.V.
 
<120>  OmpA mutations enhance OMV production in Bordetella Pertussis

<130>  p6088044pct

<150>  EP 20194514.4
<151>  2020-09-04

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  193
<212>  PRT
<213>  Bordetella pertussis

<400>  1

Met Asn Lys Pro Ser Lys Phe Ala Leu Ala Leu Ala Phe Ala Ala Val 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ser Ala Gln Thr Val Asp Asn Trp Arg Asn 
            20                  25                  30          


Pro Phe Gly Asp Val Trp Lys Asn Gly Thr Asn Glu Leu Cys Trp Arg 
        35                  40                  45              


Asp Ala Phe Trp Thr Pro Ala Thr Gly Ile Pro Gly Cys Asp Gly Val 
    50                  55                  60                  


Pro Val Ala Gln Lys Glu Lys Ser Ala Pro Met Ala Ala Lys Val Val 
65                  70                  75                  80  


Phe Asn Ala Asp Thr Phe Phe Asp Phe Asp Lys Ser Thr Leu Lys Pro 
                85                  90                  95      


Glu Gly Arg Gln Leu Leu Asp Gln Val Ala Gln Gln Ala Gly Thr Ile 
            100                 105                 110         


Asp Leu Glu Thr Ile Ile Ala Val Gly His Thr Asp Ser Ile Gly Thr 
        115                 120                 125             


Glu Ala Tyr Asn Gln Lys Leu Ser Glu Arg Arg Ala Ala Ala Val Lys 
    130                 135                 140                 


Thr Tyr Leu Val Ser Lys Gly Ile Asp Pro Asn Arg Ile Tyr Thr Glu 
145                 150                 155                 160 


Gly Lys Gly Glu Leu Gln Pro Ile Ala Ser Asn Lys Thr Arg Glu Gly 
                165                 170                 175     


Arg Ala Gln Asn Arg Arg Val Glu Ile Glu Ile Val Gly Ser Arg Lys 
            180                 185                 190         


Asn 
    


<210>  2
<211>  582
<212>  DNA
<213>  Bordetella pertussis

<400>  2
atgaacaaac cctccaaatt cgctctggcg ctcgccttcg ccgctgttac ggcctctggt       60

gcagcttccg cgcaaaccgt ggacaactgg cgcaatccgt ttggcgacgt ttggaagaac      120

ggcaccaatg aactgtgctg gcgcgatgcg ttctggaccc cggctaccgg catccccggt      180

tgcgacggcg ttccggtcgc tcagaaggaa aagtccgctc ccatggccgc caaggtcgtg      240

ttcaatgctg acaccttctt cgacttcgac aagtcgacgc tgaagccgga aggccgccag      300

ctgctggatc aagtcgccca gcaagccggc acgatcgatc tggaaacgat catcgccgtt      360

ggccacacgg actcgatcgg caccgaagcc tacaaccaga agctgtccga gcgccgtgcc      420

gctgcggtca agacctacct ggtcagcaag ggtatcgacc ccaaccgtat ctacacggaa      480

ggcaagggcg aactgcaacc gatcgcttcg aacaagacgc gtgaaggccg tgcccagaac      540

cgtcgcgtgg aaatcgaaat cgtcggtagc cgcaagaact aa                         582


<210>  3
<211>  193
<212>  PRT
<213>  artificial sequence

<220>
<223>  OmpA D124N

<400>  3

Met Asn Lys Pro Ser Lys Phe Ala Leu Ala Leu Ala Phe Ala Ala Val 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ser Ala Gln Thr Val Asp Asn Trp Arg Asn 
            20                  25                  30          


Pro Phe Gly Asp Val Trp Lys Asn Gly Thr Asn Glu Leu Cys Trp Arg 
        35                  40                  45              


Asp Ala Phe Trp Thr Pro Ala Thr Gly Ile Pro Gly Cys Asp Gly Val 
    50                  55                  60                  


Pro Val Ala Gln Lys Glu Lys Ser Ala Pro Met Ala Ala Lys Val Val 
65                  70                  75                  80  


Phe Asn Ala Asp Thr Phe Phe Asp Phe Asp Lys Ser Thr Leu Lys Pro 
                85                  90                  95      


Glu Gly Arg Gln Leu Leu Asp Gln Val Ala Gln Gln Ala Gly Thr Ile 
            100                 105                 110         


Asp Leu Glu Thr Ile Ile Ala Val Gly His Thr Asn Ser Ile Gly Thr 
        115                 120                 125             


Glu Ala Tyr Asn Gln Lys Leu Ser Glu Arg Arg Ala Ala Ala Val Lys 
    130                 135                 140                 


Thr Tyr Leu Val Ser Lys Gly Ile Asp Pro Asn Arg Ile Tyr Thr Glu 
145                 150                 155                 160 


Gly Lys Gly Glu Leu Gln Pro Ile Ala Ser Asn Lys Thr Arg Glu Gly 
                165                 170                 175     


Arg Ala Gln Asn Arg Arg Val Glu Ile Glu Ile Val Gly Ser Arg Lys 
            180                 185                 190         


Asn 
    


<210>  4
<211>  582
<212>  DNA
<213>  artificial sequence

<220>
<223>  OmpA D124N

<400>  4
atgaacaaac cctccaaatt cgctctggcg ctcgccttcg ccgctgttac ggcctctggt       60

gcagcttccg cgcaaaccgt ggacaactgg cgcaatccgt ttggcgacgt ttggaagaac      120

ggcaccaatg aactgtgctg gcgcgatgcg ttctggaccc cggctaccgg catccccggt      180

tgcgacggcg ttccggtcgc tcagaaggaa aagtccgctc ccatggccgc caaggtcgtg      240

ttcaatgctg acaccttctt cgacttcgac aagtcgacgc tgaagccgga aggccgccag      300

ctgctggatc aagtcgccca gcaagccggc acgatcgatc tggaaacgat catcgccgtt      360

ggccacacga actcgatcgg caccgaagcc tacaaccaga agctgtccga gcgccgtgcc      420

gctgcggtca agacctacct ggtcagcaag ggtatcgacc ccaaccgtat ctacacggaa      480

ggcaagggcg aactgcaacc gatcgcttcg aacaagacgc gtgaaggccg tgcccagaac      540

cgtcgcgtgg aaatcgaaat cgtcggtagc cgcaagaact aa                         582


<210>  5
<211>  915
<212>  PRT
<213>  Bordetella pertussis

<400>  5

Met Asn Met Ser Leu Ser Arg Ile Val Lys Ala Ala Pro Leu Arg Arg 
1               5                   10                  15      


Thr Thr Leu Ala Met Ala Leu Gly Ala Leu Gly Ala Ala Pro Ala Ala 
            20                  25                  30          


His Ala Asp Trp Asn Asn Gln Ser Ile Val Lys Thr Gly Glu Arg Gln 
        35                  40                  45              


His Gly Ile His Ile Gln Gly Ser Asp Pro Gly Gly Val Arg Thr Ala 
    50                  55                  60                  


Ser Gly Thr Thr Ile Lys Val Ser Gly Arg Gln Ala Gln Gly Ile Leu 
65                  70                  75                  80  


Leu Glu Asn Pro Ala Ala Glu Leu Gln Phe Arg Asn Gly Ser Val Thr 
                85                  90                  95      


Ser Ser Gly Gln Leu Ser Asp Asp Gly Ile Arg Arg Phe Leu Gly Thr 
            100                 105                 110         


Val Thr Val Lys Ala Gly Lys Leu Val Ala Asp His Ala Thr Leu Ala 
        115                 120                 125             


Asn Val Gly Asp Thr Trp Asp Asp Asp Gly Ile Ala Leu Tyr Val Ala 
    130                 135                 140                 


Gly Glu Gln Ala Gln Ala Ser Ile Ala Asp Ser Thr Leu Gln Gly Ala 
145                 150                 155                 160 


Gly Gly Val Gln Ile Glu Arg Gly Ala Asn Val Thr Val Gln Arg Ser 
                165                 170                 175     


Ala Ile Val Asp Gly Gly Leu His Ile Gly Ala Leu Gln Ser Leu Gln 
            180                 185                 190         


Pro Glu Asp Leu Pro Pro Ser Arg Val Val Leu Arg Asp Thr Asn Val 
        195                 200                 205             


Thr Ala Val Pro Ala Ser Gly Ala Pro Ala Ala Val Ser Val Leu Gly 
    210                 215                 220                 


Ala Ser Glu Leu Thr Leu Asp Gly Gly His Ile Thr Gly Gly Arg Ala 
225                 230                 235                 240 


Ala Gly Val Ala Ala Met Gln Gly Ala Val Val His Leu Gln Arg Ala 
                245                 250                 255     


Thr Ile Arg Arg Gly Asp Ala Pro Ala Gly Gly Ala Val Pro Gly Gly 
            260                 265                 270         


Ala Val Pro Gly Gly Phe Gly Pro Gly Gly Phe Gly Pro Gly Gly Phe 
        275                 280                 285             


Gly Pro Gly Gly Phe Gly Pro Val Leu Asp Gly Trp Tyr Gly Val Asp 
    290                 295                 300                 


Val Ser Gly Ser Ser Val Glu Leu Ala Gln Ser Ile Val Glu Ala Pro 
305                 310                 315                 320 


Glu Leu Gly Ala Ala Ile Arg Val Gly Arg Gly Ala Arg Val Thr Val 
                325                 330                 335     


Ser Gly Gly Ser Leu Ser Ala Pro His Gly Asn Val Ile Glu Thr Gly 
            340                 345                 350         


Gly Ala Arg Arg Phe Ala Pro Gln Ala Ala Pro Leu Ser Ile Thr Leu 
        355                 360                 365             


Gln Ala Gly Ala His Ala Gln Gly Lys Ala Leu Leu Tyr Arg Val Leu 
    370                 375                 380                 


Pro Glu Pro Val Lys Leu Thr Leu Thr Gly Gly Ala Asp Ala Gln Gly 
385                 390                 395                 400 


Asp Ile Val Ala Thr Glu Leu Pro Ser Ile Pro Gly Thr Ser Ile Gly 
                405                 410                 415     


Pro Leu Asp Val Ala Leu Ala Ser Gln Ala Arg Trp Thr Gly Ala Thr 
            420                 425                 430         


Arg Ala Val Asp Ser Leu Ser Ile Asp Asn Ala Thr Trp Val Met Thr 
        435                 440                 445             


Asp Asn Ser Asn Val Gly Ala Leu Arg Leu Ala Ser Asp Gly Ser Val 
    450                 455                 460                 


Asp Phe Gln Gln Pro Ala Glu Ala Gly Arg Phe Lys Val Leu Thr Val 
465                 470                 475                 480 


Asn Thr Leu Ala Gly Ser Gly Leu Phe Arg Met Asn Val Phe Ala Asp 
                485                 490                 495     


Leu Gly Leu Ser Asp Lys Leu Val Val Met Gln Asp Ala Ser Gly Gln 
            500                 505                 510         


His Arg Leu Trp Val Arg Asn Ser Gly Ser Glu Pro Ala Ser Ala Asn 
        515                 520                 525             


Thr Leu Leu Leu Val Gln Thr Pro Leu Gly Ser Ala Ala Thr Phe Thr 
    530                 535                 540                 


Leu Ala Asn Lys Asp Gly Lys Val Asp Ile Gly Thr Tyr Arg Tyr Arg 
545                 550                 555                 560 


Leu Ala Ala Asn Gly Asn Gly Gln Trp Ser Leu Val Gly Ala Lys Ala 
                565                 570                 575     


Pro Pro Ala Pro Lys Pro Ala Pro Gln Pro Gly Pro Gln Pro Pro Gln 
            580                 585                 590         


Pro Pro Gln Pro Gln Pro Glu Ala Pro Ala Pro Gln Pro Pro Ala Gly 
        595                 600                 605             


Arg Glu Leu Ser Ala Ala Ala Asn Ala Ala Val Asn Thr Gly Gly Val 
    610                 615                 620                 


Gly Leu Ala Ser Thr Leu Trp Tyr Ala Glu Ser Asn Ala Leu Ser Lys 
625                 630                 635                 640 


Arg Leu Gly Glu Leu Arg Leu Asn Pro Asp Ala Gly Gly Ala Trp Gly 
                645                 650                 655     


Arg Gly Phe Ala Gln Arg Gln Gln Leu Asp Asn Arg Ala Gly Arg Arg 
            660                 665                 670         


Phe Asp Gln Lys Val Ala Gly Phe Glu Leu Gly Ala Asp His Ala Val 
        675                 680                 685             


Ala Val Ala Gly Gly Arg Trp His Leu Gly Gly Leu Ala Gly Tyr Thr 
    690                 695                 700                 


Arg Gly Asp Arg Gly Phe Thr Gly Asp Gly Gly Gly His Thr Asp Ser 
705                 710                 715                 720 


Val His Val Gly Gly Tyr Ala Thr Tyr Ile Ala Asp Ser Gly Phe Tyr 
                725                 730                 735     


Leu Asp Ala Thr Leu Arg Ala Ser Arg Leu Glu Asn Asp Phe Lys Val 
            740                 745                 750         


Ala Gly Ser Asp Gly Tyr Ala Val Lys Gly Lys Tyr Arg Thr His Gly 
        755                 760                 765             


Val Gly Ala Ser Leu Glu Ala Gly Arg Arg Phe Thr His Ala Asp Gly 
    770                 775                 780                 


Trp Phe Leu Glu Pro Gln Ala Glu Leu Ala Val Phe Arg Ala Gly Gly 
785                 790                 795                 800 


Gly Ala Tyr Arg Ala Ala Asn Gly Leu Arg Val Arg Asp Glu Gly Gly 
                805                 810                 815     


Ser Ser Val Leu Gly Arg Leu Gly Leu Glu Val Gly Lys Arg Ile Glu 
            820                 825                 830         


Leu Ala Gly Gly Arg Gln Val Gln Pro Tyr Ile Lys Ala Ser Val Leu 
        835                 840                 845             


Gln Glu Phe Asp Gly Ala Gly Thr Val His Thr Asn Gly Ile Ala His 
    850                 855                 860                 


Arg Thr Glu Leu Arg Gly Thr Arg Ala Glu Leu Gly Leu Gly Met Ala 
865                 870                 875                 880 


Ala Ala Leu Gly Arg Gly His Ser Leu Tyr Ala Ser Tyr Glu Tyr Ser 
                885                 890                 895     


Lys Gly Pro Lys Leu Ala Met Pro Trp Thr Phe His Ala Gly Tyr Arg 
            900                 905                 910         


Tyr Ser Trp 
        915 


<210>  6
<211>  258
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  6

Met Ser Leu Ile Asp Pro Arg Ala Ile Ile Asp Pro Ser Ala Arg Leu 
1               5                   10                  15      


Ala Ala Asp Val Gln Val Gly Pro Trp Ser Ile Val Gly Ala Glu Val 
            20                  25                  30          


Glu Ile Gly Glu Gly Thr Val Ile Gly Pro His Val Val Leu Lys Gly 
        35                  40                  45              


Pro Thr Lys Ile Gly Lys His Asn Arg Ile Tyr Gln Phe Ser Ser Val 
    50                  55                  60                  


Gly Glu Asp Thr Pro Asp Leu Lys Tyr Lys Gly Glu Pro Thr Arg Leu 
65                  70                  75                  80  


Val Ile Gly Asp His Asn Val Ile Arg Glu Gly Val Thr Ile His Arg 
                85                  90                  95      


Gly Thr Val Gln Asp Arg Ala Glu Thr Thr Ile Gly Asp His Asn Leu 
            100                 105                 110         


Ile Met Ala Tyr Ala His Ile Gly His Asp Ser Val Ile Gly Asn His 
        115                 120                 125             


Cys Ile Leu Val Asn Asn Thr Ala Leu Ala Gly His Val His Val Asp 
    130                 135                 140                 


Asp Trp Ala Ile Leu Ser Gly Tyr Thr Leu Val His Gln Tyr Cys Arg 
145                 150                 155                 160 


Ile Gly Ala His Ser Phe Ser Gly Met Gly Ser Ala Ile Gly Lys Asp 
                165                 170                 175     


Val Pro Ala Tyr Val Thr Val Phe Gly Asn Pro Ala Glu Ala Arg Ser 
            180                 185                 190         


Met Asn Phe Glu Gly Met Arg Arg Arg Gly Phe Ser Ser Glu Ala Ile 
        195                 200                 205             


His Ala Leu Arg Arg Ala Tyr Lys Val Val Tyr Arg Gln Gly His Thr 
    210                 215                 220                 


Val Glu Glu Ala Leu Ala Glu Leu Ala Glu Ser Ala Ala Gln Phe Pro 
225                 230                 235                 240 


Glu Val Ala Val Phe Arg Asp Ser Ile Gln Ser Ala Thr Arg Gly Ile 
                245                 250                 255     


Thr Arg 
        


<210>  7
<211>  353
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  7

Met Met Ser Thr Leu Ser Tyr Thr Leu Gly Gln Leu Ala Ala His Val 
1               5                   10                  15      


Gly Ala Glu Leu Arg Gly Asp Ala Asp Leu Pro Ile Gln Gly Leu Ala 
            20                  25                  30          


Thr Leu Gln Glu Ala Gly Pro Ala Gln Leu Ser Phe Leu Ala Asn Pro 
        35                  40                  45              


Gln Tyr Arg Lys Tyr Leu Pro Glu Ser Arg Ala Gly Ala Val Leu Leu 
    50                  55                  60                  


Thr Ala Ala Asp Ala Asn Gly Phe Ser Gly Thr Ala Leu Val Val Ala 
65                  70                  75                  80  


Asn Pro Tyr Leu Ala Tyr Ala Ser Leu Ser His Leu Phe Asp Arg Lys 
                85                  90                  95      


Pro Lys Ala Ala Ala Gly Ile His Pro Thr Ala Ile Val Ala Ala Asp 
            100                 105                 110         


Ala Glu Val Asp Pro Ser Ala Ser Val Gly Ala Tyr Ala Val Ile Glu 
        115                 120                 125             


Ser Gly Ala Arg Ile Gly Ala Gly Val Ser Ile Gly Ala His Cys Val 
    130                 135                 140                 


Ile Gly Ala Arg Ser Val Ile Gly Glu Gly Gly Trp Leu Ala Pro Arg 
145                 150                 155                 160 


Val Thr Leu Tyr His Asp Val Thr Ile Gly Ala Arg Val Ser Ile Gln 
                165                 170                 175     


Ser Gly Ala Val Ile Gly Gly Glu Gly Phe Gly Phe Ala Asn Glu Lys 
            180                 185                 190         


Gly Val Trp Gln Lys Ile Ala Gln Ile Gly Gly Val Thr Ile Gly Asp 
        195                 200                 205             


Asp Val Glu Ile Gly Ala Asn Thr Thr Ile Asp Arg Gly Ala Leu Ser 
    210                 215                 220                 


Asp Thr Leu Ile Gly Asn Gly Val Lys Leu Asp Asn Gln Ile Met Ile 
225                 230                 235                 240 


Ala His Asn Val Gln Ile Gly Asp His Thr Ala Met Ala Ala Cys Val 
                245                 250                 255     


Gly Ile Ser Gly Ser Ala Lys Ile Gly Arg His Cys Met Leu Ala Gly 
            260                 265                 270         


Gly Val Gly Leu Val Gly His Ile Glu Ile Cys Asp Asn Val Phe Val 
        275                 280                 285             


Thr Gly Met Thr Met Val Thr Arg Ser Ile Thr Glu Pro Gly Ser Tyr 
    290                 295                 300                 


Ser Ser Gly Thr Ala Met Gln Pro Ala Ala Glu Trp Lys Lys Ser Ala 
305                 310                 315                 320 


Ala Arg Ile Arg Gln Leu Asp Asp Met Ala Arg Arg Leu Gln Gln Leu 
                325                 330                 335     


Glu Lys Arg Leu Ala Ala Val Thr Ser Ser Gly Asp Ala Ser Ser Asp 
            340                 345                 350         


Ala 
    


<210>  8
<211>  193
<212>  PRT
<213>  Bordetella parapertussis

<400>  8

Met Asn Lys Pro Ser Lys Phe Ala Leu Ala Leu Ala Phe Ala Ala Val 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ser Ala Gln Thr Val Asp Asn Trp Arg Asn 
            20                  25                  30          


Pro Phe Gly Asp Val Trp Lys Asn Gly Thr Asn Glu Leu Cys Trp Arg 
        35                  40                  45              


Asp Ala Phe Trp Thr Pro Ala Thr Gly Ile Pro Gly Cys Asp Gly Val 
    50                  55                  60                  


Pro Val Ala Gln Lys Glu Lys Pro Ala Pro Met Ala Ala Lys Val Val 
65                  70                  75                  80  


Phe Asn Ala Asp Thr Phe Phe Asp Phe Asp Lys Ser Thr Leu Lys Pro 
                85                  90                  95      


Glu Gly Arg Gln Leu Leu Asp Gln Val Ala Gln Gln Ala Gly Thr Ile 
            100                 105                 110         


Asp Leu Glu Thr Ile Ile Ala Val Gly His Thr Asp Ser Ile Gly Thr 
        115                 120                 125             


Glu Ala Tyr Asn Gln Lys Leu Ser Glu Arg Arg Ala Ala Ala Val Lys 
    130                 135                 140                 


Thr Tyr Leu Val Ser Lys Gly Ile Asp Pro Asn Arg Ile Tyr Thr Glu 
145                 150                 155                 160 


Gly Lys Gly Glu Leu Gln Pro Ile Ala Ser Asn Lys Thr Arg Glu Gly 
                165                 170                 175     


Arg Ala Gln Asn Arg Arg Val Glu Ile Glu Ile Val Gly Ser Arg Lys 
            180                 185                 190         


Asn 
    


<210>  9
<211>  193
<212>  PRT
<213>  Bordetella bronchiseptica

<400>  9

Met Asn Lys Pro Ser Lys Phe Ala Leu Ala Leu Ala Phe Ala Ala Val 
1               5                   10                  15      


Thr Ala Ser Gly Ala Ala Ser Ala Gln Thr Val Asp Asn Trp Arg Asn 
            20                  25                  30          


Pro Phe Gly Asp Val Trp Lys Asn Gly Thr Asn Glu Leu Cys Trp Arg 
        35                  40                  45              


Asp Ala Phe Trp Thr Pro Ala Thr Gly Ile Pro Gly Cys Asp Gly Val 
    50                  55                  60                  


Pro Val Ala Gln Lys Glu Lys Pro Ala Pro Met Ala Ala Lys Val Val 
65                  70                  75                  80  


Phe Asn Ala Asp Thr Phe Phe Asp Phe Asp Lys Ser Thr Leu Lys Pro 
                85                  90                  95      


Glu Gly Arg Gln Leu Leu Asp Gln Val Ala Gln Gln Ala Gly Thr Ile 
            100                 105                 110         


Asp Leu Glu Thr Ile Ile Ala Val Gly His Thr Asp Ser Ile Gly Thr 
        115                 120                 125             


Glu Ala Tyr Asn Gln Lys Leu Ser Glu Arg Arg Ala Ala Ala Val Lys 
    130                 135                 140                 


Thr Tyr Leu Val Ser Lys Gly Ile Asp Pro Asn Arg Ile Tyr Thr Glu 
145                 150                 155                 160 


Gly Lys Gly Glu Leu Gln Pro Ile Ala Ser Asn Lys Thr Arg Glu Gly 
                165                 170                 175     


Arg Ala Gln Asn Arg Arg Val Glu Ile Glu Ile Val Gly Ser Arg Lys 
            180                 185                 190         


Asn 
    


<210>  10
<211>  1464
<212>  PRT
<213>  Bordetella pertussis

<400>  10

Met Asp Lys Asp Glu Ser Ala Leu Arg Gln Leu Val Asp Met Ala Leu 
1               5                   10                  15      


Val Gly Tyr Asp Gly Val Val Glu Glu Leu Leu Ala Leu Pro Ser Glu 
            20                  25                  30          


Glu Ser Gly Asp Leu Ala Gly Gly Arg Ala Lys Arg Glu Lys Ala Glu 
        35                  40                  45              


Phe Ala Leu Phe Ser Glu Ala Pro Asn Gly Asp Glu Pro Ile Gly Gln 
    50                  55                  60                  


Asp Ala Arg Thr Trp Phe Tyr Phe Pro Lys Tyr Arg Pro Val Ala Val 
65                  70                  75                  80  


Ser Asn Leu Lys Lys Met Gln Val Ala Ile Arg Ala Arg Leu Glu Pro 
                85                  90                  95      


Glu Ser Leu Ile Leu Gln Trp Leu Ile Ala Leu Asp Val Tyr Leu Gly 
            100                 105                 110         


Val Leu Ile Ala Ala Leu Ser Arg Thr Val Ile Ser Asp Leu Val Phe 
        115                 120                 125             


Glu Tyr Val Lys Ala Arg Tyr Glu Ile Tyr Tyr Leu Leu Asn Arg Val 
    130                 135                 140                 


Pro His Pro Leu Ala Thr Ala Tyr Leu Lys Arg Arg Arg Gln Arg Pro 
145                 150                 155                 160 


Val Asp Arg Ser Gly Arg Leu Gly Ser Val Phe Glu His Pro Leu Trp 
                165                 170                 175     


Phe Ala Tyr Asp Glu Leu Ala Gly Thr Val Asp Leu Asp Ala Asp Ile 
            180                 185                 190         


Tyr Glu Gln Ala Leu Ala Glu Ser Ile Glu Arg Arg Met Asp Gly Glu 
        195                 200                 205             


Pro Asp Asp Gly Ser Leu Asp Thr Ala Glu His Asp Val Trp Arg Leu 
    210                 215                 220                 


Cys Arg Asp Gly Ile Asn Arg Gly Glu Gln Ala Ile Phe Gln Ala Ser 
225                 230                 235                 240 


Gly Pro Tyr Gly Val Val Ala Asp Ala Gly Tyr Met Arg Thr Val Ala 
                245                 250                 255     


Asp Leu Ala Tyr Ala Asp Ala Leu Ala Asp Cys Leu His Ala Gln Leu 
            260                 265                 270         


Arg Ile Arg Ala Gln Gly Ser Val Asp Ser Pro Gly Asp Glu Met Pro 
        275                 280                 285             


Arg Lys Leu Asp Ala Trp Glu Ile Ala Lys Phe His Leu Ala Ala Thr 
    290                 295                 300                 


Gln Gln Ala Arg Val Asp Leu Leu Glu Ala Ala Phe Ala Leu Asp Tyr 
305                 310                 315                 320 


Ala Ala Leu Arg Asp Val Arg Val Tyr Gly Asp Tyr Arg Asn Ala Leu 
                325                 330                 335     


Ala Leu Arg Phe Ile Lys Arg Glu Ala Leu Arg Leu Leu Gly Ala Arg 
            340                 345                 350         


Arg Gly Asn Ala Ser Thr Met Pro Ala Val Ala Ala Gly Glu Tyr Asp 
        355                 360                 365             


Glu Ile Val Ala Ser Gly Ala Ala Asn Asp Ala Ala Tyr Val Ser Met 
    370                 375                 380                 


Ala Ala Ala Leu Ile Ala Gly Val Leu Cys Asp Leu Glu Ser Ala Gln 
385                 390                 395                 400 


Arg Thr Leu Pro Val Val Leu Ala Arg Phe Arg Pro Leu Gly Val Leu 
                405                 410                 415     


Ala Arg Phe Arg Arg Leu Glu Gln Glu Thr Ala Gly Met Leu Leu Gly 
            420                 425                 430         


Asp Gln Glu Pro Glu Pro Arg Gly Phe Ile Ser Phe Thr Asp Phe Arg 
        435                 440                 445             


Asp Ser Asp Ala Phe Ala Ser Tyr Ala Glu Tyr Ala Ala Gln Phe Asn 
    450                 455                 460                 


Asp Tyr Ile Asp Gln Tyr Ser Ile Leu Glu Ala Gln Arg Leu Ala Arg 
465                 470                 475                 480 


Ile Leu Ala Leu Gly Ser Arg Met Thr Val Asp Gln Trp Cys Leu Pro 
                485                 490                 495     


Leu Gln Lys Val Arg His Tyr Lys Val Leu Thr Ser Gln Pro Gly Leu 
            500                 505                 510         


Ile Ala Arg Gly Ile Glu Asn His Asn Arg Gly Ile Glu Tyr Cys Leu 
        515                 520                 525             


Gly Arg Pro Pro Leu Thr Asp Leu Pro Gly Leu Phe Thr Met Phe Gln 
    530                 535                 540                 


Leu His Asp Ser Ser Trp Leu Leu Val Ser Asn Ile Asn Gly Glu Leu 
545                 550                 555                 560 


Trp Ser Asp Val Leu Ala Asn Ala Glu Val Met Gln Asn Pro Thr Leu 
                565                 570                 575     


Ala Ala Leu Ala Glu Pro Gln Gly Arg Phe Arg Thr Gly Arg Arg Thr 
            580                 585                 590         


Gly Gly Trp Phe Leu Gly Gly Pro Ala Thr Glu Gly Pro Ser Leu Arg 
        595                 600                 605             


Asp Asn Tyr Leu Leu Lys Leu Arg Gln Ser Asn Pro Gly Leu Asp Val 
    610                 615                 620                 


Lys Lys Cys Trp Tyr Phe Gly Tyr Arg Gln Glu Tyr Arg Leu Pro Ala 
625                 630                 635                 640 


Gly Ala Leu Gly Val Pro Leu Phe Ala Val Ser Val Ala Leu Arg His 
                645                 650                 655     


Ser Leu Asp Asp Leu Ala Ala His Ala Lys Ser Ala Leu Tyr Lys Pro 
            660                 665                 670         


Ser Glu Trp Gln Lys Phe Ala Phe Trp Ile Val Pro Phe Tyr Arg Glu 
        675                 680                 685             


Ile Phe Phe Ser Thr Gln Asp Arg Ser Tyr Arg Val Asp Val Gly Ser 
    690                 695                 700                 


Ile Val Phe Asp Ser Ile Ser Leu Leu Ala Ser Val Phe Ser Ile Gly 
705                 710                 715                 720 


Gly Lys Leu Gly Ser Phe Thr Arg Thr Gln Tyr Gly Asn Leu Arg Asn 
                725                 730                 735     


Phe Val Val Arg Gln Arg Ile Ala Gly Leu Ser Gly Gln Arg Leu Trp 
            740                 745                 750         


Arg Ser Val Leu Lys Glu Leu Pro Ala Leu Ile Gly Ala Ser Gly Leu 
        755                 760                 765             


Arg Leu Ser Arg Ser Leu Leu Val Asp Leu Tyr Glu Ile Phe Glu Pro 
    770                 775                 780                 


Val Pro Ile Arg Arg Leu Val Ala Gly Phe Val Ser Ala Thr Thr Val 
785                 790                 795                 800 


Gly Gly Arg Asn Gln Ala Phe Leu Arg Gln Ala Phe Ser Ala Ala Ser 
                805                 810                 815     


Ser Ser Ala Gly Arg Thr Gly Gly Gln Leu Ala Ser Glu Trp Arg Met 
            820                 825                 830         


Ala Gly Val Asp Ala Thr Gly Leu Val Glu Ser Thr Ser Gly Gly Arg 
        835                 840                 845             


Phe Glu Gly Ile Tyr Thr Arg Gly Leu Gly Pro Leu Ser Glu Cys Thr 
    850                 855                 860                 


Glu His Phe Ile Val Glu Ser Gly Asn Ala Tyr Arg Val Ile Trp Asp 
865                 870                 875                 880 


Ala Tyr Thr His Gly Trp Arg Val Val Asn Gly Arg Leu Pro Pro Arg 
                885                 890                 895     


Leu Thr Tyr Thr Val Pro Val Arg Leu Asn Gly Gln Gly His Trp Glu 
            900                 905                 910         


Thr His Leu Asp Val Pro Gly Arg Gly Gly Ala Pro Glu Ile Phe Gly 
        915                 920                 925             


Arg Ile Arg Thr Arg Asn Leu Val Ala Leu Ala Ala Glu Gln Ala Ala 
    930                 935                 940                 


Pro Met Arg Arg Leu Leu Asn Gln Ala Arg Arg Val Ala Leu Arg His 
945                 950                 955                 960 


Ile Asp Thr Cys Arg Ser Arg Leu Ala Leu Pro Arg Ala Glu Ser Asp 
                965                 970                 975     


Met Asp Ala Ala Ile Arg Ile Phe Phe Gly Glu Pro Asp Ala Gly Leu 
            980                 985                 990         


Arg Gln Arg Ile Gly Arg Arg Leu  Gln Glu Val Arg Ala  Tyr Ile Gly 
        995                 1000                 1005             


Asp Leu  Ser Pro Val Asn Asp  Val Leu Tyr Arg Ala  Gly Tyr Asp 
    1010                 1015                 1020             


Leu Asp  Asp Val Ala Thr Leu  Phe Asn Ala Val Asp  Arg Asn Thr 
    1025                 1030                 1035             


Ser Leu  Gly Arg Gln Ala Arg  Met Glu Leu Tyr Leu  Asp Ala Ile 
    1040                 1045                 1050             


Val Asp  Leu His Ala Arg Leu  Gly Tyr Glu Asn Ala  Arg Phe Val 
    1055                 1060                 1065             


Asp Leu  Met Ala Phe His Leu  Leu Ser Leu Gly His  Ala Ala Thr 
    1070                 1075                 1080             


Ala Ser  Glu Val Val Glu Ala  Val Ser Pro Arg Leu  Leu Gly Asn 
    1085                 1090                 1095             


Val Phe  Asp Ile Ser Asn Val  Ala Gln Leu Glu Arg  Gly Ile Gly 
    1100                 1105                 1110             


Asn Pro  Ala Ser Thr Gly Leu  Phe Val Met Leu Gly  Ala Tyr Ser 
    1115                 1120                 1125             


Glu Ser  Ser Pro Ala Ile Phe  Gln Ser Phe Val Asn  Asp Ile Phe 
    1130                 1135                 1140             


Pro Ala  Trp Arg Gln Ala Ser  Gly Gly Gly Pro Leu  Val Trp Asn 
    1145                 1150                 1155             


Phe Gly  Pro Ala Ala Ile Ser  Pro Thr Arg Leu Asp  Tyr Ala Asn 
    1160                 1165                 1170             


Thr Asp  Ile Gly Leu Leu Asn  His Gly Asp Ile Ser  Pro Leu Arg 
    1175                 1180                 1185             


Ala Arg  Pro Pro Leu Gly Gly  Arg Arg Asp Ile Asp  Leu Pro Pro 
    1190                 1195                 1200             


Gly Leu  Asp Ile Ser Phe Val  Arg Tyr Asp Arg Pro  Val Arg Met 
    1205                 1210                 1215             


Ser Ala  Pro Arg Ala Leu Asp  Ala Ser Val Phe Arg  Pro Val Asp 
    1220                 1225                 1230             


Gly Pro  Val His Gly Tyr Ile  Gln Ser Trp Thr Gly  Ala Glu Ile 
    1235                 1240                 1245             


Glu Tyr  Ala Tyr Gly Ala Pro  Ala Ala Ala Arg Glu  Val Met Leu 
    1250                 1255                 1260             


Thr Asp  Asn Val Arg Ile Ile  Ser Ile Glu Asn Gly  Asp Glu Gly 
    1265                 1270                 1275             


Ala Ile  Gly Val Arg Val Arg  Leu Asp Thr Val Pro  Val Ala Thr 
    1280                 1285                 1290             


Pro Leu  Ile Leu Thr Gly Gly  Ser Leu Ser Gly Cys  Thr Thr Met 
    1295                 1300                 1305             


Val Gly  Val Lys Glu Gly Tyr  Leu Ala Phe Tyr His  Thr Gly Lys 
    1310                 1315                 1320             


Ser Thr  Glu Leu Gly Asp Trp  Ala Thr Ala Arg Glu  Gly Val Gln 
    1325                 1330                 1335             


Ala Leu  Tyr Gln Ala His Leu  Ala Met Gly Tyr Ala  Pro Ile Ser 
    1340                 1345                 1350             


Ile Pro  Ala Pro Met Arg Asn  Asp Asp Leu Val Ser  Ile Ala Ala 
    1355                 1360                 1365             


Thr Tyr  Asp Arg Ala Val Ile  Ala Tyr Leu Gly Lys  Asp Val Pro 
    1370                 1375                 1380             


Gly Gly  Gly Ser Thr Arg Ile  Thr Arg His Asp Glu  Gly Ala Gly 
    1385                 1390                 1395             


Ser Val  Val Ser Phe Asp Tyr  Asn Ala Ala Val Gln  Ala Ser Ala 
    1400                 1405                 1410             


Val Pro  Arg Leu Gly Gln Val  Tyr Val Leu Ile Ser  Asn Asp Gly 
    1415                 1420                 1425             


Gln Gly  Ala Arg Ala Val Leu  Leu Ala Glu Asp Leu  Ala Trp Ala 
    1430                 1435                 1440             


Gly Ser  Gly Ser Ala Leu Asp  Val Leu Asn Glu Arg  Leu Val Thr 
    1445                 1450                 1455             


Leu Phe  Pro Ala Pro Val 
    1460                 


<210>  11
<211>  915
<212>  PRT
<213>  artificial sequence

<220>
<223>  Pertactin D738N mutation

<400>  11

Met Asn Met Ser Leu Ser Arg Ile Val Lys Ala Ala Pro Leu Arg Arg 
1               5                   10                  15      


Thr Thr Leu Ala Met Ala Leu Gly Ala Leu Gly Ala Ala Pro Ala Ala 
            20                  25                  30          


His Ala Asp Trp Asn Asn Gln Ser Ile Val Lys Thr Gly Glu Arg Gln 
        35                  40                  45              


His Gly Ile His Ile Gln Gly Ser Asp Pro Gly Gly Val Arg Thr Ala 
    50                  55                  60                  


Ser Gly Thr Thr Ile Lys Val Ser Gly Arg Gln Ala Gln Gly Ile Leu 
65                  70                  75                  80  


Leu Glu Asn Pro Ala Ala Glu Leu Gln Phe Arg Asn Gly Ser Val Thr 
                85                  90                  95      


Ser Ser Gly Gln Leu Ser Asp Asp Gly Ile Arg Arg Phe Leu Gly Thr 
            100                 105                 110         


Val Thr Val Lys Ala Gly Lys Leu Val Ala Asp His Ala Thr Leu Ala 
        115                 120                 125             


Asn Val Gly Asp Thr Trp Asp Asp Asp Gly Ile Ala Leu Tyr Val Ala 
    130                 135                 140                 


Gly Glu Gln Ala Gln Ala Ser Ile Ala Asp Ser Thr Leu Gln Gly Ala 
145                 150                 155                 160 


Gly Gly Val Gln Ile Glu Arg Gly Ala Asn Val Thr Val Gln Arg Ser 
                165                 170                 175     


Ala Ile Val Asp Gly Gly Leu His Ile Gly Ala Leu Gln Ser Leu Gln 
            180                 185                 190         


Pro Glu Asp Leu Pro Pro Ser Arg Val Val Leu Arg Asp Thr Asn Val 
        195                 200                 205             


Thr Ala Val Pro Ala Ser Gly Ala Pro Ala Ala Val Ser Val Leu Gly 
    210                 215                 220                 


Ala Ser Glu Leu Thr Leu Asp Gly Gly His Ile Thr Gly Gly Arg Ala 
225                 230                 235                 240 


Ala Gly Val Ala Ala Met Gln Gly Ala Val Val His Leu Gln Arg Ala 
                245                 250                 255     


Thr Ile Arg Arg Gly Asp Ala Pro Ala Gly Gly Ala Val Pro Gly Gly 
            260                 265                 270         


Ala Val Pro Gly Gly Phe Gly Pro Gly Gly Phe Gly Pro Gly Gly Phe 
        275                 280                 285             


Gly Pro Gly Gly Phe Gly Pro Val Leu Asp Gly Trp Tyr Gly Val Asp 
    290                 295                 300                 


Val Ser Gly Ser Ser Val Glu Leu Ala Gln Ser Ile Val Glu Ala Pro 
305                 310                 315                 320 


Glu Leu Gly Ala Ala Ile Arg Val Gly Arg Gly Ala Arg Val Thr Val 
                325                 330                 335     


Ser Gly Gly Ser Leu Ser Ala Pro His Gly Asn Val Ile Glu Thr Gly 
            340                 345                 350         


Gly Ala Arg Arg Phe Ala Pro Gln Ala Ala Pro Leu Ser Ile Thr Leu 
        355                 360                 365             


Gln Ala Gly Ala His Ala Gln Gly Lys Ala Leu Leu Tyr Arg Val Leu 
    370                 375                 380                 


Pro Glu Pro Val Lys Leu Thr Leu Thr Gly Gly Ala Asp Ala Gln Gly 
385                 390                 395                 400 


Asp Ile Val Ala Thr Glu Leu Pro Ser Ile Pro Gly Thr Ser Ile Gly 
                405                 410                 415     


Pro Leu Asp Val Ala Leu Ala Ser Gln Ala Arg Trp Thr Gly Ala Thr 
            420                 425                 430         


Arg Ala Val Asp Ser Leu Ser Ile Asp Asn Ala Thr Trp Val Met Thr 
        435                 440                 445             


Asp Asn Ser Asn Val Gly Ala Leu Arg Leu Ala Ser Asp Gly Ser Val 
    450                 455                 460                 


Asp Phe Gln Gln Pro Ala Glu Ala Gly Arg Phe Lys Val Leu Thr Val 
465                 470                 475                 480 


Asn Thr Leu Ala Gly Ser Gly Leu Phe Arg Met Asn Val Phe Ala Asp 
                485                 490                 495     


Leu Gly Leu Ser Asp Lys Leu Val Val Met Gln Asp Ala Ser Gly Gln 
            500                 505                 510         


His Arg Leu Trp Val Arg Asn Ser Gly Ser Glu Pro Ala Ser Ala Asn 
        515                 520                 525             


Thr Leu Leu Leu Val Gln Thr Pro Leu Gly Ser Ala Ala Thr Phe Thr 
    530                 535                 540                 


Leu Ala Asn Lys Asp Gly Lys Val Asp Ile Gly Thr Tyr Arg Tyr Arg 
545                 550                 555                 560 


Leu Ala Ala Asn Gly Asn Gly Gln Trp Ser Leu Val Gly Ala Lys Ala 
                565                 570                 575     


Pro Pro Ala Pro Lys Pro Ala Pro Gln Pro Gly Pro Gln Pro Pro Gln 
            580                 585                 590         


Pro Pro Gln Pro Gln Pro Glu Ala Pro Ala Pro Gln Pro Pro Ala Gly 
        595                 600                 605             


Arg Glu Leu Ser Ala Ala Ala Asn Ala Ala Val Asn Thr Gly Gly Val 
    610                 615                 620                 


Gly Leu Ala Ser Thr Leu Trp Tyr Ala Glu Ser Asn Ala Leu Ser Lys 
625                 630                 635                 640 


Arg Leu Gly Glu Leu Arg Leu Asn Pro Asp Ala Gly Gly Ala Trp Gly 
                645                 650                 655     


Arg Gly Phe Ala Gln Arg Gln Gln Leu Asp Asn Arg Ala Gly Arg Arg 
            660                 665                 670         


Phe Asp Gln Lys Val Ala Gly Phe Glu Leu Gly Ala Asp His Ala Val 
        675                 680                 685             


Ala Val Ala Gly Gly Arg Trp His Leu Gly Gly Leu Ala Gly Tyr Thr 
    690                 695                 700                 


Arg Gly Asp Arg Gly Phe Thr Gly Asp Gly Gly Gly His Thr Asp Ser 
705                 710                 715                 720 


Val His Val Gly Gly Tyr Ala Thr Tyr Ile Ala Asp Ser Gly Phe Tyr 
                725                 730                 735     


Leu Asn Ala Thr Leu Arg Ala Ser Arg Leu Glu Asn Asp Phe Lys Val 
            740                 745                 750         


Ala Gly Ser Asp Gly Tyr Ala Val Lys Gly Lys Tyr Arg Thr His Gly 
        755                 760                 765             


Val Gly Ala Ser Leu Glu Ala Gly Arg Arg Phe Thr His Ala Asp Gly 
    770                 775                 780                 


Trp Phe Leu Glu Pro Gln Ala Glu Leu Ala Val Phe Arg Ala Gly Gly 
785                 790                 795                 800 


Gly Ala Tyr Arg Ala Ala Asn Gly Leu Arg Val Arg Asp Glu Gly Gly 
                805                 810                 815     


Ser Ser Val Leu Gly Arg Leu Gly Leu Glu Val Gly Lys Arg Ile Glu 
            820                 825                 830         


Leu Ala Gly Gly Arg Gln Val Gln Pro Tyr Ile Lys Ala Ser Val Leu 
        835                 840                 845             


Gln Glu Phe Asp Gly Ala Gly Thr Val His Thr Asn Gly Ile Ala His 
    850                 855                 860                 


Arg Thr Glu Leu Arg Gly Thr Arg Ala Glu Leu Gly Leu Gly Met Ala 
865                 870                 875                 880 


Ala Ala Leu Gly Arg Gly His Ser Leu Tyr Ala Ser Tyr Glu Tyr Ser 
                885                 890                 895     


Lys Gly Pro Lys Leu Ala Met Pro Trp Thr Phe His Ala Gly Tyr Arg 
            900                 905                 910         


Tyr Ser Trp 
        915 


<210>  12
<211>  269
<212>  PRT
<213>  Bordetella pertussis

<400>  12

Met Arg Cys Thr Arg Ala Ile Arg Gln Thr Ala Arg Thr Gly Trp Leu 
1               5                   10                  15      


Thr Trp Leu Ala Ile Leu Ala Val Thr Ala Pro Val Thr Ser Pro Ala 
            20                  25                  30          


Trp Ala Asp Asp Pro Pro Ala Thr Val Tyr Arg Tyr Asp Ser Arg Pro 
        35                  40                  45              


Pro Glu Asp Val Phe Gln Asn Gly Phe Thr Ala Trp Gly Asn Asn Asp 
    50                  55                  60                  


Asn Val Leu Asp His Leu Thr Gly Arg Ser Cys Gln Val Gly Ser Ser 
65                  70                  75                  80  


Asn Ser Ala Phe Val Ser Thr Ser Ser Ser Arg Arg Tyr Thr Glu Val 
                85                  90                  95      


Tyr Leu Glu His Arg Met Gln Glu Ala Val Glu Ala Glu Arg Ala Gly 
            100                 105                 110         


Arg Gly Thr Gly His Phe Ile Gly Tyr Ile Tyr Glu Val Arg Ala Asp 
        115                 120                 125             


Asn Asn Phe Tyr Gly Ala Ala Ser Ser Tyr Phe Glu Tyr Val Asp Thr 
    130                 135                 140                 


Tyr Gly Asp Asn Ala Gly Arg Ile Leu Ala Gly Ala Leu Ala Thr Tyr 
145                 150                 155                 160 


Gln Ser Glu Tyr Leu Ala His Arg Arg Ile Pro Pro Glu Asn Ile Arg 
                165                 170                 175     


Arg Val Thr Arg Val Tyr His Asn Gly Ile Thr Gly Glu Thr Thr Thr 
            180                 185                 190         


Thr Glu Tyr Ser Asn Ala Arg Tyr Val Ser Gln Gln Thr Arg Ala Asn 
        195                 200                 205             


Pro Asn Pro Tyr Thr Ser Arg Arg Ser Val Ala Ser Ile Val Gly Thr 
    210                 215                 220                 


Leu Val Arg Met Ala Pro Val Ile Gly Ala Cys Met Ala Arg Gln Ala 
225                 230                 235                 240 


Glu Ser Ser Glu Ala Met Ala Ala Trp Ser Glu Arg Ala Gly Glu Ala 
                245                 250                 255     


Met Val Leu Val Tyr Tyr Glu Ser Ile Ala Tyr Ser Phe 
            260                 265                 


<210>  13
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer B1917-OmpA-Fw

<400>  13
ggtcaatgca acggtctagg                                                   20


<210>  14
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer OmpA-D124N-Rv

<400>  14
gccgatcgag ttcgtgtggc caac                                              24


<210>  15
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer OmpA-D124N-Fw

<400>  15
ttggccacac gaactcgatc gg                                                22


<210>  16
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer B1917-OmpA-Rv

<400>  16
atgctctccg acaggatg                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer OmpA-seq-Fw

<400>  17
cgtatgtaag gatgaacc                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer OmpA-seq-Rv2

<400>  18
tgttcgagca tttccatg                                                     18


